ascorbic-acid and Rhinitis

Topics: Administration, Oral; Adolescent; Adult; Aged; Aminopyrine; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Ascorbic Acid; Capsules; Child; Child, Preschool; Delayed-Action Preparations; Double-Blind Method; Drug Combinations; Drug Evaluation; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Nasal Decongestants; Nylidrin; Piperidines; Rhinitis; Rhinitis, Allergic, Seasonal; Rutin

Topics: Aged; Aminopyrine; Ascorbic Acid; Clinical Trials as Topic; Drug Synergism; Humans; Male; Middle Aged; Piperidines; Rhinitis; Rutin; Vasodilator Agents

Topics: Aged; Aminopyrine; Ascorbic Acid; Bufanolides; Clinical Trials as Topic; Delayed-Action Preparations; Hearing; Humans; Middle Aged; Piperidines; Rhinitis; Rutin; Taste

Topics: Adult; Ascorbic Acid; Chronic Disease; Humans; Immunity; Interleukin-10; Nasal Polyps; Rhinitis; Sinusitis

We evaluated associations between three a-cellular measures of the oxidative potential (OP) of particulate matter (PM) and acute health effects.. We exposed 31 volunteers for 5 h to ambient air pollution at five locations: an underground train station, two traffic sites, a farm and an urban background site. Each volunteer visited at least three sites. We conducted health measurements before exposure, 2 h after exposure and the next morning. We measured air pollution on site and characterised the OP of PM2.5 and PM10 using three a-cellular assays; dithiotreitol (OP(DTT)), electron spin resonance (OP(ESR)) and ascorbic acid depletion (OP(AA)).. In single-pollutant models, all measures of OP were significantly associated with increases in fractional exhaled nitric oxide and increases in interleukin-6 in nasal lavage 2 h after exposure. These OP associations remained significant after adjustment for co-pollutants when only the four outdoor sites were included, but lost significance when measurements at the underground site were included. Other health end points including lung function and vascular inflammatory and coagulation parameters in blood were not consistently associated with OP.. We found significant associations between three a-cellular measures of OP of PM and markers of airway and nasal inflammation. However, consistency of these effects in two-pollutant models depended on how measurements at the underground site were considered. Lung function and vascular inflammatory and coagulation parameters in blood were not consistently associated with OP. Our study, therefore, provides limited support for a role of OP in predicting acute health effects of PM in healthy young adults.

Topics: Adult; Ascorbic Acid; Biomarkers; Breath Tests; C-Reactive Protein; Cities; Dithiothreitol; Electron Spin Resonance Spectroscopy; Environmental Exposure; Female; Fibrinogen; Forced Expiratory Volume; Humans; Hydroxyl Radical; Interleukin-6; Lactoferrin; Male; Nasal Lavage Fluid; Nitric Oxide; Oxidative Stress; Particulate Matter; Plasminogen Activator Inhibitor 1; Platelet Count; Railroads; Rhinitis; Tissue Plasminogen Activator; Vital Capacity; von Willebrand Factor; Young Adult

Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents; Ascorbic Acid; Humans; Infant, Newborn; Infant, Newborn, Diseases; Rhinitis; Vasodilator Agents

Topics: Ascorbic Acid; Caffeine; Common Cold; Diphenhydramine; Humans; Immune Tolerance; Nasal Decongestants; Pheniramine; Phenylephrine; Rhinitis; Rhinitis, Allergic, Seasonal; Vasoconstrictor Agents

Topics: Ascorbic Acid; Humans; Respiratory System; Respiratory Tract Diseases; Rhinitis; Sympathomimetics

Topics: Ascorbic Acid; Desoxycorticosterone; Desoxycorticosterone Acetate; Rhinitis; Rhinitis, Allergic; Rhinitis, Vasomotor; Vitamins