Page last updated: 2024-11-04

tocopheroxy radical

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Description

tocopheroxy radical: RN given refers to radical ion (1+), (2R-(2R*(4R*,8R*)))-isomer; RN for cpd without isomeric designation not available 12/90 [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID2116
CHEMBL ID49563
CHEBI ID93909
SCHEMBL ID22303
SCHEMBL ID14315133
MeSH IDM0182042

Synonyms (153)

Synonym
113085-06-6
2h-1-benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, radical ion(1+), (2r-(2r*(4r*,8r*)))-
tocopheroxyl radical
tocopheroxy radical
(2r,8'r)-.alpha.-tocopherol
2h-1-benzopyran-6-ol,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, [2r-[2r*(4r*,8r*)]]-
.alpha.-tocopherol
d-.alpha.-tocopherol
5,8-trimethyltocol
.alpha.-tokoferol
nsc20812
(all-r)-.alpha.-tocopherol
KBIO1_000533
DIVK1C_000533
SDCCGMLS-0066634.P001
2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2h-chromen-6-ol
einecs 233-466-0
(+-)-alpha-tocopherol
6-chromanol, 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-
brn 0094012
ccris 5853
2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)chroman-6-ol
ephanyl
3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2h-1-benzopyran-6-ol
SPECTRUM_001195
SPECTRUM4_001771
10191-41-0
alpha-tochopherol
nsc-82623
dl-tocopherol
.alpha. tocopherol
nsc82623
(.+-.)-med-e
2h-1-benzopyran-6-ol,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, [2r*(4r*,8r*)]-(.+-.)-
BSPBIO_003095
SPECTRUM5_000381
IDI1_000533
2h-1-benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-
(+/-)-alpha-tocopherol, synthetic, >=96% (hplc)
(+/-)-alpha-tocopherol, analytical standard
dl-alpha-tocopherol
D02332
tocopherol (jp17)
NCGC00095254-01
NCGC00095254-02
KBIOGR_002282
KBIO3_002315
KBIO2_004243
KBIO2_001675
KBIO2_006811
KBIOSS_001675
NINDS_000533
SPECTRUM3_001338
SPECTRUM2_000722
SPBIO_000644
SPECTRUM310039
NCGC00095254-03
alpha-tocopherol, >=95.5%
HMS2091C11
7A4513C3-131C-41D4-B6A0-7ED994AC2947
AC-10544
CHEMBL49563 ,
HMS501K15
T0251
HMS1923I03
dl-|a-tocopherol
2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydrochromen-6-ol
NCGC00095254-06
NCGC00095254-05
nsc755839
pharmakon1600-00310039
nsc-755839
AKOS015960364
dl-all-rac-a-tocopherol
CCG-40162
alpha-tocopherol, dl-
5-17-04-00168 (beilstein handbook reference)
unii-7qwa1rio01
hsdb 8261
7qwa1rio01 ,
ec 233-466-0
FT-0624406
FT-0625430
FT-0600386
STL372809
bdbm50436220
S6104
BRD-A82892199-001-01-7
dl-alpha tocopherol [who-dd]
tocopherol,dl-alpha [vandf]
ins no.307c
j24.789h ,
vitamin e dl-alpha
all-rac-alpha-tocopherol [fcc]
dl-alpha tocopherol [mart.]
dl-alpha-tocopherol(307c)
irganox e 210
.alpha.-tocopherol, dl- [ii]
tocopherol, dl-alpha
all-rac-alpha-tocopherol
dl-.alpha.-tocopherol
dl-5,7,8-trimethyltocol
dl-alpha tocopherol
ronotec df 120
dl-.alpha.-tocopherol [mi]
rac-.alpha.-tocopherol
.alpha.-tocopherol, dl-
uvinul 2000ao
ins-307c
all-rac-alpha-tocopheryl acetate impurity c [ep impurity]
e-307c
BBL027614
SCHEMBL22303
SCHEMBL14315133
(.+/-.)-.alpha.-tocopherol
2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-6-chromanol #
F0001-2420
alpha-tocopherol, british pharmacopoeia (bp) reference standard
AB00051898_02
FT-0696605
(+/-)-alpha-tocopherol, tested according to ph.eur.
mfcd00072051
alpha tocopherol, united states pharmacopeia (usp) reference standard
CHEBI:93909
(+/-)-alpha-tocopherol, saj special grade, >=96.0%
SR-05000001813-1
sr-05000001813
SR-05000001813-2
alpha-tocopherol, european pharmacopoeia (ep) reference standard
alpha tocopherol, pharmaceutical secondary standard; certified reference material
dl-alpha-tocopherol (vitamin e)
SBI-0051261.P003
16826-11-2
Q27165663
SY057064
VS-08569
DB14476
2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2h-1-benzopyran-6-ol
dl-alpha-tocopherol (vitamin e) 10 microg/ml in acetonitrile
SY012869
(2r, 4's, 8's)-alpha-tocopherol
D70247
HY-W020044
CS-0031997
c29h50o2 (dl-alpha-tocopherol)
(2s, 4's, 8's)-alpha-tocopherol
all-rac-alpha-tocopherol (vitamin e)
EN300-20897
5,6 trans-calcipotriol
(2r)-alpha-tocopherol (mixture of diastereomers)
(2s, 4'r, 8's)-alpha-tocopherol
alpha-tocopherol-[d6] (vitamin e-[d6])
dl- alpha -tocopherol
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
tocopherolA collective name for a group of closely related lipids that contain a chroman-6-ol nucleus substituted at position 2 by a methyl group and by a saturated hydrocarbon chain consisting of three isoprenoid units. They are designated as alpha-, beta-, gamma-, and delta-tocopherol depending on the number and position of additional methyl substituents on the aromatic ring. Tocopherols occur in vegetable oils and vegetable oil products, almost exclusively with R,R,R configuration. Tocotrienols differ from tocopherols only in having three double bonds in the hydrocarbon chain.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (3)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
USP1 protein, partialHomo sapiens (human)Potency12.67280.031637.5844354.8130AID504865
DNA polymerase kappa isoform 1Homo sapiens (human)Potency11.22020.031622.3146100.0000AID588579
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Presenilin-1Homo sapiens (human)IC50 (µMol)100.00000.00010.23785.6800AID755563; AID755564
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Presenilin-1Homo sapiens (human)EC50 (µMol)100.00000.00010.68575.7000AID755565
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (89)

Processvia Protein(s)Taxonomy
negative regulation of low-density lipoprotein receptor activityPresenilin-1Homo sapiens (human)
endoplasmic reticulum calcium ion homeostasisPresenilin-1Homo sapiens (human)
cell-cell adhesionPresenilin-1Homo sapiens (human)
autophagosome assemblyPresenilin-1Homo sapiens (human)
negative regulation of transcription by RNA polymerase IIPresenilin-1Homo sapiens (human)
blood vessel developmentPresenilin-1Homo sapiens (human)
cell fate specificationPresenilin-1Homo sapiens (human)
somitogenesisPresenilin-1Homo sapiens (human)
neuron migrationPresenilin-1Homo sapiens (human)
positive regulation of receptor recyclingPresenilin-1Homo sapiens (human)
negative regulation of protein phosphorylationPresenilin-1Homo sapiens (human)
positive regulation of protein phosphorylationPresenilin-1Homo sapiens (human)
heart loopingPresenilin-1Homo sapiens (human)
positive regulation of L-glutamate import across plasma membranePresenilin-1Homo sapiens (human)
hematopoietic progenitor cell differentiationPresenilin-1Homo sapiens (human)
astrocyte activation involved in immune responsePresenilin-1Homo sapiens (human)
T cell activation involved in immune responsePresenilin-1Homo sapiens (human)
neural retina developmentPresenilin-1Homo sapiens (human)
protein glycosylationPresenilin-1Homo sapiens (human)
membrane protein ectodomain proteolysisPresenilin-1Homo sapiens (human)
mitochondrial transportPresenilin-1Homo sapiens (human)
DNA damage responsePresenilin-1Homo sapiens (human)
response to oxidative stressPresenilin-1Homo sapiens (human)
Notch receptor processingPresenilin-1Homo sapiens (human)
learning or memoryPresenilin-1Homo sapiens (human)
memoryPresenilin-1Homo sapiens (human)
post-embryonic developmentPresenilin-1Homo sapiens (human)
regulation of gene expressionPresenilin-1Homo sapiens (human)
positive regulation of gene expressionPresenilin-1Homo sapiens (human)
negative regulation of gene expressionPresenilin-1Homo sapiens (human)
regulation of neuron projection developmentPresenilin-1Homo sapiens (human)
protein transportPresenilin-1Homo sapiens (human)
choline transportPresenilin-1Homo sapiens (human)
synaptic vesicle targetingPresenilin-1Homo sapiens (human)
protein processingPresenilin-1Homo sapiens (human)
cerebellum developmentPresenilin-1Homo sapiens (human)
cerebral cortex cell migrationPresenilin-1Homo sapiens (human)
Cajal-Retzius cell differentiationPresenilin-1Homo sapiens (human)
dorsal/ventral neural tube patterningPresenilin-1Homo sapiens (human)
embryonic limb morphogenesisPresenilin-1Homo sapiens (human)
positive regulation of proteasomal ubiquitin-dependent protein catabolic processPresenilin-1Homo sapiens (human)
endoplasmic reticulum calcium ion homeostasisPresenilin-1Homo sapiens (human)
positive regulation of tumor necrosis factor productionPresenilin-1Homo sapiens (human)
amyloid-beta formationPresenilin-1Homo sapiens (human)
intracellular signal transductionPresenilin-1Homo sapiens (human)
locomotionPresenilin-1Homo sapiens (human)
positive regulation of protein import into nucleusPresenilin-1Homo sapiens (human)
regulation of phosphorylationPresenilin-1Homo sapiens (human)
amyloid precursor protein metabolic processPresenilin-1Homo sapiens (human)
amyloid precursor protein catabolic processPresenilin-1Homo sapiens (human)
myeloid dendritic cell differentiationPresenilin-1Homo sapiens (human)
positive regulation of apoptotic processPresenilin-1Homo sapiens (human)
negative regulation of apoptotic processPresenilin-1Homo sapiens (human)
negative regulation of neuron apoptotic processPresenilin-1Homo sapiens (human)
skin morphogenesisPresenilin-1Homo sapiens (human)
positive regulation of glycolytic processPresenilin-1Homo sapiens (human)
positive regulation of DNA-templated transcriptionPresenilin-1Homo sapiens (human)
astrocyte activationPresenilin-1Homo sapiens (human)
regulation of synaptic plasticityPresenilin-1Homo sapiens (human)
thymus developmentPresenilin-1Homo sapiens (human)
neuron developmentPresenilin-1Homo sapiens (human)
skeletal system morphogenesisPresenilin-1Homo sapiens (human)
brain morphogenesisPresenilin-1Homo sapiens (human)
epithelial cell proliferationPresenilin-1Homo sapiens (human)
negative regulation of axonogenesisPresenilin-1Homo sapiens (human)
synapse organizationPresenilin-1Homo sapiens (human)
positive regulation of coagulationPresenilin-1Homo sapiens (human)
T cell receptor signaling pathwayPresenilin-1Homo sapiens (human)
sequestering of calcium ionPresenilin-1Homo sapiens (human)
neuron apoptotic processPresenilin-1Homo sapiens (human)
smooth endoplasmic reticulum calcium ion homeostasisPresenilin-1Homo sapiens (human)
regulation of synaptic transmission, glutamatergicPresenilin-1Homo sapiens (human)
regulation of resting membrane potentialPresenilin-1Homo sapiens (human)
regulation of canonical Wnt signaling pathwayPresenilin-1Homo sapiens (human)
positive regulation of dendritic spine developmentPresenilin-1Homo sapiens (human)
neuron cellular homeostasisPresenilin-1Homo sapiens (human)
calcium ion transmembrane transportPresenilin-1Homo sapiens (human)
apoptotic signaling pathwayPresenilin-1Homo sapiens (human)
regulation of synaptic vesicle cyclePresenilin-1Homo sapiens (human)
L-glutamate import across plasma membranePresenilin-1Homo sapiens (human)
regulation of postsynapse organizationPresenilin-1Homo sapiens (human)
protein catabolic process at postsynapsePresenilin-1Homo sapiens (human)
cellular response to amyloid-betaPresenilin-1Homo sapiens (human)
negative regulation of core promoter bindingPresenilin-1Homo sapiens (human)
positive regulation of amyloid fibril formationPresenilin-1Homo sapiens (human)
neuron projection maintenancePresenilin-1Homo sapiens (human)
negative regulation of ubiquitin-dependent protein catabolic processPresenilin-1Homo sapiens (human)
negative regulation of apoptotic signaling pathwayPresenilin-1Homo sapiens (human)
calcium ion homeostasisPresenilin-1Homo sapiens (human)
Notch signaling pathwayPresenilin-1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (10)

Processvia Protein(s)Taxonomy
endopeptidase activityPresenilin-1Homo sapiens (human)
aspartic-type endopeptidase activityPresenilin-1Homo sapiens (human)
calcium channel activityPresenilin-1Homo sapiens (human)
protein bindingPresenilin-1Homo sapiens (human)
beta-catenin bindingPresenilin-1Homo sapiens (human)
PDZ domain bindingPresenilin-1Homo sapiens (human)
aspartic endopeptidase activity, intramembrane cleavingPresenilin-1Homo sapiens (human)
cadherin bindingPresenilin-1Homo sapiens (human)
ATPase bindingPresenilin-1Homo sapiens (human)
growth factor receptor bindingPresenilin-1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (37)

Processvia Protein(s)Taxonomy
smooth endoplasmic reticulumPresenilin-1Homo sapiens (human)
dendritePresenilin-1Homo sapiens (human)
Golgi membranePresenilin-1Homo sapiens (human)
kinetochorePresenilin-1Homo sapiens (human)
nucleusPresenilin-1Homo sapiens (human)
nuclear outer membranePresenilin-1Homo sapiens (human)
nucleoplasmPresenilin-1Homo sapiens (human)
mitochondrionPresenilin-1Homo sapiens (human)
mitochondrial inner membranePresenilin-1Homo sapiens (human)
endoplasmic reticulumPresenilin-1Homo sapiens (human)
endoplasmic reticulum membranePresenilin-1Homo sapiens (human)
smooth endoplasmic reticulumPresenilin-1Homo sapiens (human)
rough endoplasmic reticulumPresenilin-1Homo sapiens (human)
Golgi apparatusPresenilin-1Homo sapiens (human)
centrosomePresenilin-1Homo sapiens (human)
plasma membranePresenilin-1Homo sapiens (human)
cell cortexPresenilin-1Homo sapiens (human)
synaptic vesiclePresenilin-1Homo sapiens (human)
cell surfacePresenilin-1Homo sapiens (human)
membranePresenilin-1Homo sapiens (human)
aggresomePresenilin-1Homo sapiens (human)
cell junctionPresenilin-1Homo sapiens (human)
growth conePresenilin-1Homo sapiens (human)
neuromuscular junctionPresenilin-1Homo sapiens (human)
early endosome membranePresenilin-1Homo sapiens (human)
nuclear membranePresenilin-1Homo sapiens (human)
ciliary rootletPresenilin-1Homo sapiens (human)
azurophil granule membranePresenilin-1Homo sapiens (human)
sarcolemmaPresenilin-1Homo sapiens (human)
presynaptic membranePresenilin-1Homo sapiens (human)
neuron projectionPresenilin-1Homo sapiens (human)
neuronal cell bodyPresenilin-1Homo sapiens (human)
dendritic shaftPresenilin-1Homo sapiens (human)
membrane raftPresenilin-1Homo sapiens (human)
postsynapsePresenilin-1Homo sapiens (human)
glutamatergic synapsePresenilin-1Homo sapiens (human)
protein-containing complexPresenilin-1Homo sapiens (human)
gamma-secretase complexPresenilin-1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (25)

Assay IDTitleYearJournalArticle
AID1808020Inhibition of porcine heart malate dehydrogenase preincubated for 5 min followed by nicotinamide adenine dinucleotide addition and monitered for 90 sec by spectrophotometric method2021Journal of medicinal chemistry, 12-09, Volume: 64, Issue:23
Colloidal Aggregators in Biochemical SARS-CoV-2 Repurposing Screens.
AID1234238Antioxidant activity assessed as DPPH free radical scavenging activity incubated for 30 mins by ELISA method2015Journal of natural products, Jul-24, Volume: 78, Issue:7
Antioxidant and Anti-Inflammatory Phenolic Glycosides from Clematis tashiroi.
AID977602Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM2013Molecular pharmacology, Jun, Volume: 83, Issue:6
Structure-based identification of OATP1B1/3 inhibitors.
AID1875631Immunomodulatory activity in IL-17A Katushka/IL-10eGFP/Foxp3RFP reporter mouse cell trace violet-labelled CD4+ T cell derived TGF-beta1/IL-6/IL-23-polarized Th17 cells assessed as increase in IL-10 positive cell population at 5 to 20 uM measured after 3 d2022Journal of natural products, 11-25, Volume: 85, Issue:11
Cellular Stress-Induced Metabolites in
AID1197347Antioxidant activity assessed as inhibition of linoleic acid autooxidation2015European journal of medicinal chemistry, Mar-06, Volume: 92Medicinal uses, phytochemistry and pharmacology of family Sterculiaceae: a review.
AID1197346Antioxidant activity in rat liver microsomes assessed as inhibition of NADPH-dependent lipid peroxidation2015European journal of medicinal chemistry, Mar-06, Volume: 92Medicinal uses, phytochemistry and pharmacology of family Sterculiaceae: a review.
AID977599Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM2013Molecular pharmacology, Jun, Volume: 83, Issue:6
Structure-based identification of OATP1B1/3 inhibitors.
AID1808022Inhibition of porcine heart malate dehydrogenase assessed as critical aggregation concentration preincubated for 5 min followed by nicotinamide adenine dinucleotide addition and monitered for 90 sec by spectrophotometric method2021Journal of medicinal chemistry, 12-09, Volume: 64, Issue:23
Colloidal Aggregators in Biochemical SARS-CoV-2 Repurposing Screens.
AID377909Antioxidant activity assessed as DPPH free radical scavenging activity2000Journal of natural products, Oct, Volume: 63, Issue:10
Urinary metabolites of gallic acid in rats and their radical-scavenging effects on 1,1-diphenyl-2-picrylhydrazyl radical.
AID1893994Antioxidant activity assessed as DPPH radical scavenging activity relative to control2021European journal of medicinal chemistry, Jan-15, Volume: 210Xanthenes in Medicinal Chemistry - Synthetic strategies and biological activities.
AID755565Modulation of human gamma-secretase presenilin-1 subunit expressed in CHO cells coexpressing human APP assessed as increase in amyloid beta 38 generation after 24 hrs by ELISA2013Bioorganic & medicinal chemistry letters, Jul-01, Volume: 23, Issue:13
Membrane anchoring γ-secretase modulators with terpene-derived moieties.
AID1875639Immunomodulatory activity in IL-17A Katushka/IL-10eGFP/Foxp3RFP reporter mouse cell trace violet-labelled CD4+ T cell derived TGF-beta1/IL-6/IL-23-polarized Th17 cells assessed as increase in IL-17 positive cell population at 5 to 20 uM measured after 3 d2022Journal of natural products, 11-25, Volume: 85, Issue:11
Cellular Stress-Induced Metabolites in
AID755563Modulation of human gamma-secretase presenilin-1 subunit expressed in CHO cells coexpressing human APP assessed as decrease in amyloid beta 42 generation after 24 hrs by ELISA2013Bioorganic & medicinal chemistry letters, Jul-01, Volume: 23, Issue:13
Membrane anchoring γ-secretase modulators with terpene-derived moieties.
AID195554The IC50 value was measured for inhibition of lipid autoxidation in rat brain homogenate.1995Journal of medicinal chemistry, Jul-21, Volume: 38, Issue:15
Cardioselective ammonium, phosphonium, and sulfonium analogues of alpha-tocopherol and ascorbic acid that inhibit in vitro and ex vivo lipid peroxidation and scavenge superoxide radicals.
AID1808021Inhibition of porcine heart malate dehydrogenase assessed as reduction in enzyme inhibition at 3 times IC50 preincubated for 5 min followed by nicotinamide adenine dinucleotide addition and monitered for 90 sec in presence of 0.01% Triton-X100 by spectrop2021Journal of medicinal chemistry, 12-09, Volume: 64, Issue:23
Colloidal Aggregators in Biochemical SARS-CoV-2 Repurposing Screens.
AID755564Modulation of human gamma-secretase presenilin-1 subunit expressed in CHO cells coexpressing human APP assessed as decrease in amyloid beta 40 generation after 24 hrs by ELISA2013Bioorganic & medicinal chemistry letters, Jul-01, Volume: 23, Issue:13
Membrane anchoring γ-secretase modulators with terpene-derived moieties.
AID312786Inhibition of NADH-induced lipid peroxidation in rat brain microsome2008Journal of medicinal chemistry, Feb-14, Volume: 51, Issue:3
Synthesis and evaluation of 2'-hydroxyethyl trans-apovincaminate derivatives as antioxidant and cognitive enhancer agents.
AID1234237Antioxidant activity assessed as DPPH free radical scavenging activity at 100 ug/ml incubated for 30 mins by ELISA method2015Journal of natural products, Jul-24, Volume: 78, Issue:7
Antioxidant and Anti-Inflammatory Phenolic Glycosides from Clematis tashiroi.
AID1875640Immunomodulatory activity in IL-17A Katushka/IL-10eGFP/Foxp3RFP reporter mouse cell trace violet-labelled CD4+ T cell derived TGF-beta1/IL-6/IL-23-polarized Th17 cells assessed as increase in IL-10/IL-17 positive cell population at 5 to 20 uM measured aft2022Journal of natural products, 11-25, Volume: 85, Issue:11
Cellular Stress-Induced Metabolites in
AID312787Inhibition of Fe2+-induced lipid peroxidation in rat brain homogenate2008Journal of medicinal chemistry, Feb-14, Volume: 51, Issue:3
Synthesis and evaluation of 2'-hydroxyethyl trans-apovincaminate derivatives as antioxidant and cognitive enhancer agents.
AID1197348Antioxidant activity assessed as DPPH radical scavenging activity2015European journal of medicinal chemistry, Mar-06, Volume: 92Medicinal uses, phytochemistry and pharmacology of family Sterculiaceae: a review.
AID504749qHTS profiling for inhibitors of Plasmodium falciparum proliferation2011Science (New York, N.Y.), Aug-05, Volume: 333, Issue:6043
Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets.
AID588519A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities2011Antiviral research, Sep, Volume: 91, Issue:3
High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
AID540299A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis2010Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
AID1159607Screen for inhibitors of RMI FANCM (MM2) intereaction2016Journal of biomolecular screening, Jul, Volume: 21, Issue:6
A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (33)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's8 (24.24)18.2507
2000's7 (21.21)29.6817
2010's14 (42.42)24.3611
2020's4 (12.12)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.18

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.18 (24.57)
Research Supply Index3.53 (2.92)
Research Growth Index4.71 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.18)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews3 (9.09%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other30 (90.91%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]