Any drug used for its actions on cholinergic systems. Included here are agonists and antagonists, drugs that affect the life cycle of acetylcholine, and drugs that affect the survival of cholinergic neurons.
ChEBI ID: 38323
| Member | Definition | Class |
|---|---|---|
| dexpanthenol | A monocarboxylic acid amide that is 3,3-dimethylbutanamide substituted by hydroxy groups at positions 2 and 4 and a 3-hydroxypropyl group at the carbomyl nitrogen. | pantothenol |
| duodote | A pyridinium ion that is 1-methylpyridinium substituted by a (hydroxyimino)methyl group at position 2. | pralidoxime |
| galantamine | A benzazepine alkaloid isolated from certain species of daffodils. | galanthamine |
| minaprine | minaprine | |
| nizatidine | A member of the class of 1,3-thiazoles having a dimethylaminomethyl substituent at position 2 and an alkylthiomethyl moiety at position 4. | nizatidine |
| pralidoxime | A pyridinium ion that is 1-methylpyridinium substituted by a (hydroxyimino)methyl group at position 2. | pralidoxime |
| pralidoxime chloride | pralidoxime chloride | |
| pralidoxime iodide | An organic iodide salt that has pralidoxime as the cation. | pralidoxime iodide |
| pralidoxime iodide | An organic iodide salt that has pralidoxime as the cation. | pralidoxime iodide |
| rivastigmine | A carbamate ester obtained by formal condensation of the carboxy group of ethyl(methyl)carbamic acid with the phenolic OH group of 3-[(1S)-1-(dimethylamino)ethyl]phenol. A reversible cholinesterase inhibitor. | rivastigmine |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 519 (13.89) | 18.7374 |
| 1990's | 261 (6.99) | 18.2507 |
| 2000's | 1,275 (34.13) | 29.6817 |
| 2010's | 1,292 (34.58) | 24.3611 |
| 2020's | 389 (10.41) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 573 (12.89%) | 5.53% |
| Reviews | 595 (13.39%) | 6.00% |
| Case Studies | 255 (5.74%) | 4.05% |
| Observational | 34 (0.76%) | 0.25% |
| Other | 2,988 (67.22%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 17.7828 | 1 | 1 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 0.0794 | 1 | 1 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 0.0112 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 100.0000 | 1 | 1 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 7.9433 | 1 | 1 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 10.0000 | 2 | 2 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 10.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 10.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 10.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 10.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 10.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 10.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 10.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 10.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 10.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 10.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 10.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 10.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 10.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 10.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 10.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 10.0000 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 0.7079 | 1 | 1 |
| GLS protein | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| GTP-binding nuclear protein Ran isoform 1 | Homo sapiens (human) | Potency | 0.1158 | 1 | 1 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 0.1158 | 1 | 1 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 0.0025 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 2.6603 | 1 | 1 |
| snurportin-1 | Homo sapiens (human) | Potency | 0.1158 | 1 | 1 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 1.4125 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 59.6218 | 2 | 2 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Acetylcholine receptor subunit epsilon | Rattus norvegicus (Norway rat) | IC50 | 9.0000 | 1 | 1 |
| Acetylcholinesterase | Electrophorus electricus (electric eel) | IC50 | 24.4129 | 114 | 140 |
| Acetylcholinesterase | Homo sapiens (human) | IC50 | 86.0925 | 118 | 145 |
| Acetylcholinesterase | Mus musculus (house mouse) | IC50 | 4.5883 | 6 | 6 |
| Acetylcholinesterase | Rattus norvegicus (Norway rat) | IC50 | 7.1561 | 16 | 17 |
| Acetylcholinesterase | Tetronarce californica (Pacific electric ray) | IC50 | 21.2338 | 8 | 9 |
| Acetylcholinesterase | Electrophorus electricus (electric eel) | Ki | 22.1647 | 6 | 6 |
| Acetylcholinesterase | Homo sapiens (human) | Ki | 36.1348 | 5 | 5 |
| Acetylcholinesterase | Mus musculus (house mouse) | Ki | 5.6800 | 1 | 1 |
| Acetylcholinesterase | Tetronarce californica (Pacific electric ray) | Ki | 16.0950 | 1 | 2 |
| Acetylcholinesterase | Bos taurus (cattle) | IC50 | 88.9200 | 4 | 4 |
| Acyl-CoA desaturase 1 | Rattus norvegicus (Norway rat) | IC50 | 1.7100 | 1 | 1 |
| Amine oxidase [flavin-containing] A | Rattus norvegicus (Norway rat) | IC50 | 0.8750 | 1 | 2 |
| Amine oxidase [flavin-containing] B | Rattus norvegicus (Norway rat) | IC50 | 0.8750 | 1 | 2 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Beta-secretase 1 | Homo sapiens (human) | IC50 | 9.3950 | 1 | 2 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 567.0000 | 3 | 4 |
| Calcium/calmodulin-dependent protein kinase type II subunit alpha | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Calcium/calmodulin-dependent protein kinase type II subunit beta | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Calcium/calmodulin-dependent protein kinase type II subunit delta | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Calcium/calmodulin-dependent protein kinase type II subunit gamma | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| cAMP-dependent protein kinase catalytic subunit alpha | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| cAMP-dependent protein kinase catalytic subunit beta | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| cAMP-dependent protein kinase catalytic subunit gamma | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Carboxylic ester hydrolase | Equus caballus (horse) | IC50 | 9.4654 | 9 | 11 |
| Carboxylic ester hydrolase | Rattus norvegicus (Norway rat) | IC50 | 7.3825 | 4 | 4 |
| Carboxylic ester hydrolase | Equus caballus (horse) | Ki | 8.0000 | 1 | 1 |
| Chain A, Acetylcholinesterase | Tetronarce californica (Pacific electric ray) | IC50 | 0.5060 | 1 | 2 |
| Choline O-acetyltransferase | Rattus norvegicus (Norway rat) | IC50 | 184.7000 | 1 | 1 |
| Cholinesterase | Canis lupus familiaris (dog) | IC50 | 6.2700 | 1 | 1 |
| Cholinesterase | Equus caballus (horse) | IC50 | 12.4554 | 68 | 77 |
| Cholinesterase | Homo sapiens (human) | IC50 | 348.2829 | 68 | 85 |
| Cholinesterase | Mus musculus (house mouse) | IC50 | 0.8290 | 2 | 2 |
| Cholinesterase | Equus caballus (horse) | Ki | 7.7000 | 1 | 1 |
| Cholinesterase | Homo sapiens (human) | Ki | 104.6687 | 4 | 4 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 12.7300 | 1 | 1 |
| Delta-type opioid receptor | Mus musculus (house mouse) | IC50 | 23.5982 | 1 | 3 |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | IC50 | 3.2000 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | Ki | 17.0000 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-2 | Mus musculus (house mouse) | IC50 | 1,200.0000 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-3 | Mus musculus (house mouse) | IC50 | 1,200.0000 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-4 | Mus musculus (house mouse) | IC50 | 1,200.0000 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-5 | Mus musculus (house mouse) | IC50 | 1,200.0000 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-6 | Mus musculus (house mouse) | IC50 | 1,200.0000 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-7 | Mus musculus (house mouse) | IC50 | 1,200.0000 | 1 | 1 |
| Neuronal acetylcholine receptor subunit beta-2 | Mus musculus (house mouse) | IC50 | 1,200.0000 | 1 | 1 |
| Neuronal acetylcholine receptor subunit beta-3 | Mus musculus (house mouse) | IC50 | 1,200.0000 | 1 | 1 |
| Neuronal acetylcholine receptor subunit beta-4 | Mus musculus (house mouse) | IC50 | 1,200.0000 | 1 | 1 |
| Prolyl endopeptidase | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| Protein kinase C alpha type | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Protein kinase C beta type | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Protein kinase C delta type | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Protein kinase C epsilon type | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Protein kinase C eta type | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Protein kinase C gamma type | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Protein kinase C iota type | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Protein kinase C theta type | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Protein kinase C zeta type | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Serine/threonine-protein kinase D1 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Serine/threonine-protein kinase D3 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Small conductance calcium-activated potassium channel protein 3 | Rattus norvegicus (Norway rat) | IC50 | 12.7000 | 1 | 1 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | IC50 | 1.0000 | 1 | 1 |
| Sodium-dependent serotonin transporter | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 1 |
| Transporter | Rattus norvegicus (Norway rat) | IC50 | 1,200.0000 | 1 | 1 |
| Tyrosine-protein kinase SYK | Homo sapiens (human) | IC50 | 0.1600 | 1 | 1 |
| Vascular endothelial growth factor receptor 1 | Homo sapiens (human) | IC50 | 0.5900 | 1 | 1 |
| Vascular endothelial growth factor receptor 2 | Homo sapiens (human) | IC50 | 0.5900 | 1 | 1 |
| Vascular endothelial growth factor receptor 3 | Homo sapiens (human) | IC50 | 0.5900 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Acetylcholinesterase | Homo sapiens (human) | EC50 | 1.1000 | 1 | 1 |
| Acetylcholinesterase | Homo sapiens (human) | Kd | 348.7181 | 16 | 16 |
| Cholinesterase | Equus caballus (horse) | Kd | 1.1500 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Acetylcholinesterase | Homo sapiens (human) | K | 449.5000 | 8 | 8 |
| Acetylcholinesterase | Rattus norvegicus (Norway rat) | K diss | 210.0000 | 1 | 2 |
| Acetylcholinesterase | Homo sapiens (human) | kaKr/kr | 75,000,000.0000 | 1 | 1 |
| Acetylcholinesterase | Homo sapiens (human) | Kdiss | 5.0000 | 1 | 1 |
| Acetylcholinesterase | Homo sapiens (human) | Kr | 1,100,000,000.0000 | 1 | 1 |
| Acetylcholinesterase | Rattus norvegicus (Norway rat) | KR | 575.0000 | 1 | 1 |
| Acetylcholinesterase | Homo sapiens (human) | MIC | 0.0000 | 1 | 1 |
| Cholinesterase | Homo sapiens (human) | K | 58.3333 | 3 | 3 |
| Cholinesterase | Homo sapiens (human) | Kdiss | 1,887.5000 | 4 | 4 |
| Thyroid hormone receptor beta | Rattus norvegicus (Norway rat) | Kr | 1,100,000,000.0000 | 1 | 1 |