Any metabolite produced by metabolism of a xenobiotic compound.
| Member | Definition | Class |
|---|
| 2-(methylthio)benzothiazole | An organic sulfide that is the methyl thioether of 1,3-benzothiazole-2-thiol. | 2-methylthio-1,3-benzothiazole |
| 2-hydroxyacetanilide | A member of the class of phenols that is 2-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group. A positional isomer of paracetamol which possesses anti-inflammatory, anti-arthritic and anti-platelet aggregation properties. | 2-acetamidophenol; 2'-Hydroxyacetanilide |
| 2-naphthalenemethanol | A naphthylmethanol that is methanol in which one of the methyl hydrogens has been replaced by a (2-naphthyl) group. | (2-naphthyl)methanol |
| 2-naphthoic acid | A naphthoic acid that is naphthalene carrying a carboxy group at position 2. | 2-naphthoic acid |
| 2-toluic acid | A methylbenzoic acid that is benzoic acid substituted by a methyl group at position 2. | o-toluic acid |
| 2,3,4,5-tetrachlorophenate | A tetrachlorophenol in which the chlorines are located at positions 2, 3, 4, and 5. | 2,3,4,5-tetrachlorophenol |
| 2,3,4,6-tetrachlorophenol | A tetrachlorophenol in which the chlorines are located at positions 2, 3, 4, and 6. | 2,3,4,6-tetrachlorophenol |
| 2,4-diamino-6-nitrotoluene | A member of the class of amino-nitrotoluenes that is 2,4-diaminotoluene bearing a nitro substituent at position 6. | 2,4-diamino-6-nitrotoluene |
| 3-amino-5-morpholinomethyl-2-oxazolidinone | A member of the class of oxazolidinones that is 3-amino-1,3-oxazolidin-2-one substituted by a morpholin-4-ylmethyl group at position 5. It is the metabolite of furaltadone, a broad-spectrum antibacterial drug which was widely used as an additive in livestock and aquaculture feed. | 3-amino-5-morpholinomethyl-2-oxazolidinone |
| 3,5-xylenol | A member of the class of phenols that phenol substituted by methyl groups at positions 3 and 5. | 3,5-xylenol |
| 4-chlorophenylacetic acid | A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 4-chlorophenyl group. | 4-chlorophenylacetic acid |
| 4-methylbenzyl alcohol | A methylbenzyl alcohol in which the methyl substituent is para to the hydroxymethyl group. | 4-methylbenzyl alcohol |
| 4-nitrobenzyl alcohol | A member of the class of benzyl alcohols that is benzyl alcohol substituted at the para-position by a nitro group. | 4-nitrobenzyl alcohol |
| 4-sulfanilic acid | An aminobenzenesulfonic acid that is aniline sulfonated at the para-position. | 4-aminobenzenesulfonic acid |
| 6-hydroxychrysene | A hydroxychrysene that is chrysene in which the hydrogen at position 6 has been replaced by a hydroxy group. It is a metabolite of the polycyclic aromatic hydrocarbon chrysene. | chrysen-6-ol |
| 6-methoxy-2-naphthylacetic acid | A monocarboxylic acid consisting of 2-naphthylacetic acid having a methoxy substituent at the 6-position. The active metabolite of the prodrug nabumetone. | (6-methoxy-2-naphthyl)acetic acid |
| act-132577 | A member of the class of sulfamides in which one of the amino groups of sulfonamide is substituted by a 5-(4-bromophenyl)-6-{2-[(5-bromopyrimidin-2-yl)oxy]ethoxy}pyrimidin-4-yl group. An active metabolite of macitentan (obtained by oxidative depropylation), an orphan drug used for the treatment of pulmonary arterial hypertension. | ACT-132577 |
| benzo(a)pyrene-7,8-dione | An o-quinone resulting from the formal oxidation of both of the hydroxy groups of benzo[a]pyrene-cis-7,8-dihydrodiol. Benzo[a]pyrene-7,8-dione is a metabolite of the widespread carcinogen benzo[a]pyrene. | benzo[a]pyrene-7,8-dione |
| cacodylic acid | The organoarsenic compound that is arsenic acid substituted on the central arsenic atom with two methyl groups. | dimethylarsinic acid |
| carboxyl radical | An organic radical anion obtained from carbon dioxide. It is a metabolite of carbon tetrachloride. | oxidooxomethyl |
| cuminol | A member of the class of benzyl alcohols in which the hydrogen at position 4 on the phenyl ring of benzyl alcohol has been replaced by an isopropyl group. | 4-isopropylbenzyl alcohol |
| dichlorodiphenyldichloroethane | A chlorophenylethane that is 2,2-bis(p-chlorophenyl)ethane substituted by two chloro groups at position 1. It is a metabolite of the organochlorine insecticide, DDT. | DDD |
| dihydroresveratrol | A stilbenol that is 1,1'-ethane-1,2-diyldibenzene with hydroxy groups at positions 1, 3 and 4'. | dihydroresveratrol |
| dimethyl disulfide | An organic disulfide that is methane in which one of the hydrogens has been replaced by a methyldisulfanyl group. | dimethyl disulfide |
| diphenylacetic acid | A monocarboxylic acid that is acetic acid where the methyl hydrogens have been replaced by two phenyl groups respectively. | diphenylacetic acid |
| E3040 glucuronide | A member of the class of benzothiazoles that is E3040 in which the hydroxy hydrogen at position 6 has been replaced by a beta-D-glucosiduronic acid group. It is a metabolite of the anti-inflammatory drug, E3040. | E3040 glucuronide |
| ergothioneine | A L-histidine derivative that is N(alpha),N(alpha),N(alpha)-trimethyl-L-histidine in which the hydrogen at position 2 on the imdazole ring is replaced by a mercapto group. A naturally occurring metabolite of histidine synthesized by bacteria and fungi with antioxidant properties. It is found ubiquitously in plants and animals and is present in many human foodstuffs. | ergothioneine thione form; ergothioneine |
| ergothioneine | A L-histidine derivative that is N(alpha),N(alpha),N(alpha)-trimethyl-L-histidine in which the hydrogen at position 2 on the imdazole ring is replaced by a thioxo group. | ergothioneine thione form; ergothioneine |
| ethylene chlorohydrin | A chloroethanol carrying a chloro substituent at position 2. | 2-chloroethanol |
| homoarginine | An L-lysine derivative that is the L-enantiomer of homoarginine. | L-homoarginine |
| hydantoic acid | A member of the class of ureas obtained by formal condensation of the carboxy group of carbamic acid with the amino group of glycine. | N-carbamoylglycine |
| indomethacin | A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis. | indometacin |
| isopentyl alcohol | An primary alcohol that is butan-1-ol in which a hydrogen at position 3 has been replaced by a methyl group. | isoamylol |
| marmesin, (r)-isomer | A marmesin with R-configuration. | nodakenetin |
| melamine | A trimer of cyanamide, with a 1,3,5-triazine skeleton. | melamine |
| methylthioethanol | A primary alcohol that is the S-methyl derivative of mercaptoethanol. It is found as a volatile component in Cucumis melo Var. cantalupensis. | 2-methylthioethanol |
| mono-benzyl phthalate | A phthalic acid monoester resulting from the formal condensation of one of the carboxy groups of phthalic acid with the hydroxy group of benzyl alcohol. It is a major metabolite of the plasticiser butyl benzyl phthalate (BBP). | monobenzyl phthalate |
| monopentyl phthalate | A phthalic acid monoester obtained by formal condensation of one of the carboxy groups of phthalic acid with the hydroxy group of pentanol. | monopentyl phthalate |
| nitrosobenzene | A nitroso compound that is the nitroso derivative of benzene; a diamagnetic hybrid of singlet O2 and azobenzene. | nitrosobenzene |
| octopine | The (1R)-1-carboxyethyl derivative of L-arginine. It is a metabolite released by plant tumours. | D-octopine dizwitterion; D-octopine |
| oxyphenbutazone | A metabolite of phenylbutazone obtained by hydroxylation at position 4 of one of the phenyl rings. Commonly used (as its hydrate) to treat pain, swelling and stiffness associated with arthritis and gout, it was withdrawn from the market 1984 following association with blood dyscrasis and Stevens-Johnson syndrome. | oxyphenbutazone |
| proglumide | A racemate composed of equal amounts of (R)- and (S)-proglumide. A non-selective CCK antagonist that was used primarily for treatment of stomach ulcers, but has been replaced by newer drugs. | N(2)-benzoyl-N,N-dipropyl-alpha-glutamine; proglumide |
| propiolic acid | A terminal acetylenic compound that is a 3-carbon, straight-chain, monounsaturated fatty acid having one acetylenic bond. | propynoic acid |
| raphanusamic acid | A thiazolidinemonocarboxylic acid that is 2-thioxo-1,3-thiazolidine with the carboxy group located at position 4 (the R-enantiomer). | raphanusamic acid |
| triadimenol | A member of the class of triazoles that is 3,3-dimethyl-1-(1,2,4-triazol-1-yl)butane-1,2-diol substituted at position O1 by a 4-chlorophenyl group. A fungicide for cereals, beet and brassicas used to control a range of diseases including powdery mildew, rusts, bunts and smuts. | triadimenol |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 19.9811 | 1 | 3 |
| 67.9K protein | Vaccinia virus | Potency | 5.0119 | 1 | 1 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 34.9656 | 1 | 1 |
| acid sphingomyelinase | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 49.1229 | 2 | 8 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 37.7637 | 1 | 4 |
| Alpha-synuclein | Homo sapiens (human) | Potency | 3.7172 | 1 | 2 |
| AR protein | Homo sapiens (human) | Potency | 35.6630 | 12 | 70 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 32.4783 | 3 | 12 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 18.7671 | 2 | 4 |
| Ataxin-2 | Homo sapiens (human) | Potency | 61.2402 | 1 | 4 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 61.2402 | 1 | 4 |
| BRCA1 | Homo sapiens (human) | Potency | 7.9433 | 1 | 1 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 100.0000 | 1 | 2 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 35.5210 | 1 | 3 |
| caspase-3 | Cricetulus griseus (Chinese hamster) | Potency | 35.8192 | 1 | 4 |
| caspase-3 | Homo sapiens (human) | Potency | 35.5210 | 1 | 3 |
| Caspase-7 | Cricetulus griseus (Chinese hamster) | Potency | 35.8192 | 1 | 4 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 34.3060 | 3 | 18 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 24.4778 | 1 | 4 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 39.8107 | 1 | 2 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 34.3521 | 2 | 3 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 56.2341 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 13.1032 | 1 | 4 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 25.1574 | 1 | 3 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 49.2885 | 1 | 2 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 34.3521 | 2 | 3 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 69.4562 | 1 | 3 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 29.8816 | 1 | 2 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 11.1125 | 1 | 4 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 37.2931 | 1 | 2 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 22.1060 | 2 | 4 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 11.6348 | 1 | 4 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 34.8056 | 1 | 6 |
| DNA dC->dU-editing enzyme APOBEC-3G isoform 1 | Homo sapiens (human) | Potency | 3.1623 | 1 | 1 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 0.1413 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 39.4680 | 1 | 6 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 17.0994 | 1 | 2 |
| endonuclease IV | Escherichia coli | Potency | 14.1254 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 35.5877 | 12 | 73 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 31.9728 | 3 | 15 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 40.7227 | 7 | 63 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 10.3854 | 1 | 4 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 15.4754 | 3 | 3 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 33.3810 | 4 | 12 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 19.7312 | 1 | 2 |
| G | Vesicular stomatitis virus | Potency | 11.1125 | 1 | 4 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 22.1060 | 1 | 2 |
| GALC protein | Homo sapiens (human) | Potency | 1.2589 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 22.1060 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 22.1060 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 22.1060 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 22.1060 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 22.1060 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 22.1060 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 22.1060 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 22.1060 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 22.1060 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 22.1060 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 22.1060 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 22.1060 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 22.1060 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 22.1060 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 22.1060 | 1 | 2 |
| geminin | Homo sapiens (human) | Potency | 9.4381 | 2 | 9 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 31.0774 | 3 | 24 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 10.2663 | 1 | 2 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 9.2069 | 1 | 2 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 29.9870 | 5 | 25 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 35.9744 | 1 | 9 |
| Glycoprotein hormones alpha chain | Homo sapiens (human) | Potency | 1.1220 | 1 | 1 |
| Guanine nucleotide-binding protein G | Homo sapiens (human) | Potency | 10.5843 | 2 | 3 |
| heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | Homo sapiens (human) | Potency | 14.1254 | 1 | 1 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 41.3715 | 2 | 14 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 29.8816 | 1 | 6 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| histone deacetylase 9 isoform 3 | Homo sapiens (human) | Potency | 26.7971 | 2 | 3 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 105.4170 | 2 | 7 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 11.1126 | 1 | 4 |
| hypothetical protein, conserved | Trypanosoma brucei | Potency | 14.1254 | 1 | 1 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 34.7736 | 2 | 8 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 17.8102 | 3 | 7 |
| IDH1 | Homo sapiens (human) | Potency | 14.4191 | 1 | 2 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 11.1126 | 1 | 8 |
| Interferon beta | Homo sapiens (human) | Potency | 11.1126 | 1 | 4 |
| interleukin 8 | Homo sapiens (human) | Potency | 72.2601 | 1 | 3 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 23.7296 | 1 | 3 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 47.9757 | 2 | 6 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 0.7943 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 17.2168 | 2 | 3 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 32.4648 | 1 | 2 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 1.5849 | 1 | 1 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 1.7392 | 1 | 2 |
| NPC intracellular cholesterol transporter 1 precursor | Homo sapiens (human) | Potency | 2.5119 | 1 | 1 |
| Nrf2 | Homo sapiens (human) | Potency | 8.5003 | 2 | 2 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 43.3370 | 4 | 22 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 24.5192 | 1 | 2 |
| nuclear factor NF-kappa-B p105 subunit isoform 1 | Homo sapiens (human) | Potency | 44.6684 | 1 | 2 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 45.5896 | 2 | 7 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 26.0547 | 1 | 4 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 19.9129 | 2 | 7 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 32.1561 | 3 | 20 |
| P53 | Homo sapiens (human) | Potency | 7.0795 | 1 | 1 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 48.6078 | 1 | 2 |
| Parkin | Homo sapiens (human) | Potency | 17.3608 | 2 | 2 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 84.9214 | 1 | 1 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 19.9765 | 5 | 24 |
| Peroxisome proliferator-activated receptor alpha | Homo sapiens (human) | Potency | 47.3936 | 1 | 2 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 29.0388 | 5 | 21 |
| PINK1 | Homo sapiens (human) | Potency | 14.1254 | 1 | 1 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 0.8913 | 1 | 1 |
| polyprotein | Zika virus | Potency | 19.7312 | 1 | 2 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 35.6770 | 2 | 16 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 48.7212 | 1 | 3 |
| progesterone receptor | Homo sapiens (human) | Potency | 27.9295 | 2 | 13 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 41.3409 | 2 | 25 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 6.3096 | 1 | 2 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 49.2053 | 3 | 25 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 18.6767 | 4 | 33 |
| serine/threonine-protein kinase mTOR isoform 1 | Homo sapiens (human) | Potency | 4.6451 | 1 | 1 |
| serine/threonine-protein kinase PLK1 | Homo sapiens (human) | Potency | 23.7781 | 1 | 1 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 16.2982 | 2 | 9 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 16.2982 | 2 | 9 |
| Smad3 | Homo sapiens (human) | Potency | 6.3514 | 1 | 2 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 19.7312 | 1 | 2 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 1.7560 | 1 | 2 |
| TDP1 protein | Homo sapiens (human) | Potency | 22.8743 | 2 | 10 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 10.0000 | 1 | 1 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 66.4066 | 2 | 4 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 32.7659 | 3 | 18 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 31.5008 | 2 | 5 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 34.5520 | 5 | 17 |
| tumor necrosis factor | Homo sapiens (human) | Potency | 74.9780 | 1 | 1 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 0.8913 | 1 | 1 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 0.8913 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 31.8794 | 2 | 3 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 30.5087 | 2 | 11 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 17.2176 | 5 | 17 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 22.2852 | 5 | 7 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 35.9744 | 1 | 9 |
| Vpr | Human immunodeficiency virus 1 | Potency | 35.4813 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 1-deoxy-D-xylulose-5-phosphate synthase | Escherichia coli K-12 | IC50 | 208.0000 | 1 | 1 |
| 3',5'-cyclic-AMP phosphodiesterase | Sus scrofa (pig) | IC50 | 1,000.0000 | 1 | 1 |
| 5'-nucleotidase | Homo sapiens (human) | IC50 | 8.2000 | 1 | 1 |
| 5'-nucleotidase | Rattus norvegicus (Norway rat) | IC50 | 70.1000 | 1 | 1 |
| Adenosine receptor A1 | Rattus norvegicus (Norway rat) | IC50 | 164.0000 | 1 | 1 |
| Adenosine receptor A2a | Rattus norvegicus (Norway rat) | IC50 | 164.0000 | 1 | 1 |
| Albumin | Homo sapiens (human) | Ki | 15,135,600,000.0000 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Bos taurus (cattle) | IC50 | 5.0000 | 1 | 2 |
| Aldo-keto reductase family 1 member B1 | Homo sapiens (human) | IC50 | 6.0000 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Homo sapiens (human) | Ki | 102.1000 | 1 | 2 |
| Aldo-keto reductase family 1 member C1 | Homo sapiens (human) | IC50 | 108.6667 | 3 | 3 |
| Aldo-keto reductase family 1 member C2 | Homo sapiens (human) | IC50 | 48.2567 | 6 | 6 |
| Aldo-keto reductase family 1 member C3 | Homo sapiens (human) | IC50 | 3.0988 | 8 | 8 |
| Aldo-keto reductase family 1 member C3 | Homo sapiens (human) | Ki | 1.1850 | 2 | 2 |
| Aldo-keto reductase family 1 member C4 | Homo sapiens (human) | IC50 | 77.0000 | 2 | 2 |
| Alkaline phosphatase, tissue-nonspecific isozyme | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| Androgen receptor | Rattus norvegicus (Norway rat) | IC50 | 15.4882 | 1 | 1 |
| Aromatase | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 66.0000 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Rattus norvegicus (Norway rat) | Ki | 2.6000 | 1 | 1 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | IC50 | 30.0000 | 1 | 2 |
| Beta lactamase (plasmid) | Pseudomonas aeruginosa | IC50 | 43.5450 | 1 | 1 |
| Bifunctional epoxide hydrolase 2 | Homo sapiens (human) | IC50 | 1.0000 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 44.4400 | 3 | 3 |
| C-X-C chemokine receptor type 3 | Homo sapiens (human) | IC50 | 0.0500 | 1 | 1 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 235.0000 | 1 | 1 |
| Canalicular multispecific organic anion transporter 1 | Rattus norvegicus (Norway rat) | Ki | 3.8400 | 1 | 1 |
| caspase recruitment domain family, member 15 | Homo sapiens (human) | IC50 | 6.6330 | 1 | 1 |
| Chain A, Leukotriene A-4 hydrolase | Homo sapiens (human) | IC50 | 247.0000 | 1 | 17 |
| Chain A, membrane-associated prostaglandin E synthase-2 | Macaca fascicularis (crab-eating macaque) | IC50 | 1,000.0000 | 1 | 1 |
| Cholecystokinin receptor type A | Cavia porcellus (domestic guinea pig) | IC50 | 800.0000 | 1 | 1 |
| Cholecystokinin receptor type A | Rattus norvegicus (Norway rat) | IC50 | 250.0000 | 1 | 1 |
| Choline O-acetyltransferase | Rattus norvegicus (Norway rat) | Ki | 40,000.0000 | 1 | 1 |
| Cytochrome c oxidase subunit 2 | Homo sapiens (human) | IC50 | 0.3400 | 2 | 2 |
| Cytosolic phospholipase A2 gamma | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Dehydrogenase/reductase SDR family member 9 | Homo sapiens (human) | IC50 | 14.0000 | 1 | 1 |
| Endothelin receptor type B | Homo sapiens (human) | IC50 | 0.9870 | 2 | 2 |
| Endothelin receptor type B | Rattus norvegicus (Norway rat) | IC50 | 0.9870 | 1 | 1 |
| Endothelin-1 receptor | Homo sapiens (human) | IC50 | 0.0034 | 2 | 2 |
| Epidermal growth factor receptor | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| exodeoxyribonuclease V subunit RecB | Escherichia coli str. K-12 substr. MG1655 | IC50 | 63.5370 | 1 | 1 |
| exodeoxyribonuclease V subunit RecC | Escherichia coli str. K-12 substr. MG1655 | IC50 | 63.5370 | 1 | 1 |
| exodeoxyribonuclease V subunit RecD | Escherichia coli str. K-12 substr. MG1655 | IC50 | 63.5370 | 1 | 1 |
| Fatty acid synthase | Gallus gallus (chicken) | IC50 | 2,213.0000 | 1 | 1 |
| glucose-6-phosphate 1-dehydrogenase isoform b | Homo sapiens (human) | IC50 | 80.0000 | 1 | 1 |
| glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase | Plasmodium berghei | IC50 | 63.1250 | 3 | 4 |
| Histamine H2 receptor | Rattus norvegicus (Norway rat) | IC50 | 2,500.0000 | 1 | 1 |
| Indoleamine 2,3-dioxygenase 1 | Mus musculus (house mouse) | IC50 | 0.0820 | 1 | 2 |
| Interleukin-8 | Homo sapiens (human) | IC50 | 0.0500 | 1 | 1 |
| Intestinal-type alkaline phosphatase | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| Lactoylglutathione lyase | Homo sapiens (human) | Ki | 22.1667 | 3 | 3 |
| large T antigen | Betapolyomavirus macacae | IC50 | 6.2000 | 1 | 1 |
| Leukotriene A-4 hydrolase | Homo sapiens (human) | IC50 | 196.0000 | 2 | 2 |
| Mcl-1 | Homo sapiens (human) | IC50 | 54.0000 | 1 | 1 |
| Multidrug and toxin extrusion protein 1 | Homo sapiens (human) | IC50 | 500.0000 | 1 | 1 |
| Multidrug resistance associated protein | Homo sapiens (human) | Ki | 5.6000 | 1 | 1 |
| Multidrug resistance-associated protein 1 | Homo sapiens (human) | IC50 | 12.3000 | 2 | 2 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 5.8000 | 1 | 1 |
| Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 4 |
| Muscarinic acetylcholine receptor M2 | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 3 |
| Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 3 |
| Muscarinic acetylcholine receptor M4 | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 3 |
| Muscarinic acetylcholine receptor M5 | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 3 |
| Neuronal acetylcholine receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | IC50 | 0.0040 | 1 | 1 |
| Neuronal acetylcholine receptor subunit beta-2 | Rattus norvegicus (Norway rat) | IC50 | 0.0040 | 1 | 1 |
| Nicotinate phosphoribosyltransferase | Homo sapiens (human) | Ki | 0.0002 | 1 | 2 |
| Nitric oxide synthase, inducible | Mus musculus (house mouse) | IC50 | 24.3500 | 5 | 5 |
| P2Y purinoceptor 12 | Rattus norvegicus (Norway rat) | IC50 | 0.9600 | 1 | 1 |
| Phospholipase A-2-activating protein | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| Phospholipase A2, major isoenzyme | Sus scrofa (pig) | IC50 | 1,000.0000 | 1 | 1 |
| Polyunsaturated fatty acid 5-lipoxygenase | Rattus norvegicus (Norway rat) | IC50 | 771.4000 | 5 | 5 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | IC50 | 301.9950 | 1 | 1 |
| Procathepsin L | Homo sapiens (human) | IC50 | 11.8000 | 1 | 1 |
| Prostaglandin D2 receptor | Mus musculus (house mouse) | IC50 | 10.0000 | 1 | 1 |
| Prostaglandin D2 receptor | Mus musculus (house mouse) | Ki | 10.0000 | 2 | 2 |
| Prostaglandin D2 receptor 2 | Homo sapiens (human) | Ki | 4.0250 | 2 | 2 |
| Prostaglandin E synthase | Homo sapiens (human) | IC50 | 40.6000 | 1 | 1 |
| Prostaglandin E2 receptor EP1 subtype | Mus musculus (house mouse) | Ki | 10.0000 | 2 | 2 |
| Prostaglandin E2 receptor EP2 subtype | Mus musculus (house mouse) | Ki | 10.0000 | 2 | 2 |
| Prostaglandin E2 receptor EP3 subtype | Mus musculus (house mouse) | Ki | 10.0000 | 2 | 2 |
| Prostaglandin E2 receptor EP4 subtype | Mus musculus (house mouse) | Ki | 10.0000 | 2 | 2 |
| Prostaglandin G/H synthase 1 | Homo sapiens (human) | IC50 | 1.1076 | 57 | 63 |
| Prostaglandin G/H synthase 1 | Mus musculus (house mouse) | IC50 | 0.0110 | 2 | 2 |
| Prostaglandin G/H synthase 1 | Ovis aries (sheep) | IC50 | 0.9926 | 74 | 91 |
| Prostaglandin G/H synthase 1 | Ovis aries (sheep) | Ki | 7.9000 | 1 | 1 |
| Prostaglandin G/H synthase 1 | Bos taurus (cattle) | IC50 | 12.6423 | 11 | 14 |
| Prostaglandin G/H synthase 1 | Rattus norvegicus (Norway rat) | IC50 | 0.5461 | 7 | 7 |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | IC50 | 8.1537 | 95 | 108 |
| Prostaglandin G/H synthase 2 | Mus musculus (house mouse) | IC50 | 1.2712 | 14 | 23 |
| Prostaglandin G/H synthase 2 | Ovis aries (sheep) | IC50 | 73.7305 | 26 | 28 |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | Ki | 1.5000 | 1 | 1 |
| Prostaglandin G/H synthase 2 | Ovis aries (sheep) | Ki | 9.8600 | 1 | 1 |
| Prostaglandin G/H synthase 2 | Bos taurus (cattle) | IC50 | 0.7764 | 6 | 9 |
| Prostaglandin G/H synthase 2 | Rattus norvegicus (Norway rat) | IC50 | 0.5504 | 7 | 7 |
| Prostaglandin-H2 D-isomerase | Mus musculus (house mouse) | IC50 | 1.1000 | 2 | 2 |
| receptor-interacting serine/threonine-protein kinase 2 isoform 1 | Homo sapiens (human) | IC50 | 6.6330 | 1 | 1 |
| Retinal dehydrogenase 1 | Rattus norvegicus (Norway rat) | IC50 | 2.5000 | 1 | 1 |
| Rho-associated protein kinase 2 | Rattus norvegicus (Norway rat) | IC50 | 7.7000 | 1 | 2 |
| Serum paraoxonase/arylesterase 1 | Homo sapiens (human) | Ki | 97.0000 | 1 | 1 |
| Sigma intracellular receptor 2 | Rattus norvegicus (Norway rat) | IC50 | 0.4900 | 1 | 1 |
| Sodium- and chloride-dependent betaine transporter | Rattus norvegicus (Norway rat) | IC50 | 0.2000 | 1 | 1 |
| Sodium- and chloride-dependent GABA transporter 1 | Rattus norvegicus (Norway rat) | IC50 | 0.2000 | 1 | 1 |
| Sodium- and chloride-dependent GABA transporter 2 | Rattus norvegicus (Norway rat) | IC50 | 0.2000 | 1 | 1 |
| Sodium- and chloride-dependent GABA transporter 3 | Rattus norvegicus (Norway rat) | IC50 | 0.2000 | 1 | 1 |
| Sodium-dependent dopamine transporter | Rattus norvegicus (Norway rat) | IC50 | 14.0000 | 1 | 1 |
| Solute carrier family 22 member 4 | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| Solute carrier family 22 member 6 | Homo sapiens (human) | IC50 | 3.0000 | 1 | 1 |
| Solute carrier family 22 member 6 | Rattus norvegicus (Norway rat) | Ki | 15.4000 | 2 | 3 |
| Solute carrier family 22 member 8 | Homo sapiens (human) | Ki | 5.9500 | 1 | 1 |
| Solute carrier organic anion transporter family member 1A3 | Rattus norvegicus (Norway rat) | Ki | 1,000.0000 | 1 | 1 |
| Solute carrier organic anion transporter family member 1B1 | Homo sapiens (human) | IC50 | 12.0000 | 1 | 1 |
| Solute carrier organic anion transporter family member 1B1 | Homo sapiens (human) | Ki | 11.0000 | 1 | 1 |
| Solute carrier organic anion transporter family member 1B3 | Homo sapiens (human) | IC50 | 41.0000 | 1 | 1 |
| Solute carrier organic anion transporter family member 1B3 | Homo sapiens (human) | Ki | 38.0000 | 1 | 1 |
| Solute carrier organic anion transporter family member 2B1 | Homo sapiens (human) | IC50 | 140.0000 | 1 | 1 |
| Solute carrier organic anion transporter family member 2B1 | Homo sapiens (human) | Ki | 130.0000 | 1 | 1 |
| Substance-P receptor | Cavia porcellus (domestic guinea pig) | IC50 | 5.7000 | 1 | 1 |
| Thromboxane-A synthase | Homo sapiens (human) | IC50 | 50.0500 | 2 | 2 |
| Transient receptor potential cation channel subfamily A member 1 | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
| Uracil nucleotide/cysteinyl leukotriene receptor | Homo sapiens (human) | IC50 | 28.8000 | 2 | 2 |