Page last updated: 2024-08-05 15:28:06

EC 1.3.1.43 (arogenate dehydrogenase) inhibitor

An EC 1.3.1.* (oxidoreductase acting on CH-CH group of donor, NAD(+) or NADP(+) as acceptor) inhibitor that interferes with the action of arogenate dehydrogenase (EC 1.3.1.43).

ChEBI ID: 64416

Members (1)

MemberDefinitionClass
tyrosineAn optically active form of tyrosine having L-configuration.L-tyrosine zwitterion; L-tyrosine

Research

Studies (43,043)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-199012,108 (28.13)18.7374
1990's9,534 (22.15)18.2507
2000's12,285 (28.54)29.6817
2010's7,245 (16.83)24.3611
2020's1,871 (4.35)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials846 (1.91%)5.53%
Reviews1,754 (3.96%)6.00%
Case Studies680 (1.54%)4.05%
Observational23 (0.05%)0.25%
Other40,970 (92.54%)84.16%

Protein Targets (38)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
estrogen nuclear receptor alphaHomo sapiens (human)Potency33.491511

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Chain A, CHORISMATE MUTASESaccharomyces cerevisiae (brewer's yeast)Ki50.000011
Large neutral amino acids transporter small subunit 1Homo sapiens (human)IC5068.000011
Tubulin--tyrosine ligaseHomo sapiens (human)Ki25.000011

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Chain A, TYROSYL-tRNA SYNTHETASEGeobacillus stearothermophilusKd11.600011

Other Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Adenosine receptor A1Rattus norvegicus (Norway rat)KA0.011011
Adenosine receptor A2aRattus norvegicus (Norway rat)KA0.011012
Carbonic anhydraseCandida albicans SC5314KA46.100011
Carbonic anhydraseMethanosarcina thermophilaKA24.000011
Carbonic anhydraseMethanothermobacter thermautotrophicus str. Delta HKa10.500011
Carbonic anhydraseSaccharomyces cerevisiae S288CKa85.000022
Carbonic anhydrase Cryptococcus neoformans var. grubiiKA29.500011
Carbonic anhydrase Nakaseomyces glabratus CBS 138Ka9.500011
Carbonic anhydrase 1Homo sapiens (human)KA0.02001111
Carbonic anhydrase 12Homo sapiens (human)KA25.800011
Carbonic anhydrase 14Homo sapiens (human)KA21.800011
Carbonic anhydrase 15Mus musculus (house mouse)KA8.900011
Carbonic anhydrase 2Homo sapiens (human)Ka0.01101313
Carbonic anhydrase 3Homo sapiens (human)Ka34.100022
Carbonic anhydrase 4Homo sapiens (human)KA25.100022
Carbonic anhydrase 5A, mitochondrialHomo sapiens (human)KA2.450011
Carbonic anhydrase 5B, mitochondrialHomo sapiens (human)KA0.044011
Carbonic anhydrase 6Homo sapiens (human)KA9.310022
Carbonic anhydrase 7Homo sapiens (human)KA20.300011
Carbonic anhydrase 9Homo sapiens (human)KA25.300011
Carbonic anhydrase-like protein, putativeTrypanosoma cruzi strain CL BrenerKA4.920011
Glutamate receptor ionotropic, NMDA 1 Rattus norvegicus (Norway rat)KA20.300011
Glutamate receptor ionotropic, NMDA 2A Rattus norvegicus (Norway rat)KA20.300011
Glutamate receptor ionotropic, NMDA 2BRattus norvegicus (Norway rat)KA20.300011
Glutamate receptor ionotropic, NMDA 2CRattus norvegicus (Norway rat)KA20.300011
Glutamate receptor ionotropic, NMDA 2DRattus norvegicus (Norway rat)KA20.300011
Glutamate receptor ionotropic, NMDA 3ARattus norvegicus (Norway rat)KA20.300011
Glutamate receptor ionotropic, NMDA 3BRattus norvegicus (Norway rat)KA20.300011
Monocarboxylate transporter 10Rattus norvegicus (Norway rat)Km2,590.000011
Plasma kallikreinHomo sapiens (human)KA0.044011
Polyphenol oxidase 2Agaricus bisporusKm230.000022
SLC16A10 proteinHomo sapiens (human)Km636.300011
Taste receptor type 2 member 14Homo sapiens (human)Activity1,000.000011