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monoterpenoid indole alkaloid

A terpenoid indole alkaloid which is biosynthesised from L-tryptophan and diisoprenoid (usually secolaganin) building blocks.

ChEBI ID: 65323

Members (21)

MemberDefinitionRole
akuammicineA monoterpenoid indole alkaloid with formula C20H22N2O2, isolated from several plant species including Alstonia spatulata, Catharanthus roseus and Vinca major.akuammicine
brucinebrucine
catharanthineAn organic heteropentacyclic compound and monoterpenoid indole alkaloid produced by the medicinal plant Catharanthus roseus via strictosidine.catharanthine
coronardineA monoterpenoid indole alkaloid with formula C21H26N2O2. It is isolated from the flowering plant genus, Tabernaemontana.(-)-coronaridine
ervatamineErvatamine
goniomitineGoniomitine
leuconolamLeuconolam
lundurine aLundurine A
methyl reserpateMethyl reserpate
mitragynineMitragynine
noribogaineAn organic heteropentacyclic compound that is ibogamine in which the indole hydrogen para to the indole nitrogen has been replaced by a hydroxy group. It is the primary (and long-lived) metabolite of ibogaine, the psychoactive indole alkaloid found in the African rainforest shrub Tabernanthe iboga.noribogaine
pleiocarpaminePleiocarpamine
quinineAn Aspidosperma alkaloid with molecular formula C21H24N2O3 found in the roots of Madagascar periwinkle (Catharanthus roseus, formerly known as Vinca rosea).lochnericine
raubasineA monoterpenoid indole alkaloid with formula C21H24N2O3, isolated from several Rauvolfia and Catharanthus species. It is a selective alpha1-adrenoceptor antagonist used for the treatment of high blood pressure.ajmalicine
stemmadenineA monoterpenoid indole alkaloid with formula C21H26N2O3, isolated from several plant species including Rhazya stricta, Tabernaemontana dichotoma and Aspidosperma pyricollum.15alpha-stemmadenine
strychnineA monoterpenoid indole alkaloid that is strychnidine bearing a keto substituent at the 10-position.strychnine
strychnine n-oxideA tertiary amine oxide resulting from the oxidation of the non-acylated nitrogen of strychnine. It is a metabolite of strychnine.strychnine N-oxide
tabersonineA monoterpenoid indole alkaloid with cytotoxic activity.tabersonine
vincosamideVincosamide
vindolinineA monoterpenoid indole alkaloid with formula C21H24N2O2, isolated from several plant species.vindolinine
voacamineA monoterpenoid indole alkaloid with formula C22H28N2O3, isolated from several plant species.(-)-voacangine

Research

Studies (4,885)

TimeframeStudies, Drugs in This Class (%)All Drugs %
pre-19902,525 (51.69)18.7374
1990's769 (15.74)18.2507
2000's721 (14.76)29.6817
2010's692 (14.17)24.3611
2020's178 (3.64)2.80

Study Types

Publication TypeStudies, Drugs in This Class (%)All Drugs (%)
Trials23 (0.41%)5.53%
Reviews153 (2.76%)6.00%
Case Studies118 (2.13%)4.05%
Observational1 (0.02%)0.25%
Other5,249 (94.68%)84.16%