Roles > protein denaturant
Page last updated: 2024-08-05 15:27:06

protein denaturant

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ChEBI ID: 50533

Members (2)

MemberDefinitionClass
guanidine hydrochlorideguanidinium chloride
sodium dodecyl sulfateAn organic sodium salt that is the sodium salt of dodecyl hydrogen sulfate.sodium dodecyl sulfate

Research

Studies (12,512)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-19905,189 (41.47)18.7374
1990's2,118 (16.93)18.2507
2000's2,468 (19.73)29.6817
2010's2,267 (18.12)24.3611
2020's470 (3.76)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials257 (1.98%)5.53%
Reviews136 (1.05%)6.00%
Case Studies47 (0.36%)4.05%
Observational2 (0.02%)0.25%
Other12,509 (96.59%)84.16%

Protein Targets (41)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1Homo sapiens (human)Potency11.220211
alpha-galactosidaseHomo sapiens (human)Potency39.810711
AR proteinHomo sapiens (human)Potency27.306011
Cellular tumor antigen p53Homo sapiens (human)Potency44.042224
Chain A, ATP-DEPENDENT DNA HELICASE Q1Homo sapiens (human)Potency39.810711
Chain A, CruzipainTrypanosoma cruziPotency28.370812
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency0.012211
estrogen nuclear receptor alphaHomo sapiens (human)Potency30.720234
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency40.312822
farnesoid X nuclear receptorHomo sapiens (human)Potency27.079422
gemininHomo sapiens (human)Potency9.441111
GLI family zinc finger 3Homo sapiens (human)Potency41.778612
histone acetyltransferase KAT2A isoform 1Homo sapiens (human)Potency35.481311
hypoxia-inducible factor 1 alpha subunitHomo sapiens (human)Potency24.230512
interleukin 8Homo sapiens (human)Potency74.978011
lamin isoform A-delta10Homo sapiens (human)Potency0.000911
lethal factor (plasmid)Bacillus anthracis str. A2012Potency0.100011
LuciferasePhotinus pyralis (common eastern firefly)Potency69.891923
mitogen-activated protein kinase 1Homo sapiens (human)Potency39.810711
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency72.404935
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency54.955412
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency39.810711
Peroxisome proliferator-activated receptor alphaHomo sapiens (human)Potency44.668411
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency53.082224
pregnane X nuclear receptorHomo sapiens (human)Potency60.261311
RAR-related orphan receptor gammaMus musculus (house mouse)Potency14.960111
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency26.917711
retinoid X nuclear receptor alphaHomo sapiens (human)Potency61.644811
SMAD family member 2Homo sapiens (human)Potency24.190411
SMAD family member 3Homo sapiens (human)Potency24.190411
Spike glycoproteinSevere acute respiratory syndrome-related coronavirusPotency6.309611
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency34.531624
thyroid hormone receptor beta isoform aHomo sapiens (human)Potency28.120212
thyroid stimulating hormone receptorHomo sapiens (human)Potency53.712544
USP1 protein, partialHomo sapiens (human)Potency79.432811
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency54.941022
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency22.495833
vitamin D3 receptor isoform VDRAHomo sapiens (human)Potency44.668411

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Bifunctional epoxide hydrolase 2Homo sapiens (human)IC50135.500033

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
L-lactate dehydrogenase B chainHomo sapiens (human)EC50843,142.857177