metal ion binding

Definition

Target type: molecularfunction

Binding to a metal ion. [GOC:ai]

Metal ion binding is a fundamental molecular function that involves the interaction of a protein or other biomolecule with a metal ion. This interaction can occur through a variety of mechanisms, including electrostatic interactions, coordinate bonds, and hydrophobic interactions. The specific nature of the metal ion binding site and the type of metal ion bound can vary widely, leading to a diverse range of functions.

Metal ion binding plays crucial roles in many biological processes, including:

* **Enzymatic catalysis:** Metal ions can act as cofactors in enzymatic reactions, facilitating the formation of reactive intermediates, stabilizing transition states, or promoting electron transfer.
* **Structural integrity:** Metal ions can contribute to the overall stability and structure of proteins and other biomolecules by forming cross-links or bridging interactions.
* **Signal transduction:** Metal ions can act as signaling molecules, binding to specific receptors and triggering downstream signaling pathways.
* **Transport and storage:** Metal ions are involved in the transport and storage of essential nutrients and other molecules within cells and organisms.
* **Gene regulation:** Metal ions can influence gene expression by binding to regulatory proteins and altering their activity.

The specific molecular function of metal ion binding is highly dependent on the identity of the metal ion, the protein or biomolecule involved, and the context of the interaction. For example, zinc ions are often involved in catalytic activities, while calcium ions are essential for signal transduction.

Metal ion binding is a complex and multifaceted process that is essential for life. Understanding the molecular basis of metal ion binding is crucial for understanding the function of many proteins and other biomolecules, as well as for developing new therapeutic strategies.'
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Proteins (453)

Compounds (3,743)