An agent that destroy spermatozoa in the male genitalia and block spermatogenesis.
ChEBI ID: 145047
| Member | Definition | Class |
|---|---|---|
| gamendazole | A member of the class of indazoles that is 3-(indazol-3-yl}prop-2-enoic acid carrying additional 2,4-dichlorobenzyl and trifluoromethyl substituents at positions 1 and 6 respectively. An orally active antispermatogenic compound with antifertility effects that is a potential male contraceptive drug. | gamendazole |
| lonidamine | A member of the class of indazoles that is 1H-indazole that is substituted at positions 1 and 3 by 2,4-dichlorobenzyl and carboxy groups, respectively. | lonidamine |
| molinate | A member of the class of azepanes that is azepane in which the nitrogen is substituted by an (ethylsulfanyl)carbonyl group, -C(=O)SEt. A thiocarbamate herbicide not approved for use in the U.S. or European Union, it is used control grass weeds in rice paddies. | molinate |
| solasodine | An oxaspiro compound and steroid alkaloid sapogenin with formula C27H43NO2 found in the Solanum (nightshade) family. It is used as a precursor in the synthesis of complex steroidal compounds such as contraceptive pills. | solasodine |
| triptolide | Triptolide |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 105 (6.68) | 18.7374 |
| 1990's | 154 (9.79) | 18.2507 |
| 2000's | 322 (20.47) | 29.6817 |
| 2010's | 720 (45.77) | 24.3611 |
| 2020's | 272 (17.29) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 61 (3.64%) | 5.53% |
| Reviews | 110 (6.56%) | 6.00% |
| Case Studies | 6 (0.36%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 1,500 (89.45%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| activating transcription factor 6 | Homo sapiens (human) | Potency | 38.6384 | 1 | 1 |
| Alpha-synuclein | Homo sapiens (human) | Potency | 29.0929 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 21.5721 | 5 | 6 |
| arylsulfatase A | Homo sapiens (human) | Potency | 1.0691 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 68.1016 | 1 | 1 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 0.5623 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 8.9515 | 1 | 2 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 2.5119 | 2 | 2 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 38.9018 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 15.3309 | 7 | 9 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 39.3587 | 2 | 3 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 68.1016 | 5 | 6 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 16.9308 | 1 | 2 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 0.0037 | 1 | 1 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 24.3792 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 2.5119 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 2.5119 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 2.5119 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 2.5119 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 2.5119 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 2.5119 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 2.5119 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 2.5119 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 2.5119 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 2.5119 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 2.5119 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 2.5119 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 2.5119 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 2.5119 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 2.5119 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 2.5119 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 0.0073 | 1 | 1 |
| GLS protein | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 43.3530 | 2 | 2 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 2.1536 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 39.8107 | 1 | 3 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 15.8489 | 2 | 2 |
| Interferon beta | Homo sapiens (human) | Potency | 0.0829 | 1 | 3 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 0.0891 | 1 | 1 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 33.8078 | 1 | 1 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 3.1623 | 1 | 1 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 35.4813 | 1 | 1 |
| NPC intracellular cholesterol transporter 1 precursor | Homo sapiens (human) | Potency | 0.0891 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 46.5367 | 3 | 6 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 16.3601 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 10.7790 | 2 | 3 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 26.5303 | 1 | 1 |
| P53 | Homo sapiens (human) | Potency | 14.1254 | 1 | 1 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 95.2834 | 1 | 1 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 14.7286 | 2 | 3 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 7.6660 | 1 | 2 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 14.1254 | 1 | 1 |
| PPM1D protein | Homo sapiens (human) | Potency | 0.0829 | 1 | 2 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 60.6957 | 1 | 1 |
| progesterone receptor | Homo sapiens (human) | Potency | 21.5503 | 1 | 2 |
| Rap guanine nucleotide exchange factor 4 | Homo sapiens (human) | Potency | 6.3096 | 1 | 1 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 1.0000 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 40.4459 | 2 | 3 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 14.4852 | 2 | 5 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 17.2853 | 2 | 3 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 17.2853 | 2 | 3 |
| TDP1 protein | Homo sapiens (human) | Potency | 1.1795 | 2 | 3 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 0.4467 | 1 | 1 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 48.2123 | 2 | 2 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 39.8107 | 2 | 2 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 48.6429 | 1 | 1 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 11.8823 | 1 | 1 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 2.1536 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| dCTP pyrophosphatase 1 | Homo sapiens (human) | IC50 | 30.9000 | 4 | 4 |
| dCTP pyrophosphatase 1 | Homo sapiens (human) | Ki | 168.0000 | 1 | 1 |
| M17 leucyl aminopeptidase | Plasmodium falciparum 3D7 | IC50 | 7.3700 | 1 | 1 |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | IC50 | 0.0400 | 1 | 1 |
| Proteinase-activated receptor 2 | Homo sapiens (human) | IC50 | 0.0185 | 2 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| calcineurin A1, putative | Candida dubliniensis CD36 | EC50 | 180.0000 | 1 | 1 |
| heat shock protein 90 | Candida albicans | EC50 | 120.0330 | 3 | 4 |