Pseudomyxoma Peritonei

A peritoneal adenocarcinoma characterized by build-up of MUCUS in the PERITONEAL CAVITY. Mucus secreting cells may attach to the peritoneal lining and continue to secrete mucus. The majority of cases represent tumor spread from a primary low-grade mucinous neoplasm of the APPENDIX (NCI Thesaurus).

Synonym
Pseudomyxoma Peritonei

Excerpt	Reference
"Two cases of pseudomyxoma peritonei are presented."	( Beller, FK; Nienhaus, H; Zimmerman, RE, 1986)
"Pseudomyxoma peritonei is an unusual malignancy arising from the goblet cells of the large bowel or appendix."	( Kern, K; Lack, E; Sugarbaker, PH, 1987)
"Pseudomyxoma peritonei is a rare disease caused by a perforated adenoma of the appendix."	( Sugarbaker, PH; Zoetmulder, FA, 1996)
"Pseudomyxoma peritonei is a condition characterized by the production of large amounts of mucopolysaccharide by a neoplastic epithelium."	( Horowitz, IR; Roy, WJ; Thomas, BL, 1997)
"Pseudomyxoma peritonei is a rare disease in which the abdominal cavity fills with thick mucoid material secondary to either benign or malignant conditions."	( Raj, J; Raj, PK; ReMine, SG; Urban, LM, 1999)
"Pseudomyxoma peritonei is a rare disease."	( Bossard, N; Brigand, C; Causeret, S; Faheez, M; Gilly, F; Glehen, O; Loungnarath, R; Sayag-Beaujard, AC, 2005)
"Pseudomyxoma peritonei is a condition characterized by the production of a large amount of mucopolysaccharide by a neoplastic epithelium."	( Aso, C; Goto, F; Mieda, R; Nishikawa, K; Saito, S, 2007)
"Pseudomyxoma peritonei is an understudied cancer in which an appendiceal neoplasm invades the peritoneum and forms tumor foci on abdominal organs."	( Dubois, A; Francis, J; Jia, Y; Liu, H; McAvoy, TJ; Merrell, DS; Nieroda, C; Sardi, A; Semino-Mora, C; Studeman, K; Testerman, TL; Whitmire, JM, 2013)
"Pseudomyxoma peritonei is a diffuse peritoneal malignancy that generally originates form a perforated appendiceal tumor."	( Cecil, TD; Chandrakumaran, K; Dayal, S; Mohamed, F; Moran, BJ; Riss, S; Taflampas, P, 2013)
"Pseudomyxoma peritonei is a very rare condition, and even rarer in patients with history of cancer."	( Hong, JU; Jung, TS; Lee, HJ; Lee, JY; Min, IS; Park, SH; Seock, CH, 2016)
"Pseudomyxoma peritonei is a disease that results from a perforated mucinous neoplasm of the appendix so that mucinous ascites and mucin-producing tumor cells are widely disseminated in a characteristic pattern throughout the abdomen and pelvis."	( Sugarbaker, PH, 2017)
"Pseudomyxoma peritonei is rare, almost always of appendiceal origin, and presents in various ways relevant to abdominal surgeons."	( Cecil, TD; Chandrakumaran, K; Dayal, S; Mohamed, F; Moran, BJ; Shariff, US, 2020)
"Pseudomyxoma peritonei is a rare disease with a reported prevalence of about 1-3 per million people annually."	( Gohda, Y; Hayama, N; Hirano, S; Igari, T; Miyazaki, H; Shimizu, S; Yano, H, 2021)

Excerpt	Reference
"The modern treatment of pseudomyxoma peritonei is cytoreductive surgery plus intraperitoneal chemotherapy resulting in a survival of up to 70 percent after 20 years."	( Hansen, F; Iversen, LH; Jess, P; Laurberg, S; Nielsen, MB; Rasmussen, PC, 2008)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	7 (3.91)	23.3326
1990's	32 (17.88)	12.5806
2000's	51 (28.49)	18.1394
2010's	71 (39.66)	28.8240
2020's	18 (10.06)	9.53

Drug	Relationship Strength	Studies	Trials
naphthalene	low	1	0
thymine	low	1	0
amifostine anhydrous	low	1	0
celecoxib	low	1	0
pentetic acid	low	1	0
fluorouracil	medium	49	3
furosemide	low	1	0
guaifenesin	low	13	0
oxonic acid	low	1	0
tegafur	low	1	0
thiotepa	low	1	0
mitomycin	medium	72	4
floxuridine	low	1	0
phenylephrine	low	2	0
mannitol	low	1	0
trifluridine	low	1	0
meglumine	low	1	0
diphenylamine	low	1	0
deoxycytidine	medium	6	1
fucose	low	1	0
sulfur hexafluoride	low	1	0
doxifluridine	low	1	0
mitomycin a	low	1	0
gadolinium	low	2	0
camptothecin	low	6	0
barium sulfate	low	3	0
sizofiran	low	1	0
paclitaxel	low	4	0
etoposide	low	2	0
gemcitabine	low	2	0
irinotecan	low	5	0
fluorodeoxyglucose f18	medium	5	1
fibrinogen	medium	1	1
methotrexate	low	1	0
docetaxel anhydrous	low	1	0
carboplatin	low	3	0
n-acetylneuraminic acid	low	1	0
fibrin	low	1	0
sodium bicarbonate	low	2	0
bromochloroacetic acid	low	10	0
barium	low	1	0
gadolinium dtpa	low	1	0
cgp 48664	medium	1	1
n-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide	low	1	0
glucagon	low	1	0
cellulose	low	1	0
interleukin-8	low	1	0
methylcellulose	low	1	0
ascorbic acid	low	1	0
s 1 (combination)	low	1	0
transforming growth factor beta	low	1	0
grincamycin	low	1	0
hyaluronoglucosaminidase	low	1	0
technetium tc 99m medronate	low	1	0
levoleucovorin	medium	15	1
guanosine diphosphate	low	1	0
alcian blue	low	1	0
leptin	low	1	0

Protein Targets (615)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, JmjC domain-containing histone demethylation protein 3A	2	0	0	2
Chain A, 2-oxoglutarate Oxygenase	6	0	0	6
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
acetylcholinesterase	6	0	0	6
dopamine D1 receptor	3	0	0	3
15-lipoxygenase, partial	5	0	0	5
pregnane X receptor	4	0	0	4
phosphopantetheinyl transferase	6	0	0	6
RAR-related orphan receptor gamma	15	0	0	15
USP1 protein, partial	6	0	0	6
NFKB1 protein, partial	3	0	0	3
Microtubule-associated protein tau	6	0	0	6
Thrombopoietin	3	0	0	3
AR protein	19	0	0	19
regulator of G-protein signaling 4	6	0	0	6
glucocorticoid receptor [Homo sapiens]	12	0	0	12
retinoic acid nuclear receptor alpha variant 1	13	0	0	13
retinoid X nuclear receptor alpha	12	0	0	12
farnesoid X nuclear receptor	13	0	0	13
estrogen nuclear receptor alpha	20	0	0	20
vitamin D (1,25- dihydroxyvitamin D3) receptor	10	0	0	10
arylsulfatase A	4	0	0	4
euchromatic histone-lysine N-methyltransferase 2	12	0	0	12
Bloom syndrome protein isoform 1	5	0	0	5
D(1A) dopamine receptor	2	0	0	2
thyroid hormone receptor beta isoform a	2	0	0	2
thyroid hormone receptor beta isoform 2	17	0	0	17
heat shock protein beta-1	6	0	0	6
flap endonuclease 1	5	0	0	5
geminin	20	0	0	20
peripheral myelin protein 22	8	0	0	8
survival motor neuron protein isoform d	8	0	0	8
muscarinic acetylcholine receptor M1	3	0	0	3
Histone deacetylase 3	0	3	0	3
Solute carrier family 22 member 6	0	2	0	2
Histone deacetylase 4	0	3	0	3
Guanine nucleotide-binding protein G	1	0	0	1
Histone deacetylase 1	0	3	0	3
Histone deacetylase 7	0	3	0	3
Histone deacetylase 2	0	3	0	3
Polyamine deacetylase HDAC10	0	3	0	3
Histone deacetylase 11	0	3	0	3
Ataxin-2	8	0	0	8
Histone deacetylase 8	0	3	0	3
Histone deacetylase 6	0	3	0	3
Histone deacetylase 9	0	3	0	3
Histone deacetylase 5	0	3	0	3
ATP-dependent phosphofructokinase	6	0	0	6
Cellular tumor antigen p53	16	0	0	16
D(3) dopamine receptor	0	2	0	2
Spike glycoprotein	11	0	1	12
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	7	0	0	7
Chain A, Beta-lactamase	4	0	0	4
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
apical membrane antigen 1, AMA1	2	0	0	2
Beta-lactamase	0	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
DNA polymerase eta isoform 1	2	0	0	2
DNA polymerase iota isoform a (long)	7	0	0	7
urokinase-type plasminogen activator precursor	6	0	0	6
plasminogen precursor	6	0	0	6
urokinase plasminogen activator surface receptor precursor	6	0	0	6
DNA polymerase kappa isoform 1	3	0	0	3
ATP-binding cassette sub-family C member 3	0	12	0	12
Multidrug resistance-associated protein 4	0	12	0	13
Bile salt export pump	0	3	0	3
Bile salt export pump	0	14	0	14
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Cytochrome P450 2C9	0	5	0	5
Beta-lactamase	0	0	0	1
Kappa-type opioid receptor	0	0	0	1
Solute carrier family 15 member 1	0	2	0	2
Solute carrier family 15 member 1	0	1	0	1
Cytochrome P450 2J2	0	3	0	3
B2 metallo-beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Canalicular multispecific organic anion transporter 1	0	13	0	14
Chain A, Hyaluronidase, phage associated	0	1	0	1
GLI family zinc finger 3	14	0	0	14
thioredoxin glutathione reductase	2	0	0	2
cytochrome P450 family 3 subfamily A polypeptide 4	11	0	0	11
estrogen-related nuclear receptor alpha	17	0	0	17
IDH1	7	0	0	7
chromobox protein homolog 1	9	0	0	9
nuclear factor erythroid 2-related factor 2 isoform 2	9	0	0	9
nuclear factor erythroid 2-related factor 2 isoform 1	16	0	0	16
lethal(3)malignant brain tumor-like protein 1 isoform I	2	0	0	2
lethal factor (plasmid)	2	0	0	2
lamin isoform A-delta10	14	0	0	14
Polyphenol oxidase 2	0	1	0	1
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	1	0	1
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	1	0	1
Alpha-2B adrenergic receptor	0	3	1	4
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
aldehyde dehydrogenase 1 family, member A1	7	0	0	7
nuclear receptor subfamily 1, group I, member 3	13	0	0	13
thyroid stimulating hormone receptor	5	0	0	5
Nuclear receptor ROR-gamma	2	0	0	2
Chain A, HADH2 protein	4	0	0	4
Chain B, HADH2 protein	4	0	0	4
Chain A, Ferritin light chain	2	0	0	2
Chain A, Cruzipain	2	0	0	2
DNA topoisomerase	0	1	0	1
thioredoxin reductase	10	0	0	10
ATAD5 protein, partial	5	0	0	5
Fumarate hydratase	4	0	0	4
PPM1D protein	4	0	0	4
TDP1 protein	16	0	0	16
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	3	0	0	3
thyroid stimulating hormone receptor	6	0	0	6
EWS/FLI fusion protein	10	0	0	10
polyprotein	4	0	0	4
67.9K protein	12	0	0	12
glucocerebrosidase	2	0	0	2
putative alpha-glucosidase	1	0	0	1
alpha-galactosidase	3	0	0	3
lysosomal alpha-glucosidase preproprotein	2	0	0	2
peripheral myelin protein 22 isoform 1	5	0	0	5
hemoglobin subunit beta	3	0	0	3
cellular tumor antigen p53 isoform a	2	0	0	2
cytochrome P450 2C19 precursor	3	0	0	3
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	4	0	0	4
huntingtin isoform 2	2	0	0	2
ras-related protein Rab-9A	3	0	0	3
eukaryotic translation initiation factor 2-alpha kinase 3 isoform 1 precursor	0	0	1	1
serine/threonine-protein kinase mTOR isoform 1	2	0	0	2
nuclear receptor ROR-gamma isoform 1	3	0	0	3
cytochrome P450 3A4 isoform 1	4	0	0	4
M-phase phosphoprotein 8	5	0	0	5
muscleblind-like protein 1 isoform 1	3	0	0	3
histone acetyltransferase KAT2A isoform 1	4	0	0	4
relaxin receptor 1 isoform 1	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	4	1	0	5
Telomerase reverse transcriptase	0	1	0	1
Serine/threonine-protein kinase Chk1	0	0	1	1
Type-2 restriction enzyme ScaI	0	1	0	1
Deoxyribonuclease-2-alpha	0	1	0	1
Tyrosyl-DNA phosphodiesterase 2	0	1	0	1
Deoxyribonuclease-1	0	1	0	1
Type-2 restriction enzyme PstI	0	1	0	1
Type-2 restriction enzyme EcoRI	0	1	0	1
Prothrombin	0	0	0	2
DNA ligase	0	1	0	1
Interferon beta	7	0	0	7
Integrin beta-3	2	1	0	3
Integrin alpha-IIb	2	0	0	2
Heterogeneous nuclear ribonucleoprotein A1	0	0	1	1
DNA topoisomerase 1	0	2	1	9
DNA topoisomerase 2-alpha	0	2	1	8
Gamma-aminobutyric acid receptor subunit beta-1	4	1	0	5
Gamma-aminobutyric acid receptor subunit delta	4	1	0	5
Gamma-aminobutyric acid receptor subunit gamma-2	4	1	0	5
Gamma-aminobutyric acid receptor subunit alpha-5	4	1	0	5
Gamma-aminobutyric acid receptor subunit alpha-3	4	1	0	5
Gamma-aminobutyric acid receptor subunit gamma-1	4	1	0	5
Gamma-aminobutyric acid receptor subunit alpha-2	4	1	0	5
Type-2 restriction enzyme BamHI	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	4	1	0	5
Gamma-aminobutyric acid receptor subunit gamma-3	4	1	0	5
Gamma-aminobutyric acid receptor subunit alpha-6	4	1	0	5
Somatostatin receptor type 1	0	1	0	1
Somatostatin receptor type 2	0	1	0	1
Somatostatin receptor type 4	0	1	0	1
Somatostatin receptor type 3	0	1	0	1
Somatostatin receptor type 5	0	1	0	1
5-hydroxytryptamine receptor 2B	0	2	0	2
Type-2 restriction enzyme HindIII	0	1	0	1
D(1A) dopamine receptor	1	0	0	1
Ribonuclease pancreatic	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	4	2	0	6
Gamma-aminobutyric acid receptor subunit beta-3	4	1	0	5
Gamma-aminobutyric acid receptor subunit beta-2	4	1	0	5
Inositol monophosphatase 1	2	0	0	2
DNA topoisomerase 2-beta	0	1	1	9
DNA topoisomerase 1	0	1	0	2
DNA topoisomerase 1	0	1	0	1
Integrase	0	2	0	2
GABA theta subunit	4	1	0	5
DNA topoisomerase type IB small subunit	0	0	1	1
Gamma-aminobutyric acid receptor subunit epsilon	4	1	0	5
Tyrosyl-DNA phosphodiesterase 1	0	1	0	1
Liver carboxylesterase 1	0	0	0	2
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	5	0	0	5
Chain A, Putative fructose-1,6-bisphosphate aldolase	3	0	0	3
estrogen receptor 2 (ER beta)	11	0	0	11
G	4	0	0	4
cytochrome P450 2D6	5	0	0	5
vitamin D3 receptor isoform VDRA	4	0	0	4
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
HLA class I histocompatibility antigen, B alpha chain	4	0	0	4
Inositol hexakisphosphate kinase 1	4	0	0	4
cytochrome P450 2C9, partial	4	0	0	4
Chain A, Carbonic anhydrase II	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	2	0	2
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
glp-1 receptor, partial	5	0	0	5
hypoxia-inducible factor 1 alpha subunit	6	0	0	6
SMAD family member 2	4	0	0	4
SMAD family member 3	4	0	0	4
Smad3	1	0	0	1
caspase 7, apoptosis-related cysteine protease	4	0	0	4
progesterone receptor	8	0	0	8
pregnane X nuclear receptor	10	0	0	10
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
peroxisome proliferator-activated receptor delta	7	0	0	7
peroxisome proliferator activated receptor gamma	10	0	0	10
Carbonic anhydrase	0	1	0	1
Rac1 protein	0	0	1	1
caspase-3	4	0	0	4
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	7	0	0	7
activating transcription factor 6	4	0	0	4
thyrotropin-releasing hormone receptor	2	0	0	2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	4	0	0	4
v-jun sarcoma virus 17 oncogene homolog (avian)	5	0	0	5
Histone H2A.x	8	0	0	8
Caspase-7	1	0	0	1
interferon gamma precursor	0	0	0	3
prostaglandin E2 receptor EP2 subtype	0	0	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	4	0	0	4
caspase-3	1	0	0	1
Prostaglandin E synthase	0	1	0	1
3-phosphoinositide-dependent protein kinase 1	0	1	0	1
Carbonic anhydrase 12	0	2	0	3
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Cytochrome c oxidase subunit 1	0	1	0	1
Cytochrome c oxidase subunit 2	0	1	0	1
Catechol O-methyltransferase	0	1	0	1
Voltage-dependent calcium channel gamma-2 subunit	6	0	0	6
Cytochrome c oxidase subunit 2	0	1	0	1
Carbonic anhydrase 1	0	4	0	5
Carbonic anhydrase 2	0	4	1	6
Prostaglandin G/H synthase 1	0	1	0	1
Carbonic anhydrase 3	0	2	0	2
Procathepsin L	0	1	1	2
Aldo-keto reductase family 1 member B1	0	2	0	2
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	1	1	0	2
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Quinolone resistance protein NorA	0	1	0	1
Adenosine receptor A3	0	2	0	2
Cytochrome P450 2D6	0	2	0	2
Neuronal acetylcholine receptor subunit beta-2	1	1	0	2
Beta-3 adrenergic receptor	0	2	1	3
Alpha-1B adrenergic receptor	0	3	0	3
Calpain-2 catalytic subunit	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Glutamate receptor 2	6	0	0	6
D(1A) dopamine receptor	0	2	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Carbonic anhydrase 4	0	3	0	4
Prostaglandin G/H synthase 1	0	1	0	2
Carbonic anhydrase 6	0	2	0	3
Sodium-dependent noradrenaline transporter	0	2	0	2
Adenosine receptor A1	0	1	0	1
Cruzipain	0	1	0	1
Sodium/hydrogen exchanger 1	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	2	0	2
Sodium-dependent serotonin transporter	0	2	0	2
Sodium-dependent serotonin transporter	0	0	1	1
Delta-type opioid receptor	0	1	0	1
Delta-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	3	0	3
Bifunctional epoxide hydrolase 2	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	3	0	4
Prostaglandin G/H synthase 2	0	2	1	4
Prostaglandin G/H synthase 2	0	1	0	1
Carbonic anhydrase	0	2	0	2
Alpha-1A adrenergic receptor	0	3	0	3
Carbonic anhydrase 7	0	2	0	3
Urotensin-2 receptor	0	1	0	1
Carbonic anhydrase	0	1	0	1
Ras-related protein Rab-2A	0	0	1	1
D(2) dopamine receptor	0	1	0	1
Prostaglandin G/H synthase 2	0	2	0	2
Carbonic anhydrase	0	1	0	1
Mu-type opioid receptor	0	2	0	2
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Sodium-dependent dopamine transporter	0	2	0	2
Prostaglandin G/H synthase 2	0	1	0	1
Mitogen-activated protein kinase 14	0	1	0	1
Carbonic anhydrase 9	0	4	0	5
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Sigma intracellular receptor 2	0	1	0	1
Delta carbonic anhydrase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Carbonic anhydrase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
Cyclooxygenase-2	0	1	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
Carbonic anhydrase 4	0	2	0	2
ATPase family AAA domain-containing protein 5	6	0	0	6
Carbonic anhydrase 15	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Carbonic anhydrase 14	0	2	0	3
Carbonic anhydrase 5B, mitochondrial	0	3	0	4
importin subunit beta-1 isoform 1	3	0	0	3
mitogen-activated protein kinase 1	1	0	0	1
snurportin-1	3	0	0	3
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
streptokinase A precursor	0	0	2	2
ATP-dependent translocase ABCB1	0	5	0	8
Cytochrome P450 3A4	0	3	0	3
Potassium voltage-gated channel subfamily H member 2	0	1	0	1
Solute carrier organic anion transporter family member 1B3	0	5	0	6
Solute carrier organic anion transporter family member 1B1	0	3	0	3
Thymidine kinase 2	0	1	0	1
Deoxycytidine kinase	0	0	0	2
Probable deoxycytidylate deaminase	0	0	0	1
Cytidine deaminase	0	0	0	2
AAA family ATPase	0	0	0	2
Reverse transcriptase/RNaseH	0	0	1	1
Luciferase	5	0	0	5
ClpP	2	0	0	2
Glycoprotein hormones alpha chain	1	0	0	1
UDP-glucuronosyltransferase 1A4	0	1	0	2
nuclear receptor subfamily 1, group I, member 2	4	0	0	4
Serum paraoxonase/arylesterase 1	0	4	0	4
Kinesin-like protein KIF11	0	1	0	1
Nucleotide-binding oligomerization domain-containing protein 2	0	2	0	2
Thymidylate kinase	0	2	0	2
Uridine phosphorylase 1	0	0	0	1
LMP1 [Human herpesvirus 4]	0	0	0	2
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	2	0	2
transactivating tegument protein VP16 [Human herpesvirus 1]	0	2	0	2
nuclear receptor coactivator 3 isoform a	0	2	0	2
Regulatory protein E2	0	0	1	1
ATP-dependent translocase ABCB1	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
DNA topoisomerase 2	0	0	0	1
ATP-dependent translocase ABCB1	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	1	0	2
Glutamate receptor ionotropic, NMDA 1	0	0	0	1
Caspase-3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	0	0	1
Glutamate receptor ionotropic, NMDA 2B	0	0	0	1
Glutamate receptor ionotropic, NMDA 2C	0	0	0	1
DNA topoisomerase 2-alpha	0	0	0	1
Glutamate receptor ionotropic, NMDA 2D	0	0	0	1
Tubulin beta-2B chain	0	1	1	4
Similar to alpha-tubulin isoform 1	0	1	1	4
Similar to alpha-tubulin isoform 1	0	1	0	3
Glutamate receptor ionotropic, NMDA 3B	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	0	0	1
Sodium/nucleoside cotransporter 2	0	1	0	1
Thymidylate synthase	0	4	0	5
Thymidine phosphorylase	0	0	0	2
Thymidine kinase	0	0	0	1
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
interleukin 8	1	0	0	1
endonuclease IV	2	0	0	2
Skn7p	0	0	0	1
nonstructural protein 1	2	0	0	2
Vpr	1	0	0	1
Solute carrier family 22 member 8	0	0	0	1
Epidermal growth factor receptor	0	2	0	2
Amyloid-beta precursor protein	2	0	0	2
Aromatase	0	1	0	1
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
Fucose-binding lectin PA-IIL	0	1	0	1
CD209 antigen	0	2	0	2
aryl hydrocarbon receptor	3	0	0	3
Albumin	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	2	0	2
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Adenosine receptor A1	0	1	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
6-phosphogluconate dehydrogenase, decarboxylating	0	2	0	2
Holo-[acyl-carrier-protein] synthase	0	1	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
Multidrug and toxin extrusion protein 1	0	2	0	2
Carbonic anhydrase 13	0	1	0	2
G-protein coupled receptor 35	0	1	1	2
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	2	0	3
Chain A, DEOXYNUCLEOSIDE KINASE	0	1	0	1
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	1	1	2
Transmembrane protease serine 2	0	0	1	1
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	1	1	2
Equilibrative nucleoside transporter 1	0	1	0	1
Angiotensin-converting enzyme 2	0	0	1	1
Rap guanine nucleotide exchange factor 3	1	0	0	1
Chain A, ELONGATION FACTOR TU (EF-TU)	0	0	1	1
Chain A, Elongation Factor G	0	0	1	1
Chain A, ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 3	0	0	1	1
Chain A, Eukaryotic peptide chain release factor GTP-binding subunit	0	0	1	1
Chain A, ras-related C3 botulinum toxin substrate 1 isoform Rac1b	0	0	1	1
Chain A, ras-related C3 botulinum toxin substrate 1 isoform Rac1b	0	0	1	1
Chain A, interferon-inducible GTPase	0	0	1	1
Chain A, interferon-inducible GTPase	0	0	1	1
Chain A, Elongation factor 2	0	0	1	1
Chain A, Guanine nucleotide-binding protein G(i), alpha-1 subunit	0	0	1	1
72 kDa type IV collagenase	0	1	0	1
Matrilysin	0	1	0	1
2-dehydropantoate 2-reductase	0	0	1	1
Ras-related protein Rab-7a	0	0	1	1
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6	0	1	0	1
Disintegrin and metalloproteinase domain-containing protein 17	0	1	0	1
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT5	0	1	0	1
Alpha-(1,3)-fucosyltransferase 7	0	1	0	1
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1	0	1	0	1
P2Y purinoceptor 6	0	0	1	1
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9	0	2	0	2
Chain A, Acetylcholinesterase	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
Solute carrier family 22 member 1	0	1	0	1
Solute carrier family 22 member 3	0	1	0	1
Interstitial collagenase	0	1	0	1
Acetylcholinesterase	0	1	0	1
Muscarinic acetylcholine receptor M4	0	2	0	2
Alpha-2C adrenergic receptor	0	3	1	4
Acetylcholinesterase	0	2	0	2
Multidrug and toxin extrusion protein 2	0	1	0	1
GLS protein	1	0	0	1
Parkin	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
cytochrome P450 2D6 isoform 1	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	2	0	0	2
cytochrome P450 2C9 precursor	1	0	0	1
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
phosphoethanolamine/phosphocholine phosphatase isoform 1	0	1	0	1
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
serine/threonine-protein kinase PLK1	2	0	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-1	0	1	0	1
Microtubule-associated protein tau	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-2	0	1	0	1
Cytochrome P450 2C19	0	1	0	1
Alpha-synuclein	1	0	0	1
Histamine H2 receptor	2	0	0	2
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	1	0	0	1
Fatty acid synthase	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-2	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit gamma	0	1	0	1
WD repeat-containing protein 5	0	1	0	1
Histone-lysine N-methyltransferase 2A	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Cytosolic endo-beta-N-acetylglucosaminidase	0	1	0	1
Indoleamine 2,3-dioxygenase 2	0	1	0	1
TAR DNA-binding protein 43	2	0	0	2
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
acid sphingomyelinase	1	0	0	1
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	3	0	0	3
transcriptional regulator ERG isoform 3	1	0	0	1
DNA polymerase beta	1	0	0	1
caspase-1 isoform alpha precursor	1	0	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	1	1	2
Thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	1	0	2
High mobility group protein B1	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Multidrug resistance-associated protein 1	0	0	0	1
Kappa-type opioid receptor	0	1	0	1
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Caspase-7	1	0	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Solute carrier family 22 member 6	0	0	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 8	0	0	0	1
Solute carrier family 22 member 6	0	1	0	1
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Solute carrier family 22 member 11	0	0	0	1
Protein-arginine deiminase type-4	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Sialidase-4	0	1	0	1
Sialidase-1	0	1	0	1
Sialidase-3	0	1	0	1
Sialidase-2	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
Cytochrome P450 1A2	0	1	0	1
Cytochrome P450 2A6	0	1	0	1
Cytochrome P450 2A5	0	1	0	1
Genome polyprotein	0	1	0	1
Tubulin alpha-1A chain	0	0	1	2
Tubulin beta chain	0	0	1	1
Tubulin beta-4A chain	0	1	1	3
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Tyrosine-protein kinase Fyn	0	1	0	1
Integrin alpha-V	0	1	0	1
Tubulin beta chain	0	1	1	3
60 kDa chaperonin	0	1	0	1
Tubulin alpha-3C chain	0	1	1	3
Botulinum neurotoxin type A	0	1	0	1
Apoptosis regulator Bcl-2	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	1	0	1
Fibroblast growth factor receptor 1	0	1	0	1
Proto-oncogene tyrosine-protein kinase Src	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	1	0	1
Substance-K receptor	0	2	0	2
Cholecystokinin receptor type A	0	2	0	2
Melanocortin receptor 5	0	2	0	2
UDP-glucuronosyltransferase 2B10	0	1	0	1
Delta-type opioid receptor	0	2	0	2
10 kDa heat shock protein, mitochondrial	0	1	0	1
Tubulin alpha-1B chain	0	1	1	3
Tubulin alpha-4A chain	0	1	1	3
Tubulin beta-4B chain	0	1	1	3
Bcl-2-like protein 1	0	1	0	1
Tyrosine-protein kinase Mer	0	1	0	1
Tubulin beta-3 chain	0	2	1	4
Tubulin beta-2A chain	0	1	1	3
Thiosulfate sulfurtransferase	0	1	0	1
Beta-tubulin	0	1	0	1
Tubulin beta-8 chain	0	1	1	3
60 kDa chaperonin	0	1	0	1
Tubulin alpha-3E chain	0	1	1	3
Tubulin alpha-1A chain	0	1	1	3
10 kDa chaperonin	0	1	0	1
Tubulin alpha-1C chain	0	1	1	3
Tubulin beta-6 chain	0	1	1	3
Tubulin beta-2B chain	0	1	1	3
Tubulin beta-1 chain	0	1	1	3
GALC protein	2	0	0	2
Alpha-1B adrenergic receptor	0	0	1	1
Beta-2 adrenergic receptor	0	0	1	1
Beta-1 adrenergic receptor	0	0	1	1
Alpha-2A adrenergic receptor	0	1	1	2
POU domain, class 2, transcription factor 1	0	0	0	1
Beta-1 adrenergic receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	1	1	2
Alpha-1B adrenergic receptor	0	1	0	1
Alpha-2B adrenergic receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
Alpha-2B adrenergic receptor	0	0	0	1
Alpha-1A adrenergic receptor	0	1	1	2
Alpha-1B adrenergic receptor	0	1	1	2
Alpha-2C adrenergic receptor	0	0	0	1
Alpha-2A adrenergic receptor	0	0	0	1
Carbonic anhydrase	0	1	0	1
Cytochrome P450 2B1	0	1	0	1
Cytochrome P450 2B6	0	1	0	1
Thymidine phosphorylase	0	1	0	1
Thymidine kinase	0	1	0	1
exodeoxyribonuclease V subunit RecD	0	1	0	1
exodeoxyribonuclease V subunit RecB	0	1	0	1
exodeoxyribonuclease V subunit RecC	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Treatment

Research

Studies (179)

Protein Targets (615)

Pseudomyxoma Peritonei

Synonyms(1)

Research Excerpts

Overview

Treatment

Research

Studies (179)

Drugs Studied (78)

Protein Targets (615)