epidermal growth factor receptor antagonist

An antagonist at the epidermal growth factor receptor.

ChEBI ID: 74440

Members (13)

Member	Definition	Class
aee 788	A 6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-N-(1-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine which adopts an R-configuration. It is a potent inhibitor of human EGFR, VEGFR and HER2 receptor tyrosine kinases and exhibits anticancer and antiangiogenic activity.	AEE788
azd 8931	A member of the class of quinazolines that is 4-amino-7-methoxyquinazoline in which the amino group has been substituted by a 3-chloro-2-fluorophenyl group and in which position 6 of the quinoline ring has been substituted by a {1-[2-(methylamino)-2-oxoethyl]piperidin-4-yl}oxy group. Sapitinib is a dual tyrosine kinase inhibitor (TKI) of epithelial growth factor receptors (EGFR) HER2 and HER3.	sapitinib
cl 387785	A member of the class of quinazolines that is 4,6-diaminoquinazoine in which the one of the hydrogens attached to the amino group at position 4 has been replaced by a m-bromophenyl group while one of the hydrogens attached to the amino group at position 6 has been replaced by a but-2-ynoyl group.	N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}but-2-ynamide
erlotinib	A quinazoline compound having a (3-ethynylphenyl)amino group at the 4-position and two 2-methoxyethoxy groups at the 6- and 7-positions.	erlotinib
gefitinib	A member of the class of quinazolines that is quinazoline which is substituted by a (3-chloro-4-fluorophenyl)nitrilo group, 3-(morpholin-4-yl)propoxy group and a methoxy group at positions 4,6 and 7, respectively. An EGFR kinase inhibitor used for the treatment of non-small cell lung cancer.	gefitinib
osimertinib	A member of the class of aminopyrimidines that is 4-(1-methylindol-3-yl)pyrimidin-2-amine in which one of the amino hydrogens is replaced by a 2-methoxy-4-[2-(dimethylamino)ethyl](methyl)amino-5-acrylamidophenyl group. Used (as the mesylate salt) for treatment of EGFR T790M mutation positive non-small cell lung cancer.	osimertinib
pd 153035	A member of the class of quinazolines carrying a 3-bromophenylamino substituent at position 4 and two methoxy substituents at positions 6 and 7.	PD-153035
pd168393	A member of the class of quinazolines carrying bromoanilino and acrylamido substituents at positions 4 and 6 respectively.	PD 168393
pf 00299804	A member of the class of quinazolines that is 7-methoxyquinazoline-4,6-diamine in which the amino group at position 4 is substituted by a 3-chloro-4-fluorophenyl group and the amino group at position 6 is substituted by an (E)-4-(piperidin-1-yl)but-2-enoyl group.	dacomitinib
poziotinib	A member of the class of quinazolines that is quinazoline substituted by (3,4-dichloro-2-fluorophenyl)amino, [1-(prop-2-enoyl)piperidin-4-yl]oxy, and methoxy groups at positions 4, 6, and 7, respectively. It is a potent and irreversible tyrosine kinase inhibitor targeting EGFR and HER2 with exon 20 insertion mutations.	poziotinib
rtki cpd	A member of the class of quinazolines that is quinazoline substituted by methoxy groups at positions 6 and 7 and a (3-chlorophenyl)nitrilo group at position 4. It acts as an epidermal growth factor receptor antagonist.	tyrphostin AG 1478
tyrphostin ag825	An organic sulfide that consists of 1,3-benzothiazole-2-thiol in which the hydrogen attached to the sulfur atom is replaced by a 5-[(1E)-3-amino-2-cyano-3-oxoprop-1-en-1-yl]-2-hydroxy-3-methoxybenzyl group. It acts as an epidermal growth factor receptor antagonist.	tyrphostin AG 825
zm 252868	A hydrochloride obtained by combining PD-153035 with one equivalent of hydrochloric acid.	PD-153035 hydrochloride

Research

Studies (6,961)

Timeframe	Studies, Drugs with This Role(%)	All Drugs %
pre-1990	1 (0.01)	18.7374
1990's	43 (0.62)	18.2507
2000's	2,110 (30.31)	29.6817
2010's	3,312 (47.58)	24.3611
2020's	1,495 (21.48)	2.80

Study Types

Publication Type	Studies, Drugs with this Role (%)	All Drugs (%)
Trials	758 (10.08%)	5.53%
Reviews	902 (11.99%)	6.00%
Case Studies	752 (10.00%)	4.05%
Observational	43 (0.57%)	0.25%
Other	5,066 (67.36%)	84.16%

Protein Targets (669)

Potency Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	Homo sapiens (human)	Potency	35.6383	1	3
15-lipoxygenase, partial	Homo sapiens (human)	Potency	15.8489	1	1
67.9K protein	Vaccinia virus	Potency	20.2567	2	4
acetylcholinesterase	Homo sapiens (human)	Potency	36.7866	2	2
aldehyde dehydrogenase 1 family, member A1	Homo sapiens (human)	Potency	28.9516	1	6
alpha-galactosidase	Homo sapiens (human)	Potency	44.6684	1	1
AR protein	Homo sapiens (human)	Potency	15.1680	7	12
aryl hydrocarbon receptor	Homo sapiens (human)	Potency	6.6798	2	4
ATAD5 protein, partial	Homo sapiens (human)	Potency	17.1426	6	6
ATP-dependent phosphofructokinase	Trypanosoma brucei brucei TREU927	Potency	0.8492	1	1
Bloom syndrome protein isoform 1	Homo sapiens (human)	Potency	0.0282	2	2
caspase 7, apoptosis-related cysteine protease	Homo sapiens (human)	Potency	33.4915	1	1
caspase-3	Cricetulus griseus (Chinese hamster)	Potency	33.4915	1	1
caspase-3	Homo sapiens (human)	Potency	33.4915	1	1
Caspase-7	Cricetulus griseus (Chinese hamster)	Potency	33.4915	1	1
Cellular tumor antigen p53	Homo sapiens (human)	Potency	30.0474	1	2
cellular tumor antigen p53 isoform a	Homo sapiens (human)	Potency	28.3708	1	2
Chain A, 2-oxoglutarate Oxygenase	Homo sapiens (human)	Potency	24.9085	1	3
Chain A, Ferritin light chain	Equus caballus (horse)	Potency	25.6651	2	2
Chain A, HADH2 protein	Homo sapiens (human)	Potency	22.7496	2	3
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	Homo sapiens (human)	Potency	29.5262	1	2
Chain A, Putative fructose-1,6-bisphosphate aldolase	Giardia intestinalis	Potency	25.0594	1	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	Homo sapiens (human)	Potency	0.0009	1	1
Chain B, HADH2 protein	Homo sapiens (human)	Potency	22.7496	2	3
cytochrome P450 2C19 precursor	Homo sapiens (human)	Potency	2.5788	1	2
cytochrome P450 2C9 precursor	Homo sapiens (human)	Potency	0.3981	1	1
cytochrome P450 2C9, partial	Homo sapiens (human)	Potency	11.5493	1	5
cytochrome P450 2D6	Homo sapiens (human)	Potency	12.8239	1	7
cytochrome P450 2D6 isoform 1	Homo sapiens (human)	Potency	13.8826	1	3
cytochrome P450 3A4 isoform 1	Homo sapiens (human)	Potency	4.0518	2	6
cytochrome P450 family 3 subfamily A polypeptide 4	Homo sapiens (human)	Potency	9.0669	1	8
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	Homo sapiens (human)	Potency	9.6822	1	2
dual specificity protein kinase CLK4	Homo sapiens (human)	Potency	20.6665	1	1
dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 1	Homo sapiens (human)	Potency	18.4191	1	1
epidermal growth factor receptor isoform a precursor	Homo sapiens (human)	Potency	0.3369	3	6
estrogen nuclear receptor alpha	Homo sapiens (human)	Potency	20.6449	7	10
estrogen receptor 2 (ER beta)	Homo sapiens (human)	Potency	11.2764	2	3
estrogen-related nuclear receptor alpha	Homo sapiens (human)	Potency	12.5243	8	18
euchromatic histone-lysine N-methyltransferase 2	Homo sapiens (human)	Potency	13.3295	1	3
EWS/FLI fusion protein	Homo sapiens (human)	Potency	10.5643	4	23
farnesoid X nuclear receptor	Homo sapiens (human)	Potency	26.6011	1	1
flap endonuclease 1	Homo sapiens (human)	Potency	37.3016	1	2
Fumarate hydratase	Homo sapiens (human)	Potency	31.5236	1	4
G	Vesicular stomatitis virus	Potency	11.5493	1	5
GABA theta subunit	Rattus norvegicus (Norway rat)	Potency	4.0518	1	3
Gamma-aminobutyric acid receptor subunit alpha-1	Rattus norvegicus (Norway rat)	Potency	4.0518	1	3
Gamma-aminobutyric acid receptor subunit alpha-2	Rattus norvegicus (Norway rat)	Potency	4.0518	1	3
Gamma-aminobutyric acid receptor subunit alpha-3	Rattus norvegicus (Norway rat)	Potency	4.0518	1	3
Gamma-aminobutyric acid receptor subunit alpha-4	Rattus norvegicus (Norway rat)	Potency	4.0518	1	3
Gamma-aminobutyric acid receptor subunit alpha-5	Rattus norvegicus (Norway rat)	Potency	4.0518	1	3
Gamma-aminobutyric acid receptor subunit alpha-6	Rattus norvegicus (Norway rat)	Potency	4.0518	1	3
Gamma-aminobutyric acid receptor subunit beta-1	Rattus norvegicus (Norway rat)	Potency	4.0518	1	3
Gamma-aminobutyric acid receptor subunit beta-2	Rattus norvegicus (Norway rat)	Potency	4.0518	1	3
Gamma-aminobutyric acid receptor subunit beta-3	Rattus norvegicus (Norway rat)	Potency	4.0518	1	3
Gamma-aminobutyric acid receptor subunit delta	Rattus norvegicus (Norway rat)	Potency	4.0518	1	3
Gamma-aminobutyric acid receptor subunit epsilon	Rattus norvegicus (Norway rat)	Potency	4.0518	1	3
Gamma-aminobutyric acid receptor subunit gamma-1	Rattus norvegicus (Norway rat)	Potency	4.0518	1	3
Gamma-aminobutyric acid receptor subunit gamma-2	Rattus norvegicus (Norway rat)	Potency	4.0518	1	3
Gamma-aminobutyric acid receptor subunit gamma-3	Rattus norvegicus (Norway rat)	Potency	4.0518	1	3
Gamma-aminobutyric acid receptor subunit pi	Rattus norvegicus (Norway rat)	Potency	4.0518	1	3
geminin	Homo sapiens (human)	Potency	11.6407	3	4
GLI family zinc finger 3	Homo sapiens (human)	Potency	9.9312	2	6
glucocerebrosidase	Homo sapiens (human)	Potency	0.8913	1	1
glucocorticoid receptor [Homo sapiens]	Homo sapiens (human)	Potency	23.6719	2	2
Glutamate receptor 2	Rattus norvegicus (Norway rat)	Potency	23.2408	1	2
Histamine H2 receptor	Cavia porcellus (domestic guinea pig)	Potency	13.6706	2	9
histone acetyltransferase KAT2A isoform 1	Homo sapiens (human)	Potency	27.8710	1	5
HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)	Potency	11.5493	1	5
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	Homo sapiens (human)	Potency	15.8489	2	2
Inositol hexakisphosphate kinase 1	Homo sapiens (human)	Potency	11.5493	1	10
Inositol monophosphatase 1	Rattus norvegicus (Norway rat)	Potency	7.6237	1	2
Interferon beta	Homo sapiens (human)	Potency	14.6335	3	30
lamin isoform A-delta10	Homo sapiens (human)	Potency	8.4526	2	4
lethal factor (plasmid)	Bacillus anthracis str. A2012	Potency	6.9606	1	4
Microtubule-associated protein tau	Homo sapiens (human)	Potency	21.8974	2	9
mitogen-activated protein kinase 1	Homo sapiens (human)	Potency	3.4405	3	6
muscarinic acetylcholine receptor M1	Rattus norvegicus (Norway rat)	Potency	15.9541	2	2
NFKB1 protein, partial	Homo sapiens (human)	Potency	15.8489	2	2
nuclear factor erythroid 2-related factor 2 isoform 1	Homo sapiens (human)	Potency	2.9948	2	3
nuclear receptor ROR-gamma isoform 1	Mus musculus (house mouse)	Potency	10.7794	2	3
nuclear receptor subfamily 1, group I, member 3	Homo sapiens (human)	Potency	4.3752	3	7
peripheral myelin protein 22	Rattus norvegicus (Norway rat)	Potency	36.1254	1	1
peripheral myelin protein 22 isoform 1	Homo sapiens (human)	Potency	75.6863	1	1
phosphopantetheinyl transferase	Bacillus subtilis	Potency	56.2341	1	1
polyprotein	Zika virus	Potency	31.5236	1	4
Polyunsaturated fatty acid lipoxygenase ALOX15B	Homo sapiens (human)	Potency	20.3068	1	3
potassium voltage-gated channel subfamily H member 2 isoform d	Homo sapiens (human)	Potency	35.4813	1	1
PPM1D protein	Homo sapiens (human)	Potency	15.3935	1	16
pregnane X nuclear receptor	Homo sapiens (human)	Potency	13.5594	2	4
progesterone receptor	Homo sapiens (human)	Potency	27.3116	2	2
RAF proto-oncogene serine/threonine-protein kinase isoform b	Homo sapiens (human)	Potency	18.6807	1	3
RAR-related orphan receptor gamma	Mus musculus (house mouse)	Potency	8.7942	2	4
retinoic acid nuclear receptor alpha variant 1	Homo sapiens (human)	Potency	22.8506	3	3
retinoid X nuclear receptor alpha	Homo sapiens (human)	Potency	4.1818	2	4
serine/threonine-protein kinase mTOR isoform 1	Homo sapiens (human)	Potency	20.5045	1	1
SMAD family member 2	Homo sapiens (human)	Potency	10.7530	2	2
SMAD family member 3	Homo sapiens (human)	Potency	10.7530	2	2
Smad3	Homo sapiens (human)	Potency	10.0000	1	1
Spike glycoprotein	Severe acute respiratory syndrome-related coronavirus	Potency	9.4034	2	4
survival motor neuron protein isoform d	Homo sapiens (human)	Potency	39.8107	1	1
TDP1 protein	Homo sapiens (human)	Potency	18.1175	2	17
thioredoxin reductase	Rattus norvegicus (Norway rat)	Potency	0.3162	2	2
thyroid hormone receptor beta isoform 2	Rattus norvegicus (Norway rat)	Potency	16.1141	2	4
thyroid stimulating hormone receptor	Homo sapiens (human)	Potency	39.8107	2	2
tyrosine-protein kinase Yes	Homo sapiens (human)	Potency	0.8190	2	5
USP1 protein, partial	Homo sapiens (human)	Potency	43.9284	1	2
v-jun sarcoma virus 17 oncogene homolog (avian)	Homo sapiens (human)	Potency	7.8059	1	1
vitamin D (1,25- dihydroxyvitamin D3) receptor	Homo sapiens (human)	Potency	11.8823	1	1
vitamin D3 receptor isoform VDRA	Homo sapiens (human)	Potency	89.1251	1	1
Voltage-dependent calcium channel gamma-2 subunit	Mus musculus (house mouse)	Potency	23.2408	1	2

Inhibition Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
Adenosine receptor A1	Rattus norvegicus (Norway rat)	IC50	0.0063	1	1
ALK tyrosine kinase receptor	Homo sapiens (human)	IC50	0.1770	1	1
Alpha-1A adrenergic receptor	Sus scrofa (pig)	IC50	0.3000	1	1
ATP-binding cassette sub-family C member 3	Homo sapiens (human)	IC50	133.0000	1	1
ATP-dependent translocase ABCB1	Homo sapiens (human)	IC50	22.9850	2	2
Beta-secretase 1	Homo sapiens (human)	IC50	20.0000	1	1
Bile salt export pump	Homo sapiens (human)	IC50	10.6750	4	4
Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)	IC50	6.0830	8	10
Canalicular multispecific organic anion transporter 1	Homo sapiens (human)	IC50	71.5000	2	2
Casein kinase I isoform alpha	Homo sapiens (human)	IC50	50.0000	1	1
Corticosteroid 11-beta-dehydrogenase isozyme 1	Rattus norvegicus (Norway rat)	IC50	0.0300	1	1
Cruzipain	Trypanosoma cruzi	IC50	118.0000	2	2
Cyclin-dependent kinase 1	Homo sapiens (human)	IC50	50.2393	2	6
Cyclin-dependent kinase 2	Homo sapiens (human)	IC50	125.5700	2	2
Cyclin-G-associated kinase	Homo sapiens (human)	IC50	0.4070	2	4
Cytochrome P450 1A2	Homo sapiens (human)	IC50	5.0755	2	2
Cytochrome P450 2C19	Homo sapiens (human)	IC50	3.4127	3	3
Cytochrome P450 2C8	Homo sapiens (human)	IC50	0.1510	1	1
Cytochrome P450 2C9	Homo sapiens (human)	IC50	10.0000	1	1
Cytochrome P450 2D6	Homo sapiens (human)	IC50	10.0000	1	1
Cytochrome P450 2E1	Homo sapiens (human)	IC50	0.4600	1	1
Cytochrome P450 3A4	Homo sapiens (human)	IC50	5.0080	2	2
Cytochrome P450 3A4	Homo sapiens (human)	Ki	6.3000	1	3
Cytoplasmic tyrosine-protein kinase BMX	Homo sapiens (human)	IC50	0.5757	3	3
D(1A) dopamine receptor	Sus scrofa (pig)	IC50	0.3000	1	1
Dihydrofolate reductase	Homo sapiens (human)	IC50	0.2000	1	1
Dihydrofolate reductase	Mus musculus (house mouse)	IC50	0.2000	1	1
Dihydrofolate reductase	Pneumocystis carinii	IC50	0.2000	1	1
Dihydrofolate reductase	Rattus norvegicus (Norway rat)	IC50	0.2000	1	1
Dipeptidyl peptidase 1	Homo sapiens (human)	IC50	32.9000	1	1
DNA-dependent protein kinase catalytic subunit	Homo sapiens (human)	IC50	50.0000	1	1
Ephrin type-B receptor 2	Homo sapiens (human)	IC50	10.2000	1	1
Ephrin type-B receptor 4	Homo sapiens (human)	IC50	1.0000	1	1
Epidermal growth factor receptor	Homo sapiens (human)	GI50	0.6719	20	20
Epidermal growth factor receptor	Mus musculus (house mouse)	GI50	2.6000	1	1
Epidermal growth factor receptor	Homo sapiens (human)	IC50	2.6266	522	654
Epidermal growth factor receptor	Mus musculus (house mouse)	IC50	0.0905	2	2
Epidermal growth factor receptor	Homo sapiens (human)	Ki	0.0520	23	26
epidermal growth factor receptor isoform a precursor	Homo sapiens (human)	IC50	0.0025	1	2
Fatty-acid amide hydrolase 1	Rattus norvegicus (Norway rat)	IC50	0.0245	2	4
Focal adhesion kinase 1	Homo sapiens (human)	IC50	7.4000	1	1
Fructose-1,6-bisphosphatase 1	Homo sapiens (human)	IC50	1.1500	1	2
Fructose-1,6-bisphosphatase 1	Sus scrofa (pig)	IC50	10.0000	1	2
Fructose-1,6-bisphosphatase 1	Rattus norvegicus (Norway rat)	IC50	10.0000	1	2
G2/mitotic-specific cyclin-B1	Homo sapiens (human)	IC50	40.2872	1	5
Glycogen phosphorylase, muscle form	Oryctolagus cuniculus (rabbit)	IC50	0.0140	1	1
Hepatocyte growth factor receptor	Homo sapiens (human)	IC50	6.7500	2	2
Histamine H3 receptor	Rattus norvegicus (Norway rat)	IC50	1.1500	1	4
Histone deacetylase 1	Homo sapiens (human)	IC50	1.0000	1	1
Histone deacetylase 11	Homo sapiens (human)	IC50	1.0000	1	1
Histone deacetylase 2	Homo sapiens (human)	IC50	1.0000	1	1
Histone deacetylase 3	Homo sapiens (human)	IC50	1.0000	1	1
Histone deacetylase 4	Homo sapiens (human)	IC50	1.0000	1	1
Histone deacetylase 5	Homo sapiens (human)	IC50	1.0000	1	1
Histone deacetylase 6	Homo sapiens (human)	IC50	1.0000	1	1
Histone deacetylase 7	Homo sapiens (human)	IC50	1.0000	1	1
Histone deacetylase 8	Homo sapiens (human)	IC50	1.0000	1	1
Histone deacetylase 9	Homo sapiens (human)	IC50	1.0000	1	1
Insulin receptor	Homo sapiens (human)	GI50	0.5000	1	1
Insulin receptor	Homo sapiens (human)	IC50	23.3530	4	4
Insulin-like growth factor 1 receptor	Homo sapiens (human)	GI50	0.5600	1	1
Insulin-like growth factor 1 receptor	Homo sapiens (human)	IC50	742.5000	4	4
Lysine-specific histone demethylase 1A	Homo sapiens (human)	IC50	19.8900	2	2
MAP kinase-interacting serine/threonine-protein kinase 1	Homo sapiens (human)	IC50	0.5800	1	2
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens (human)	IC50	37.3000	4	4
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens (human)	Ki	16.4885	4	5
Mitogen-activated protein kinase 11	Homo sapiens (human)	IC50	6.3000	1	1
Mitogen-activated protein kinase 12	Homo sapiens (human)	IC50	6.3000	1	1
Mitogen-activated protein kinase 13	Homo sapiens (human)	IC50	6.3000	1	1
Mitogen-activated protein kinase 14	Homo sapiens (human)	IC50	3.4300	2	2
Mitogen-activated protein kinase kinase kinase 8	Homo sapiens (human)	IC50	2.2850	1	2
Multidrug resistance-associated protein 4	Homo sapiens (human)	IC50	4.6000	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)	IC50	50.0000	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)	IC50	50.0000	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)	IC50	50.0000	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)	IC50	50.0000	1	1
Platelet-derived growth factor receptor alpha	Homo sapiens (human)	IC50	9.3733	3	3
Platelet-derived growth factor receptor beta	Homo sapiens (human)	IC50	30.5557	11	11
Polyamine deacetylase HDAC10	Homo sapiens (human)	IC50	1.0000	1	1
Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)	IC50	13.9233	3	3
Potassium-transporting ATPase alpha chain 1	Sus scrofa (pig)	IC50	0.0300	1	4
Potassium-transporting ATPase subunit beta	Sus scrofa (pig)	IC50	0.0300	1	3
Prostaglandin G/H synthase 1	Ovis aries (sheep)	IC50	10.0000	1	1
Prostaglandin G/H synthase 2	Homo sapiens (human)	IC50	10.0000	1	1
Protein kinase C alpha type	Bos taurus (cattle)	IC50	40.2872	1	5
Protein kinase C alpha type	Homo sapiens (human)	IC50	100.0000	2	2
Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)	IC50	1.2200	2	2
Proto-oncogene tyrosine-protein kinase Src	Gallus gallus (chicken)	IC50	7.1078	6	13
Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)	IC50	28.6516	8	12
Quinolone resistance protein NorA	Staphylococcus aureus	IC50	9.7000	1	1
Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)	IC50	1.0816	78	111
Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)	Ki	0.0318	3	3
Receptor tyrosine-protein kinase erbB-3	Homo sapiens (human)	IC50	0.7702	18	25
Receptor tyrosine-protein kinase erbB-3	Homo sapiens (human)	Ki	0.0318	3	3
Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)	IC50	0.8182	22	32
Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)	Ki	0.0318	3	3
Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2	IC50	3.2600	1	1
Serine/threonine-protein kinase B-raf	Homo sapiens (human)	IC50	1.0300	2	2
Serine/threonine-protein kinase B-raf	Mus musculus (house mouse)	IC50	0.0600	1	1
Serine/threonine-protein kinase mTOR	Homo sapiens (human)	IC50	50.0000	1	1
Serine/threonine-protein kinase STK11	Homo sapiens (human)	IC50	10.0000	1	1
Serine/threonine-protein kinase TBK1	Homo sapiens (human)	IC50	2.2000	1	1
Sodium-dependent dopamine transporter	Rattus norvegicus (Norway rat)	IC50	0.3250	1	2
Sodium-dependent serotonin transporter	Rattus norvegicus (Norway rat)	IC50	0.5600	1	1
Solute carrier family 22 member 1	Homo sapiens (human)	IC50	16.2000	1	1
Solute carrier organic anion transporter family member 1B1	Homo sapiens (human)	IC50	21.0000	1	1
Solute carrier organic anion transporter family member 1B1	Homo sapiens (human)	Ki	21.0000	1	1
Solute carrier organic anion transporter family member 1B3	Homo sapiens (human)	IC50	44.0000	1	1
Solute carrier organic anion transporter family member 1B3	Homo sapiens (human)	Ki	41.0000	1	1
Solute carrier organic anion transporter family member 2B1	Homo sapiens (human)	IC50	0.5500	1	1
Solute carrier organic anion transporter family member 2B1	Homo sapiens (human)	Ki	0.5300	1	1
Synaptic vesicular amine transporter	Rattus norvegicus (Norway rat)	IC50	0.0010	1	2
Transcription factor p65	Homo sapiens (human)	IC50	0.0550	1	1
Type-1 angiotensin II receptor	Oryctolagus cuniculus (rabbit)	IC50	0.0073	1	1
Tyrosine-protein kinase ABL1	Homo sapiens (human)	IC50	0.4517	3	3
Tyrosine-protein kinase ABL2	Homo sapiens (human)	IC50	0.1250	1	1
Tyrosine-protein kinase Blk	Homo sapiens (human)	IC50	7.7350	2	2
Tyrosine-protein kinase BTK	Homo sapiens (human)	IC50	5.8300	1	1
Tyrosine-protein kinase Fyn	Homo sapiens (human)	IC50	75.1158	4	4
Tyrosine-protein kinase HCK	Homo sapiens (human)	IC50	0.1100	1	1
Tyrosine-protein kinase ITK/TSK	Homo sapiens (human)	IC50	30.0000	1	1
Tyrosine-protein kinase JAK2	Homo sapiens (human)	IC50	12.0000	2	2
Tyrosine-protein kinase JAK3	Homo sapiens (human)	IC50	717.5420	4	5
Tyrosine-protein kinase Lck	Homo sapiens (human)	IC50	47.0470	2	2
Tyrosine-protein kinase transforming protein Abl	Abelson murine leukemia virus	IC50	40.2872	1	5
Tyrosine-protein kinase Yes	Homo sapiens (human)	IC50	0.0153	2	2
Vascular endothelial growth factor receptor 1	Homo sapiens (human)	IC50	0.1545	2	2
Vascular endothelial growth factor receptor 2	Homo sapiens (human)	IC50	33.9247	22	24
Vascular endothelial growth factor receptor 3	Homo sapiens (human)	IC50	0.2500	1	1
von Hippel-Lindau disease tumor suppressor	Homo sapiens (human)	IC50	0.0020	2	2

Activation Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
26S proteasome regulatory subunit 6B	Homo sapiens (human)	Kd	30.0000	1	7
3-phosphoinositide-dependent protein kinase 1	Homo sapiens (human)	Kd	10.0000	2	4
5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)	Kd	22.7273	3	11
5'-AMP-activated protein kinase catalytic subunit alpha-2	Homo sapiens (human)	Kd	10.0000	2	4
5'-AMP-activated protein kinase subunit gamma-1	Homo sapiens (human)	Kd	30.0000	1	7
5'-AMP-activated protein kinase subunit gamma-2	Homo sapiens (human)	Kd	30.0000	1	7
AarF domain-containing protein kinase 1	Homo sapiens (human)	Kd	30.0000	1	7
Actin-related protein 2	Homo sapiens (human)	Kd	30.0000	1	6
Actin-related protein 3	Homo sapiens (human)	Kd	30.0000	1	7
Activated CDC42 kinase 1	Homo sapiens (human)	Kd	20.0915	3	11
Activin receptor type-1	Homo sapiens (human)	Kd	21.4655	3	11
Activin receptor type-1B	Homo sapiens (human)	Kd	22.7273	3	11
Activin receptor type-2A	Homo sapiens (human)	Kd	10.0000	2	4
Activin receptor type-2B	Homo sapiens (human)	Kd	23.3333	3	12
Acyl-CoA dehydrogenase family member 10	Homo sapiens (human)	Kd	30.6325	1	6
Acyl-CoA dehydrogenase family member 11	Homo sapiens (human)	Kd	24.8294	1	5
Adenine phosphoribosyltransferase	Homo sapiens (human)	Kd	30.0000	1	4
Adenosine kinase	Homo sapiens (human)	Kd	25.9149	1	7
Adenylate kinase 2, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	7
ADP/ATP translocase 2	Homo sapiens (human)	Kd	30.0000	1	7
ADP/ATP translocase 3	Homo sapiens (human)	Kd	30.0000	1	8
ALK tyrosine kinase receptor	Homo sapiens (human)	EC50	1.7480	1	1
ALK tyrosine kinase receptor	Homo sapiens (human)	Kd	10.4800	3	5
Angiopoietin-1 receptor	Homo sapiens (human)	Kd	10.0000	2	4
Ankyrin repeat and protein kinase domain-containing protein 1	Homo sapiens (human)	Kd	10.0000	2	4
AP2-associated protein kinase 1	Homo sapiens (human)	Kd	17.2143	5	14
ATP-dependent 6-phosphofructokinase, platelet type	Homo sapiens (human)	Kd	30.0000	1	7
ATP-dependent RNA helicase DDX1	Homo sapiens (human)	Kd	30.0000	1	7
ATP-dependent RNA helicase DDX3X	Homo sapiens (human)	Kd	30.0000	1	7
ATP-dependent RNA helicase DDX42	Homo sapiens (human)	Kd	30.0000	1	5
ATP-dependent RNA helicase DHX30	Homo sapiens (human)	Kd	30.0000	1	5
ATP-dependent translocase ABCB1	Homo sapiens (human)	EC50	2.9650	1	2
Atypical kinase COQ8A, mitochondrial	Homo sapiens (human)	Kd	22.6000	3	13
Atypical kinase COQ8B, mitochondrial	Homo sapiens (human)	Kd	6.2500	2	4
Aurora kinase A	Homo sapiens (human)	Kd	20.6308	4	13
Aurora kinase B	Homo sapiens (human)	Kd	20.2800	3	10
Aurora kinase C	Homo sapiens (human)	Kd	5.3000	2	4
BDNF/NT-3 growth factors receptor	Homo sapiens (human)	Kd	10.0000	2	4
Beta-adrenergic receptor kinase 1	Homo sapiens (human)	Kd	30.0000	1	7
BMP-2-inducible protein kinase	Homo sapiens (human)	Kd	18.4945	4	13
Bone morphogenetic protein receptor type-1A	Homo sapiens (human)	Kd	22.7273	3	11
Bone morphogenetic protein receptor type-1B	Homo sapiens (human)	Kd	25.5556	2	9
Bone morphogenetic protein receptor type-2	Homo sapiens (human)	Kd	22.7273	3	11
Breakpoint cluster region protein	Homo sapiens (human)	Kd	21.7610	1	7
Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)	EC50	0.2350	1	2
Calcium-dependent protein kinase 1	Plasmodium falciparum 3D7	Kd	10.0000	1	2
Calcium/calmodulin-dependent protein kinase kinase 1	Homo sapiens (human)	Kd	10.0000	2	4
Calcium/calmodulin-dependent protein kinase kinase 2	Homo sapiens (human)	Kd	23.3333	3	12
Calcium/calmodulin-dependent protein kinase type 1	Homo sapiens (human)	Kd	10.0000	2	4
Calcium/calmodulin-dependent protein kinase type 1D	Homo sapiens (human)	Kd	10.0000	2	4
Calcium/calmodulin-dependent protein kinase type 1G	Homo sapiens (human)	Kd	14.0000	3	5
Calcium/calmodulin-dependent protein kinase type II subunit alpha	Homo sapiens (human)	Kd	10.0000	2	4
Calcium/calmodulin-dependent protein kinase type II subunit beta	Homo sapiens (human)	Kd	10.0000	2	4
Calcium/calmodulin-dependent protein kinase type II subunit delta	Homo sapiens (human)	Kd	22.4000	3	11
Calcium/calmodulin-dependent protein kinase type II subunit gamma	Homo sapiens (human)	Kd	23.3333	3	12
Calcium/calmodulin-dependent protein kinase type IV	Homo sapiens (human)	Kd	22.7273	3	11
cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)	Kd	24.2857	3	14
cAMP-dependent protein kinase catalytic subunit beta	Homo sapiens (human)	Kd	23.8462	3	13
cAMP-dependent protein kinase catalytic subunit gamma	Homo sapiens (human)	Kd	30.0000	1	5
cAMP-dependent protein kinase catalytic subunit PRKX	Homo sapiens (human)	Kd	10.0000	2	4
cAMP-dependent protein kinase type II-alpha regulatory subunit	Homo sapiens (human)	Kd	30.0000	1	6
Casein kinase I isoform alpha	Homo sapiens (human)	Kd	25.5556	2	9
Casein kinase I isoform alpha-like	Homo sapiens (human)	Kd	10.0000	2	4
Casein kinase I isoform delta	Homo sapiens (human)	Kd	20.9273	3	11
Casein kinase I isoform epsilon	Homo sapiens (human)	Kd	18.6133	4	12
Casein kinase I isoform gamma-1	Homo sapiens (human)	Kd	23.3333	3	12
Casein kinase I isoform gamma-2	Homo sapiens (human)	Kd	22.7273	3	11
Casein kinase I isoform gamma-3	Homo sapiens (human)	Kd	22.7273	3	11
Casein kinase II subunit alpha	Homo sapiens (human)	Kd	10.0000	2	4
Casein kinase II subunit alpha'	Homo sapiens (human)	Kd	22.0000	3	10
Cell division control protein 2 homolog	Plasmodium falciparum 3D7	Kd	10.0000	1	2
Cell division cycle 7-related protein kinase	Homo sapiens (human)	Kd	30.0000	1	6
cGMP-dependent protein kinase 1	Homo sapiens (human)	Kd	22.7273	3	11
cGMP-dependent protein kinase 2	Homo sapiens (human)	Kd	10.0000	2	4
Choline-phosphate cytidylyltransferase A	Homo sapiens (human)	Kd	30.0000	1	4
Chromodomain-helicase-DNA-binding protein 4	Homo sapiens (human)	Kd	30.0000	1	7
Citron Rho-interacting kinase	Homo sapiens (human)	Kd	20.3300	3	12
Cyclin-dependent kinase 1	Homo sapiens (human)	Kd	30.0000	1	7
Cyclin-dependent kinase 11A	Homo sapiens (human)	Kd	10.0000	2	4
Cyclin-dependent kinase 11B	Homo sapiens (human)	Kd	10.0000	2	4
Cyclin-dependent kinase 12	Homo sapiens (human)	Kd	30.0000	1	7
Cyclin-dependent kinase 13	Homo sapiens (human)	Kd	26.3636	2	11
Cyclin-dependent kinase 14	Homo sapiens (human)	Kd	10.0000	2	4
Cyclin-dependent kinase 15	Homo sapiens (human)	Kd	10.0000	1	2
Cyclin-dependent kinase 16	Homo sapiens (human)	Kd	22.7273	3	11
Cyclin-dependent kinase 17	Homo sapiens (human)	Kd	22.7273	3	11
Cyclin-dependent kinase 18	Homo sapiens (human)	Kd	10.0000	2	4
Cyclin-dependent kinase 19	Homo sapiens (human)	Kd	10.0000	2	4
Cyclin-dependent kinase 2	Homo sapiens (human)	Kd	22.7273	3	11
Cyclin-dependent kinase 3	Homo sapiens (human)	Kd	22.7273	3	11
Cyclin-dependent kinase 4	Homo sapiens (human)	Kd	23.3333	3	12
Cyclin-dependent kinase 6	Homo sapiens (human)	Kd	30.0000	1	7
Cyclin-dependent kinase 7	Homo sapiens (human)	Kd	22.5508	3	12
Cyclin-dependent kinase 8	Homo sapiens (human)	Kd	10.0000	2	4
Cyclin-dependent kinase 9	Homo sapiens (human)	Kd	22.7273	3	11
Cyclin-dependent kinase-like 1	Homo sapiens (human)	Kd	10.0000	1	2
Cyclin-dependent kinase-like 2	Homo sapiens (human)	Kd	10.0000	1	2
Cyclin-dependent kinase-like 3	Homo sapiens (human)	Kd	10.0000	1	2
Cyclin-dependent kinase-like 5	Homo sapiens (human)	Kd	24.2857	2	7
Cyclin-dependent-like kinase 5	Homo sapiens (human)	Kd	22.7273	3	11
Cyclin-G-associated kinase	Homo sapiens (human)	Kd	3.1749	16	29
Cysteine--tRNA ligase, cytoplasmic	Homo sapiens (human)	Kd	24.0024	1	5
Cytochrome c1, heme protein, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	8
Cytoplasmic tyrosine-protein kinase BMX	Homo sapiens (human)	Kd	10.0000	2	4
dCTP pyrophosphatase 1	Homo sapiens (human)	Kd	26.6318	1	8
Death-associated protein kinase 1	Homo sapiens (human)	Kd	10.0000	2	4
Death-associated protein kinase 2	Homo sapiens (human)	Kd	10.0000	2	4
Death-associated protein kinase 3	Homo sapiens (human)	Kd	7.9000	3	6
Delta(24)-sterol reductase	Homo sapiens (human)	Kd	30.0000	1	8
Deoxycytidine kinase	Homo sapiens (human)	Kd	30.0000	1	8
Discoidin domain-containing receptor 2	Homo sapiens (human)	Kd	22.5629	3	11
DNA replication licensing factor MCM4	Homo sapiens (human)	Kd	30.0000	1	7
DNA topoisomerase 2-alpha	Homo sapiens (human)	Kd	30.0000	1	5
DNA topoisomerase 2-beta	Homo sapiens (human)	Kd	30.0000	1	7
DnaJ homolog subfamily A member 1	Homo sapiens (human)	Kd	30.0000	1	7
Dual serine/threonine and tyrosine protein kinase	Homo sapiens (human)	Kd	10.0000	1	2
Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)	Kd	22.7273	3	11
Dual specificity mitogen-activated protein kinase kinase 2	Homo sapiens (human)	Kd	22.7273	3	11
Dual specificity mitogen-activated protein kinase kinase 3	Homo sapiens (human)	Kd	22.7273	3	11
Dual specificity mitogen-activated protein kinase kinase 4	Homo sapiens (human)	Kd	20.0000	3	8
Dual specificity mitogen-activated protein kinase kinase 5	Homo sapiens (human)	Kd	20.3665	2	11
Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)	Kd	22.7273	3	11
Dual specificity mitogen-activated protein kinase kinase 7	Homo sapiens (human)	Kd	10.0000	1	2
Dual specificity protein kinase CLK1	Homo sapiens (human)	Kd	22.7273	3	11
Dual specificity protein kinase CLK2	Homo sapiens (human)	Kd	21.1111	3	9
Dual specificity protein kinase CLK3	Homo sapiens (human)	Kd	21.1111	3	9
Dual specificity protein kinase CLK4	Homo sapiens (human)	Kd	16.6667	3	6
Dual specificity protein kinase TTK	Homo sapiens (human)	Kd	19.2125	3	8
Dual specificity testis-specific protein kinase 1	Homo sapiens (human)	Kd	21.1111	3	9
Dual specificity testis-specific protein kinase 2	Homo sapiens (human)	Kd	30.0000	1	5
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens (human)	Kd	26.0000	2	10
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	Homo sapiens (human)	Kd	14.0000	3	5
Dual specificity tyrosine-phosphorylation-regulated kinase 2	Homo sapiens (human)	Kd	5.6500	1	2
Dynamin-like 120 kDa protein, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	7
Echinoderm microtubule-associated protein-like 4	Homo sapiens (human)	EC50	1.7480	1	1
eIF-2-alpha kinase GCN2	Homo sapiens (human)	Kd	7.2000	2	4
EKC/KEOPS complex subunit TP53RK	Homo sapiens (human)	Kd	30.0000	1	7
Electron transfer flavoprotein subunit beta	Homo sapiens (human)	Kd	30.0000	1	5
Elongation factor Tu, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	8
Ephrin type-A receptor 1	Homo sapiens (human)	Kd	16.4461	3	9
Ephrin type-A receptor 2	Homo sapiens (human)	Kd	20.7453	3	11
Ephrin type-A receptor 3	Homo sapiens (human)	Kd	5.0750	2	4
Ephrin type-A receptor 4	Homo sapiens (human)	Kd	18.5869	3	11
Ephrin type-A receptor 5	Homo sapiens (human)	Kd	19.4204	3	12
Ephrin type-A receptor 6	Homo sapiens (human)	Kd	0.7600	4	7
Ephrin type-A receptor 7	Homo sapiens (human)	Kd	20.2800	3	10
Ephrin type-A receptor 8	Homo sapiens (human)	Kd	1.3700	2	4
Ephrin type-B receptor 1	Homo sapiens (human)	Kd	5.9400	3	5
Ephrin type-B receptor 2	Homo sapiens (human)	Kd	16.8848	4	12
Ephrin type-B receptor 3	Homo sapiens (human)	Kd	22.7273	3	11
Ephrin type-B receptor 4	Homo sapiens (human)	Kd	15.6359	3	11
Ephrin type-B receptor 6	Homo sapiens (human)	Kd	24.4900	2	10
Epidermal growth factor receptor	Homo sapiens (human)	EC50	1.3817	23	28
Epidermal growth factor receptor	Homo sapiens (human)	Kd	0.0588	34	77
Epithelial discoidin domain-containing receptor 1	Homo sapiens (human)	Kd	18.8003	3	11
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B	Homo sapiens (human)	Kd	30.0000	1	2
Eukaryotic translation initiation factor 2-alpha kinase 1	Homo sapiens (human)	Kd	26.0000	2	10
Eukaryotic translation initiation factor 5B	Homo sapiens (human)	Kd	30.0000	1	6
Exosome RNA helicase MTR4	Homo sapiens (human)	Kd	30.0000	1	7
Ferrochelatase, mitochondrial	Homo sapiens (human)	Kd	19.3208	2	9
Fibroblast growth factor receptor 1	Homo sapiens (human)	Kd	23.3333	3	12
Fibroblast growth factor receptor 2	Homo sapiens (human)	Kd	8.3800	3	5
Fibroblast growth factor receptor 3	Homo sapiens (human)	Kd	10.0000	4	8
Fibroblast growth factor receptor 4	Homo sapiens (human)	Kd	10.0000	2	4
Focal adhesion kinase 1	Homo sapiens (human)	Kd	22.7273	3	11
G protein-coupled receptor kinase 4	Homo sapiens (human)	Kd	8.6500	1	2
G protein-coupled receptor kinase 6	Homo sapiens (human)	Kd	30.0000	1	7
General transcription and DNA repair factor IIH helicase subunit XPD	Homo sapiens (human)	Kd	30.0000	1	7
Glycine--tRNA ligase	Homo sapiens (human)	Kd	30.0000	1	7
Glycogen phosphorylase, brain form	Homo sapiens (human)	Kd	30.0000	1	7
Glycogen phosphorylase, liver form	Homo sapiens (human)	Kd	30.0000	1	7
Glycogen synthase kinase-3 alpha	Homo sapiens (human)	Kd	22.7273	3	11
Glycogen synthase kinase-3 beta	Homo sapiens (human)	Kd	23.3333	3	12
GTP-binding nuclear protein Ran	Homo sapiens (human)	Kd	30.0000	1	8
Guanine nucleotide-binding protein G(i) subunit alpha-2	Homo sapiens (human)	Kd	30.0000	1	7
Heme oxygenase 2	Homo sapiens (human)	Kd	30.0000	1	7
Hepatocyte growth factor receptor	Homo sapiens (human)	Kd	12.1547	5	14
High affinity nerve growth factor receptor	Homo sapiens (human)	Kd	22.0000	3	10
Homeodomain-interacting protein kinase 1	Homo sapiens (human)	Kd	10.0000	1	2
Homeodomain-interacting protein kinase 2	Homo sapiens (human)	Kd	10.0000	1	2
Homeodomain-interacting protein kinase 3	Homo sapiens (human)	Kd	10.0000	1	2
Homeodomain-interacting protein kinase 4	Homo sapiens (human)	Kd	0.6350	1	2
Hormonally up-regulated neu tumor-associated kinase	Homo sapiens (human)	Kd	10.0000	1	2
Inhibitor of nuclear factor kappa-B kinase subunit alpha	Homo sapiens (human)	Kd	10.0000	1	2
Inhibitor of nuclear factor kappa-B kinase subunit beta	Homo sapiens (human)	Kd	10.0000	1	2
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	Homo sapiens (human)	Kd	22.7273	3	11
Inosine-5'-monophosphate dehydrogenase 2	Homo sapiens (human)	Kd	30.0000	1	6
Insulin receptor	Homo sapiens (human)	Kd	22.7273	3	11
Insulin receptor-related protein	Homo sapiens (human)	Kd	10.0000	2	4
Insulin-like growth factor 1 receptor	Homo sapiens (human)	Kd	23.3333	3	12
Integrin-linked protein kinase	Homo sapiens (human)	Kd	30.0000	1	6
Interferon-induced, double-stranded RNA-activated protein kinase	Homo sapiens (human)	Kd	5.6500	2	4
Interleukin-1 receptor-associated kinase 1	Homo sapiens (human)	Kd	24.4521	2	9
Interleukin-1 receptor-associated kinase 3	Homo sapiens (human)	Kd	21.9167	3	12
Interleukin-1 receptor-associated kinase 4	Homo sapiens (human)	Kd	25.0540	2	10
Isoleucine--tRNA ligase, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	2
Leucine-rich repeat serine/threonine-protein kinase 2	Homo sapiens (human)	Kd	6.9250	2	4
Leukocyte tyrosine kinase receptor	Homo sapiens (human)	Kd	4.3200	2	4
Leukotriene C4 synthase	Cavia porcellus (domestic guinea pig)	Kd	10.0000	1	2
LIM domain kinase 1	Homo sapiens (human)	Kd	20.8860	3	12
LIM domain kinase 2	Homo sapiens (human)	Kd	22.6475	3	12
Long-chain-fatty-acid--CoA ligase 5	Homo sapiens (human)	Kd	30.0000	1	5
Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)	Kd	10.0000	2	4
Macrophage-stimulating protein receptor	Homo sapiens (human)	Kd	25.5556	2	9
MAP kinase-activated protein kinase 2	Homo sapiens (human)	Kd	22.7273	3	11
MAP kinase-activated protein kinase 3	Homo sapiens (human)	Kd	30.0000	1	4
MAP kinase-activated protein kinase 5	Homo sapiens (human)	Kd	22.0000	3	10
MAP kinase-interacting serine/threonine-protein kinase 1	Homo sapiens (human)	Kd	0.4900	2	4
MAP kinase-interacting serine/threonine-protein kinase 2	Homo sapiens (human)	Kd	2.5600	3	6
MAP/microtubule affinity-regulating kinase 3	Homo sapiens (human)	Kd	22.7273	3	11
MAP/microtubule affinity-regulating kinase 4	Homo sapiens (human)	Kd	23.3333	3	12
Mast/stem cell growth factor receptor Kit	Homo sapiens (human)	Kd	8.0938	16	32
Maternal embryonic leucine zipper kinase	Homo sapiens (human)	Kd	22.7273	3	11
Megakaryocyte-associated tyrosine-protein kinase	Homo sapiens (human)	Kd	10.0000	1	2
Membrane-associated progesterone receptor component 1	Homo sapiens (human)	Kd	30.0000	1	2
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens (human)	Kd	22.7273	3	11
Microtubule-associated serine/threonine-protein kinase 1	Homo sapiens (human)	Kd	10.0000	1	2
Midasin	Homo sapiens (human)	Kd	30.0000	1	7
Misshapen-like kinase 1	Homo sapiens (human)	Kd	18.6200	2	5
Mitogen-activated protein kinase 1	Homo sapiens (human)	Kd	22.7273	3	11
Mitogen-activated protein kinase 10	Homo sapiens (human)	Kd	19.4167	4	12
Mitogen-activated protein kinase 11	Homo sapiens (human)	Kd	22.7273	3	11
Mitogen-activated protein kinase 12	Homo sapiens (human)	Kd	10.0000	2	4
Mitogen-activated protein kinase 13	Homo sapiens (human)	Kd	10.0000	1	2
Mitogen-activated protein kinase 14	Homo sapiens (human)	Kd	22.7273	3	11
Mitogen-activated protein kinase 15	Homo sapiens (human)	Kd	23.8462	3	13
Mitogen-activated protein kinase 3	Homo sapiens (human)	Kd	23.3333	3	12
Mitogen-activated protein kinase 4	Homo sapiens (human)	Kd	2.8000	2	4
Mitogen-activated protein kinase 6	Homo sapiens (human)	Kd	5.8000	2	4
Mitogen-activated protein kinase 7	Homo sapiens (human)	Kd	23.3333	3	12
Mitogen-activated protein kinase 8	Homo sapiens (human)	Kd	23.3333	3	12
Mitogen-activated protein kinase 9	Homo sapiens (human)	Kd	19.2214	4	14
Mitogen-activated protein kinase kinase kinase 1	Homo sapiens (human)	Kd	22.4719	2	9
Mitogen-activated protein kinase kinase kinase 10	Homo sapiens (human)	Kd	10.0000	2	4
Mitogen-activated protein kinase kinase kinase 11	Homo sapiens (human)	Kd	22.7273	3	11
Mitogen-activated protein kinase kinase kinase 12	Homo sapiens (human)	Kd	10.0000	1	2
Mitogen-activated protein kinase kinase kinase 13	Homo sapiens (human)	Kd	10.0000	1	2
Mitogen-activated protein kinase kinase kinase 15	Homo sapiens (human)	Kd	10.0000	1	2
Mitogen-activated protein kinase kinase kinase 19	Homo sapiens (human)	Kd	0.1325	1	2
Mitogen-activated protein kinase kinase kinase 2	Homo sapiens (human)	Kd	23.9778	2	9
Mitogen-activated protein kinase kinase kinase 20	Homo sapiens (human)	Kd	21.2398	3	11
Mitogen-activated protein kinase kinase kinase 3	Homo sapiens (human)	Kd	24.4400	2	10
Mitogen-activated protein kinase kinase kinase 4	Homo sapiens (human)	Kd	20.1990	3	11
Mitogen-activated protein kinase kinase kinase 5	Homo sapiens (human)	Kd	22.7273	3	11
Mitogen-activated protein kinase kinase kinase 6	Homo sapiens (human)	Kd	25.5556	2	9
Mitogen-activated protein kinase kinase kinase 7	Homo sapiens (human)	Kd	10.0000	1	2
Mitogen-activated protein kinase kinase kinase 9	Homo sapiens (human)	Kd	10.0000	2	4
Mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens (human)	Kd	22.7273	3	11
Mitogen-activated protein kinase kinase kinase kinase 2	Homo sapiens (human)	Kd	23.3534	2	10
Mitogen-activated protein kinase kinase kinase kinase 3	Homo sapiens (human)	Kd	22.7273	3	11
Mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens (human)	Kd	20.7254	3	11
Mitogen-activated protein kinase kinase kinase kinase 5	Homo sapiens (human)	Kd	24.5649	3	11
Mitotic checkpoint serine/threonine-protein kinase BUB1	Homo sapiens (human)	Kd	25.7304	1	7
Multifunctional protein ADE2	Homo sapiens (human)	Kd	30.0000	1	8
Muscle, skeletal receptor tyrosine-protein kinase	Homo sapiens (human)	Kd	10.0000	2	4
Myosin light chain kinase 2, skeletal/cardiac muscle	Homo sapiens (human)	Kd	1.4350	2	4
Myosin light chain kinase 3	Homo sapiens (human)	Kd	25.0000	2	8
Myosin light chain kinase family member 4	Homo sapiens (human)	Kd	10.0000	2	4
Myosin light chain kinase, smooth muscle	Gallus gallus (chicken)	Kd	10.0000	1	2
Myosin light chain kinase, smooth muscle	Homo sapiens (human)	Kd	22.7273	3	11
Myosin-10	Homo sapiens (human)	Kd	30.0000	1	2
Myosin-14	Homo sapiens (human)	Kd	30.0000	1	6
Myosin-IIIa	Homo sapiens (human)	Kd	10.0000	2	4
Myosin-IIIb	Homo sapiens (human)	Kd	10.0000	2	4
Myotonin-protein kinase	Homo sapiens (human)	Kd	4.9000	2	4
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	Homo sapiens (human)	Kd	30.0000	1	6
Non-receptor tyrosine-protein kinase TNK1	Homo sapiens (human)	Kd	18.4493	3	11
Non-receptor tyrosine-protein kinase TYK2	Homo sapiens (human)	Kd	20.1846	4	13
NT-3 growth factor receptor	Homo sapiens (human)	Kd	10.0000	2	4
NUAK family SNF1-like kinase 1	Homo sapiens (human)	Kd	10.0000	2	4
NUAK family SNF1-like kinase 2	Homo sapiens (human)	Kd	22.2364	3	11
Nucleolar GTP-binding protein 1	Homo sapiens (human)	Kd	30.0000	1	7
Nucleoside diphosphate kinase B	Homo sapiens (human)	Kd	30.0000	1	1
Obg-like ATPase 1	Homo sapiens (human)	Kd	30.0000	1	6
PAS domain-containing serine/threonine-protein kinase	Homo sapiens (human)	Kd	30.0000	1	5
Peripheral plasma membrane protein CASK	Homo sapiens (human)	Kd	10.0000	1	2
Peroxisomal acyl-coenzyme A oxidase 1	Homo sapiens (human)	Kd	30.0000	1	7
Peroxisomal acyl-coenzyme A oxidase 3	Homo sapiens (human)	Kd	30.0000	1	7
Phenylalanine--tRNA ligase beta subunit	Homo sapiens (human)	Kd	30.0000	1	7
Phosphatidylethanolamine-binding protein 1	Homo sapiens (human)	Kd	30.0000	1	5
Phosphatidylinositol 4-kinase beta	Homo sapiens (human)	Kd	10.0000	1	2
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	Homo sapiens (human)	Kd	10.0000	1	2
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	Homo sapiens (human)	Kd	10.0000	1	2
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha	Homo sapiens (human)	Kd	10.0000	2	4
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma	Homo sapiens (human)	Kd	10.0000	1	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)	Kd	10.0000	12	24
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)	Kd	10.0000	1	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)	Kd	10.0000	1	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)	Kd	10.0000	1	2
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	Homo sapiens (human)	Kd	30.0000	1	5
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	Homo sapiens (human)	Kd	10.0000	2	4
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	Homo sapiens (human)	Kd	22.1473	2	10
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	Homo sapiens (human)	Kd	20.7583	4	12
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	Homo sapiens (human)	Kd	6.8500	2	4
Platelet-derived growth factor receptor alpha	Homo sapiens (human)	Kd	5.9000	2	4
Platelet-derived growth factor receptor beta	Homo sapiens (human)	Kd	19.2894	3	11
Probable ATP-dependent RNA helicase DDX6	Homo sapiens (human)	Kd	30.0000	1	7
Prostaglandin G/H synthase 2	Homo sapiens (human)	Kd	10.0000	1	2
Protein kinase C alpha type	Homo sapiens (human)	Kd	30.0000	1	8
Protein kinase C beta type	Homo sapiens (human)	Kd	30.0000	1	8
Protein kinase C delta type	Homo sapiens (human)	Kd	23.8462	3	13
Protein kinase C epsilon type	Homo sapiens (human)	Kd	10.0000	2	4
Protein kinase C eta type	Homo sapiens (human)	Kd	10.0000	2	4
Protein kinase C iota type	Homo sapiens (human)	Kd	25.5556	2	9
Protein kinase C theta type	Homo sapiens (human)	Kd	22.0000	3	10
Protein kinase C zeta type	Homo sapiens (human)	Kd	30.0000	1	4
Protein-tyrosine kinase 2-beta	Homo sapiens (human)	Kd	23.3333	3	12
Protein-tyrosine kinase 6	Homo sapiens (human)	Kd	20.2002	3	11
Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)	Kd	10.8518	7	19
Proto-oncogene tyrosine-protein kinase ROS	Homo sapiens (human)	Kd	10.0000	2	4
Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)	Kd	17.3769	4	13
Putative heat shock protein HSP 90-beta 2	Homo sapiens (human)	Kd	30.0000	1	6
Putative nucleoside diphosphate kinase	Homo sapiens (human)	Kd	30.0000	1	1
Pyridoxal kinase	Homo sapiens (human)	Kd	30.0000	1	7
Rab-like protein 3	Homo sapiens (human)	Kd	30.0000	1	5
RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)	Kd	22.7273	3	11
RAC-beta serine/threonine-protein kinase	Homo sapiens (human)	Kd	22.7273	3	11
RAC-gamma serine/threonine-protein kinase	Homo sapiens (human)	Kd	23.3333	3	12
RAF proto-oncogene serine/threonine-protein kinase	Homo sapiens (human)	Kd	10.0000	2	4
Ras-related C3 botulinum toxin substrate 1	Homo sapiens (human)	Kd	30.0000	1	1
Ras-related protein Rab-10	Homo sapiens (human)	Kd	30.0000	1	6
Ras-related protein Rab-27A	Homo sapiens (human)	Kd	30.0000	1	8
Ras-related protein Rab-6A	Homo sapiens (human)	Kd	30.0000	1	7
Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)	EC50	0.1220	1	1
Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)	Kd	4.3500	3	6
Receptor tyrosine-protein kinase erbB-3	Homo sapiens (human)	Kd	0.9450	1	2
Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)	Kd	0.3200	1	2
Receptor-interacting serine/threonine-protein kinase 1	Homo sapiens (human)	Kd	10.0000	2	4
Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)	Kd	5.9810	4	13
Receptor-interacting serine/threonine-protein kinase 3	Homo sapiens (human)	Kd	13.9806	1	7
Receptor-interacting serine/threonine-protein kinase 4	Homo sapiens (human)	Kd	7.4500	1	2
Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)	Kd	9.0613	13	31
Rho-associated protein kinase 1	Homo sapiens (human)	Kd	25.5556	2	9
Rho-associated protein kinase 2	Homo sapiens (human)	Kd	25.5556	2	9
Rhodopsin kinase GRK1	Homo sapiens (human)	Kd	10.0000	1	2
Rhodopsin kinase GRK7	Homo sapiens (human)	Kd	10.0000	1	2
Ribosomal protein S6 kinase alpha-1	Homo sapiens (human)	Kd	19.3333	5	15
Ribosomal protein S6 kinase alpha-2	Homo sapiens (human)	Kd	10.0000	4	8
Ribosomal protein S6 kinase alpha-3	Homo sapiens (human)	Kd	22.7273	3	11
Ribosomal protein S6 kinase alpha-4	Homo sapiens (human)	Kd	18.3467	5	15
Ribosomal protein S6 kinase alpha-5	Homo sapiens (human)	Kd	20.0000	5	16
Ribosomal protein S6 kinase alpha-6	Homo sapiens (human)	Kd	19.3333	5	15
Ribosomal protein S6 kinase beta-1	Homo sapiens (human)	Kd	25.5556	2	9
Ribosyldihydronicotinamide dehydrogenase [quinone]	Homo sapiens (human)	Kd	26.2369	1	7
RNA cytidine acetyltransferase	Homo sapiens (human)	Kd	30.0000	1	7
S-adenosylmethionine synthase isoform type-2	Homo sapiens (human)	Kd	30.0000	1	8
Septin-9	Homo sapiens (human)	Kd	30.0000	1	7
Serine/threonine-protein kinase 10	Homo sapiens (human)	Kd	12.1801	5	14
Serine/threonine-protein kinase 16	Homo sapiens (human)	Kd	22.7273	3	11
Serine/threonine-protein kinase 17A	Homo sapiens (human)	Kd	4.6400	3	5
Serine/threonine-protein kinase 17B	Homo sapiens (human)	Kd	6.7000	3	5
Serine/threonine-protein kinase 24	Homo sapiens (human)	Kd	20.0000	3	8
Serine/threonine-protein kinase 25	Homo sapiens (human)	Kd	10.0000	2	4
Serine/threonine-protein kinase 26	Homo sapiens (human)	Kd	22.7273	3	11
Serine/threonine-protein kinase 3	Homo sapiens (human)	Kd	23.3333	3	12
Serine/threonine-protein kinase 32A	Homo sapiens (human)	Kd	10.0000	1	2
Serine/threonine-protein kinase 32B	Homo sapiens (human)	Kd	10.0000	2	4
Serine/threonine-protein kinase 32C	Homo sapiens (human)	Kd	10.0000	2	4
Serine/threonine-protein kinase 33	Homo sapiens (human)	Kd	10.0000	2	4
Serine/threonine-protein kinase 35	Homo sapiens (human)	Kd	10.0000	1	2
Serine/threonine-protein kinase 36	Homo sapiens (human)	Kd	7.5250	2	4
Serine/threonine-protein kinase 38	Homo sapiens (human)	Kd	20.0000	2	4
Serine/threonine-protein kinase 38-like	Homo sapiens (human)	Kd	20.0000	3	8
Serine/threonine-protein kinase 4	Homo sapiens (human)	Kd	23.3333	3	12
Serine/threonine-protein kinase A-Raf	Homo sapiens (human)	Kd	30.0000	1	8
Serine/threonine-protein kinase ATR	Homo sapiens (human)	Kd	30.0000	1	3
Serine/threonine-protein kinase B-raf	Homo sapiens (human)	Kd	19.3333	5	15
Serine/threonine-protein kinase BRSK1	Homo sapiens (human)	Kd	10.0000	2	4
Serine/threonine-protein kinase BRSK2	Homo sapiens (human)	Kd	10.0000	2	4
Serine/threonine-protein kinase Chk1	Homo sapiens (human)	Kd	23.3333	3	12
Serine/threonine-protein kinase Chk2	Homo sapiens (human)	Kd	5.4000	1	2
Serine/threonine-protein kinase D1	Homo sapiens (human)	Kd	8.3750	2	4
Serine/threonine-protein kinase D2	Homo sapiens (human)	Kd	23.3333	3	12
Serine/threonine-protein kinase D3	Homo sapiens (human)	Kd	22.7273	3	11
Serine/threonine-protein kinase DCLK1	Homo sapiens (human)	Kd	10.0000	2	4
Serine/threonine-protein kinase DCLK2	Homo sapiens (human)	Kd	10.0000	2	4
Serine/threonine-protein kinase DCLK3	Homo sapiens (human)	Kd	8.2250	2	4
Serine/threonine-protein kinase ICK	Homo sapiens (human)	Kd	25.5556	2	9
Serine/threonine-protein kinase LATS1	Homo sapiens (human)	Kd	23.3333	3	12
Serine/threonine-protein kinase LATS2	Homo sapiens (human)	Kd	10.0000	2	4
Serine/threonine-protein kinase MAK	Homo sapiens (human)	Kd	10.0000	1	2
Serine/threonine-protein kinase MARK1	Homo sapiens (human)	Kd	10.0000	2	4
Serine/threonine-protein kinase MARK2	Homo sapiens (human)	Kd	22.7273	3	11
Serine/threonine-protein kinase MRCK alpha	Homo sapiens (human)	Kd	23.3333	3	12
Serine/threonine-protein kinase MRCK beta	Homo sapiens (human)	Kd	22.7273	3	11
Serine/threonine-protein kinase MRCK gamma	Homo sapiens (human)	Kd	20.6800	3	10
Serine/threonine-protein kinase mTOR	Homo sapiens (human)	Kd	10.0000	1	2
Serine/threonine-protein kinase N1	Homo sapiens (human)	Kd	22.7273	3	11
Serine/threonine-protein kinase N2	Homo sapiens (human)	Kd	23.3333	3	12
Serine/threonine-protein kinase N3	Homo sapiens (human)	Kd	30.0000	1	4
Serine/threonine-protein kinase Nek1	Homo sapiens (human)	Kd	22.7273	3	11
Serine/threonine-protein kinase Nek11	Homo sapiens (human)	Kd	10.0000	1	2
Serine/threonine-protein kinase Nek2	Homo sapiens (human)	Kd	22.7273	3	11
Serine/threonine-protein kinase Nek3	Homo sapiens (human)	Kd	26.4542	2	9
Serine/threonine-protein kinase Nek4	Homo sapiens (human)	Kd	10.0000	1	2
Serine/threonine-protein kinase Nek5	Homo sapiens (human)	Kd	10.0000	2	4
Serine/threonine-protein kinase Nek6	Homo sapiens (human)	Kd	10.0000	2	4
Serine/threonine-protein kinase Nek7	Homo sapiens (human)	Kd	21.1111	3	9
Serine/threonine-protein kinase Nek9	Homo sapiens (human)	Kd	23.8462	3	13
Serine/threonine-protein kinase NIM1	Homo sapiens (human)	Kd	10.0000	1	2
Serine/threonine-protein kinase NLK	Homo sapiens (human)	Kd	22.8500	3	12
Serine/threonine-protein kinase OSR1	Homo sapiens (human)	Kd	10.0000	1	2
Serine/threonine-protein kinase PAK 1	Homo sapiens (human)	Kd	10.0000	2	4
Serine/threonine-protein kinase PAK 2	Homo sapiens (human)	Kd	22.7273	3	11
Serine/threonine-protein kinase PAK 3	Homo sapiens (human)	Kd	10.0000	2	4
Serine/threonine-protein kinase PAK 4	Homo sapiens (human)	Kd	22.7273	3	11
Serine/threonine-protein kinase PAK 5	Homo sapiens (human)	Kd	10.0000	2	4
Serine/threonine-protein kinase PAK 6	Homo sapiens (human)	Kd	20.0000	3	8
Serine/threonine-protein kinase pim-1	Homo sapiens (human)	Kd	22.7273	3	11
Serine/threonine-protein kinase pim-2	Homo sapiens (human)	Kd	21.1111	3	9
Serine/threonine-protein kinase pim-3	Homo sapiens (human)	Kd	7.9000	2	4
Serine/threonine-protein kinase PknB	Mycobacterium tuberculosis H37Rv	Kd	10.0000	1	2
Serine/threonine-protein kinase PLK1	Homo sapiens (human)	Kd	18.5714	3	7
Serine/threonine-protein kinase PLK2	Homo sapiens (human)	Kd	10.0000	1	2
Serine/threonine-protein kinase PLK3	Homo sapiens (human)	Kd	10.0000	2	4
Serine/threonine-protein kinase PLK4	Homo sapiens (human)	Kd	21.9909	3	11
Serine/threonine-protein kinase PRP4 homolog	Homo sapiens (human)	Kd	10.0000	1	2
Serine/threonine-protein kinase receptor R3	Homo sapiens (human)	Kd	10.0000	2	4
Serine/threonine-protein kinase RIO1	Homo sapiens (human)	Kd	10.0000	2	4
Serine/threonine-protein kinase RIO2	Homo sapiens (human)	Kd	10.0000	1	2
Serine/threonine-protein kinase RIO3	Homo sapiens (human)	Kd	10.0000	2	4
Serine/threonine-protein kinase SBK1	Homo sapiens (human)	Kd	0.8800	1	2
Serine/threonine-protein kinase Sgk3	Homo sapiens (human)	Kd	10.0000	1	2
Serine/threonine-protein kinase SIK1	Homo sapiens (human)	Kd	10.0000	2	4
Serine/threonine-protein kinase SIK2	Homo sapiens (human)	Kd	21.6905	3	11
Serine/threonine-protein kinase SIK3	Homo sapiens (human)	Kd	26.0000	2	10
Serine/threonine-protein kinase STK11	Homo sapiens (human)	Kd	22.7273	3	11
Serine/threonine-protein kinase TAO1	Homo sapiens (human)	Kd	25.5556	2	9
Serine/threonine-protein kinase TAO2	Homo sapiens (human)	Kd	25.5556	2	9
Serine/threonine-protein kinase TAO3	Homo sapiens (human)	Kd	25.5556	2	9
Serine/threonine-protein kinase TBK1	Homo sapiens (human)	Kd	24.7889	2	9
Serine/threonine-protein kinase TNNI3K	Homo sapiens (human)	Kd	5.2850	2	4
Serine/threonine-protein kinase tousled-like 1	Homo sapiens (human)	Kd	10.0000	2	4
Serine/threonine-protein kinase tousled-like 2	Homo sapiens (human)	Kd	10.0000	2	4
Serine/threonine-protein kinase ULK1	Homo sapiens (human)	Kd	25.5556	2	9
Serine/threonine-protein kinase ULK2	Homo sapiens (human)	Kd	10.0000	1	2
Serine/threonine-protein kinase ULK3	Homo sapiens (human)	Kd	24.5467	2	9
Serine/threonine-protein kinase ULK3	Mus musculus (house mouse)	Kd	1.0150	1	2
Serine/threonine-protein kinase VRK2	Homo sapiens (human)	Kd	10.0000	1	2
Serine/threonine-protein kinase/endoribonuclease IRE1	Homo sapiens (human)	Kd	25.5556	2	9
Serine/threonine-protein kinase/endoribonuclease IRE2	Homo sapiens (human)	Kd	30.0000	1	8
Signal recognition particle receptor subunit alpha	Homo sapiens (human)	Kd	30.0000	1	5
SNF-related serine/threonine-protein kinase	Homo sapiens (human)	Kd	10.0000	1	2
SRSF protein kinase 1	Homo sapiens (human)	Kd	10.0000	2	4
SRSF protein kinase 2	Homo sapiens (human)	Kd	10.0000	2	4
SRSF protein kinase 3	Homo sapiens (human)	Kd	9.1500	1	2
STE20-like serine/threonine-protein kinase	Homo sapiens (human)	Kd	19.5250	4	13
STE20-related kinase adapter protein alpha	Homo sapiens (human)	Kd	30.0000	1	7
STE20/SPS1-related proline-alanine-rich protein kinase	Homo sapiens (human)	Kd	10.0000	1	2
Structural maintenance of chromosomes protein 1A	Homo sapiens (human)	Kd	30.0000	1	6
Structural maintenance of chromosomes protein 2	Homo sapiens (human)	Kd	30.0000	1	7
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	7
Testis-specific serine/threonine-protein kinase 1	Homo sapiens (human)	Kd	10.0000	2	4
TGF-beta receptor type-1	Homo sapiens (human)	Kd	23.3333	3	12
TGF-beta receptor type-2	Homo sapiens (human)	Kd	22.0000	3	10
Thyroid hormone receptor-associated protein 3	Homo sapiens (human)	Kd	30.0000	1	5
TRAF2 and NCK-interacting protein kinase	Homo sapiens (human)	Kd	21.9455	3	11
Transient receptor potential cation channel subfamily M member 6	Homo sapiens (human)	Kd	10.0000	1	2
Tubulin alpha-1A chain	Rattus norvegicus (Norway rat)	Kd	0.3200	1	2
Tyrosine--tRNA ligase, cytoplasmic	Homo sapiens (human)	Kd	30.0000	1	7
Tyrosine-protein kinase ABL1	Homo sapiens (human)	Kd	4.9254	31	59
Tyrosine-protein kinase ABL2	Homo sapiens (human)	Kd	18.2480	4	13
Tyrosine-protein kinase Blk	Homo sapiens (human)	Kd	0.6950	2	4
Tyrosine-protein kinase BTK	Homo sapiens (human)	Kd	17.3207	3	11
Tyrosine-protein kinase CSK	Homo sapiens (human)	Kd	23.3000	3	12
Tyrosine-protein kinase Fer	Homo sapiens (human)	Kd	22.7273	3	11
Tyrosine-protein kinase Fes/Fps	Homo sapiens (human)	Kd	23.8462	3	13
Tyrosine-protein kinase Fgr	Homo sapiens (human)	Kd	12.4667	3	6
Tyrosine-protein kinase FRK	Homo sapiens (human)	Kd	19.8182	3	11
Tyrosine-protein kinase Fyn	Homo sapiens (human)	Kd	23.3333	3	12
Tyrosine-protein kinase HCK	Homo sapiens (human)	Kd	21.0333	3	12
Tyrosine-protein kinase ITK/TSK	Homo sapiens (human)	Kd	10.0000	2	4
Tyrosine-protein kinase JAK1	Homo sapiens (human)	Kd	20.7692	4	13
Tyrosine-protein kinase JAK2	Homo sapiens (human)	Kd	12.7400	3	5
Tyrosine-protein kinase JAK3	Homo sapiens (human)	Kd	5.4075	2	4
Tyrosine-protein kinase Lck	Homo sapiens (human)	Kd	15.2800	5	14
Tyrosine-protein kinase Lyn	Homo sapiens (human)	Kd	16.8654	3	11
Tyrosine-protein kinase Mer	Homo sapiens (human)	Kd	17.2829	3	7
Tyrosine-protein kinase receptor Tie-1	Homo sapiens (human)	Kd	5.4250	2	4
Tyrosine-protein kinase receptor TYRO3	Homo sapiens (human)	Kd	6.9500	2	4
Tyrosine-protein kinase receptor UFO	Homo sapiens (human)	Kd	6.4500	2	4
Tyrosine-protein kinase Srms	Homo sapiens (human)	Kd	10.0000	2	4
Tyrosine-protein kinase SYK	Homo sapiens (human)	Kd	23.3333	3	12
Tyrosine-protein kinase Tec	Homo sapiens (human)	Kd	17.3082	3	11
Tyrosine-protein kinase TXK	Homo sapiens (human)	Kd	6.4500	2	4
Tyrosine-protein kinase Yes	Homo sapiens (human)	Kd	20.1411	3	11
Tyrosine-protein kinase ZAP-70	Homo sapiens (human)	Kd	10.0000	2	4
U5 small nuclear ribonucleoprotein 200 kDa helicase	Homo sapiens (human)	Kd	30.0000	1	7
UMP-CMP kinase	Homo sapiens (human)	Kd	30.0000	1	3
Uncharacterized aarF domain-containing protein kinase 5	Homo sapiens (human)	Kd	30.0000	1	6
Uncharacterized protein FLJ45252	Homo sapiens (human)	Kd	30.0000	1	7
Uncharacterized serine/threonine-protein kinase SBK3	Homo sapiens (human)	Kd	10.0000	1	2
Vascular endothelial growth factor receptor 1	Homo sapiens (human)	Kd	7.2000	2	4
Vascular endothelial growth factor receptor 2	Homo sapiens (human)	Kd	8.9250	2	4
Vascular endothelial growth factor receptor 3	Homo sapiens (human)	Kd	6.0500	2	4
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	7
Wee1-like protein kinase	Homo sapiens (human)	Kd	25.9235	3	11
Wee1-like protein kinase 2	Homo sapiens (human)	Kd	10.0000	1	2

Other Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
Epidermal growth factor receptor	Homo sapiens (human)	DC50	2.0000	2	2