An EC 1.14.11.* (oxidoreductase acting on paired donors, 2-oxoglutarate as one donor, incorporating 1 atom each of oxygen into both donors) inhibitor that interferes with the action of procollagen-proline dioxygenase (EC 1.14.11.2).
ChEBI ID: 132365
| Member | Definition | Class |
|---|---|---|
| ethyl protocatechuate | An ethyl ester resulting from the formal condensation of the carboxy group of 3,4-dihydroxybenzoic acid with ethanol. It is the anti-oxidative component of peanut seed testa. | ethyl 3,4-dihydroxybenzoate |
| fg-4592 | An N-acylglycine resulting from the formal condensation of the amino group of glycine with the carboxy group of 4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxylic acid. It is an inhibitor of hypoxia inducible factor prolyl hydroxylase (HIF-PH). | roxadustat |
| protocatechuic acid | A dihydroxybenzoic acid in which the hydroxy groups are located at positions 3 and 4. | 3,4-dihydroxybenzoic acid |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 53 (4.54) | 18.7374 |
| 1990's | 82 (7.03) | 18.2507 |
| 2000's | 254 (21.77) | 29.6817 |
| 2010's | 495 (42.42) | 24.3611 |
| 2020's | 283 (24.25) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 39 (3.22%) | 5.53% |
| Reviews | 42 (3.47%) | 6.00% |
| Case Studies | 11 (0.91%) | 4.05% |
| Observational | 1 (0.08%) | 0.25% |
| Other | 1,118 (92.32%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| AR protein | Homo sapiens (human) | Potency | 23.2764 | 2 | 2 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 19.4971 | 1 | 1 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 11.8832 | 1 | 1 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 12.0382 | 3 | 3 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 5.8992 | 1 | 1 |
| G | Vesicular stomatitis virus | Potency | 19.4971 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 0.7308 | 1 | 1 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 25.1387 | 2 | 3 |
| GLS protein | Homo sapiens (human) | Potency | 3.9811 | 1 | 1 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 77.7779 | 2 | 3 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 19.4971 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 19.4971 | 1 | 2 |
| Interferon beta | Homo sapiens (human) | Potency | 19.4971 | 1 | 1 |
| lethal(3)malignant brain tumor-like protein 1 isoform I | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| lysosomal alpha-glucosidase preproprotein | Homo sapiens (human) | Potency | 5.0119 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 2.8184 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 13.3332 | 1 | 1 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 31.6228 | 1 | 1 |
| Rap guanine nucleotide exchange factor 3 | Homo sapiens (human) | Potency | 125.8920 | 1 | 2 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 26.6032 | 1 | 1 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 24.5202 | 1 | 1 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 11.5410 | 2 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 3-dehydroquinate synthase | Escherichia coli K-12 | Ki | 54.5000 | 2 | 2 |
| 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 | Homo sapiens (human) | IC50 | 137.0000 | 1 | 1 |
| 72 kDa type IV collagenase | Homo sapiens (human) | IC50 | 137.0000 | 1 | 1 |
| Alpha-(1,3)-fucosyltransferase 7 | Homo sapiens (human) | IC50 | 137.0000 | 1 | 1 |
| Alpha-glucosidase MAL12 | Saccharomyces cerevisiae S288C | IC50 | 192.5500 | 2 | 2 |
| Alpha-ketoglutarate-dependent dioxygenase FTO | Homo sapiens (human) | IC50 | 9.8000 | 1 | 1 |
| Anthrax toxin receptor 2 | Homo sapiens (human) | IC50 | 300.0000 | 1 | 1 |
| Carbonic anhydrase | Dicentrarchus labrax (European seabass) | Ki | 3.2100 | 1 | 1 |
| Carbonic anhydrase 1 | Homo sapiens (human) | Ki | 0.8650 | 2 | 2 |
| Carbonic anhydrase 12 | Homo sapiens (human) | Ki | 2.4600 | 2 | 2 |
| Carbonic anhydrase 14 | Homo sapiens (human) | Ki | 0.7750 | 1 | 2 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 0.5400 | 2 | 2 |
| Carbonic anhydrase 4 | Homo sapiens (human) | Ki | 2.4500 | 1 | 1 |
| Carbonic anhydrase 6 | Homo sapiens (human) | Ki | 4.7200 | 2 | 2 |
| Carbonic anhydrase 7 | Homo sapiens (human) | Ki | 4.3100 | 1 | 2 |
| Carbonic anhydrase 9 | Homo sapiens (human) | Ki | 2.6150 | 2 | 2 |
| cathepsin L1 | Homo sapiens (human) | IC50 | 59.6420 | 1 | 1 |
| CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 | Homo sapiens (human) | IC50 | 137.0000 | 1 | 1 |
| Dihydroorotate dehydrogenase | Leishmania major | IC50 | 961.0000 | 1 | 2 |
| Egl nine homolog 1 | Homo sapiens (human) | IC50 | 0.8836 | 10 | 10 |
| Hypoxia-inducible factor 1-alpha inhibitor | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| M18 aspartyl aminopeptidase | Plasmodium falciparum 3D7 | IC50 | 0.4794 | 1 | 1 |
| Matrilysin | Homo sapiens (human) | IC50 | 137.0000 | 1 | 1 |
| Polyphenol oxidase 2 | Agaricus bisporus | IC50 | 100.0000 | 1 | 1 |
| Prolyl 3-hydroxylase OGFOD1 | Homo sapiens (human) | IC50 | 1.0000 | 1 | 1 |
| Prolyl 4-hydroxylase | Paramecium bursaria Chlorella virus 1 | IC50 | 5.0000 | 1 | 1 |
| Prolyl 4-hydroxylase | Paramecium bursaria Chlorella virus 1 | Ki | 1.0700 | 1 | 1 |
| Prolyl 4-hydroxylase subunit alpha-1 | Gallus gallus (chicken) | Ki | 5.0000 | 1 | 1 |
| Xanthine dehydrogenase/oxidase | Bos taurus (cattle) | IC50 | 5.8000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Chain A, Protocatechuate 3,4-dioxygenase alpha chain | Pseudomonas putida | Kd | 1,100.0000 | 1 | 1 |
| Chain B, Protocatechuate 3,4-dioxygenase beta chain | Pseudomonas putida | Kd | 1,100.0000 | 1 | 1 |
| Egl nine homolog 1 | Homo sapiens (human) | EC50 | 6.1100 | 1 | 1 |
| Thyroid hormone receptor alpha | Homo sapiens (human) | EC50 | 0.0327 | 1 | 1 |
| Thyroid hormone receptor beta | Homo sapiens (human) | EC50 | 0.0129 | 1 | 1 |