An EC 1.17.3.* (oxidoreductase acting on CH or CH2 with oxygen as acceptor) inhibitor that interferes with the action of xanthine oxidase (EC 1.17.3.2).
| Member | Definition | Class |
|---|
| 2-amino-4-hydroxy-6-formylpteridine | Pterin carrying a formyl group at position 6. | 6-formylpterin |
| 8-azaadenine | A triazolopyrimidine that is [1,2,3]triazolo[4,5-d]pyrimidine bearing an amino substituent at position 7. | 8-azaadenine |
| allopurinol | A bicyclic structure comprising a pyrazole ring fused to a hydroxy-substituted pyrimidine ring. | allopurinol |
| aspalathin | A member of the class of dihydrochalcones that is the 2-C-beta-D-glucopyranide of phloroglucinol and which is substituted at position 4 by a 3-(3,4-dihydroxyphenyl)propanoyl group. A metabolite of red bush, Aspalathus linearis (and present in the herbal tea made from the leaves), aspalathin exhibits significant hypoglycemic activity. | aspalathin |
| febuxostat | A 1,3-thiazolemonocarboxylic acid that is 4-methyl-1,3-thiazole-5-carboxylic acid which is substituted by a 3-cyano-4-(2-methylpropoxy)phenyl group at position 2. It is an orally-active, potent, and selective xanthine oxidase inhibitor used for the treatment of chronic hyperuricaemia in patients with gout. | febuxostat |
| oxypurinol | A pyrazolopyrimidine that is 4,5,6,7-tetrahydro-H-pyrazolo[3,4-d]pyrimidine substituted by oxo groups at positions 4 and 6. | alloxanthine |
| pedalitin | A tetrahydroxy-monohydroxy-flavone, with the four hydroxy groups at C-3',-4',-5 and 6, and the methoxy group at C-7. It has been isolated from a number of plant species, including Eremosparton songoricum, Rabdosia japonica and Ruellia tuberosa. | pedalitin |
| procyanidin C1 | A proanthocyanidin consisting of three (-)-epicatechin units joined by two successive (4beta->8)-linkages. | procyanidin C1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| acetylcholinesterase | Homo sapiens (human) | Potency | 29.2206 | 2 | 2 |
| AR protein | Homo sapiens (human) | Potency | 4.3072 | 9 | 10 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 0.0282 | 2 | 2 |
| Ataxin-2 | Homo sapiens (human) | Potency | 0.1496 | 1 | 1 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 0.1587 | 2 | 2 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 0.3981 | 2 | 2 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 5.0119 | 1 | 1 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 27.5404 | 1 | 1 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 0.0422 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 13.8448 | 7 | 10 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 14.6136 | 2 | 3 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 34.9212 | 6 | 19 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 0.0251 | 1 | 1 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 29.5659 | 1 | 1 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 15.8716 | 2 | 2 |
| G | Vesicular stomatitis virus | Potency | 27.5404 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 0.8384 | 2 | 2 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 7.5272 | 2 | 2 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 7.7894 | 1 | 2 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 35.2315 | 1 | 2 |
| histone deacetylase 9 isoform 3 | Homo sapiens (human) | Potency | 0.4540 | 2 | 2 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 27.5404 | 1 | 1 |
| IDH1 | Homo sapiens (human) | Potency | 25.9290 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 27.5404 | 1 | 2 |
| Interferon beta | Homo sapiens (human) | Potency | 27.5404 | 1 | 1 |
| interleukin 8 | Homo sapiens (human) | Potency | 74.9780 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 6.3096 | 1 | 1 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 0.1726 | 2 | 2 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 50.7896 | 2 | 2 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 0.0680 | 3 | 3 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 18.8322 | 1 | 1 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 10.5901 | 1 | 1 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 34.3478 | 1 | 2 |
| progesterone receptor | Homo sapiens (human) | Potency | 28.8976 | 2 | 2 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 0.0108 | 2 | 2 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 1.0000 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 0.0808 | 3 | 3 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 9.1223 | 2 | 2 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 15.4172 | 2 | 2 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 15.4172 | 2 | 2 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 1.0000 | 1 | 1 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 5.8048 | 1 | 1 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 0.1000 | 1 | 1 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 15.7585 | 2 | 4 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 7.7857 | 3 | 3 |
| transcriptional regulator ERG isoform 3 | Homo sapiens (human) | Potency | 0.7943 | 1 | 1 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 7.3961 | 2 | 2 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 35.2315 | 1 | 2 |