ascorbic-acid and Endomyocardial-Fibrosis

ascorbic-acid has been researched along with Endomyocardial-Fibrosis* in 1 studies

Other Studies

1 other study(ies) available for ascorbic-acid and Endomyocardial-Fibrosis

ArticleYear
Effect of anti-oxidant treatment on hyperhomocysteinemia-induced myocardial fibrosis and diastolic dysfunction.
    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2008, Volume: 27, Issue:11

    Recent studies demonstrate that hyperhomocysteinemia is a risk factor for heart failure. Oxidant stress is a major mediator of the pathogenic effects of hyperhomocysteinemia.. We utilized a rat model of diet-induced hyperhomocysteinemia to examine whether treatment with an anti-oxidant vitamin (C&E) combination will prevent hyperhomocysteinemia-induced myocardial fibrosis.. Dietary anti-oxidant therapy attenuated hyperhomocysteinemia-induced increases in myocardial oxidant stress and myocardial fibrosis, and diastolic dysfunction.. Hyperhomocysteinemia acts via oxidant stress to promote myocardial fibrosis and dysfunction. Dietary anti-oxidant therapy could be an important preventive and therapeutic strategy in diastolic heart failure.

    Topics: Animals; Antioxidants; Ascorbic Acid; Body Weight; Collagen; Coronary Vessels; Diastole; Endomyocardial Fibrosis; Heart; Homocysteine; Hyperhomocysteinemia; Male; Organ Size; Rats; Rats, Sprague-Dawley; Vitamin E

2008
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