2-Methylresorcinol, also known as 4-methylbenzene-1,3-diol, is a phenolic compound with a methyl group at the 2-position of the resorcinol ring. It is a colorless solid that is found in various natural sources, including plants like Equisetum arvense (horsetail) and fruits like oranges.
The compound exhibits antioxidant and anti-inflammatory properties, making it a potential therapeutic agent. It has been investigated for its potential in treating conditions such as inflammation, oxidative stress, and cancer.
2-Methylresorcinol has also been studied for its antimicrobial activity against bacteria and fungi. Its synthesis involves various methods, including the methylation of resorcinol and the reduction of 2-methyl-3,5-dinitrophenol.
The importance of 2-methylresorcinol lies in its potential pharmacological applications, its occurrence in nature, and its potential role in various biological processes. Further research is ongoing to explore its therapeutic potential and understand its role in human health and disease.'
| ID Source | ID |
|---|---|
| PubMed CID | 11843 |
| CHEMBL ID | 2332773 |
| SCHEMBL ID | 33721 |
| MeSH ID | M0140816 |
| Synonym |
|---|
| 32w7044a3t , |
| ec 210-155-8 |
| unii-32w7044a3t |
| 4-06-00-05877 (beilstein handbook reference) |
| 2-methyl-benzene-1,3-diol |
| 2-methylresorcin |
| resorcinol, 2-methyl- |
| 608-25-3 |
| nsc-66524 |
| toluene-2,6-diol |
| 1,3-dihydroxy-2-methylbenzene |
| nsc66524 |
| 2,6-dihydroxytoluene |
| 2-methylresorcinol |
| 2-methylbenzene-1,3-diol |
| inchi=1/c7h8o2/c1-5-6(8)3-2-4-7(5)9/h2-4,8-9h,1h |
| 1,3-benzenediol, 2-methyl- |
| 2-methyl-1,3-dihydroxybenzene |
| nsc 66524 |
| einecs 210-155-8 |
| brn 2042177 |
| ai3-61050 |
| 2-methylresorcinol, technical grade, 90% |
| 2-methylresorcinol, 98% |
| 2-methyl-1,3-benzenediol |
| M-4340 |
| AC-11239 |
| FT-0654680 |
| M0425 |
| M1109 |
| AKOS000121503 |
| A832909 |
| NCGC00255355-01 |
| dtxcid005571 |
| tox21_301973 |
| dtxsid0025571 , |
| cas-608-25-3 |
| 1,3-benzenediol, methyl- |
| FT-0613080 |
| rodol mrs |
| methyl-1,3-benzenediol, 2- |
| oristar mr |
| 2-methylresorcinol [inci] |
| CHEMBL2332773 , |
| SCHEMBL33721 |
| EG-0038 |
| 3-hydroxy-2-methylphenol |
| methyl resorcinol |
| 2-methyl-resorcinol |
| STR04303 |
| 2-methyl-1,3-benzenediol # |
| mfcd00002271 |
| F0001-1592 |
| 2-methylresorcinol, technical, >=90% (gc) |
| bdbm50187503 |
| CS-W013532 |
| 2,6-dihydroxy-1-methylbenzene |
| Q9549707 |
| AMY19648 |
| STL183298 |
| D70597 |
| 1251900-91-0 |
| 2,6-dihydroxy-toluene |
| EN300-16605 |
| Z56347205 |
| Product Category | Products |
|---|---|
| Beauty & Personal Care | 13 |
| Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 14.0061 | 0.0007 | 14.5928 | 83.7951 | AID1259369; AID1259392 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 14.0061 | 0.0006 | 57.9133 | 22,387.1992 | AID1259377 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 17.7828 | 0.0002 | 29.3054 | 16,493.5996 | AID743078 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 59.1614 | 0.0007 | 23.0674 | 1,258.9301 | AID743085; AID743122 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 0.9916 | 0.0023 | 19.5956 | 74.0614 | AID651631 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Polyphenol oxidase 2 | Agaricus bisporus | IC50 (µMol) | 1,066.0000 | 0.0340 | 3.9871 | 10.0000 | AID1312207; AID1312208 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID733605 | Inactivation of tyrosinase (unknown origin) assessed as initial rate of oxygen utilization using 4-methylcatechol substrate at 850 uM equimolar concentrations resorcinol by spectrophotometry | 2013 | Bioorganic & medicinal chemistry, Mar-01, Volume: 21, Issue:5 | Mechanistic studies of the inactivation of tyrosinase by resorcinol. |
| AID733601 | Inactivation of tyrosinase (unknown origin) assessed as total oxygen uptake using 4-methylcatechol substrate at 850 uM equimolar concentrations resorcinol by spectrophotometry | 2013 | Bioorganic & medicinal chemistry, Mar-01, Volume: 21, Issue:5 | Mechanistic studies of the inactivation of tyrosinase by resorcinol. |
| AID733603 | Inactivation of tyrosinase (unknown origin) assessed as initial rate of oxygen utilization at absorbance 400 nm using 4-methylcatechol substrate at 850 uM equimolar concentrations resorcinol by spectrophotometry | 2013 | Bioorganic & medicinal chemistry, Mar-01, Volume: 21, Issue:5 | Mechanistic studies of the inactivation of tyrosinase by resorcinol. |
| AID1312208 | Inhibition of mushroom tyrosinase using L-dopa as substrate assessed as diphenolase activity by spectrophotometric analysis | 2016 | Bioorganic & medicinal chemistry, 09-15, Volume: 24, Issue:18 | Characterization of the action of tyrosinase on resorcinols. |
| AID1312213 | Substrate activity at mushroom tyrosinase assessed as Km for monophenolase activity in presence H2O2 by spectrophotometry based Michaelis-Menten plot analysis | 2016 | Bioorganic & medicinal chemistry, 09-15, Volume: 24, Issue:18 | Characterization of the action of tyrosinase on resorcinols. |
| AID733599 | Inactivation of tyrosinase (unknown origin) assessed as decay half-life using 4-methylcatechol substrate at 850 uM equimolar concentrations resorcinol by spectrophotometry | 2013 | Bioorganic & medicinal chemistry, Mar-01, Volume: 21, Issue:5 | Mechanistic studies of the inactivation of tyrosinase by resorcinol. |
| AID1312215 | Substrate activity at mushroom tyrosinase assessed as Kcat/Km ratio for monophenolase activity in presence H2O2 by spectrophotometry based Michaelis-Menten plot analysis | 2016 | Bioorganic & medicinal chemistry, 09-15, Volume: 24, Issue:18 | Characterization of the action of tyrosinase on resorcinols. |
| AID1312209 | Substrate activity at mushroom tyrosinase using TBC as substrate assessed as increase in TBC oxidation at 0.05 to 0.50 mM by spectrophotometric analysis | 2016 | Bioorganic & medicinal chemistry, 09-15, Volume: 24, Issue:18 | Characterization of the action of tyrosinase on resorcinols. |
| AID1312214 | Substrate activity at mushroom tyrosinase assessed as Kcat for monophenolase activity in presence H2O2 by spectrophotometry based Michaelis-Menten plot analysis | 2016 | Bioorganic & medicinal chemistry, 09-15, Volume: 24, Issue:18 | Characterization of the action of tyrosinase on resorcinols. |
| AID1312210 | Activity of mushroom tyrosinase using TBC as substrate assessed as accumulation of p-quinone in presence of H2O2 spectrophotometric analysis | 2016 | Bioorganic & medicinal chemistry, 09-15, Volume: 24, Issue:18 | Characterization of the action of tyrosinase on resorcinols. |
| AID1312207 | Inhibition of mushroom tyrosinase using L-tyrosine as substrate assessed as monophenolase activity by spectrophotometric analysis | 2016 | Bioorganic & medicinal chemistry, 09-15, Volume: 24, Issue:18 | Characterization of the action of tyrosinase on resorcinols. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 2 (18.18) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 7 (63.64) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.
| This Compound (43.00) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 13 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||