Any EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of elongation factor 2 kinase (EC 2.7.11.20).
ChEBI ID: 131734
| Member | Definition | Class |
|---|---|---|
| cefatrizine | A cephalosporin compound having (1H-1,2,3-triazol-4-ylsulfanyl)methyl and [(2R)-2-amino-2-(4-hydroxyphenyl)]acetamido side-groups. An antibacterial drug first prepared in the 1970s, it has more recently been found to be an inhibitor of eukaryotic elongation factor-2 kinase (eEF2K), which is known to regulate apoptosis, autophagy and ER stress in many types of human cancers. | cefatrizine |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 40 (57.14) | 18.7374 |
| 1990's | 13 (18.57) | 18.2507 |
| 2000's | 6 (8.57) | 29.6817 |
| 2010's | 8 (11.43) | 24.3611 |
| 2020's | 3 (4.29) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 11 (14.86%) | 5.53% |
| Reviews | 3 (4.05%) | 6.00% |
| Case Studies | 2 (2.70%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 58 (78.38%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 21.3138 | 1 | 1 |
| GLS protein | Homo sapiens (human) | Potency | 6.3096 | 1 | 1 |
| hypothetical protein, conserved | Trypanosoma brucei | Potency | 31.6228 | 1 | 1 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 25.5748 | 1 | 1 |