Page last updated: 2024-08-05 15:45:41

EC 2.3.1.5 (arylamine N-acetyltransferase) inhibitor

An EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor that interferes with the action of arylamine N-acetyltransferase (EC 2.3.1.5).

ChEBI ID: 84799

Members (1)

MemberDefinitionClass
ellagic acidAn organic heterotetracyclic compound resulting from the formal dimerisation of gallic acid by oxidative aromatic coupling with intramolecular lactonisation of both carboxylic acid groups of the resulting biaryl. It is found in many fruits and vegetables, including raspberries, strawberries, cranberries, and pomegranates.ellagic acid

Research

Studies (1,520)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-1990119 (7.83)18.7374
1990's108 (7.11)18.2507
2000's266 (17.50)29.6817
2010's673 (44.28)24.3611
2020's354 (23.29)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials25 (1.57%)5.53%
Reviews86 (5.41%)6.00%
Case Studies1 (0.06%)4.05%
Observational1 (0.06%)0.25%
Other1,478 (92.90%)84.16%

Protein Targets (190)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1Homo sapiens (human)Potency0.636213
15-lipoxygenase, partialHomo sapiens (human)Potency5.011911
apical membrane antigen 1, AMA1Plasmodium falciparum 3D7Potency0.794311
ATP-dependent phosphofructokinaseTrypanosoma brucei brucei TREU927Potency16.944111
Bloom syndrome protein isoform 1Homo sapiens (human)Potency6.322113
bromodomain adjacent to zinc finger domain 2BHomo sapiens (human)Potency0.794311
cellular tumor antigen p53 isoform aHomo sapiens (human)Potency22.106012
Chain A, 2-oxoglutarate OxygenaseHomo sapiens (human)Potency3.461913
Chain A, ATP-DEPENDENT DNA HELICASE Q1Homo sapiens (human)Potency1.223324
Chain A, Beta-lactamaseEscherichia coli K-12Potency56.234111
Chain A, HADH2 proteinHomo sapiens (human)Potency1.666123
Chain A, JmjC domain-containing histone demethylation protein 3AHomo sapiens (human)Potency0.707911
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency7.063434
Chain A, Putative fructose-1,6-bisphosphate aldolaseGiardia intestinalisPotency9.998224
Chain A, TYROSYL-DNA PHOSPHODIESTERASEHomo sapiens (human)Potency0.056224
Chain B, HADH2 proteinHomo sapiens (human)Potency1.666123
chromobox protein homolog 1Homo sapiens (human)Potency1.000011
core-binding factor subunit beta isoform 2Homo sapiens (human)Potency0.360422
cytochrome P450 2C19 precursorHomo sapiens (human)Potency31.622811
cytochrome P450 2C9 precursorHomo sapiens (human)Potency39.810711
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency2.131711
DNA polymerase betaHomo sapiens (human)Potency0.158511
DNA polymerase eta isoform 1Homo sapiens (human)Potency0.794311
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency0.611012
DNA polymerase kappa isoform 1Homo sapiens (human)Potency0.390513
endonuclease IVEscherichia coliPotency19.952611
estrogen nuclear receptor alphaHomo sapiens (human)Potency23.710111
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency1.258911
flap endonuclease 1Homo sapiens (human)Potency36.189812
fructose-bisphosphate aldolase AOryctolagus cuniculus (rabbit)Potency63.095711
gemininHomo sapiens (human)Potency15.621522
GLS proteinHomo sapiens (human)Potency2.818411
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency2.683211
Glutamate receptor 1Rattus norvegicus (Norway rat)Potency0.014111
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency0.014111
Glutamate receptor 3Rattus norvegicus (Norway rat)Potency0.014111
Glutamate receptor 4Rattus norvegicus (Norway rat)Potency0.014111
glyceraldehyde-3-phosphate dehydrogenase isoform 1Homo sapiens (human)Potency79.432811
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)Homo sapiens (human)Potency22.387211
hemoglobin subunit betaHomo sapiens (human)Potency10.000011
Histamine H2 receptorCavia porcellus (domestic guinea pig)Potency19.224227
histone acetyltransferase KAT2A isoform 1Homo sapiens (human)Potency25.118911
Histone H2A.xCricetulus griseus (Chinese hamster)Potency19.084311
histone-lysine N-methyltransferase 2A isoform 2 precursorHomo sapiens (human)Potency11.220211
IDH1Homo sapiens (human)Potency0.130011
importin subunit beta-1 isoform 1Homo sapiens (human)Potency15.848911
Inositol monophosphatase 1Rattus norvegicus (Norway rat)Potency15.848911
lamin isoform A-delta10Homo sapiens (human)Potency3.981111
lethal factor (plasmid)Bacillus anthracis str. A2012Potency1.000011
LuciferasePhotinus pyralis (common eastern firefly)Potency23.148133
lysosomal alpha-glucosidase preproproteinHomo sapiens (human)Potency4.466811
Microtubule-associated protein tauHomo sapiens (human)Potency26.002826
mitogen-activated protein kinase 1Homo sapiens (human)Potency19.952611
muscleblind-like protein 1 isoform 1Homo sapiens (human)Potency79.432811
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency0.584222
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency35.481311
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1Homo sapiens (human)Potency1.258911
phosphoglycerate kinaseTrypanosoma brucei brucei TREU927Potency0.891311
phosphopantetheinyl transferaseBacillus subtilisPotency79.432812
Polyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)Potency3.784212
Rap guanine nucleotide exchange factor 3Homo sapiens (human)Potency10.000011
Rap guanine nucleotide exchange factor 4Homo sapiens (human)Potency19.952611
RAR-related orphan receptor gammaMus musculus (house mouse)Potency12.990011
regulator of G-protein signaling 4Homo sapiens (human)Potency79.432811
runt-related transcription factor 1 isoform AML1bHomo sapiens (human)Potency0.360422
serine-protein kinase ATM isoform aHomo sapiens (human)Potency19.952611
serine/threonine-protein kinase PLK1Homo sapiens (human)Potency8.436811
snurportin-1Homo sapiens (human)Potency15.848911
Spike glycoproteinSevere acute respiratory syndrome-related coronavirusPotency19.952611
TDP1 proteinHomo sapiens (human)Potency29.092911
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency11.883211
thyroid hormone receptor beta isoform aHomo sapiens (human)Potency32.464812
ubiquitin carboxyl-terminal hydrolase 2 isoform aHomo sapiens (human)Potency1.122011
USP1 protein, partialHomo sapiens (human)Potency50.451222
vitamin D3 receptor isoform VDRAHomo sapiens (human)Potency39.810711

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
5'-nucleotidaseHomo sapiens (human)IC501.850011
5'-nucleotidaseMus musculus (house mouse)IC500.040011
acetyl-CoA acetyltransferase/HMG-CoA reductaseEnterococcus faecalisIC501,265.390011
AcetylcholinesteraseElectrophorus electricus (electric eel)IC50132.920011
Adenosine receptor A1Rattus norvegicus (Norway rat)Ki10.570033
Adenosine receptor A2aRattus norvegicus (Norway rat)Ki7.615022
Aldehyde oxidase 1Cavia porcellus (domestic guinea pig)Ki4.530011
Aldo-keto reductase family 1 member B1Homo sapiens (human)IC500.200011
ALK tyrosine kinase receptorHomo sapiens (human)IC5040.000011
Amyloid-beta precursor proteinHomo sapiens (human)IC50200.000022
Angiopoietin-1 receptorHomo sapiens (human)IC500.260011
Angiotensin-converting enzyme Homo sapiens (human)IC505,000.000011
Aurora kinase AHomo sapiens (human)IC502.480011
Aurora kinase BHomo sapiens (human)IC502.500011
Beta-secretase 1Homo sapiens (human)IC503.900011
Bifunctional epoxide hydrolase 2Homo sapiens (human)IC5020.700011
cAMP-dependent protein kinase catalytic subunit alphaBos taurus (cattle)IC500.600011
cAMP-dependent protein kinase catalytic subunit alphaHomo sapiens (human)IC502.050022
cAMP-dependent protein kinase catalytic subunit betaHomo sapiens (human)IC502.050022
cAMP-dependent protein kinase catalytic subunit gammaHomo sapiens (human)IC502.050022
Carbonic anhydrase 1Homo sapiens (human)Ki105.880034
Carbonic anhydrase 12Homo sapiens (human)Ki9.125022
Carbonic anhydrase 13Homo sapiens (human)Ki4.240011
Carbonic anhydrase 13Mus musculus (house mouse)Ki10.300011
Carbonic anhydrase 14Homo sapiens (human)Ki8.910011
Carbonic anhydrase 2Homo sapiens (human)Ki113.795034
Carbonic anhydrase 3Homo sapiens (human)Ki10.500011
Carbonic anhydrase 4Homo sapiens (human)Ki9.080011
Carbonic anhydrase 5A, mitochondrialHomo sapiens (human)Ki7.590011
Carbonic anhydrase 5B, mitochondrialHomo sapiens (human)Ki12.700011
Carbonic anhydrase 6Homo sapiens (human)Ki7.060011
Carbonic anhydrase 7Homo sapiens (human)Ki7.555022
Carbonic anhydrase 9Homo sapiens (human)Ki44.585022
Casein kinase II subunit alphaHomo sapiens (human)IC500.040033
Casein kinase II subunit alphaHomo sapiens (human)Ki0.020011
Casein kinase II subunit alpha Rattus norvegicus (Norway rat)IC500.040011
Casein kinase II subunit alpha'Homo sapiens (human)IC500.040022
Casein kinase II subunit betaHomo sapiens (human)IC500.040022
Casein kinase II subunit betaRattus norvegicus (Norway rat)IC500.040011
Chain A, Casein kinase II subunit alphaHomo sapiens (human)Ki0.020011
CruzipainTrypanosoma cruziIC50142.000022
Cyclin-A1Homo sapiens (human)IC503.390011
Cyclin-A2Homo sapiens (human)IC503.390011
Cyclin-dependent kinase 2Homo sapiens (human)IC503.390011
Cyclin-dependent kinase 4Homo sapiens (human)IC501.090011
Cysteine protease ATG4BHomo sapiens (human)IC504.250022
Cytochrome P450 2D6Homo sapiens (human)IC504.770011
Cytochrome P450 2D6Homo sapiens (human)Ki1.950011
DNA dC->dU-editing enzyme APOBEC-3G isoform 1Homo sapiens (human)IC500.450011
DNA polymerase etaHomo sapiens (human)IC500.062011
DNA polymerase iotaHomo sapiens (human)IC500.062011
DNA primaseMycobacterium tuberculosis CDC1551IC50100.000011
dual specificity protein phosphatase 3Homo sapiens (human)IC501.105022
dual specificity protein phosphatase 6Rattus norvegicus (Norway rat)IC5039.500011
Dual specificity tyrosine-phosphorylation-regulated kinase 1AHomo sapiens (human)IC5040.000011
Ectonucleoside triphosphate diphosphohydrolase 1Mus musculus (house mouse)IC500.500011
ELAV-like protein 3Homo sapiens (human)IC500.600011
Ephrin type-B receptor 4Homo sapiens (human)IC501.830011
Epidermal growth factor receptorHomo sapiens (human)IC500.690011
eukaryotic translation initiation factor 4 gamma 1 isoform 4Homo sapiens (human)IC5047.671411
eukaryotic translation initiation factor 4E isoform 1Mus musculus (house mouse)IC5047.671411
Focal adhesion kinase 1Homo sapiens (human)IC503.110011
G-protein coupled receptor 35Homo sapiens (human)IC500.100011
G1/S-specific cyclin-D1Homo sapiens (human)IC501.090011
Glutathione reductase, mitochondrialHomo sapiens (human)IC5022.800011
Glutathione S-transferasePlasmodium falciparum 3D7IC5074.400011
Glutathione S-transferase Mu 1Mus musculus (house mouse)IC50100.000011
Glutathione S-transferase PHomo sapiens (human)IC5063.550022
Glycogen synthase kinase-3 betaHomo sapiens (human)IC507.500011
heat shock 70kDa protein 1AHomo sapiens (human)IC5066.920033
heat shock cognate 71 kDa protein isoform 1Homo sapiens (human)IC5099.600022
heat shock cognate 71 kDa protein isoform 2Homo sapiens (human)IC5099.600022
Hepatocyte growth factor receptorHomo sapiens (human)IC500.580011
Inhibitor of nuclear factor kappa-B kinase subunit betaHomo sapiens (human)IC501.980011
Insulin receptorHomo sapiens (human)IC500.340011
Insulin-like growth factor 1 receptorHomo sapiens (human)IC500.250011
Integrase Human immunodeficiency virus 1IC505.100022
likely tRNA 2'-phosphotransferaseCandida albicans SC5314IC500.291322
M17 leucyl aminopeptidasePlasmodium falciparum 3D7IC50138.080011
Macrophage migration inhibitory factorHomo sapiens (human)IC504.770011
Macrophage migration inhibitory factorHomo sapiens (human)Ki1.950011
Mcl-1Homo sapiens (human)IC5027.285022
Mitogen-activated protein kinase kinase kinase 8Homo sapiens (human)IC502.370011
mothers against decapentaplegic homolog 3 isoform 1Homo sapiens (human)IC500.142011
Muscarinic acetylcholine receptor M1Rattus norvegicus (Norway rat)IC500.570014
Muscarinic acetylcholine receptor M2Rattus norvegicus (Norway rat)IC500.570013
Muscarinic acetylcholine receptor M3Rattus norvegicus (Norway rat)IC500.570013
Muscarinic acetylcholine receptor M4Rattus norvegicus (Norway rat)IC500.570013
Muscarinic acetylcholine receptor M5Rattus norvegicus (Norway rat)IC500.570013
NUAK family SNF1-like kinase 1Homo sapiens (human)IC500.510011
NucleophosminHomo sapiens (human)IC5040.000011
Platelet-derived growth factor receptor betaHomo sapiens (human)IC501.300011
Polypeptide N-acetylgalactosaminyltransferase 2Homo sapiens (human)IC501.720022
Proto-oncogene tyrosine-protein kinase receptor RetHomo sapiens (human)IC5040.000011
Proto-oncogene tyrosine-protein kinase SrcHomo sapiens (human)IC500.466733
RAC-alpha serine/threonine-protein kinaseHomo sapiens (human)IC503.340011
Receptor tyrosine-protein kinase erbB-2Homo sapiens (human)IC503.540011
Receptor-type tyrosine-protein kinase FLT3Homo sapiens (human)IC5040.000011
ReninHomo sapiens (human)IC500.980011
Serine/threonine-protein kinase B-rafHomo sapiens (human)IC501.760011
Serine/threonine-protein kinase PLK1Homo sapiens (human)IC503.340011
Serine/threonine-protein kinase PLK4Homo sapiens (human)IC502.970011
Solute carrier family 22 member 6Homo sapiens (human)IC500.270011
Squalene monooxygenase Rattus norvegicus (Norway rat)IC502.000011
TatHuman immunodeficiency virus 1IC501.669011
Thioredoxin reductase 1, cytoplasmicHomo sapiens (human)IC50176.800022
Thioredoxin reductase 2, mitochondrialHomo sapiens (human)IC50176.800022
Thioredoxin reductase 3Homo sapiens (human)IC50176.800022
Translin-associated protein XHomo sapiens (human)IC503.500011
Tyrosine-protein kinase FgrRattus norvegicus (Norway rat)IC503.500011
Tyrosine-protein kinase Lyn Rattus norvegicus (Norway rat)IC507.500011
unnamed protein productAspergillus oryzae RIB40IC5052.719522
Vascular endothelial growth factor receptor 2Homo sapiens (human)IC500.790011
Vascular endothelial growth factor receptor 3Homo sapiens (human)IC501.540011
VifHuman immunodeficiency virus 1IC500.450011

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Amine oxidase [flavin-containing] AHomo sapiens (human)EC501.600011
G-protein coupled receptor 35Homo sapiens (human)EC501.535022
Polypeptide N-acetylgalactosaminyltransferase 2Homo sapiens (human)Kd0.371011

Other Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
AcetylcholinesteraseElectrophorus electricus (electric eel)EC24250.000011
CholinesteraseEquus caballus (horse)EC16250.000011
LactoperoxidaseBos taurus (cattle)Km0.300011