Page last updated: 2024-08-05 15:42:19

retinoid X receptor agonist

An agonist that selectively binds to and activates a retinoid X receptor.

ChEBI ID: 63794

Members (2)

MemberDefinitionClass
alitretinoinA retinoic acid in which the exocyclic double bonds have 7E,9Z,11E,13E geometry.9-cis-retinoic acid
tretinoinA retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.all-trans-retinoic acid

Research

Studies (22,912)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-19903,534 (15.42)18.7374
1990's6,541 (28.55)18.2507
2000's6,060 (26.45)29.6817
2010's5,326 (23.25)24.3611
2020's1,451 (6.33)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials1,130 (4.61%)5.53%
Reviews2,037 (8.31%)6.00%
Case Studies1,440 (5.88%)4.05%
Observational21 (0.09%)0.25%
Other19,880 (81.12%)84.16%

Protein Targets (152)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
acetylcholinesteraseHomo sapiens (human)Potency89.358411
activating transcription factor 6Homo sapiens (human)Potency58.299312
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency31.920415
AR proteinHomo sapiens (human)Potency13.8260717
aryl hydrocarbon receptorHomo sapiens (human)Potency39.115023
Ataxin-2Homo sapiens (human)Potency27.412212
ATP-dependent phosphofructokinaseTrypanosoma brucei brucei TREU927Potency33.807811
ATPase family AAA domain-containing protein 5Homo sapiens (human)Potency31.144823
Bloom syndrome protein isoform 1Homo sapiens (human)Potency0.022422
bromodomain adjacent to zinc finger domain 2BHomo sapiens (human)Potency79.432811
caspase-3Cricetulus griseus (Chinese hamster)Potency68.519911
Caspase-7Cricetulus griseus (Chinese hamster)Potency68.519911
Cellular tumor antigen p53Homo sapiens (human)Potency58.475625
Chain A, 2-oxoglutarate OxygenaseHomo sapiens (human)Potency28.183811
Chain A, ATP-DEPENDENT DNA HELICASE Q1Homo sapiens (human)Potency39.810711
Chain A, Beta-lactamaseEscherichia coli K-12Potency8.912511
Chain A, CruzipainTrypanosoma cruziPotency37.081413
Chain A, Ferritin light chainEquus caballus (horse)Potency29.903322
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency0.005611
chromobox protein homolog 1Homo sapiens (human)Potency39.810711
cytochrome P450 2C9, partialHomo sapiens (human)Potency27.540411
cytochrome P450 3A4 isoform 1Homo sapiens (human)Potency39.810722
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency19.497111
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency29.849311
DNA polymerase kappa isoform 1Homo sapiens (human)Potency31.622811
estrogen nuclear receptor alphaHomo sapiens (human)Potency7.81701136
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency31.109227
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency13.15971024
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency33.543515
farnesoid X nuclear receptorHomo sapiens (human)Potency28.386049
GVesicular stomatitis virusPotency27.540411
GABA theta subunitRattus norvegicus (Norway rat)Potency39.810711
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)Potency39.810711
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)Potency39.810711
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)Potency39.810711
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)Potency39.810711
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)Potency39.810711
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)Potency39.810711
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)Potency39.810711
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)Potency39.810711
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)Potency39.810711
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)Potency39.810711
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)Potency39.810711
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)Potency39.810711
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)Potency39.810711
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)Potency39.810711
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)Potency39.810711
gemininHomo sapiens (human)Potency30.705122
GLI family zinc finger 3Homo sapiens (human)Potency15.179339
GLS proteinHomo sapiens (human)Potency0.251211
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency58.307912
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency0.172714
heat shock protein beta-1Homo sapiens (human)Potency49.642826
histone acetyltransferase KAT2A isoform 1Homo sapiens (human)Potency31.622811
Histone H2A.xCricetulus griseus (Chinese hamster)Potency100.715011
HLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)Potency27.540411
hypoxia-inducible factor 1 alpha subunitHomo sapiens (human)Potency55.824725
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)Homo sapiens (human)Potency0.251222
Inositol hexakisphosphate kinase 1Homo sapiens (human)Potency27.540412
Interferon betaHomo sapiens (human)Potency27.540411
LuciferasePhotinus pyralis (common eastern firefly)Potency45.807725
M-phase phosphoprotein 8Homo sapiens (human)Potency19.952611
Microtubule-associated protein tauHomo sapiens (human)Potency29.715929
nonstructural protein 1Influenza A virus (A/WSN/1933(H1N1))Potency7.079511
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency33.0571410
nuclear factor erythroid 2-related factor 2 isoform 2Homo sapiens (human)Potency3.264311
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency6.778614
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency25.8158312
ParkinHomo sapiens (human)Potency3.662611
peripheral myelin protein 22Rattus norvegicus (Norway rat)Potency0.199411
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency12.1307412
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency20.081636
phosphopantetheinyl transferaseBacillus subtilisPotency79.432811
pregnane X nuclear receptorHomo sapiens (human)Potency44.751726
pregnane X receptorRattus norvegicus (Norway rat)Potency37.618812
progesterone receptorHomo sapiens (human)Potency34.919022
RAR-related orphan receptor gammaMus musculus (house mouse)Potency13.679928
regulator of G-protein signaling 4Homo sapiens (human)Potency26.679511
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency10.0452311
retinoid X nuclear receptor alphaHomo sapiens (human)Potency0.3887310
SMAD family member 2Homo sapiens (human)Potency54.941011
SMAD family member 3Homo sapiens (human)Potency54.941011
survival motor neuron protein isoform dHomo sapiens (human)Potency0.794311
TDP1 proteinHomo sapiens (human)Potency15.980629
thioredoxin glutathione reductaseSchistosoma mansoniPotency35.481311
thioredoxin reductaseRattus norvegicus (Norway rat)Potency23.962523
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency27.4386311
thyroid hormone receptor beta isoform aHomo sapiens (human)Potency0.002811
thyroid stimulating hormone receptorHomo sapiens (human)Potency34.582435
thyrotropin-releasing hormone receptorHomo sapiens (human)Potency37.911711
USP1 protein, partialHomo sapiens (human)Potency67.833412
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency31.622811
vitamin D3 receptor isoform VDRAHomo sapiens (human)Potency48.922414
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency0.172714

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
10 kDa chaperonin Escherichia coliIC5013.850022
10 kDa heat shock protein, mitochondrialHomo sapiens (human)IC505.300011
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)Ki0.000511
5-hydroxytryptamine receptor 2BHomo sapiens (human)IC500.358011
5-hydroxytryptamine receptor 2BHomo sapiens (human)Ki0.228011
60 kDa chaperoninEscherichia coli K-12IC50250.000011
60 kDa chaperonin Escherichia coliIC5013.850022
60 kDa heat shock protein, mitochondrialHomo sapiens (human)IC505.300011
Adenosine receptor A3Homo sapiens (human)IC505.275011
Adenosine receptor A3Homo sapiens (human)Ki2.982011
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)IC505.275011
Alpha-1A adrenergic receptorBos taurus (cattle)Ki0.000411
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)Ki0.745824
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)IC505.275011
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)Ki0.745824
Alpha-1D adrenergic receptorRattus norvegicus (Norway rat)Ki0.000413
Alpha-synucleinHomo sapiens (human)IC503.000011
Amyloid-beta precursor proteinHomo sapiens (human)IC500.180011
ATP-binding cassette sub-family C member 3Homo sapiens (human)IC50133.000011
Bile salt export pumpHomo sapiens (human)IC5071.500022
Canalicular multispecific organic anion transporter 1Homo sapiens (human)IC50133.000011
Cellular retinoic acid-binding protein 1Gallus gallus (chicken)IC502.892544
Chain A, Nuclear Receptor ROR-betaRattus norvegicus (Norway rat)Ki0.280011
Cytochrome P450 1A2Homo sapiens (human)Ki0.583011
Indoleamine 2,3-dioxygenase 1Mus musculus (house mouse)IC50301.300011
Indoleamine 2,3-dioxygenase 2Mus musculus (house mouse)IC5028.700011
Mitogen-activated protein kinase 1Homo sapiens (human)IC500.576011
Multidrug resistance-associated protein 4Homo sapiens (human)IC50133.000011
Nuclear receptor ROR-alphaHomo sapiens (human)IC500.199511
Nuclear receptor ROR-betaHomo sapiens (human)IC5012.622422
Nuclear receptor ROR-gammaHomo sapiens (human)IC500.199511
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1Homo sapiens (human)IC500.820011
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1Homo sapiens (human)Ki0.820011
Retinoic acid receptor alphaHomo sapiens (human)IC501.804745
Retinoic acid receptor alphaMus musculus (house mouse)IC500.012034
Retinoic acid receptor alphaHomo sapiens (human)Ki0.057234
retinoic acid receptor alpha isoform 1Homo sapiens (human)IC500.008411
Retinoic acid receptor betaHomo sapiens (human)IC500.604445
Retinoic acid receptor betaMus musculus (house mouse)IC500.005022
Retinoic acid receptor betaHomo sapiens (human)Ki0.009834
Retinoic acid receptor gammaMus musculus (house mouse)IC500.004022
Retinoic acid receptor gamma Homo sapiens (human)IC500.009034
Retinoic acid receptor gamma Homo sapiens (human)Ki0.007246
Retinoic acid receptor RXR-alphaHomo sapiens (human)IC500.353723
Retinoic acid receptor RXR-alphaMus musculus (house mouse)IC5013.520534
Retinoic acid receptor RXR-alphaHomo sapiens (human)Ki0.221278
retinoic acid receptor RXR-alpha isoform aHomo sapiens (human)IC500.018911
Retinoic acid receptor RXR-betaHomo sapiens (human)IC500.506012
Retinoic acid receptor RXR-betaMus musculus (house mouse)IC5050.000011
Retinoic acid receptor RXR-betaHomo sapiens (human)Ki0.159346
Retinoic acid receptor RXR-gammaHomo sapiens (human)IC500.177012
Retinoic acid receptor RXR-gammaMus musculus (house mouse)IC5050.000011
Retinoic acid receptor RXR-gammaHomo sapiens (human)Ki0.074646
Thiosulfate sulfurtransferaseHomo sapiens (human)IC5091.000011

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Cellular retinoic acid-binding protein 1Mus musculus (house mouse)Kd0.066923
Cellular retinoic acid-binding protein 2Mus musculus (house mouse)Kd0.068033
Cytochrome P450 1A2Homo sapiens (human)EC500.000511
Cytochrome P450 2C19Homo sapiens (human)EC500.000611
Cytochrome P450 2C9 Homo sapiens (human)EC500.001211
Cytochrome P450 2D6Homo sapiens (human)EC500.000211
Cytochrome P450 3A4Homo sapiens (human)EC500.001511
Nuclear receptor ROR-gammaHomo sapiens (human)EC5016.000012
Nuclear receptor subfamily 4 group A member 1Homo sapiens (human)Kd0.810011
Oxysterols receptor LXR-alphaHomo sapiens (human)EC501.090011
Oxysterols receptor LXR-betaHomo sapiens (human)EC501.730011
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1Homo sapiens (human)Kd0.800011
ReninHomo sapiens (human)EC500.003311
Retinoic acid receptor alphaHomo sapiens (human)EC500.15052228
Retinoic acid receptor alphaMus musculus (house mouse)EC500.008233
Retinoic acid receptor alphaHomo sapiens (human)Kd0.02221118
Retinoic acid receptor alphaMus musculus (house mouse)Kd0.011012
Retinoic acid receptor betaHomo sapiens (human)EC500.03102228
Retinoic acid receptor betaMus musculus (house mouse)EC500.001233
Retinoic acid receptor betaHomo sapiens (human)Kd0.02141219
Retinoic acid receptor betaMus musculus (house mouse)Kd0.010012
Retinoic acid receptor gammaMus musculus (house mouse)EC500.000422
Retinoic acid receptor gammaMus musculus (house mouse)Kd0.017512
Retinoic acid receptor gamma Homo sapiens (human)EC500.01781824
Retinoic acid receptor gamma Homo sapiens (human)Kd0.02821321
Retinoic acid receptor RXR-alphaHomo sapiens (human)EC500.27241422
Retinoic acid receptor RXR-alphaMus musculus (house mouse)EC501.100022
Retinoic acid receptor RXR-alphaRattus norvegicus (Norway rat)EC500.115022
Retinoic acid receptor RXR-alphaHomo sapiens (human)Kd0.21411520
Retinoic acid receptor RXR-alphaMus musculus (house mouse)Kd0.516012
Retinoic acid receptor RXR-betaHomo sapiens (human)EC500.4836610
Retinoic acid receptor RXR-betaMus musculus (house mouse)EC500.669512
Retinoic acid receptor RXR-betaHomo sapiens (human)Kd0.016723
Retinoic acid receptor RXR-betaMus musculus (house mouse)Kd0.333224
Retinoic acid receptor RXR-gammaHomo sapiens (human)EC500.437259
Retinoic acid receptor RXR-gammaMus musculus (house mouse)EC500.363723
Retinoic acid receptor RXR-gammaHomo sapiens (human)Kd0.072835
Retinoic acid receptor RXR-gammaMus musculus (house mouse)Kd0.177012
Type-1 angiotensin II receptorOryctolagus cuniculus (rabbit)Kd0.050011
Type-2 angiotensin II receptorHomo sapiens (human)Kd0.042522

Other Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Cellular retinoic acid-binding protein 1Gallus gallus (chicken)ID501.000011
Ornithine decarboxylaseMus musculus (house mouse)ID500.000111
Ornithine decarboxylaseRattus norvegicus (Norway rat)ID500.000011
Retinoic acid receptor alphaHomo sapiens (human)AC500.019011
Retinoic acid receptor alphaHomo sapiens (human)EC300.001022
Retinoic acid receptor alphaHomo sapiens (human)Relative EC300.002222
Retinoic acid receptor alphaHomo sapiens (human)Relative IC500.000922
Retinoic acid receptor betaHomo sapiens (human)AC500.002011
Retinoic acid receptor betaHomo sapiens (human)EC300.000822
Retinoic acid receptor betaHomo sapiens (human)Relative EC300.001622
Retinoic acid receptor betaHomo sapiens (human)Relative IC500.000722
Retinoic acid receptor gamma Homo sapiens (human)AC500.003011
Retinoic acid receptor gamma Homo sapiens (human)EC300.000222
Retinoic acid receptor gamma Homo sapiens (human)Relative EC300.000622
Retinoic acid receptor gamma Homo sapiens (human)Relative IC500.000722
Retinoic acid receptor RXR-alphaHomo sapiens (human)AC500.007011
Retinoic acid receptor RXR-alphaHomo sapiens (human)Activity3.450011