Page last updated: 2024-11-12

ceramide 3

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

N-oleoylphytosphingosine : A phytoceramide in which the N-acyl group is specified as oleoyl (9Z-octadecenoyl). [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID Source	ID
PubMed CID	57378373
CHEBI ID	85204
MeSH ID	M0070056

Synonyms (37)

Synonym
ceramide iii
ceramide gl(3)
100403-19-8
4370df050b ,
unii-4370df050b
ceramide 3
einecs 309-560-3
burkitt's lymphoma associated glycolipid antigen
n-octadecanoylphytosphingosine
ATGQXSBKTQANOH-UWVGARPKSA-N
n-oleoyl-phytosphingosine
phcer c18:1(n-9)
n-oleoylphytosphingosine
n-oloeoyl-4-hydroxysphinganine
(9z)-n-[(2s,3s,4r)-1,3,4-trihydroxyoctadecan-2-yl]octadec-9-enamide
n-(9z-octadecenoyl)-(4r)-hydroxysphinganine
cer(t18:0/18:1n-9)
n-(9z-octadecenoyl)phytosphingosine
CHEBI:85204
ceramide iiib
n-oleoyl phytosphingosine
ceramide np [inci]
cytomide iiib
cytomide iiia
ceramide 3 (retired ) [inci]
octadecanamide, n-(1,3,4-trihydroxy-2-octadecyl)-
ceramide np
Q27158397
n-(9z-octadecenoyl)-4-hydroxysphinganine
DB14111
178436-06-1
n-((2s,3s,4r)-1,3,4-trihydroxyoctadecan-2-yl)oleamide
ceramides mixture
ceramide 3b
DTXSID201319096
9-octadecenamide, n-[(1s,2s,3r)-2,3-dihydroxy-1-(hydroxymethyl)heptadecyl]-, (9z)-
AKOS040732785

Research Excerpts

Toxicity

Excerpt	Reference	Relevance
" We anticipate that face cream would be safe up to a ceramide 3 concentration of 3% (MOS = 149)."	( Safety and risk assessment of ceramide 3 in cosmetic products. Choi, SM; Lee, BM, 2015)	0.42

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

Class	Description
N-acylphytosphingosine	A ceramide that is phytosphingosine having a fatty acyl group attached to the nitrogen.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (15)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	3 (20.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	11 (73.33)	29.6817
2010's	1 (6.67)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	3 (20.00%)	5.53%
Reviews	1 (6.67%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	11 (73.33%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
palmitic acid Palmitic Acid: A common saturated fatty acid found in fats and waxes including olive oil, palm oil, and body lipids.. hexadecanoic acid : A straight-chain, sixteen-carbon, saturated long-chain fatty acid.	3.8	2	1	long-chain fatty acid; straight-chain saturated fatty acid	algal metabolite; Daphnia magna metabolite; EC 1.1.1.189 (prostaglandin-E2 9-reductase) inhibitor; plant metabolite
stearic acid octadecanoic acid : A C18 straight-chain saturated fatty acid component of many animal and vegetable lipids. As well as in the diet, it is used in hardening soaps, softening plastics and in making cosmetics, candles and plastics.	2	1	0	long-chain fatty acid; saturated fatty acid; straight-chain saturated fatty acid	algal metabolite; Daphnia magna metabolite; human metabolite; plant metabolite
deuterium Deuterium: The stable isotope of hydrogen. It has one neutron and one proton in the nucleus.	2.01	1	0	dihydrogen
laurocapram laurocapram: enhances percutaneous absorption of different chemicals; structure given in first source	2	1	0
phytosphingosine phytosphingosine: differ with an additional hydroxyl at C-4 & no double bond between C-4 & C-5	3.41	1	1	amino alcohol; sphingoid; triol	mouse metabolite; Saccharomyces cerevisiae metabolite
oleic acid Oleic Acid: An unsaturated fatty acid that is the most widely distributed and abundant fatty acid in nature. It is used commercially in the preparation of oleates and lotions, and as a pharmaceutical solvent. (Stedman, 26th ed). oleic acid : An octadec-9-enoic acid in which the double bond at C-9 has Z (cis) stereochemistry.	3.39	1	1	octadec-9-enoic acid	antioxidant; Daphnia galeata metabolite; EC 3.1.1.1 (carboxylesterase) inhibitor; Escherichia coli metabolite; mouse metabolite; plant metabolite; solvent
sodium dodecyl sulfate Sodium Dodecyl Sulfate: An anionic surfactant, usually a mixture of sodium alkyl sulfates, mainly the lauryl; lowers surface tension of aqueous solutions; used as fat emulsifier, wetting agent, detergent in cosmetics, pharmaceuticals and toothpastes; also as research tool in protein biochemistry.. sodium dodecyl sulfate : An organic sodium salt that is the sodium salt of dodecyl hydrogen sulfate.	4.09	3	1	organic sodium salt	detergent; protein denaturant
sphingosine sphing-4-enine : A sphingenine in which the C=C double bond is located at the 4-position.. sphingenine : A 2-aminooctadecene-1,3-diol having (2S,3R)-configuration.. sphingoid : Sphinganine, its homologs and stereoisomers, and the hydroxy and unsaturated derivatives of these compounds.. 2-aminooctadec-4-ene-1,3-diol : A 2-aminooctadecene-1,3-diol having its double bond at position 4.	3.41	1	1	sphing-4-enine	human metabolite; mouse metabolite
forssman glycolipid Forssman glycolipid: structure	1.95	1	0

Condition	Relationship Strength	Studies	Trials
Dermatitis, Irritant A non-allergic contact dermatitis caused by prolonged exposure to irritants and not explained by delayed hypersensitivity mechanisms.	4.65	3	2
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	2.04	1	0
Eczema, Atopic [description not available]	3.8	2	1
Dermatitis, Atopic A chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. In infants it is known as infantile eczema.	3.8	2	1
African Lymphoma [description not available]	2.37	2	0
Burkitt Lymphoma A form of undifferentiated malignant LYMPHOMA usually found in central Africa, but also reported in other parts of the world. It is commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass. B-cell antigens are expressed on the immature cells that make up the tumor in virtually all cases of Burkitt lymphoma. The Epstein-Barr virus (HERPESVIRUS 4, HUMAN) has been isolated from Burkitt lymphoma cases in Africa and it is implicated as the causative agent in these cases; however, most non-African cases are EBV-negative.	2.37	2	0
Allergic Contact Dermatitis [description not available]	3.39	1	1
Dermatitis Any inflammation of the skin.	3.39	1	1
Dermatitis, Allergic Contact A contact dermatitis due to allergic sensitization to various substances. These substances subsequently produce inflammatory reactions in the skin of those who have acquired hypersensitivity to them as a result of prior exposure.	3.39	1	1

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