Postural Orthostatic Tachycardia Syndrome

A syndrome of ORTHOSTATIC INTOLERANCE combined with excessive upright TACHYCARDIA, and usually without associated ORTHOSTATIC HYPOTENSION. All variants have in common an excessively reduced venous return to the heart (central HYPOVOLEMIA) while upright.

Synonym
Postural Orthostatic Tachycardia Syndrome
Postural Tachycardia Syndrome

Excerpt	Reference
"POTS (postural tachycardia syndrome) is a chronic form of OI (orthostatic intolerance)."	( Medow, MS; Ocon, AJ; Ross, AJ; Stewart, JM, 2014)
"Postural orthostatic tachycardia syndrome is characterized by orthostatic intolerance."	( Brock, M; Chung, TH; Gaddam, SR; Georgiades, C; Kathait, AS; Ober, C, 2016)

Excerpt	Reference
"Patients with POTS (postural tachycardia syndrome) have excessive orthostatic tachycardia (>30 beats/min) when standing from a supine position."	( Biaggioni, I; Black, BK; Brewster, JA; Garland, EM; Ling, JF; Raj, SR; Robertson, D; Shibao, CA, 2012)
"Postural orthostatic tachycardia syndrome has been recognized for decades, but treatment is largely based on anecdotal experience and expert opinion."	( Almasri, J; Fischer, PR; Hasan, B; Klaas, KM; Marwa, B, 2020)

Excerpt	Reference
"Metoprolol is clinically used to treat postural tachycardia syndrome (POTS) in children, but its effectiveness is unsatisfactory."	( Du, J; Du, S; Jin, H; Lin, J; Tang, C; Yang, J; Zhao, J, 2014)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	0 (0.00)	12.5806
2000's	9 (5.73)	18.1394
2010's	107 (68.15)	28.8240
2020's	41 (26.11)	9.53

Drug	Relationship Strength	Studies	Trials
choline	low	1	0
hydrogen sulfide	low	2	0
bupropion	low	1	0
histamine	low	2	0
thioctic acid	low	1	0
melatonin	medium	1	1
thiamine	low	2	0
amitriptyline	low	1	0
atenolol	low	1	0
bisoprolol	medium	1	1
clonidine	low	1	0
amphetamine	low	1	0
brl 42810	low	1	0
guanfacine	low	1	0
losartan	low	1	0
methylphenidate	low	2	0
metoprolol	medium	11	2
midodrine	medium	20	6
modafinil	medium	1	1
nitroglycerin	low	1	0
phentermine	low	1	0
propranolol	medium	12	6
vorinostat	low	1	0
dextroamphetamine	low	1	0
aldosterone	medium	6	1
prednisone	low	1	0
phenylephrine	medium	1	1
pyridostigmine bromide	medium	6	1
pyrroles	low	1	0
thiamine pyrophosphate	low	1	0
2-aminopurine	low	1	0
methoxyhydroxyphenylglycol	low	2	0
fludrocortisone	low	8	0
ribavirin	low	1	0
methyldopa	low	1	0
sq-11725	low	1	0
fomesafen	low	2	0
atomoxetine hydrochloride	medium	4	1
3-iodobenzylguanidine	low	3	0
sertraline	medium	2	1
3,4-dihydroxyphenylglycol	low	2	0
angiotensin ii, des-phe(8)-	low	1	0
omega-n-methylarginine	medium	1	1
ivabradine	medium	18	1
angiotensin ii	medium	4	1
atropine	low	1	0
fludrocortisone acetate	low	1	0
nitroarginine	low	1	0
mycophenolic acid	low	1	0
digoxin	low	1	0
bilirubin	low	1	0
calcitriol	low	1	0
deamino arginine vasopressin	medium	4	1
naltrexone	low	1	0
alpha-synuclein	low	1	0
losartan potassium	low	5	0
pituitrin	low	2	0
mefloquine	low	1	0
atrial natriuretic factor	low	1	0
natriuretic peptide, c-type	low	2	0
phosphatidylcholines	low	1	0
sodium oxybate	low	1	0
cardiovascular agents	medium	10	1
ascorbic acid	medium	1	1
gsk-2816126	low	1	0
technetium tc 99m sulfur colloid	low	1	0
angiotensin i	low	2	0
adrenomedullin	medium	3	1
vitamin b 12	low	1	0
inosine pranobex	low	1	0
carbidopa	low	1	0

Protein Targets (737)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, Beta-lactamase	8	0	0	8
thioredoxin reductase	13	0	0	13
aldehyde dehydrogenase 1 family, member A1	9	0	0	9
IDH1	6	0	0	6
Phosphatidylinositol 4-kinase alpha	0	2	0	2
Xanthine dehydrogenase/oxidase	0	1	0	1
Guanine nucleotide-binding protein G	2	0	0	2
TAR DNA-binding protein 43	4	0	0	4
Phosphatidylinositol 4-kinase type 2-beta	0	2	0	2
Phosphatidylinositol 4-kinase type 2-alpha	0	2	0	2
Phosphatidylinositol 4-kinase beta	0	2	0	2
dopamine D1 receptor	2	0	0	2
GLS protein	6	0	0	6
Thrombopoietin	2	0	0	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	5	0	0	5
cytochrome P450 2D6 isoform 1	5	0	0	5
cytochrome P450 2C19 precursor	4	0	0	4
ras-related protein Rab-9A	5	0	0	5
histone acetyltransferase KAT2A isoform 1	7	0	0	7
lethal factor (plasmid)	6	0	0	6
POU domain, class 2, transcription factor 1	0	0	0	3
Spike glycoprotein	7	0	1	8
ATP-dependent phosphofructokinase	7	0	0	7
AR protein	17	0	0	17
glucocorticoid receptor [Homo sapiens]	11	0	0	11
thyroid hormone receptor beta isoform a	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 2	7	0	0	7
geminin	16	0	0	16
Sex hormone-binding globulin	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	1	2	3
Androgen receptor	0	2	0	2
Mineralocorticoid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	0	0	1
Chain A, HADH2 protein	9	0	0	9
Chain B, HADH2 protein	9	0	0	9
USP1 protein, partial	6	0	0	6
NFKB1 protein, partial	2	0	0	2
cytochrome P450 family 3 subfamily A polypeptide 4	8	0	0	8
cytochrome P450 2D6	7	0	0	7
arylsulfatase A	7	0	0	7
D(1A) dopamine receptor	8	0	0	8
chromobox protein homolog 1	8	0	0	8
atrial natriuretic peptide receptor 2 precursor	2	0	0	2
serine/threonine-protein kinase mTOR isoform 1	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 1	11	0	0	11
muscarinic acetylcholine receptor M1	6	0	0	6
Solute carrier family 22 member 1	0	7	0	11
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
ATP-binding cassette sub-family C member 3	0	13	0	13
Multidrug resistance-associated protein 4	0	13	0	13
Voltage-dependent L-type calcium channel subunit alpha-1F	0	2	0	2
5-hydroxytryptamine receptor 4	0	10	0	10
Bile salt export pump	0	21	0	21
Albumin	0	0	1	1
High affinity nerve growth factor receptor	0	1	2	3
Aldo-keto reductase family 1 member B1	0	4	0	4
Muscarinic acetylcholine receptor M2	0	7	2	12
Muscarinic acetylcholine receptor M4	0	6	1	9
Muscarinic acetylcholine receptor M1	0	3	1	6
Muscarinic acetylcholine receptor M3	0	3	1	6
Muscarinic acetylcholine receptor M4	0	3	1	6
5-hydroxytryptamine receptor 2C	0	2	2	4
Muscarinic acetylcholine receptor M5	0	3	1	6
Muscarinic acetylcholine receptor M5	0	6	1	9
Alpha-2A adrenergic receptor	0	10	4	15
Muscarinic acetylcholine receptor M2	0	3	1	7
Muscarinic acetylcholine receptor M1	0	7	2	12
Angiotensin-converting enzyme	0	4	0	4
D(2) dopamine receptor	0	4	1	5
5-hydroxytryptamine receptor 2A	0	2	2	4
Alpha-2B adrenergic receptor	0	9	3	13
Alpha-2C adrenergic receptor	0	10	4	15
5-hydroxytryptamine receptor 1A	0	11	5	17
Muscarinic acetylcholine receptor M3	0	5	2	9
D(1A) dopamine receptor	0	3	1	4
D(1B) dopamine receptor	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	1	0	2
Sodium-dependent noradrenaline transporter	0	12	2	14
Histamine H2 receptor	0	3	2	5
Alpha-1D adrenergic receptor	0	7	2	10
5-hydroxytryptamine receptor 2A	0	8	1	9
5-hydroxytryptamine receptor 2C	0	10	1	11
5-hydroxytryptamine receptor 1B	0	7	2	9
5-hydroxytryptamine receptor 1D	0	2	2	4
5-hydroxytryptamine receptor 1F	0	2	2	4
5-hydroxytryptamine receptor 2B	0	2	2	4
5-hydroxytryptamine receptor 6	0	1	2	3
Histamine H1 receptor	0	3	1	4
Sodium-dependent serotonin transporter	0	13	2	15
5-hydroxytryptamine receptor 7	0	1	2	3
5-hydroxytryptamine receptor 5A	0	1	2	3
5-hydroxytryptamine receptor 5B	0	1	2	3
Histamine H1 receptor	0	4	2	6
D(3) dopamine receptor	0	3	0	3
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	1	0	1
UDP-glucuronosyltransferase 1A3	0	0	0	1
5-hydroxytryptamine receptor 3A	0	1	2	3
5-hydroxytryptamine receptor 2B	0	8	1	9
Alpha-1A adrenergic receptor	0	6	2	8
Histamine H2 receptor	3	2	1	8
D(1A) dopamine receptor	3	0	0	3
5-hydroxytryptamine receptor 6	0	4	1	5
5-hydroxytryptamine receptor 7	0	4	0	4
Voltage-dependent N-type calcium channel subunit alpha-1B	0	1	0	1
Sodium channel protein type 7 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Sodium-dependent dopamine transporter	0	12	2	14
Potassium voltage-gated channel subfamily H member 2	0	6	0	6
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	3
Sodium channel protein type 5 subunit alpha	0	2	0	2
Sodium channel protein type 9 subunit alpha	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	3	1	4
5-hydroxytryptamine receptor 4	0	1	2	3
Nuclear receptor subfamily 3 group C member 3	0	4	0	4
Canalicular multispecific organic anion transporter 1	0	12	0	12
Sodium channel protein type 2 subunit alpha	0	1	0	1
Ataxin-2	8	0	0	8
Sigma non-opioid intracellular receptor 1	0	6	0	6
5-hydroxytryptamine receptor 3B	0	1	2	3
Sodium channel protein type 3 subunit alpha	0	1	0	1
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Histamine H3 receptor	0	3	2	5
Sodium channel protein type 10 subunit alpha	0	1	0	1
Solute carrier family 22 member 3	0	1	0	1
Phenylethanolamine N-methyltransferase	0	3	0	3
Cytochrome P450 2A6	0	1	0	1
Substance-P receptor	0	1	0	1
Cytochrome P450 2A5	0	1	0	1
Sodium-dependent dopamine transporter	0	6	1	7
Beta-2 adrenergic receptor	0	2	3	6
Sigma non-opioid intracellular receptor 1	0	2	1	3
glucocerebrosidase	1	0	0	1
DNA polymerase kappa isoform 1	5	0	0	5
Atrial natriuretic peptide receptor 3	0	2	0	2
Type-1A angiotensin II receptor	0	5	2	7
Type-1 angiotensin II receptor	0	0	1	1
Type-1B angiotensin II receptor	0	6	0	6
Type-1 angiotensin II receptor	0	5	4	11
Type-2 angiotensin II receptor	0	5	0	5
Type-2 angiotensin II receptor	0	3	0	3
Chain A, Hyaluronidase, phage associated	0	1	0	1
acetylcholinesterase	7	0	0	7
RAR-related orphan receptor gamma	10	0	0	10
GLI family zinc finger 3	9	0	0	9
thioredoxin glutathione reductase	6	0	0	6
retinoic acid nuclear receptor alpha variant 1	9	0	0	9
estrogen-related nuclear receptor alpha	10	0	0	10
estrogen nuclear receptor alpha	14	0	0	14
vitamin D (1,25- dihydroxyvitamin D3) receptor	5	0	0	5
euchromatic histone-lysine N-methyltransferase 2	15	0	0	15
thyroid hormone receptor beta isoform 2	8	0	0	8
lethal(3)malignant brain tumor-like protein 1 isoform I	2	0	0	2
lamin isoform A-delta10	14	0	0	14
Polyphenol oxidase 2	0	1	0	1
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	1	0	1
Urease	0	2	0	2
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	1	0	1
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	6	0	0	6
regulator of G-protein signaling 4	7	0	0	7
Beta-1 adrenergic receptor	0	1	4	6
DNA polymerase iota isoform a (long)	5	0	0	5
Gamma-aminobutyric acid receptor subunit pi	6	1	3	10
Fatty acid-binding protein, liver	0	2	0	2
Beta-2 adrenergic receptor	0	7	6	13
Beta-1 adrenergic receptor	0	6	6	12
Beta-3 adrenergic receptor	0	2	6	8
Gamma-aminobutyric acid receptor subunit beta-1	6	1	3	10
Gamma-aminobutyric acid receptor subunit delta	6	1	3	10
Gamma-aminobutyric acid receptor subunit gamma-2	6	1	3	10
Gamma-aminobutyric acid receptor subunit alpha-5	6	1	3	10
Gamma-aminobutyric acid receptor subunit alpha-3	6	1	3	10
Gamma-aminobutyric acid receptor subunit gamma-1	6	1	3	10
Gamma-aminobutyric acid receptor subunit alpha-2	6	1	3	10
Gamma-aminobutyric acid receptor subunit alpha-4	6	1	3	10
Gamma-aminobutyric acid receptor subunit gamma-3	6	1	3	10
Gamma-aminobutyric acid receptor subunit alpha-6	6	1	3	10
Alpha-1A adrenergic receptor	0	4	4	9
Alpha-1B adrenergic receptor	0	3	3	7
Gamma-aminobutyric acid receptor subunit alpha-1	6	1	3	10
Gamma-aminobutyric acid receptor subunit beta-3	6	1	3	10
Gamma-aminobutyric acid receptor subunit beta-2	6	1	3	10
GABA theta subunit	6	1	3	10
Gamma-aminobutyric acid receptor subunit epsilon	6	1	3	10
glp-1 receptor, partial	4	0	0	4
TDP1 protein	12	0	0	12
estrogen receptor 2 (ER beta)	6	0	0	6
nuclear receptor subfamily 1, group I, member 3	9	0	0	9
progesterone receptor	7	0	0	7
peroxisome proliferator-activated receptor delta	5	0	0	5
thyroid stimulating hormone receptor	2	0	0	2
v-jun sarcoma virus 17 oncogene homolog (avian)	4	0	0	4
Cellular tumor antigen p53	8	0	0	8
Atrial natriuretic peptide receptor 1	0	0	1	1
Atrial natriuretic peptide receptor 1	0	0	1	1
Chain A, 2-oxoglutarate Oxygenase	6	0	0	6
retinoid X nuclear receptor alpha	4	0	0	4
pregnane X nuclear receptor	8	0	0	8
cystic fibrosis transmembrane conductance regulator	0	2	0	2
DNA polymerase beta	3	0	0	3
short transient receptor potential channel 6 isoform 1	0	0	1	1
Muscarinic acetylcholine receptor M1	0	0	0	1
Muscarinic acetylcholine receptor M4	0	1	0	1
Reverse transcriptase/RNaseH	0	0	0	1
Muscarinic acetylcholine receptor	0	1	1	2
Chain A, Putative fructose-1,6-bisphosphate aldolase	2	0	0	2
Chain A, Cruzipain	5	0	0	5
phosphopantetheinyl transferase	5	0	0	5
Microtubule-associated protein tau	3	0	0	3
vitamin D3 receptor isoform VDRA	5	0	0	5
caspase-1 isoform alpha precursor	1	0	0	1
Caspase-7	1	0	0	1
Inositol monophosphatase 1	2	0	0	2
Solute carrier organic anion transporter family member 1B3	0	5	0	6
Solute carrier organic anion transporter family member 1B1	0	5	0	6
ATAD5 protein, partial	5	0	0	5
Beta-1 adrenergic receptor	0	3	0	3
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	4	0	0	4
relaxin receptor 1 isoform 1	1	0	0	1
Interferon beta	7	0	0	7
Acetylcholine receptor subunit alpha	0	1	0	1
Acetylcholine receptor subunit gamma	0	1	0	1
Integrin alpha-5	0	1	0	1
Acetylcholine receptor subunit beta	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	0	1	0	2
UDP-glucuronosyltransferase 1-6	0	1	0	1
Cytochrome P450 2B6	0	0	0	2
UDP-glucuronosyltransferase 1A1	0	1	0	3
Neuronal acetylcholine receptor subunit beta-4	0	1	0	2
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
Cytochrome P450 2C19	0	6	0	6
UDP-glucuronosyltransferase 2B10	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	2
Acetylcholine receptor subunit delta	0	1	0	1
Chain A, Vitamin D Nuclear Receptor	0	0	1	1
Chain A, Ferritin light chain	2	0	0	2
Vitamin D3 receptor	0	0	1	1
PPM1D protein	4	0	0	4
mitogen-activated protein kinase 1	3	0	0	3
nuclear receptor ROR-gamma isoform 1	6	0	0	6
peripheral myelin protein 22	5	0	0	5
Vitamin D-binding protein	0	0	1	1
Cytochrome P450 1A2	0	2	0	3
Cytochrome P450 3A4	0	6	0	8
Androgen receptor	0	1	0	1
Cytochrome P450 2D6	0	7	0	8
Vitamin D3 receptor	0	1	2	4
Cytochrome P450 2C9	0	6	0	7
Vitamin D3 receptor	0	1	1	3
Retinoic acid receptor RXR-alpha	0	0	1	1
Kappa-type opioid receptor	0	2	1	4
Vitamin D3 receptor	0	0	1	1
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	0	1	1
Vitamin D3 receptor	0	1	1	2
Transporter	0	2	0	2
Vitamin D3 receptor A	0	0	2	2
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein	0	0	1	1
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Choline-binding protein	0	0	1	1
Solute carrier family 22 member 1	0	1	0	2
Solute carrier family 22 member 2	0	0	0	2
Solute carrier family 22 member 2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	0	1	0	1
Neuronal acetylcholine receptor subunit beta-3	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-5	0	1	0	1
Acetylcholinesterase	0	4	0	4
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Choline O-acetyltransferase	0	0	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-9	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Solute carrier family 22 member 1	0	4	0	6
High affinity choline transporter 1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-10	0	1	0	1
Solute carrier family 22 member 2	0	3	0	5
Alpha-1B adrenergic receptor	0	0	2	2
cytochrome P450 2C9 precursor	2	0	0	2
Membrane primary amine oxidase	0	1	0	1
5-hydroxytryptamine receptor 3A	0	0	1	1
Solute carrier family 22 member 3	0	3	0	4
5-hydroxytryptamine receptor 1A	0	2	0	2
Alpha-1B adrenergic receptor	0	4	1	5
Alpha-1A adrenergic receptor	0	1	2	3
D	0	2	0	2
D(3) dopamine receptor	0	3	0	3
Alpha-2B adrenergic receptor	0	3	1	4
Amine oxidase [flavin-containing] A	0	3	0	3
Alpha-2C adrenergic receptor	0	3	1	4
Alpha-2A adrenergic receptor	0	3	1	4
Alpha-1D adrenergic receptor	0	4	1	5
D(1B) dopamine receptor	0	2	0	2
Amine oxidase [flavin-containing] B	0	3	0	3
Adenosine receptor A2b	0	0	1	1
Adenosine receptor A2a	0	1	1	3
Alpha-2B adrenergic receptor	0	0	0	2
D(4) dopamine receptor	0	2	0	2
Delta-type opioid receptor	0	3	1	5
D(2) dopamine receptor	0	2	0	2
Mu-type opioid receptor	0	3	1	5
Alpha-2C adrenergic receptor	0	0	0	2
Alpha-2A adrenergic receptor	0	0	0	2
Alpha-2A adrenergic receptor	0	1	0	1
Nischarin	0	2	0	2
Multidrug and toxin extrusion protein 1	0	2	0	2
Nischarin	0	2	0	2
Vasopressin V2 receptor	0	1	1	2
Oxytocin receptor	0	0	1	1
Vasopressin V1a receptor	0	2	2	4
Vasopressin V1b receptor	0	1	1	2
Translocator protein	0	1	0	1
Vasopressin V2 receptor	0	1	1	2
Amine oxidase [flavin-containing] B	0	1	0	1
Sodium-dependent serotonin transporter	0	4	1	5
Amine oxidase [flavin-containing] B	0	1	0	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	2	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	8	0	0	8
Chain A, ATP-DEPENDENT DNA HELICASE Q1	4	0	0	4
interleukin 8	3	0	0	3
PAX8	0	0	0	2
SMAD family member 2	3	0	0	3
SMAD family member 3	3	0	0	3
STAT3, partial	0	1	0	1
Smad3	5	0	0	5
farnesoid X nuclear receptor	4	0	0	4
67.9K protein	3	0	0	3
peroxisome proliferator activated receptor gamma	7	0	0	7
alpha-galactosidase	3	0	0	3
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	8	0	0	8
activating transcription factor 6	3	0	0	3
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	2	0	0	2
NPC intracellular cholesterol transporter 1 precursor	2	0	0	2
cellular tumor antigen p53 isoform a	1	0	0	1
tumor necrosis factor	1	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
signal transducer and activator of transcription 1-alpha/beta isoform alpha	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	2
Voltage-dependent calcium channel gamma-2 subunit	4	0	0	4
Sodium/potassium-transporting ATPase subunit alpha-1	0	2	0	2
Sodium/potassium-transporting ATPase subunit beta-1	0	2	0	2
Integrin beta-3	1	0	0	1
Sodium/potassium-transporting ATPase subunit alpha-2	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-1	0	1	0	1
ATP-dependent translocase ABCB1	0	6	0	10
Integrin alpha-IIb	1	0	0	1
Replicase polyprotein 1ab	0	1	1	2
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-2	0	1	0	1
Glutamate receptor 2	5	1	0	6
ATP-dependent translocase ABCB1	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-2	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-1	0	1	0	1
Nuclear receptor ROR-gamma	5	1	1	7
Sodium/potassium-transporting ATPase subunit beta-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit gamma	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
ATPase family AAA domain-containing protein 5	3	0	0	3
Solute carrier organic anion transporter family member 1A4	0	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
GALC protein	2	0	0	2
aryl hydrocarbon receptor	3	0	0	3
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
Glucocorticoid receptor	0	4	1	5
Glycine receptor subunit alpha-1	0	4	0	4
Glycine receptor subunit beta	0	4	0	4
Glycine receptor subunit alpha-2	0	4	0	4
Glycine receptor subunit alpha-3	0	4	0	4
Luciferase	2	0	0	2
hypoxia-inducible factor 1 alpha subunit	1	0	0	1
Histone H2A.x	4	0	0	4
Chain A, 3-phosphoshikimate 1-carboxyvinyltransferase	0	1	0	1
Chain A, 3-phosphoshikimate 1-carboxyvinyltransferase	0	1	0	1
Glutamine synthetase	0	1	0	1
Cytochrome P450 71B1	0	1	0	2
Glutamine synthetase	0	1	0	1
2-dehydro-3-deoxyphosphooctonate aldolase	0	1	0	1
EWS/FLI fusion protein	5	0	0	5
Polycomb protein EED	0	1	0	1
Polycomb protein SUZ12	0	1	0	1
Histone-lysine N-methyltransferase EZH2	0	2	0	2
cytochrome P450 3A4 isoform 1	6	0	0	6
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Protein (female-specific Histamine Binding Protein 2)	0	0	1	1
aryl hydrocarbon receptor nuclear translocator	0	0	0	1
apical membrane antigen 1, AMA1	2	0	0	2
thyroid stimulating hormone receptor	4	0	0	4
bromodomain adjacent to zinc finger domain 2B	3	0	0	3
potassium voltage-gated channel subfamily H member 2 isoform d	2	0	0	2
transforming acidic coiled-coil-containing protein 3	0	0	0	1
Carbonic anhydrase 12	0	0	0	1
Carbonic anhydrase 1	0	2	0	3
Carbonic anhydrase 2	0	2	0	4
Plasma kallikrein	0	0	0	1
Carbonic anhydrase 3	0	0	0	1
Macrophage migration inhibitory factor	0	2	0	2
Carbonic anhydrase 4	0	1	0	2
Carbonic anhydrase 6	0	2	0	3
Adenosine receptor A1	0	0	0	1
5-hydroxytryptamine receptor 1D	0	0	0	1
Histamine H1 receptor	0	1	2	3
Metabotropic glutamate receptor 5	0	1	1	2
Carbonic anhydrase 5A, mitochondrial	0	1	0	2
Glutamate receptor ionotropic, NMDA 1	0	0	0	1
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase 7	0	1	0	2
Carbonic anhydrase	0	0	0	2
Histamine H3 receptor	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	0	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	2
Glutamate receptor ionotropic, NMDA 2C	0	0	0	1
Histamine N-methyltransferase	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase 9	0	1	0	2
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase-like protein, putative	0	0	0	1
Carbonic anhydrase	0	1	0	3
Carbonic anhydrase	0	0	0	2
Glutamate receptor ionotropic, NMDA 2D	0	0	0	1
Carbonic anhydrase	0	0	0	2
Equilibrative nucleoside transporter 4	0	0	0	1
Carbonic anhydrase 13	0	0	0	1
Glutamate receptor ionotropic, NMDA 3B	0	0	0	1
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	0	1
Carbonic anhydrase 4	0	0	0	1
Carbonic anhydrase 15	0	0	0	1
Carbonic anhydrase 13	0	1	0	2
Histamine H4 receptor	0	1	2	3
Histamine H3 receptor	0	1	0	1
Carboxylic ester hydrolase	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	0	0	1
Carbonic anhydrase 14	0	0	0	1
Carbonic anhydrase 5B, mitochondrial	0	1	0	2
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase, alpha family	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2	0	0	1	1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1	0	0	1	1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4	0	0	1	1
G	1	0	0	1
HLA class I histocompatibility antigen, B alpha chain	1	0	0	1
Neprilysin	0	1	0	1
Angiotensin-converting enzyme	0	1	0	1
Thromboxane A2 receptor	0	1	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Type-1 angiotensin II receptor	0	1	1	2
Squalene synthase	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	2	0	2
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	2	0	2
Inositol hexakisphosphate kinase 1	1	0	0	1
Platelet glycoprotein VI	0	1	1	3
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	1
Type-1 angiotensin II receptor	0	2	1	3
cytochrome P450 2C9, partial	1	0	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
ClpP	1	0	0	1
caspase 7, apoptosis-related cysteine protease	2	0	0	2
caspase-3	2	0	0	2
Bloom syndrome protein isoform 1	4	0	0	4
peripheral myelin protein 22 isoform 1	4	0	0	4
M-phase phosphoprotein 8	3	0	0	3
Cytochrome P450 1A1	0	1	0	1
Cytochrome P450 1A2	0	1	0	1
Myeloperoxidase	0	1	0	1
Cholinesterase	0	2	0	2
Cytochrome P450 2C11	0	1	0	1
Aromatase	0	1	0	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	2	0	2
Metabotropic glutamate receptor 1	0	1	0	1
Acetylcholinesterase	0	1	0	1
Mu-type opioid receptor	0	3	1	4
Nociceptin receptor	0	1	0	1
Melatonin receptor type 1A	0	2	1	3
Melatonin receptor type 1C	0	0	1	1
Melatonin receptor type 1A	0	1	1	2
Melatonin receptor type 1B	0	2	1	3
Melatonin receptor type 1C	0	1	1	2
Melatonin receptor type 1B	0	1	1	2
Nuclear factor erythroid 2-related factor 2	0	0	0	1
Cytochrome P450 1B1	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	0	1
Carboxylic ester hydrolase	0	1	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
endonuclease IV	2	0	0	2
15-lipoxygenase, partial	1	0	0	1
Caspase 6, apoptosis-related cysteine peptidase	0	0	0	1
hypothetical protein, conserved	1	0	0	1
pyruvate kinase	1	0	0	1
lysosomal alpha-glucosidase preproprotein	1	0	0	1
estrogen receptor beta isoform 1	0	1	0	1
importin subunit beta-1 isoform 1	1	0	0	1
flap endonuclease 1	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
snurportin-1	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	1	0	0	1
DNA polymerase eta isoform 1	1	0	0	1
muscleblind-like protein 1 isoform 1	1	0	0	1
Bile salt export pump	0	2	0	2
Rap guanine nucleotide exchange factor 3	3	0	0	3
Epidermal growth factor receptor	0	2	0	2
Tyrosine-protein kinase Fyn	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Cystathionine gamma-lyase	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
phosphoglycerate kinase	1	0	0	1
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
Beta-1 adrenergic receptor	0	4	2	7
Cytochrome P450 2J2	0	3	0	3
D(4) dopamine receptor	0	1	0	1
Transporter	0	3	0	3
Chain A, Inosine-5'-Monophosphate Dehydrogenase 2	0	1	0	1
urokinase-type plasminogen activator precursor	4	0	0	4
plasminogen precursor	4	0	0	4
urokinase plasminogen activator surface receptor precursor	4	0	0	4
survival motor neuron protein isoform d	2	0	0	2
UDP-glucuronosyltransferase 1A9	0	0	0	1
Inosine-5'-monophosphate dehydrogenase 2	0	2	0	2
Glutamate receptor 1	1	1	0	2
Glutamate receptor 3	1	1	0	2
Glutamate receptor 4	1	1	0	2
Inosine-5'-monophosphate dehydrogenase 1	0	2	0	2
Peroxisome proliferator-activated receptor gamma	0	0	1	1
Alpha-synuclein	1	0	0	1
Inosine-5'-monophosphate dehydrogenase	0	1	0	2
UDP-glucuronosyltransferase 1A7	0	0	0	1
UDP-glucuronosyltransferase 1A10	0	0	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	2
5-hydroxytryptamine receptor 3E	0	1	0	1
5-hydroxytryptamine receptor 3B	0	1	0	1
Histidine decarboxylase	0	0	1	1
Delta-type opioid receptor	0	2	1	3
Kappa-type opioid receptor	0	2	1	3
Kappa-type opioid receptor	0	2	1	3
Mu-type opioid receptor	0	3	3	8
Delta-type opioid receptor	0	4	3	9
Kappa-type opioid receptor	0	3	2	8
Nociceptin receptor	0	1	0	1
Mu-type opioid receptor	0	2	1	4
5-hydroxytryptamine receptor 3A	0	1	0	1
5-hydroxytryptamine receptor 3D	0	1	0	1
5-hydroxytryptamine receptor 3C	0	1	0	1
prostaglandin E2 receptor EP2 subtype	0	0	0	1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	2	0	3
Nitric oxide synthase, endothelial	0	3	0	3
Nitric oxide synthase, endothelial	0	4	0	4
Nitric oxide synthase, brain	0	4	0	4
Nitric oxide synthase, brain	0	4	0	4
Nitric oxide synthase, inducible	0	3	0	3
Nitric oxide synthase, inducible	0	4	0	4
Nitric oxide synthase, inducible	0	1	0	1
Nitric oxide synthase, brain	0	2	0	2
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	0	0	1
Neutrophil elastase	0	1	0	1
Proteinase-activated receptor 1	0	1	0	1
Collagenase 3	0	1	0	1
Alpha-1B adrenergic receptor	0	1	0	1
pregnane X receptor	1	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Albumin	0	1	1	2
Adenosine receptor A3	0	2	1	3
Beta-2 adrenergic receptor	0	2	0	3
Cytochrome P450 2C8	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Endothelin-1 receptor	0	1	1	2
Beta-3 adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 1B	0	2	1	3
Adenosine receptor A2a	0	2	1	3
Neuromedin-K receptor	0	0	1	1
Cholecystokinin receptor type A	0	1	1	2
5-hydroxytryptamine receptor 7	0	1	1	2
Beta-2 adrenergic receptor	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
Nuclear receptor subfamily 2 group E member 1	0	0	2	2
NS5	0	0	1	1
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
Transmembrane protease serine 2	0	0	1	1
Polymerase basic protein 2	0	0	1	1
RNA-directed RNA polymerase catalytic subunit	0	0	1	1
Polymerase acidic protein	0	0	1	1
Procathepsin L	0	0	1	1
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Adenosylhomocysteinase	0	0	0	2
Adenosine receptor A1	0	1	0	1
Adenosine receptor A1	0	1	0	1
Genome polyprotein	0	0	1	1
Angiotensin-converting enzyme 2	0	0	1	1
Fumarate hydratase	1	0	0	1
nonstructural protein 1	1	0	0	1
polyprotein	1	0	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	2	0	0	2
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
Transcriptional activator protein LuxR	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
Melanocortin receptor 5	0	2	0	2
Envelope glycoprotein	0	0	1	1
Sigma intracellular receptor 2	0	1	0	1
Free fatty acid receptor 3	0	0	1	1
transcriptional regulator ERG isoform 3	1	0	0	1
Chain A, ykoF	0	0	1	1
Chain B, ykoF	0	0	1	1
Chain A, ThiT	0	0	1	1
Thiamine transporter ThiT	0	0	1	1
Transketolase	0	0	1	1
Thiamine-binding periplasmic protein	0	0	1	1
Acetylcholinesterase	0	1	0	1
1-deoxy-D-xylulose-5-phosphate synthase	0	0	1	1
1-deoxy-D-xylulose-5-phosphate synthase	0	0	1	1
Ubiquitin-like modifier activating enzyme 2	0	1	0	1
SUMO1 activating enzyme subunit 1	0	1	0	1
hexokinase	0	1	0	1
SUMO-conjugating enzyme UBC9	0	1	0	1
eukaryotic translation initiation factor 4 gamma 1 isoform 4	0	1	0	1
eukaryotic translation initiation factor 4E isoform 1	0	1	0	1
Vif	0	1	0	1
Tat	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	0	1	0	1
bifunctional UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Chain A, Histone deacetylase-like amidohydrolase	0	1	0	1
Chain A, Histone deacetylase-like amidohydrolase	0	1	0	1
Histone deacetylase 8	0	1	0	1
Nrf2	1	0	0	1
cystic fibrosis transmembrane conductance regulator ATP-binding cassette sub-family C member 7	0	0	0	1
Histone deacetylase	0	1	0	1
Lysine-specific demethylase 4E	0	1	0	1
Gli1	0	1	0	1
Caspase-7	1	0	0	1
nuclear receptor subfamily 0 group B member 1	0	1	0	1
caspase-3	1	0	0	1
histone deacetylase 9 isoform 3	1	0	0	1
steroidogenic factor 1	0	1	0	1
protein Wnt-3a precursor	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
Histone deacetylase 1	0	2	0	2
Histone deacetylase 3	0	2	1	6
Transient receptor potential cation channel subfamily V member 1	0	1	0	1
Lysine-specific histone demethylase 1A	0	1	0	1
Tyrosine-protein kinase JAK2	0	1	0	1
Bromodomain-containing protein 4	0	1	0	1
Nuclear receptor corepressor 1	0	2	0	2
Tyrosine-protein kinase ABL1	0	1	0	1
Tubulin alpha-1A chain	0	1	0	1
Tubulin beta chain	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
Protein Tat	0	0	1	1
Amyloid-beta precursor protein	0	1	0	1
Heat shock protein HSP 90-alpha	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	0	0	1
Leukotriene A-4 hydrolase	0	1	0	1
Aminopeptidase N	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX12	0	0	0	1
Cannabinoid receptor 1	0	1	0	1
Leukotriene A-4 hydrolase	0	1	0	1
DNA (cytosine-5)-methyltransferase 1	0	1	0	1
Phosphatidylinositol 3-kinase regulatory subunit alpha	0	1	0	1
Proteasome subunit beta type-5	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Vascular endothelial growth factor receptor 2	0	1	0	1
Receptor-type tyrosine-protein kinase FLT3	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	0	1	0	1
Histone deacetylase 4	0	2	1	6
E3 ubiquitin-protein ligase Mdm2	0	1	0	1
Apoptosis regulator BAX	0	0	1	1
Platelet-activating factor acetylhydrolase	0	1	0	1
Histone deacetylase 1	0	2	2	7
Histone deacetylase 1	0	1	0	1
Histone deacetylase	0	1	0	1
Renin	0	1	0	1
Histone deacetylase 3	0	1	0	1
Histone deacetylase-like amidohydrolase	0	2	1	3
Histone deacetylase	0	1	0	1
Histone deacetylase 7	0	2	2	7
Histone deacetylase 2	0	2	2	7
HD2 type histone deacetylase HDA106	0	2	0	2
Polyamine deacetylase HDAC10	0	2	1	6
Histone deacetylase 11	0	2	1	6
Carboxypeptidase B2	0	1	0	1
Histone-lysine N-methyltransferase EHMT2	0	1	0	1
Histone deacetylase 7	0	1	0	1
Histone deacetylase 6	0	1	0	1
Histone deacetylase 4	0	1	0	1
Histone deacetylase 8	0	2	2	7
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
REST corepressor 3	0	1	0	1
Histone deacetylase 6	0	2	2	7
Histone deacetylase 9	0	2	1	6
Histone deacetylase 5	0	2	1	6
Histone deacetylase	0	1	0	1
Nuclear receptor corepressor 2	0	2	0	2
Histone deacetylase 6	0	1	0	1
Histone deacetylase	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Postural Orthostatic Tachycardia Syndrome

Synonyms(2)

Research Excerpts

Overview

Context

Treatment

Research

Studies (157)

Protein Targets (737)

Postural Orthostatic Tachycardia Syndrome

Synonyms(2)

Research Excerpts

Overview

Context

Treatment

Research

Studies (157)

Drugs Studied (91)

Protein Targets (737)