Any compound that protects plants by activating their defence mechanisms.
ChEBI ID: 73182
| Member | Definition | Class |
|---|---|---|
| aspirin | A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity. | acetylsalicylic acid |
| oryzemate | A member of the class of 1,2-benzothiazoles that is 1,2-benzothiazole 1,1-dioxide substituted at position 3 by an allyloxy group. A fungicide used to control rice blast. | probenazole |
| s-methyl benzo(1,2,3)thiadiazole-7-carbothioate | A benzothiadiazole that is the S-methyl thioester derivative of acibenzolar. A profungicide (by hydrolysis of the thioester group to give the corresponding carboxylic acid), it is used as a fungicide and plant activator on a variety of crops, including cotton, chili peppers, lettuce, onions, spinach, tobacco, and tomatoes. | acibenzolar-S-methyl |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 13,926 (30.20) | 18.7374 |
| 1990's | 6,941 (15.05) | 18.2507 |
| 2000's | 10,269 (22.27) | 29.6817 |
| 2010's | 11,196 (24.28) | 24.3611 |
| 2020's | 3,787 (8.21) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 6,817 (13.89%) | 5.53% |
| Reviews | 7,014 (14.29%) | 6.00% |
| Case Studies | 3,483 (7.10%) | 4.05% |
| Observational | 445 (0.91%) | 0.25% |
| Other | 31,310 (63.81%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 33.5520 | 1 | 2 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 51.7099 | 3 | 3 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 23.1404 | 4 | 4 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 0.0028 | 2 | 2 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 33.9972 | 1 | 2 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 1.9953 | 1 | 1 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 12.5893 | 1 | 2 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 15.4871 | 1 | 1 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 2.7540 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 0.1727 | 1 | 1 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 76.4895 | 1 | 1 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 0.0224 | 1 | 1 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 14.9223 | 4 | 4 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 48.5577 | 1 | 1 |
| GLS protein | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 0.3548 | 1 | 1 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 2.8184 | 1 | 1 |
| hypothetical protein, conserved | Trypanosoma brucei | Potency | 50.1187 | 1 | 1 |
| IDH1 | Homo sapiens (human) | Potency | 0.4611 | 1 | 1 |
| interleukin 8 | Homo sapiens (human) | Potency | 74.9780 | 1 | 1 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 31.6228 | 1 | 1 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 2.2387 | 1 | 1 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 8.4127 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 15.4572 | 2 | 2 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 10.8951 | 1 | 1 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 56.2341 | 1 | 1 |
| progesterone receptor | Homo sapiens (human) | Potency | 54.4827 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 13.6922 | 2 | 2 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 16.5991 | 2 | 3 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 0.0501 | 2 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 4-aminobutyrate aminotransferase, mitochondrial | Rattus norvegicus (Norway rat) | IC50 | 2.4000 | 1 | 2 |
| Adenosine receptor A1 | Rattus norvegicus (Norway rat) | IC50 | 5,000.0000 | 1 | 1 |
| Adenosine receptor A2a | Rattus norvegicus (Norway rat) | IC50 | 5,000.0000 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 134.0000 | 2 | 2 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Carbonic anhydrase 1 | Homo sapiens (human) | IC50 | 2,710.0000 | 1 | 1 |
| Carbonic anhydrase 1 | Homo sapiens (human) | Ki | 7,530.0000 | 1 | 1 |
| Carbonic anhydrase 2 | Homo sapiens (human) | IC50 | 1,160.0000 | 1 | 1 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 3,660.0000 | 1 | 1 |
| Epidermal growth factor receptor | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Fatty acid-binding protein, liver | Rattus norvegicus (Norway rat) | Ki | 2,064.0000 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | IC50 | 0.3500 | 1 | 1 |
| Glutathione hydrolase 1 proenzyme | Homo sapiens (human) | IC50 | 36.0000 | 1 | 1 |
| Integrin alpha-IIb | Homo sapiens (human) | IC50 | 52.5000 | 2 | 2 |
| Integrin beta-3 | Homo sapiens (human) | IC50 | 52.5000 | 2 | 2 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Myeloperoxidase | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| Nicotinate phosphoribosyltransferase | Homo sapiens (human) | Ki | 0.0005 | 1 | 1 |
| Prostaglandin G/H synthase 1 | Homo sapiens (human) | IC50 | 337.1452 | 10 | 10 |
| Prostaglandin G/H synthase 1 | Ovis aries (sheep) | IC50 | 1,813.8445 | 37 | 40 |
| Prostaglandin G/H synthase 1 | Homo sapiens (human) | Ki | 62.0000 | 1 | 1 |
| Prostaglandin G/H synthase 1 | Bos taurus (cattle) | IC50 | 2,018.7250 | 5 | 6 |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | IC50 | 907.5235 | 24 | 26 |
| Prostaglandin G/H synthase 2 | Ovis aries (sheep) | IC50 | 523.7468 | 22 | 22 |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | Ki | 52.0000 | 1 | 1 |
| Prostaglandin G/H synthase 2 | Bos taurus (cattle) | IC50 | 1,500.0000 | 1 | 2 |
| Prostaglandin-H2 D-isomerase | Mus musculus (house mouse) | IC50 | 1,500.0000 | 1 | 1 |
| Rho-associated protein kinase 2 | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 2 |
| Seed linoleate 13S-lipoxygenase-1 | Glycine max (soybean) | IC50 | 1.3750 | 1 | 2 |
| Solute carrier family 22 member 20 | Mus musculus (house mouse) | Ki | 101.6645 | 1 | 2 |
| Solute carrier family 22 member 6 | Mus musculus (house mouse) | Ki | 689.4155 | 1 | 2 |
| Solute carrier family 22 member 6 | Rattus norvegicus (Norway rat) | Ki | 428.0000 | 1 | 1 |
| Substance-P receptor | Cavia porcellus (domestic guinea pig) | IC50 | 2.4000 | 1 | 1 |
| Urotensin-2 receptor | Rattus norvegicus (Norway rat) | IC50 | 0.3000 | 1 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| cell division cycle 42 (GTP binding protein, 25kDa), partial | Homo sapiens (human) | EC50 | 30.0000 | 2 | 2 |
| Chain A, Phospholipase A2 isoform 3 | Naja sagittifera | Kd | 6.4000 | 1 | 1 |
| GTP-binding protein (rab7) | Canis lupus familiaris (dog) | EC50 | 30.0000 | 1 | 1 |
| Rac1 protein | Homo sapiens (human) | EC50 | 30.0000 | 2 | 2 |
| ras protein, partial | Homo sapiens (human) | EC50 | 30.0000 | 2 | 2 |
| Ras-related protein Rab-2A | Canis lupus familiaris (dog) | EC50 | 30.0000 | 1 | 1 |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | EC50 | 30.0000 | 1 | 2 |
| Sigma non-opioid intracellular receptor 1 | Rattus norvegicus (Norway rat) | EC50 | 30.0000 | 2 | 2 |