Page last updated: 2024-08-05 12:16:22
anthracycline antibiotic
An organic compound that has a tetrahydronaphthacenedione ring structure attached by a glycosidic linkage to the amino sugar daunosamine and which exhibits antibiotic activity.
ChEBI ID: 49322
Members (6)
| Member | Definition | Role |
|---|---|---|
| adriamycinol | A member of the class of tetracenequinones that is the major metabolite of the anthracycline doxorubicin, a chemotherapeutic agent effective against a broad range of malignant neoplasms. It is thought to exhibit cardiotoxic properties. | doxorubicinol |
| amrubicin | A synthetic anthracycline antibiotic with molecular formula C25H25NO9. A specific inhibitor of topoisomerase II, it is used (particularly as the hydrochloride salt) in the treatment of cancer, especially lung cancer, where it is a prodrug for the active metabolite, ambrucinol. | amrubicin |
| carubicin | A toxic anthracycline antibiotic that is produced by Actinomadura carminata and also has potent antineoplastic activity. | carminomycin |
| epirubicin | An anthracycline that is the 4'-epi-isomer of doxorubicin. | 4'-epidoxorubicin |
| idarubicin | idarubicin | |
| methoxy-morpholinyl-doxorubicin | nemorubicin |
Research
Studies (7,033)
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 543 (7.72) | 18.7374 |
| 1990's | 1,853 (26.35) | 18.2507 |
| 2000's | 2,194 (31.20) | 29.6817 |
| 2010's | 2,035 (28.94) | 24.3611 |
| 2020's | 408 (5.80) | 2.80 |
Study Types
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 2,385 (30.95%) | 5.53% |
| Reviews | 451 (5.85%) | 6.00% |
| Case Studies | 865 (11.23%) | 4.05% |
| Observational | 31 (0.40%) | 0.25% |
| Other | 3,974 (51.57%) | 84.16% |