Excerpt | Reference |
"Cancer of the colon is subject to somewhat different controlling elements than cancer of the breast because of the nature of the cell kinetics governing these tissues." | ( Weisburger, JH, 1979) |
"Incidence rate of colon cancer is low in India compared to the Western countries." | ( Gangadharan, P; Jussawalla, DJ, 1977) |
"Screening for colon cancer is discussed with a selective diagnostic approach and with emphasis on this approach in early diagnosis of asymptomatic high risk patients." | ( Copeland, MM, 1976) |
"Human colon cancer is resistant to a variety of alkylating agents including the nitrosoureas." | ( Arce, C; Berger, NA; Gerson, SL; Petzold, SJ; Willson, JK, 1992) |
"Colon cancer is the second most common type of cancer in the United States." | ( Bernstein, H; Cheah, PY, 1990) |
"Colon cancer is one of the tumors most refractory to treatment by chemotherapy, and this may be due to inherent phenotypic instability of such tumor cells with respect to the biochemical determinants of drug sensitivity." | ( Cheng, YC; Ferguson, PJ, 1989) |
"Preclinical colon cancer is associated with a further decrease in serum cholesterol levels." | ( Broitman, SA, 1986) |
"The incidence of colon cancer is increasing in Sweden." | ( Mellström, D; Rundgren, A, 1983) |
"Rat colon neoplasms are distributed 60% in the distal colon (DC) and 40% in the proximal colon (PC), similar to distribution of colon cancers in the industrialized world." | ( Holt, PR; Liu, T; Mokuolu, AO; Rao, CV; Reddy, BS, 1995) |
"Colon cancer is associated with elevated levels of PGE2, while aspirin, the prototypical inhibitor of PG synthesis, appears to reduce the incidence of colon cancer by 50%." | ( Arvind, P; Duceman, B; Lovelace, CI; Papavassiliou, ED; Qiao, L; Rigas, B; Tsioulias, GJ, 1995) |
"Human colon cancer is associated with antigenic and structural changes in mucin-type carbohydrate chains (O-glycans)." | ( Brockhausen, I; Byrd, JC; Chung, YS; Kim, YS; Matta, KL; Okuno, M; Siddiki, BB; Sowa, M; Yang, JM, 1994) |
"Colon cancer is one of the major health problems in industrialized countries, and its incidence appears to be increasing." | ( Aquino, A; Armenio, S; Civitelli, S; Francini, G; Lorenzini, L; Mancini, S; Marsili, S; Marzocca, G; Petrioli, R; Tanzini, G, 1994) |
"Human colonic cancer is associated with multiple genetic deletions, mutations, and alterations in gene expression; in contrast, gene amplification has not been recognized as a prominent characteristic of human colonic tumors." | ( Augenlicht, LH; Benson, A; Corner, G; Haller, D; Heerdt, BG; Multani, AS; Pathak, S; Richards, C; Ryan, L; Wadler, S, 1997) |
"Colon cancer is the second most common cause of cancer mortality." | ( Bohdiewicz, PJ, 1998) |
"Human colon cancer is a multistage disease which has been shown to have a number of well-defined histological and genetic events." | ( Davies, MJ; Rumsby, PC, 1998) |
"Colon cancer is one of the commonest cancers in the Western world." | ( Holt, PR, 1999) |
"Colon cancer is the third most common newly diagnosed cancer in the United States and the third most common cause of cancer-related deaths." | ( Davis, CD; Feng, Y; Finley, JW, 2000) |
"Colon cancer is the third leading class of cancer causing increased mortality in developed countries." | ( Argov, S; Goldstein, J; Guterman, H; Mordechai, S; Ramesh, J; Salman, A; Sinelnikov, I, 2002) |
"The risk of colon cancer is decreased among current and recent users of postmenopausal HRT but the molecular mechanisms involved remain unclear." | ( al-Azzawi, F; Wahab, M, 2002) |
"Colon cancer is one of the most common forms of malignant tumors in humans, and its incidence is increasing." | ( Manju, V; Menon, VP; Nalini, N, 2004) |
"The incidence of colon cancer is high in many developed nations, especially New Zealand." | ( Ferguson, LR; Karunasinghe, N; Philpott, M, 2004) |
"Metastatic colon cancer is frequent and often simulates ovarian endometrioid adenocarcinoma." | ( Prat, J, 2005) |
"Colon cancer is one of the highest incidence rates throughout the world and some evidences have indicated carotenoids as possible agents that decrease the risk of colorectal cancer." | ( Agner, AR; Bazo, AP; Ribeiro, LR; Salvadori, DM, 2005) |
"The development of colon cancer is characterised by alterations in multiple genetic and epigenetic pathways in colon tissue leading ultimately to deregulation of colon epithelial cells." | ( Arthur, JR; Drew, JE; Duncan, G; Duthie, GG; Farquharson, AJ; Lufty, A; Morrice, PC; Reid, MD; Rucklidge, GJ; Russell, WR, 2005) |
"Colon cancer is the second leading cause of cancer death in the United States, whereas cancer of the small intestine is relatively rare." | ( Chapkin, RS; Donnelly, KC; Lupton, JR; Popovic, N; Turner, ND; Zhou, GD, 2005) |
"Colon cancer is the third most common cancer and second leading cause of cancer-related death in the United States." | ( Balasubramaniyan, V; Manju, V; Nalini, N, 2005) |
"Colon cancer is one of the most common malignancies in many regions of the world and is thought to arise from the accumulation of mutations in a single epithelial cell of the colon and rectum." | ( Deeptha, K; Kamaleeswari, M; Nalini, N; Sengottuvelan, M, 2006) |
"Colon cancer is a leading cause of cancer and cancer deaths in Western countries." | ( Cilley, J; Mulcahy, MF, 2006) |
"Mortality from colon cancer is significant with an expected 30,350 colon cancer deaths in 2005 with current treatment(s)." | ( Alli, AA; Gower, WR; Vesely, BA; Vesely, DL, 2005) |
"Colon cancer is the second most common cancer among men and women worldwide." | ( Manju, V; Menon, VP; Nalini, N, 2006) |
"Colon cancer is a leading cause of cancer death and its prevention is of great interest throughout the world." | ( Kamaleeswari, M; Nalini, N, 2006) |
"Colon cancer is becoming increasingly common in Asian countries and still remains the second leading cause of cancer death in the United States." | ( Manju, V; Nalini, N, 2006) |
"Colon cancer is c-kit positive and responsive to the specific tyrosine kinase inhibitor imatinib." | ( Chalkiadakis, G; Kanakis, I; Karamanos, NK; Kletsas, D; Mavroudis, D; Roussidis, AE; Stahtea, XN; Tzanakakis, GN, 2007) |
"Colon cancer is the third most malignant neoplasm in the world and it remains today an important cause of death, especially in western countries." | ( Namasivayam, N; Sreedharan, V; Venkatachalam, KK, 2009) |
"Colon cancer is a major cause of morbidity and mortality in developed and developing countries." | ( Nalini, N; Sengottuvelan, M; Srihari, T, 2008) |
"Colon cancer is a public health problem worldwide." | ( Duhoux, F; Mano, MS, 2008) |
"Colon cancer is still one of the leading causes of death in USA and is increasing at an alarming rate in Asia." | ( Aranganathan, S; Nalini, N; Panneer Selvam, J, 2009) |
"Colon cancer is also associated with the expression of pyruvate kinase M2, a splice variant with low catalytic activity." | ( Carswell, KN; Ganapathy, V; Prasad, PD; Thangaraju, M, 2009) |
"Colon cancer is one of the leading causes of cancer death in men and women in Western countries." | ( Rimando, AM; Suh, N, 2008) |
"Colon cancer is a major cause of morbidity and mortality in developed and developing countries and its etiology is known to be a combination of hereditary, environmental, dietary factors and lack of physical activity." | ( Giftson, JS; Jayanthi, S; Nalini, N, 2010) |
"Colon cancer is a serious health problem in most of the countries and is the leading cause of cancer mortality throughout the world." | ( Aranganathan, S; Gopalan, R; Nalini, N; Selvam, JP, 2009) |
"Colon cancer is the third most common cancer and third most common cause of cancer-related death in the USA according to 2008 American Cancer Society statistics." | ( Chen, J; Huang, XF, 2009) |
"Colon cancer is one of the major causes of cancer mortality worldwide." | ( Ashokkumar, P; Prabhu, PN; Sudhandiran, G, 2009) |
"Colon cancer is the second leading cause of cancer death worldwide." | ( Babaei, MH; Ghannadi Maragheh, M; Mesbah-Namin, SA; Taghikhani, M; Yavari, K, 2010) |
"Progression of colon cancer is associated with the up-regulation of cyclooxygenase-2 (COX-2) and hydroxymethyl glutaryl CoA reductase (HMG-R)." | ( Guruswamy, S; Rao, CV, 2009) |
"Colon cancer is the third most malignant neoplasm in the world and it remains an important cause of mortality in Asian and Western countries." | ( Nagendraprabhu, P; Sudhandiran, G, 2011) |
"Colon cancer is a major cause of cancer deaths." | ( Aluri, L; Badal, S; Bissonnette, M; Cerasi, D; Cerda, S; Delgado, J; Dougherty, U; Fichera, A; Hart, J; Joseph, L; Kocherginsky, M; Mustafi, R; Sehdev, A; Taylor, I; Tekin, U; Threadgill, D; Zhu, H, 2009) |
"Colon cancer is one of the most common malignant tumors, and its pathogenesis is not fully understood." | ( Huo, JR; Ren, JZ, 2010) |
"Colon cancer is the third and fourth most prevalent cancer among Iranian men and women, respectively." | ( Amanzadeh, A; Azadmanesh, K; Teimoori-Toolabi, L; Zeinali, S, 2010) |
"Colon cancer is the leading cause of cancer death in both men and women worldwide." | ( Ramana, KV; Srivastava, SK; Tammali, R, 2010) |
"Since colon cancer is highly sensitive to dietary intervention adults who may have preneoplastic lesions in their colon may be benefited by silibinin." | ( Aranganathan, S; Nalini, N; Panneerselvam, J; Rama, G; Sangeetha, N; Shanthi, P, 2010) |
"Colon cancer is the third leading cause of cancer-related deaths worldwide." | ( Graham, B; Rogers, C; Stevens, JJ; Tchounwou, PB; Walker, AM, 2010) |
"Colon cancer is a common malignant tumor that is associated with increased morbidity and mortality." | ( Guo, Q; Lian, P; Liao, M; Shen, S; Wang, X, 2010) |
"Colon cancer is the fourth most common cancer globally with 639,000 deaths reported annually." | ( Colombo, G; Sonvico, F; Wong, TW, 2011) |
"Colon cancer is a public health problem worldwide." | ( Aravantinos, G; Bafaloukos, D; Bamias, A; Basdanis, G; Dimopoulos, MA; Economopoulos, T; Efstratiou, I; Fountzilas, G; Kafiri, G; Kalofonos, HP; Karanikiotis, C; Karina, M; Klouvas, G; Korantzis, I; Makatsoris, T; Malettou, L; Matsiakou, F; Miliaras, D; Papadimitriou, CA; Papakostas, P; Papaspirou, I; Pectasides, D; Pentheroudakis, G; Pisanidis, N; Samantas, E; Xiros, N, 2011) |
"Colon cancer is the third most malignant neoplasm in the world and chemoprevention through dietary intervention is an emerging option to reduce its mortality." | ( Sudhandiran, G; Umesalma, S, 2011) |
"Colon cancer is the third leading cause of cancer deaths in men and women." | ( Das, UN; Radhakrishnan, S; Reddivari, L; Sclafani, R; Vanamala, J, 2011) |
"Colon cancer is the third most common cause of cancer and is the second leading cause of cancer deaths in the USA." | ( Awasthi, S; Evers, BM; Qiu, S; Ramana, KV; Reddy, AB; Rychahou, PG; Saxena, A; Srivastava, SK; Tammali, R, 2011) |
"Colon cancer is a leading cause of cancer deaths in Western countries and is associated with diets high in red meat." | ( de Wit, N; Dekker, J; IJssennagger, N; Jonker-Termont, D; Müller, M; Rijnierse, A; van der Meer, R, 2012) |
"Colon cancer is one of the most common human cancers worldwide." | ( Chang, JL; Chen, TC; Ho, JY; Wang, TH; Wu, HC, 2012) |
"Colon cancer is one of the serious health problems in most developed countries and its incidence rate is increasing in India." | ( Akbarsha, MA; Bernini, R; Menon, VP; Nalini, N; Preethy, CP; Riyasdeen, A; Sivagami, G; Vinothkumar, R, 2012) |
"Colon cancer is one of the most common malignancies, mainly initiated by the abnormal activation of Wnt/β-catenin signaling." | ( He, B; Liu, Y; Mu, Y; Wu, K; Yang, Q; Zhou, L; Zhou, Q, 2012) |
"Colon cancer is the second most common cause of cancer death in Iceland and accounts for 8% of malignancies." | ( Alexiusdottir, KK; Björnsson, ES; Jonasson, JG; Jonasson, L; Möller, PH; Olafsdottir, EJ; Snaebjornsson, P; Tryggvadottir, L, 2012) |
"The model of distal colon cancer is feasible." | ( Abrantes, AM; Batista, JN; Botelho, MF; Cardinalli, IA; Neves, S; Priolli, DG, 2012) |
"Colon cancer is one of the most common malignances." | ( Ding, M; Du, JL; Pan, JY; Wen, G; Weng, XL; Yu, ML; Zhao, F; Zhao, J, 2012) |
"Colon cancer is the third most common cancer and one of the leading causes of cancer-related death in the world." | ( Li, J; Xiong, Y; Xu, W; Yan, Z; Zheng, G, 2012) |
"Colon cancer is associated with a poor prognosis, motivating strategies to prevent its development." | ( Ha, J; Kim, EJ; Ko, YG; Lee, M; Lee, YJ; Park, JJ; Seo, SM, 2012) |
"Colon cancer is the third most common malignancy around the world." | ( Cha, EY; Kim, JY; Lee, JS; Lee, MS; Park, JB; Song, IS; Sul, JY, 2012) |
"Colon cancer is the third most common malignant neoplasm in the world and it remains an important cause of death, especially in western countries." | ( Ali, F; Hamiza, OO; Khan, AQ; Khan, R; Lateef, A; Rehman, MU; Sultana, S; Tahir, M, 2012) |
"Colon cancer is a common malignant neoplasm causing huge morbidity and mortality worldwide." | ( Chitra, P; Manikandan, R; Saiprasad, G; Sudhandiran, G, 2013) |
"Colon cancer is one of the most commonly diagnosed cancers in the United States." | ( Debnath, B; Garofalo, A; Grande, F; Imada, T; Masuda, M; Neamati, N; Oshima, T; Xu, S, 2013) |
"Colon cancer is among the most common cancers in the United States, and the median age of patients at diagnosis is 70." | ( Goldberg, RM; Wu, C, 2013) |
"Colon cancer is one of the major malignancies worldwide and it still remains resistant to much of the currently available chemotherapy." | ( Feng, Y; Gao, SH; Liu, C; Wei, J, 2013) |
"Colon cancer is the leading cause of morbidity and mortality worldwide." | ( Dharmalingam, P; Ganapasam, S; Munusamy, A; Pandurangan, AK; Ramar, M; Sadagopan, SK, 2013) |
"Colon cancer is a disease of the elderly and accordingly, there is a large subgroup of patients for which guidelines for adjuvant treatment remain less clear." | ( Ågesen, TH; Guren, MG; Lothe, RA; Nesbakken, A; Skotheim, RI; Sveen, A; Tveit, KM, 2013) |
"Colon cancer is a malignancy that develops in colon and rectal tissues." | ( Haniu, H; Matsuda, Y; Tsukahara, T, 2013) |
"Colon cancer is still the second leading cause of cancer deaths in the United States." | ( Knackstedt, RW; Morris, J; Moseley, VR; Wargovich, MJ, 2013) |
"Colon cancer is a major public health problem." | ( Borrelli, F; Cascio, MG; Izzo, AA; Pagano, E; Pertwee, RG; Romano, B, 2014) |
"Colon cancer is the third most global oncologic problem faced by medical fraternity." | ( Balasubramanian, T; Nalini, N; Sudha, M; Vinoth Kumar, R; Vinothkumar, R; Viswanathan, P, 2014) |
"Colon cancer is one of the third most common cancer in man, the second most common cancer in women worldwide, and the second leading cause of mortality in the USA." | ( Ramamoorthi, G; Sivalingam, N, 2014) |
"Colon cancer is one of the most common malignancies and the treatments for colon cancer have been developed substantially in the last decades, but there is still a great clinical need to explore new treatment regimens due to the undesirable prognosis." | ( Chen, L; Deng, ZL; He, BC; Huang, J; Liu, Y; Liu, YZ; Luo, JY; Meng, ZJ; Sun, WJ; Wang, DX; Wang, X; Wu, K; Yang, JQ; Yin, LJ; Yuan, SX; Zuo, GW, 2014) |
"Colon cancer is the third most leading causes of death due to cancer worldwide and the chemo drug 5-fluorouracil's (5-FU) applicability is limited due to its non-specificity, low bioavailability and overdose." | ( Anitha, A; Chennazhi, KP; Jayakumar, R; Lakshmanan, VK; Sreeranganathan, M, 2014) |
"Colon cancer is the third most common cancer and the third largest cause of cancer-related death." | ( Chen, J; Gu, W; Li, L; Shao, R; Xu, ZP, 2014) |
"Colon cancer is one of the most common cancers in both men and women." | ( Karthikkumar, V; Nalini, N; Sivagami, G; Viswanathan, P, 2015) |
"Colon cancer is one of the major causes of death in the Western world." | ( Corem-Salkmon, E; Grinberg, I; Kolitz-Domb, M; Margel, S, 2014) |
"Colon cancer is among the most dangerous tumors affecting humankind." | ( de Paula Garcia, W; Fernandes, CR; Frajacomo, FT; Garcia, SB; Kannen, V, 2015) |
"Colon cancer is associated with a high incidence and a poor prognosis." | ( Dong, L; Gao, Y; Huo, X; Sai, H; Sun, X; Wei, G; Wu, J; Xu, Y; Zhang, Y, 2015) |
"Colon cancer is a world concerning disease; it shows a high mortality rate and may be related to eating habits." | ( Aguirre-Riverab, JR; Andrade-Zaldívar, H; Dávila-Céspedes, A; Juárez-Flores, BI; Loyola-Martínez, ED; Oros-Ovalled, AC; Pinos-Rodríguezc, JM, 2014) |
"Colon cancer is one of the most common malignancies, causes considerable morbidity and mortality." | ( He, BC; Huang, J; Jin, JL; Sun, WJ; Wan, LH; Wang, DX; Wu, K; Wu, QX; Yang, JQ; Yuan, SX; Zhou, M, 2015) |
"Colon cancer is the second most lethal cancer." | ( Biddick, L; Dai, W; Lightfoot, S; Rao, CV; Reddy, A; Sanghera, S; Yamada, HY; Zhang, Y, 2016) |
"Colon cancer is one of the leading causes of cancer-associated death worldwide." | ( Dehghan Esmatabadi, MJ; Farhangi, B; Kazerooni, H; Sadeghizadeh, M; Safari, Z; Shirzad, H; Zolghadr, F, 2015) |
"Colon cancer is the third most common cancer in humans which has a high mortality rate, and 5-Fluorouracil (5-FU) is one of the most widely used drugs in colon cancer therapy." | ( Jin, Y; Lin, D; Pei, S; Wang, H; Yang, X; Zhang, D; Zhang, H; Zhang, L; Zhang, Y; Zhou, B, 2015) |
"Colon cancer is one of the most common tumors in the human population." | ( Alho, EJ; Friedrich, M; Garcia, SB; Gasser, M; Heinsen, H; Heinze, KG; Kannen, V; Mönch, R; Scholz, CJ; Silva, WA; Stopper, H; Waaga-Gasser, AM, 2015) |
"Stage III colon cancer is currently treated as an entity with a unified therapeutic principle." | ( Deng, G; He, J; Ma, J; Pei, H; Shen, H; Wu, X; Zeng, S; Zhang, S; Zhang, Y, 2015) |
"Colon cancer is one of the most common malignancies worldwide and has a high mortality rate." | ( Cao, Y; Fan, K; Li, L; Li, X; Qi, H; Sun, H; Zhang, Q, 2015) |
"Colon cancer is the third most common cause of death in the United States." | ( Alam, S; Ansari, KM; Kumar, R; Mir, SS; Pal, A, 2016) |
"Colon cancer is one of the most commonly diagnosed cancers, and is a major cause of cancer morbidity and mortality worldwide." | ( Arivalagan, S; Chandrasekaran, B; Kuppsamy, T; Mani, V; Namasivayam, N; Siddique, AI; Thomas, NS, 2015) |
"In this protocol, colon cancer is induced in mice through a series of injections with 1,2-dimethylhydrazine." | ( Gurley, KE; Kemp, CJ; Moser, RD, 2015) |
"Colon cancer is one of the most common cancers worldwide with high mortality." | ( Chen, J; Gu, W; Li, F; Liu, JP; Monteiro, M; Shao, R; Xu, ZP, 2015) |
"Colon cancer is one of the leading causes of cancer-related death worldwide, and the therapeutic application of 5-fluorouracil (5-FU) is limited due to its nonspecificity, low bioavailability, and overdose." | ( Huo, ZJ; Li, XC; Liu, K; Liu, P; Ma, Y; Qin, YH; Wang, SJ; Wang, ZQ, 2015) |
"Colon cancer is one of the most common malignancies." | ( Chen, QZ; Chen, ZH; He, BC; Huang, J; Li, Y; Ren, CM; Shao, Y; Sun, WJ; Wang, DX; Wu, K; Wu, QX; Yu, Y; Yuan, SX; Zeng, YH, 2015) |
"Colon cancer is the third most commonly diagnosed cancer and the second leading cause of cancer mortality worldwide." | ( Chen, M; Chen, W; Hu, S; Hui, J; Ji, J; Liang, G; Wang, Y; Xu, S; Zhou, J, 2015) |
"Colon cancer is one of the most common malignancies of the digestive system." | ( Bai, Y; Chen, QZ; He, BC; Li, Y; Ren, CM; Shao, Y; Sun, WJ; Wang, DX; Wu, K; Wu, QX; Yang, JQ; Yu, Y; Yuan, SX; Zeng, YH; Zhang, P, 2016) |
"Colon cancer is a frequently occurring primary malignant tumor." | ( Cai, S; Hu, J; Xu, Y, 2015) |
"Colon cancer is a common type of cancer with high mortality." | ( Chen, J; Han, M; Saif, MW, 2016) |
"The invasion of colon cancer is associated with the tumor angiogenesis." | ( Hu, TY; Lv, JY; Wang, G; Wang, RY; Zhu, JM, 2016) |
"Colon cancer is one of the leading causes of cancer death worldwide." | ( Adachi, N; Aoyama, H; Fujibayashi, Y; Furukawa, T; Saga, T; Wakizaka, H; Yoshii, Y; Zhang, MR, 2016) |
"Colon cancer is the third most common malignancy worldwide." | ( Chen, BC; Lien, GS; Lin, CH; Wu, MS; Yang, YL, 2016) |
"Colon cancer is one of the most common internal malignancies, and conventional chemotherapy is not effective in its treatment." | ( Divsalar, A; Izadi, Z; Saboury, AA; Sawyer, L, 2016) |
"Colon cancer is invariably accompanied by altered coagulation activity; however, the precise role of phosphatidylserine (PS) in the hypercoagulable state of colon cancer patients remains unclear." | ( Bi, Y; Kou, J; Piao, D; Shi, J; Zhao, L, 2016) |
"Colon cancer is the third most incident type of cancer worldwide." | ( Alcaide, A; Ávila-Román, J; de Carvalho, JE; Garcia-Mauriño, S; Motilva, V; Pelizzaro-Rocha, KJ; Pilli, RA; Talero, E; Vendramini-Costa, DB, 2016) |
"Colon cancer is the third most common cancer in the world, with drug resistance and metastasis being the major challenges to effective treatments." | ( Garcia Carcedo, I; Gu, W; Li, L; Monteiro, M; Xu, ZP; Zou, H, 2016) |
"Colon cancer is one of the leading causes of cancer mortality, worldwide." | ( Anandasadagopan, SK; Ganapasam, S; Sekar, V, 2016) |
"Colon cancer is one of the most incident cancers in the Western World." | ( Abrantes, AM; Botelho, MF; Carvalho, RA; Encarnação, JC; Fernandes, E; Freitas, M; Pires, AS; Proença, C; Roleira, FM; Tavares-da-Silva, EJ; Varela, CL, 2016) |
"Colon cancer is the third leading cause of cancer mortality worldwide, which results from interactions of different factors." | ( Mohamed, MI; Tawfik, MK, 2016) |
"BACKGROUND Colon cancer is one of the most prevalent and deadly cancers worldwide." | ( Hu, JC; Jiang, LX; Qu, Z; Sui, MH; Sun, HQ; Yu, X; Zhai, HY; Zheng, HT; Zhou, K, 2016) |
"Colon cancer is one of the leading causes of cancer-related death worldwide and the therapy with 5-fluorouracil (5-FU) is mainly limited due to resistance." | ( Budillon, A; Leone, A; Maiolino, S; Pagliara, V; Quaglia, F; Russo, A; Russo, G; Scalia, G; Tatangelo, F; Ungaro, F, 2016) |
"Colon cancer is a leading cause of cancer-related death in humans." | ( Spencer, NJ, 2016) |
"Colon cancer is still the third most common cancer which has a high mortality but low five-year survival rate." | ( Huang, X; Li, W; Tan, Z; Wang, H; Wang, J; Yu, R; Zhang, L; Zhang, Y; Zhong, J, 2017) |
"The risk of colon cancer is increased in patients with Crohn's disease and ulcerative colitis." | ( Bakthavatchalu, V; Bryant, EM; Conaway, EA; Fox, JG; Gong, G; Holcombe, H; Horwitz, BH; Muthupalani, S; Parry, NAP; Puglisi, DA; Sheh, A; Short, SP; Tannenbaum, SR; Wang, C; Williams, CS; Wogan, GN, 2017) |
"Colon cancer is one of the most widespread disease, the mortality rate is high due to cancer metastasis and the development of drug resistance." | ( Ghosh, B; Keshari, AK; Kumar, D; Kumar, U; Rai, A; Raj, V; Saha, S; Singh, AK; Trivedi, P, 2018) |
"Metastatic colon cancer is a major cause of deaths among colorectal cancer (CRC) patients." | ( Chen, H; Cui, H; Ignatenko, NA; Pandey, R; Sells, E; Skovan, BA, 2017) |
"Colon cancer is one of the most lethal varieties of cancer." | ( Gao, S; Li, C; Li, X; Ma, L, 2018) |
"Colon cancer is common worldwide and accounts for the significant cancer related morbidity and mortality in patients." | ( Chen, QZ; He, BC; He, F; Huang, M; Li, Y; Liao, YP; Ren, WY; Shao, Y; Wang, H; Wang, J; Wu, K; Zeng, YH; Zhou, LY; Zhu, JH, 2017) |
"Colon cancer is thought to develop in a stepwise fashion." | ( Clichici, S; Djerdjouri, B; Moulahoum, H; Nagy, AL, 2018) |
"Colon cancer is one of the leading causes of cancer-related deaths." | ( Bao, M; Chen, R; Dai, X; Dong, X; Liang, G; Shen, X; Sun, X; Vladimir, K; Zhuge, W; Zia, K, 2018) |
"Colon cancer is the third most common cancer, and yet there is a lack of effective therapeutic method with low side effects." | ( Wang, J; Yang, X; Yuan, S; Zhai, X; Zou, P, 2018) |
"Colon cancer is the most common type of gastrointestinal cancer." | ( Hanušová, V; Králová, V; Matoušková, P; Skálová, L, 2018) |
"Colon cancer is one of the most common digestive tumors." | ( Dai, GH; Mao, H; Wang, ZK; Wu, LL; Yang, L; Zhang, PF; Zhou, YH, 2017) |
"Colon cancer is a world-wide health problem and one of the most dangerous type of cancer, affecting both men and women." | ( Ahmad Ganaie, M; Ahmad, B; Ali, R; Bilal Ahmad, S; Farooq, A; Hussain, I; Madkhali, H; Masoodi, M; Muzamil, S; Rahman Mir, MU; Rashid, SM; Rehman, MU, 2018) |
"Colon cancer is the third most frequently diagnosed malignancy and has high morbidity worldwide." | ( Cheng, H; Fan, H; Li, L; Miao, Y; Shen, W; Sun, D; Tan, J; Xu, C; Yang, Y; Zhang, F; Zhang, H, 2018) |
"Colon cancer is a commonly diagnosed cancer that often has a poor prognosis." | ( Guo, J; Jiang, H; Jin, D; Li, K; Liu, C; Qin, C; Wu, Y, 2018) |
"Colon cancer is characterized by invasion and migration." | ( Ren, J; Tang, L; Zhu, J, 2018) |
"Colon cancer is the main cause of cancer mortality worldwide." | ( Jiang, Z; Kang, YJ; Wang, C; Wang, S; Xu, Y; Yang, H; Zhang, Y, 2018) |
"Colon cancer is the third most common malignancy in both sexes of Korea." | ( Kang, YR; Kawk, SH; Kim, YH, 2018) |
"Colon cancer is among the most widely occurring cancer types, leading to considerably high mortality rate." | ( Chen, Q; Han, MK; Kang, Y; Merlin, D; Viennois, E; Wan, Y; Wang, L; Xiao, B; Zhang, Y; Zhang, Z, 2018) |
"Colon cancer is common in the elderly, but owing to under representation in clinical trials, the benefit of standard therapies is uncertain in this age group." | ( Aghmesheh, M; Brungs, D; Carolan, M; Clingan, P; de Souza, P; Ranson, M; Rose, J, 2018) |
"Colon cancer is the most aggressive form of cancers, that causes 0." | ( Al-Buloshi, M; Bakshi, HA; Hakkim, FL; Hasson, SSAA; Javid, F; Krishnan, M; Kumar, NR; Nagarajan, K; Rashan, L; Revathi, S, 2018) |
"Colon cancer is a prevalent malignancy affecting the gastrointestinal tract." | ( He, BC; Hu, XL; Liao, YP; Liu, RX; Ma, Y; Ren, WY; Sun, WJ; Wang, H; Wu, K; Zhu, JH, 2018) |
"Colon cancer is a devastating illness that is associated with gut inflammation." | ( Balboa, MA; Balsinde, J; Cubero, Á; García-Rostán, G; Győrffy, B; Lordén, G; Meana, C; Orduña, A; Peña, L, 2018) |
"Colon cancer is the major health disease related with high mortality." | ( Khan, AQ; Khan, R; Rehman, MU; Sultana, S; Tahir, M, 2018) |
"Colon cancer is one of the most lethal and common malignancies worldwide." | ( Bak, Y; Hong, J; Jang, HJ; Kim, BY; Kwon, SB; Pham, TH; Yoon, DY, 2018) |
"BACKGROUND Colon cancer is one of the most common cancers and it is the fourth leading cause of cancer-related deaths worldwide." | ( Huang, Y; Tian, X; Wang, C; Xiong, P; Zhang, J; Zhao, B; Zhu, J, 2018) |
"Colon cancer is a common type of cancer worldwide and accounts for a significant number of cancer‑related deaths." | ( Bie, L; Chen, B; Chen, X; Deng, W; Guo, Y; Guo, Z; Jin, G; Li, D; Li, N; Liu, Y; Luo, S; Wang, G; Yao, K; Zhao, Z, 2019) |
"Colon cancer is one of the most common cancers in the developed countries." | ( Chang, WC; Cho, EC; Hung, WH; Yu, CY; Zheng, JH, 2018) |
"Colon cancer is one of the fatal forms of cancer all round the world with a equal frequency of occurrence in both male and female population." | ( Iqbal, Z; Mishra, H; Mishra, PK; Siddiqui, L; Talegaonkar, S, 2018) |
"Colon cancer is a common cause of cancer-related death worldwide." | ( Liu, JM; Lv, HZ; Wang, CC; Ye, XY; Zhang, F, 2018) |
"Diabetes and colon cancer are the leading cause of mortality worldwide." | ( Ambasta, RK; Bhattacharya, S; Gupta, R; Kumar, D; Kumar, P; Sarkar, A, 2018) |
"Colon cancer is one of the most frequently occurring types of cancers in the world." | ( Akimov, V; Badiola, I; Clerigué, AS; Ibarretxe, G; Kratchmarova, I; Marquez, J; Osinalde, N; Unda, F, 2019) |
"Human colon cancer is one of the higher aggressive solid tumors, whose high mortality, much like many other solid tumors, results from metastasis formation." | ( Cassata, G; Cavallaro, G; Cicero, L; Giammona, G; Licciardi, M; Puleio, R; Scialabba, C, 2019) |
"Colon cancer is one of the most common malignant tumors worldwide." | ( Li, X; Liu, KX; Wang, XM; Zhang, R; Zheng, XF, 2019) |
"Colon cancer is a major health problem worldwide." | ( Bai, R; Feng, T; Lv, W; Shi, Z; Yu, X; Yuan, M; Zhong, H, 2019) |
"Although colon cancer is one of the most important triggers of cancer related mortality, a few therapeutic options exist for this disease, including combination chemotherapy, anti-EGFR and anti-angiogenic agents." | ( Azizi, G; Ghalamfarsa, G; Hojjat-Farsangi, M; Jadidi-Niaragh, F; Karpisheh, V; Namdar, A; Nikkhoo, A; Sabz, G; Yousefi, B; Yousefi, M, 2019) |
"Colon cancer is one of the most common cancer around the world." | ( Aktas, B; Aslim, B; Tukenmez, U; Yavuz, S, 2019) |
"Colon cancer is one of the leading causes of cancer-related deaths." | ( Shao, R; Shen, H; Shen, X; Wang, B; Xia, Y; Zhang, J; Zhang, T; Zheng, P; Zou, P, 2019) |
"Colon cancer is one of the most lethal cancers worldwide even with the significant progress made in screening techniques and therapeutic agents." | ( Cho, EC; Hsieh, YC; Lin, MH; Wang, JS; Zheng, JH, 2019) |
"Colon cancer is a malignant type of cancer with high prevalence and is one of the primary causes of cancer-related deaths." | ( Cao, P; Cui, R; He, W; Hong, L; Liang, G; Shen, X; Xia, Y; Zhang, T; Zheng, P; Zou, P, 2019) |
"Colon cancer is a major cause of death around the world." | ( Ali, ANM; Ghasemian, A; Kareem, SM, 2020) |
"Colon cancer is the 4th most common cancer causing death in both male and female equally, mainly caused due to the improper diet plans, consumption of the red meat and lack of exercise." | ( Karthika, C; Sureshkumar, R, 2019) |
"Colon cancer is one of the leading cause of cancer deaths that is severely threatening human health." | ( Hui, T; Xu, C; Ye, K, 2019) |
"Globally, colon cancer is a predominant cause of increased morbidity and mortality annually; therefore, in addition to traditional treatments, new protocols are under continuous investigation." | ( Alnaggar, M; Chen, Y; Xiao, H, 2019) |
"Background: Colon cancer is aggressive and it causes 0." | ( Bakshi, HA; Changez, M; Hakkim, FL; Kayalvizhi, N; Krishnan, M; Ramesh Kumar, N; Revathi, S; Sangilimuthu, AY; Tambuwala, MM, 2019) |
"Colon cancer is a member of malignant tumors in the digestive system." | ( Chen, J; Fan, W; Feng, Y; Feng, Z; Guo, M; Guo, S; Jia, H; Liu, S; Wang, Z; Wu, Q; Zhang, C; Zhang, Y; Zhao, T; Zhou, Q, 2020) |
"Colon cancer is one of the most life-threatening cancers with high incidence and mortality rates." | ( Pham, DT; Saelim, N; Tiyaboonchai, W, 2020) |
"Colon cancer is the second most common deadliest malignancy in the world and better understanding of its underlying mechanisms is needed to improve clinical management." | ( Chandimali, N; Kong, LZ; Kwon, T; Lee, DS; Liu, R; Sun, HN; Zhen, X, 2019) |
"Advanced colon cancer is extremely difficult to cure, underscoring the need to develop novel therapeutic agents." | ( Epifano, F; Fiorito, S; Genovese, S; Majumdar, APN; Nangia-Makker, P; Preziuso, F; Slater, J, 2020) |
"Colon cancer is one of the most common malignancies." | ( Cui, MZ; Deng, Y; He, BC; Hu, Y; Huang, J; Li, FS; Li, L; Li, PP; Shu, DZ; Zeng, JR, 2020) |
"Colon cancer is one of the leading causes of cancer-related deaths and its five-year survival rate remains low in locally advanced or metastatic stages of colon cancer." | ( Chen, CH; Cho, EC; Hsieh, YC; Liu, YR; Yang, PM, 2020) |
"Colon cancer is considered to be the third most common cancer worldwide." | ( Abd El-Hady El-Safti, FE; Abdel-Rahman, SA; Badr El-Kholy, W; Mohey Issa, N, 2021) |
"However, colon cancer is difficult to treat due to its resistance to TRAIL." | ( Kim, B; Lee, KY; Park, B; Seo, JH, 2020) |
"Colon cancer is one of the most common and has the highest mortality rate in the world." | ( Chen, YH; Huang, XL; Huang, ZM; Li, YL; Lin, XR; Wu, XX, 2020) |
"Colon cancer is one of the most common malignancies and the fourth leading cause of cancer-related mortality in the world." | ( Alikhani, MY; Hakimi Alni, R; Kosari, F; Moradi, A; Taheri, M, 2020) |
"Colon cancer is a serious malignant type of cancer in the world." | ( Asemi, Z; Karimian, A; Majidina, M; Mir, SM; Safa, A; Shi, X; Valizadeh, A; Yosefi, B, 2020) |
"Colon cancer is characterized by a shift in sphingolipid balance that favors the production and accumulation of oncogenic species such as sphingosine 1-phosphate (S1P)." | ( Grbčić, P; Sedić, M, 2020) |
"Colon cancer is one of the most common cancers with high mortality in humans." | ( Chen, M; Fang, L; Feng, HT; Lee, MH; Tang, BZ; Xiong, F; Zou, S, 2020) |
"Colon cancer is a common and deadly human digestive tract malignant tumor with poor prognosis." | ( Cao, G; Gao, C; Gao, G; Jiang, X; Wang, W; Zhao, J, 2021) |
"Colon cancer is one of the most prevalent diseases, and traditional chemotherapy has not been proven beneficial in its treatment." | ( Deshmukh, R, 2020) |
"Colon cancer is a highly anabolic entity with upregulation of glycolysis, glutaminolysis, and de novo synthesis of fatty acids, which also induces a hypercatabolic state in the patient." | ( Dueñas-Gonzalez, A; Schcolnik-Cabrera, A, 2021) |
"The risk of colon cancer is greater in patients with inflammatory bowel disease (IBD) than in the general population." | ( Castaño-García, A; de Francisco, R; González-Bernardo, O; Jiménez-Beltrán, V; Pérez-Martínez, I; Riestra, S; Rollé, V; Suárez, A; Suárez, P; Vivas, S, 2021) |
"Colon cancer is the commonest cancer worldwide." | ( Bahr, HI; El-Sherbiny, M; Elbahaie, AM; Elmahdi, HS; Gabr, AM; Ibrahiem, AT; Soliman, N; Youssef, AM; Zaitone, SA, 2021) |
"Colon cancer is the third most deadly and one of the most diagnosed diseases in the world." | ( Muralikrishna, KS; Nelson, VK; Pullaiah, CP; Sahoo, NK; Sahu, M; Sudhan, HH, 2020) |
"Colon cancer is one of the most common causes of deaths by cancer worldwide." | ( Alkhuriji, AF; Alnafjan, AA; Alobaid, H; Alomar, SY; Alsaiari, SG; El-Khadragy, MF, 2021) |
"Colon cancer is a common and leading cause of death and malignancy worldwide." | ( Huang, L; Kong, W; Li, P; Zhu, J; Zhu, S, 2021) |
"Colon cancer is one of the most familiar malignancies worldwide, with high morbidity and high mortality." | ( Gao, D; Guo, W; Qu, Y; Wang, J; Xiong, L; Yang, Y; Zhang, Y, 2021) |
"Colon cancer is the fourth leading cause of cancer deaths around the world." | ( Fuel, M; Martínez, R; Melguizo, C; Mesas, C; Porres, JM; Prados, J, 2022) |
"Colon cancer is a life-threatening disease all over the world and is linked to constant oxidative stress and inflammation." | ( Afzal, SM; Ali, N; Islam, J; Rashid, S; Shree, A; Sultana, S; Vafa, A, 2021) |
"Colon cancer is a top lethal cancer in man and women worldwide and drug resistance is the major cause of cancer-related death." | ( Gu, W; Hu, Y; Ji, X; Jiang, T; Li, F; Li, L; Niu, X; Pang, L; Qi, Y; Wang, C; Xu, Z; Zhang, K; Zhao, W; Zheng, X; Zhu, X; Zou, H, 2021) |
"Colon cancer is one of the leading causes of cancer death worldwide." | ( El-Nezami, H; Lee, JC; Lo, EKK; Turner, PC, 2021) |
"Colon cancer is an adenocarcinoma, which subsequently develops into malignant tumors, if not treated properly." | ( Albalawi, R; Khan, FA; Pottoo, FH, 2022) |
"Also, colon cancer is initiated by aberrant Wnt signaling in ISCs known to express high levels of LGR5." | ( Alharbi, SA; Ovchinnikov, DA; Wolvetang, E, 2021) |
"Colon cancer is a malignant condition that affects the lower gastrointestinal tract and has unfavorable prognosis." | ( Ali, DA; Arab, HH; Ashour, AM; Kabel, AM, 2021) |
"Colon cancer is one of the leading causes of cancer-related deaths worldwide." | ( Abdelaziz, LA; Gertallah, LM; Harb, OA; Taha, HF, 2022) |
"Colon cancers are among the top three causes of cancer-related deaths." | ( Coskun, D; Dik, B; Er, A, 2022) |
"Colon cancer is characterised by the persistent change in bowel habits due to the formation of polyps (cancerous) in the inner lining of the colon." | ( Dua, K; Gowthamarajan, K; Gulati, M; Gupta, G; Kaur, J; Kumar Chellappan, D; Kumar, B; Pandey, NK; Singh, SK; Vishwas, S, 2021) |
"Colon cancer is accompanied by a decrease of epithelial barrier properties, which are determined by tight junction (TJ) proteins between adjacent epithelial cells." | ( Amasheh, S; Bekusova, V; Droessler, L; Markov, AG, 2021) |
"Colon cancer is one of the most common malignant tumors in the digestive system." | ( Dang, C; Guo, J; Jia, H; Li, J; Li, M; Li, R; Li, X; Li, Y; Liu, Z; Wang, S; Zhang, Y; Zhao, T; Zhu, G, 2021) |
"Colon cancer is one of the most common cancers, currently treated with traditional chemotherapies or alternative therapies." | ( Arena, A; Bassetti, E; Benedetti, R; Caiazzo, R; Cirone, M; D'Orazi, G; Gilardini Montani, MS; Maretto, M; Romeo, MA, 2021) |
"Colon cancer is one of the most commonly diagnosed malignancies, which begins as a polyp and grows to become cancer." | ( Fakhri, KU; Imtiyaz, K; Nafees, S; Rizvi, MMA; Uroog, L; Zeya, B, 2022) |
"Colon cancer is a most common malignant cancer in digestive system, and it is prone to develop resistance to the commonly used chemotherapy drugs, leading to local recurrence and metastasis." | ( Bai, S; Cheng, Y; Ji, Q; Jiang, C; Liu, D; Liu, M; Mei, Q; Sun, Y; Ye, W; Zhang, B; Zhou, S, 2021) |
"Colon cancer is one of the leading causes of death in the world." | ( Bronikowska, J; Czuba, ZP; Janeczko, T; Kostrzewa-Susłow, E; Kłósek, M, 2022) |
"Colon cancer is one of the most important causes of death in the entire world." | ( Collin, A; Kohan, R; Picotto, G; Tolosa de Talamoni, N, 2022) |
"Colon cancer is one of the most common cancers." | ( Armağan, I; Bayram, D; Özgöçmen, M; Semerci Sevimli, T; Sevimli, M, 2022) |
"Colon cancer is emerging as one of the most prevalent cancers globally." | ( Chen, L; Duan, H; Gao, Z; Hou, Y; Huang, W; Jin, J; Jin, M; Liu, C, 2022) |
"Colon cancer is a gastrointestinal malignancy that is one of the leading causes of tumor-associated deaths." | ( Liu, ZJ; Lou, J; Lv, JX; Zhang, YP, 2022) |
"Colon cancer is a common cause of death in the world, and its main cause of therapy failure is chemoresistance." | ( Deng, YY; Fu, J; Pan, SL; Qin, XJ; Zhang, YH; Zhang, ZJ, 2022) |
"Colon cancer is the fourth leading cause of death in the world." | ( Abdolazimi, H; Fallah, A; Nazari Robati, F; Talaei, B; Tezerji, S, 2022) |
"Colon cancer is one of the most leading death-causing cancers in the world." | ( Cao, W; Hong, H; Huang, C; Liu, C; Wang, Q, 2022) |
"Colon cancer is a gastrointestinal malignancy with high incidence and poor prognosis." | ( Fu, X; Lin, L; Liu, Z; Sui, H; Wang, Y; Xia, W; Zhang, Y, 2022) |
"Colon cancer is the third most predominant cancer caused by genetic, environmental and nutritional factors." | ( Adhikary, S; Banerjee, A; Dharshnaa, V; Duttaroy, AK; Esmeeta, A; Pathak, S; Swarnamughi, P; Ummul Maqsummiya, Z, 2022) |
"Drug resistance in colon cancer is gradually affecting the treatment." | ( Chen, X; Guo, M; Li, B; Lin, C; Qiu, H, 2022) |
"Colon cancer is the second most frequently diagnosed cancer in women in Norway, where incidence rates of colon cancer increased 3-fold between 1955 and 2014, for unknown reasons." | ( Borch, KB; Laaksonen, MA; Licaj, I; Lukic, M; Rylander, C; Weiderpass, E, 2023) |
"Colon cancer is a common malignant tumor of the digestive tract." | ( Shi, C; Wang, S; Zhang, Z; Zhu, Q, 2023) |
"Colon cancer is the third most common cancer worldwide, and the second in mortality rate." | ( Agarwal, S; Gor, R; Karri, U; Madhavan, T; Pachaiappan, R; Ramalingam, S; Saha, L; Sohani, A, 2022) |
"Most deaths from colon cancer are due to metastasis." | ( Bae, KB; Baik, H; Hur, DY; Kang, MS; Kim, SH; Song, SE, 2022) |
"Colon cancer is a widespread life-threatening malignancy with complex and multifactorial etiology." | ( Cui, Z; Li, P; Li, W; Liu, K; Min, L; Teng, S; Wang, Y; Wu, J; Xu, J; Yang, Y; Zhang, N; Zhang, S; Zhao, M, 2023) |
"Colon cancer is a widespread life-threatening malignancy with complex and multifactorial etiology." | ( Cui, Z; Li, P; Li, W; Liu, K; Min, L; Teng, S; Wang, Y; Wu, J; Xu, J; Yang, Y; Zhang, N; Zhang, S; Zhao, M, 2023) |
"Colon cancer is a widespread life-threatening malignancy with complex and multifactorial etiology." | ( Cui, Z; Li, P; Li, W; Liu, K; Min, L; Teng, S; Wang, Y; Wu, J; Xu, J; Yang, Y; Zhang, N; Zhang, S; Zhao, M, 2023) |
"Colon cancer is a major malignant neoplasm with a low survival rate for late-stage patients." | ( Chang, CH; Cho, EC; Hsieh, YC; Lee, CH; Liu, HH; Liu, YR; Zheng, JH, 2022) |
"Colon cancer is a major malignant neoplasm with a low survival rate for late-stage patients." | ( Chang, CH; Cho, EC; Hsieh, YC; Lee, CH; Liu, HH; Liu, YR; Zheng, JH, 2022) |
"Colon cancer is a major malignant neoplasm with a low survival rate for late-stage patients." | ( Chang, CH; Cho, EC; Hsieh, YC; Lee, CH; Liu, HH; Liu, YR; Zheng, JH, 2022) |
"Colon cancer is a relatively common malignant tumor of the digestive tract." | ( Fu, X; Li, H; Li, M; Li, T; Niu, Y; Xia, W, 2023) |
"Colon cancer is a type of cancer that begins in the large intestine." | ( Chen, H; Li, Y; Tian, M, 2023) |
"Colon cancer is the second most common cancer in women and the fourth most common cancer worldwide." | ( Hafuth, S; Randhawa, S, 2022) |
"Colon cancer is a great threat to human health." | ( Tong, Q; Wu, Z, 2024) |
"Colon cancer is a significant global health issue, and its primary treatment, chemotherapy, is limited by toxicity and drug resistance." | ( Alsadooni, JFK; Barzegar, A; Feizi, MAH; Haghi, M, 2023) |
"Accurate staging of colon cancer is imperative in directing treatment and prognostication." | ( Gao, Y; Gauci, CM; Kim, TJ; Perera, DS, 2023) |
"Colon cancer is emerging as one of the most common cancers worldwide, ranking in the top three in morbidity and mortality." | ( Chen, S; He, JN; Liu, XQ; Nie, ZQ; Yang, CT; Yang, JM; Zhang, J; Zhao, Y; Zhu, FD, 2023) |
"Colon cancer is a common and deadly malignancy of the gastrointestinal tract." | ( Ding, C; Gao, H; Han, F; Lee, IS; Lee, KY; Li, C; Li, W; Liang, Q; Tang, K; Xiao, Y; Xiong, F, 2023) |
Excerpt | Reference |
"The treatment of rectal and colonic cancer with bony metastases, is disappointing as the disease is always fatal within a relatively short period, usually less than one year after the diagnosis of the bone involvement." | ( Cayla, J; Forest, M; Heisbourg, A; Meary, R; Rondier, J, 1975) |
"Twenty patients with advanced colon cancer were treated with a combination of low-dose weekly cyclophosphamide, vincristine, and methotrexate (COM) after demonstrated progression of disease with 5-fluorouracil (5-FU)." | ( Desai, SA; DeWys, WD; Taylor, SG, 1978) |
"For adjuvant therapy of colon cancer having positive nodes (Dukes C), internal radiation therapy of the liver is best done with Phosphorus-32 Colloid passed through the circulation of the gut to be effectively and homogeneously trapped by the Kupffer cells of the liver." | ( Grady, ED, 1979) |
"The therapy of cancer of the colon still remains unsatisfactory: the rate of remissions could be increased, but survival remains unaltered." | ( Hartmann, D; Obrecht, JP, 1978) |
"CAI pretreatment of HT-29 human colon cancer and 5R ras-transfected rat embryo fibroblast cells inhibits the formation and growth of experimental pulmonary metastases in nude mice." | ( Kohn, EC; Liotta, LA; Sandeen, MA, 1992) |
"Pretreatment of human colon cancer LoVo-H cells and human breast cancer ZR-75 1A cells with low doses of verapamil, a Ca2+ channel blocker, for 48 h has a slight growth stimulatory effect and substantially increases cell sensitivity to lymphokine-activated killer (LAK) mediated cytotoxicity in the standard 51Cr release assay." | ( Bianco, AR; Celio, L; Correale, P; Genua, G; Montagnani, S; Tagliaferri, P, 1991) |
"Because many patients with colon cancer will suffer a relapse we recommend that they be offered the opportunity to participate in clinical trials of adjuvant therapy." | ( Eisenhauer, E; Erlichman, C; Germond, C; Kerr, I; Levine, M; Lofters, W; Maroun, J; Rayner, HL; Skillings, JR; Yoshida, S, 1991) |
"MAWI colonic cancer cells respond to sequential treatment in vitro with carboxypeptidase G2 and trimetrexate by a delay in cell growth as measured by cell numbers, but an increase in incorporation of 75-Se-selenomethionine per cell." | ( Bagshawe, KD; Bradshaw, T; Mellor, B; Melton, RG; Pedley, RB; Searle, F; Sherwood, RF, 1990) |
"Nude mice bearing subcutaneous human colon cancer xenografts (LS174T) were treated with 120 microCi of yttrium 90-labeled anti-carcinoembryonic antigen monoclonal antibodies (specific therapy), 120 microCi of 90Y-labeled anti-melanoma monoclonal antibodies (nonspecific therapy), or phosphate-buffered saline solution (no treatment control)." | ( Beatty, BG; Beatty, JD; Buras, RR; Harris, JB; Hill, LR; Wanek, PM; Williams, LE, 1990) |
"In 14 gastric cancer and 15 colonic cancer cases, to which UFT 400 mg/day and OK-432 2KE 2/W were administered orally and intra-muscularly for 2 weeks preoperatively until surgical treatment, intratumor 5-fluorouracil (5-FU) concentration was measured and compared with that of patients who given UFT 400 mg/day orally for 2 weeks (15 gastric cancer and 15 colonic cancer cases)." | ( Hosoi, H; Kitagawa, M; Sinmyo, K; Susaki, H; Suwa, H; Yamaguchi, K, 1989) |
"Patients (1,256 with colon cancer, 1,221 with rectal cancer) were divided into the treatment group (group A) and the control group (surgical resection only, group B)." | ( Abe, O; Hattori, T; Inokuchi, K; Kikuchi, K; Kodaira, S; Komi, N; Kondo, T; Ogawa, N; Taguchi, T; Uchino, J, 1989) |
"Mucin from xenografts of LS174T human colon cancer cells was treated with anhydrous HF for 1 h at 0 degree C to give a product (HFA) with over 80% of the glucosamine and hexose removed, but retaining some galactosamine, and for 3 h at room temperature to give a product (HFB) devoid of carbohydrate." | ( Byrd, JC; Erickson, R; Itzkowitz, SH; Kim, YS; Kuan, SF; Lamport, DT; Siddiqui, B, 1989) |
"Nude mice bearing xenografts of colon cancer CX1 or X56 were treated for 14-25 days subcutaneously with saline, pentagastrin (0." | ( Smith, JP; Solomon, TE, 1988) |
"Twenty patients with colon cancer metastatic to the liver underwent successful hepatic resection and adjuvant perioperative therapy that included hepatic arterial mitomycin C and floxuridine (FUDR)." | ( Ames, FC; Boddie, AW; Charnsangavej, C; Claghorn, LJ; Cleary, KR; Mavligit, GM; McBride, CM; Patt, YZ, 1987) |
"Twenty-one patients with inoperable colon cancer in the pelvis were treated with intra-arterial 5-fluorouracil (5-FU) and mitomycin C, given bilaterally into the internal iliac arteries." | ( Chuang, VP; Claghorn, L; Mavligit, G; Patt, YZ; Peters, RE; Wallace, S, 1985) |
"Thirty-five patients with metastatic colon cancer received hepatic arterial FUDR administered with implanted infusion pumps." | ( Hohn, DC; Lewis, BJ; Price, DC; Stagg, RJ, 1985) |
"We treated 45 patients with advanced colon cancer with HDFA and 5-FU for 5 consecutive days." | ( Astone, A; Barone, C; Cassano, A; Cavallaro, A; Garufi, C; Grieco, A; Netri, G; Noviello, MR; Ricevuto, E; Rossi, S, 1987) |
"Although previous in vitro reports on colon cancer cell lines have suggested that sodium butyrate might have a role to play as a chemotherapeutic "differentiating agent," the results of this in vivo study indicate that sodium butyrate treatment enhanced the development of colonic neoplasia and was associated with increased fecal butyric acid concentrations." | ( Freeman, HJ, 1986) |
"Twenty patients with metastatic colon cancer without prior chemotherapy received 2 g/m2 of 5-fluorouracil (5-FU) infused over 24 h for 5 days preceded by allopurinol 900 mg orally for 1 week and then continued during, and for 1 week after the infusion was completed." | ( Ahmann, FR; Garewal, H; Greenberg, BR, 1986) |
"An experimental model of colonic cancer can be obtained in rodents by administration of 1-2 Dimethylhydrazine." | ( Delapierre, F; Halkin, E; Laumonier, R; Roussel, F, 1985) |
"Retreatment of patients with colon cancer and liver metastases by hepatic arterial infusion of fluorodeoxyuridine and mitomycin C can result in significant prolongation of survival in patients with response to this treatment." | ( Chuang, VP; Mavligit, G; Patt, YZ; Peters, RE; Wallace, S, 1983) |
"Throughout the experiment, 50 colon cancers developed in 16 DMH-treated mice (mean, 3." | ( Diekema, KA; King, WW; Kingsnorth, AN; Malt, RA; McCann, PP; Ross, JS, 1983) |
"Two cohorts of rats, 240 with colon cancer and 150 controls, were assessed clinically and immunologically for their response to tumour and its management which was either by surgical excision alone or by surgical excision combined with either adjuvant chemotherapy or immunotherapy." | ( House, AK; Maley, MA, 1983) |
"One of the responding patients with colon cancer and two with breast cancer had failed to respond to prior therapy with 5-FU; one of the responding patients with breast cancer had previously received an inadequate trial of a similar regimen." | ( Ervin, TJ; Kufe, DW; Meshad, MW; Weiss, GR, 1982) |
"The radical treatment of colonic cancer results in a gradual normalization of nitrogen-protein metabolism." | ( Buttaev, RM; Fedotov, IL; Gegenava, AP, 1980) |
"At the current time, patients with colon cancer of Dukes stage C should be offered adjuvant chemotherapy with 5-FU/levamisole outside of clinical studies." | ( Herrmann, R; Rochlitz, CF, 1995) |
"Since treatment of colonic cancer remains difficult because of the lack of effective chemotherapeutic agents, it is important to continue to search for cellular functions that can be disrupted by chemotherapeutic drugs and inhibit the development or progression of this disease." | ( Magnuson, BA; Moyana, TN; Raju, RV; Sharma, RK, 1995) |
"Chloride efflux from colon cancer cells is stimulated by cyclic AMP and vaso-active intestinal peptide (VIP), and can be inhibited by pretreatment of the cells with phorbol myristate acetate, which downregulates the cAMP-regulated chloride efflux mechanism." | ( Pålsgård, E; Roomans, GM; von Euler, A; von Steyern, CV, 1993) |
"Recurrence of gastric cancer or colon cancer was observed in some patients who received 5-fluorouracil (5-FU) high-dose continuous Methotrexate (MTX)-Leucovorin (LV) therapy (FML therapy) previously." | ( Fujihara, T; Inokuchi, T; Kawano, K; Kimoto, K; Mori, F; Tamura, Y; Yoshioka, Y, 1994) |
"A 47-year-old man with ascending colon cancer with multiple liver metastases and bone metastasis (VII thoracic vertebra) showed a remarkable response to the combination therapy of tegafur and cisplatin." | ( Arima, S; Futami, K; Hara, F; Harada, Y; Inada, S; Kotoh, T; Nishida, T; Tateishi, S; Yamasaki, K, 1995) |
"A recurrence of colon cancer developed in the left lower lung 16 months after surgery, and 5'-DFUR was administered at a dose of 1,600 mg/body/day." | ( Fujimoto, T; Iihara, K; Kitada, M; Murotani, M; Okumura, Y; Shibata, T; Takada, T; Takami, M; Tsukahara, Y; Watanabe, T, 1995) |
"For Dukes' C colon cancer, postoperative adjuvant chemotherapy with a combination of fluorouracil and levamisole is now recommended as standard therapy." | ( Ilson, DH; Kelsen, DP, 1994) |
"Thirty-nine patients with gastric or colonic cancer were given preoperative chemotherapy with UFT (an admixture of tegafur and uracil)." | ( Arizono, S; Kajiura, N; Konishi, T; Kubota, K; Makuuchi, M; Nakao, K; Oka, T; Teruya, M; Tsushima, H, 1994) |
"Following the diagnosis of colon cancer (Duke's classification D), a chemotherapy regimen of 5-FU and levamisole was started." | ( Israel, MK; Scarfe, MA, 1994) |
"Human colon cancer (HT29) cell survival was decreased by almost 1 log when treated with 500 microM temozolomide prior to 150 microM BCNU." | ( Dolan, ME; Mitchell, RB, 1993) |
"Treatment of human colon cancer cell lines, LS 174T, COLO 205, and SW620, with sodium butyrate and 8-Cl-cAMP or tyrphostins AG-30 and AG-34, significantly attenuated TPK activity concomitantly with an increase in the activity of alkaline phosphatase, an enzymatic marker of intestinal cell differentiation." | ( Kim, YS; Lamprecht, SA; Niv, Y; Polak-Charcon, S; Schwartz, B, 1995) |
"JAK3 mRNA was neither detected in colon cancer cells nor did IL-4 treatment cause phosphorylation of JAK3." | ( Murata, T; Noguchi, PD; Puri, RK, 1995) |
"The intrinsic resistance of human colon cancer to multiple anticancer drugs precludes effective therapy of disseminated disease with available chemotherapeutic regimens." | ( Gravitt, KR; Gupta, KP; O'Brian, CA; Ward, NE, 1995) |
"Projected charges or chemotherapy for colon cancer (5-FU infusion vs." | ( Anderson, NR; Lokich, JJ; Moore, CL, 1996) |
"In another MMR-proficient colon cancer cell line, SW480, cell death occurred five days after MNNG treatment." | ( Boland, CR; Carethers, JM; Chauhan, DP; Hawn, MT; Koi, M; Luce, MC; Marra, G, 1996) |
"Other colon cancer cell lines were examined for the extent of cell death following treatment with TPA/butyrate." | ( Eastman, A; McBain, JA; Mueller, GC; Pettit, GR; Simmons, DL, 1996) |
"In patients with stage III colon cancer, adjuvant chemotherapy with fluorouracil and levamisole has been shown to produce a 40 percent reduction in the recurrence rate at a median follow-up of 6." | ( Ratkin, GA, 1997) |
"The incidence of exophytic or invasive colon cancer and tumor multiplicity were similar in all treatment groups, although the incidence of exophytic neoplasms was higher with 2." | ( Aliaga, C; Braley, J; Pittman, B; Reinhardt, J; Rivenson, A; Weisburger, JH; Zang, E, 1998) |
"Two cases of liver metastasis from colon cancer were treated by percutaneous ethanol (PEI) and acetic acid (PAI) injection for the recurrent lesion after surgery." | ( Iguchi, Y; Sato, K; Shibata, N; Takesue, M; Tsunoda, T; Yamamoto, S, 1998) |
"A group of 205 colon cancer patients (104 in the 5FU arm and 101 in the 5FU + IFNapha-2a arm) were included in the final intention-to-treat analysis." | ( Bernardo, G; Bruni, G; Colucci, G; Danova, M; Dastoli, G; Della Vittoria Scarpati, M; Di Lauro, L; Filippelli, G; Gebbia, N; Leonardi, V; Lo Russo, V; Meli, M; Palmeri, S; Palmieri, G; Piazzi, M; Rausa, L; Russo, A; Spada, S, 1998) |
"SW1116 colon cancer cells were seeded onto Matrigel-coated Boyden chambers and treated with unsupplemented media or media containing 10 mM acetate, propionate, or butyrate." | ( Basson, MD; Emenaker, NJ, 1998) |
"Treatment of two human colon cancer cell lines (HT-29 and WiDr) with 5-FU + gamma-IFN resulted in an increase of CEA expression higher than that obtainable with both agents alone, although no synergistic effects were obtained." | ( Aquino, A; Bonmassar, E; De Filippi, R; De Vecchis, L; Giuliani, A; Graziani, G; Greiner, JW; Masci, G; Prete, SP; Turriziani, M, 1998) |
"Nineteen patients (16 with colon cancer and 3 with breast cancer) who were treated with systemic 5-FU with complaints of tearing were studied retrospectively." | ( Fezza, JP; Klippenstein, KA; Wesley, RE, 1999) |
"Results from experiments performed on colon cancer xenografts also show an association between PARP cleavage and response to treatment with TPT or CPT-11." | ( Berger, NA; Whitacre, CM; Willson, JK; Zborowska, E, 1999) |
"Following treatment of three colon cancer cell lines, HCT116, SW480, and VACO-8, for 48 h with 0." | ( Belfi, CA; Berger, NA; Berger, SJ; Chatterjee, S; Gosky, DM, 1999) |
"The exposure of human colon cancer cells HT-29 to 1,25-dihydroxyvitamin D3 or its analog, 1alpha, 25-dihydroxy-16-ene-23yne-26,27-hexafluoro-19-nor-choleca lci ferol (Ro 25-6760), at the 10(-6) M concentration resulted in significant growth inhibition with induction of the apoptotic process after three days of treatment detected by TUNEL assay and agarose gel electrophoresis of DNA." | ( Bogrash, E; Evans, SR; Shchepotin, EB; Shchepotin, IB; Soldatenkov, V, 1999) |
"Patients with Dukes' B colon cancer benefit from adjuvant chemotherapy and should be presented with this treatment option." | ( Atkins, JN; Bear, HD; Jones, J; Mamounas, E; Rockette, H; Song, K; Wieand, S; Wolmark, N, 1999) |
"At present, studies in B2 colon cancer designed with a no-treatment control arm should be considered appropriate." | ( , 1999) |
"We examined whether patients with colon cancer undergoing surgery with or without adjuvant chemotherapy change the internal standards on which they base their quality-of-life (QL) estimation, and, if they do so, whether this reframing alters interpretation of QL findings." | ( Bernhard, J; Herrmann, R; Hürny, C; Laffer, U; Maibach, R, 1999) |
"Patients with colon cancer substantially reframe their perception in estimating QL both under radical resection and under adjuvant chemotherapy or observation." | ( Bernhard, J; Herrmann, R; Hürny, C; Laffer, U; Maibach, R, 1999) |
"The present treatment of colon cancer is based on 5-fluorouracil (5-FU)." | ( An, Z; Han, Q; Hoffman, RM; Rashidi, B; Sasson, A; Sun, FX; Sun, X; Tan, X; Tan, Y; Wang, X; Xu, M, 1999) |
"In both types of colon cancer cells investigated, 10(-8) M 1alpha,25-(OH)2D3 reduced basal cell proliferation by about 50%, and prevented any rise in proliferation when colon cancer cells were treated with 25 ng/ml EGF: this can be explained by a marked inhibitory effect of 1alpha,25-(OH)2D3 on EGFR mRNA and protein expression." | ( Cross, HS; Ellinger, A; Hofer, H; Peterlik, M; Tong, WM, 1999) |
"Mice bearing human colon cancer were treated with a combination of 4." | ( Aburano, T; Hiramatsu, T; Kinuya, S; Konishi, S; Michigishi, T; Shuke, N; Takayama, T; Tega, H; Tonami, N; Watanabe, N; Yokoyama, K, 1999) |
"Caco2 and HCT116 colon cancer cells were treated with 2 microM PYY for 24 hours." | ( Cole, M; Kim, F; Kling, K; McFadden, D, 1999) |
"Sixty-two patients with 73 colon cancers who were radiographically overlooked were eventually confirmed and treated." | ( Fujisawa, H, 1999) |
"Human colon cancers have a high frequency of p53 mutations, and cancer cells expressing mutant p53 tend to be resistant to current chemo- and radiation therapy." | ( Huang, L; Pardee, AB, 1999) |
"GW-39 human colonic cancer xenografts for therapy studies." | ( Blumenthal, RD; Goldenberg, DM; Lew, W; Osorio, L; Reising, A; Soyne, D; Ying, Z, 2000) |
"Thirty-four patients with metastatic colon cancer were treated with 5 fluorouracil and folinic acid." | ( Giovannini, M; Reggio, H; Sauvan, R; Seigner, C, 1995) |
"Five hundred patients with Dukes' C colon cancer were randomly assigned to adjuvant treatment for one year with 5-fluorouracil (450 mg/m2 i." | ( Bleeker, WA; Hermans, J; Mulder, NH; Otter, R; Plukker, JT, 2000) |
"Mice bearing human colon cancer xenografts were administered 2." | ( Hiramatsu, T; Kawashima, A; Kinuya, S; Konishi, S; Michigishi, T; Shuke, N; Takayama, T; Tonami, N; Watanabe, N; Yokoyama, K, 2000) |
"Treatment of four human colon cancer cell lines with iso-effective concentrations of this agent resulted in depletion of c-raf-1 and akt and inhibition of signal transduction." | ( Banerji, U; Clarke, PA; Hostein, I; Judson, I; Maloney, A; Stefano, FD; Walton, M; Workman, P, 2000) |
"We encountered a case of unresectable colon cancer that disappeared following pharmacokinetic modulating chemotherapy (PMC)." | ( Asahara, T; Nakahara, H; Nakahara, M; Okajima, M; Yano, M, 2000) |
"An experimental rat model of induced colon cancer treated for 30 days with bosentan, a mixed antagonist of both ET receptors, confirmed the morphological changes observed during the tumor vascularization." | ( Bosman, FT; Egidy, G; Jeannin, JF; Juillerat-Jeanneret, L; Korth, P; Pinet, F, 2000) |
"A total of 18 patients (13: colon cancer, 5: gastric cancer) with multiple liver metastases (H3) underwent hepatic arterial infusion chemotherapy (HAI) using an implanted arterial port with portable syringe pumps in our outpatient clinic." | ( Fukunaga, M; Goda, F; Maeba, T; Maeta, H; Mihara, T; Mori, S; Ohkawa, M; Okada, H; Okano, K; Senda, S; Uchida, Y; Usuki, H; Wakabayashi, H, 2000) |
"Treatment of HCT116 human colon cancer cells with the specific mitogen-activated protein kinase kinase, U0126 (5-50 microM) resulted in a time- and dose-dependent inhibition of ERK1/2 phosphorylation, and induction of apoptosis." | ( Ahnen, DJ; Driggers, LJ; Goldberg, RJ; Ray, EC; Rice, PL, 2001) |
"Synchronized HCT 116 colon cancer cells treated with 100 microM SeMet for 66 h were found to have a transient delay in G2/M phase of the cell cycle at 18 and 24 h after treatment." | ( Chigbrow, M; Nelson, M, 2001) |
"The adjuvant treatment of colon cancer is now accepted as an effective therapy following surgical resection of the primary tumor in patients at high risk for relapse." | ( O'Connell, MJ, 2001) |
"The mainstay of treatment of colon cancer is 5-Fluoruracil (5-FU), which should be combined with folinic acid in case of bolus (2-4 min." | ( Mross, K; Semsek, D, 2001) |
"Therefore, two human colon cancer cell lines, WiDr and Lovo, with a different clonogenic origin, were treated with equitoxic concentrations of 5-FU, AG337, and MTA to determine the induction of DNA damage, cell cycle arrest, downstream protein expression, and cell death." | ( Backus, HH; Jansen, G; Kuiper, CM; Peters, GJ; Pinedo, HM; van Groeningen, CJ; Wouters, D, 2000) |
"Treatment of colon cancer cells with MNNG causes DNA damage with reduced telomeric signals in a p53-dependent manner, but increased cell cycle arrest in S-G(2)/M by both p53-dependent and independent mechanisms." | ( Jaiswal, AS; Multani, AS; Narayan, S; Pathak, S, 2001) |
"Brief incubation of colon cancer cells with low concentrations of either Taxol or vinblastine increased the efficacy of a subsequent treatment with topotecan." | ( Bahadori, HR; Catapano, CV; Green, MR, 2001) |
"Selected elderly patients with colon cancer can receive the same benefit from fluorouracil-based adjuvant therapy as their younger counterparts, without a significant increase in toxic effects." | ( Francini, G; Goldberg, RM; Haller, DG; Jacobson, SD; Labianca, R; Macdonald, JS; Sargent, DJ; Seitz, JF; Shepherd, LE, 2001) |
"Patients with colonic cancer were divided into two group: abdominal lymphatic chemotherapy group and control group." | ( Liu, X; Liu, Y; Ruan, C; Sun, Y; Wang, Q; Wang, S; Wang, Y, 2000) |
"Human colon cancer cells (Caco-2 and HT-29) were treated with deoxycholate or its two structural isomers, 3-beta-12-alpha-dihydroxy-5-beta-cholan-24-oic acid and 3-alpha-12-beta-dihydroxy-5-beta-cholan-24-oic acid." | ( Caspary, WF; Faust, D; Milovic, V; Stein, J; Teller, IC, 2002) |
"Since 1981, 100 colon cancer patients have been treated with combination therapy including surgical resection, chemotherapy, and external plus intraoperative radiotherapy." | ( Devine, RM; Donohue, JH; Gunderson, LL; Haddock, MG; Larson, DR; Nagorney, DM; Nelson, H; O'Connell, MJ; Rubin, J; Taylor, WE, 2002) |
"Next, human HCT-8 and HCT-116 colon cancer cells retrovirally transduced to express a DHFR-herpes simplex virus 1 thymidine kinase (HSV1 TK) fusion protein and treated with the DHFR inhibitor TMTX exhibited increased levels of the DHFR-HSV1 TK fusion protein and an increase in ganciclovir sensitivity by 250-fold." | ( Akhurst, T; Balatoni, J; Banerjee, D; Bertino, JR; Blasberg, R; Bornmann, W; Doubrovin, M; Finn, R; Fong, Y; Gelovani Tjuvajev, J; Iwamoto, M; Larson, S; Malhotra, S; Mayer-Kuckuk, P, 2002) |
"In patients with stage II colon cancer it is still unclear whether adjuvant chemotherapy is effective." | ( Boige, V; Ducreux, M, 2002) |
"Human colon cancer cell lines were treated with the NO donor GTN." | ( Bettaieb, A; Hammann, A; Jeannin, JF; Mignotte, B; Millet, A; Prevotat, L; Renaud, F; Solary, E, 2002) |
"Six unselected human colon cancer cell lines (HT29, HCT15, HCT116, Caco2, SW480 and SW620) were treated with a single 3-h exposure to cisplatin or oxaliplatin at suprapharmacological concentrations, ranging from 50 to 200 microg/ml." | ( Chapusot, C; Chauffert, B; Correia, M; Franco, N; Isambert, N; Lizard-Nacol, S; Sergent, C, 2002) |
"Treatment of the human colon cancer cells Hct116 with SN-38 (an active metabolite of CPT-11) resulted in G2 cell cycle arrest without induction of apoptosis." | ( Commes, T; Motwani, M; Schwartz, GK; She, Y; Sirotnak, FM, 2002) |
"p53 wild- and mutant-type gastric and colon cancer cell lines were treated by 5FU alone, TRAIL alone, and a combination of 5FU and TRAIL, and cell viability after each treatment was determined by MTT assay." | ( Kaminishi, M; Kusada, O; Mochizuki, Y; Shimoyama, S, 2002) |
"CT-26 colon cancer cells were treated with VES in vitro and in an in vivo model of liver metastases." | ( Barnett, KT; Fokum, FD; Malafa, MP, 2002) |
"This is the first study of colon cancer carcinogenesis demonstrating that DHEA treatment can decrease the number of ACF without apparently modifying their malignant potential." | ( Matsuhashi, N; Nagase, H; Nakagama, H; Nakajima, A; Ochiai, M; Omura, M; Osawa, E; Sekihara, H; Ueno, N; Wada, K; Yoshida, S, 2002) |
"Here, the cultured colon cancer cell line HCT-15 that exhibited VIP receptor expression was treated with the VIP hybrid antagonist neurotensin(6-11)VIP(7-28)." | ( Dreznik, Z; Fridkin, M; Gal, R; Gozes, I; Granoth, R; Levy, A, 2002) |
"Adjuvant chemotherapy for colon cancer has been established during the past decade." | ( Dencausse, Y; Fritze, D; Hagmüller, E; Hartung, G; Kopp-Schneider, A; Lindemann, H; Queisser, W; Sturm, J; Wojatschek, C, 2002) |
"Patients with stage III colon cancer after curative en bloc resection were randomized in 3 treatment groups: arm A (5-FU/LEV, weekly, 12 months), arm B (5-FU/FA, days 1-5, every 4 weeks, 12 months) and arm C (like B, 6 months)." | ( Dencausse, Y; Fritze, D; Hagmüller, E; Hartung, G; Kopp-Schneider, A; Lindemann, H; Queisser, W; Sturm, J; Wojatschek, C, 2002) |
"Human colon cancer LoVo cells were treated in both a dose- and time-dependent manner using clinically relevant concentrations of and exposure to 5-FU and/or SN-38." | ( Azzariti, A; Church, SW; Colucci, G; Johnston, PG; Lacalamita, R; Paradiso, A; Tommasi, S; Xu, JM, 2002) |
"In vivo, human colon cancer xenografts were transplanted into BALB/C nude mice and treated with TNP-470 alone and combination with 5-FU." | ( Fan, YF; Huang, ZH; Nie, J, 2002) |
"After curative resection of a stage III colon cancer, adjuvant treatment with 5-FU plus leucovorin is generally well tolerated." | ( Arkenau, HT; Bermann, A; Porschen, R; Rettig, K; Strohmeyer, G, 2003) |
"CT-26 murine colon cancer cells transfected with HSV-tk, alone or in combination with bcl-xL or bfl-1, were either grown in vitro or injected into syngeneic mice, followed by GCV administration." | ( Choi, HY; Jeong, J; Kim, CW; Ko, JK; Kwon, GY; Lee, MJ; Shim, YH; Woo, JK, 2003) |
"HT-29 colon cancer xenografts in paricalcitol-treated nude mice were smaller (1044 mm(3) and 1752 mm(3), difference = 708 mm(3), 95% confidence interval = 311 to 1104 mm(3); P =." | ( Koeffler, HP; Kumagai, T; O'Kelly, J; Said, JW, 2003) |
"We present a case of colon cancer with idiopathic leukopenia who tolerated chemotherapy without worsening of leukopenia." | ( Mehdi, SA; Pervez, H; Potti, A, 2003) |
"The treatment of colon cancer has been aimed by approaches of oral drug administration." | ( Kawashima, Y; Lamprecht, A; Takeuchi, H; Yamamoto, H, 2003) |
"Treatment of human colon cancer cell lines with apoptotic concentrations of sulindac metabolites (sulindac sulfide, sulindac sulfone) induced a dose- and time-dependent inhibition of beta-catenin protein expression." | ( Ahnen, DJ; Beard, KS; Driggers, LJ; Kelloff, J; Kuwada, S; Piazza, G; Rice, PL; Sullivan, H, 2003) |
"Treatment of colon cancer cells with 15S-HETE inhibited cell proliferation and induced apoptosis, which was preceded by an increase in TGF-beta-inducible early gene (TIEG) and a decrease in Bcl-2." | ( Chan, UP; Chen, GG; Lee, JF; Leung, KL; Spelsberg, TC; Subramaniam, M; Wang, SH; Xu, H, 2003) |
"HCT116, HT29, and SW620 colon cancer cells were treated with 17AAG, and extracts were examined by 31P-MRS." | ( Banerji, U; Chung, YL; Griffiths, JR; Jackson, LE; Judson, IR; Leach, MO; Ronen, SM; Stubbs, M; Troy, H; Walton, MI; Workman, P, 2003) |
"Treatment of certain human colon cancer cell lines with the HER-2 inhibitory antibody mAb 4D5 demonstrated a role for HER-2 in mediating proliferation, apoptosis and tumorigenicity." | ( Coffey, RJ; Florell, SR; Gray, PD; Kuang, J; Kuwada, SK; Li, X; Scaife, CL; Wong, RF, 2004) |
"Patients with high-risk resected colon cancer obtain benefit from FU-based therapy across subsets of age, sex, location, T stage, nodal status, and grade." | ( Alberts, SR; Benedetti, J; Cha, SS; Chen, W; Francini, G; Francois Seitz, J; Gill, S; Goldberg, RM; Haller, DG; Heldebrant, MP; Labianca, R; Loprinzi, CL; Sargent, DJ; Shepherd, LE; Thomé, SD, 2004) |
"We subjected HCT116 colon cancer cells to two different 5-FU treatment protocols in an attempt to generate resistant derivatives: one that simulated the clinical bolus regimens using clinically-achievable 5-FU levels, the other that utilized serial passage in the presence of increasing 5-FU concentrations (continuous exposure)." | ( De Angelis, PM; Haug, T; Kravik, KL; Reichelt, WH; Tunheim, SH, 2004) |
"The standard adjuvant treatment of colon cancer is fluorouracil plus leucovorin (FL)." | ( André, T; Boni, C; Bridgewater, J; Clingan, P; de Gramont, A; Hickish, T; Mounedji-Boudiaf, L; Navarro, M; Tabah-Fisch, I; Tabernero, J; Topham, C; Zaninelli, M, 2004) |
"We report a patient with metastatic colon cancer who developed a hypersensitivity reaction to oxaliplatin during the sixth cycle of combination chemotherapy with oxaliplatin, high-dose 5-fluorouracil and leucovorin." | ( Chang, MC; Chang, YF; Hsieh, RK; Huang, MJ; Lim, KH; Lin, HC; Lin, J; Su, YW, 2004) |
"Future studies in adjuvant therapy for colon cancer will explore oxaliplatin and 5-FU with or without antiangiogenesis or anti-epidermal growth factor agents." | ( Andre, T; de Gramont, A, 2004) |
"We prepared a colon cancer-bearing Yoshida sarcoma rat model to examine the dose-response relationship of antitumor activity of intracolonically or orally administered 5-fluorouracil (5-FU; 45, 30, 20, 13, and 8 mg/kg)." | ( Fujimura, A; Goto, T; Kobayashi, E; Tomizawa, N, 2004) |
"Moreover, EP(3) expression in colon cancer cell lines was analysed with or without 5-aza-2'-deoxycytidine (5-aza-dC) treatment." | ( Kawamori, T; Kitamura, T; Maruyama, T; Narumiya, S; Negishi, M; Shoji, Y; Sugimoto, Y; Sugimura, T; Takahashi, M; Wakabayashi, K; Watanabe, K, 2004) |
"Patients with resected colon cancer with tumor adherence or invasion of surrounding structures, or with T3N1 or T3N2 tumors of the ascending or descending colon were randomly assigned to receive fluorouracil and levamisole therapy with or without radiation therapy." | ( Benson, AB; Donohue, JH; Fisher, B; Goldberg, RM; Gunderson, LL; Mailliard, JA; Martenson, JA; Myerson, R; Sargent, DJ; Thomas, CR; Willett, CG, 2004) |
"The protein and mRNA levels in colon cancer cell lines with and without treatments were determined by Western and Northern blot analysis, respectively." | ( Jaiswal, AS; Narayan, S, 2004) |
"When SW620 colon cancer-derived metastatic cells were exposed to nanomolar concentrations of Taxol, colchicine or (Z)-3,5,4'-trimethoxystilbene (R3), huge aneuploid, polynuclear cells survived the treatment." | ( Gossé, F; Raul, F; Schleiffer, R; Schneider, Y; Seiler, N, 2004) |
"For patients with resectable colon cancer, improved identification of LN disease would significantly advance patient care by identifying patients likely to benefit from adjuvant therapy." | ( Bem, J; Bertagnolli, M; Compton, C; Dowell, J; Fleshman, J; Mayer, R; Miedema, B; Niedzwiecki, D; Redston, M; Zinner, M, 2004) |
"We report a case of recurrent colon cancer resistant to 5-FU, whose QOL and PS has been well maintained with low-dose CPT-11/CDDP administered on an outpatient basis for more than 28 months." | ( Fukuhara, A; Kikuchi, S; Murayama, M; Nakamura, E; Nishimoto, Y; Nozaki, H; Shouda, S; Watanabe, Y; Yagyu, T, 2004) |
"To estimate patterns of colon cancer presentation, diagnosis, and treatment according to history of dementia using National Cancer Institute (NCI) Surveillance, Epidemiology, and End-Result (SEER) Medicare data." | ( Gupta, SK; Lamont, EB, 2004) |
"Three human colon cancer cell lines were treated with BB-pol: HT-29, HCT-116, and Caco-2." | ( Ji, GE; Oh, DK; You, HJ, 2004) |
"In human colonic cancer HCT8 cells, the hydrogen peroxide (H(2)O(2))-induced increase in nuclear condensation, the population of sub-G(1) peak, and the number of TUNEL-positive cells were observed in cells pretreated with edible mushroom lectin, an inhibitor of the nuclear transport of GSTpi." | ( Goto, S; Ihara, Y; Kamada, K; Kawai, Y; Kondo, T; Matsuo, T; Nagata, I; Okunaga, T; Osawa, T; Tsuji, K; Uchida, K, 2004) |
"In vitro, human colon cancer cell lines were treated with anti-CEA MAb IgG1, hMN-14 (labetuzumab), to assess direct effects on proliferation, as well as antibody-dependent cellular cytotoxicity (ADCC), and complement-dependent cytotoxicity (CDC)." | ( Blumenthal, RD; Goldenberg, DM; Hansen, HJ; Hayes, MK; Horak, ID; Osorio, L, 2005) |
"Results showed that pretreating colon cancer cells with cigarette smoke extract (CSE) promoted colon cancer growth in the nude mouse xenograft model." | ( Bruce, IC; Cho, CH; Shin, VY; Wong, BC; Wu, WK; Ye, YN, 2005) |
"Quercetin treatment of the SW480 human colon cancer cells was found to result in the decreased expression of three proteins and the increased expression of one protein." | ( Grider, A; Hargrove, JL; Kolli, K; Mouat, MF; Orlando, R, 2005) |
"Pretreatment of HCT116 and RKO colon cancer cells (wild-type p53) or primary human fibroblasts (1043SK) with nutlins for 24 hours followed by incubation with paclitaxel for additional 48 hours did not increase significantly their mitotic index and protected the cells from the cytotoxicity of paclitaxel." | ( Carvajal, D; Heimbrook, DC; Tovar, C; Vassilev, LT; Vu, BT; Yang, H, 2005) |
"Adjuvant chemotherapy for colon cancer has changed significantly during the past 5 years." | ( Vega-Stromberg, T, 2005) |
"Adjuvant chemotherapy for colon cancer and combined chemotherapy and radiation therapy (RT) for rectal cancer increases the proportion of patients cured of their disease." | ( Hobday, TJ, 2005) |
"Treatment of KM12L4a human colon cancer cells with CHIR-258 resulted in a dose-dependent inhibition of vascular endothelial growth factor receptor 1 and PDGFRbeta phosphorylation and reduction of phosphorylated extracellular signal-regulated kinase (ERK) levels, indicating modulation of target receptors and downstream signaling." | ( Aukerman, SL; Garrett, E; Gelb, AB; Harris, A; Heise, C; Lee, SH; Lopes de Menezes, D; Nordahl, L; Samara, E; Vora, J; Ye, H, 2005) |
"WiDr human colon cancer cells treated with IL-15 and/or TGF-alpha induced reduction of nucleus-localized amphoterin and an increase in cytosolic and membranous amphoterin." | ( Kuniyasu, H; Sasahira, T; Sasaki, T, 2005) |
"Patients with curatively resected colon cancer (stages UICC IIb and III) were stratified according to T, N, and participating center and randomized to receive a 12-month treatment using 5-FU + LEV alone or in combination with FA or IFN-alpha." | ( Beger, HG; Kornmann, M; Kron, M; Link, KH; Redenbacher, M; Staib, L, 2005) |
"A panel of nine colon cancer cell lines were characterised for expression of HER 1/EGFR and then treated with gefitinib alone, or IFN alpha alone, or IFN alpha plus gefitinib, following a pre-treatment using vehicle or IFN alpha." | ( Goldstein, D; Qu, XJ; Russell, PJ; Yang, JL, 2005) |
"A human colon cancer cell line (S1) was treated with various doses of oxaliplatin, 5FU, radiation, and combinations thereof." | ( Johnsson, A; Kjellén, E; Kjellström, J, 2005) |
"Moser, a human colon cancer cell line, was treated with bexarotene and rosiglitazone alone or in combination and the effect on growth and differentiation were examined." | ( Bissonnette, RP; Cesario, RM; Lamph, WW; Stone, J; Yen, WC, 2006) |
"The patient, who had unresectable colon cancer metastases to the liver and lung, was referred to us for chemotherapy from an affiliated hospital; he had no cardiac history." | ( Hatakeyama, K; Muneoka, K; Shirai, Y; Wakai, T; Yokoyama, N, 2005) |
"Treatment of colon cancer cells with beta-cyclodextrin significantly reduced not only matrilysin binding to the cell surface but also matrilysin-dependent proteolysis and cell aggregation." | ( Higashi, S; Honke, K; Kioi, M; Miyazaki, K; Tsunezumi, J; Yamamoto, K, 2006) |
"Four human colon cancer cell lines including HCT116 and RKO (wild type p53), HCT116-p53KO (isogenic control of HCT116 cells with p53 knocked out) and Caco-2 (mutant p53) were treated with 0-100 microM of selenomethionine for 24, 48 and 72 h." | ( Boland, CR; Fuerst, F; Goel, A; Hotchkiss, E, 2006) |
"A 72-year-old Latino male with stage IV colon cancer entered into hospice care and was treated for major depressive disorder with mirtazapine." | ( Guardiola, VD; Ladino, M; Paniagua, M, 2006) |
"A subset of patients with colon cancer staged by conventional methods have occult micrometastases and do not receive adjuvant chemotherapy." | ( Filipenko, D; Hwang, H; Phang, PT; Smith, J; Wiseman, KW, 2006) |
"Mortality from colon cancer is significant with an expected 30,350 colon cancer deaths in 2005 with current treatment(s)." | ( Alli, AA; Gower, WR; Vesely, BA; Vesely, DL, 2005) |
"(1) The standard treatment for colon cancer is surgical excision, but without additional treatment nearly 50% of surgically treated patients die from relapse and metastatic disease progression." | ( , 2006) |
"EGCG treatment to colon cancer cells resulted in a strong activation of AMPK and an inhibition of COX-2 expression." | ( Baik, HW; Ha, J; Hwang, JT; Kim, YM; Lee, SK; Park, IJ; Park, OJ, 2007) |
"In stage II colon cancer, treatment strategies are more debated." | ( Afchain, P; André, T; de Gramont, A; Segura, C, 2006) |
"SLN mapping is feasible for colon cancer and can identify a subset of patients who could benefit from adjuvant chemotherapy." | ( Geisinger, KR; Lechner, J; Levine, EA; Shen, P; Thomas, KA; Waters, GS, 2006) |
"HCT116 colon cancer cells were treated with docetaxel, flavopiridol, and 5-FU in several different administrative schedules in vitro, either sequentially or simultaneously." | ( Becerra, CR; Frenkel, EP; Fu, YC; Guo, J; Tripathy, D; Verma, UN; Zhou, AW, 2006) |
"We present a colon cancer patient with the UGT1A1 polymorphism (UGT1A1 *28) as a known high risk for irinotecan, who was treated with a combination of doxifluridine and irinotecan for peritoneal dissemination resulting in stable disease for 2 years without adverse reactions, although the patient initially developed severe adverse effects to the combination of the protracted venous infusion of 5-FU and irinotecan." | ( Hiro, J; Inoue, Y; Kusunoki, M; Miki, C; Nakatani, K; Nobori, T; Ojima, E; Toiyama, Y; Watanabe, H, 2006) |
"Human colon cancer cell lines were treated with the nitric oxide donor glyceryl trinitrate (GTN) before analyzing beta-catenin expression by immunofluorescence, immunoblotting, and immunoprecipitation methods and its transcriptional activity using a luciferase reporter gene driven by a T-cell factor-responsive promotor." | ( Bettaieb, A; Filomenko, R; Jeannin, JF; Prévotat, L; Solary, E, 2006) |
"Two metastatic colonic cancer patients were successfully treated by the combination therapy of UFT plus oral Leucovorin (UFT/LV)." | ( Ando, T; Goto, H; Ina, K; Inagaki, J; Ito, A; Kataoka, T; Kato, H; Nagao, S; Niwa, Y; Ohkita, T, 2006) |
"Human colon cancer Caco-2 cells were treated with either: placebo, IND (0." | ( Chai, J; Huang, RH; Tarnawski, AS, 2006) |
"Treatment of colon cancer cells SW480 with sodium butyrate (NaB), which induces colon cancer cell differentiation, can induce the upregulation of GCIP expression, suggesting that the protein functions as a negative regulator in cell proliferation." | ( Li, D; Li, X; Liu, M; Luo, J; Ma, W; Ning, G; Stafford, LJ, 2007) |
"Human colon cancer HCT-116 and HCT-15 cells cultured in vitro were treated with troglitazone." | ( Luo, HS; Meng, XZ; Ming, M; Yu, HG; Yu, JP; Zhou, YH, 2006) |
"Human colon cancer cell line HCT-15 was treated with DAC and/or CPT-11 both in vitro and in vivo." | ( Enomoto, M; Iida, S; Ishiguro, M; Kato, K; Makino, H; Morita, S; Sugihara, K; Takagi, Y; Uetake, H, 2007) |
"Human colon cancer cell line SW1116 cells were treated with Rottlerin." | ( Chen, ZF; Fang, JY; Lu, R; Sun, DF; Wang, X; Weng, YR, 2006) |
"The X-ACT (Xeloda in Adjuvant Colon Cancer Therapy) trial compared the efficacy and safety of the oral fluoropyrimidine capecitabine with bolus 5-fluorouracil (5-FU)/leucovorin (LV; Mayo Clinic regimen) as adjuvant therapy for stage III colon cancer." | ( Twelves, CJ, 2006) |
"In the human colon cancer cell line SW1116, treatment with the DNA methyltransferase 1 (DNMT1) inhibitor 5-aza-2'-deoxycytidine (5-aza-dC) or the ERK-MAPK inhibitors PD98059 or rottlerin, or transient transfection with the MAP/ERK kinase (MEK)1/2 small interfering RNA down-regulates DNMT1 and proliferating cell nuclear antigen levels." | ( Chen, ZF; Fang, JY; Lu, R; Sun, DF; Tian, XQ; Wang, X, 2007) |
"Patients aged > or = 70 years with colon cancer benefit from chemotherapy, with no major added toxicities compared with a younger population." | ( Fakih, MG; Reddy, N; Yu, J, 2007) |
"Treatment of the human colon cancer cell line, LS174T, with 1-2 mM sodium butyrate stimulated MUC2 mucin production, as determined by histological PAS staining of carbohydrate chains of mucin, and confirmed at the protein and mRNA levels by immunoblotting with anti-MUC2 antibody and real-time RT-PCR, respectively." | ( Abe, T; Hatayama, H; Iwashita, J; Kuwajima, A, 2007) |
"HT-29 and SNU-C4 human colon cancer cell lines were treated with 5-FU and their relative chemoresistance, and Hsp70 were determined." | ( Correa, LP; da Rocha, AB; Grivicich, I; Henriques, JA; Jotz, GP; Regner, A; Schwartsmann, G; Zanoni, C, 2007) |
"Gene expression of 7 colon cancer cell lines was evaluated before and after treatment with the demethylating agent 5-aza-2'-deoxycytidine (5Aza-dC) by oligonucleotide microarray analysis." | ( Kang, HJ; Kim, H; Kim, NK; Koh, KH; Rhee, H; Yang, E, 2007) |
"Human colon cancer HT-29 cells were cultured in vitro and treated with fluorouracil and/or rosiglitazone." | ( Cao, JG; Dong, L; Liu, HQ; Qin, Y; Sun, L; Tang, XQ; Xia, H; Zhang, YQ, 2007) |
"Two human colon cancer cell lines (HCT-15 and HT-29) were treated with 5-FU and celecoxib, alone and in combination." | ( Bae, YM; Chun, WJ; Lim, YJ; Rhee, JC, 2007) |
"Human colon cancer cells were treated with vehicle or mesalazine (4 mm or 40 mm)." | ( Ahluwalia, A; Chai, J; Chu, EC; Tarnawski, AS, 2007) |
"One of the major problems in treating colon cancer is chemoresistance to cytotoxic chemotherapeutic agents." | ( Baillie, GS; Brunton, VG; Frame, MC; Houslay, MD; Leslie, NR; McEwan, DG, 2007) |
"Treatment of human colon cancer RKO cells with 10 micromol/L 5-FU resulted in significantly increased levels of p53 protein with maximal induction observed at 24 h." | ( Chu, E; Ju, J; Kudo, K; Schmitz, JC; Song, B, 2007) |
"One of the most promising strategies in colon cancer therapy is the sensitization of cancer cells to natural proapoptotic cytokines, such as death ligands and interferons, which are able to eliminate abnormal cells." | ( Pajak, B, 2007) |
"Patients with stage II colon cancer were randomised to either adjuvant chemotherapy with 5-FU/LV (100 mg m(-2) LV+450 mg m(-2) 5-FU weekly, weeks 1-6, in 8 weeks cycles x 7) or surveillance only." | ( Gnant, M; Greil, R; Herbst, F; Hofbauer, F; Jagoditsch, M; Jakesz, R; Rabl, H; Samonigg, H; Schaberl-Moser, R; Schippinger, W; Steger, GG; Thaler, J; Thödtmann, R; Tschmelitsch, J; Wohlmuth, P, 2007) |
"A 57-year-old woman with metastatic colon cancer was receiving oxaliplatin, fluorouracil and leucovorin every 2 weeks and showed a partial response to therapy." | ( Abad, J; Borrás-Blasco, J; Casterá, E; Galan-Brotons, A; Giner-Marco, V; Rosique-Robles, D; Vicent Verge, JM, 2007) |
"Treatment with rifampicin in colon cancer LS180 cells, a cell line known to express endogenous PXR, also inhibited apoptosis." | ( Liu, M; Xie, W; Zhai, Y; Zhou, J, 2008) |
"An 82-year-old female with unresectable colon cancer accompanied by multiple lung metastasis was treated with S-1." | ( Arita, A; Fujimoto, M; Mochizuki, K; Sakai, Y, 2008) |
"A 48-year-old woman, diagnosed as colon cancer with metastases in the liver, lung, bone and left rectus abdominis, developed refractory left abdominal pain in spite of escalating administration of opioids and nerve block therapy, and intrathecal analgesia was applied." | ( Chigusa, S; Ikegaki, J; Kaetsu, H; Kato, H; Kurihara, Y, 2008) |
"Data sets of 855 colon cancer patients treated between 1992 and 1999 within a multicenter adjuvant trial comparing 5-FU modulation with folinic acid or interfereron-alpha were examined." | ( Baumann, W; Ette, C; Formentini, A; Henne-Bruns, D; Kornmann, M; Kreuser, ED; Kron, M; Link, KH; Sander, S; Staib, L, 2008) |
"Human colon cancer cell lines HCT116-XIAP(+/+) cells and HCT116-XIAP(-/-) cells were treated with various concentrations of rosiglitazone." | ( Chan, KW; Dai, Y; Gu, Q; Lan, HY; Li, Z; Ma, J; Qiao, L; Wang, Y; Wong, BC; Wong, BL; Zou, B, 2008) |
"DR5 expression was assessed on human colon cancer cell lines using flow cytometry, and cellular cytotoxicity after TRA-8 treatment, alone and in combination with SN-38, was determined by measuring cellular ATP levels." | ( Buchsbaum, DJ; Kim, H; LoBuglio, AF; Nan, L; Oliver, PG; Wang, W; Zhou, T; Zinn, KR, 2008) |
"The X-ACT trial (Xeloda in Adjuvant Colon Cancer Therapy) compared traditional bolus 5-FU/LV (as per the Mayo Clinic regimen) with capecitabine, in the adjuvant treatment of 1987 stage III colon cancer patients." | ( Cassidy, J; Glen, H, 2008) |
"In the colitis-associated colon cancer (CAC) model, we induced colonic tumors in C57/BL6 mice by azoxymethane and dextran sulfate sodium administration, and evaluated simvastatin's effect on tumor growth." | ( Cho, SJ; Jung, HC; Kim, JM; Kim, JS; Lee, JY; Song, IS, 2008) |
"In the recent X-ACT (Xeloda in Adjuvant Colon cancer Therapy) trial, oral capecitabine (Xeloda) demonstrated superior efficacy and an improved safety profile compared with infused fluorouracil + leucovorin (folinic acid) [FU+LV] in patients with Dukes' C colorectal cancer." | ( Amadori, D; Antonuzzo, L; Barone, C; Bertetto, O; Carlo Merlano, M; Di Costanzo, F; Gasperoni, S; Labianca, R; Longo, F; Luppi, G; Mansueto, G; Ravasio, R; Sobrero, A; Vinante, O, 2008) |
"Human colon cancer cells DLD1-TRAIL/R, with acquired resistance to TRAIL, were firstly transfected with Bcl-XL siRNA for 24 h followed by the treatment of TRAIL protein." | ( Chen, LL; Chen, W; He, C; Hu, JZ; Huang, XF; Zhou, W; Zhu, HB, 2008) |
"The blockade of 5-LOX inhibits colon cancer cell proliferation both in vitro and in vivo and may prove a beneficial chemopreventive therapy in colon cancer." | ( Adrian, TA; Bell, RH; Bentrem, DJ; Ding, XZ; Kennedy, TJ; Melstrom, LG; Rao, SM; Salabat, MR; Strouch, M; Talamonti, MS; Ternent, CA; Witt, RC, 2008) |
"We reported a case of super-elderly colon cancer with peritoneal dissemination effectively treated with modified FOLFOX6 chemotherapy." | ( Fujita, S; Ishida, H; Kabuto, T; Nakaguchi, K; Wada, A; Watanabe, Y, 2008) |
"The incidence of tumors/polyps in the colon cancer of rats and treated with morin showed reduced incidence (40%) of tumors, as compared to DMH (100%) treated rats." | ( Karthik Kumar, V; Nalini, N; Vennila, S, 2009) |
"The data set assembled by the Adjuvant Colon Cancer Endpoints Group, a collection of individual patient data from 18 trials and more than 20,800 patients testing fluorouracil-based adjuvant therapy in patients with stage II or III colon cancer, was analyzed." | ( Andre, T; Buyse, M; de Gramont, A; Francini, G; Goldberg, R; Green, E; Grothey, A; Haller, D; Labianca, R; O'Callaghan, C; O'Connell, MJ; Sargent, D; Seitz, JF; Sobrero, A; Yothers, G; Zheng, Y, 2009) |
"Despite recent progress, colon cancer is often resistant to combination chemotherapy, highlighting the need for development of novel therapeutic approaches." | ( Gaub, MP; Guenot, D; Guérin, E; Larsen, AK; Lelong-Rebel, I; Nicolet, C; Oudet, P; Pencreach, E; Voegeli, AC, 2009) |
"Twenty-five patients diagnosed with colon cancer at an initial, intermediate and late phase submitted to specifically devised therapy were assessed." | ( Busamia, BE; Campos, ML; Dubersarsky, C; Finkelberg, AB; Jarchum, G; Lavarda, M; Linares, JA; Mazzeo, MA, 2009) |
"The treatment of the colon cancer cell lines SW480 and DLD-1 with paclitaxel resulted in increased activation of the MAPK pathway, which was blocked by PD98059, a MEK inhibitor." | ( Akiyoshi, T; Katano, M; Koga, K; Mibu, R; Nagai, S; Nakamura, M; Sato, N; Wada, J; Xu, R; Yanai, K, 2009) |
"Chinese drug ZW3 for the treatment of colonic cancer could improve the main clinical symptoms, improve the QOL, increase body weight and prolong the survival time of patients, showing a favorable integral effect." | ( Shan, ZZ; You, JL; Zhou, LY, 2009) |
"In a further study of compounds in colon cancer, we used half of the IC(50) dose, values in combined treatments of Rg3 (50 microM) with conventional agents - docetaxel (5 nM), paclitaxel (10 nM) cisplatin (10 microM) and doxorubicin (2 microM)." | ( Choi, SS; Han, SB; Hong, JT; Kim, SM; Kim, Y; Lee, SY; Moon, DC; Oh, KW; Yuk, DY, 2009) |
"Our data demonstrate that treatment of colon cancer cells with sorafenib + vorinostat activates CD95 via de novo ceramide synthesis that promotes viability via autophagy or degrades survival via either the extrinsic or intrinsic pathways." | ( Dent, P; Graf, M; Grant, S; Houghton, PJ; Mitchell, C; Park, MA; Rahmani, M; Voelkel-Johnson, C; Walker, T; Yacoub, A, 2009) |
"In spite of improvements in care of colon cancer patients, prevention may enable potential patients to avoid cancer therapy." | ( Marshall, JR, 2009) |
"Treatment of p53 mutant colon cancer cells with 5-FU led to an elongated G1 in a Mirk-dependent manner, as G1 was shortened by ectopic overexpression of cyclin D1 mutated at the Mirk phosphorylation site (T288A), but not by wild-type cyclin D1." | ( Ewton, DZ; Friedman, E; Hu, J; Jin, K; Park, S, 2009) |
"In addition, after human colon cancer cell lines were treated with Survivin siRNA and/or 5-fluorouracil, MTT assay and flow cytometry were used to analyze cell proliferation and apoptosis." | ( Cai, CX; Cai, M; Tao, KX; Wang, GB, 2009) |
"For patients with T3N0M0 colon cancer without known risk factors, the necessity of chemotherapy has no definite consensus." | ( Cho, YB; Chun, HK; Kim, HC; Lee, WY; Yun, HR; Yun, SH, 2009) |
"Human colonic cancer cell line SW620 was treated with EGCG at 40, 60 and 80 micromol/L and cultured in RPMI 1640 medium for 0, 24, 48 and 72 h." | ( Chen, XQ; Li, MS; Song, YG; Wu, JB; Yang, XQ, 2009) |
"After HT-29 colon cancer cells were treated with norcantharidin, cell apoptosis increased remarkably." | ( Agrez, M; Chen, R; Lin, P; Liu, E; Liu, X; Niu, J; Niu, W; Peng, C; Wang, J; Xu, K; Zhang, Z, 2009) |
"In the present study, the human colon cancer cell lines HCT116 and HT29 were used to examine the relationships between Met activation, EGCG treatment, and H(2)O(2) generation." | ( Dashwood, RH; Larsen, CA, 2009) |
"An 82-year-old man with unresectable colon cancer liver metastases was referred to our department for chemotherapy with the FOLFOX protocol." | ( Hatakeyama, K; Muneoka, K; Sakata, J; Sasaki, M; Shirai, Y; Wakai, T, 2009) |
"HCT116 and HT29 colon cancer cells were treated with LBH589 or vorinostat and growth inhibition, acetylation status and apoptosis were analyzed in response to treatment using MTS, Western blotting and flow cytometric analyses." | ( Fazzone, W; Groshen, S; LaBonte, MJ; Ladner, RD; Lenz, HJ; Wilson, PM, 2009) |
"A 79-year-old woman with colon cancer and multiple liver metastases was admitted to our hospital for systemic chemotherapy." | ( Fujita, J; Hirata, T; Kinjyo, F; Kobashikawa, K; Matayoshi, R; Nakamura, M; Ohshiro, M; Takaki, R; Tamura, J, 2009) |
"We report a case of ascending colon cancer successfully treated for synchronous liver metastases with mFOLFOX6 after a resection of the primary tumor." | ( Hazama, S; Nakatsu, H; Oka, M; Tokuhisa, Y; Tomochika, S; Yoshida, S; Yoshino, S, 2009) |
"Azoxymethane-induced colon cancer animals were treated with 400 mg/kg body weight of W." | ( Amanullah, S; Basha, MI; Dinda, AK; Muralikrishnan, G; Shakeel, F, 2010) |
"Furthermore, treatment of colon cancer SW620-bearing nude mice with sunitinib plus TRAIL resulted in more significant tumor growth inhibition (52." | ( Cai, T; Ding, W; He, Q; Lu, W; Tu, C; Wu, R; Yang, B; Yang, L; Zhu, H, 2010) |
"Interestingly, treating pancreatic and colon cancer cells with valproic acid (VPA, 2-propylpentanoic acid), a known histone deacetylase (HDAC) inhibitor, leads to up-regulation of GRP78, an endoplasmic reticulum chaperone immunoglobulin-binding protein." | ( Bayer, TA; Iffland, L; Rossner, C; Schweyer, S; Tamboli, IY; Venkataramani, V; Walter, J; Wirths, O, 2010) |
"We report a resected case of ascending colon cancer with left supraclavicular and paraaortic lymph nodes and liver metastases which completely responded in terms of metastases but not the primary tumor to FOLFOX4 therapy." | ( Fuji, H; Furumoto, K; Ito, D; Kogire, M; Kojima, H; Mizuno, R; Mori, T; Okuno, M; Takaya, H, 2010) |
"Human COLO-205 colon cancer cells were cultured and treated with beta-estradiol for 24 h." | ( Doucet, K; Duke, V; Johnson, N; Morra, A; Wilkins, HR, 2010) |
"Unresectable chemorefractory colon cancer liver metastases treated with (90)Y radioembolization in 28 patients were evaluated at pre- and posttreatment multidetector computed tomographic (CT) and FDG PET scans." | ( Atassi, B; Berggruen, S; Nikolaidis, P; Rezai, P; Rezvani, M; Salem, R; Tochetto, SM; Yaghmai, V, 2010) |
"Changes in attenuation of colon cancer liver metastases treated with (90)Y radioembolization correlate highly with metabolic activity at FDG PET and may be useful as an early surrogate marker for assessing treatment response." | ( Atassi, B; Berggruen, S; Nikolaidis, P; Rezai, P; Rezvani, M; Salem, R; Tochetto, SM; Yaghmai, V, 2010) |
"Forty-eight-hour treatment of colon cancer HCT-116 and HT-29 cells with FOLFOX resulted in 60-70% survival, accompanied by a marked activation of insulin like growth factor-1 receptor (IGF-1R) and minor to moderate increase in epidermal growth factor receptor (EGFR), v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 (HER-2) as well as v-akt murine thymoma viral oncogene homolog 1 (AKT), cyclooxygenase-2 (COX-2) and cyclin-D1." | ( Elliott, AA; Gupta, D; Majumdar, AP; Patel, BB; Sengupta, V; Yu, Y, 2010) |
"IL-6 treatment of colon cancer cells resulted in an increase in DNMT1 expression, independent of de novo gene expression." | ( Egan, LJ; Foran, E; Garrity-Park, MM; Limburg, PJ; Mureau, C; Newell, J; Smyrk, TC, 2010) |
"While many patients with early-stage colon cancer are cured with surgery alone, the standard of care remains a uniform approach to adjuvant chemotherapy based primarily on tumor stage." | ( Gangadhar, T; Schilsky, RL, 2010) |
"Molecular markers in colon cancer are needed for a more accurate classification and personalized treatment." | ( Creemers, GJ; Fariña-Sarasqueta, A; Lemmens, VEPP; Moerland, E; Rutten, HJT; van den Brule, AJC; van Lijnschoten, G, 2010) |
"In this study, we treated human colon cancer HT-29 cells with SAA and SBA, and found a significant exposure time-dependent increase of cytotoxicity in both treatments, with a higher cytotoxicity for 24 h with SAA (IC(50) = 5 mM) than SBA (IC(50) = 10 mM)." | ( Che, CT; Cheung, FW; Kochi, M; Liu, WK; Sakagami, H, 2010) |
"Chemotherapy is the main treatment for colon cancer, while multidrug-resistance is the main reason for chemotherapy failure and tumor relapse." | ( Bi, F; Lang, N; Liu, M; Liu, Z; Qiu, M; Tang, QL, 2010) |
"WiDr human colon cancer cells were treated with 150, 300, 600 or 1200 ppm of soy saponin to determine the effect on cell growth, cell morphology, alkaline phosphatase (AP) and protein kinase C (PKC) activities, and P53 protein, c-Fos and c-Jun gene expression." | ( Chen, YH; Chien, YW; Huang, WH; Lin, SH; Tsai, CY, 2010) |
"In human colon cancer cells (HCT116, HT29) and non-immortalized primary fetal colon cells (FHC), CA- and CE-treatment upregulated cellular protein levels of Nrf2 and established Nrf2 targets involved in the antioxidant response including heme oxygenase 1 (HO-1) and gamma-glutamyl-cysteine synthetase (gamma-GCS, catalytic subunit)." | ( Bause, AS; Jiang, T; Lamore, SD; Villeneuve, NF; Wondrak, GT; Zhang, DD, 2010) |
"In addition, the growth of the colon cancer cell lines Caco-2 and colon-26 was significantly inhibited by treatment with the 3 hanabiratakelides." | ( Hashimoto, T; Inose, T; Kimura, T; Kokudo, N; Yamamoto, K; Yoshikawa, K, 2010) |
"Human colon cancer cells SW480 were divided into two groups: SW480 cells in experimental group were treated with NS398 in different concentrations(25 micromol/L, 50 micromol/L, 100 micromol/L and 200 micromol/L) for 48 h or 72 h." | ( Ni, SM; Wang, SM; Wu, X; Yang, G; Ye, M, 2010) |
"Altogether, our results suggest that colon cancer cells can acquire rhTRAIL resistance by primarily reducing the basal procaspase 8/c-FLIP ratio and by increasing active caspase 8 degradation after rhTRAIL treatment." | ( De Jong, S; De Vries, EG; Ek, WB; Le, PT; Pennarun, B; Spierings, DC; Van Geelen, CM, 2010) |
"Azoxymethane induced colon cancer animals were treated with 400 mg/kg body weight of W." | ( Dinda, AK; Muralikrishnan, G; Shakeel, F, 2010) |
"Pyrvinium treatment of colon cancer cells with mutation of the gene for adenomatous polyposis coli (APC) or β-catenin inhibits both Wnt signaling and proliferation." | ( Cselenyi, CS; Ghidu, VP; Hang, BI; Hanson, AJ; Jernigan, KK; Kim, K; LaFleur, B; Lee, E; Lee, LA; Melancon, B; Meyers, KC; Miller, DM; Orton, D; Salic, A; Schneider, J; Sulikowski, GA; Tahinci, E; Thorne, CA; Waterson, AG, 2010) |
"Stage III colon cancer patients receiving standard adjuvant oxaliplatin/capecitabine chemotherapy were vaccinated at the same time with keyhole limpet haemocyanin (KLH) and carcinoembryonic antigen (CEA)-peptide pulsed DCs." | ( Aarntzen, EA; Adema, GJ; de Boer, A; de Vries, IJ; Figdor, CG; Lesterhuis, WJ; Preijers, FW; Punt, CJ; Scharenborg, NM; van de Rakt, M; van Spronsen, DJ, 2010) |
"In human colon cancer cell peritoneal xenografts, MTOB treatment decreased tumor burden and induced tumor cell apoptosis." | ( Grossman, SR; Kovi, RC; Lyle, S; Paliwal, S; Parker, D; Rajeshkumar, B; Schiffer, CA; Straza, MW; Trenh, P; Whalen, GF, 2010) |
"We report a case of high CEA advanced colon cancer, which we were able to down stage after treatment with FOLFIRI-1." | ( Egawa, H; Kadokawa, Y; Kawabe, A; Nakajima, S; Sonoda, K; Yamamoto, T, 2010) |
"HCT116 and HT29 colon cancer cells for cell viability assay were treated with PXD101 and/or SN-38, the active form of irinotecan." | ( Cho, DH; Hong, YS; Jang, SJ; Jung, KA; Kim, JC; Kim, SM; Kim, TW; Lee, JS; Moon, DH; Na, YS; Ryu, MH, 2011) |
"Many patients with early-stage colon cancer are cured with surgery alone, even if the standard of care remains an uniform approach to adjuvant chemotherapy based primarily on tumour stage." | ( Cinieri, S; Colucci, G; Fazio, N; Lombardi, L; Maiello, E; Morelli, F; Orlando, L; Santini, D; Silvestris, N; Tonini, G, 2010) |
"Recurrence of colon cancer, which affects nearly 50% of patients treated by conventional therapeutics, is thought to be due to re-emergence of chemotherapy-resistant cancer stem/stem-like cells (CSCs)." | ( Kanwar, SS; Majumdar, AP; Nautiyal, J; Padhye, S; Patel, BB; Sarkar, FH; Yu, Y, 2011) |
"Five colon cancer and two adenoma cell lines, human ex vivo adenomas and normal colonic epithelium were treated with aspirin or sulindac combined with rhTRAIL." | ( de Jong, S; de Vries, EG; Heijink, DM; Hollema, H; Jalving, M; Kleibeuker, JH; Koornstra, JJ; Koster, R; Oosterhuis, D; Sloots, IA, 2011) |
"Patients with colon cancer undergoing adjuvant therapy with infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX) were randomly assigned to Ca/Mg (1g calcium gluconate plus 1g magnesium sulfate pre- and post-oxaliplatin) or placebo, in a double-blinded manner." | ( Alberts, SR; Chitaley, U; Dentchev, T; Grothey, A; Kugler, JW; Loprinzi, CL; Nikcevich, DA; Novotny, PJ; Silberstein, PT; Sloan, JA; Wender, DB, 2011) |
"Treatment of HCT-116 human colon cancer cells with MCPP was found to induce a number of signature endoplasmic reticulum (ER) stress markers; and up-regulation of CCAAT/enhancer-binding protein homologous protein (CHOP) and glucose-regulated protein (GRP)-78, phosphorylation of eukaryotic initiation factor-2α (eIF-2α), suggesting the induction of ER stress." | ( Chang, CS; Chen, JH; Cheung, CW; Huang, SM; Ko, SH; Lin, YH; Liu, JF; Lu, DY; Tang, CH; Wong, KL, 2011) |
"HCT-116 human colon cancer cells were treated with 0." | ( Kaneno, FM; Kaneno, R; Luo, J; Naiditch, H; Shurin, GV; Shurin, MR, 2011) |
"Raman spectra of the cultured HCT116 colon cancer cells treated with roscovitine at different concentrations (0, 5, 10, 25 and 50 μM) were recorded in the range 400-1850 cm(-1)." | ( Akyuz, S; Akyuz, T; Arisan, ED; Balci, K; Coker, A; Ozalpan, A; Ozel, AE; Palavan-Unsal, N, 2011) |
"We continued the chemotherapy for her colon cancer by prescribing S-1, it proved ineffective." | ( Hanatate, F; Kobayashi, K; Komaki, C, 2011) |
"We treated colon cancer cell lines heterozygous for gain-of-function and wild-type β-catenin with sulindac." | ( Arlt, F; Fichtner, I; Herrmann, P; Lemm, M; Sack, U; Schlag, PM; Shoemaker, RH; Smith, J; Stein, U; Walther, W, 2011) |
"The standard treatment for colon cancer is surgical excision." | ( , 2011) |
"Finally, calcimycin treatment of human colon cancer cells inhibited metastasis formation in xenografted immunodeficient mice." | ( Aumann, J; Fichtner, I; Lemos, C; Sack, U; Schlag, PM; Scudiero, D; Selby, M; Shoemaker, RH; Stein, U; Walther, W, 2011) |
"We report a case of undifferentiated colon cancer treated with FOLFIRI therapy." | ( Fujiwara, K; Iwashita, T; Nagayoshi, Y; Nakahara, C; Yamasaki, T, 2011) |
"A patient with colon cancer who had received an overdose of fluorouracil was successfully treated with a five-day course of oral uridine triacetate." | ( McEvilly, M; Popelas, C; Tremmel, B, 2011) |
"We examined ESA therapy in lung and colon cancer patients receiving chemotherapy in the VA from 2002 to 2008 to ascertain trends in and predictors of ESA use." | ( Browning, MM; Hynes, DM; Lee, TA; Michaelis, LC; Ozer, H; Stroupe, KT; Tarlov, E; Weichle, TW; Zhang, QL, 2012) |
"Among 17,014 lung and 4,225 colon cancer patients, those treated after the March 2007 FDA decision had 65% (lung OR 0." | ( Browning, MM; Hynes, DM; Lee, TA; Michaelis, LC; Ozer, H; Stroupe, KT; Tarlov, E; Weichle, TW; Zhang, QL, 2012) |
"Two human colon cancer cell lines SW480 and LOVO were treated with IFN-alpha alone or gefitinib alone or IFN-alpha plus gefitinib." | ( He, F; Huang, L; Wang, F; Yang, L, 2011) |
"The present patient had metastatic colon cancer and was admitted to our hospital with a floating sensation and general malaise on day 4 after undergoing the last of 4 cycles of a 7th round of chemotherapy with XELOX." | ( Goto, H; Hara, K; Higuchi, K; Hijioka, S; Kawai, H; Kondo, S; Mizuno, N; Nakamura, M; Niwa, Y; Ogura, T; Sawaki, A; Tajika, M; Yamao, K, 2011) |
"DCT treatment of human colon cancer cells resulted in time-dependent, 10-fold increased MMP1 expression, and DCT-induced cell invasion was also blocked by pre-treatment with anti-MMP1 antibody." | ( Belo, A; Chahdi, A; Cheng, K; Khurana, S; Raufman, JP; Saxena, N; Xie, G, 2011) |
"Patients with advanced colon cancer who progressed after prior treatment regimens received intravenous patupilone (6." | ( Bennouna, J; Bridgewater, J; Campone, M; Casado, E; Cerman, J; Delord, JP; Dvorak, J; Melichar, B; Salazar, R; Sguotti, C; Tabernero, J; Tan, E; Urban, P; Viraswami-Appanna, K; Vitek, P, 2011) |
"Two different human colon cancer cell lines were treated with AngII and Ang1-7." | ( Bellini, G; Bernardi, S; Buri, L; Burrell, LM; De Manzini, N; Fabris, B; Giacomel, G; Palmisano, S; Sabato, N; Toffoli, B; Velkoska, E; Zanconati, F; Zennaro, C, 2012) |
"These effects were confirmed in vivo in colon cancer xenograft models with demonstrations that IGF-I receptor stimulation was sufficient to generate a 45% increase in tumor cell proliferation, along with a 25% to 50% increase in chemotherapy-induced tumor growth delay." | ( Baker, JH; Kyle, AH; Minchinton, AI, 2012) |
"Moreover, Gli3 siRNA sensitized colon cancer cells to treatment with anti-cancer agents (5-FU and bevacizumab)." | ( Kang, HN; Kim, JS; Oh, SC; Yoo, YA, 2012) |
"Understanding how colon cancer cells survive within the inflammatory milieu of a tumor, and developing approaches that increase their sensitivity to inflammatory cytokines, may ultimately lead to novel approaches for colon cancer therapy and prevention." | ( Giardina, C; Kuratnik, A; Mellone, BG; Senapati, VE; Vella, AT; Verma, R, 2012) |
"Considering the increased colon cancer risk associated with chronic colitis, we have therefore examined the effects of long-acting hGly(2)GLP-2, as well as of endogenous GLP-2 using the antagonist hGLP-2(3-33) in two novel models of inflammation-associated colon cancer: rats fed the carcinogen 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and a high-fat diet (HFD) for one or three cycles, and mice with chronic dextran sodium-sulfate (DSS)-induced colitis administered AOM." | ( Brubaker, PL; El-Zimaity, HM; Trivedi, S; Wiber, SC, 2012) |
"Colitis-associated colon cancer was induced in mice by administration of azoxymethane, followed by 3 cycles of oral administration of dextran sodium sulfate." | ( Becker, C; Dornhoff, H; Markl, J; Mudter, J; Neufert, C; Neurath, MF; Rosfa, S; Siebler, J; Strand, D; Tenzer, S; Wirtz, S, 2012) |
"HT-29 colon cancer cells and LT97 colorectal micro-adenoma cells derived from a patient with FAP, were exposed to low dose celecoxib and UDCA alone or in combination with tauro-cholic acid (CA) and tauro-chenodeoxycholic acid (CDCA), mimicking bile of FAP patients treated with UDCA." | ( Marian, B; Nagengast, FM; Peters, WH; Roelofs, HM; Te Morsche, RH; van Heumen, BW, 2012) |
"Human colon cancer cell lines (HCT116, HT29, SW48, SW480) were treated with 5-aza-2'-deoxycytidine (DAC), as a DNA methyltransferase inhibitor, followed by trichostatin A (TSA), as a histone deacetylase inhibitor." | ( Ikehata, M; Iwakawa, S; Ueda, K, 2012) |
"We used a rat model of the colon cancer induced by administration of azoxymethane followed by repeated dextran sodium sulfate ingestion which causes multiple tumor development." | ( Aktan, AO; Attaallah, W; Erdoğan, N; Yalçin, AS; Yilmaz, AM, 2012) |
"LS174T, SW480 and DLD-1 colon cancer cell lines were treated with PP242 an ATP-competitive inhibitor of mTOR, NVP-BEZ235, a dual PI3K/mTOR inhibitor or rapamycin." | ( Blaser, B; Demartines, N; Dormond, O; Dormond-Meuwly, A; Dufour, M; Roulin, D; Waselle, L, 2012) |
"Combined treatment of human HCT116 colon cancer cells with free celecoxib plus tributyrin emulsion inhibited the cellular proliferation more effectively than that of each drug alone, suggesting the possibility of tributyrin emulsion as a potential celecoxib carrier." | ( Hong, SS; Kang, SN; Lee, MK; Lim, SJ, 2012) |
"In the colon cancer xenograft model, the volume of the tumor treated with deguelin was significantly lower than that of the control, and the apoptotic index for deguelin-treated mice was much higher." | ( Cha, MY; Jung, HC; Kang, HW; Kim, JM; Kim, JS; Song, IS, 2012) |
"The proposed model of distal colon cancer is feasible, allows for easy monitoring of tumoral growth by both, macroscopically and molecular imaging, and is suitable for studying the evolution of tumor with implementation of cytotoxic therapy in vivo." | ( Abrantes, AM; Batista, JN; Botelho, MF; Cardinalli, IA; Neves, S; Priolli, DG, 2012) |
"Nude mouse models bearing LoVo colon cancer xenograft were randomized into vehicle control group, untreated control group, axitinib-treated group, 5-FU-treated group and combined treatment group for corresponding treatments." | ( He, B; Xie, F; Zhao, J; Zhao, T, 2012) |
"Human colon cancer DLD-1 cells were treated with 5-FU (10 μΜ) or chloroquine (100 μΜ), or a combination of both." | ( Choi, JH; Lee, YY; Park, BB; Won, YW; Yoon, JS, 2012) |
"Adjuvant chemotherapy for stage III colon cancer is internationally accepted as standard treatment with established efficacy, but the usefulness of adjuvant chemotherapy for stage II colon cancer remains controversial." | ( Ishiguro, M; Ishikawa, T; Kanemitsu, Y; Kotake, K; Matsui, S; Mochizuki, H; Shimada, Y; Sugihara, K; Takahashi, K; Teramukai, S; Tomita, N; Ueno, H; Uetake, H; Watanabe, M, 2012) |
"In conclusion, in colon cancer cells, cisplatin treatment enhances chemoresistance through FXR-dependent and FXR-independent mechanisms involving the expression of BCRP and MRP2, respectively." | ( Briz, O; Gonzalez-Sanchez, E; Herraez, E; Marin, JJ; Romero, MR; Serrano, MA; Vaquero, J, 2012) |
"Two human colon cancer cell lines LOVO and SW480 were cultured and treated with IFN-α2a at a series of dosage, and fluorescence quantitative PCR was carried out to detect the TP mRNA expression levels in these 2 cell lines." | ( Wang, QW; Xia, Q; Zhang, JM, 2012) |
"The loss of expression of miR-34 in colon cancer is in part due to promoter hypermethylation of miR-34, which can be re-expressed with our novel agent CDF, suggesting that CDF could be a novel demethylating agent for restoring the expression of miR-34 family, and thus CDF could become a newer therapeutic agent for the treatment of colon cancer." | ( Levi, E; Majumdar, AP; Roy, S; Sarkar, FH, 2012) |
"This increased apoptosis in human colon cancer cells after RA or DZNep treatment was associated with a ~2." | ( Benoit, YD; Gudas, LJ; Laursen, KB; Lipkin, SM; Witherspoon, MS, 2013) |
"In wild-type p53 colon cancer cells, topotecan treatment activated p53, upregulated the expression of sestrin 2, induced the phosphorylation of the AMPKα subunit at Thr172, and inhibited the mTORC1 pathway." | ( Chen, SP; Deng, R; Feng, GK; Jiang, S; Li, DD; Pan, JX; Sun, T; Wu, XQ; Zeng, YX; Zhang, XS; Zhu, XF, 2012) |
"CT26 mouse colon cancer cells were treated with trichostatin A (TSA; apoptosis inducer) or doxorubicin (DXR; necrosis inducer)." | ( Chihara, Y; Fujii, K; Fujimoto, K; Fujiwara, R; Kuniyasu, H; Kuwada, M; Luo, Y; Ohmori, H; Sasahira, T, 2013) |
"However, a sub-population of colon cancer patients do not respond to 5-FU and this treatment does not provide survival benefit due to chemo resistance." | ( Gao, H; Khan, AQ; Liang, B; Lin, P; Liu, E; Liu, S; Niu, J; Niu, W; Peng, C; Shahbaz, M; Wang, B; Wang, J, 2013) |
"However, the treatment of colon cancer cells with a diet-compatible mixture of oxysterols does not elicit the same responses than individual components added to the cells at the same concentrations at which they are present in the mixture." | ( Biasi, F; Chiarpotto, E; Gamba, P; Gargiulo, S; Guina, T; Leonarduzzi, G; Maina, M; Mascia, C; Poli, G; Sottero, B; Testa, G, 2013) |
"Human and murine colon cancer cell lines were subjected to mild hyperthermia (40-42°C), and treated with chemotherapy, similar to clinical protocols." | ( Clavien, PA; Gertsch, P; Graf, R; Humar, B; Jang, JH; Lehmann, K; Oberkofler, CE; Rickenbacher, A; von Boehmer, L; Vonlanthen, R, 2012) |
"Treatment of colon cancer with an antagonist of growth hormone-releasing hormone (GHRH), JMR-132, results in a cell cycle arrest in S-phase of the tumor cells." | ( Block, NL; Buchholz, S; Datz, C; Hohla, F; Krishan, A; Rick, FG; Schally, AV; Seitz, S; Stadlmayr, A; Szalontay, L, 2012) |
"Patients with resected stage III colon cancer aged ≥75 years diagnosed in 1997-2004 who received adjuvant chemotherapy (N = 216) were included as well as a random sample (N = 341) of patients who only underwent surgery." | ( Hoeben, KW; Janssen-Heijnen, ML; Rutten, HJ; van de Wouw, AJ; van Spronsen, DJ; van Steenbergen, LN, 2013) |
"A total of 22 patients with colon cancer receiving chemotherapy were included in the efficacy analyses." | ( Nakayama, Y; Shinohara, Y; Takahashi, K; Torigoe, T; Yamaguchi, K, 2012) |
"A total of 149 patients with advanced colon cancer undergoing curative resection followed by adjuvant chemotherapy(FOLFOX6 protocol) were included." | ( Cai, CN; Guan, XD; Jia, YB; Li, J; Li, PP; Xie, YY; Zhang, BM, 2012) |
"Among 391 patients with Stage III colon cancer, 229 patients received adjuvant oxaliplatin, fluorouracil and leucovorin chemotherapy (87 (43." | ( Jang, NY; Kang, SB; Kim, DW; Kim, JH; Kim, JS; Kim, JY; Kim, YJ; Lee, HS; Lee, JS; Lee, KW, 2013) |
"Therefore, for colon cancer patients aged ≥65, oxaliplatin, fluorouracil and leucovorin chemotherapy can be recommended as safe and effective adjuvant chemotherapy after curative surgery in Asia." | ( Jang, NY; Kang, SB; Kim, DW; Kim, JH; Kim, JS; Kim, JY; Kim, YJ; Lee, HS; Lee, JS; Lee, KW, 2013) |
"CD133-positive cancer stem cells in colon cancer are resistant to conventional chemotherapy." | ( Deng, Y; Fu, X; Lin, EH; Mo, J; Su, Q; Zhang, Y, 2013) |
"We report on an 86-year-old woman with colon cancer with liver metastasis who was treated with 5-fluorouracil, folinic acid, and bevacizumab." | ( Boudou-Rouquette, P; Brezault, C; Chaussade, S; Coriat, R; Dhooge, M; Dréanic, J; Goldwasser, F; Mir, O; Perkins, G, 2013) |
"This study in 716 colon cancer patients evaluates if a combined instead of a single marker analysis of mismatch repair (MMR) status and thymidylate synthase (TS) expression could individualize the treatment decision." | ( Edler, D; Hallström, M; Karlberg, M; Öhrling, K; Ragnhammar, P, 2013) |
"Data also indicate that MMR proficient colon cancer with high TS expression has a better response to adjuvant 5-FU-based chemotherapy." | ( Edler, D; Hallström, M; Karlberg, M; Öhrling, K; Ragnhammar, P, 2013) |
"Stage III colon cancer patients aged 65+ years initiating chemotherapy between 2003 and 2006 were examined using cancer registry data linked with Medicare claims." | ( Brookhart, MA; Carpenter, WR; Glynn, RJ; Mack, CD; Meyer, AM; Sandler, RS; Stürmer, T, 2013) |
"In vitro treatment of HCT-116 colon cancer cells with 3,4-DHPAA and EGCG exhibited an additive antiproliferative effect, while methylation of 3,4-DHPAA was significantly decreased." | ( Abgaryan, N; Aronson, WJ; Carpenter, CL; de Oliveira, DM; Heber, D; Henning, SM; Lee, RP; Vicinanza, R; Wang, P; Zhang, Y, 2013) |
"3-Bromopyruvate inhibited colonic cancer cell proliferation, but the effect was not always additive to that of biguanides and an additive effect was more notable in combined treatment with 3-bromopyruvate and 2-deoxyglucose." | ( Buxhoeveden, M; Desbordes, C; Gengel, N; Kleinschmit, J; Lea, MA; Qureshi, MS, 2013) |
"We report a case of recurrent colon cancer successfully treated by mFOLFOX6 and FOLFIRI, and maintaining a complete response(CR)over the long-term." | ( Hamada, T; Ohashi, S; Ohta, K; Taniguchi, E; Yamagami, Y; Yoshikawa, M, 2013) |
"HT-29 and SW-480 colon cancer and normal CCD-18Co colon fibroblast cells were treated with curcuminoids previously analyzed by HPLC." | ( Angel-Morales, G; Jutooru, I; Mertens-Talcott, SU; Noratto, GD; Safe, S, 2013) |
"To elevate MDA-7/IL-24 level for colon cancer treatment, we successfully developed a small-molecule compound SC144 with the ability to up-regulate MDA-7/IL-24 expression via direct binding and stabilizing MDA-7/IL-24 in human colon cancer cells." | ( Debnath, B; Garofalo, A; Grande, F; Imada, T; Masuda, M; Neamati, N; Oshima, T; Xu, S, 2013) |
"Two hundred and thirty five colon cancer patients treated surgically in a community teaching hospital in Norway between 2007 and 2009 were prospectively examined." | ( Eide, GE; Fjørtoft, I; Furnes, B; Hausken, T; Storli, KE; Søndenaa, K, 2013) |
"The cells of LS180 colon cancer cell line were tested upon treatment with roasted potato fiber extract (AM4) as well as with high (HMW) and low (LMW) molecular weight fractions isolated from the extract, since both may be regarded as/or contain melanoidins." | ( Kandefer-Szerszeń, M; Langner, E; Nunes, FM; Pierzynowski, SG; Pożarowski, P; Rzeski, W, 2013) |
"MAT2A expression is increased in human colon cancer and in colon cancer cells treated with mitogens, whereas silencing MAT2A resulted in apoptosis." | ( Giordano, P; Lu, SC; Mato, JM; Ryoo, M; Skay, A; Tomasi, I; Tomasi, ML, 2013) |
"Mice bearing human colon cancer LS-174T intraperitoneal xenografts were pre-treated with paclitaxel, followed by treatment with (212)Pb-TCMC-trastuzumab and compared with groups treated with paclitaxel alone, (212)Pb-TCMC-HuIgG, (212)Pb-TCMC-trastuzumab and (212)Pb-TCMC-HuIgG after paclitaxel pre-treatment." | ( Baidoo, KE; Brechbiel, MW; Milenic, DE; Yong, KJ, 2013) |
"Mice bearing COLO 320DM human colon cancer xenografts (containing amplified c-MYC) were treated with a TFO targeted to c-MYC in combination with GEM." | ( Boulware, SB; Christensen, LA; Coghlan, L; Finch, RA; Thames, H; Vasquez, KM, 2014) |
"p53-null colon cancer cell lines with different sets of mutations were used to validate the role of GSK3B in sustaining resistance and to characterize cell death mechanisms triggered by chemotherapy when GSK3B is silenced." | ( Bonin, S; Donada, M; Federzoni, E; Giovannoni, R; Grassilli, E; Helin, K; Ianzano, L; Lavitrano, M; Leone, BE; Masiero, L; Narloch, R; Pisano, F; Romano, G; Stanta, G, 2013) |
"Treatment of colon cancer cells (HT29, SW480 and Caco-2) with epidermal growth factor (EGF) caused increased expression of miR-21 and inhibition of AR prevented it." | ( Ramana, KV; Saxena, A; Shoeb, M; Srivastava, SK, 2013) |
"We report a case of advanced relapsed colon cancer, which had multiple liver and spleen metastasis, controlled for about two years by capecitabine therapy." | ( Hashimoto, T; Kimura, S; Toyono, M; Usuba, O; Yokoyama, M, 2013) |
"Between 2002 and 2011, 333 Stage III colon cancer patients had surgery performed in our institute, and we studied 25 of them on our chemotherapy regimen." | ( Hanaoka, Y; Hashimoto, M; Kuroyanagi, H; Matoba, S; Moriyama, J; Toda, S; Tomizawa, K; Udagawa, H; Watanabe, G, 2013) |
"While it protected mice from colon cancer in a model of inflammation-triggered carcinogenesis (azoxymethane and dextran sodium sulfate treatment), it promoted growth of xenografted tumor cells." | ( Brigelius-Flohé, R; Chu, FF; Esworthy, RS; Florian, S; Kipp, AP; Müller, MF; Osterhoff, M; Pommer, S, 2013) |
"Future colon cancer therapeutic trials, with inclusion of correlative molecular markers, should be designed to permit evaluation of survival and/or response to treatment in women separately from men." | ( Atreya, CE; Bertagnolli, MM; Compton, CC; Donner, DB; Goldberg, RM; Mayer, RJ; Niedzwiecki, D; Saltz, LB; Warren, RS; Weinberg, VK; Ye, C; Zuraek, MB, 2013) |
"In this study we used colon cancer cell lines to study the cellular and molecular events that take place during co-treatment with NaB, EC and EGCG." | ( Cascante, M; Centelles, JJ; Dudeja, PK; Sánchez-Tena, S; Vizán, P, 2013) |
"Six months later, colon cancer was discovered and the patient underwent surgical procedure and chemotherapy with capecitabine thereafter." | ( Badzek, S; Bilic, E; Golem, H; Gorsic, I; Kekez, D; Librenjak, N; Miletic, V; Plestina, S; Prejac, J, 2013) |
"Human colon cancer LoVo cells were divided into three groups: phorbol 12-myristate 13-acetate (PMA) was used to induce the activation of SphK1 in the PMA group, N,N-dimethylsphingosine (DMS) used to suppress the activity of SphK1 in DMS group, and the cells treated with equal amount of 0." | ( Huang, JA; Liu, SQ; Qin, MB; Su, YJ; Tang, GD, 2013) |
"HCT-116 colon cancer cells were treated with CPT, OXP, and IL-6 separately or in combination in a time and dose-dependent manner and examined for phosphorylated and non-phosphorylated RKIP and STAT3 via Western blot analysis." | ( Brilliant, K; Chatterjee, D; Cross-Knorr, S; Guevara, S; Lu, S; Perez, K; Pisano, C; Quesenberry, PJ; Resnick, MB, 2013) |
"Current treatment of colon cancer depends on traditional cytotoxic agents with limited effects." | ( Bode, AM; Chen, H; Dong, Z; Jung, SK; Kim, DJ; Lee, HJ; Lee, KW; Lee, MH; Lee, SY; Lim, TG; Shin, A; Surh, YJ, 2013) |
"Contrarily, patients with colon cancer stage III are routinely offered chemotherapy, but due to expected adverse effects and frailty, elderly patients are often excluded from standard protocols." | ( Ågesen, TH; Guren, MG; Lothe, RA; Nesbakken, A; Skotheim, RI; Sveen, A; Tveit, KM, 2013) |
"Treatment of a human colon cancer cell line (HCT116) with 100 μM sodium arsenite increased SRSF3-PTC mRNA levels without changing SRSF3-FL mRNA levels." | ( Akaike, Y; Kajita, K; Kano, S; Kita, K; Kurebe, H; Kurokawa, K; Kuwano, Y; Masuda, K; Nishida, K; Nishiyama, C; Rokutan, K; Tanahashi, T, 2014) |
"In all, 353 patients with colon cancer undergoing adjuvant therapy with FOLFOX (fluorouracil, leucovorin, and oxaliplatin) were randomly assigned to intravenous calcium/magnesium before and after oxaliplatin, a placebo before and after, or calcium/magnesium before and placebo after." | ( Atherton, P; Dakhil, SR; Fehrenbacher, L; Flynn, KA; Grothey, A; Lewis, GC; Loprinzi, CL; Qamar, R; Qin, R; Seisler, D, 2014) |
"Treatment of colon cancer cells with 3-AP or 3-AP-Me activated all three ER stress pathways (PERK, IRE1a, ATF6) by phosphorylation of eIF2α and upregulation of gene expression of activating transcription factors ATF4 and ATF6." | ( Berger, W; Enyedy, ÉA; Flocke, LS; Heffeter, P; Jakupec, MA; Jungwirth, U; Keppler, BK; Kowol, CR; Mair, GE; Steinborn, R; Trondl, R, 2014) |
"The treatment of metastatic colon cancer (mCC) utilizes either combination therapies or sequential monotherapy followed by combination therapy in subsequent lines of treatment." | ( Ghosh, S; Loree, JM; Mulder, KE; Spratlin, JL, 2014) |
"A 73-year-old male with sigmoid colon cancer and synchronous lung metastasis was treated with panitumumab, an alone anti-EGFR monoclonal antibody as the third-line therapy." | ( Ichikawa, K; Imai, H; Matsuhashi, N; Nonaka, K; Okumura, N; Osada, S; Sasaki, Y; Takahashi, T; Tanahashi, T; Tanaka, Y; Yamaguchi, K; Yawata, K; Yoshida, K, 2014) |
"Adjuvant treatment of colon cancer relies on fluoropyrimidine-containing regimens as the intravenous formulation, 5-FU, or its oral prodrug, CA, combined with oxaliplatin (FOLFOX and CAPOX)." | ( Ghosh, S; Loree, JM; Mulder, KE; Spratlin, JL, 2014) |
"Among 305 stage III colon cancers registered in a well-defined population in Burgundy between 2004 and 2009, 210 had adjuvant chemotherapy, including 156 with FOLFOX." | ( Bedenne, L; Bouvier, AM; Faivre, J; Hamza, S; Lepage, C; Rollot, F, 2014) |
"Patients with stage IIB or III colon cancer who had undergone curative resection were randomly assigned to receive UFT (300 mg/m(2)) plus leucovorin (75 mg/day) for 6 months (control group, 4 weeks of treatment followed by a 1-week rest, five courses) or for 18 months (study group, 5 days of treatment followed by a 2-day rest, 15 courses)." | ( Baba, H; Hamada, C; Kakeji, Y; Katsumata, K; Koda, K; Kodaira, S; Kondo, K; Matsuoka, J; Morita, T; Nishimura, G; Sadahiro, S; Saji, S; Sasaki, K; Sato, S; Tsuchiya, T; Usuki, H; Yamaguchi, Y, 2014) |
"The efficacy of 5-FU in colon cancer chemo treatment could be improved by nanoencapsulation and combinatorial approach." | ( Anitha, A; Chennazhi, KP; Jayakumar, R; Lakshmanan, VK; Sreeranganathan, M, 2014) |
"Treatment of SW480 cells, a human colon cancer cells, with cucurbitacin-I decreased cell viability and cell proliferation in a concentration-dependent manner." | ( Kim, HJ; Kim, JK; Park, JH, 2014) |
"Treatment of HCT-116 and Caco-2 colon cancer cells with the hypoxia mimic CoCl2 induced the formation of cells with larger cell and nuclear size (PGCCs), while the cells with normal morphology were selectively eliminated." | ( Aranda, E; De la Haba-Rodríguez, JR; Hernandez, V; Jimenez, C; Lopez-Pedrera, C; Lopez-Sánchez, LM; Martinez, A; Muñoz-Castañeda, JR; Peñarando, J; Rodriguez-Ariza, A; Valverde, A, 2014) |
"The NCCN Guidelines for Colon Cancer address diagnosis, pathologic staging, surgical management, perioperative treatment, posttreatment surveillance, management of recurrent and metastatic disease,and survivorship." | ( Bekaii-Saab, T; Benson, AB; Chan, E; Chen, YJ; Cooper, HS; Engstrom, PF; Enzinger, PC; Fenton, MJ; Freedman-Cass, DA; Fuchs, CS; Gregory, KM; Grem, JL; Hunt, S; Kamel, A; Leong, LA; Lin, E; Messersmith, W; Mulcahy, MF; Murphy, JD; Nurkin, S; Rohren, E; Ryan, DP; Saltz, L; Sharma, S; Shibata, D; Skibber, JM; Sofocleous, CT; Stoffel, EM; Stotsky-Himelfarb, E; Venook, AP; Willett, CG, 2014) |
"A total of 255 colon cancer patients treated at the Affiliated Tumor Hospital of Xinjiang Medical University from June 1(st) 2005 to June 1(st) 2008 were enrolled in the study." | ( Han, XN; Liu, YY; Qu, YL; Sun, ZQ; Tang, Y; Wang, HJ; Xu, RW; Yu, XB; Zhao, ZL, 2014) |
"The development of colon cancer was induced in male BALB/c mice with a single intraperitoneal injection of azoxymethane (AOM, 10 mg/kg body weight) and subsequent treatment with 2% dextran sulfate sodium (DSS) in drinking water for 7 days for two cycles." | ( Chang, HK; Kang, SA; Kim, HY; Park, KY; Song, JL, 2014) |
"Another common approach for colon cancer treatment is targeted therapy against the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) pathway." | ( Chen, J; Gu, W; Li, L; Shao, R; Xu, ZP, 2014) |
"Treatment of Caco-2 human colon cancer cells, used as a colon epithelial model, with 50 µM patulin decreased the level of density-enhanced phosphatase-1 (DEP-1) protein to 30% of the control level after 6 h." | ( Katsuyama, A; Kikuchi, H; Konno, T; Shimoyama, S, 2014) |
"Kaplan-Meier plots from colon cancer patients showed a significant treatment benefit in patients with low maspin expression, but not for individuals with medium/high expression." | ( Brydøy, M; Dahl, O; Hestetun, KE; Myklebust, MP, 2015) |
"In patients with colon cancer a low nuclear maspin expression was an independent predictor of benefit from adjuvant chemotherapy with 5-FU/Lev." | ( Brydøy, M; Dahl, O; Hestetun, KE; Myklebust, MP, 2015) |
"In search for novel strategies in colon cancer treatment, we investigated the unique ability of platinum(IV) complex LA-12 to efficiently enhance the killing effects of tumor necrosis factor-related apoptosis inducing ligand (TRAIL), and compared it with the sensitizing action of cisplatin." | ( Ehrmann, J; Hofmanová, J; Hyršlová Vaculová, A; Jelínková, I; Kolář, Z; Kozubík, A; Moyer, MP; Šafaříková, B; Skender, B; Sova, P; Vondálová Blanářová, O, 2014) |
"A 63-year-old woman with colon cancer who was treated with capecitabine as adjuvant chemotherapy presented with vertigo on day 5, and dysarthria and dysphagia on day 7 of the treatment." | ( Ban, T; Ikegaya, Y; Isogai, N; Kawachi, J; Miyake, K; Ogino, H; Shimoyama, R; Watanabe, K, 2014) |
"Backround: Most solid cancers including colon cancer are believed to be initiated from and maintained by cancer stem cells (CSCs), that are responsible for treatment resistance, resulting in tumor relapse." | ( Batsaikhan, BE; Iwata, T; Kashihara, H; Kurita, N; Shimada, M; Takasu, C; Yoshikawa, K, 2014) |
"We genotyped 2886 stage III colon cancer patients treated adjuvantly in a randomized phase III trial with FOLFOX or FOLFIRI, alone or combined with cetuximab, and tested the individual associations between functionally deleterious DPYD variants and toxicity." | ( Alberts, SR; Berenberg, JL; Diasio, RB; Goldberg, RM; Lee, AM; Pavey, E; Sargent, DJ; Shi, Q; Sinicrope, FA, 2014) |
"The current treatment for colon cancer is more modest than had been hoped." | ( He, BC; Huang, J; Jin, JL; Sun, WJ; Wan, LH; Wang, DX; Wu, K; Wu, QX; Yang, JQ; Yuan, SX; Zhou, M, 2015) |
"To compare XELOX and FOLFOX4 as colon cancer adjuvant chemotherapy based on MOSAIC and No." | ( Du, ZD; He, XF; Li, Q; Tang, RL; Wen, F; Yao, K; Zhang, PF, 2014) |
"The human colon cancer SW620 cell line was pre-treated with the TLR4 inhibitor CRX-526 and stimulated with LPS." | ( Cao, CB; Huang, HY; Liu, FF; Peng, JQ; Qian, J; Ren, XJ; Wang, N; Zhang, ZJ, 2014) |
"We describe the case of a colon cancer patient who underwent adjuvant treatment with capecitabine and oxaliplatin and was admitted to the hospital with seizures and brain edema." | ( Fennig, S; Greenberg, G; Leshem, Y; Talianski, E; Wolf, I, 2014) |
"Human Caco-2 colon cancer cells were treated with DMEM (control), growth media alone (LB, TSB, MRS, and M17) or EcN SNs derived from these 4 media, in the presence and absence of 5-FU." | ( Bastian, SE; Howarth, GS; Lawrence, A; Wang, H, 2015) |
"Finally, using a human colon cancer xenograft murine model, we found that the combined 5-FU and 10058-F4 treatment significantly decreased tumorigenicity in nude mice compared with 5-FU or 10058-F4 treatment alone." | ( Enoki, T; Hamano, K; Hosoyama, T; Kugimiya, N; Li, TS; Nishimoto, A; Ueno, K, 2015) |
"Mice implanted with the human colon cancer cell line HT29 were administered 5-ALA and subsequently X-ray irradiated." | ( Fujiwara, H; Harada, K; Ichikawa, D; Ikoma, H; Kamada, Y; Komatsu, S; Kondo, Y; Konishi, H; Kuriu, Y; Morimura, R; Murayama, Y; Nakanishi, M; Nishimura, M; Okamoto, K; Otsuji, E; Sakakura, C; Shiozaki, A, 2014) |
"Nude mice bearing flank HT29 colon cancer xenografts were then treated daily with either bumetanide or saline for a total of 3 weeks." | ( Haaga, J; Jin, E; Lu, ZR; Malamas, AS; Zhang, Q, 2015) |
"Moreover, the mice subcutaneous CT26 colon cancer model was established to evaluate the therapy efficiency of Qu-M in detail, in which enhanced anti-colon cancer effect was proved in vivo: Qu-M were more efficacious in repressing the growth of colon tumor than free quercetin." | ( Gao, X; Gong, D; Gou, H; Huang, N; Ren, L; Shi, H; Xu, G, 2015) |
"Chemoresistance of colon cancer cells to the chemotherapeutics is still a main obstacle in treatment of this malignancy." | ( Chai, J; Dong, W; Guo, HL; Han, DL; Wang, L; Wang, S; Xie, C; Zhang, ZL, 2015) |
"For mechanistic studies, colon cancer cell lines HCT116 and HT29 were treated with triptolide and the effect on viability, caspase activation, annexin positivity, lactate dehydrogenase release, and cell cycle progression was evaluated." | ( Banerjee, S; Beyer, G; Chugh, R; Dawra, R; Dudeja, V; Li, L; Majumder, K; Oliveira, A; Saluja, A; Sangwan, V; Skube, SJ; Subramanian, S, 2015) |
"Their prognostic impact on colon cancer patients receiving adjuvant chemotherapy has not been well established." | ( Chang, WC; Chen, CW; Fan, YC; Hsu, WH; Huang, CW; Lou, YT; Lu, CY; Wang, JY; Wu, IC, 2014) |
"129 UICC stage III colon cancer patients who had received radical resection and FOLFOX adjuvant chemotherapy were enrolled." | ( Chang, WC; Chen, CW; Fan, YC; Hsu, WH; Huang, CW; Lou, YT; Lu, CY; Wang, JY; Wu, IC, 2014) |
"Neoadjuvant chemotherapy in colon cancer is feasible and the results suggest that a major part of the patients can be spared adjuvant chemotherapy." | ( Andersen, F; Fischer, A; Jakobsen, A; Jensen, LH; Jørgensen, JC; Larsen, O; Lindebjerg, J; Pløen, J; Rafaelsen, SR; Vilandt, J, 2015) |
"We administered chemotherapy for colon cancer using 5-fluorouracil plus Leucovorin(5-FU/LV), after which the CPK levels gradually decreased." | ( Ito, T; Kawamoto, Y; Okabe, M; Tsukumo, Y; Uchida, Y, 2015) |
"We treated the human colon cancer cell lines LiM6 and DLD1 with the NK1R antagonist and the clinical drug aprepitant (AP) and analyzed both growth response and downstream mechanisms using MTT-assay, reverse phase protein array (RPPA), western blot, Super TOP/FOP, confocal microscopy, and sphere formation ability (SFA) assays." | ( Alt, E; Berger, M; Garnier, A; Hubertus, J; Ilmer, M; Kappler, R; von Schweinitz, D; Vykoukal, J, 2015) |
"Stage III colon cancer is currently treated as an entity with a unified therapeutic principle." | ( Deng, G; He, J; Ma, J; Pei, H; Shen, H; Wu, X; Zeng, S; Zhang, S; Zhang, Y, 2015) |
"There were 1 colon cancer patient, 1 retroperitoneal liposarcoma, 1 renal oncocytoma, 3 Kaposi sarcoma patients treated with cyclosporine; in those treated with Tac there were 1 basal cell carcinoma, 1 Kaposi sarcoma, 2 thyroid carcinoma, 1 breast carcinoma, 1 bladder carcinoma, 1 renal cell carcinoma, and 1 colon carcinoma patients." | ( Ata, P; Demir, T; Eriş, C; Gökçe, AM; Kara, M; Özdemir, E; Ozel, L; Titiz, MI, 2015) |
"When SW 620 and HCT 116 human colon cancer cells were treated with 5µM 5Z-7-oxozeaenol, cell viability, growth, and clonogenic survival were significantly decreased." | ( Button, AM; Domann, FE; Fath, MA; Hrabe, JE; Mezhir, JJ; O'Leary, BR; Rodman, SN; Spitz, DR, 2015) |
"In human colon cancers, it is not fully examined the role of ABCG2 in porphyrin-based photodynamic therapy." | ( Choi, MG; Hasan, T; Kim, IW; Kim, JH; Park, JM; Roh, YJ, 2015) |
"We examined stage III colon cancer patients ages 65+ years initiating chemotherapy between 2003 and 2008 using US population-based cancer registry data linked with Medicare claims (N = 3,660)." | ( Brookhart, MA; Carpenter, WR; Glynn, RJ; Mack, CD; Meyer, AM; Sandler, RS; Stürmer, T, 2015) |
"In vitro CRTC1 loss of function in colon cancer cell lines was associated with reduced viability and cell division rate as well as enhanced chemotherapy-induced apoptosis on PGE2 treatment." | ( Aparicio, T; Baraille, F; Dentin, R; Guilmeau, S; Martin, A; Ourabah, S; Postic, C; Schumacher, Y; Wind, P, 2016) |
"The therapy of colon cancer (Cca) is poor currently." | ( Lan, B; Li, W; Lu, D; Zhang, J, 2016) |
"A major issue in colon cancer treatment is drug-resistance and metastasis that have been ascribed to the cancer stem cells." | ( Chen, J; Gu, W; Li, F; Liu, JP; Monteiro, M; Shao, R; Xu, ZP, 2015) |
"Patients with confirmed metastatic colon cancer treated at the Peking University Cancer Hospital between 2003 and 2012 were reviewed retrospectively." | ( Du, CZ; Gu, J; Li, ZM; Peng, YF, 2016) |
"It could be a good adjuvant for colon cancer patients during the course of chemotherapy." | ( Chao, Y; Chaojie, W; Hongxiang, L; Junmin, S; Zhen, L, 2015) |
"As a subset of colon cancer patients does not benefit from adjuvant chemotherapy, predictive biomarkers are desirable." | ( Benner, A; Bläker, H; Brenner, H; Burwinkel, B; Chang-Claude, J; Herpel, E; Hoffmeister, M; Jansen, L; Pfütze, K; Ulrich, A; Ulrich, CM; Yang, R, 2015) |
"Here we examine the effect of wheat on colon cancer risk in early and late postinitiation stages in carcinogen-treated rats." | ( Gallaher, DD; Islam, A, 2015) |
"Here, we report that treatment of colon cancer cell with 5-FU selects for cells with mesenchymal stem-like properties that undergo a metabolic reprogramming resulting in addiction to OXPHOS to meet energy demands." | ( Calvani, M; Caselli, A; Chiarugi, P; Cirri, P; Denise, C; Giannoni, E; Kazmi, SM; Kopetz, S; Landriscina, M; Paoli, P; Pettazzoni, P; Pia, MM; Sacco, E; Taddei, ML; Vanoni, M, 2015) |
"Here, human colon cancer cells, HCT116 with wild-type, heterozygous and a functionally null p53, were treated by radiation and SN38." | ( Bisgin, A; Helmfors, L; Meng, WJ; Nandy, SK; Pathak, S; Ping, J; Sun, XF; Waldmann, P, 2015) |
"S1P administration protected colon cancer cells from luteolin-induced apoptosis, most likely by an intracellular, receptor-independent mechanism." | ( Abdel Hadi, L; Di Vito, C; Ferraretto, A; Marfia, G; Riboni, L; Tringali, C; Viani, P, 2015) |
"We used gastric and colon cancer cell lines to study the synergistic effect of As4S4 in combination with BRD4 inhibitor JQ1, or with chemotherapy drug cisplatin and irinotecan or with COX2 inhibitor celecoxib." | ( Chen, S; Pan, M; Tong, Y; Zhang, L; Zhang, X, 2015) |
"The standard therapy for colon cancer is 5-FU-based regimen, although the current response rate to 5-FU is only 10-15%." | ( Chen, J; Han, M; Saif, MW, 2016) |
"The combination treatment of colon cancer with endostatin and a chemotherapeutic agent, cyclophosphamide proves to be an efficient therapeutic strategy to inhibit the rapid vasculature formation confirmed by the differential expression of notch signaling components." | ( Hu, TY; Lv, JY; Wang, G; Wang, RY; Zhu, JM, 2016) |
"To evaluate the impact of the 12-gene Colon Cancer Recurrence Score Assay-a clinically validated prognosticator in stage II colon cancer after surgical resection-on adjuvant treatment decisions in T3 mismatch repair proficient (MMR-P) stage II colon cancer in clinical practice." | ( Beny, A; Brenner, B; Chao, C; Dror, Y; Geva, R; Gluzman, A; Hubert, A; Idelevich, E; Liebermann, N; Man, S; Mishaeli, M; Purim, O; Rothney, M; Shacham-Shmueli, E; Shani, A; Shulman, K; Soussan-Gutman, L; Steiner, M; Tezcan, H, 2016) |
"The drug 5-FU is commonly used in colon cancer treatment and was used as a reference." | ( Adachi, N; Aoyama, H; Fujibayashi, Y; Furukawa, T; Saga, T; Wakizaka, H; Yoshii, Y; Zhang, MR, 2016) |
"BQC-G treatment of mice bearing human colon cancer xenografts with naturally or artificially elevated beta-glucuronidase activity produced significant antitumor activity, showing that BQC-G is a potent prodrug suitable for selective intratumoral drug activation." | ( Burnouf, PA; Chen, KC; Cheng, TL; Chou, HC; Huang, PT; Leu, YL; Prijovich, ZM; Roffler, SR, 2016) |
"Deficient mismatch repair (dMMR) colon cancer (CC) is reportedly resistant to 5-fluorouracil (5FU) adjuvant chemotherapy while preliminary data suggest chemosensitivity to oxaliplatin." | ( Aparicio, T; Artru, P; Bonnetain, F; Boussaha, T; Cauchin, E; Coriat, R; Des Guetz, G; Ferru, A; Karayan-Tapon, L; Lécaille, C; Lecomte, T; Matysiak-Budnik, T; Michel, P; Mouillet, G; Pagès, JC; Sefrioui, D; Sickersen, G; Silvain, C; Taïeb, J; Tougeron, D; Trouilloud, I; Vernerey, D; Zaanan, A, 2016) |
"Stem cell-like colon cancer cells (SCCs) pose a major challenge in colon cancer treatment because of their resistance to chemotherapy and radiotherapy." | ( Bang, SY; Heo, J; Jeong, SN; Kang, DH; Yoo, SY, 2016) |
"A total of 60 colon cancer patients and 60 patients with benign colorectal disease who received surgical treatment in our hospital from January 2009 to June 2010 were selected as observation group and control group respectively." | ( Qi, Y; Ren, H; Wang, W; Xu, Q, 2016) |
"L-Ascorbic acid treatment of human colon cancer cells that express a mutant KRAS differentially and synergistically induced cell death with cetuximab in a SVCT-2-dependent manner." | ( Gong, EY; Hong, SW; Hong, YS; Hwang, IY; Jin, DH; Jung, SA; Kim, JE; Kim, JH; Kim, KP; Kim, SM; Kim, T; Lee, DH; Lee, EY; Lee, JS; Lee, S; Lee, WJ; Moon, JH; Shin, JS; Shin, YJ, 2016) |
"Irinotecan resistant (CPT-11-R) LoVo colon cancer cell line was previous constructed by step-wise CPT-11 challenges to un-treated parental LoVo cells and expresses EGFR/IKKα/β/NF-κB pathway." | ( Chen, MC; Chen, RJ; Ho, TJ; Hsu, HH; Huang, CY; Kuo, WW; Lee, NH; Lin, YM; Tu, CC; Viswanadha, VP, 2017) |
"Patients with colon cancer in stage III who received adjuvant chemotherapy had a better overall survival." | ( Bellolio, F; Garrido, M; Leal, JL; Mondaca, S; Nervi, B; Padilla, O; Palma, S; Villalón, C; Zúñiga, Á, 2016) |
"All stage III colon cancer patients aged ≥70 years diagnosed in the southeastern part between 2005 and 2012 and treated with CAPOX or CapMono were included." | ( Creemers, GJ; Janssen-Heijnen, ML; Lemmens, VE; Maas, HA; Pruijt, JF; Razenberg, LG; van Erning, FN, 2016) |
"Patients diagnosed with stage II or III colon cancer from 2008 to 2012 and who received at least two cycle of adjuvant capecitabine were reviewed for treatment delays." | ( Amlani, A; Cheung, WY; Kumar, A; Ruan, JY, 2016) |
"This implies that treating colon cancer patients with TGFβ inhibitors may result in a worse outcome by enhancing inflammatory responses." | ( Bauer, J; Dawson, DW; DeCant, B; Diaz, AM; Grippo, PJ; Jung, B; Khazaie, K; Mangan, RJ; Mascariñas, E; McKinney, RD; Munshi, HG; Pasche, B; Principe, DR; Staudacher, J; Vitello, D; Wayne, EA, 2017) |
"CXCL12 treatment activated colon cancer cell EGFR signals, and CXCR4 or ADAM17 blockade reduced this activation." | ( Adhikari, S; Ayaloglu-Butun, F; Bissonnette, M; Dougherty, U; Fichera, A; Fletcher, M; Haider, HI; Hart, J; Joseph, L; Khalil, A; Konda, V; Li, YC; Meckel, K; Mustafi, D; Mustafi, R; Pekow, J; Sadiq, F, 2017) |
"In a murine orthotopic colon cancer model, oral administration of SMA-PTX micelles at doses 30 mg/kg and 60 mg/kg reduced tumor weight by 54% and 69%, respectively, as compared to the control group, while no significant reduction in tumor weight was observed with 30 mg/kg of PTX (Ebewe)." | ( Greish, K; Highton, AJ; Kemp, RA; Nehoff, H; Norton, SE; Parayath, NN; Taurin, S, 2016) |
"The treatment of splenic flexural colon cancer is not standardized because the lymphatic drainage is variable." | ( Ishibe, A; Masui, H; Nagahori, K; Ota, M; Suwa, Y; Watanabe, J, 2017) |
"This approach was applied to colon cancer collection, from an adjuvant treatment randomized study." | ( Edler, D; Egevad, L; Glimelius, B; Hrynchyk, I; Karlberg, M; Mezheyeuski, A; Östman, A; Portyanko, A; Ragnhammar, P, 2016) |
"In patients with stage III colon cancer treated with adjuvant FOLFOX, pT4 and pN2 was associated with reduced survival, but MSI status alone did not affect survival." | ( Hong, YS; Kim, CW; Kim, HJ; Kim, JC; Kim, JE; Kim, JH; Kim, KP; Kim, SY; Kim, TW; Lim, SB; Park, IJ; Yoon, YS; Yu, CS, 2017) |
"Patients with resected stage III colon cancers were randomized to adjuvant FOLFOX (folinic acid [leucovorin calcium], fluorouracil, and oxaliplatin) chemotherapy with or without cetuximab (North Central Cancer Treatment Group N0147 trial) or adjuvant FOLFOX chemotherapy with or without bevacizumab (National Surgical Adjuvant Breast and Bowel Project C-08 trial)." | ( Alberts, SR; Allegra, CJ; Goldberg, RM; Meyers, JP; Pogue-Geile, KL; Sargent, DJ; Shi, Q; Sinicrope, FA; Smyrk, TC; Thibodeau, SN; Yothers, G, 2017) |
"As GRM3 is upregulated in colon cancer, but rarely expressed in normal peripheral tissues, targeting GRM3 with such agents would not likely cause adverse neurological or peripheral side effects, making GRM3 an attractive and specific molecular target for colon cancer treatment." | ( Berim, L; Black, A; Geng, L; Talmon, G; Wang, J; Yi, H, 2017) |
"The diagnosis and treatment for colon cancer have been greatly developed, but the prognosis remains unsatisfactory." | ( Chen, QZ; He, BC; He, F; Hu, XL; Huang, M; Li, Y; Liu, RX; Ren, WY; Shao, Y; Sun, WJ; Wu, K; Zeng, YH; Zhou, LY, 2017) |
"Records of patients with stage III colon cancer who underwent curative surgery and adjuvant chemotherapy from April 2007 and September 2014 were retrospectively reviewed." | ( Hara, K; Ishii, T; Kondo, H; Shimizu, H; Suzuki, A; Takemoto, K; Tashiro, J; Yamaguchi, S, 2017) |
"A total of 258 patients with stage III colon cancer received oral adjuvant chemotherapy with UFT/LV (n = 157, 61%) and CAPE (n = 101, 39%)." | ( Hara, K; Ishii, T; Kondo, H; Shimizu, H; Suzuki, A; Takemoto, K; Tashiro, J; Yamaguchi, S, 2017) |
"Patients with locally advanced colon cancer (LACC) have a relatively poor prognosis despite radical resection and adjuvant chemotherapy." | ( Huang, CJ; Huang, CM; Huang, CW; Huang, MY; Ma, CJ; Tsai, HL; Wang, JY; Yeh, Y-, 2017) |
"The study was performed on human colon cancer cell lines COLO 205, HT-29 and 3C-P treated with ACD and IFN in subtoxic concentrations." | ( Bezdenezhnykh, N; Kocherga, R; Kovalova, O; Kudryavets, Y; Lykhova, O; Maksimyak, GI; Vorontsova, A; Zhylchuk, V, 2017) |
"Different strategies against colon cancer are accompanied by treatment failure, because of drug toxicity toward normal cells and cancer stem cells (CSCs) resistance." | ( Abu-Serie, MM; El-Rashidy, FH, 2017) |
"GRP78 expression was suppressed in LoVo colon cancer cells by utilizing small-interfering RNA (si-GRP78), and the cells were subsequently used to study the antiproliferative and anticancer effects of 5-FU treatment." | ( Han, YS; Kim, S; Lee, JH; Lee, SH; Yun, S, 2017) |
"Human colon cancer SW480 cells were transfected with CDH17 interference vector and treatment with 10 µmol/L noscapine." | ( Cai, Y; Chen, W; Han, Z; Huang, X; Liu, M; Liu, W; Tan, J; Tian, X; Wang, Y; Zhu, Q; Zou, Y, 2017) |
"Two hundred thirty-one patients with colon cancers who underwent curative surgery and FOLFOX adjuvant chemotherapy between November 2005 and December 2011 were included." | ( Kim, YB; Noh, OK; Oh, SY; Suh, KW, 2017) |
"The 5-year DFS rate was lower in colon cancer patients with low lymphocyte count during chemotherapy (61." | ( Kim, YB; Noh, OK; Oh, SY; Suh, KW, 2017) |
"Restoring oxygen in metastatic colon cancer through ITPP inhibits tumor spread and markedly improves animal survival; an effect that is enhanced through the application of subsequent chemotherapy." | ( Clavien, PA; Graf, R; Humar, B; Kachaylo, E; Kron, P; Lehn, JM; Limani, P; Linecker, M; Nicolau, C; Schneider, MA; Tschuor, C; Ungethuem, U, 2017) |
"A patient with colon cancer was treated with CapeOx (oxaliplatin 200mg, day 1; capecitabine 1." | ( Fang, W; Fu, Y; Wei, J, 2018) |
"This study included 65 patients with colon cancer treated with neoadjuvant chemotherapy in a phase II trial." | ( Hansen, TF; Jakobsen, A; Jensen, LH; Kjær-Frifeldt, S; Lindebjerg, J; Rafaelsen, SR; Sørensen, FB, 2018) |
"Among 2636 patients with stage III colon cancer treated with FOLFOX, MMR status was available for 2501." | ( Alberts, SR; Folprecht, G; Goldberg, RM; Julie, C; Laurent-Puig, P; Le Malicot, K; Meyers, JP; Mini, E; Sargent, DJ; Shi, Q; Sinicrope, FA; Smyrk, TC; Tabernero, J; Taieb, J; Van Laethem, JL; Zaanan, A; Zawadi, A, 2018) |
"With regards to colon cancer, resistance to 5‑fluorouracil (5‑FU)‑based chemotherapy and cancer stem cells (CSCs) are considered important factors underlying therapy failure." | ( Cai, H; Du, B; Feng, S; Hu, Y; Ma, W; Miao, G; Wang, J; Wang, W; Zhang, L, 2017) |
"In a colon cancer mouse model, we demonstrate that the combination of computed tomography imaging and gold nanoparticles conjugated to αPDL1 allowed prediction of therapeutic response, as early as 48 h after treatment." | ( Cohen, CJ; Meir, R; Motiei, M; Popovtzer, R; Sadan, T; Shamalov, K; Yaari, G, 2017) |
"CTD treatment of mice implanted with colon cancer cells showed tumor growth inhibition and reduced TrxR1 activity and ROS level." | ( Bao, M; Chen, R; Dai, X; Dong, X; Liang, G; Shen, X; Sun, X; Vladimir, K; Zhuge, W; Zia, K, 2018) |
"In Wnt-activated colon cancer cells, knockout of either PAD2 or β-catenin substantially increased resistance to NTZ treatment." | ( Brokstad, KA; Cheng, PF; Hoffman, PS; Kalland, KH; Ke, X; Levesque, MP; Olsen, JR; Oyan, AM; Qu, Y; Yuan, X; Zhang, W, 2018) |
"In the present study, five human colon cancer cell lines were directly treated with a calpain-2 inhibitor and results showed increased cell death in 4 of 5 cell lines and decreased anchorage-independent growth for all cell five lines." | ( Bertino, P; Hashimoto, AS; Hoffmann, FW; Hoffmann, PR; Horio, DT; Marciel, MP; Martinez, V; Rose, AH, 2018) |
"We enrolled 26 consecutive colon cancer patients, who had undergone surgical treatment." | ( Aoki, J; Ikeda, H; Kurano, M; Nishikawa, T; Saigusa, D; Sato, M; Uranbileg, B; Watanabe, T; Yatomi, Y, 2018) |
"Human colon cancer HT-29 cells were treated with curcumin (2." | ( Hoffman, RM; Qiu, J; Song, Y; Sun, YU; Tang, J; Tao, Y; Wang, D; Wang, H; Wang, X; Yang, G; Yang, Z, 2018) |
"Emerging treatment options for colon cancer are needed to overcome the limitations regarding the side effects of current chemotherapeutics and drug resistance." | ( Banciu, M; Licarete, E; Luput, L; Patras, L; Porfire, A; Rauca, V; Sesarman, A; Sylvester, B; Tefas, L, 2018) |
"As adjuvant chemotherapy for stage III colon cancer, mFOLFOX6/XELOX regimens are acceptable." | ( Ishibashi, K; Ishida, H; Kato, H; Kato, R; Koda, K; Kosugi, C; Mori, M; Narushima, K; Oya, M; Shuto, K; Tanaka, S; Yoshimatsu, K, 2018) |
"We used two human colon cancer cell lines SW480 and SW620 of different malignancies which were treated with a sublethal PDT protocol." | ( Czuba, Z; Kawczyk-Krupka, A; Krammer, B; Latos, W; Sieroń, A; Verwanger, T; Wasilewska, K, 2018) |
"LXR agonist-treated-colon cancer cells exhibited translocation of calreticulin (CRT) and release of HMGB1 and ATP into the medium." | ( Chen, K; Feng, F; Ju, X; Ren, M; Wang, Q, 2018) |
"Among patients with stage III colon cancer receiving adjuvant therapy with FOLFOX or CAPOX, noninferiority of 3 months of therapy, as compared with 6 months, was not confirmed in the overall population." | ( Andre, T; Boukovinas, I; Grothey, A; Iveson, T; Kerr, R; Labianca, R; Meyerhardt, JA; Meyers, JP; Niedzwiecki, D; Paul, J; Renfro, LA; Sargent, DJ; Saunders, M; Shi, Q; Shields, AF; Sobrero, AF; Souglakos, J; Taieb, J; Torri, V; Vernerey, D; Watanabe, T; Yamanaka, T; Yoshino, T, 2018) |
"JQ-1 was used to treat SW480 colon cancer mouse xenografts." | ( Liu, C; Song, H; Tian, S; Xiong, J; Zhang, Y; Zhou, Y, 2018) |
"Using colon cancer cells, ICG uptake and anti-tumor effects were examined between the treatments of ICG and sCA-ICG." | ( Doki, Y; Haraguchi, N; Hata, T; Inoue, A; Matsuda, C; Miyoshi, N; Mizushima, T; Mori, M; Nishimura, J; Ota, M; Takahashi, H; Tamai, K; Wu, X; Yamamoto, H; Yokoyama, Y, 2018) |
"To explore a role of neem in CRC, human colon cancer cell lines HCT116 and HT29 cells were treated with purified Super Critical Neem Extract (SCNE) or the neem liminoid, nimbolide." | ( Cabang, AB; Morris, J; Mukhopadhyay, KD; Patel, MJ; Tripathy, S; Wangjam, T; Wargovich, MJ, 2018) |
"Patients with metastatic colon cancer can be treated with alternating courses of FOLFOX6 and FOLFIRI in order to reduce their adverse events." | ( Ohara, H; Yamamoto, H, 2018) |
"When human colon cancer HCT116, CX-1, and LS174T cells were treated with ferroptotic agents such as sorafenib (SRF), erastin, and artesunate, data from immunoblot assay showed that ferroptotic agents induced endoplasmic reticulum (ER) stress and the ER stress response-mediated expression of death receptor 5 (DR5), but not death receptor 4." | ( Bartlett, DL; Choudry, HA; Jeong, SY; Lee, DH; Lee, YJ; Lee, YS; Oh, SC; Park, SH; Park, YS; Yu, J, 2019) |
"Although it is well established that colon cancer is one of the many gastrointestinal manifestations associated with systemic lupus erythematous, the diagnosis and treatment remains complex due to adrenal insufficiency symptoms." | ( Chang, Q; Chen, Y; Fei, J; Shen, L; Shi, J; Wan, B; Yi, Q, 2018) |
"Intensive study on pathogenesis of colon cancer has been made to decipher the mechanisms underlying the development and progress of the disease so as to develop effective treatment." | ( Iqbal, Z; Mishra, H; Mishra, PK; Siddiqui, L; Talegaonkar, S, 2018) |
"Human colon cancer cells and human melanoma cells were cultured and then treated with 1 mM bupivacaine or levobupivacaine for up to 24 or 48 h." | ( Chen, L; Han, C; Hirota, K; Li, T; Ma, D; Masters, J; Wu, L; Zhao, H, 2019) |
"Targeted drug delivery to colon cancer cells can significantly improve the efficiency of treatment." | ( Li, X; Liu, W; Liu, X; Pan, W; Pang, J; Wang, F; Zhu, Y, 2018) |
"Gastric and colon cancers have been the leading causes of cancer mortality in the world with limited therapy." | ( Chen, S; Kang, T; Tan, Z; Zhang, L; Zhang, X, 2018) |
"After curative resection of stage II colon cancer, adjuvant chemotherapy with 5-fluorouracil/leucovorin (FL) or capecitabine is selectively recommended." | ( Cho, S; Jeong, SY; Kim, MJ; Kwon, YH; Lee, KY; Park, JW; Park, KJ; Ryoo, SB, 2019) |
"Human HT-29 colon cancer cell-line was used for in vitro assays and in vivo studies were performed in Wistar rats to assess the usefulness and effectiveness of the formulation for colon cancer therapy." | ( Asnani, GP; Kokare, CR, 2018) |
"In conclusion, miR-214 sensitizes colon cancer cells to 5-FU by targeting Hsp27, indicating a significant role for this miRNA in colon cancer chemotherapy." | ( Bao, Y; Du, LJ; Ma, ZH; Wan, J; Yang, GK; Yang, Y, 2019) |
"Although colon cancer is one of the most important triggers of cancer related mortality, a few therapeutic options exist for this disease, including combination chemotherapy, anti-EGFR and anti-angiogenic agents." | ( Azizi, G; Ghalamfarsa, G; Hojjat-Farsangi, M; Jadidi-Niaragh, F; Karpisheh, V; Namdar, A; Nikkhoo, A; Sabz, G; Yousefi, B; Yousefi, M, 2019) |
"In pursuit of a novel approach in colon cancer therapy, we explored the ability of ruthenium baicalein complex to eradicate colon cancer by efficiently targeting various apoptotic pathways on human colon cancer cell line and on a DMH and DSS induced murine model of colorectal cancer." | ( Bian, L; Chakraborty, T; Chanda, P; Ghosh, T; Roy, S; Wang, Y, 2019) |
"Patients with stage III colon cancer homogeneously treated with surgery followed by FOLFOX chemotherapy between Jan 2007 and Aug 2013 were included retrospectively." | ( Baik, SH; Cha, YJ; Kang, J; Lee, KY; Park, EJ, 2019) |
"Globally, colon cancer is a predominant cause of increased morbidity and mortality annually; therefore, in addition to traditional treatments, new protocols are under continuous investigation." | ( Alnaggar, M; Chen, Y; Xiao, H, 2019) |
"Forty PDOX mouse models with colon cancer growing on the peritoneum were divided into 4 groups of 10 mice each by measuring the tumor size and fluorescence intensity: untreated control; 5-fluorouracil (5-FU) (50 mg/kg, once a week for two weeks, ip) and oxaliplatinum (OXA) (6 mg/kg, once a week for two weeks, ip); o-rMETase (100 units/day, oral 14 consecutive days); combination 5-FU + OXA and o-rMETase." | ( Bouvet, M; Clary, B; Han, Q; Higuchi, T; Hoffman, RM; Park, JH; Singh, SR; Sugisawa, N; Tan, Y; Yamamoto, J; Yoon, SN; Zhao, M, 2019) |
"Anthos and ExoAnthos treatment of colon cancer cells showed dose-dependent decreases in cell viability." | ( Egilmez, NK; Gu, T; Gupta, RC; Jeyabalan, J; Mudd, AM; Munagala, R, 2020) |
"CEA in patients with colon cancer, which express SGLT2 but not UGT1A9, and type 2 diabetes mellitus was treated by dapagliflozin alone after radiation therapy was decreased but started to rise after cessation of dapagliflozin (case 2)." | ( Nakajima, Y; Okada, J; Okada, S; Osaki, A; Ozawa, A; Pessin, JE; Saito, T; Shimoda, Y; Yamada, E; Yamada, M; Yokoo, H, 2020) |
"In comparison with the control, both colon cancer and treated groups showed invasion of the colonic tissue by pleomorphic branching colonic glands of variable shapes and sizes lined with dysplastic elongated hyperchromatic nuclei with frequent mitotic figures or stratified multi-layered crowded nuclei with an extremely significant (p < 0." | ( Abd El-Hady El-Safti, FE; Abdel-Rahman, SA; Badr El-Kholy, W; Mohey Issa, N, 2021) |
"However, colon cancer is difficult to treat due to its resistance to TRAIL." | ( Kim, B; Lee, KY; Park, B; Seo, JH, 2020) |
"Therefore, it is necessary to treat colon cancer and its thrombosis complications simultaneously." | ( Huang, M; Ji, Y; Li, T; Liu, M; Liu, Y; Lü, S; Qi, T; Yan, J; Zhang, SF, 2020) |
"Subcutaneous mouse models of colon cancer cell line LS174T were used to determine the optimal dose of administration and timing of imaging." | ( Amirfakhri, S; Bouvet, M; Filemoni, F; Hoffman, RM; Hollandsworth, HM; Molnar, J; Yazaki, PJ, 2020) |
"Treatment of colon cancer cells with α-methyltryptophan (α-MT), a blocker of SLC6A14, induces amino acid deprivation, decreases mTOR activity, increases autophagy, promotes apoptosis, and suppresses cell proliferation and invasion." | ( Bhutia, YD; Brown, TP; Ganapathy, V; Sikder, MOF; Sivaprakasam, S; Thangaraju, M, 2020) |
"Human colon cancer cell line SW480 was divided into a control group, 3 propofol treatment groups (with 2, 4 and 8 μg/mL propofol treatment, respectively), and a propofol+colivelin group." | ( Dong, T; Liang, B, 2020) |
"Early diagnosis and treatment of colon cancer is of great significance for cancer therapy." | ( Chen, M; Fang, L; Feng, HT; Lee, MH; Tang, BZ; Xiong, F; Zou, S, 2020) |
"Adjuvant treatment for stage II colon cancer remains debated." | ( André, T; Benhaim, L; Chauvenet, M; Emile, JF; Geillon, F; Laurent Puig, P; Le Malicot, K; Lepage, C; Manfredi, S; Taïeb, J; Taly, V; Tougeron, D, 2020) |
"The incidence of colon cancer increased worldwide in 2019 and its treatment is urgent from a quality of life perspective." | ( Baba, K; Kimura, Y; Kiyoi, T; Sumiyoshi, M, 2020) |
"Our analysis confirms that women with colon cancer receiving adjuvant fluoropyrimidine-based chemotherapy are at increased risk of toxicity." | ( Alberts, SR; Allegra, CJ; Andre, T; Blanke, CD; de Gramont, A; Dixon, JG; Francini, E; George, TJ; Goldberg, RM; Grothey, A; Haller, DG; Kerr, R; Marsoni, S; O'Connell, MJ; Saltz, LB; Seitz, JF; Shi, Q; Taieb, J; Twelves, C; VanCutsem, E; Wagner, AD; Wolmark, N; Yothers, G, 2021) |
"In stage III colon cancer, randomised clinical trials and meta-analyses of modulated 5-fluorouracil (5-FU) based chemotherapy versus surgery scored ESMO-MCBS grade A and randomised controlled trials (RCTs) and meta-analyses comprising oxaliplatin added to this 5-FU backbone showed a more modest additional overall survival benefit (grade A and B)." | ( Cherny, NI; Dafni, U; de Groot, DJ; de Vries, EGE; Douillard, JY; Knapen, DG; Latino, NJ; Zygoura, P, 2020) |
"Chemotherapy of colon cancer needs improvement to mitigate the severe adverse effects (AEs) associated with the cytotoxic drugs." | ( Duan, J; Li, X; Yang, XD; Yu, Z, 2020) |
"Rats chemically initiated for colon cancer were either non-treated or post-treated with highly saturated ASCex for 32 weeks after initiation, other groups of rats were administered ASCex without cancer initiation or served as normal controls." | ( Abdelhady, HA; El-Gamal, MM; Mona, MM; Salim, EI, 2020) |
"Indomethacin [IND] is reported to treat colon cancer." | ( Devaraj, H; Seetha, A; Sudhandiran, G, 2021) |
"The current treatment options for colon cancer patients include chemotherapy, surgery, radiotherapy, immunotherapy, and targeted therapy." | ( Beyzai, B; Edalati, M; Hojjat-Farsangi, M; Jadidi-Niaragh, F; Joshi, N; Karpisheh, V; Namdar, A; Zekiy, AO, 2020) |
"After simulation of colon cancer, the animals were intragastrically administered entorosorbent at a dose of 1 ml of suspension (corresponding to 0." | ( Fira, D; Fira, L; Kachur, O; Kramar, S; Lykhatskyi, P, 2020) |
"We report a case of transverse colon cancer with intestinal malrotation treated with laparoscopic surgery using the ICG fluorescence method." | ( Aoki, H; Arata, T; Katsuda, K; Kimura, Y; Nagahisa, S; Tanakaya, K; Taniguchi, F; Une, Y; Utsumi, M; Watanabe, M, 2020) |
"First, colon cancer cell lines (HCT116 and SW480 cells) were treated with different doses of TEC (0-200 μM)." | ( Gao, D; Guo, W; Qu, Y; Wang, J; Xiong, L; Yang, Y; Zhang, Y, 2021) |
"The survival of colon cancer cells was decreased, whereas the apoptosis of colon cancer cells was increased by PTX treatment in a dose-dependent manner." | ( Li, HX; Xiao, ZS; Yin, ZH; Zhang, XN; Zhao, L, 2021) |
"In this study, human colon cancer cells (COLO 225) were treated with gossypol." | ( Cao, F; Cao, H; Sethumadhavan, K; Wang, TTY, 2021) |
"In a CT26 mouse syngeneic colon cancer model, cachexia was predominantly induced by chemotherapy with 5-fluorouracil (5-FU) than by tumor growth." | ( Im, M; Kim, HJ; Kim, JK; Kim, JY; Kim, SJ; Kim, ST; Park, SK; Woo, CW; Woo, DC; Yoo, HJ, 2021) |
"Among patients with stage III colon cancer, the addition of celecoxib for 3 years, compared with placebo, to standard adjuvant chemotherapy did not significantly improve disease-free survival." | ( Bendell, JC; Bertagnolli, M; Blanke, C; Couture, F; Fuchs, CS; Goldberg, RM; Grothey, A; Guthrie, KA; Hochster, HS; Kuebler, P; Kumar, P; Kumthekar, P; Lewis, D; Meyer, J; Meyerhardt, JA; Niedzwiecki, D; O'Reilly, EM; Shi, Q; Shields, AF; Tan, B; Venook, A; Zemla, T, 2021) |
"Human colon cancer cell lines, proficient (HT29) and deficient (HCT116) in MMR, were treated with 5-FU and Olaparib." | ( Bencke Grudzinski, P; da Costa Ghignatti, PV; de Castro E Gloria, H; Guecheva, TN; Jesuíno Nogueira, L; Motta Leguisamo, N; Saffi, J, 2021) |
"The current colon cancer therapy mainly revolves around chemotherapy, radiotherapy and surgery, but the search continues for more effective interventions." | ( Albalawi, R; Khan, FA; Pottoo, FH, 2022) |
"In this study, one out of five colon cancer patients were hospitalized during adjuvant chemotherapy." | ( Abdel-Rahman, O; Koski, S; Tang, PA, 2021) |
"The LoVo colon cancer cell line forming spheroids, treated with crizotinib (CZB) an ATP-competitive small-molecule inhibitor of the receptor tyrosine kinases, was employed to study and assess the correlation between biophysical and morphological parameters in both live and fixed cells." | ( Bacchi, F; Bonetti, S; Cavallo, C; Filardo, G; Gazzola, D; Lauriola, M; Mazzeschi, M; Musmeci, F; Pasqua, S; Santi, S; Sargenti, A, 2021) |
"Traditionally, adjuvant treatment for colon cancer has been 6 months of combination chemotherapy." | ( Hanna, C; Iveson, P; Iveson, T; Levasseur, A; Meyerhardt, J; Zhang, S, 2021) |
"In this study, human colon cancer oxaliplatin-resistant cells were treated with oxaliplatin combined with the natural product erianin." | ( Cao, Y; Lei, M; Liu, J; Liu, S; Ma, X; Su, C, 2021) |
"Only 50-70% of elderly colon cancer patients could complete the recommended 6 months of postoperative chemotherapy." | ( Chen, J; Chen, W; Dong, H; Wang, G; Wang, W, 2021) |
"A total of 1217 surgery-treated colon cancer patients between August 1, 2013, and September 1, 2019, were reviewed, and 257 stage III and high-risk stage II patients aged ≥ 70 were enrolled." | ( Chen, J; Chen, W; Dong, H; Wang, G; Wang, W, 2021) |
"However, the treatment strategies for colon cancer remain unsatisfactory for patients, especially for those with advanced or recurrent colon cancer." | ( Bao, Y; Li, W; Li, Z; Wang, Y; Wang, Z; Zhou, X; Zhu, Z, 2021) |
"Herein, colon cancer targeting calcium phosphate nanoparticles were developed to carry PSVII to treat drug-resistant colon cancer." | ( Bai, S; Cheng, Y; Ji, Q; Jiang, C; Liu, D; Liu, M; Mei, Q; Sun, Y; Ye, W; Zhang, B; Zhou, S, 2021) |
"The main therapy for colon cancer with liver metastasis is chemotherapy based on 5-fluorouracil combined with targeted drugs." | ( Chen, S; Guo, S; Huang, Z; Li, J; Liu, Y; Wang, P; Wang, X; Yue, T; Zhu, J, 2022) |
"To evaluate PTX effects on colon cancer patients treated with chemotherapy." | ( Baider, L; Barak, V; Meirovitz, A; Peretz, T; Stephanos, S, 2021) |
"Forty metastatic colon cancer patients receiving chemotherapy were enrolled in this randomized study." | ( Baider, L; Barak, V; Meirovitz, A; Peretz, T; Stephanos, S, 2021) |
"PTX treatment of colon cancer patients, in addition to chemotherapy, significantly improved survival rates, induced weight gain and reduced stomatitis occurrence -all important parameters of cachexia." | ( Baider, L; Barak, V; Meirovitz, A; Peretz, T; Stephanos, S, 2021) |
"Cordycepin is able to suppress colon cancer cell proliferation, likely mediated by the MYC/miR-26a pathway, supporting its potential for the treatment of colon cancer." | ( Li, K; Liu, Y; Zhang, Z; Zheng, Z, 2022) |
"The drug resistance in the treatment of colon cancer is most reduced in patients carrying allele 10 and methylated in KCNQ1OT1 promoter." | ( Wang, Y; Zhang, C, 2022) |
"Current therapies for colon cancer are hindered by treatment failure and recurrence, mainly due to colon cancer stem cells (CSCs)." | ( Deng, T; Du, B; Fu, F; Qiu, F; Wang, Z; Xi, X; Zhu, Y, 2022) |
"Treatment of colon cancer cells with GZ17-6." | ( Booth, L; Dent, P; Von Hoff, D; West, C, 2022) |
"Apoptosis is de-regulated in colon cancer and is one key mechanism of cancer treatment." | ( Deng, YY; Fu, J; Pan, SL; Qin, XJ; Zhang, YH; Zhang, ZJ, 2022) |
"Since colon cancer stem cells (CSCs) play an important role in chemoresistance and in tumor recurrence and metastasis, targeting of CSCs has emerged as a sophisticated strategy for cancer therapy." | ( Ahn, YH; Fei, X; Jo, MK; Jung, SA; Kim, EJ; Kim, M; Kim, SE; Kim, TI; Kwon, JH; Moon, CM; Mun, YC; Seo, SY, 2022) |
"plantarum-12 could ameliorate the colon cancer symptoms of azoxymethane (AOM)/DSS-treated C57BL/6 mice." | ( Jiang, S; Ma, F; Mu, G; Qian, F; Song, Y; Sun, M; Tuo, Y; Wang, A, 2022) |
"In this study, we hypothesized that colon cancer cells with the stem cell feature of CD133 expression have increased proton leakage that influences glucose metabolism and offers protection against reactive oxygen species (ROS)-inducing treatment." | ( Cho, YS; Jung, KH; Kim, M; Lee, EJ; Lee, JH; Lee, KH; Park, JW, 2022) |
"Patients with stage II colon cancer were randomly assigned in a 2:1 ratio to have treatment decisions guided by either ctDNA results or standard clinicopathological features." | ( Burge, M; Cohen, JD; Day, F; Dobbyn, L; Gibbs, P; Harris, M; Harris, S; Hayes, T; Hruban, R; Khattak, A; Kinzler, KW; Kosmider, S; Lahouel, K; Lee, B; Lee, M; Lennon, AM; Lo, SN; Lynam, J; McLachlan, SA; Nott, L; Papadopoulos, N; Popoli, M; Ptak, J; Shapiro, J; Silliman, N; Tie, J; Tomasetti, C; Vogelstein, B; Wang, Y; Wong, R, 2022) |
"Patients with colon cancer who prematurely discontinue postoperative chemotherapy may have an increased risk of disease recurrence and death." | ( Brown, JC; Caan, BJ; Cespedes Feliciano, EM; Cheng, E; Meyerhardt, JA, 2022) |
"Among patients with stage II-III colon cancer who initiate postoperative chemotherapy, excess visceral and intramuscular adiposity may be risk factors for the premature discontinuation of chemotherapy." | ( Brown, JC; Caan, BJ; Cespedes Feliciano, EM; Cheng, E; Meyerhardt, JA, 2022) |
"Drug resistance of colon cancer cells is the key to affect the efficacy of colon cancer chemotherapy and lead to chemotherapy failure." | ( Chen, G; Huang, J; Wei, X; Yang, Z, 2022) |
"After simulation of colon cancer, the animals were intragastricly administered entorosorbent at a dose of 1 ml of suspension (corresponding to 0." | ( Fira, D; Fira, L; Garlitska, N; Kachur, O; Lykhatskyі, P, 2022) |
"Drug resistance in colon cancer is gradually affecting the treatment." | ( Chen, X; Guo, M; Li, B; Lin, C; Qiu, H, 2022) |
"Finally, we subdivided the colon cancer patients into four groups to explore combination immunotherapy." | ( Fang, D; Liu, H; Xu, J; Ye, J; Zhang, C; Zhao, S; Zhao, Z; Zhou, X, 2022) |
"Treatment with PTZ and TFP inhibited colon cancer cells growth in a dose-dependent manner." | ( Mohd Sani, MH; Muhamad Salih, FA; Palasuberniam, P; Suali, L; Sudi, S; Sunggip, C; Thomas, FM, 2022) |
"Current cancer treatment fails to treat colon cancer completely due to the remains of Cancer Stem Cells (CSCs)." | ( Agarwal, S; Gor, R; Karri, U; Madhavan, T; Pachaiappan, R; Ramalingam, S; Saha, L; Sohani, A, 2022) |
"The human colon cancer cell lines HCT-116 and Caco-2 were subjected to stimulation with interleukin-6 (IL-6) as well as tumor necrosis factor alpha (TNF-α), with subsequent treatment using the NF-κB pathway-specific inhibitor ammonium pyrrolidinedithiocarbamate (PDTC)." | ( Chen, XQ; Han, TT; Li, JN; Li, WB; Lv, K; Mao, JY; Wang, CS, 2022) |
"Of patients with colon cancer treated with an initial lower 5-FU dose, 18% had a therapeutic 5-FU blood level." | ( Baranseh, J; Khatib, AW; Selub, SM; Shai, A; Uryvaey, A, 2023) |
"15-PGDH inhibition increased colon cancer metastasis by inducing changes in EMT-related genes via an increase in PGE2 expression and could be a promising biomarker for anticancer treatment." | ( Bae, KB; Baik, H; Hur, DY; Kang, MS; Kim, SH; Song, SE, 2022) |
"Forty patients with metastatic colon cancer receiving chemotherapy, were randomized in this study." | ( Baider, L; Barak, V; Meirovitz, A; Peretz, T; Stephanos, S, 2022) |
"High malignancy and mortality in colon cancer require clarifying the underlying mechanisms of colon cancer carcinogenesis and exploring new targets or drugs for the clinical treatment of colon cancer." | ( Deng, Y; He, B; Luo, H; Qin, X; Yao, X; Zhang, J, 2022) |
"58 patients with stage II-III colon cancer treated with surgery and chemotherapy." | ( Berger, AM; Goldner, W; Hammer, MJ; Klute, K; Langenfeld, SJ; Rasmussen Mandolfo, N; Shade, MY; Struwe, LA, 2022) |
"58 patients with stage II-III colon cancer treated with surgery and chemotherapy." | ( Berger, AM; Goldner, W; Hammer, MJ; Klute, K; Langenfeld, SJ; Rasmussen Mandolfo, N; Shade, MY; Struwe, LA, 2022) |
"58 patients with stage II-III colon cancer treated with surgery and chemotherapy." | ( Berger, AM; Goldner, W; Hammer, MJ; Klute, K; Langenfeld, SJ; Rasmussen Mandolfo, N; Shade, MY; Struwe, LA, 2022) |
"Human colon cancer HCT116 cells were treated with different concentrations of β-elemene." | ( Chen, G; Deng, H; Zhang, J, 2023) |
"Human colon cancer HCT116 cells were treated with different concentrations of β-elemene." | ( Chen, G; Deng, H; Zhang, J, 2023) |
"The current colon cancer treatment strategies assure partial or even complete tumour regression but loco-regional relapse or distant metastasis is the major cause of death despite combination therapy." | ( Banerjee, R; Chilakamarthi, U; Giribabu, L; Koteshwar, D; Krishna, NV; Mahadik, NS, 2023) |
"The current colon cancer treatment strategies assure partial or even complete tumour regression but loco-regional relapse or distant metastasis is the major cause of death despite combination therapy." | ( Banerjee, R; Chilakamarthi, U; Giribabu, L; Koteshwar, D; Krishna, NV; Mahadik, NS, 2023) |
"Lipid metabolic reprogramming in colon cancer shows a potential impact on tumor immune microenvironment and is associated with response to immunotherapy." | ( Chao, D; Chen, H; Chen, X; He, N; Liu, L; Mo, M; Wang, Y; Yang, J; Yuan, X; Zhang, N; Zhang, Y, 2023) |
"Here, colonic cancer cells were cultured in the ECIS array before being treated with RA, and any changes in response to RA were monitored after treatment." | ( Bates, DO; Benest, AV; Marva, G; Ordóñez-Morán, P; Ünsal, S, 2023) |
"Mouse colon cancer cells(CT26) were transplanted into the mice except for those in the normal group to construct the tumor-bearing mouse model by subcutaneous injection, and 5-FU chemotherapy and BSP treatment were carried out from the second day of modeling." | ( Cui, YR; He, TH; Liu, P; Wang, WL; Xie, XX; Yu, J; Zhang, JT, 2023) |
"Accurate staging of colon cancer is imperative in directing treatment and prognostication." | ( Gao, Y; Gauci, CM; Kim, TJ; Perera, DS, 2023) |
"For patients with resected stage III colon cancer, 6 months of adjuvant fluoropyrimidine-based chemotherapy has been the standard of care." | ( Ahn, DH; Alese, OB; Bekaii-Saab, TS; Draper, A; Griswold, CR; Kang, S; Larson, JJ; Ou, FS; Patel, B; Raman, P; Sonbol, MB; Ueberroth, BE; Walden, DJ; Wu, CS, 2023) |
"A total of 399 patients with stage III colon cancer who received adjuvant chemotherapy were included in the analysis." | ( Ahn, DH; Alese, OB; Bekaii-Saab, TS; Draper, A; Griswold, CR; Kang, S; Larson, JJ; Ou, FS; Patel, B; Raman, P; Sonbol, MB; Ueberroth, BE; Walden, DJ; Wu, CS, 2023) |
"In vitro studies using colon cancer cell lines showed that RC48 effectively impeded the proliferation of HER2-positive cells, indicating its potential as a treatment for HER2-positive colon cancer." | ( Gu, Y; Guo, W; Han, X; Li, X; Liu, W; Wang, W; Wu, X; Xu, L; Xu, Q; Zhang, W; Zhou, Y, 2023) |
"Treatment options for advanced colon cancer are mainly combinations of chemotherapy and targeted drugs." | ( Guo, Y; Liu, F; Nian, J; Xu, Y; Yang, G, 2023) |
"Treating colon cancer cells with a DNA methyltransferase inhibitor, 5-aza-2'-deoxycytidine (DAC), led to elevated expression levels of CYP1B1 and CYP3A4 through demethylation of the promoter regions of related genes." | ( Ozawa, S, 2023) |