EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the activity of urease (EC 3.5.1.5), reducing hydrolysis.
ChEBI ID: 50635
| Member | Definition | Class |
|---|---|---|
| acetohydroxamic acid | A member of the class of acetohydroxamic acids that is acetamide in which one of the amino hydrogens has been replaced by a hydroxy group. | acetohydroxamic acid; N-hydroxyacetimidic acid |
| monastrol | A racemate comprising equimolar amounts of R- and S-monastrol. | ethyl 4-(3-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate; monastrol |
| salicylhydroxamic acid | A hydroxamic acid that is N-hydroxybenzamide carrying a phenolic hydroxy group at position 2. | salicylhydroxamic acid |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 138 (22.51) | 18.7374 |
| 1990's | 73 (11.91) | 18.2507 |
| 2000's | 189 (30.83) | 29.6817 |
| 2010's | 184 (30.02) | 24.3611 |
| 2020's | 29 (4.73) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 5 (0.76%) | 5.53% |
| Reviews | 23 (3.50%) | 6.00% |
| Case Studies | 5 (0.76%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 625 (94.98%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 1.1220 | 1 | 1 |
| apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 8.9125 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 0.1188 | 1 | 1 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 20.8114 | 1 | 2 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 28.1838 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 100.0000 | 1 | 1 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 0.0347 | 1 | 1 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 1.0000 | 2 | 3 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 38.9018 | 1 | 1 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 11.9172 | 1 | 2 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 0.1059 | 1 | 1 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 23.7101 | 1 | 1 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 1.9953 | 1 | 1 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 0.1163 | 4 | 4 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 0.3317 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 1.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 1.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 1.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 1.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 1.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 1.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 1.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 1.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 1.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 1.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 1.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 1.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 1.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 1.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 1.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 1.0000 | 1 | 2 |
| geminin | Homo sapiens (human) | Potency | 2.5929 | 1 | 1 |
| GLS protein | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 19.9526 | 1 | 3 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 3.9811 | 2 | 2 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 125.8920 | 1 | 1 |
| lysosomal alpha-glucosidase preproprotein | Homo sapiens (human) | Potency | 9.9237 | 1 | 1 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| polyprotein | Zika virus | Potency | 0.3317 | 1 | 1 |
| progesterone receptor | Homo sapiens (human) | Potency | 10.6612 | 2 | 2 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 14.9601 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 10.0341 | 2 | 2 |
| snurportin-1 | Homo sapiens (human) | Potency | 125.8920 | 1 | 1 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 3.9811 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 10.4503 | 2 | 3 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 0.1259 | 1 | 1 |
| Vpr | Human immunodeficiency virus 1 | Potency | 63.0957 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 72 kDa type IV collagenase | Homo sapiens (human) | IC50 | 15,000.0000 | 1 | 1 |
| Alternative oxidase, mitochondrial | Trypanosoma brucei brucei | IC50 | 5.9300 | 1 | 1 |
| Aurora kinase A | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Carbonic anhydrase 2 | Homo sapiens (human) | IC50 | 47.0000 | 3 | 3 |
| Histone deacetylase 1 | Homo sapiens (human) | IC50 | 625.0000 | 2 | 2 |
| Kinesin-like protein KIF11 | Homo sapiens (human) | IC50 | 12.8247 | 9 | 9 |
| Kinesin-like protein KIFC1 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Lactoperoxidase | Bos taurus (cattle) | IC50 | 1.2000 | 1 | 2 |
| Lethal factor | Bacillus anthracis | IC50 | 11,400.0000 | 1 | 1 |
| Myeloperoxidase | Homo sapiens (human) | IC50 | 14.0000 | 2 | 2 |
| Peptide deformylase | Staphylococcus aureus subsp. aureus Mu50 | IC50 | 100.0000 | 1 | 1 |
| Polyunsaturated fatty acid 5-lipoxygenase | Rattus norvegicus (Norway rat) | IC50 | 30.0998 | 2 | 2 |
| Succinyl-diaminopimelate desuccinylase | Haemophilus influenzae Rd KW20 | IC50 | 1,000.0000 | 1 | 1 |
| Thyroid peroxidase | Homo sapiens (human) | IC50 | 1.2000 | 1 | 2 |
| Urease | Canavalia ensiformis (jack bean) | IC50 | 36.0000 | 4 | 4 |
| Urease | Canavalia ensiformis (jack bean) | Ki | 25.6600 | 1 | 1 |
| Urease subunit alpha | Escherichia coli | IC50 | 29.2000 | 1 | 1 |
| Urease subunit alpha | Helicobacter pylori 26695 | IC50 | 61.0238 | 24 | 24 |
| Urease subunit alpha | Helicobacter pylori 26695 | Ki | 96.0000 | 1 | 1 |
| Urease subunit beta | Escherichia coli | IC50 | 29.2000 | 1 | 1 |
| Urease subunit beta | Helicobacter pylori 26695 | IC50 | 58.4596 | 23 | 23 |
| Urease subunit beta | Helicobacter pylori 26695 | Ki | 96.0000 | 1 | 1 |
| Urease subunit beta | Helicobacter pylori | IC50 | 17.2000 | 1 | 1 |
| Urease subunit gamma | Escherichia coli | IC50 | 29.2000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Myeloperoxidase | Homo sapiens (human) | Kd | 2.0000 | 1 | 1 |
| Stromelysin-1 | Homo sapiens (human) | Kd | 17,000.0000 | 3 | 3 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Collagenase 3 | Homo sapiens (human) | Kb | 1.2000 | 1 | 1 |
| Peptidylglycine alpha-amidating monooxygenase | Rattus norvegicus (Norway rat) | Kis | 300.0000 | 1 | 1 |