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monoterpenoid indole alkaloid
A terpenoid indole alkaloid which is biosynthesised from L-tryptophan and diisoprenoid (usually secolaganin) building blocks.
ChEBI ID: 65323
Members (21)
| Member | Definition | Role |
|---|---|---|
| akuammicine | A monoterpenoid indole alkaloid with formula C20H22N2O2, isolated from several plant species including Alstonia spatulata, Catharanthus roseus and Vinca major. | akuammicine |
| brucine | brucine | |
| catharanthine | An organic heteropentacyclic compound and monoterpenoid indole alkaloid produced by the medicinal plant Catharanthus roseus via strictosidine. | catharanthine |
| coronardine | A monoterpenoid indole alkaloid with formula C21H26N2O2. It is isolated from the flowering plant genus, Tabernaemontana. | (-)-coronaridine |
| ervatamine | Ervatamine | |
| goniomitine | Goniomitine | |
| leuconolam | Leuconolam | |
| lundurine a | Lundurine A | |
| methyl reserpate | Methyl reserpate | |
| mitragynine | Mitragynine | |
| noribogaine | An organic heteropentacyclic compound that is ibogamine in which the indole hydrogen para to the indole nitrogen has been replaced by a hydroxy group. It is the primary (and long-lived) metabolite of ibogaine, the psychoactive indole alkaloid found in the African rainforest shrub Tabernanthe iboga. | noribogaine |
| pleiocarpamine | Pleiocarpamine | |
| quinine | An Aspidosperma alkaloid with molecular formula C21H24N2O3 found in the roots of Madagascar periwinkle (Catharanthus roseus, formerly known as Vinca rosea). | lochnericine |
| raubasine | A monoterpenoid indole alkaloid with formula C21H24N2O3, isolated from several Rauvolfia and Catharanthus species. It is a selective alpha1-adrenoceptor antagonist used for the treatment of high blood pressure. | ajmalicine |
| stemmadenine | A monoterpenoid indole alkaloid with formula C21H26N2O3, isolated from several plant species including Rhazya stricta, Tabernaemontana dichotoma and Aspidosperma pyricollum. | 15alpha-stemmadenine |
| strychnine | A monoterpenoid indole alkaloid that is strychnidine bearing a keto substituent at the 10-position. | strychnine |
| strychnine n-oxide | A tertiary amine oxide resulting from the oxidation of the non-acylated nitrogen of strychnine. It is a metabolite of strychnine. | strychnine N-oxide |
| tabersonine | A monoterpenoid indole alkaloid with cytotoxic activity. | tabersonine |
| vincosamide | Vincosamide | |
| vindolinine | A monoterpenoid indole alkaloid with formula C21H24N2O2, isolated from several plant species. | vindolinine |
| voacamine | A monoterpenoid indole alkaloid with formula C22H28N2O3, isolated from several plant species. | (-)-voacangine |
Research
Studies (4,885)
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 2,525 (51.69) | 18.7374 |
| 1990's | 769 (15.74) | 18.2507 |
| 2000's | 721 (14.76) | 29.6817 |
| 2010's | 692 (14.17) | 24.3611 |
| 2020's | 178 (3.64) | 2.80 |
Study Types
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 23 (0.41%) | 5.53% |
| Reviews | 153 (2.76%) | 6.00% |
| Case Studies | 118 (2.13%) | 4.05% |
| Observational | 1 (0.02%) | 0.25% |
| Other | 5,249 (94.68%) | 84.16% |