Compounds > dimethisterone
Page last updated: 2024-09-20

dimethisterone

Description

Dimethisterone: A synthetic progestational hormone without significant estrogenic or androgenic properties. It was formerly used as the progestational component in SEQUENTIAL ORAL CONTRACEPTIVE AGENTS [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID6607
CHEMBL ID2106347
CHEBI ID4606
SCHEMBL ID146840
MeSH IDM0006451

Synonyms (48)

Synonym
6alpha,21-dimethyl-17alpha-ethinyl testosterone
17-alpha-pregn-4-en-20-yn-3-one, 6-alpha,21-dimethyl-17-hydroxy-
secrosteron
dimetisterona [inn-spanish]
androst-4-en-3-one, 17-beta-hydroxy-6-alpha-methyl-17-(1-propynyl)-
androst-4-en-3-one, 17-hydroxy-6-methyl-17-(1-propynyl)-, (6-alpha,17-beta)-
einecs 201-215-4
dimethisteron
17-alpha-ethynyl-6-alpha,21-dimethyltestosterone
dimethisteronum [inn-latin]
6-alpha,21-dimethylethisterone
dimethisterone [progestins]
androst-4-en-3-one, 17-hydroxy-6-methyl-17-(1-propynyl)-, (6alpha,17beta)-
lutogan
dimetisterone [dcit]
p-5048
6-alpha-methyl-17-alpha-propynyltestosterone
17-alpha-ethynyl-17-hydroxy-6-alpha,21-dimethylandrost-4-en-3-one
17-beta-hydroxy-6-alpha-methyl-17-(1-propynyl)androst-4-en-3-one
6-alpha-methyl-17-(1-propynyl)testosterone
6-alpha,21-dimethyl-17-alpha-ethinyltestosterone
(6-alpha,17-beta)-17-hydroxy-6-methyl-17-(1-propynyl)-androst-4-en-3-one
6-alpha,21-dimethyl-17-beta-hydroxy-17-alpha-pregn-4-en-20-yn-3-one
6alpha,21-dimethyl-17alpha-ethinyltestosterone
79-64-1
C07628
dimethisterone anhydrous
dimethisterone
(6s,8r,9s,10r,13s,14s,17s)-17-hydroxy-6,10,13-trimethyl-17-prop-1-ynyl-2,6,7,8,9,11,12,14,15,16-decahydro-1h-cyclopenta[a]phenanthren-3-one
chebi:4606 ,
CHEMBL2106347
dimetisterona
dimethisteronum
unii-oic9m646c5
oic9m646c5 ,
dimetisterone
dimethisterone [inn]
dimethisterone [mi]
dimethisterone [who-dd]
SCHEMBL146840
dtxcid6031623
cas-79-64-1
tox21_113973
dtxsid5057834 ,
NCGC00274271-01
androst-4-en-3-one,17-hydroxy-6-methyl-17-(1-propynyl)-,(6a,17b)-
(6s,8r,9s,10r,13s,14s,17s)-17-hydroxy-6,10,13-trimethyl-17-(prop-1-ynyl)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-3(2h)-one
Q5277305

Roles (1)

RoleDescription
androgenA sex hormone that stimulates or controls the development and maintenance of masculine characteristics in vertebrates by binding to androgen receptors.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
3-hydroxy steroidAny hydroxy steroid carrying a hydroxy group at position 3.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (26)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
RAR-related orphan receptor gammaMus musculus (house mouse)Potency26.60320.006038.004119,952.5996AID1159521; AID1159523
SMAD family member 2Homo sapiens (human)Potency18.99590.173734.304761.8120AID1346924
SMAD family member 3Homo sapiens (human)Potency18.99590.173734.304761.8120AID1346924
GLI family zinc finger 3Homo sapiens (human)Potency9.03200.000714.592883.7951AID1259369; AID1259392
AR proteinHomo sapiens (human)Potency0.16840.000221.22318,912.5098AID1259243; AID1259247; AID1259381
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency26.60320.000657.913322,387.1992AID1259378
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency12.19970.001022.650876.6163AID1224838; AID1224893
progesterone receptorHomo sapiens (human)Potency0.01810.000417.946075.1148AID1346784; AID1347036
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency0.21880.01237.983543.2770AID1645841
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency16.45180.003041.611522,387.1992AID1159552; AID1159555
retinoid X nuclear receptor alphaHomo sapiens (human)Potency23.91450.000817.505159.3239AID1159531
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency28.07650.001530.607315,848.9004AID1224841; AID1224842; AID1224848; AID1224849; AID1259401; AID1259403
farnesoid X nuclear receptorHomo sapiens (human)Potency23.70830.375827.485161.6524AID743217
pregnane X nuclear receptorHomo sapiens (human)Potency23.71010.005428.02631,258.9301AID1346982
GVesicular stomatitis virusPotency17.37680.01238.964839.8107AID1645842
cytochrome P450 2D6Homo sapiens (human)Potency38.90180.00108.379861.1304AID1645840
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency8.41200.023723.228263.5986AID743222
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency17.04240.057821.109761.2679AID1159526; AID1159528
Histone H2A.xCricetulus griseus (Chinese hamster)Potency8.99810.039147.5451146.8240AID1224845; AID1224896
heat shock protein beta-1Homo sapiens (human)Potency37.57510.042027.378961.6448AID743210
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency24.65390.000627.21521,122.0200AID743202; AID743219
Interferon betaHomo sapiens (human)Potency15.31570.00339.158239.8107AID1347407; AID1645842
HLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)Potency17.37680.01238.964839.8107AID1645842
Spike glycoproteinSevere acute respiratory syndrome-related coronavirusPotency19.95260.009610.525035.4813AID1479145
Inositol hexakisphosphate kinase 1Homo sapiens (human)Potency17.37680.01238.964839.8107AID1645842
cytochrome P450 2C9, partialHomo sapiens (human)Potency17.37680.01238.964839.8107AID1645842
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (45)

Processvia Protein(s)Taxonomy
cell surface receptor signaling pathway via JAK-STATInterferon betaHomo sapiens (human)
response to exogenous dsRNAInterferon betaHomo sapiens (human)
B cell activation involved in immune responseInterferon betaHomo sapiens (human)
cell surface receptor signaling pathwayInterferon betaHomo sapiens (human)
cell surface receptor signaling pathway via JAK-STATInterferon betaHomo sapiens (human)
response to virusInterferon betaHomo sapiens (human)
positive regulation of autophagyInterferon betaHomo sapiens (human)
cytokine-mediated signaling pathwayInterferon betaHomo sapiens (human)
natural killer cell activationInterferon betaHomo sapiens (human)
positive regulation of peptidyl-serine phosphorylation of STAT proteinInterferon betaHomo sapiens (human)
cellular response to interferon-betaInterferon betaHomo sapiens (human)
B cell proliferationInterferon betaHomo sapiens (human)
negative regulation of viral genome replicationInterferon betaHomo sapiens (human)
innate immune responseInterferon betaHomo sapiens (human)
positive regulation of innate immune responseInterferon betaHomo sapiens (human)
regulation of MHC class I biosynthetic processInterferon betaHomo sapiens (human)
negative regulation of T cell differentiationInterferon betaHomo sapiens (human)
positive regulation of transcription by RNA polymerase IIInterferon betaHomo sapiens (human)
defense response to virusInterferon betaHomo sapiens (human)
type I interferon-mediated signaling pathwayInterferon betaHomo sapiens (human)
neuron cellular homeostasisInterferon betaHomo sapiens (human)
cellular response to exogenous dsRNAInterferon betaHomo sapiens (human)
cellular response to virusInterferon betaHomo sapiens (human)
negative regulation of Lewy body formationInterferon betaHomo sapiens (human)
negative regulation of T-helper 2 cell cytokine productionInterferon betaHomo sapiens (human)
positive regulation of apoptotic signaling pathwayInterferon betaHomo sapiens (human)
response to exogenous dsRNAInterferon betaHomo sapiens (human)
B cell differentiationInterferon betaHomo sapiens (human)
natural killer cell activation involved in immune responseInterferon betaHomo sapiens (human)
adaptive immune responseInterferon betaHomo sapiens (human)
T cell activation involved in immune responseInterferon betaHomo sapiens (human)
humoral immune responseInterferon betaHomo sapiens (human)
positive regulation of T cell mediated cytotoxicityHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
adaptive immune responseHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independentHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
regulation of T cell anergyHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
defense responseHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
immune responseHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
detection of bacteriumHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
regulation of interleukin-12 productionHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
regulation of interleukin-6 productionHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
protection from natural killer cell mediated cytotoxicityHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
innate immune responseHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
regulation of dendritic cell differentiationHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
antigen processing and presentation of endogenous peptide antigen via MHC class IbHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
inositol phosphate metabolic processInositol hexakisphosphate kinase 1Homo sapiens (human)
phosphatidylinositol phosphate biosynthetic processInositol hexakisphosphate kinase 1Homo sapiens (human)
negative regulation of cold-induced thermogenesisInositol hexakisphosphate kinase 1Homo sapiens (human)
inositol phosphate biosynthetic processInositol hexakisphosphate kinase 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (18)

Processvia Protein(s)Taxonomy
cytokine activityInterferon betaHomo sapiens (human)
cytokine receptor bindingInterferon betaHomo sapiens (human)
type I interferon receptor bindingInterferon betaHomo sapiens (human)
protein bindingInterferon betaHomo sapiens (human)
chloramphenicol O-acetyltransferase activityInterferon betaHomo sapiens (human)
TAP bindingHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
signaling receptor bindingHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
protein bindingHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
peptide antigen bindingHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
TAP bindingHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
protein-folding chaperone bindingHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
inositol-1,3,4,5,6-pentakisphosphate kinase activityInositol hexakisphosphate kinase 1Homo sapiens (human)
inositol hexakisphosphate kinase activityInositol hexakisphosphate kinase 1Homo sapiens (human)
inositol heptakisphosphate kinase activityInositol hexakisphosphate kinase 1Homo sapiens (human)
inositol hexakisphosphate 5-kinase activityInositol hexakisphosphate kinase 1Homo sapiens (human)
protein bindingInositol hexakisphosphate kinase 1Homo sapiens (human)
ATP bindingInositol hexakisphosphate kinase 1Homo sapiens (human)
inositol hexakisphosphate 1-kinase activityInositol hexakisphosphate kinase 1Homo sapiens (human)
inositol hexakisphosphate 3-kinase activityInositol hexakisphosphate kinase 1Homo sapiens (human)
inositol 5-diphosphate pentakisphosphate 5-kinase activityInositol hexakisphosphate kinase 1Homo sapiens (human)
inositol diphosphate tetrakisphosphate kinase activityInositol hexakisphosphate kinase 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (23)

Processvia Protein(s)Taxonomy
extracellular spaceInterferon betaHomo sapiens (human)
extracellular regionInterferon betaHomo sapiens (human)
Golgi membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
endoplasmic reticulumHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
Golgi apparatusHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
plasma membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
cell surfaceHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
ER to Golgi transport vesicle membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
secretory granule membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
phagocytic vesicle membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
early endosome membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
recycling endosome membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
extracellular exosomeHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
lumenal side of endoplasmic reticulum membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
MHC class I protein complexHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
extracellular spaceHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
external side of plasma membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
virion membraneSpike glycoproteinSevere acute respiratory syndrome-related coronavirus
fibrillar centerInositol hexakisphosphate kinase 1Homo sapiens (human)
nucleoplasmInositol hexakisphosphate kinase 1Homo sapiens (human)
cytosolInositol hexakisphosphate kinase 1Homo sapiens (human)
nucleusInositol hexakisphosphate kinase 1Homo sapiens (human)
cytoplasmInositol hexakisphosphate kinase 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (31)

Assay IDTitleYearJournalArticle
AID1347102qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh18 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347083qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347099qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB1643 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347094qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-37 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347105qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for MG 63 (6-TG R) cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347101qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-12 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347425Rhodamine-PBP qHTS Assay for Modulators of WT P53-Induced Phosphatase 1 (WIP1)2019The Journal of biological chemistry, 11-15, Volume: 294, Issue:46
Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens.
AID1296008Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening2020SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1347090qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for DAOY cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347407qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Pharmaceutical Collection2020ACS chemical biology, 07-17, Volume: 15, Issue:7
High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle.
AID1347154Primary screen GU AMC qHTS for Zika virus inhibitors2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1347106qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for control Hh wild type fibroblast cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347104qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for RD cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347103qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for OHS-50 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1508630Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay2021Cell reports, 04-27, Volume: 35, Issue:4
A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
AID1347107qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh30 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347097qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Saos-2 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID1347100qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for LAN-5 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347089qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for TC32 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347091qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SJ-GBM2 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347093qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-MC cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347082qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347086qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347096qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for U-2 OS cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347108qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh41 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347095qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB-EBc1 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347424RapidFire Mass Spectrometry qHTS Assay for Modulators of WT P53-Induced Phosphatase 1 (WIP1)2019The Journal of biological chemistry, 11-15, Volume: 294, Issue:46
Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens.
AID1347092qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for A673 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID1347098qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-SH cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (82)

TimeframeStudies, This Drug (%)All Drugs %
pre-199074 (90.24)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (2.44)24.3611
2020's6 (7.32)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials3 (3.37%)5.53%
Reviews4 (4.49%)6.00%
Case Studies5 (5.62%)4.05%
Observational0 (0.00%)0.25%
Other77 (86.52%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
norethynodrel[no description available]medium180oxo steroid
chlormadinone acetate[no description available]medium252corticosteroid hormone
ethynodiol diacetate[no description available]medium212steroid ester;
terminal acetylenic compound		contraceptive drug;
estrogen receptor modulator;
synthetic oral contraceptive
medroxyprogesterone acetate[no description available]medium4020-oxo steroid;
3-oxo-Delta(4) steroid;
acetate ester;
corticosteroid;
steroid ester		adjuvant;
androgen;
antineoplastic agent;
antioxidant;
female contraceptive drug;
inhibitor;
progestin;
synthetic oral contraceptive
norgestrel[no description available]medium150
norethindrone[no description available]medium34217beta-hydroxy steroid;
3-oxo-Delta(4) steroid;
terminal acetylenic compound;
tertiary alcohol		progestin;
synthetic oral contraceptive
mestranol[no description available]medium31217beta-hydroxy steroid;
aromatic ether;
terminal acetylenic compound		prodrug;
xenoestrogen
megestrol acetate[no description available]medium3020-oxo steroid;
3-oxo-Delta(4) steroid;
acetate ester;
steroid ester		antineoplastic agent;
appetite enhancer;
contraceptive drug;
progestin;
synthetic oral contraceptive
diethylstilbestrol[no description available]medium20olefinic compound;
polyphenol		antifungal agent;
antineoplastic agent;
autophagy inducer;
calcium channel blocker;
carcinogenic agent;
EC 1.1.1.146 (11beta-hydroxysteroid dehydrogenase) inhibitor;
EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor;
endocrine disruptor;
xenoestrogen
ethinyl estradiol[no description available]medium53317-hydroxy steroid;
3-hydroxy steroid;
terminal acetylenic compound		xenoestrogen
megestrol[no description available]medium15017alpha-hydroxy steroid;
20-oxo steroid;
3-oxo-Delta(4) steroid;
tertiary alpha-hydroxy ketone		antineoplastic agent;
appetite enhancer;
contraceptive drug;
progestin;
synthetic oral contraceptive
lynestrenol[no description available]medium50steroid
ethisterone[no description available]medium1017beta-hydroxy steroid;
3-oxo-Delta(4) steroid;
terminal acetylenic compound;
tertiary alcohol		drug metabolite;
progestin
medroxyprogesterone[no description available]medium15017alpha-hydroxy steroid;
20-oxo steroid;
3-oxo-Delta(4) steroid;
tertiary alpha-hydroxy ketone		contraceptive drug;
progestin;
synthetic oral contraceptive
gastrins[no description available]medium10
thromboplastin[no description available]medium10
pyridoxine[no description available]medium10hydroxymethylpyridine;
methylpyridines;
monohydroxypyridine;
vitamin B6		cofactor;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
tryptophan[no description available]medium10erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
proteinogenic amino acid;
tryptophan zwitterion;
tryptophan		antidepressant;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
ascorbic acid[no description available]medium20ascorbic acid;
vitamin C		coenzyme;
cofactor;
flour treatment agent;
food antioxidant;
food colour retention agent;
geroprotector;
plant metabolite;
skin lightening agent
thyroxine[no description available]medium202-halophenol;
iodophenol;
L-phenylalanine derivative;
non-proteinogenic L-alpha-amino acid;
thyroxine zwitterion;
thyroxine		antithyroid drug;
human metabolite;
mouse metabolite;
thyroid hormone
triiodothyronine[no description available]medium102-halophenol;
amino acid zwitterion;
iodophenol;
iodothyronine		human metabolite;
mouse metabolite;
thyroid hormone
nandrolone[no description available]medium2017beta-hydroxy steroid;
3-oxo-Delta(4) steroid;
anabolic androgenic steroid		human metabolite
phenyl acetate[no description available]medium20benzenes;
phenyl acetates
acid phosphatase[no description available]medium10
pregnanediol[no description available]medium10
enclomiphene[no description available]medium10
dydrogesterone[no description available]medium1020-oxo steroid;
3-oxo-Delta(4) steroid		progestin
testosterone[no description available]medium003-hydroxy steroidandrogen
oxandrolone[no description available]low0017beta-hydroxy steroid;
3-oxo steroid;
anabolic androgenic steroid;
oxa-steroid		anabolic agent;
androgen
androsterone[no description available]low0017-oxo steroid;
3alpha-hydroxy steroid;
androstanoid;
C19-steroid		androgen;
anticonvulsant;
human blood serum metabolite;
human metabolite;
human urinary metabolite;
mouse metabolite;
pheromone
dehydroepiandrosterone[no description available]low0017-oxo steroid;
3beta-hydroxy-Delta(5)-steroid;
androstanoid		androgen;
human metabolite;
mouse metabolite
methyltestosterone[no description available]low0017beta-hydroxy steroid;
3-oxo-Delta(4) steroid;
enone		anabolic agent;
androgen;
antineoplastic agent
androstenedione[no description available]low0017-oxo steroid;
3-oxo-Delta(4) steroid;
androstanoid		androgen;
Daphnia magna metabolite;
human metabolite;
mouse metabolite
testosterone enanthate[no description available]low00heptanoate ester;
sterol ester		androgen
androstenediol[no description available]low0017beta-hydroxy steroid;
3beta-hydroxy-Delta(5)-steroid		androgen;
human metabolite;
mouse metabolite;
radiation protective agent
dihydrotestosterone[no description available]low0017beta-hydroxy steroid;
17beta-hydroxyandrostan-3-one;
3-oxo-5alpha-steroid		androgen;
Daphnia magna metabolite;
human metabolite;
mouse metabolite
stanozolol[no description available]low0017beta-hydroxy steroid;
anabolic androgenic steroid;
organic heteropentacyclic compound;
tertiary alcohol		anabolic agent;
androgen
calusterone[no description available]medium003-hydroxy steroidandrogen
16-hydroxytestosterone[no description available]low0016alpha-hydroxy steroid;
17beta-hydroxy steroid;
3-oxo-Delta(4) steroid;
androstanoid;
C19-steroid;
diol;
secondary alcohol		androgen
clostebol[no description available]medium003-hydroxy steroidandrogen
androstan-3-ol[no description available]medium003-hydroxy steroidandrogen
d-4-chloro-17 beta-hydroxy-3-oxo-17 alpha-methylandrosta-1,4-diene[no description available]medium003-hydroxy steroidandrogen
11-ketoetiocholanolone[no description available]medium003-hydroxy steroidandrogen
bolasterone[no description available]medium003-hydroxy steroidandrogen
11-hydroxyandrostenedione[no description available]medium003-hydroxy steroidandrogen
4-androstene-3,17-diol[no description available]medium003-hydroxy steroidandrogen
adrenosterone[no description available]low0011-oxo steroid;
17-oxo steroid;
3-oxo-Delta(4) steroid;
androstanoid		androgen;
EC 1.1.1.146 (11beta-hydroxysteroid dehydrogenase) inhibitor;
human urinary metabolite;
marine metabolite
methandriol[no description available]medium003-hydroxy steroidandrogen
nandrolone phenpropionate[no description available]low003-phenylpropionate esteranabolic agent;
androgen
stenbolone[no description available]medium003-hydroxy steroidandrogen
15-hydroxytestosterone[no description available]low0015alpha-hydroxy steroid;
17beta-hydroxy steroid;
3-oxo-Delta(4) steroid;
androstanoid		androgen;
Daphnia magna metabolite
epietiocholanolone[no description available]low0017-oxo steroid;
3beta-hydroxy steroid;
androstanoid		androgen;
animal metabolite;
human blood serum metabolite;
mouse metabolite;
rat metabolite
mibolerone[no description available]low0017beta-hydroxy steroid;
3-oxo-Delta(4) steroid		anabolic agent;
androgen
metribolone[no description available]low0017beta-hydroxy steroid;
3-oxo steroid;
anabolic androgenic steroid		androgen
epiandrosterone[no description available]low0017-oxo steroid;
3beta-hydroxy steroid;
androstanoid		androgen;
human metabolite
methenolone[no description available]medium003-hydroxy steroidandrogen
11-ketotestosterone[no description available]low0011-oxo steroid;
17beta-hydroxy steroid;
3-oxo-Delta(4) steroid;
androstanoid		androgen;
human metabolite;
marine xenobiotic metabolite
pregna-4,17-diene-3,16-dione[no description available]medium003-hydroxy steroidandrogen
tipredane[no description available]medium003-hydroxy steroidandrogen
5-androstene-3,16,17-triol[no description available]medium003-hydroxy steroidandrogen
11 beta-hydroxyandrosterone[no description available]medium003-hydroxy steroidandrogen
quinbolone[no description available]medium003-hydroxy steroidandrogen
3beta-hydroxy-17-(1h-benzimidazole-1-yl)androsta-5,16-diene[no description available]medium003-hydroxy steroidandrogen
estriol[no description available]low0016alpha-hydroxy steroid;
17beta-hydroxy steroid;
3-hydroxy steroid		estrogen;
human metabolite;
human xenobiotic metabolite;
mouse metabolite
estrone[no description available]low0017-oxo steroid;
3-hydroxy steroid;
phenolic steroid;
phenols		antineoplastic agent;
bone density conservation agent;
estrogen;
human metabolite;
mouse metabolite
17-desoxyestradiol[no description available]low003-hydroxy steroid;
phenolic steroid;
phenols		estrogen
estetrol[no description available]low0015alpha-hydroxy steroid;
16alpha-hydroxy steroid;
17beta-hydroxy steroid;
3-hydroxy steroid;
steroid hormone		estrogen receptor agonist;
estrogen;
human metabolite;
human xenobiotic metabolite;
oral contraceptive
androstane-3,17-diol[no description available]low0017-hydroxy steroid;
3-hydroxy steroid;
androstanoid
17-methylestradiol[no description available]low003-hydroxy steroid
2-methoxyestradiol[no description available]low0017beta-hydroxy steroid;
3-hydroxy steroid		angiogenesis modulating agent;
antimitotic;
antineoplastic agent;
human metabolite;
metabolite;
mouse metabolite
estradiol 17-sulfate[no description available]low003-hydroxy steroid;
phenolic steroid;
steroid sulfate		human urinary metabolite
11-beta-chloromethyl-estradiol[no description available]low003-hydroxy steroid
alfatradiol[no description available]low0017alpha-hydroxy steroid;
3-hydroxy steroid;
estradiol		estrogen;
geroprotector
4-methoxyestradiol[no description available]low0017beta-hydroxy steroid;
3-hydroxy steroid;
aromatic ether;
phenols		estrogen;
human metabolite;
rat metabolite
1,3,5,(10),16-estratetraen-3-ol[no description available]low003-hydroxy steroid
fulvestrant[no description available]low0017beta-hydroxy steroid;
3-hydroxy steroid;
organofluorine compound;
sulfoxide		antineoplastic agent;
estrogen antagonist;
estrogen receptor antagonist
ici 164384[no description available]low0017beta-hydroxy steroid;
3-hydroxy steroid;
tertiary carboxamide		anti-estrogen;
antineoplastic agent;
estrogen receptor antagonist
estriol-16 alpha-glucuronide[no description available]low0017beta-hydroxy steroid;
3-hydroxy steroid;
beta-D-glucosiduronic acid;
phenols;
steroid glucosiduronic acid		human urinary metabolite
equilin[no description available]low0017-oxo steroid;
3-hydroxy steroid
stigmastanol[no description available]low003-hydroxy steroid;
phytosterols		anticholesteremic drug;
plant metabolite
16-ketoestrone[no description available]low003-hydroxy steroid
2-methoxyestrone[no description available]low0017-oxo steroid;
3-hydroxy steroid;
alicyclic ketone;
aromatic ether;
phenolic steroid;
phenols		human metabolite;
mouse metabolite
equilenin[no description available]low0017-oxo steroid;
3-hydroxy steroid		antioxidant;
mammalian metabolite
trilostane[no description available]low0017beta-hydroxy steroid;
3-hydroxy steroid;
androstanoid;
epoxy steroid;
nitrile		abortifacient;
antineoplastic agent;
EC 1.1.1.210 [3beta(or 20alpha)-hydroxysteroid dehydrogenase] inhibitor
estradiol-17 beta-glucuronide[no description available]low003-hydroxy steroid;
steroid glucosiduronic acid
tetrahydrogestrinone[no description available]low003-hydroxy steroid
ru 58668[no description available]low0017beta-hydroxy steroid;
3-hydroxy steroid;
aromatic ether;
organofluorine compound;
sulfone		anti-estrogen;
antineoplastic agent;
estrogen receptor antagonist
4-hydroxyestrone[no description available]low0017-oxo steroid;
3-hydroxy steroid;
4-hydroxy steroid;
catechols;
phenolic steroid		carcinogenic agent;
estrogen;
human urinary metabolite
altrenogest[no description available]low003-hydroxy steroid
moxestrol[no description available]low003-hydroxy steroid
ConditionIndicatedRelationship StrengthStudiesTrials
Abnormalities, Autosome0low10
Abnormalities, Chromosomal0low10
Abnormalities, Chromosome0low10
Actinic Reticuloid Syndrome0low10
Acute Disease0low10
Acute Edematous Pancreatitis0low10
Acute Liver Injury, Drug-Induced0low10
Acute Pancreatitis0low10
Adenocarcinoma0low110
Adenocarcinoma, Basal Cell0low110
Adenocarcinoma, Granular Cell0low110
Adenocarcinoma, Oxyphilic0low110
Adenocarcinoma, Tubular0low110
Adenoma0low10
Adenoma, Basal Cell0low10
Adenoma, Follicular0low10
Adenoma, Malignant0low110
Adenoma, Microcystic0low10
Adenoma, Monomorphic0low10
Adenoma, Papillary0low10
Adenoma, Trabecular0low10
Adrenal Gland Hypofunction0low10
Adrenal Insufficiency0low10
Alopecia0low10
Alopecia Cicatrisata0low10
Alopecia, Androgenetic0low10
Alopecia, Male Pattern0low10
Amenorrhea0low20
Androgenetic Alopecia0low10
Androgenic Alopecia0low10
Anxiety0medium11
Arteriosclerosis0low10
Atypical Endometrial Hyperplasia0low30
Autosome Abnormalities0low10
Baldness0low10
Baldness, Male Pattern0low10
Behavior Disorders0medium11
Benign Neoplasms0low10
Bilateral Headache0medium42
Bleeding0medium21
Bleeding Between Periods0low10
Blood Clot0low10
Blood Pressure, High0low20
Body Weight0medium53
Bone Loss, Osteoclastic0low10
Bone Resorption0low10
Bonnevie-Ullrich Syndrome0low10
Breakthrough Bleeding0low10
Breast Cancer0low20
Breast Carcinoma0low20
Breast Diseases0medium11
Breast Neoplasms0low20
Breast Tumors0low20
Cancer0low10
Cancer of Breast0low20
Cancer of Liver0low20
Cancer of Lung0low20
Cancer of the Breast0low20
Cancer of the Liver0low20
Cancer of the Lung0low20
Cancer of the Uterus0low160
Cancer of Uterus0low160
Cancer, Hepatocellular0low20
Candidiasis, Genital0low10
Candidiasis, Vulvovaginal0low10
Carcinoma in Situ0low10
Carcinoma, Cribriform0low110
Carcinoma, Epidermoid0low10
Carcinoma, Granular Cell0low110
Carcinoma, Hepatocellular0low20
Carcinoma, Intraepithelial0low10
Carcinoma, Planocellular0low10
Carcinoma, Preinvasive0low10
Carcinoma, Squamous0low10
Carcinoma, Squamous Cell0low10
Carcinoma, Tubular0low110
Cardiovascular Stroke0low10
Cephalalgia0medium42
Cephalgia0medium42
Cephalodynia0medium42
Chemical and Drug Induced Liver Injury0low10
Chemically-Induced Liver Toxicity0low10
Cholera Infantum0medium11
Chromosomal Aberrations0low10
Chromosome Aberrations0low10
Chromosome Abnormalities0low10
Chronic Actinic Dermatitis0low10
Compensatory Hyperinsulinemia0low10
Complex Endometrial Hyperplasia0low30
Complications, Pregnancy0low30
Condition, Preneoplastic0low20
Conditions, Preneoplastic0low20
Congenital Zika Syndrome0low10
Congenital Zika Virus Infection0low10
Cranial Pain0medium42
Cytogenetic Aberrations0low10
Cytogenetic Abnormalities0low10
Depression0medium22
Dermatitis Medicamentosa0medium11
Dermatitis, Actinic0low10
Dermatitis, Adverse Drug Reaction0medium11
Diabetes Mellitus0low10
Diagnosis, Psychiatric0medium11
Disease0low20
Disease Models, Animal0low10
Diseases in Twins0low10
Drug Eruptions0medium11
Drug-Induced Acute Liver Injury0low10
Drug-Induced Liver Disease0low10
Drug-Induced Liver Injury0low10
Dysfunctional Uterine Bleeding0low10
Dysmenorrhea0low10
Edema-Proteinuria-Hypertension Gestosis0low10
Emesis0medium22
Endocrine Breast Diseases0medium11
Endogenous Hyperinsulinism0low10
Endometrial Hyperplasia0low30
EPH Complex0low10
EPH Gestosis0low10
EPH Toxemias0low10
Esophageal Reflux0low10
Exogenous Hyperinsulinism0low10
Female Pattern Baldness0low10
Fetal Death0low10
Fetal Demise0low10
Fetal Mummification0low10
Fever, Zika0low10
Fibroid0low10
Fibroid Tumor0low10
Fibroid Uterus0low10
Fibroids, Uterine0low10
Fibroma, Uterine0low10
Fibromyoma0low10
Foreign-Body Reaction0low10
Functional Gastrointestinal Disorders0medium11
Gastric Acid Reflux0low10
Gastric Acid Reflux Disease0low10
Gastro-Esophageal Reflux0low10
Gastro-Esophageal Reflux Disease0low10
Gastro-oesophageal Reflux0low10
Gastroesophageal Reflux0low10
Gastroesophageal Reflux Disease0low10
Gastrointestinal Diseases0medium11
Gastrointestinal Disorders0medium11
Gastrointestinal Disorders, Functional0medium11
Generalized Headache0medium42
Genital Vulvovaginal Candidiasis0low10
GERD0low10
Gestosis, EPH0low10
Gonadal Dysgenesis, 45,X0low10
Gonadal Dysgenesis, XO0low10
Hair Loss0low10
Head Pain0medium42
Headache0medium42
Heart Attack0low10
Heavy Menstrual Bleeding0low10
Heavy Periods0low10
Hemicrania0medium42
Hemoperitoneum0low10
Hemorrhage0medium21
Hepatic Cancer0low20
Hepatic Neoplasms0low20
Hepatitis, Drug-Induced0low10
Hepatitis, Toxic0low10
Hepatocellular Cancer0low20
Hepatocellular Carcinoma0low20
Hepatoma0low20
Human Mammary Carcinoma0low20
Hyperinsulinemia0low10
Hyperinsulinism0low10
Hyperlipemia0low10
Hyperlipidemia0low10
Hyperlipidemias0low10
Hypermenorrhea0low10
Hyperplasia0low20
Hypertension0low20
Hypertension-Edema-Proteinuria Gestosis0low10
Hyperthyroid0low10
Hyperthyroidism0low10
Hypoadrenalism0low10
Hypomenorrhea0medium31
Infertility0low10
Infertility, Female0low20
Intermenstrual Bleeding0low10
Intraepithelial Neoplasms0low10
Irregular Menses0medium31
Irregular Menstruation0medium31
Leiomyoma0low10
Leiomyoma, Uterine0low10
Lipemia0low10
Lipidemia0low10
Liver Cancer0low20
Liver Cancer, Adult0low20
Liver Cell Carcinoma0low20
Liver Cell Carcinoma, Adult0low20
Liver Diseases0low10
Liver Dysfunction0low10
Liver Injury, Drug-Induced0low10
Liver Injury, Drug-Induced, Acute0low10
Liver Neoplasms0low20
Local Neoplasm Recurrence0low10
Local Neoplasm Recurrences0low10
Locoregional Neoplasm Recurrence0low10
Long Sleeper Syndrome0low10
Lung Cancer0low20
Lung Neoplasms0low20
Maculopapular Drug Eruption0medium11
Maculopapular Exanthem0medium11
Male Pattern Baldness0low10
Malignancy0low10
Malignant Neoplasm of Breast0low20
Malignant Neoplasms0low10
Malignant Tumor of Breast0low20
Mammary Cancer0low20
Mammary Carcinoma, Human0low20
Mammary Neoplasm, Human0low20
Mammary Neoplasms, Human0low20
Menopause0low30
Menorrhagia0low10
Menstrual Irregularities0medium31
Menstrual Irregularity0medium31
Menstruation Disorders0medium31
Menstruation Disturbances0medium31
Menstruation, Painful0low10
Menstruation, Retrograde0medium31
Mental Disorders0medium11
Mental Disorders, Severe0medium11
Mental Illness0medium11
Metastase0low40
Metastases, Neoplasm0low40
Metastasis0low40
Metastasis, Neoplasm0low40
Metrorrhagia0low10
Moniliasis, Vulvovaginal0low10
Monosomy X0low10
Morbilliform Drug Reaction0medium11
Morbilliform Exanthem0medium11
Muscle Contraction0low10
Myocardial Infarct0low10
Myocardial Infarction0low10
Myxedema0low10
Nausea0medium22
Neoplasia0low10
Neoplasm0low10
Neoplasm Metastases0low40
Neoplasm Metastasis0low40
Neoplasm Recurrence, Local0low10
Neoplasm Recurrence, Locoregional0low10
Neoplasm Recurrences, Local0low10
Neoplasms0low10
Neoplasms, Benign0low10
Neoplasms, Breast0low20
Neoplasms, Hepatic0low20
Neoplasms, Intraepithelial0low10
Neoplasms, Liver0low20
Neoplasms, Lung0low20
Neoplasms, Pulmonary0low20
Neoplasms, Uterine0low160
Neoplasms, Uterus0low160
Nutrition Disorders0low10
Nutritional Disorders0low10
Obesity0low20
Ocular Headache0medium42
Orthostatic Headache0medium42
Osteoclastic Bone Loss0low10
Pain, Menstrual0low10
Pancreatic Parenchyma with Edema0low10
Pancreatic Parenchymal Edema0low10
Pancreatitis0low10
Pancreatitis, Acute0low10
Pancreatitis, Acute Edematous0low10
Paranoia0low10
Paranoid Disorders0low10
Paranoid Psychoses0low10
Pattern Baldness0low10
Periorbital Headache0medium42
Peripancreatic Fat Necrosis0low10
Photodermatitis0low10
Photosensitivity Disorders0low10
Photosensitization0low10
Polycystic Ovarian Syndrome0low10
Polycystic Ovary Syndrome0low10
Polycystic Ovary Syndrome 10low10
Polymenorrhea0medium31
Porphyria0low10
Porphyrias0low10
Porphyrin Disorder0low10
Postpartum Amenorrhea0low20
Pre-Eclampsia0low10
Precancerous Conditions0low20
Prediabetes0low10
Prediabetic State0low10
Preeclampsia0low10
Preeclampsia Eclampsia 10low10
Pregnancy0medium152
Pregnancy Complications0low30
Pregnancy Toxemias0low10
Premenstrual Syndrome0low10
Premenstrual Tension0low10
Preneoplastic Condition0low20
Preneoplastic Conditions0low20
Primary Hyperthyroidism0low10
Proteinuria-Edema-Hypertension Gestosis0low10
Pseudopelade0low10
Psychiatric Diagnosis0medium11
Psychiatric Diseases0medium11
Psychiatric Disorders0medium11
Psychiatric Illness0medium11
Psychoses, Drug0low10
Psychoses, Paranoid0low10
Psychoses, Substance-Induced0low10
Psychoses, Toxic0low10
Puerperal Disorders0low10
Pulmonary Cancer0low20
Pulmonary Neoplasms0low20
Recrudescence0low10
Recurrence0low10
Recurrence, Local Neoplasm0low10
Recurrence, Locoregional Neoplasm0low10
Recurrences, Local Neoplasm0low10
Reflux, Gastroesophageal0low10
Relapse0low10
Reproductive Sterility0low10
Retro-Ocular Headache0medium42
Rupture, Spontaneous0low10
Sclerocystic Ovarian Degeneration0low10
Sclerocystic Ovaries0low10
Sclerocystic Ovary Syndrome0low10
Sharp Headache0medium42
Short Sleep Phenotype0low10
Short Sleeper Syndrome0low10
Signs and Symptoms0low10
Simple Endometrial Hyperplasia0low30
Sleep Disorders0low10
Sleep Wake Disorders0low10
Sleep-Related Neurogenic Tachypnea0low10
Spotting0low10
Squamous Cell Carcinoma0low10
Status Bonnevie-Ullrich0low10
Stein-Leventhal Syndrome0low10
Sterility0low10
Sterility, Female0low20
Sterility, Postpartum0low20
Sterility, Reproductive0low10
Sub-Fertility0low10
Sub-Fertility, Female0low20
Subfertility0low10
Subfertility, Female0low20
Substance-Induced Psychoses0low10
Subwakefullness Syndrome0low10
Throbbing Headache0medium42
Thrombosis0low10
Thrombus0low10
Toxemia Of Pregnancy0low10
Toxemias, Pregnancy0low10
Toxic Hepatitis0low10
Toxic Psychoses0low10
Tumors0low10
Tumors, Breast0low20
Turner Syndrome0low10
Turner's Syndrome0low10
Ullrich-Turner Syndrome0low10
Unilateral Headache0medium42
Uterine Cancer0low160
Uterine Neoplasms0low160
Uterus Cancer0low160
Uterus Neoplasms0low160
Vaginal Yeast Infection0low10
Vaginal Yeast Infections0low10
Vaginitis, Monilial0low10
Vertex Headache0medium42
Vomiting0medium22
Zika Fever0low10
Zika Virus Disease0low10
Zika Virus Infection0low10
ZikV Infection0low10

Research Highlights

Long-term Use (2)

ArticleYear
Severe atypical endometrial changes and sequential contraceptive use.
JAMA, Aug-23, Volume: 236, Issue: 8		1976
The development of adenocarcinoma of the endometrium in young women receiving long-term sequential oral contraception.
American journal of obstetrics and gynecology, Oct-01, Volume: 123, Issue: 3		1975
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioavailability (1)

ArticleYear
Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens.
The Journal of biological chemistry, 11-15, Volume: 294, Issue: 46		2019
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]