| Member | Definition | Role |
|---|
| 1-(2-Naphthylmethyl)-2,3-dioxo-indoline-5-carboxamide | | 1-(2-Naphthylmethyl)-2,3-dioxo-indoline-5-carboxamide |
| 1-[(1R)-1-(1-ethylsulfonyl-4-piperidinyl)ethyl]-N-[(4-methoxy-6-methyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methyl-3-indolecarboxamide | | 1-[(1R)-1-(1-ethylsulfonyl-4-piperidinyl)ethyl]-N-[(4-methoxy-6-methyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methyl-3-indolecarboxamide |
| 1-[1-naphthalenyl(oxo)methyl]-3-indolecarboxylic acid methyl ester | | 1-[1-naphthalenyl(oxo)methyl]-3-indolecarboxylic acid methyl ester |
| 1-[2-(dimethylamino)ethyl]-5-methoxy-N-methyl-2-indolecarboxamide | | 1-[2-(dimethylamino)ethyl]-5-methoxy-N-methyl-2-indolecarboxamide |
| 3-amino-4-methoxy-1H-indole-2-carbohydrazide | | 3-amino-4-methoxy-1H-indole-2-carbohydrazide |
| 3-fluoro-Nalpha-(1H-indol-2-ylcarbonyl)-N-{(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-phenylalaninamide | A secondary carboxamide resulting from the formal condensation of the carboxy group of 1H-indole-2-carboxylic acid with the primary amino group of 3-fluoro-N-{(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-phenylalaninamide. It is an inhibitor of SARS coronavirus main proteinase and inhibits SARS-CoV-2 replication in cell culture (EC50 = 0.72 muM). | 3-fluoro-Nalpha-(1H-indol-2-ylcarbonyl)-N-{(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-phenylalaninamide |
| 5-methoxy-N-(1-methoxypropan-2-yl)-1H-indole-2-carboxamide | | 5-methoxy-N-(1-methoxypropan-2-yl)-1H-indole-2-carboxamide |
| AM2201 | | AM2201 |
| delavirdine | The amide resulting from the formal condensation of 5-[(methylsulfonyl)amino]-1H-indole-2-carboxylic acid and 4-amino group of 1-[3-(isopropylamino)pyridin-2-yl]piperazine, delavirdine is a non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1. Viral resistance emerges rapidly when delavirdine is used alone, so it is therefore used (as the methanesulfonic acid salt) with other antiretrovirals for combination therapy of HIV infection. | delavirdine |
| devazepide | An indolecarboxamide obtained by formal condensation of the carboxy group of indole-2-carboxylic acid with the exocyclic amino group of (3S)-3-amino-1-methyl-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one. A cholecystokinin antagonist used for treatment of gastrointestinal disorders. | devazepide |
| jaw | | 1H-indole-5-carboxamide |
| jhw 015 | | (2-methyl-1-propyl-3-indolyl)-(1-naphthalenyl)methanone |
| jwh 018 | | JWH 018 |
| jwh-073 | | 1-Butyl-3-(1-naphthoyl)indole |
| jwh-210 | | JWH182 |
| N-[(2S)-3-cyclohexyl-1-oxo-1-({(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}amino)propan-2-yl]-1H-indole-2-carboxamide | A secondary carboxamide resulting from the formal condensation of the carboxy group of 1H-indole-2-carboxylic acid with the primary amino group of 3-cyclohexyl-N-{(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-alaninamide. It is an inhibitor of SARS coronavirus main proteinase and inhibits SARS-CoV-2 replication in cell culture (EC50 = 0.53 muM). | N-[(2S)-3-cyclohexyl-1-oxo-1-({(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}amino)propan-2-yl]-1H-indole-2-carboxamide |
| N-[[1H-indol-2-yl(oxo)methyl]amino]carbamic acid (phenylmethyl) ester | | N-[[1H-indol-2-yl(oxo)methyl]amino]carbamic acid (phenylmethyl) ester |
| N-butyl-5-methoxy-1H-indole-2-carboxamide | | N-butyl-5-methoxy-1H-indole-2-carboxamide |
| n,n-dipropylcarboxamidotryptamine | | 3-[2-(dipropylamino)ethyl]-1H-indole-5-carboxamide |
| N'-[(2-chlorophenyl)-oxomethyl]-5-(trifluoromethoxy)-1H-indole-2-carbohydrazide | | N'-[(2-chlorophenyl)-oxomethyl]-5-(trifluoromethoxy)-1H-indole-2-carbohydrazide |
| nsc 716970 | An indolecarboxamide obtained by the formal condensation of the carboxy group of 5,6,7-trimethoxyindole-2-carboxylic acid with the 2-amino group of 1-(2-chloroethyl)-2,4-diaminonaphthalene. | AS-I-145 |
| pci 34051 | | N-hydroxy-1-[(4-methoxyphenyl)methyl]-6-indolecarboxamide |
| PF-00835231 | A primary alcohol resulting from the cleavage of the phosphate group of the prodrug PF-07304814. It is an inhibitor of SARS-CoV-1 and -2 main protease (3CLpro) and exhibits potent in vitro antiviral activity. | PF-00835231 |
| PF-07304814 | An indolecarboxamide resulting from the formal condensation of the carboxy group of 4-methoxy-1H-indole-2-carboxylic acid with the primary amino group of N-[(2S)-3-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]-4-(phosphonooxy)butan-2-yl]-L-leucinamide. It is the phosphate prodrug of PF-00835231, an anticoronaviral agent. | PF-07304814 |
| scio-469 | An indolecarboxamide obtained by formal condensation of the carboxy group of 6-chloro-3-[(dimethylamino)(oxo)acetyl]-1-methylindole-5-carboxylic acid with the secondary amino group of (2S,5R)-1-[(4-fluorophenyl)methyl]-2,5-dimethylpiperazine. It is a potent inhibitor of MAPK and exhibits anti-cancer properties. | talmapimod |
| silodosin | | silodosin |
| sr1664 | | [1,1'-biphenyl]-2-carboxylic acid, 4'-[[2,3-dimethyl-5-[[[(1s)-1-(4-nitrophenyl)ethyl]amino]carbonyl]-1h-indol-1-yl]methyl]- |
| sts-135 | | STS-135 |