| Flora | Rank | Flora Definition | Family | Family Definition |
|---|---|---|---|---|
| Centella | genus | A plant of the family APIACEAE which is the source of asiatic acid and asiaticoside. Centella asiatica (L.) Urb. = Hydrocotyle asiatica L. is known for effect on peripheral circulation.[MeSH] | Apiaceae | A large plant family in the order Apiales, also known as Umbelliferae. Most are aromatic herbs with alternate, feather-divided leaves that are sheathed at the base. The flowers often form a conspicuous flat-topped umbel. Each small individual flower is usually bisexual, with five sepals, five petals, and an enlarged disk at the base of the style. The fruits are ridged and are composed of two parts that split open at maturity.[MeSH] |
| Centella asiatica | species | [no description available] | Apiaceae | A large plant family in the order Apiales, also known as Umbelliferae. Most are aromatic herbs with alternate, feather-divided leaves that are sheathed at the base. The flowers often form a conspicuous flat-topped umbel. Each small individual flower is usually bisexual, with five sepals, five petals, and an enlarged disk at the base of the style. The fruits are ridged and are composed of two parts that split open at maturity.[MeSH] |
| ID Source | ID |
|---|---|
| PubMed CID | 24825675 |
| CHEMBL ID | 4787233 |
| CHEBI ID | 66651 |
| MeSH ID | M0246430 |
| Synonym |
|---|
| bdbm23212 |
| ursane triterpene, 22 |
| madecassoside , |
| asiaticoside a |
| 34540-22-2 |
| cq2f5o6yiy , |
| unii-cq2f5o6yiy |
| o-6-deoxy-alpha-l-mannopyranosyl-(1.4)-o-beta-d-glucopyranosyl-(1.6)-beta-d-glucopyranosyl (2alpha,3beta,4alpha,6beta)-2,3,6,23-tetrahydroxyurs-12-en-28-oate |
| redermic |
| einecs 252-076-1 |
| CHEBI:66651 , |
| o-6-deoxy-alpha-l-mannopyranosyl-(1->4)-o-beta-d-glucopyranosyl-(1->6)-beta-d-glucopyranosyl(2alpha,3beta,4alpha,6beta)-2,3,6,23-tetrahydroxyurs-12-en-28-oate |
| 6-deoxy-alpha-l-mannopyranosyl-(1->4)-beta-d-glucopyranosyl-(1->6)-1-o-[(2alpha,3beta,6beta)-2,3,6,23-tetrahydroxy-28-oxours-12-en-28-yl]-beta-d-glucopyranose |
| urs-12-en-28-oic acid, 2,3,6,23-tetrahydroxy-, o-6-deoxy-alpha-l-mannopyranosyl-(1-->4)-o-beta-d-glucopyranosyl-(1-->6)-beta-d-glucopyranosyl ester, (2alpha,3beta,4alpha,6beta)- |
| madecassoside [who-dd] |
| madecassoside (constituent of centella asiatica) [dsc] |
| madecassoside [inci] |
| AKOS037514732 |
| DB15532 |
| CHEMBL4787233 |
| [(2s,3r,4s,5s,6r)-6-[[(2r,3r,4r,5s,6r)-3,4-dihydroxy-6-(hydroxymethyl)-5-[(2s,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxymethyl]-3,4,5-trihydroxyoxan-2-yl] (1s,2r,4as,6ar,6as,6br,8r,8ar,9r,10r,11r,12ar,14bs)-8,10,11-trihydroxy-9-(hydr |
| DTXSID40956057 |
| careme madecassoside cica derma repair control treatment |
| 6-deoxy-alpha-l-mannopyranosyl-(1->4)-beta-d-glucopyranosyl-(1->6)-1-o-((2alpha,3beta,6beta)-2,3,6,23-tetrahydroxy-28-oxours-12-en-28-yl)-beta-d-glucopyranose |
Madecassoside (MAD) is a triterpenoid constituent of Centella asiatica (L.) Urb., an ethnomedical tropical plant. extracts of which were shown to reduce blood glucose in experimental diabetes.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Madecassoside (MA) has shown potential for the treatment of neuroinflammation." | ( Intravoxel Incoherent Motion Imaging Study of Madecassoside in Improving Lipopolysaccharide-Induced Cognitive Impairment in Rats. Dong, J; Fang, L; Guan, X; Li, G; Li, T; Liang, M; Liu, S; Zhou, Q, 2020) | 1.54 |
| Excerpt | Reference | Relevance |
|---|---|---|
| "Madecassoside was shown to increase the number of Treg cells and promote the expression of Foxp3 and IL-10 in rat ileum rather than duodenum and jejunum, as detected using the immunohistochemistry assay and quantitative PCR assay, respectively." | ( Regulation of gut microbiota substantially contributes to the induction of intestinal Treg cells and consequent anti-arthritis effect of madecassoside. Chen, L; Dai, Y; Lian, X; Qiao, S; Wei, Z; Xia, Y; Yue, M; Zhang, Q, 2020) | 1.48 |
Madecassoside treatment decreased the concentrations of sIgA in small intestine content and IFN-γ in small intestinal tissue. It also downregulated the ratios of CD4+/CD8+ in the epithelium and laminar propria. Treatment was found to improve locomotor dysfunction and to protect dopaminergic neuron.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Madecassoside treatment decreased the concentrations of sIgA in small intestine content and IFN-γ in small intestinal tissue, downregulated the ratios of CD4+/CD8+ in the epithelium and laminar propria and decreased the relative expressions of CD80, CD86, IL-6 and IL-12 mRNA, while upregulated the relative expression of Foxp3 mRNA in the small intestine." | ( [Effect of Madecassoside on Intestinal Mucosal Immunity in Collagen-Induced Arthritis Rats]. Dai, Y; Dou, YN; Wang, T; Wei, ZF; Xia, YF, 2015) | 1.53 |
| "Madecassoside treatment can downregulate the intestinal mucosal immune response and benefit for the induction and maintenance of intestinal immune tolerance." | ( [Effect of Madecassoside on Intestinal Mucosal Immunity in Collagen-Induced Arthritis Rats]. Dai, Y; Dou, YN; Wang, T; Wei, ZF; Xia, YF, 2015) | 1.53 |
| "Treatment with madecassoside was found to improve locomotor dysfunction and to protect dopaminergic neuron by antagonizing MPTP induced neurotoxicity." | ( Neuroprotective effects of madecassoside in early stage of Parkinson's disease induced by MPTP in rats. Li, LF; Ma, SP; Qu, R; Xu, CL; Zhang, J, 2013) | 1.03 |
| "Treatment with madecassoside (3.2, 1.6 and 0.8 mg x kg(-1)) i.v." | ( [Protective effect of madecassoside against reperfusion injury after regional ischemia in rabbit heart in vivo]. Bian, GX; Li, GG; Lü, QJ; Ren, JP; Wen, LQ; Zhang, M, 2007) | 0.99 |
| Excerpt | Reference | Relevance |
|---|---|---|
| " Doxorubicin (DOX), a common chemotherapeutic drug, has been reported to induce numerous toxic side effects including renal-toxicity." | ( Protective effects of madecassoside against Doxorubicin induced nephrotoxicity in vivo and in vitro. Ding, X; Qin, Z; Su, Z; Ye, J, 2015) | 0.73 |
| "Nephrotoxicity is a major side effect of cisplatin." | ( Madecassoside ameliorates cisplatin-induced nephrotoxicity by inhibiting activation of the mitogen activated protein kinase pathway. Li, S; Qin, J; Yu, X; Yuan, H; Zhao, Y, 2023) | 2.35 |
The pharmacokinetic comparison of madecassoside and asiaticoside was performed in rats following intravenous and oral administration of ECa 233.
| Excerpt | Reference | Relevance |
|---|---|---|
| " The bioavailability of 29 was significantly improved in comparison with its aglycon." | ( Synthesis and anti-inflammatory activity of saponin derivatives of δ-oleanolic acid. Chen, C; Cheng, K; Dai, L; Hu, K; Li, H; Liu, L; Sun, H; Wen, X; Xu, Q; Yuan, H, 2021) | 0.62 |
| " Centell-S increased oral bioavailability of major triterpenoid glycosides and can be further developed into a phytopharmaceutical product." | ( Increase water solubility of Centella asiatica extract by indigenous bioenhancers could improve oral bioavailability and disposition kinetics of triterpenoid glycosides in beagle dogs. Boonyarattanasoonthorn, T; Buranasudja, V; Khemawoot, P; Kijtawornrat, A; Nuengchamnong, N; Songvut, P, 2022) | 0.72 |
| Role | Description |
|---|---|
| antioxidant | A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides. |
| anti-inflammatory agent | Any compound that has anti-inflammatory effects. |
| antirheumatic drug | A drug used to treat rheumatoid arthritis. |
| vulnerary | A drug used in treating and healing of wounds. |
| plant metabolite | Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Class | Description |
|---|---|
| pentacyclic triterpenoid | |
| trisaccharide derivative | An oligosaccharide derivative that is formally obtained from a trisaccharide. |
| carboxylic ester | An ester of a carboxylic acid, R(1)C(=O)OR(2), where R(1) = H or organyl and R(2) = organyl. |
| triterpenoid saponin | A terpene glycoside in which the terpene moiety is a triterpenoid. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1728066 | Activation of AMPK in human Huh-7 cells assessed as increase in AMPK phosphorylation at Thr172 residue at 10 uM measured after 12 hrs by Western blot analysis | 2021 | European journal of medicinal chemistry, Jan-01, Volume: 209 | Synthesis and anti-inflammatory activity of saponin derivatives of δ-oleanolic acid. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (1.19) | 18.7374 |
| 1990's | 1 (1.19) | 18.2507 |
| 2000's | 13 (15.48) | 29.6817 |
| 2010's | 45 (53.57) | 24.3611 |
| 2020's | 24 (28.57) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.
| This Compound (49.52) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 2 (2.35%) | 5.53% |
| Reviews | 4 (4.71%) | 6.00% |
| Case Studies | 1 (1.18%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 78 (91.76%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||