Compounds > usambarensine
Page last updated: 2024-08-01 10:02:57

usambarensine

Description

usambarensine: structure given in first source [MeSH]

Usambarensine : no description available [CHeBI]

Cross-References

ID SourceID
PubMed CID5281413
CHEMBL ID490322
SCHEMBL ID168639
CHEBI ID9910
MeSH IDM0192855

Synonyms (12)

Synonym
usambarensine
36150-14-8
C09249
chebi:9910 ,
CHEMBL490322 ,
17-norcorynan, 19,20-didehydro-16-(9h-pyrido(3,4-b)indol-1-yl)-, (19e)-
AC1NQYFE ,
(2r,3e,12bs)-3-ethylidene-2-(9h-pyrido[3,4-b]indol-1-ylmethyl)-2,4,6,7,12,12b-hexahydro-1h-indolo[2,3-a]quinolizine
SCHEMBL168639
surecn168639
Q27108512
DTXSID901317653

Drug Classes (1)

ClassDescription
harmala alkaloidAny member of a class of naturally occurring alkaloids based on a 1-methyl-9H-beta-carboline skeleton.

Bioassays (12)

Assay IDTitleYearJournalArticle
AID361155Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2/Indochina by [3H]hypoxanthine uptake2002Journal of natural products, Oct, Volume: 65, Issue:10
ISSN: 0163-3864		Antiplasmodial activity of alkaloids from various strychnos species.
AID361157Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum FCA 20/ Ghana by [3H]hypoxanthine uptake2002Journal of natural products, Oct, Volume: 65, Issue:10
ISSN: 0163-3864		Antiplasmodial activity of alkaloids from various strychnos species.
AID496819Antimicrobial activity against Plasmodium falciparum2010Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6
ISSN: 1464-3391		Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
AID358512Selectivity index, ratio of IC50 for human WI38 cells to IC50 for chloroquine-sensitive Plasmodium falciparum FCA 20 Ghana2001Journal of natural products, Jan, Volume: 64, Issue:1
ISSN: 0163-3864		Strychnogucines A and B, two new antiplasmodial bisindole alkaloids from Strychnos icaja.
AID358508Cytotoxicity against human KB cells by WST1 assay2001Journal of natural products, Jan, Volume: 64, Issue:1
ISSN: 0163-3864		Strychnogucines A and B, two new antiplasmodial bisindole alkaloids from Strychnos icaja.
AID361154Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FCB1-R/Colombia by [3H]hypoxanthine uptake2002Journal of natural products, Oct, Volume: 65, Issue:10
ISSN: 0163-3864		Antiplasmodial activity of alkaloids from various strychnos species.
AID358510Selectivity index, ratio of IC50 for human KB cells to IC50 for chloroquine-sensitive Plasmodium falciparum FCA 20 Ghana2001Journal of natural products, Jan, Volume: 64, Issue:1
ISSN: 0163-3864		Strychnogucines A and B, two new antiplasmodial bisindole alkaloids from Strychnos icaja.
AID379452Antiplasmodial activity after 36 hrs against chloroquine-resistant Plasmodium falciparum W2 in human erythrocytes by [3H]hypoxanthine uptake1999Journal of natural products, Apr, Volume: 62, Issue:4
ISSN: 0163-3864		10'-Hydroxyusambarensine, a new antimalarial bisindole alkaloid from the roots of Strychnos usambarensis.
AID358511Selectivity index, ratio of IC50 for human KB cells to IC50 for chloroquine-resistant Plasmodium falciparum W2 Indochina2001Journal of natural products, Jan, Volume: 64, Issue:1
ISSN: 0163-3864		Strychnogucines A and B, two new antiplasmodial bisindole alkaloids from Strychnos icaja.
AID379451Antiplasmodial activity after 36 hrs against chloroquine-sensitive Plasmodium falciparum FCA 20 in human erythrocytes by [3H]hypoxanthine uptake1999Journal of natural products, Apr, Volume: 62, Issue:4
ISSN: 0163-3864		10'-Hydroxyusambarensine, a new antimalarial bisindole alkaloid from the roots of Strychnos usambarensis.
AID358509Cytotoxicity against human WI38 cells by WST1 assay2001Journal of natural products, Jan, Volume: 64, Issue:1
ISSN: 0163-3864		Strychnogucines A and B, two new antiplasmodial bisindole alkaloids from Strychnos icaja.
AID358513Selectivity index, ratio of IC50 for human WI38 cells to IC50 for chloroquine-resistant Plasmodium falciparum W2 Indochina2001Journal of natural products, Jan, Volume: 64, Issue:1
ISSN: 0163-3864		Strychnogucines A and B, two new antiplasmodial bisindole alkaloids from Strychnos icaja.

Research

Studies (4)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (25.00)18.2507
2000's2 (50.00)29.6817
2010's1 (25.00)24.3611
2020's0 (0.00)2.80

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
harmaline
0
harmala alkaloidoneirogen00low000000
harmalol
0
harmala alkaloidalgal metabolite;
EC 1.4.3.4 (monoamine oxidase) inhibitor		00low000000
harmol
0
harmala alkaloid00low000000
1-methyl-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid
0
harmala alkaloid00low000000
harmalan
0
harmala alkaloid00low000000
TCMDC-138263
0
harmala alkaloid00low000000
1-acetyl-beta-carboline
0
harmala alkaloidmetabolite00low000000
1-(1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid
0
harmala alkaloid00low000000
1-[3-[[4-(4-fluorophenyl)-1-piperazinyl]methyl]-4-methoxyphenyl]-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid
0
harmala alkaloid00low000000
harmine
0
harmala alkaloidanti-HIV agent;
EC 1.4.3.4 (monoamine oxidase) inhibitor;
metabolite		00low000000
harman
0
harmala alkaloid;
indole alkaloid fundamental parent;
indole alkaloid		anti-HIV agent;
EC 1.4.3.4 (monoamine oxidase) inhibitor;
plant metabolite		00low000000
1-Ethyl-9H-pyrido[3,4-b]indole
0
harmala alkaloid00low000000
beta-carboline-1-propionic acid
0
harmala alkaloid00low000000
flazin
0
harmala alkaloidmetabolite00low000000
N-(2,3-dimethylphenyl)-1-methyl-9H-pyrido[3,4-b]indole-3-carboxamide
0
harmala alkaloid00low000000
brevicarine
0
harmala alkaloid00low000000
(3S)-2-(2-chloro-1-oxoethyl)-1,1-dimethyl-4,9-dihydro-3H-pyrido[3,4-b]indole-3-carboxylic acid methyl ester
0
harmala alkaloid00low000000
2-[(1-ethyl-3-methyl-4-pyrazolyl)methyl]-1-(4-fluoro-3-methoxyphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole
0
harmala alkaloid00low000000
[3-(1-methyl-2-pyrrolyl)-1H-pyrazol-5-yl]-[1-(2-pyridinyl)-1,3,4,9-tetrahydropyrido[3,4-b]indol-2-yl]methanone
0
harmala alkaloid00low000000
1-cyclohexyl-2-(1H-imidazol-2-ylmethyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole
0
harmala alkaloid00low000000
1-cyclohexyl-2-[(1-ethyl-2-imidazolyl)methyl]-1,3,4,9-tetrahydropyrido[3,4-b]indole
0
harmala alkaloid00low000000
5-[[1-(2-methoxyphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indol-2-yl]methyl]-2-methylthiazole
0
harmala alkaloid00low000000
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
quinacrine
1
acridines;
aromatic ether;
organochlorine compound;
tertiary amino compound		antimalarial;
EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor		2010201014.0low000100
aminooxyacetic acid
1
amino acid;
hydroxylamines;
monocarboxylic acid		anticonvulsant;
EC 2.6.1.19 (4-aminobutyrate--2-oxoglutarate transaminase) inhibitor;
EC 4.2.1.22 (cystathionine beta-synthase) inhibitor;
nootropic agent		2010201014.0low000100
aminocaproic acid
1
amino acid zwitterion;
epsilon-amino acid;
omega-amino fatty acid		antifibrinolytic drug;
hematologic agent;
metabolite		2010201014.0low000100
phenytoin
1
imidazolidine-2,4-dioneanticonvulsant;
drug allergen;
sodium channel blocker;
teratogenic agent		2010201014.0low000100
acebutolol
1
aromatic amide;
ethanolamines;
ether;
monocarboxylic acid amide;
propanolamine;
secondary amino compound		anti-arrhythmia drug;
antihypertensive agent;
beta-adrenergic antagonist;
sympathomimetic agent		2010201014.0low000100
acetaminophen
1
acetamides;
phenols		antipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
cyclooxygenase 3 inhibitor;
environmental contaminant;
ferroptosis inducer;
geroprotector;
hepatotoxic agent;
human blood serum metabolite;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
xenobiotic		2010201014.0low000100
acetazolamide
1
monocarboxylic acid amide;
sulfonamide;
thiadiazoles		anticonvulsant;
diuretic;
EC 4.2.1.1 (carbonic anhydrase) inhibitor		2010201014.0low000100
acetohydroxamic acid
1
acetohydroxamic acids;
carbohydroximic acid		algal metabolite;
EC 3.5.1.5 (urease) inhibitor		2010201014.0low000100
albuterol
1
phenols;
phenylethanolamines;
secondary amino compound		beta-adrenergic agonist;
bronchodilator agent;
environmental contaminant;
xenobiotic		2010201014.0low000100
alendronate
1
1,1-bis(phosphonic acid);
primary amino compound		bone density conservation agent;
EC 2.5.1.1 (dimethylallyltranstransferase) inhibitor		2010201014.0low000100
alprazolam
1
organochlorine compound;
triazolobenzodiazepine		anticonvulsant;
anxiolytic drug;
GABA agonist;
muscle relaxant;
sedative;
xenobiotic		2010201014.0low000100
aminoglutethimide
1
dicarboximide;
piperidones;
substituted aniline		adrenergic agent;
anticonvulsant;
antineoplastic agent;
EC 1.14.14.14 (aromatase) inhibitor		2010201014.0low000100
theophylline
1
dimethylxanthineadenosine receptor antagonist;
anti-asthmatic drug;
anti-inflammatory agent;
bronchodilator agent;
drug metabolite;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
fungal metabolite;
human blood serum metabolite;
immunomodulator;
muscle relaxant;
vasodilator agent		2010201014.0low000100
amiodarone
1
1-benzofurans;
aromatic ketone;
organoiodine compound;
tertiary amino compound		cardiovascular drug2010201014.0low000100
amitriptyline
1
carbotricyclic compound;
tertiary amine		adrenergic uptake inhibitor;
antidepressant;
environmental contaminant;
tropomyosin-related kinase B receptor agonist;
xenobiotic		2010201014.0low000100
amlodipine
1
dihydropyridine;
ethyl ester;
methyl ester;
monochlorobenzenes;
primary amino compound		antihypertensive agent;
calcium channel blocker;
vasodilator agent		2010201014.0low000100
aprindine
1
indanes2010201014.0low000100
aspirin
1
benzoic acids;
phenyl acetates;
salicylates		anticoagulant;
antipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
drug allergen;
EC 1.1.1.188 (prostaglandin-F synthase) inhibitor;
geroprotector;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
plant activator;
platelet aggregation inhibitor;
prostaglandin antagonist;
teratogenic agent		2010201014.0low000100
atenolol
1
ethanolamines;
monocarboxylic acid amide;
propanolamine		anti-arrhythmia drug;
antihypertensive agent;
beta-adrenergic antagonist;
environmental contaminant;
sympatholytic agent;
xenobiotic		2010201014.0low000100
azathioprine
1
aryl sulfide;
C-nitro compound;
imidazoles;
thiopurine		antimetabolite;
antineoplastic agent;
carcinogenic agent;
DNA synthesis inhibitor;
hepatotoxic agent;
immunosuppressive agent;
prodrug		2010201014.0low000100
bepridil
1
pyrrolidines;
tertiary amine		anti-arrhythmia drug;
antihypertensive agent;
calcium channel blocker;
vasodilator agent		2010201014.0low000100
bisoprolol
1
secondary alcohol;
secondary amine		anti-arrhythmia drug;
antihypertensive agent;
beta-adrenergic antagonist;
sympatholytic agent		2010201014.0low000100
bretylium
1
quaternary ammonium ionadrenergic antagonist;
anti-arrhythmia drug;
antihypertensive agent		2010201014.0low000100
bromhexine
1
organobromine compound;
substituted aniline;
tertiary amino compound		mucolytic2010201014.0low000100
bumetanide
1
amino acid;
benzoic acids;
sulfonamide		diuretic;
EC 3.6.3.49 (channel-conductance-controlling ATPase) inhibitor		2010201014.0low000100
verapamil
1
aromatic ether;
nitrile;
polyether;
tertiary amino compound		2010201014.0low000100
carbamazepine
1
dibenzoazepine;
ureas		analgesic;
anticonvulsant;
antimanic drug;
drug allergen;
EC 3.5.1.98 (histone deacetylase) inhibitor;
environmental contaminant;
glutamate transporter activator;
mitogen;
non-narcotic analgesic;
sodium channel blocker;
xenobiotic		2010201014.0low000100
carmustine
1
N-nitrosoureas;
organochlorine compound		alkylating agent;
antineoplastic agent		2010201014.0low000100
carteolol
1
quinolone;
secondary alcohol		anti-arrhythmia drug;
antiglaucoma drug;
antihypertensive agent;
beta-adrenergic antagonist;
sympatholytic agent		2010201014.0low000100
chlordiazepoxide
1
benzodiazepine2010201014.0low000100
chloroquine
3
aminoquinoline;
organochlorine compound;
secondary amino compound;
tertiary amino compound		anticoronaviral agent;
antimalarial;
antirheumatic drug;
autophagy inhibitor;
dermatologic drug		2001201019.7low000300
chlorpromazine
1
organochlorine compound;
phenothiazines;
tertiary amine		anticoronaviral agent;
antiemetic;
dopaminergic antagonist;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
phenothiazine antipsychotic drug		2010201014.0low000100
chlorpropamide
1
monochlorobenzenes;
N-sulfonylurea		hypoglycemic agent;
insulin secretagogue		2010201014.0low000100
chlorthalidone
1
isoindoles;
monochlorobenzenes;
sulfonamide		2010201014.0low000100
cimetidine
1
aliphatic sulfide;
guanidines;
imidazoles;
nitrile		adjuvant;
analgesic;
anti-ulcer drug;
H2-receptor antagonist;
P450 inhibitor		2010201014.0low000100
citalopram
1
2-benzofurans;
cyclic ether;
nitrile;
organofluorine compound;
tertiary amino compound		2010201014.0low000100
clenbuterol
1
amino alcohol;
dichlorobenzene;
ethanolamines;
primary arylamine;
secondary amino compound;
substituted aniline		beta-adrenergic agonist;
bronchodilator agent;
sympathomimetic agent		2010201014.0low000100
clioquinol
1
monohydroxyquinoline;
organochlorine compound;
organoiodine compound		antibacterial agent;
antifungal agent;
antimicrobial agent;
antineoplastic agent;
antiprotozoal drug;
chelator;
copper chelator		2010201014.0low000100
clofibrate
1
aromatic ether;
ethyl ester;
monochlorobenzenes		anticholesteremic drug;
antilipemic drug;
geroprotector;
PPARalpha agonist		2010201014.0low000100
clomipramine
1
dibenzoazepineanticoronaviral agent;
antidepressant;
EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor;
serotonergic antagonist;
serotonergic drug;
serotonin uptake inhibitor		2010201014.0low000100
clonidine
1
clonidine;
imidazoline		2010201014.0low000100
chlorazepate
1
1,4-benzodiazepinoneanticonvulsant;
anxiolytic drug;
GABA modulator;
prodrug		2010201014.0medium000100
dapsone
1
substituted aniline;
sulfone		anti-inflammatory drug;
antiinfective agent;
antimalarial;
leprostatic drug		2010201014.0low000100
debrisoquin
1
carboxamidine;
isoquinolines		adrenergic agent;
antihypertensive agent;
human metabolite;
sympatholytic agent		2010201014.0low000100
desipramine
1
dibenzoazepine;
secondary amino compound		adrenergic uptake inhibitor;
alpha-adrenergic antagonist;
antidepressant;
cholinergic antagonist;
drug allergen;
EC 3.1.4.12 (sphingomyelin phosphodiesterase) inhibitor;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
H1-receptor antagonist;
serotonin uptake inhibitor		2010201014.0low000100
diazepam
1
1,4-benzodiazepinone;
organochlorine compound		anticonvulsant;
anxiolytic drug;
environmental contaminant;
sedative;
xenobiotic		2010201014.0low000100
diazoxide
1
benzothiadiazine;
organochlorine compound;
sulfone		antihypertensive agent;
beta-adrenergic agonist;
bronchodilator agent;
cardiotonic drug;
diuretic;
K-ATP channel agonist;
sodium channel blocker;
sympathomimetic agent;
vasodilator agent		2010201014.0low000100
diclofenac
1
amino acid;
aromatic amine;
dichlorobenzene;
monocarboxylic acid;
secondary amino compound		antipyretic;
drug allergen;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
xenobiotic		2010201014.0low000100
3,4-dihydroxybenzohydroxamic acid
1
benzoic acids2010201014.0low000100
diflunisal
1
monohydroxybenzoic acid;
organofluorine compound		non-narcotic analgesic;
non-steroidal anti-inflammatory drug		2010201014.0low000100
dimercaprol
1
dithiol;
primary alcohol		chelator2010201014.0low000100
domperidone
1
benzimidazoles;
heteroarylpiperidine		antiemetic;
dopaminergic antagonist		2010201014.0low000100
ethacrynic acid
1
aromatic ether;
aromatic ketone;
dichlorobenzene;
monocarboxylic acid		EC 2.5.1.18 (glutathione transferase) inhibitor;
ion transport inhibitor;
loop diuretic		2010201014.0low000100
ethosuximide
1
dicarboximide;
pyrrolidinone		anticonvulsant;
geroprotector;
T-type calcium channel blocker		2010201014.0low000100
ethyl loflazepate
1
organic molecular entity2010201014.0low000100
felodipine
1
dichlorobenzene;
dihydropyridine;
ethyl ester;
methyl ester		anti-arrhythmia drug;
antihypertensive agent;
calcium channel blocker;
vasodilator agent		2010201014.0low000100
berotek
1
resorcinols;
secondary alcohol;
secondary amino compound		beta-adrenergic agonist;
bronchodilator agent;
sympathomimetic agent;
tocolytic agent		2010201014.0low000100
fentanyl
1
anilide;
monocarboxylic acid amide;
piperidines		adjuvant;
anaesthesia adjuvant;
anaesthetic;
intravenous anaesthetic;
mu-opioid receptor agonist;
opioid analgesic		2010201014.0low000100
flecainide
1
aromatic ether;
monocarboxylic acid amide;
organofluorine compound;
piperidines		anti-arrhythmia drug2010201014.0low000100
fluphenazine
1
N-alkylpiperazine;
organofluorine compound;
phenothiazines		anticoronaviral agent;
dopaminergic antagonist;
phenothiazine antipsychotic drug		2010201014.0low000100
fluoxetine
1
(trifluoromethyl)benzenes;
aromatic ether;
secondary amino compound		2010201014.0low000100
flurbiprofen
1
fluorobiphenyl;
monocarboxylic acid		antipyretic;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug		2010201014.0low000100
flutamide
1
(trifluoromethyl)benzenes;
monocarboxylic acid amide		androgen antagonist;
antineoplastic agent		2010201014.0low000100
furosemide
1
chlorobenzoic acid;
furans;
sulfonamide		environmental contaminant;
loop diuretic;
xenobiotic		2010201014.0low000100
glutethimide
1
piperidines2010201014.0low000100
guanethidine
1
azocanes;
guanidines		adrenergic antagonist;
antihypertensive agent;
sympatholytic agent		2010201014.0low000100
hydrochlorothiazide
1
benzothiadiazine;
organochlorine compound;
sulfonamide		antihypertensive agent;
diuretic;
environmental contaminant;
xenobiotic		2010201014.0low000100
hydroxyurea
1
one-carbon compound;
ureas		antimetabolite;
antimitotic;
antineoplastic agent;
DNA synthesis inhibitor;
EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor;
genotoxin;
immunomodulator;
radical scavenger;
teratogenic agent		2010201014.0low000100
hydroxyzine
1
hydroxyether;
monochlorobenzenes;
N-alkylpiperazine		anticoronaviral agent;
antipruritic drug;
anxiolytic drug;
dermatologic drug;
H1-receptor antagonist		2010201014.0low000100
ibuprofen
1
monocarboxylic acidantipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
drug allergen;
environmental contaminant;
geroprotector;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
radical scavenger;
xenobiotic		2010201014.0low000100
phenelzine
1
primary amine2010201014.0low000100
lidocaine
1
benzenes;
monocarboxylic acid amide;
tertiary amino compound		anti-arrhythmia drug;
drug allergen;
environmental contaminant;
local anaesthetic;
xenobiotic		2010201014.0low000100
imipramine
1
dibenzoazepineadrenergic uptake inhibitor;
antidepressant;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor		2010201014.0low000100
amrinone
1
bipyridinesEC 3.1.4.* (phosphoric diester hydrolase) inhibitor2010201014.0low000100
incadronate
1
1,1-bis(phosphonic acid)2010201014.0low000100
indapamide
1
indoles;
organochlorine compound;
sulfonamide		antihypertensive agent;
diuretic		2010201014.0low000100
indomethacin
1
aromatic ether;
indole-3-acetic acids;
monochlorobenzenes;
N-acylindole		analgesic;
drug metabolite;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
gout suppressant;
non-steroidal anti-inflammatory drug;
xenobiotic metabolite;
xenobiotic		2010201014.0low000100
nsc 664704
1
indolobenzazepine;
lactam;
organobromine compound		cardioprotective agent;
EC 2.7.11.22 (cyclin-dependent kinase) inhibitor;
EC 2.7.11.26 (tau-protein kinase) inhibitor;
geroprotector		2010201014.0low000100
ketamine
1
cyclohexanones;
monochlorobenzenes;
secondary amino compound		analgesic;
environmental contaminant;
intravenous anaesthetic;
neurotoxin;
NMDA receptor antagonist;
xenobiotic		2010201014.0low000100
ketanserin
1
aromatic ketone;
organofluorine compound;
piperidines;
quinazolines		alpha-adrenergic antagonist;
antihypertensive agent;
cardiovascular drug;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
serotonergic antagonist		2010201014.0low000100
ketoconazole
1
dichlorobenzene;
dioxolane;
ether;
imidazoles;
N-acylpiperazine;
N-arylpiperazine		2010201014.0low000100
ketoprofen
1
benzophenones;
oxo monocarboxylic acid		antipyretic;
drug allergen;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
non-steroidal anti-inflammatory drug;
xenobiotic		2010201014.0low000100
ketotifen
1
cyclic ketone;
olefinic compound;
organic heterotricyclic compound;
organosulfur heterocyclic compound;
piperidines;
tertiary amino compound		anti-asthmatic drug;
H1-receptor antagonist		2010201014.0low000100
labetalol
1
benzamides;
benzenes;
phenols;
primary carboxamide;
salicylamides;
secondary alcohol;
secondary amino compound		2010201014.0low000100
lansoprazole
1
benzimidazoles;
pyridines;
sulfoxide		anti-ulcer drug;
EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor		2010201014.0low000100
lofepramine
1
aromatic ketone;
dibenzoazepine;
monochlorobenzenes;
tertiary amino compound		antidepressant2010201014.0low000100
lomustine
1
N-nitrosoureas;
organochlorine compound		alkylating agent;
antineoplastic agent		2010201014.0low000100
lorazepam
1
benzodiazepine2010201014.0low000100
maprotiline
1
anthracenes2010201014.0low000100
mazindol
1
organic molecular entity2010201014.0low000100
mechlorethamine
1
nitrogen mustard;
organochlorine compound		alkylating agent2010201014.0low000100
mefloquine hydrochloride
2
organofluorine compound;
piperidines;
quinolines;
secondary alcohol		2001201018.5low000200
mephenytoin
1
imidazolidine-2,4-dioneanticonvulsant2010201014.0low000100
methoxyamine
1
organooxygen compound2010201014.0low000100
methoxyflurane
1
ether;
organochlorine compound;
organofluorine compound		hepatotoxic agent;
inhalation anaesthetic;
nephrotoxic agent;
non-narcotic analgesic		2010201014.0low000100
methylphenidate
1
beta-amino acid ester;
methyl ester;
piperidines		2010201014.0low000100
metoclopramide
1
benzamides;
monochlorobenzenes;
substituted aniline;
tertiary amino compound		antiemetic;
dopaminergic antagonist;
environmental contaminant;
gastrointestinal drug;
xenobiotic		2010201014.0low000100
metronidazole
1
C-nitro compound;
imidazoles;
primary alcohol		antiamoebic agent;
antibacterial drug;
antimicrobial agent;
antiparasitic agent;
antitrichomonal drug;
environmental contaminant;
prodrug;
radiosensitizing agent;
xenobiotic		2010201014.0low000100
mexiletine
1
aromatic ether;
primary amino compound		anti-arrhythmia drug2010201014.0low000100
mianserin
1
dibenzoazepineadrenergic uptake inhibitor;
alpha-adrenergic antagonist;
antidepressant;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
geroprotector;
H1-receptor antagonist;
histamine agonist;
sedative;
serotonergic antagonist		2010201014.0low000100
minoxidil
1
dialkylarylamine;
tertiary amino compound		2010201014.0low000100
nabumetone
1
methoxynaphthalene;
methyl ketone		cyclooxygenase 2 inhibitor;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
prodrug		2010201014.0low000100
nifedipine
1
C-nitro compound;
dihydropyridine;
methyl ester		calcium channel blocker;
human metabolite;
tocolytic agent;
vasodilator agent		2010201014.0low000100
nitrendipine
1
C-nitro compound;
dicarboxylic acids and O-substituted derivatives;
diester;
dihydropyridine;
ethyl ester;
methyl ester		antihypertensive agent;
calcium channel blocker;
geroprotector;
vasodilator agent		2010201014.0low000100
nitroglycerin
1
nitroglycerolexplosive;
muscle relaxant;
nitric oxide donor;
prodrug;
tocolytic agent;
vasodilator agent;
xenobiotic		2010201014.0low000100
nomifensine
1
isoquinolinesdopamine uptake inhibitor2010201014.0low000100
norfloxacin
1
fluoroquinolone antibiotic;
N-arylpiperazine;
quinolinemonocarboxylic acid;
quinolone antibiotic;
quinolone		antibacterial drug;
DNA synthesis inhibitor;
environmental contaminant;
xenobiotic		2010201014.0low000100
nortriptyline
1
organic tricyclic compound;
secondary amine		adrenergic uptake inhibitor;
analgesic;
antidepressant;
antineoplastic agent;
apoptosis inducer;
drug metabolite		2010201014.0low000100
olomoucine
1
2,6-diaminopurines;
ethanolamines		EC 2.7.11.22 (cyclin-dependent kinase) inhibitor2010201014.0low000100
omeprazole
1
aromatic ether;
benzimidazoles;
pyridines;
sulfoxide		2010201014.0low000100
oxatomide
1
benzimidazoles;
diarylmethane;
N-alkylpiperazine		anti-allergic agent;
anti-inflammatory agent;
geroprotector;
H1-receptor antagonist;
serotonergic antagonist		2010201014.0low000100
oxazepam
1
1,4-benzodiazepinone;
organochlorine compound		anxiolytic drug;
environmental contaminant;
xenobiotic		2010201014.0low000100
oxprenolol
1
aromatic ether2010201014.0low000100
oxyphenbutazone
1
phenols;
pyrazolidines		antimicrobial agent;
antineoplastic agent;
antipyretic;
drug metabolite;
gout suppressant;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
xenobiotic metabolite		2010201014.0low000100
aminosalicylic acid
1
aminobenzoic acid;
phenols		antitubercular agent2010201014.0low000100
pamidronate
1
phosphonoacetic acid2010201014.0low000100
pantoprazole
1
aromatic ether;
benzimidazoles;
organofluorine compound;
pyridines;
sulfoxide		anti-ulcer drug;
EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor;
environmental contaminant;
xenobiotic		2010201014.0low000100
papaverine
1
benzylisoquinoline alkaloid;
dimethoxybenzene;
isoquinolines		antispasmodic drug;
vasodilator agent		2010201014.0low000100
pentamidine
1
aromatic ether;
carboxamidine;
diether		anti-inflammatory agent;
antifungal agent;
calmodulin antagonist;
chemokine receptor 5 antagonist;
EC 2.3.1.48 (histone acetyltransferase) inhibitor;
NMDA receptor antagonist;
S100 calcium-binding protein B inhibitor;
trypanocidal drug;
xenobiotic		2010201014.0low000100
perphenazine
1
N-(2-hydroxyethyl)piperazine;
N-alkylpiperazine;
organochlorine compound;
phenothiazines		antiemetic;
dopaminergic antagonist;
phenothiazine antipsychotic drug		2010201014.0low000100
phenacetin
1
acetamides;
aromatic ether		cyclooxygenase 3 inhibitor;
non-narcotic analgesic;
peripheral nervous system drug		2010201014.0low000100
phenindione
1
aromatic ketone;
beta-diketone		anticoagulant2010201014.0low000100
phentermine
1
primary amineadrenergic agent;
appetite depressant;
central nervous system drug;
central nervous system stimulant;
dopaminergic agent;
sympathomimetic agent		2010201014.0low000100
phenylbutazone
1
pyrazolidinesantirheumatic drug;
EC 1.1.1.184 [carbonyl reductase (NADPH)] inhibitor;
metabolite;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
peripheral nervous system drug		2010201014.0low000100
primaquine
1
aminoquinoline;
aromatic ether;
N-substituted diamine		antimalarial2010201014.0low000100
procainamide
1
benzamidesanti-arrhythmia drug;
platelet aggregation inhibitor;
sodium channel blocker		2010201014.0low000100
procaine
1
benzoate ester;
substituted aniline;
tertiary amino compound		central nervous system depressant;
drug allergen;
local anaesthetic;
peripheral nervous system drug		2010201014.0low000100
procarbazine
1
benzamides;
hydrazines		antineoplastic agent2010201014.0low000100
promethazine
1
phenothiazines;
tertiary amine		anti-allergic agent;
anticoronaviral agent;
antiemetic;
antipruritic drug;
H1-receptor antagonist;
local anaesthetic;
sedative		2010201014.0low000100
propranolol
1
naphthalenes;
propanolamine;
secondary amine		anti-arrhythmia drug;
antihypertensive agent;
anxiolytic drug;
beta-adrenergic antagonist;
environmental contaminant;
human blood serum metabolite;
vasodilator agent;
xenobiotic		2010201014.0low000100
pyrimethamine
1
aminopyrimidine;
monochlorobenzenes		antimalarial;
antiprotozoal drug;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor		2010201014.0low000100
rabeprazole
1
benzimidazoles;
pyridines;
sulfoxide		anti-ulcer drug;
EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor		2010201014.0low000100
ranitidine
1
aralkylamine2010201014.0low000100
risedronic acid
1
pyridines2010201014.0low000100
sulforaphane
1
isothiocyanate;
sulfoxide		antineoplastic agent;
antioxidant;
EC 3.5.1.98 (histone deacetylase) inhibitor;
plant metabolite		2010201014.0low000100
terbutaline
1
phenylethanolamines;
resorcinols		anti-asthmatic drug;
beta-adrenergic agonist;
bronchodilator agent;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
hypoglycemic agent;
sympathomimetic agent;
tocolytic agent		2010201014.0low000100
terfenadine
1
diarylmethane2010201014.0low000100
thioridazine
1
phenothiazines;
piperidines		alpha-adrenergic antagonist;
dopaminergic antagonist;
EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
first generation antipsychotic;
H1-receptor antagonist;
serotonergic antagonist		2010201014.0low000100
ticlopidine
1
monochlorobenzenes;
thienopyridine		anticoagulant;
fibrin modulating drug;
hematologic agent;
P2Y12 receptor antagonist;
platelet aggregation inhibitor		2010201014.0low000100
tolbutamide
1
N-sulfonylureahuman metabolite;
hypoglycemic agent;
insulin secretagogue;
potassium channel blocker		2010201014.0low000100
triamterene
1
pteridinesdiuretic;
sodium channel blocker		2010201014.0low000100
triazolam
1
triazolobenzodiazepinesedative2010201014.0low000100
trifluoperazine
1
N-alkylpiperazine;
N-methylpiperazine;
organofluorine compound;
phenothiazines		antiemetic;
calmodulin antagonist;
dopaminergic antagonist;
EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor;
EC 5.3.3.5 (cholestenol Delta-isomerase) inhibitor;
phenothiazine antipsychotic drug		2010201014.0low000100
trimethadione
1
oxazolidinoneanticonvulsant;
geroprotector		2010201014.0low000100
trimethoprim
1
aminopyrimidine;
methoxybenzenes		antibacterial drug;
diuretic;
drug allergen;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor;
environmental contaminant;
xenobiotic		2010201014.0low000100
zopiclone
1
monochloropyridine;
pyrrolopyrazine		central nervous system depressant;
sedative		2010201014.0low000100
reserpine
1
alkaloid ester;
methyl ester;
yohimban alkaloid		adrenergic uptake inhibitor;
antihypertensive agent;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
environmental contaminant;
first generation antipsychotic;
plant metabolite;
xenobiotic		2010201014.0low000100
paramethasone
1
fluorinated steroid2010201014.0low000100
cetrimonium bromide
1
organic bromide salt;
quaternary ammonium salt		detergent;
surfactant		2010201014.0low000100
levodopa
1
amino acid zwitterion;
dopa;
L-tyrosine derivative;
non-proteinogenic L-alpha-amino acid		allelochemical;
antidyskinesia agent;
antiparkinson drug;
dopaminergic agent;
hapten;
human metabolite;
mouse metabolite;
neurotoxin;
plant growth retardant;
plant metabolite;
prodrug		2010201014.0low000100
fluocinolone acetonide
1
11beta-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(1),Delta(4)-steroid;
cyclic ketal;
fluorinated steroid;
glucocorticoid;
organic heteropentacyclic compound;
primary alpha-hydroxy ketone		anti-inflammatory drug;
antipruritic drug		2010201014.0low000100
mannitol
1
mannitolallergen;
antiglaucoma drug;
compatible osmolytes;
Escherichia coli metabolite;
food anticaking agent;
food bulking agent;
food humectant;
food stabiliser;
food thickening agent;
hapten;
metabolite;
osmotic diuretic;
sweetening agent		2010201014.0low000100
cytarabine
1
beta-D-arabinoside;
monosaccharide derivative;
pyrimidine nucleoside		antimetabolite;
antineoplastic agent;
antiviral agent;
immunosuppressive agent		2010201014.0low000100
sulfobromophthalein sodium
1
organic sodium saltdye2010201014.0low000100
ethane
1
alkane;
gas molecular entity		plant metabolite;
refrigerant		2002200222.0low000100
methylprednisolone
1
6-methylprednisolone;
primary alpha-hydroxy ketone;
tertiary alpha-hydroxy ketone		adrenergic agent;
anti-inflammatory drug;
antiemetic;
environmental contaminant;
neuroprotective agent;
xenobiotic		2010201014.0low000100
pseudoephedrine
1
phenylethanolamines;
secondary alcohol;
secondary amino compound		anti-asthmatic drug;
bronchodilator agent;
central nervous system drug;
nasal decongestant;
plant metabolite;
sympathomimetic agent;
vasoconstrictor agent;
xenobiotic		2010201014.0low000100
phenformin
1
biguanidesantineoplastic agent;
geroprotector;
hypoglycemic agent		2010201014.0low000100
sterogenol
1
bromide salt;
pyridinium salt		antiseptic drug;
EC 2.7.11.18 (myosin-light-chain kinase) inhibitor;
surfactant		2010201014.0low000100
cycloguanil
1
triazinesantifolate;
antiinfective agent;
antimalarial;
antiparasitic agent;
antiprotozoal drug;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor		2010201014.0low000100
betamethasone
1
11beta-hydroxy steroid;
17alpha-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(1),Delta(4)-steroid;
fluorinated steroid;
glucocorticoid;
primary alpha-hydroxy ketone;
tertiary alpha-hydroxy ketone		anti-asthmatic agent;
anti-inflammatory drug;
immunosuppressive agent		2010201014.0low000100
dextropropoxyphene
1
1-benzyl-3-(dimethylamino)-2-methyl-1-phenylpropyl propanoatemu-opioid receptor agonist;
opioid analgesic		2010201014.0low000100
emetine
2
isoquinoline alkaloid;
pyridoisoquinoline		antiamoebic agent;
anticoronaviral agent;
antiinfective agent;
antimalarial;
antineoplastic agent;
antiprotozoal drug;
antiviral agent;
autophagy inhibitor;
emetic;
expectorant;
plant metabolite;
protein synthesis inhibitor		2001201018.5low000200
benzohydroxamic acid
1
2010201014.0low000100
medroxyprogesterone
1
17alpha-hydroxy steroid;
20-oxo steroid;
3-oxo-Delta(4) steroid;
tertiary alpha-hydroxy ketone		contraceptive drug;
progestin;
synthetic oral contraceptive		2010201014.0low000100
megestrol acetate
1
20-oxo steroid;
3-oxo-Delta(4) steroid;
acetate ester;
steroid ester		antineoplastic agent;
appetite enhancer;
contraceptive drug;
progestin;
synthetic oral contraceptive		2010201014.0low000100
erythromycin
1
cyclic ketone;
erythromycin		2010201014.0low000100
sulfadoxine
1
pyrimidines;
sulfonamide		antibacterial drug;
antimalarial		2010201014.0low000100
acetophenazine
1
N-(2-hydroxyethyl)piperazine;
N-alkylpiperazine;
phenothiazines		phenothiazine antipsychotic drug2010201014.0low000100
beclomethasone
1
11beta-hydroxy steroid;
17alpha-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(1),Delta(4)-steroid;
chlorinated steroid;
corticosteroid;
glucocorticoid;
primary alpha-hydroxy ketone;
tertiary alpha-hydroxy ketone		anti-asthmatic drug;
anti-inflammatory drug		2010201014.0low000100
pyrodifenium bromide
1
organic molecular entity2010201014.0low000100
amopyroquine
1
2010201014.0low000100
xipamide
1
benzamides2010201014.0low000100
levamisole
1
6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazoleantinematodal drug;
antirheumatic drug;
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
immunological adjuvant;
immunomodulator		2010201014.0low000100
danazol
1
17beta-hydroxy steroid;
terminal acetylenic compound		anti-estrogen;
estrogen antagonist;
geroprotector		2010201014.0low000100
bromocriptine
1
indole alkaloidantidyskinesia agent;
antiparkinson drug;
dopamine agonist;
hormone antagonist		2010201014.0low000100
triamcinolone
1
11beta-hydroxy steroid;
16alpha-hydroxy steroid;
17alpha-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
C21-steroid hormone;
fluorinated steroid;
glucocorticoid;
primary alpha-hydroxy ketone;
tertiary alpha-hydroxy ketone		anti-allergic agent;
anti-inflammatory drug		2010201014.0low000100
benzonidazole
1
C-nitro compound;
imidazoles;
monocarboxylic acid amide		antiprotozoal drug2010201014.0low000100
halazepam
1
organic molecular entity2010201014.0low000100
dexchlorpheniramine
1
chlorphenamine2010201014.0low000100
timolol
1
timololanti-arrhythmia drug;
antiglaucoma drug;
antihypertensive agent;
beta-adrenergic antagonist		2010201014.0low000100
amineptin
1
amino acid;
carbocyclic fatty acid;
carbotricyclic compound;
secondary amino compound		antidepressant;
dopamine uptake inhibitor		2010201014.0low000100
etoposide
1
beta-D-glucoside;
furonaphthodioxole;
organic heterotetracyclic compound		antineoplastic agent;
DNA synthesis inhibitor		2010201014.0low000100
halofantrine
1
phenanthrenes2010201014.0low000100
hydroxymaprotilin
1
2010201014.0low000100
methyldopa
1
L-tyrosine derivative;
non-proteinogenic L-alpha-amino acid		alpha-adrenergic agonist;
antihypertensive agent;
hapten;
peripheral nervous system drug;
sympatholytic agent		2010201014.0low000100
tocainide
1
monocarboxylic acid amideanti-arrhythmia drug;
local anaesthetic;
sodium channel blocker		2010201014.0low000100
sq-11725
1
2010201014.0low000100
diltiazem
1
5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetateantihypertensive agent;
calcium channel blocker;
vasodilator agent		2010201014.0low000100
pinazepam
1
benzodiazepine2010201014.0low000100
butibufen
1
monoterpenoid2010201014.0low000100
paroxetine
1
aromatic ether;
benzodioxoles;
organofluorine compound;
piperidines		antidepressant;
anxiolytic drug;
hepatotoxic agent;
P450 inhibitor;
serotonin uptake inhibitor		2010201014.0low000100
captopril
1
alkanethiol;
L-proline derivative;
N-acylpyrrolidine;
pyrrolidinemonocarboxylic acid		antihypertensive agent;
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor		2010201014.0low000100
staurosporine
1
indolocarbazole alkaloid;
organic heterooctacyclic compound		apoptosis inducer;
bacterial metabolite;
EC 2.7.11.13 (protein kinase C) inhibitor;
geroprotector		2010201014.0low000100
alfentanil
1
monocarboxylic acid amide;
piperidines		central nervous system depressant;
intravenous anaesthetic;
mu-opioid receptor agonist;
opioid analgesic;
peripheral nervous system drug		2010201014.0low000100
piritrexim
1
2010201014.0low000100
bambuterol
1
carbamate ester;
phenylethanolamines		anti-asthmatic drug;
beta-adrenergic agonist;
bronchodilator agent;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
prodrug;
sympathomimetic agent;
tocolytic agent		2010201014.0low000100
salmeterol xinafoate
1
naphthoic acid2010201014.0low000100
ibandronic acid
1
2010201014.0low000100
trovafloxacin
1
2010201014.0low000100
chloroquine diphosphate
1
1999199925.0low001000
ursolic acid
1
hydroxy monocarboxylic acid;
pentacyclic triterpenoid		geroprotector;
plant metabolite		2010201014.0low000100
propamidine
1
aromatic ether;
guanidines;
polyether		antimicrobial agent;
antiseptic drug		2010201014.0low000100
sinefungin
1
adenosines;
non-proteinogenic alpha-amino acid		antifungal agent;
antimicrobial agent		2010201014.0low000100
droxicam
1
organic heterotricyclic compound;
pyridines		cyclooxygenase 1 inhibitor;
hepatotoxic agent;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
platelet aggregation inhibitor;
prodrug		2010201014.0low000100
etofibrate
1
monocarboxylic acid2010201014.0low000100
dexfenfluramine
1
fenfluramineappetite depressant;
serotonergic agonist;
serotonin uptake inhibitor		2010201014.0low000100
synthalin a
1
guanidineshepatotoxic agent;
hypoglycemic agent;
nephrotoxin		2010201014.0low000100
ibopamine
1
benzoate ester;
phenols		2010201014.0low000100
zoledronic acid
1
1,1-bis(phosphonic acid);
imidazoles		bone density conservation agent2010201014.0low000100
pirlindole
1
carbazoles2010201014.0low000100
artemether
1
artemisinin derivative;
cyclic acetal;
organic peroxide;
semisynthetic derivative;
sesquiterpenoid		antimalarial2010201014.0low000100
6-amino-1-hydroxyhexane-1,1-diphosphonate
1
1,1-bis(phosphonic acid)2010201014.0low000100
rexigen
1
2010201014.0low000100
aceclofenac
1
amino acid;
carboxylic ester;
dichlorobenzene;
monocarboxylic acid;
secondary amino compound		EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug		2010201014.0low000100
clociguanil
1
2010201014.0medium000100
tebuquine
1
2010201014.0low000100
atovaquone
1
hydroxy-1,2-naphthoquinone2010201014.0low000100
cryptolepine
1
indole alkaloid;
organic heterotetracyclic compound;
organonitrogen heterocyclic compound		anti-inflammatory agent;
antimalarial;
antineoplastic agent;
cysteine protease inhibitor;
plant metabolite		2010201014.0low000100
cinchonine
1
(8xi)-cinchonan-9-ol;
cinchona alkaloid		metabolite2010201014.0low000100
n-hexadecyl-n,n-dimethyl-3-ammonio-1-propanesulfonate
1
2010201014.0low000100
desethylchloroquine
1
aminoquinoline2010201014.0low000100
wr 159412
1
2010201014.0low000100
cinchonidine
1
(8xi)-cinchonan-9-ol;
cinchona alkaloid		metabolite2010201014.0low000100
benzyloxyamine
1
2010201014.0low000100
pyronaridine
1
aminoquinoline2010201014.0low000100
tafenoquine
1
(trifluoromethyl)benzenes;
aminoquinoline;
aromatic ether;
primary amino compound;
secondary amino compound		2010201014.0low000100
desethylamodiaquine
1
2010201014.0low000100
n,n-dideethylchloroquine
1
2010201014.0low000100
3,6-diamino-9-(4-(methylsulfonyl)aminophenyl)aminoacridine
1
2010201014.0medium000100
ne 58051
1
2010201014.0low000100
wr 242511
1
2010201014.0low000100
naproxen
1
methoxynaphthalene;
monocarboxylic acid		antipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
drug allergen;
environmental contaminant;
gout suppressant;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
xenobiotic		2010201014.0low000100
cyc 202
1
2,6-diaminopurinesantiviral drug;
EC 2.7.11.22 (cyclin-dependent kinase) inhibitor		2010201014.0low000100
atropine
1
2010201014.0low000100
deflazacort
1
corticosteroid hormone2010201014.0low000100
olpadronic acid
1
2010201014.0low000100
estramustine
1
17beta-hydroxy steroid;
carbamate ester;
organochlorine compound		alkylating agent;
antineoplastic agent;
radiation protective agent		2010201014.0low000100
lupeol
1
pentacyclic triterpenoid;
secondary alcohol		anti-inflammatory drug;
plant metabolite		2010201014.0low000100
neocryptolepine
1
2010201014.0low000100
1-hydroxypentane-1,1-bisphosphonate
1
2010201014.0medium000100
cimadronate
1
2010201014.0low000100
1,1-hydroxyoctanodiphosphonate
1
2010201014.0medium000100
oxytocin
1
heterodetic cyclic peptide;
peptide hormone		oxytocic;
vasodilator agent		2010201014.0low000100
quinidine
1
cinchona alkaloidalpha-adrenergic antagonist;
anti-arrhythmia drug;
antimalarial;
drug allergen;
EC 1.14.13.181 (13-deoxydaunorubicin hydroxylase) inhibitor;
EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor;
muscarinic antagonist;
P450 inhibitor;
potassium channel blocker;
sodium channel blocker		2010201014.0low000100
digitoxin
1
cardenolide glycosideEC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor2010201014.0low000100
canaline
1
amino acid zwitterion;
non-proteinogenic L-alpha-amino acid		antimetabolite;
antineoplastic agent;
phytogenic insecticide;
plant metabolite		2010201014.0low000100
purvalanol a
1
purvalanol2010201014.0low000100
melphalan
1
L-phenylalanine derivative;
nitrogen mustard;
non-proteinogenic L-alpha-amino acid;
organochlorine compound		alkylating agent;
antineoplastic agent;
carcinogenic agent;
drug allergen;
immunosuppressive agent		2010201014.0low000100
Tetrahydropiperine
1
benzodioxoles2010201014.0medium000100
carbenoxolone
1
2010201014.0low000100
piperine
1
benzodioxoles;
N-acylpiperidine;
piperidine alkaloid;
tertiary carboxamide		food component;
human blood serum metabolite;
NF-kappaB inhibitor;
plant metabolite		2010201014.0low000100
ilepcimide
1
benzodioxoles2010201014.0low000100
leuprolide
1
oligopeptideanti-estrogen;
antineoplastic agent;
gonadotropin releasing hormone agonist		2010201014.0low000100
octotropine methylbromide
1
2010201014.0low000100
ipratropium bromide anhydrous
1
2010201014.0low000100
flunarizine
1
diarylmethane2010201014.0low000100
sulindac
1
monocarboxylic acid;
organofluorine compound;
sulfoxide		analgesic;
antineoplastic agent;
antipyretic;
apoptosis inducer;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
prodrug;
tocolytic agent		2010201014.0low000100
digoxin
1
cardenolide glycoside;
steroid saponin		anti-arrhythmia drug;
cardiotonic drug;
EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor;
epitope		2010201014.0low000100
ethionamide
1
pyridines;
thiocarboxamide		antilipemic drug;
antitubercular agent;
fatty acid synthesis inhibitor;
leprostatic drug;
prodrug		2010201014.0low000100
artemotil
1
artemisinin derivative2010201014.0low000100
gestodene
1
steroidestrogen2010201014.0low000100
glucametacin
1
2010201014.0low000100
quinine
3
cinchona alkaloidantimalarial;
muscle relaxant;
non-narcotic analgesic		2001201019.7low000300
alsterpaullone
1
C-nitro compound;
caprolactams;
organic heterotetracyclic compound		anti-HIV-1 agent;
antineoplastic agent;
apoptosis inducer;
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor;
EC 2.7.11.22 (cyclin-dependent kinase) inhibitor;
EC 2.7.11.26 (tau-protein kinase) inhibitor		2010201014.0low000100
alprostadil
1
prostaglandins Eanticoagulant;
human metabolite;
platelet aggregation inhibitor;
vasodilator agent		2010201014.0low000100
amphotericin b
1
antibiotic antifungal drug;
macrolide antibiotic;
polyene antibiotic		antiamoebic agent;
antiprotozoal drug;
bacterial metabolite		2010201014.0low000100
cynarine
1
alkyl caffeate ester;
quinic acid		plant metabolite2010201014.0low000100
triprolidine
1
N-alkylpyrrolidine;
olefinic compound;
pyridines		H1-receptor antagonist2010201014.0low000100
codeine
1
morphinane alkaloid;
organic heteropentacyclic compound		antitussive;
drug allergen;
environmental contaminant;
opioid analgesic;
opioid receptor agonist;
prodrug;
xenobiotic		2010201014.0low000100
dihydrocodeine
1
morphinane alkaloid2010201014.0low000100
ly 163892
1
carbacephem;
zwitterion		antibacterial drug;
antimicrobial agent		2010201014.0low000100
naloxone
1
morphinane alkaloid;
organic heteropentacyclic compound;
tertiary alcohol		antidote to opioid poisoning;
central nervous system depressant;
mu-opioid receptor antagonist		2010201014.0low000100
morphine
1
morphinane alkaloid;
organic heteropentacyclic compound;
tertiary amino compound		anaesthetic;
drug allergen;
environmental contaminant;
geroprotector;
mu-opioid receptor agonist;
opioid analgesic;
plant metabolite;
vasodilator agent;
xenobiotic		2010201014.0low000100
lacidipine
1
cinnamate ester;
tert-butyl ester		2010201014.0low000100
vinorelbine
1
acetate ester;
methyl ester;
organic heteropentacyclic compound;
organic heterotetracyclic compound;
ring assembly;
vinca alkaloid		antineoplastic agent;
photosensitizing agent		2010201014.0low000100
licochalcone a
1
chalcones2010201014.0low000100
stilbamidine
1
2010201014.0low000100
piperic acid
1
alpha,beta-unsaturated monocarboxylic acid;
benzodioxoles		plant metabolite2010201014.0low000100
isosungucine
2
2001200222.5high000200
proguanil
1
biguanides;
monochlorobenzenes		antimalarial;
antiprotozoal drug;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor		2010201014.0low000100
nifuroxime
1
2010201014.0medium000100
1-methyl-d-lysergic acid butanolamide
1
ergot alkaloid;
monocarboxylic acid amide		serotonergic antagonist;
sympatholytic agent;
vasoconstrictor agent		2010201014.0low000100
nifurtimox
1
nitrofuran antibiotic2010201014.0low000100
butylscopolammonium bromide
1
2010201014.0low000100
roxithromycin
1
roxithromycinenvironmental contaminant;
xenobiotic		2010201014.0low000100
artesunate
1
artemisinin derivative;
cyclic acetal;
dicarboxylic acid monoester;
hemisuccinate;
semisynthetic derivative;
sesquiterpenoid		antimalarial;
antineoplastic agent;
ferroptosis inducer		2010201014.0low000100
chlorproguanil
1
dichlorobenzene2010201014.0low000100
n1-phenyl-3,5-dinitro-n4,n4-di-n-propylsulfanilamide
1
2010201014.0medium000100
artenimol
1
2010201014.0low000100
4-phenoxyphenoxyethyl thiocyanate
1
2010201014.0low000100
diflucortolone
1
21-hydroxy steroid2010201014.0low000100
deoxoartemisinin
1
2010201014.0low000100
amodiaquine hydrochloride
1
2010201014.0low000100
valproate sodium
1
organic sodium saltgeroprotector2010201014.0low000100
butyrolactone i
1
butenolide2010201014.0low000100
ascorbic acid
1
ascorbic acid;
vitamin C		coenzyme;
cofactor;
flour treatment agent;
food antioxidant;
food colour retention agent;
geroprotector;
plant metabolite;
skin lightening agent		2010201014.0low000100
tetracycline
1
2010201014.0low000100
oxytetracycline, anhydrous
1
2010201014.0low000100
minocycline
1
2010201014.0low000100
piroxicam
1
benzothiazine;
monocarboxylic acid amide;
pyridines		analgesic;
antirheumatic drug;
cyclooxygenase 1 inhibitor;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
non-steroidal anti-inflammatory drug		2010201014.0low000100
mobiflex
1
heteroaryl hydroxy compound;
monocarboxylic acid amide;
pyridines;
thienothiazine		antipyretic;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug		2010201014.0low000100
rolitetracycline
1
2010201014.0low000100
rifampin
1
cyclic ketal;
hydrazone;
N-iminopiperazine;
N-methylpiperazine;
rifamycins;
semisynthetic derivative;
zwitterion		angiogenesis inhibitor;
antiamoebic agent;
antineoplastic agent;
antitubercular agent;
DNA synthesis inhibitor;
EC 2.7.7.6 (RNA polymerase) inhibitor;
Escherichia coli metabolite;
geroprotector;
leprostatic drug;
neuroprotective agent;
pregnane X receptor agonist;
protein synthesis inhibitor		2010201014.0low000100
clozapine
1
benzodiazepine;
N-arylpiperazine;
N-methylpiperazine;
organochlorine compound		adrenergic antagonist;
dopaminergic antagonist;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
environmental contaminant;
GABA antagonist;
histamine antagonist;
muscarinic antagonist;
second generation antipsychotic;
serotonergic antagonist;
xenobiotic		2010201014.0low000100
allopurinol
1
nucleobase analogue;
organic heterobicyclic compound		antimetabolite;
EC 1.17.3.2 (xanthine oxidase) inhibitor;
gout suppressant;
radical scavenger		2010201014.0low000100
thiolactomycin
1
2010201014.0low000100
3,4,5-trihydroxybenzamidoxime
1
benzenetriol2010201014.0low000100
ConditionIndicatedStudiesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
Parasite Infections0
1
2010201014.0high000100