Poisonous substance produced by a biological organism such as a microbe, animal or plant.
| Member | Definition | Class |
|---|
| 3-octanone | A dialkyl ketone that is octane in which the two methylene protons at position 3 have been replaced by an oxo group. | 3-octanone |
| acetopyrrothine | A dithiolopyrrolone antibiotic that is 4,5-dihydro[1,2]dithiolo[4,3-b]pyrrole in which the hydrogens at positions 4,5 and 6 have been replaced by methyl, oxo and acetamido groups, respectively. It is a potent inhibitor of RNA polymerases, inhibits the angiogenesis of human umbilical vein endothelial cells, and also inhibits JAMM metalloproteases. | thiolutin |
| acrolein | An enal that is prop-2-ene with an oxo group at position 1. | acrolein |
| aristolochic acid c | An aristolochic acid that is phenanthrene-1-carboxylic acid substituted by a methylenedioxy group at the 3,4 positions, by an hydroxy group at position 6, and by a nitro group at position 10. | aristolochic acid C |
| aristolochic acid D | An aristolochic acid that is phenanthrene-1-carboxylic acid substituted by a methylenedioxy group at the 3,4 positions, by an hydroxy group at position 6, by a methoxy group at position 8, and by a nitro group at position 10. | aristolochic acid D |
| aristolochic acid i | An aristolochic acid that is phenanthrene-1-carboxylic acid that is substituted by a methylenedioxy group at the 3,4 positions, by a methoxy group at position 8, and by a nitro group at position 10. It is the most abundant of the aristolochic acids and is found in almost all Aristolochia (birthworts or pipevines) species. It has been tried in a number of treatments for inflammatory disorders, mainly in Chinese and folk medicine. However, there is concern over their use as aristolochic acid is both carcinogenic and nephrotoxic. | aristolochic acid A |
| aristolochic acid ii | An aristolochic acid that is phenanthrene-1-carboxylic acid substituted by a methylenedioxy group at the 3,4 positions and by a nitro group at position 10. | aristolochic acid B |
| bafilomycin a1 | The most used of the bafilomycins, a family of toxic macrolide antibiotics derived from Streptomyces griseus. | bafilomycin A1 |
| biliatresone | A member of the class of benzodioxoles that is 1,3-benzodioxole which is substituted at positions 5 by a 2-(2-hydroxyphenyl)-3-oxoprop-1-en-3-yl group and at positions 4 and 6 by methoxy groups. A very rare type of isoflavonoid-related 1,2-diaryl-2-propenone found in Dysphania glomulifera (red crumbweed) and D. littoralis, the enone moiety is particularly reactive, undergoing ready Michael addition of water and methanol. Biliatresone has been found to cause extrahepatic biliary atresia (obliteration or discontinuity of the extrahepatic biliary system, resulting in obstruction to bile flow) in a zebrafish model. | biliatresone |
| bongkrekic acid | A tricarboxylic acid that is docosa-2,4,8,10,14,18,20-heptaenedioic acid substituted at positions 2 ,5 and 17 by methyl groups, at positions 6 by a methoxy group and at position 20 by a carboxymethyl group. It is produced by the bacterium Burkholderia gladioli and implicated in outbreaks of food-borne illness involving coconut and corn-based products in Indonesia and China. | bongkrekic acid |
| decarbamylsaxitoxin | A pyrrolopurine that is 2,6-diiminodecahydropyrrolo[1,2-c]purine carrying an additional hydroxymethyl substituent at position 4 as well as two hydroxy substituents at position 10. A toxin that is isolated from marine dinoflagellates and cyanobacteria and is known to cause paralytic shellfish poisoning. | decarbamoylsaxitoxin |
| dinophysistoxin 1 | A ketal that is a marine toxin structurally related to okadaic acid. Produced by dinoflagellates it is known to accumulate in shellfish and cause diarrhoeic shellfish poisoning. It is an inhibitor of serine/threonine protein phosphatases 1 (PP1) and PP2A and has been shown to promote cancer cell growth in tumour cell lines and animal models. | dinophysistoxin 1 |
| dinophysistoxin 2 | A ketal that is a rare marine toxin structurally related to okadaic acid. Found yearly along with okadaic acid in Portuguese shellfish, its presence has been correlated with the occurrence of Dinophysis acta. | dinophysistoxin 2 |
| djenkolic acid | A dithioacetal consisting of two molecules of L-cysteine joined via their sulfanyl groups to methylene. | L-djenkolic acid |
| dysidenin | A secondary carboxamide resulting from the formal condensation of the carboxy group of (4S)-5,5,5-trichloro-N-methyl-N-[(3S)-4,4,4-trichloro-3-methylbutanoyl]-L-leucine with the amino group of (1S)-1-(1,3-thiazol-2-yl)ethanamine. It is a marine metabolite initially isolated from the sponge dysidea herbacea. | dysidenin |
| ergonovine | A monocarboxylic acid amide that is lysergamide in which one of the hydrogens attached to the amide nitrogen is substituted by a 1-hydroxypropan-2-yl group (S-configuration). An ergot alkaloid that has a particularly powerful action on the uterus, its maleate (and formerly tartrate) salt is used in the active management of the third stage of labour, and to prevent or treat postpartum of postabortal haemorrhage caused by uterine atony: by maintaining uterine contraction and tone, blood vessels in the uterine wall are compressed and blood flow reduced. | ergometrine |
| ethylene glycol | A 1,2-glycol compound produced via reaction of ethylene oxide with water. | ethylene glycol |
| galactosamine | The pyranose form of D-galactosamine. | 2-amino-2-deoxy-D-galactopyranose |
| hydrogen sulfide | A sulfur hydride consisting of a single sulfur atom bonded to two hydrogen atoms. A highly poisonous, flammable gas with a characteristic odour of rotten eggs, it is often produced by bacterial decomposition of organic matter in the absence of oxygen. | hydrogen sulfide |
| latrunculin a | A bicyclic macrolide natural product consisting of a 16-membered bicyclic lactone attached to the rare 2-thiazolidinone moiety. It is obtained from the Red Sea sponge Latrunculia magnifica and from the Fiji Islands sponge Cacospongia mycofijiensis. Latrunculin A inhibits actin polymerisation, microfilament organsation and microfilament-mediated processes. | latrunculin A |
| latrunculin b | A macrolide consisting of a 14-membered bicyclic lactone attached to the rare 2-thiazolidinone moiety. It is obtained from the Red Sea sponge Latrunculia magnifica. | latrunculin B |
| mitomycin a | A member of the family of mitomycins that exhibits antibiotic and antitumour properties as well as a high level of toxicity. | mitomycin A |
| nereistoxin | Toxin isolated from marine segmented worm, Lumbriconereis heterodopa. It is also the active insecticide of the proinsecticide thiocyclam. | nereistoxin |
| neriifolin | A cardenolide glycoside that is digitoxigenin in which the hydroxy goup at position 3 has been converted to its (6-deoxy-3-O-methyl-alpha-L-glucopyranoside derivative. Found in the seeds of Cerbera odollamand in Thevetia ahouia and Thevitia neriifolia. | neriifolin |
| palytoxin | A polyol marine coelenterate toxin composed of substituted N-3-hydroxypropyl-trans-3-amidoacrylamides and produced by species of Palythoa and Zoanthus soft corals (collectively called zoantharians), either as a defence mechanism or to assist them in capturing prey. An ionophore that forms cation channels through Na+/K+-ATPase, it is a potent vasoconstrictor useful in evaluation of anti-angina agents. It is considered to be one of the most poisonous non-protein substances known, second only to maitotoxin in terms of toxicity in mice. | palytoxin |
| phenylacetic acid | A monocarboxylic acid that is toluene in which one of the hydrogens of the methyl group has been replaced by a carboxy group. | phenylacetic acid |
| rotenone | A member of the class of rotenones that consists of 1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one substituted at position 2 by a prop-1-en-2-yl group and at positions 8 and 9 by methoxy groups (the 2R,6aS,12aS-isomer). A non-systemic insecticide, it is the principal insecticidal constituent of derris (the dried rhizome and root of Derris elliptica). | rotenone |
| saxitoxin | An alkaloid isolated from the marine dinoflagellates and cyanobacteria that causes paralytic shellfish poisoning. | saxitoxin |
| solanidine | | solanidine |
| tabtoxin | A monobactam phytotoxic dipeptide produced by Pseudomonas syringae, that causes wildfire disease in tobacco. | tabtoxin |
| tilimycin | A pyrrolobenzodiazepine that is (11aS)-2,3,5,10,11,11a-hexahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine which is substituted by an oxo group at position 5 and by hydroxy groups at positions 9 and 11. It is an enterotoxic natural product synthesized via a non-ribosomal peptide synthase in Klebsiella oxytoca. | tilimycin |
| tilivalline | A pyrrolobenzodiazepine that is (11aS)-2,3,5,10,11,11a-hexahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine substituted by an oxo group at position 5, by a hydroxy group at position 9, and by a 1H-indol-3-yl group at position 11S. It is a natural product discovered in Klebsiella oxytoca which is the causative toxin in antibiotic associated hemorrhagic colitis. It exhibits a microtubule-stabilizing activity that leads to mitotic arrest in the host cells. | tilivalline |
| tobramycin | A amino cyclitol glycoside that is kanamycin B lacking the 3-hydroxy substituent from the 2,6-diaminoglucose ring. | tobramycin |
| toxoflavin | A pyrimidotriazine that is 1,6-dimethyl-1,5,6,7-tetrahydropyrimido[5,4-e][1,2,4]triazine with oxo groups at positions 5 and 7. | toxoflavin |
| tropodithietic acid | A monocarboxylic acid that is 8,9-dithiabicyclo[5.2.0]nona-1,3,6-triene substituted by a carboxy group at position 2 and an oxo group at position 3. It is a broad spectrum antibiotic produced by the marine bacterium Phaeobacter inhibens that also acts as a signalling molecule at lower concentrations. | tropodithietic acid |
| tropolone | A cyclic ketone that is cyclohepta-2,4,6-trien-1-one substituted by a hydroxy group at position 2. It is a toxin produced by the agricultural pathogen Burkholderia plantarii. | tropolone |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 4-(cytidine 5'-phospho)-2-C-methyl-D-erithritol kinase | Arabidopsis thaliana (thale cress) | Potency | 1.1873 | 1 | 1 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 90.4529 | 1 | 1 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 25.0255 | 1 | 1 |
| Adenosine receptor A1 | Rattus norvegicus (Norway rat) | Potency | 1.2589 | 1 | 1 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 29.9577 | 1 | 6 |
| AR protein | Homo sapiens (human) | Potency | 8.5040 | 11 | 26 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 33.4630 | 1 | 1 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 3.3720 | 2 | 2 |
| Ataxin-2 | Homo sapiens (human) | Potency | 0.2512 | 1 | 1 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 0.8492 | 1 | 1 |
| atrial natriuretic peptide receptor 1 precursor | Homo sapiens (human) | Potency | 0.1346 | 1 | 1 |
| atrial natriuretic peptide receptor 2 precursor | Homo sapiens (human) | Potency | 0.0826 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 15.2988 | 2 | 3 |
| Caspase-1 | Homo sapiens (human) | Potency | 2.3661 | 3 | 3 |
| caspase-1 isoform alpha precursor | Homo sapiens (human) | Potency | 7.2923 | 2 | 2 |
| Caspase-7 | Homo sapiens (human) | Potency | 3.7636 | 3 | 3 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 0.2511 | 3 | 7 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 2.9031 | 2 | 2 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 21.8959 | 1 | 2 |
| Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 4.0871 | 1 | 2 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 22.3872 | 1 | 1 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 11.1418 | 3 | 4 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 11.2202 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 22.3367 | 1 | 2 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 9.6464 | 3 | 4 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 0.0050 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 62.3032 | 2 | 2 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 1.0000 | 1 | 1 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 6.1655 | 1 | 1 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 15.4871 | 1 | 1 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 8.8320 | 2 | 7 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 5.4950 | 1 | 1 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 28.0005 | 1 | 4 |
| D(1A) dopamine receptor | Sus scrofa (pig) | Potency | 0.0465 | 1 | 1 |
| DNA dC->dU-editing enzyme APOBEC-3F isoform a | Homo sapiens (human) | Potency | 7.9433 | 1 | 1 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 64.4679 | 1 | 2 |
| DNA polymerase eta isoform 1 | Homo sapiens (human) | Potency | 3.0331 | 2 | 2 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 13.8552 | 2 | 2 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 11.0686 | 10 | 31 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 13.9934 | 2 | 4 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 16.0940 | 9 | 29 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 18.1837 | 1 | 2 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 2.6196 | 4 | 4 |
| eyes absent homolog 2 isoform a | Homo sapiens (human) | Potency | 741.5113 | 2 | 2 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 21.9534 | 1 | 3 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 56.2341 | 1 | 1 |
| fructose-bisphosphate aldolase A | Oryctolagus cuniculus (rabbit) | Potency | 4.4668 | 1 | 1 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 3.3173 | 1 | 1 |
| G | Vesicular stomatitis virus | Potency | 6.1655 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 8.9780 | 1 | 4 |
| galactokinase | Homo sapiens (human) | Potency | 1.1586 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 8.9780 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 8.9780 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 8.9780 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 8.9780 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 8.9780 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 8.9780 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 8.9780 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 8.9780 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 8.9780 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 8.9780 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 8.9780 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 8.9780 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 8.9780 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 8.9780 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 8.9780 | 1 | 4 |
| geminin | Homo sapiens (human) | Potency | 4.6832 | 4 | 10 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 7.7789 | 2 | 7 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 15.5011 | 1 | 2 |
| GLS protein | Homo sapiens (human) | Potency | 11.9048 | 2 | 2 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 29.8826 | 5 | 9 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 0.0300 | 1 | 3 |
| glyceraldehyde-3-phosphate dehydrogenase isoform 1 | Homo sapiens (human) | Potency | 2.5119 | 1 | 1 |
| GTP-binding nuclear protein Ran isoform 1 | Homo sapiens (human) | Potency | 6.5131 | 1 | 1 |
| Guanine nucleotide-binding protein G | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 53.0946 | 2 | 4 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 31.6228 | 1 | 3 |
| Histamine H3 receptor | Rattus norvegicus (Norway rat) | Potency | 3.9811 | 1 | 3 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 44.2698 | 2 | 2 |
| histone-lysine N-methyltransferase 2A isoform 2 precursor | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 6.1655 | 1 | 1 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 5.0119 | 1 | 1 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 36.8367 | 1 | 3 |
| IDH1 | Homo sapiens (human) | Potency | 0.5174 | 1 | 1 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 17.3484 | 2 | 2 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 6.1655 | 1 | 2 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 28.3708 | 1 | 2 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 0.7943 | 1 | 1 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 0.7943 | 1 | 1 |
| Interferon beta | Homo sapiens (human) | Potency | 4.9974 | 3 | 5 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 2.3057 | 2 | 4 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 5.8562 | 1 | 3 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 19.2886 | 1 | 2 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 13.6853 | 2 | 8 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 2.2387 | 1 | 1 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 3.3975 | 3 | 4 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 24.9054 | 1 | 2 |
| NPC intracellular cholesterol transporter 1 precursor | Homo sapiens (human) | Potency | 146.1708 | 1 | 2 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 26.4314 | 3 | 14 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 5.8828 | 1 | 2 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 38.7363 | 1 | 5 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 4.6813 | 4 | 12 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 20.4432 | 3 | 9 |
| P53 | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 16.1948 | 1 | 2 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 7.5084 | 1 | 2 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 0.0683 | 2 | 2 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 0.0478 | 1 | 1 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 26.8039 | 4 | 7 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 26.1634 | 3 | 5 |
| phosphoglycerate kinase | Trypanosoma brucei brucei TREU927 | Potency | 1.2893 | 2 | 2 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 40.4392 | 1 | 2 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 7.6237 | 1 | 2 |
| polyprotein | Zika virus | Potency | 3.3173 | 1 | 1 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| PPM1D protein | Homo sapiens (human) | Potency | 1.8557 | 1 | 2 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 32.5497 | 2 | 3 |
| progesterone receptor | Homo sapiens (human) | Potency | 20.4580 | 2 | 5 |
| Rap guanine nucleotide exchange factor 3 | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| Rap guanine nucleotide exchange factor 4 | Homo sapiens (human) | Potency | 63.0957 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 9.8244 | 2 | 9 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 25.1073 | 1 | 3 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 21.1923 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 13.9405 | 3 | 11 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 5.1105 | 4 | 8 |
| serine-protein kinase ATM isoform a | Homo sapiens (human) | Potency | 0.8913 | 1 | 1 |
| serine/threonine-protein kinase mTOR isoform 1 | Homo sapiens (human) | Potency | 0.0525 | 2 | 2 |
| serine/threonine-protein kinase PLK1 | Homo sapiens (human) | Potency | 21.1923 | 1 | 1 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 0.1077 | 1 | 3 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 0.1077 | 1 | 3 |
| Smad3 | Homo sapiens (human) | Potency | 0.1122 | 1 | 1 |
| snurportin-1 | Homo sapiens (human) | Potency | 17.3484 | 2 | 2 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 0.0341 | 1 | 1 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 5.0316 | 1 | 2 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 13.3745 | 2 | 14 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 39.0790 | 2 | 3 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 5.8720 | 2 | 9 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 6.3446 | 2 | 2 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 22.6235 | 5 | 15 |
| thyrotropin-releasing hormone receptor | Homo sapiens (human) | Potency | 6.1334 | 1 | 1 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 7.6237 | 1 | 2 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 7.6237 | 1 | 2 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 32.0255 | 2 | 3 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 23.9687 | 2 | 4 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 26.0305 | 2 | 3 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 0.0300 | 1 | 3 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | IC50 | 0.0081 | 1 | 1 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | Ki | 0.0046 | 1 | 1 |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | IC50 | 0.0081 | 1 | 1 |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | Ki | 0.0046 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | IC50 | 0.0022 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | Ki | 0.0006 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | IC50 | 0.0041 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | Ki | 0.0026 | 1 | 1 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | IC50 | 0.0210 | 1 | 1 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | Ki | 0.0110 | 1 | 1 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | IC50 | 0.0210 | 1 | 1 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | Ki | 0.0110 | 1 | 1 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | IC50 | 0.4366 | 1 | 2 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | Ki | 0.2028 | 1 | 2 |
| 72 kDa type IV collagenase | Homo sapiens (human) | IC50 | 146.0000 | 1 | 1 |
| 90-kda heat shock protein beta HSP90 beta, partial | Homo sapiens (human) | IC50 | 1.0566 | 2 | 2 |
| Actin | Saccharomyces cerevisiae S288C | IC50 | 0.0733 | 1 | 3 |
| Actin, alpha skeletal muscle | Oryctolagus cuniculus (rabbit) | IC50 | 8.4700 | 1 | 1 |
| Acyl carrier protein, mitochondrial | Bos taurus (cattle) | IC50 | 0.0051 | 1 | 1 |
| Adenomatous polyposis coli protein | Homo sapiens (human) | Ki | 118.0000 | 2 | 2 |
| Adenosine receptor A3 | Homo sapiens (human) | Ki | 1.0800 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Homo sapiens (human) | IC50 | 96.0000 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Homo sapiens (human) | Ki | 253.0000 | 1 | 3 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | IC50 | 1.6800 | 1 | 1 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | Ki | 0.6300 | 1 | 1 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | IC50 | 0.2890 | 1 | 1 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | Ki | 0.1320 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | Ki | 107.7500 | 2 | 2 |
| ATP-dependent translocase ABCB1 | Mus musculus (house mouse) | Ki | 558.7500 | 2 | 2 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 70.5000 | 1 | 2 |
| Cadherin-1 | Homo sapiens (human) | Ki | 16.5000 | 2 | 2 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| Carbonic anhydrase | Methanosarcina thermophila | Ki | 50.0000 | 1 | 1 |
| Carbonic anhydrase | Methanothermobacter thermautotrophicus str. Delta H | Ki | 700.0000 | 1 | 1 |
| Carbonic anhydrase | Stylophora pistillata | Ki | 3,940.0000 | 1 | 1 |
| Carbonic anhydrase | Stylophora pistillata | Ki | 580.0000 | 1 | 1 |
| Carbonic anhydrase 1 | Homo sapiens (human) | Ki | 0.6000 | 8 | 8 |
| Carbonic anhydrase 13 | Mus musculus (house mouse) | Ki | 5,200.0000 | 1 | 1 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 35.8667 | 9 | 9 |
| Carbonic anhydrase 4 | Homo sapiens (human) | Ki | 3,900.0000 | 1 | 1 |
| Carbonic anhydrase 5A, mitochondrial | Homo sapiens (human) | Ki | 10.0000 | 2 | 2 |
| Carbonic anhydrase 5B, mitochondrial | Homo sapiens (human) | Ki | 10.0000 | 2 | 2 |
| Carbonic anhydrase 6 | Homo sapiens (human) | Ki | 710.0000 | 1 | 1 |
| Carbonic anhydrase 7 | Homo sapiens (human) | Ki | 1,240.0000 | 1 | 1 |
| Carbonic anhydrase 9 | Homo sapiens (human) | Ki | 7.0000 | 1 | 1 |
| Carbonic anhydrase, alpha family | Hydrogenovibrio crunogenus XCL-2 | Ki | 1.1000 | 1 | 1 |
| Carboxypeptidase A1 | Bos taurus (cattle) | IC50 | 2.7300 | 1 | 1 |
| Catenin beta-1 | Homo sapiens (human) | IC50 | 82.9600 | 5 | 5 |
| Catenin beta-1 | Homo sapiens (human) | Ki | 4.7750 | 4 | 4 |
| Cathepsin B | Homo sapiens (human) | IC50 | 0.0467 | 2 | 2 |
| cathepsin S isoform 1 preproprotein | Homo sapiens (human) | IC50 | 0.1765 | 1 | 1 |
| Collagenase ColG | Hathewaya histolytica | IC50 | 46.8000 | 1 | 1 |
| Cyclin-dependent kinase 2 | Homo sapiens (human) | IC50 | 23.7500 | 1 | 4 |
| Cytochrome P450 2C19 | Homo sapiens (human) | IC50 | 3.6486 | 1 | 1 |
| D(1A) dopamine receptor | Homo sapiens (human) | IC50 | 5.9010 | 1 | 1 |
| D(1A) dopamine receptor | Homo sapiens (human) | Ki | 2.9500 | 1 | 1 |
| D(2) dopamine receptor | Homo sapiens (human) | IC50 | 0.5520 | 1 | 1 |
| D(2) dopamine receptor | Homo sapiens (human) | Ki | 0.1840 | 1 | 1 |
| D(3) dopamine receptor | Homo sapiens (human) | IC50 | 0.5670 | 1 | 1 |
| D(3) dopamine receptor | Homo sapiens (human) | Ki | 0.1930 | 1 | 1 |
| Delta-type opioid receptor | Mus musculus (house mouse) | Ki | 9.0000 | 1 | 1 |
| Dihydroorotate dehydrogenase | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 10.0000 | 1 | 1 |
| Dihydroorotate dehydrogenase (fumarate) | Saccharomyces cerevisiae S288C | IC50 | 10.0000 | 1 | 1 |
| Dopamine beta-hydroxylase | Homo sapiens (human) | IC50 | 2.0000 | 1 | 1 |
| dual specificity protein phosphatase 3 | Homo sapiens (human) | IC50 | 1.1700 | 2 | 2 |
| dual specificity protein phosphatase 6 | Rattus norvegicus (Norway rat) | IC50 | 2.3200 | 1 | 1 |
| Endothelial PAS domain-containing protein 1 | Homo sapiens (human) | IC50 | 15.8500 | 2 | 2 |
| green fluorescent protein, partial | Aequorea victoria | IC50 | 67.5490 | 1 | 2 |
| heat shock protein HSP 90-alpha isoform 2 | Homo sapiens (human) | IC50 | 1.0566 | 2 | 2 |
| Hypoxia-inducible factor 1-alpha | Homo sapiens (human) | IC50 | 15.8500 | 2 | 2 |
| Lysine-specific demethylase 4A | Homo sapiens (human) | IC50 | 2.5000 | 2 | 2 |
| Lysine-specific demethylase 4C | Homo sapiens (human) | IC50 | 0.5205 | 2 | 2 |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | Ki | 9.0000 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| NAD-dependent protein deacetylase sirtuin-1 | Homo sapiens (human) | IC50 | 0.8700 | 1 | 1 |
| NAD-dependent protein deacetylase sirtuin-2 | Homo sapiens (human) | IC50 | 14.4000 | 1 | 1 |
| NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial | Bos taurus (cattle) | IC50 | 0.0051 | 1 | 1 |
| NADH-ubiquinone oxidoreductase chain 1 | Bos taurus (cattle) | IC50 | 0.0150 | 2 | 2 |
| nuclear receptor corepressor 2 isoform 2 | Homo sapiens (human) | IC50 | 39.8410 | 1 | 1 |
| P2X purinoceptor 3 | Homo sapiens (human) | IC50 | 0.7550 | 1 | 1 |
| Pancreatic triacylglycerol lipase | Sus scrofa (pig) | IC50 | 500.0000 | 1 | 1 |
| peroxisome proliferator-activated receptor gamma isoform 2 | Homo sapiens (human) | IC50 | 39.8410 | 1 | 1 |
| photoreceptor-specific nuclear receptor | Homo sapiens (human) | IC50 | 39.8410 | 1 | 1 |
| Polyphenol oxidase 2 | Agaricus bisporus | IC50 | 0.4000 | 5 | 5 |
| Polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | Ki | 9.0000 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Homo sapiens (human) | Ki | 8.0000 | 1 | 1 |
| procathepsin L isoform 1 preproprotein | Homo sapiens (human) | IC50 | 25.1129 | 2 | 2 |
| Prolyl 4-hydroxylase subunit alpha-1 | Gallus gallus (chicken) | Ki | 20,000.0000 | 1 | 1 |
| Renin | Homo sapiens (human) | IC50 | 0.9800 | 1 | 1 |
| Sodium channel protein type 1 subunit alpha | Homo sapiens (human) | IC50 | 0.0023 | 1 | 1 |
| Sodium channel protein type 10 subunit alpha | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Sodium channel protein type 11 subunit alpha | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Sodium channel protein type 2 subunit alpha | Homo sapiens (human) | IC50 | 0.0010 | 1 | 1 |
| Sodium channel protein type 3 subunit alpha | Homo sapiens (human) | IC50 | 0.0130 | 1 | 1 |
| Sodium channel protein type 4 subunit alpha | Homo sapiens (human) | IC50 | 0.0176 | 2 | 3 |
| Sodium channel protein type 5 subunit alpha | Homo sapiens (human) | IC50 | 0.2100 | 1 | 1 |
| Sodium channel protein type 7 subunit alpha | Homo sapiens (human) | IC50 | 0.4100 | 1 | 1 |
| Sodium channel protein type 8 subunit alpha | Homo sapiens (human) | IC50 | 0.0011 | 1 | 1 |
| Sodium channel protein type 9 subunit alpha | Homo sapiens (human) | IC50 | 0.5180 | 3 | 3 |
| Thermolysin | Bacillus thermoproteolyticus | IC50 | 71.1000 | 1 | 1 |
| Transcription factor 4 | Homo sapiens (human) | IC50 | 0.8000 | 1 | 1 |
| Transcription factor 7-like 2 | Homo sapiens (human) | Ki | 46.4167 | 6 | 6 |
| tyrosine-protein phosphatase non-receptor type 22 isoform 1 | Homo sapiens (human) | IC50 | 1.2950 | 2 | 2 |
| tyrosine-protein phosphatase non-receptor type 7 isoform 2 | Homo sapiens (human) | IC50 | 1.2400 | 1 | 1 |
| V-type proton ATPase subunit S1 | Homo sapiens (human) | IC50 | 0.1000 | 1 | 1 |
| Vacuolar proton pump subunit B | Gallus gallus (chicken) | IC50 | 0.0300 | 1 | 1 |