Page last updated: 2024-12-08

bw 443c

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID139474
MeSH IDM0155768

Synonyms (8)

Synonym
88331-14-0
bw-443c
l-prolinamide, l-tyrosyl-d-arginylglycyl-4-nitro-l-phenylalanyl-, diacetate (salt)
tyr-arg-gly-(4-nitro-phe)-pro-nh2
bw 443c
bw443c
DTXSID00236968
acetic acid;(2s)-n-[2-[[(2r)-2-[[(2s)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]acetyl]-1-[(2s)-2-amino-3-(4-nitrophenyl)propanoyl]pyrrolidine-2-carboxamide

Research Excerpts

Pharmacokinetics

ExcerptReferenceRelevance
" Blood was sampled at intervals on all occasions, plasma concentrations were determined by radioimmunoassay and pharmacokinetic profiles were analysed using NONLIN."( A preliminary study of the pharmacodynamics and pharmacokinetics of a novel enkephalin analogue [Tyr-D.Arg-Gly-Phe (4NO2).Pro.NH2 (BW443C)] in healthy volunteers.
Dean, K; Jeal, S; Moody, SG; Peck, AW; Posner, J; Rutter, G; Telekes, A, 1988
)
0.27

Dosage Studied

ExcerptRelevanceReference
" In heat-induced models, that detect centrally acting opioids, BW443C is effective only at high doses and at time intervals after dosing sufficient to allow slow penetration of drug into the CNS."( Antinociceptive effects of the novel opioid peptide BW443C compared with classical opiates; peripheral versus central actions.
Follenfant, RL; Hardy, GW; Lowe, LA; Schneider, C; Smith, TW, 1988
)
0.27
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (11)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (27.27)18.7374
1990's8 (72.73)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.23

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.23 (24.57)
Research Supply Index2.48 (2.92)
Research Growth Index4.71 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.23)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (9.09%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other10 (90.91%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]