Any drug that acts on an alpha-adrenergic receptor.
ChEBI ID: 48539
| Member | Definition | Class |
|---|---|---|
| apomorphine | apomorphine | |
| zotepine | zotepine |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 4,828 (54.30) | 18.7374 |
| 1990's | 1,873 (21.07) | 18.2507 |
| 2000's | 1,285 (14.45) | 29.6817 |
| 2010's | 749 (8.42) | 24.3611 |
| 2020's | 156 (1.75) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 317 (3.38%) | 5.53% |
| Reviews | 430 (4.58%) | 6.00% |
| Case Studies | 139 (1.48%) | 4.05% |
| Observational | 12 (0.13%) | 0.25% |
| Other | 8,486 (90.43%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 3.9811 | 1 | 1 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 33.2656 | 3 | 4 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 30.3001 | 1 | 2 |
| AR protein | Homo sapiens (human) | Potency | 27.6560 | 6 | 11 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 4.3080 | 2 | 2 |
| Ataxin-2 | Homo sapiens (human) | Potency | 26.6032 | 1 | 1 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 12.5893 | 1 | 1 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 26.6032 | 1 | 1 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 33.4915 | 1 | 1 |
| caspase-3 | Homo sapiens (human) | Potency | 33.4915 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 15.1805 | 1 | 2 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 15.7142 | 2 | 2 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 12.5694 | 2 | 2 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 22.3342 | 1 | 1 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 0.2818 | 1 | 1 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 12.5694 | 2 | 2 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 8.2918 | 1 | 2 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 5.0119 | 2 | 2 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 6.6139 | 2 | 3 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 30.0474 | 1 | 2 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 21.7612 | 6 | 6 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 29.0170 | 2 | 3 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 29.6803 | 6 | 8 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 1.4125 | 1 | 1 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 33.4889 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 5.0119 | 1 | 1 |
| GALC protein | Homo sapiens (human) | Potency | 0.7079 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 5.0119 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 5.0119 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 5.0119 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 5.0119 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 5.0119 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 5.0119 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 5.0119 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 5.0119 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 5.0119 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 5.0119 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 5.0119 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 5.0119 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 5.0119 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 5.0119 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 5.0119 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 22.6919 | 2 | 2 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 22.7184 | 2 | 4 |
| GLS protein | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 28.4695 | 2 | 2 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 11.8832 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 19.1742 | 2 | 5 |
| histone deacetylase 9 isoform 3 | Homo sapiens (human) | Potency | 33.4915 | 1 | 1 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 33.3244 | 2 | 2 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 26.8325 | 1 | 1 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 25.1189 | 1 | 1 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 11.4239 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 22.9364 | 2 | 4 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 15.1951 | 2 | 2 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 30.1065 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 21.1183 | 2 | 3 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 14.0338 | 3 | 5 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 14.3818 | 1 | 1 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 12.8655 | 2 | 2 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 29.8470 | 1 | 1 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 44.9647 | 1 | 2 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 0.5012 | 1 | 1 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| progesterone receptor | Homo sapiens (human) | Potency | 28.6008 | 1 | 2 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 25.5580 | 2 | 3 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 0.0947 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 26.2323 | 3 | 6 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 20.5264 | 2 | 2 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 10.9740 | 1 | 2 |
| TDP1 protein | Homo sapiens (human) | Potency | 13.5969 | 2 | 6 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 16.4453 | 3 | 5 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 32.8670 | 3 | 3 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 14.6465 | 2 | 3 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 19.1498 | 1 | 2 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 11.8832 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 2 | 2 |
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | Ki | 0.2670 | 5 | 5 |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 2 | 2 |
| 5-hydroxytryptamine receptor 1D | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 2 | 2 |
| 5-hydroxytryptamine receptor 1F | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 2 | 2 |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 2 | 2 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | Ki | 0.0249 | 5 | 5 |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 2 | 2 |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 2 | 2 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | Ki | 0.0029 | 1 | 1 |
| 5-hydroxytryptamine receptor 3A | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 2 | 2 |
| 5-hydroxytryptamine receptor 3B | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 2 | 2 |
| 5-hydroxytryptamine receptor 4 | Rattus norvegicus (Norway rat) | IC50 | 7.1167 | 3 | 3 |
| 5-hydroxytryptamine receptor 5A | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 2 | 2 |
| 5-hydroxytryptamine receptor 5B | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 2 | 2 |
| 5-hydroxytryptamine receptor 6 | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 2 | 2 |
| 5-hydroxytryptamine receptor 7 | Cavia porcellus (domestic guinea pig) | IC50 | 20.8000 | 1 | 2 |
| 5-hydroxytryptamine receptor 7 | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 2 | 2 |
| 5-hydroxytryptamine receptor 7 | Rattus norvegicus (Norway rat) | Ki | 0.1880 | 3 | 3 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 7.7500 | 1 | 1 |
| Alpha-1A adrenergic receptor | Homo sapiens (human) | Ki | 0.0034 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.3300 | 1 | 1 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 7.7500 | 1 | 1 |
| Alpha-1B adrenergic receptor | Homo sapiens (human) | Ki | 0.0034 | 1 | 1 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.3300 | 1 | 1 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 7.7500 | 1 | 1 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | Ki | 0.0034 | 1 | 1 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.3300 | 1 | 1 |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0630 | 1 | 1 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | Ki | 0.5700 | 2 | 2 |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0630 | 1 | 1 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | Ki | 0.5700 | 2 | 2 |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0630 | 1 | 1 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | Ki | 0.5700 | 2 | 2 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 159.8333 | 3 | 3 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| D | Bos taurus (cattle) | IC50 | 0.3385 | 11 | 13 |
| D | Rattus norvegicus (Norway rat) | IC50 | 0.4744 | 12 | 12 |
| D | Bos taurus (cattle) | Ki | 0.0037 | 1 | 1 |
| D | Mus musculus (house mouse) | Ki | 0.1010 | 1 | 1 |
| D | Rattus norvegicus (Norway rat) | Ki | 0.3862 | 8 | 8 |
| D(1A) dopamine receptor | Homo sapiens (human) | IC50 | 0.0250 | 1 | 1 |
| D(1A) dopamine receptor | Homo sapiens (human) | Ki | 0.2726 | 10 | 10 |
| D(1B) dopamine receptor | Homo sapiens (human) | IC50 | 0.0250 | 1 | 1 |
| D(1B) dopamine receptor | Rattus norvegicus (Norway rat) | IC50 | 0.1432 | 7 | 7 |
| D(1B) dopamine receptor | Homo sapiens (human) | Ki | 0.0150 | 1 | 1 |
| D(2) dopamine receptor | Bos taurus (cattle) | IC50 | 0.3385 | 11 | 13 |
| D(2) dopamine receptor | Homo sapiens (human) | IC50 | 0.0146 | 2 | 2 |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0813 | 16 | 19 |
| D(2) dopamine receptor | Bos taurus (cattle) | Ki | 0.1019 | 2 | 2 |
| D(2) dopamine receptor | Homo sapiens (human) | Ki | 0.0554 | 22 | 22 |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | Ki | 0.0244 | 11 | 12 |
| D(3) dopamine receptor | Homo sapiens (human) | IC50 | 0.0250 | 1 | 1 |
| D(3) dopamine receptor | Rattus norvegicus (Norway rat) | IC50 | 0.1432 | 7 | 7 |
| D(3) dopamine receptor | Homo sapiens (human) | Ki | 0.0100 | 6 | 6 |
| D(4) dopamine receptor | Homo sapiens (human) | IC50 | 0.0250 | 1 | 1 |
| D(4) dopamine receptor | Rattus norvegicus (Norway rat) | IC50 | 0.1432 | 7 | 7 |
| D(4) dopamine receptor | Homo sapiens (human) | Ki | 0.0290 | 3 | 3 |
| E3 ubiquitin-protein ligase Mdm2 | Homo sapiens (human) | IC50 | 10.1367 | 3 | 3 |
| Histamine H1 receptor | Homo sapiens (human) | Ki | 0.0020 | 2 | 2 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | Ki | 0.5500 | 1 | 1 |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | Ki | 0.0005 | 1 | 1 |
| Solute carrier family 22 member 1 | Homo sapiens (human) | IC50 | 20.8000 | 1 | 1 |
| Tryptophan 5-hydroxylase 1 | Rattus norvegicus (Norway rat) | IC50 | 0.2200 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| D(1A) dopamine receptor | Homo sapiens (human) | EC50 | 0.1846 | 4 | 6 |
| D(1A) dopamine receptor | Homo sapiens (human) | Kd | 0.6800 | 1 | 1 |
| D(2) dopamine receptor | Homo sapiens (human) | EC50 | 0.0544 | 10 | 12 |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | EC50 | 0.0171 | 5 | 5 |
| D(2) dopamine receptor | Homo sapiens (human) | Kd | 0.0240 | 1 | 1 |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | Kd | 0.7600 | 4 | 5 |
| D(3) dopamine receptor | Homo sapiens (human) | EC50 | 0.0070 | 1 | 1 |
| D(4) dopamine receptor | Homo sapiens (human) | EC50 | 0.0043 | 2 | 2 |
| D(4) dopamine receptor | Rattus norvegicus (Norway rat) | EC50 | 0.0042 | 3 | 3 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| D(1A) dopamine receptor | Homo sapiens (human) | ID50 | 0.0390 | 1 | 1 |
| D(1A) dopamine receptor | Homo sapiens (human) | KL | 0.2060 | 1 | 1 |
| D(1B) dopamine receptor | Homo sapiens (human) | ID50 | 0.0390 | 1 | 1 |
| D(2) dopamine receptor | Homo sapiens (human) | ID50 | 0.0390 | 1 | 1 |
| D(2) dopamine receptor | Homo sapiens (human) | KL | 0.1665 | 2 | 2 |
| D(3) dopamine receptor | Homo sapiens (human) | ID50 | 0.0390 | 1 | 1 |
| D(4) dopamine receptor | Homo sapiens (human) | ID50 | 0.0390 | 1 | 1 |