Page last updated: 2024-08-05 15:16:19
antiprotozoal drug
Any antimicrobial drug which is used to treat or prevent protozoal infections.
ChEBI ID: 35820
Members (26)
| Member | Definition | Class |
|---|---|---|
| amphotericin b | A macrolide antibiotic used to treat potentially life-threatening fungal infections. | amphotericin B |
| ascochlorin | A dihydroxybenzaldehyde that is 2,4-dihydroxybenzaldehyde which is substituted by a (1E,3E)-3-methyl-1-[(1R,2R,6R)-1,2,6-trimethyl-3-oxocyclohexyl]penta-1,3-dien-5-yl group at position 3, chlorine at position 5, and a methyl group at position 6. A meroterpenoid produced by several fungi including Ascochyta viciae . It exhibits anticancer, antifungal and antiprotozoal activities. | ascochlorin |
| ascofuranone | A dihydroxybenzaldehyde that is 2,4-dihydroxybenzaldehyde which is substituted by a (2E,6E)-7-[(2S)-5,5-dimethyl-4-oxotetrahydrofuran-2-yl]-3-methylocta-2,6-dien-1-yl group at position 3, chlorine at position 5, and a methyl group at position 6. A meroterpenoid produced by the soil fungus, Acremonium sclerotigenum. It is a promising drug candidate against the tropical disease, African trypanosomiasis. | ascofuranone |
| benzonidazole | A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2-nitroimidazol-1-yl)acetic acid with the aromatic amino group of benzylamine. Used for treatment of Chagas disease. | benznidazole |
| bortezomib | L-Phenylalaninamide substituted at the amide nitrogen by a 1-(dihydroxyboranyl)-3-methylbutyl group and at N(alpha) by a pyrazin-2-ylcarbonyl group. It is a dipeptidyl boronic acid that reversibly inhibits the 26S proteasome. | bortezomib |
| chlorquinaldol | A monohydroxyquinoline that is quinolin-8-ol which is substituted by a methyl group at position 2 and by chlorine at positions 5 and 7. An antifungal and antibacterial, it was formerly used for topical treatment of skin conditions and vaginal infections. | chlorquinaldol |
| clioquinol | A monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 are replaced by chlorine and iodine, respectively. It has antibacterial and atifungal properties, and is used in creams for the treatment of skin infections. It has also been investigated as a chelator of copper and zinc ions for the possible treatment of Alzheimer's disease. | 5-chloro-7-iodoquinolin-8-ol |
| cycloguanil | A triazine in which a 1,6-dihydro-1,3,5-triazine ring is substituted at N-1 by a 4-chlorophenyl group, at C-2 and -4 by amino groups and at C-6 by gem-dimethyl groups. A dihydrofolate reductase inhibitor, it is a metabolite of the antimalarial drug proguanil. | cycloguanil |
| dehydroemetine | A pyridoisoquinoline which was developed in response to the cardiovascular toxicity associated with emetine and results from the dehydrogenation of the heterotricylic ring of emetine. It is an antiprotozoal agent and displays antimalarial, antiamoebic, and antileishmanial properties. | dehydroemetine |
| diallyl trisulfide | An organic trisulfide that is trisulfane in which both of the hydrogens are replaced by allyl groups. A component of the essential oil of garlic and a major component of the traditional Chinese medicine allitridium, it exhibits antifungal, antitumour and antioxidant activity | diallyl trisulfide |
| dimetridazole | A C-nitro compound that is 5-nitroimidazole in which the hydrogens at positions 1 and 2 are replaced by methyl groups. An antiprotozoal drug, it has been banned by both the Government of Canada and the European Union as a livestock feed additive owing to suspicions of it being carcinogenic. | dimetridazole |
| emetine | A pyridoisoquinoline comprising emetam having methoxy substituents at the 6'-, 7'-, 10- and 11-positions. It is an antiprotozoal agent and emetic. It inhibits SARS-CoV2, Zika and Ebola virus replication and displays antimalarial, antineoplastic and antiamoebic properties. | emetine |
| emetine dihydrochloride | The dihydrochloride salt of emetine. | emetine dihydrochloride |
| fumagillin | A meroterpenoid resulting from the formal condensation of the hydroxy group of fumagillol with the carboxylic acid group of (all-E)-deca-2,4,6,8-tetraenedioic acid. Originally isolated from the fungus Aspergillus fumigatus, it is used for the control of Nosema infection in honey bees. | fumagillin |
| imidocarb | imidocarb | |
| iodoquinol | A monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 are replaced by iodine. It is considered the drug of choice for treating asymptomatic or moderate forms of amoebiasis. | iodoquinol |
| miltefosine | A phospholipid that is the hexadecyl monoester of phosphocholine. | miltefosine |
| nitarsone | An organoarsonic acid where the organyl group is 4-nitrophenyl. | nitarsone |
| ornidazole | A C-nitro compound that is 5-nitroimidazole in which the hydrogens at positions 1 and 2 are replaced by 3-chloro-2-hydroxypropyl and methyl groups, respectively. It is used in the treatment of susceptible protozoal infections and for the treatment of anaerobic bacterial infections. | ornidazole |
| paromomycin | An amino cyclitol glycoside that is the 1-O-(2-amino-2-deoxy-alpha-D-glucopyranoside) and the 3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranoside of 4,6-diamino-2,3-dihydroxycyclohexane (the 1R,2R,3S,4R,6S diastereoisomer). It is obtained from various Streptomyces species. A broad-spectrum antibiotic, it is used (generally as the sulfate salt) for the treatment of acute and chronic intestinal protozoal infections, but is not effective for extraintestinal protozoal infections. It is also used as a therapeutic against visceral leishmaniasis. | paromomycin |
| proguanil | A biguanide compound which has isopropyl and p-chlorophenyl substituents on the terminal N atoms. A prophylactic antimalarial drug, it works by inhibiting the enzyme dihydrofolate reductase, which is involved in the reproduction of the malaria parasites Plasmodium falciparum and P. vivax within the red blood cells. | proguanil |
| psi-baptigenin | A member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone and in which the phenyl group at position 3 is replaced by a 1,3-benzodioxol-5-yl group. | pseudobaptigenin |
| pyrimethamine | An aminopyrimidine that is pyrimidine-2,4-diamine which is substituted at position 5 by a p-chlorophenyl group and at position 6 by an ethyl group. It is a folic acid antagonist used as an antimalarial or with a sulfonamide to treat toxoplasmosis. | pyrimethamine |
| ronidazole | A carbamate ester that is 5-nitroimidazole in which the hydrogens at positions 1 and 2 are replaced by methyl and (carbamoyloxy)methyl groups, respectively. An antiprotozoal agent, it is used in veterinary medicine for the treatment of histomoniasis and swine dysentery. | ronidazole |
| sulfadiazine | A sulfonamide consisting of pyrimidine with a 4-aminobenzenesulfonamido group at the 2-position. | sulfadiazine |
| tinidazole | 1H-imidazole substituted at C-1 by a (2-ethylsulfonyl)ethyl group, at C-2 by a methyl group and at C-5 by a nitro group. It is used as an antiprotozoal, antibacterial agent. | tinidazole |
Research
Studies (39,331)
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 11,701 (29.75) | 18.7374 |
| 1990's | 4,999 (12.71) | 18.2507 |
| 2000's | 8,244 (20.96) | 29.6817 |
| 2010's | 11,112 (28.25) | 24.3611 |
| 2020's | 3,275 (8.33) | 2.80 |
Study Types
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 3,380 (7.67%) | 5.53% |
| Reviews | 3,926 (8.90%) | 6.00% |
| Case Studies | 7,344 (16.65%) | 4.05% |
| Observational | 131 (0.30%) | 0.25% |
| Other | 29,315 (66.48%) | 84.16% |
Protein Targets (414)
Potency Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 31.7626 | 1 | 3 |
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 24.2308 | 1 | 3 |
| 67.9K protein | Vaccinia virus | Potency | 21.6862 | 2 | 12 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 0.7762 | 1 | 1 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 12.3195 | 2 | 4 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 26.5904 | 1 | 5 |
| Alpha-synuclein | Homo sapiens (human) | Potency | 4.0075 | 1 | 2 |
| apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 1.7783 | 1 | 2 |
| AR protein | Homo sapiens (human) | Potency | 17.9917 | 11 | 64 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 24.4671 | 3 | 7 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 11.4003 | 3 | 3 |
| Ataxin-2 | Homo sapiens (human) | Potency | 11.5588 | 2 | 10 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 8.6678 | 2 | 14 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 17.7828 | 2 | 2 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 34.5051 | 1 | 2 |
| caspase-3 | Cricetulus griseus (Chinese hamster) | Potency | 15.3690 | 1 | 2 |
| caspase-3 | Homo sapiens (human) | Potency | 34.5051 | 1 | 2 |
| Caspase-7 | Cricetulus griseus (Chinese hamster) | Potency | 15.3690 | 1 | 2 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 14.8284 | 3 | 25 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 14.0247 | 2 | 7 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 27.2112 | 1 | 5 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 8.4845 | 1 | 3 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 21.9908 | 1 | 7 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 25.1189 | 1 | 1 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 32.1841 | 2 | 3 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 67.8334 | 1 | 2 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 32.9459 | 2 | 5 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 19.6780 | 1 | 5 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 32.1841 | 2 | 3 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 86.3398 | 1 | 4 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 25.6018 | 1 | 2 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 8.9716 | 1 | 2 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 22.7237 | 2 | 9 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 15.6020 | 2 | 10 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 13.7626 | 1 | 8 |
| Disintegrin and metalloproteinase domain-containing protein 17 | Homo sapiens (human) | Potency | 1.2988 | 1 | 3 |
| DNA dC->dU-editing enzyme APOBEC-3F isoform a | Homo sapiens (human) | Potency | 14.3484 | 1 | 2 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 85.8943 | 1 | 3 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 18.2136 | 11 | 89 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 21.6727 | 2 | 11 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 14.4991 | 9 | 65 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 25.2496 | 1 | 6 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 2.6922 | 4 | 8 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 28.6621 | 4 | 12 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 30.8212 | 1 | 4 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 20.0863 | 1 | 4 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 23.6136 | 1 | 5 |
| GALC protein | Homo sapiens (human) | Potency | 0.7079 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 23.6136 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 23.6136 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 23.6136 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 23.6136 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 23.6136 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 23.6136 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 23.6136 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 23.6136 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 23.6136 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 23.6136 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 23.6136 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 23.6136 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 23.6136 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 23.6136 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 23.6136 | 1 | 5 |
| geminin | Homo sapiens (human) | Potency | 12.9259 | 4 | 20 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 16.2225 | 3 | 23 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 13.1911 | 1 | 4 |
| GLS protein | Homo sapiens (human) | Potency | 26.6320 | 1 | 2 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 12.0218 | 4 | 17 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 25.0543 | 1 | 11 |
| Glycoprotein hormones alpha chain | Homo sapiens (human) | Potency | 3.1623 | 1 | 1 |
| heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | Homo sapiens (human) | Potency | 40.9903 | 1 | 3 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 7.4495 | 2 | 7 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 31.0990 | 1 | 2 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 37.7730 | 2 | 14 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 17.7067 | 1 | 4 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 19.3518 | 1 | 6 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 3.2988 | 3 | 7 |
| IDH1 | Homo sapiens (human) | Potency | 3.3624 | 1 | 4 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 23.1103 | 1 | 3 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 23.1103 | 1 | 3 |
| Interferon beta | Homo sapiens (human) | Potency | 3.9703 | 2 | 9 |
| interleukin 8 | Homo sapiens (human) | Potency | 47.3079 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 5.7879 | 2 | 13 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 40.5334 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 23.8195 | 2 | 3 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 22.7496 | 2 | 3 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 21.4509 | 1 | 2 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 2.5119 | 1 | 1 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 4.2278 | 1 | 3 |
| NPC intracellular cholesterol transporter 1 precursor | Homo sapiens (human) | Potency | 58.0479 | 1 | 1 |
| Nrf2 | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 22.2373 | 4 | 28 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 12.0472 | 1 | 3 |
| nuclear factor NF-kappa-B p105 subunit isoform 1 | Homo sapiens (human) | Potency | 17.7828 | 1 | 1 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 33.6204 | 1 | 2 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 42.8458 | 1 | 3 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 1.1060 | 2 | 12 |
| nuclear receptor subfamily 1, group I, member 2 | Rattus norvegicus (Norway rat) | Potency | 2.8354 | 1 | 4 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 16.9965 | 3 | 28 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| Parkin | Homo sapiens (human) | Potency | 9.2000 | 1 | 1 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 84.9214 | 1 | 1 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 11.0878 | 2 | 9 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 0.0757 | 1 | 1 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 22.2804 | 5 | 22 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 29.4716 | 5 | 14 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 50.2462 | 1 | 4 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 0.7079 | 1 | 1 |
| polyprotein | Zika virus | Potency | 20.0863 | 1 | 4 |
| polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | Potency | 0.7079 | 1 | 1 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 16.4324 | 1 | 6 |
| PPM1D protein | Homo sapiens (human) | Potency | 0.3500 | 1 | 4 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 28.3045 | 2 | 12 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 50.1187 | 1 | 1 |
| progesterone receptor | Homo sapiens (human) | Potency | 9.1579 | 2 | 9 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 20.8349 | 2 | 22 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 18.3564 | 1 | 1 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 70.7946 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 26.6321 | 3 | 21 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 8.7140 | 3 | 11 |
| serine/threonine-protein kinase mTOR isoform 1 | Homo sapiens (human) | Potency | 3.5306 | 2 | 2 |
| serine/threonine-protein kinase PLK1 | Homo sapiens (human) | Potency | 23.7781 | 1 | 1 |
| signal transducer and activator of transcription 6, interleukin-4 induced | Homo sapiens (human) | Potency | 25.2783 | 3 | 3 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 30.5214 | 2 | 2 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 30.5214 | 2 | 2 |
| Smad3 | Homo sapiens (human) | Potency | 24.8502 | 1 | 4 |
| snurportin-1 | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 24.5694 | 1 | 5 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 17.0990 | 1 | 8 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 23.7805 | 1 | 4 |
| TDP1 protein | Homo sapiens (human) | Potency | 7.9578 | 2 | 32 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 56.6072 | 1 | 2 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 34.3097 | 1 | 5 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 11.4308 | 3 | 27 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 26.7142 | 4 | 5 |
| thyrotropin-releasing hormone receptor | Homo sapiens (human) | Potency | 26.9724 | 1 | 1 |
| transcriptional regulator ERG isoform 3 | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| tumor necrosis factor | Homo sapiens (human) | Potency | 42.1632 | 1 | 1 |
| ubiquitin carboxyl-terminal hydrolase 2 isoform a | Homo sapiens (human) | Potency | 1.2988 | 1 | 3 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 0.7079 | 1 | 1 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 0.7079 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 59.6218 | 1 | 2 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 20.2120 | 2 | 13 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 12.8655 | 4 | 9 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 38.8468 | 1 | 4 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 25.0543 | 1 | 11 |
| Vpr | Human immunodeficiency virus 1 | Potency | 10.0000 | 1 | 1 |
Inhibition Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 26S proteasome complex subunit SEM1 | Homo sapiens (human) | IC50 | 0.5335 | 4 | 4 |
| 26S proteasome non-ATPase regulatory subunit 1 | Homo sapiens (human) | IC50 | 0.5335 | 4 | 4 |
| 26S proteasome non-ATPase regulatory subunit 11 | Homo sapiens (human) | IC50 | 0.5335 | 4 | 4 |
| 26S proteasome non-ATPase regulatory subunit 12 | Homo sapiens (human) | IC50 | 0.5335 | 4 | 4 |
| 26S proteasome non-ATPase regulatory subunit 13 | Homo sapiens (human) | IC50 | 0.5335 | 4 | 4 |
| 26S proteasome non-ATPase regulatory subunit 14 | Homo sapiens (human) | IC50 | 0.5335 | 4 | 4 |
| 26S proteasome non-ATPase regulatory subunit 2 | Homo sapiens (human) | IC50 | 0.5335 | 4 | 4 |
| 26S proteasome non-ATPase regulatory subunit 3 | Homo sapiens (human) | IC50 | 0.5335 | 4 | 4 |
| 26S proteasome non-ATPase regulatory subunit 4 | Homo sapiens (human) | IC50 | 0.5335 | 4 | 4 |
| 26S proteasome non-ATPase regulatory subunit 6 | Homo sapiens (human) | IC50 | 0.5335 | 4 | 4 |
| 26S proteasome non-ATPase regulatory subunit 7 | Homo sapiens (human) | IC50 | 0.5335 | 4 | 4 |
| 26S proteasome non-ATPase regulatory subunit 8 | Homo sapiens (human) | IC50 | 0.5335 | 4 | 4 |
| 26S proteasome regulatory subunit 10B | Homo sapiens (human) | IC50 | 0.5335 | 4 | 4 |
| 26S proteasome regulatory subunit 4 | Homo sapiens (human) | IC50 | 0.5335 | 4 | 4 |
| 26S proteasome regulatory subunit 6A | Homo sapiens (human) | IC50 | 0.5335 | 4 | 4 |
| 26S proteasome regulatory subunit 6B | Homo sapiens (human) | IC50 | 0.5335 | 4 | 4 |
| 26S proteasome regulatory subunit 7 | Homo sapiens (human) | IC50 | 0.5335 | 4 | 4 |
| 26S proteasome regulatory subunit 8 | Homo sapiens (human) | IC50 | 0.5335 | 4 | 4 |
| 30S ribosomal protein S1 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 30S ribosomal protein S10 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 30S ribosomal protein S11 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 30S ribosomal protein S12 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 30S ribosomal protein S13 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 30S ribosomal protein S14 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 30S ribosomal protein S15 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 30S ribosomal protein S16 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 30S ribosomal protein S17 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 30S ribosomal protein S18 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 30S ribosomal protein S19 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 30S ribosomal protein S2 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 30S ribosomal protein S20 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 30S ribosomal protein S21 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 30S ribosomal protein S3 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 30S ribosomal protein S4 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 30S ribosomal protein S5 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 30S ribosomal protein S6 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 30S ribosomal protein S7 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 30S ribosomal protein S8 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 30S ribosomal protein S9 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L1 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L10 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L11 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L13 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L14 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L15 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L16 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L17 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L18 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L19 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L2 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L20 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L21 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L22 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L23 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L24 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L25 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L27 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L28 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L29 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L3 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L30 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L31 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L31 type B | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L32 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L33 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L34 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L35 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L36 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L36 2 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L4 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L5 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L6 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 50S ribosomal protein L7/L12 | Escherichia coli K-12 | IC50 | 0.0355 | 2 | 2 |
| 90-kda heat shock protein beta HSP90 beta, partial | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Acetylcholinesterase | Homo sapiens (human) | IC50 | 0.5900 | 1 | 1 |
| Adenosine receptor A3 | Homo sapiens (human) | IC50 | 0.9330 | 1 | 1 |
| Adenosine receptor A3 | Homo sapiens (human) | Ki | 0.5270 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.9330 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.5270 | 1 | 1 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.9330 | 1 | 1 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.5270 | 1 | 1 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | IC50 | 0.0380 | 1 | 1 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | Ki | 0.0140 | 1 | 1 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | IC50 | 0.1820 | 1 | 1 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | Ki | 0.0260 | 1 | 1 |
| Alternative oxidase, mitochondrial | Trypanosoma brucei brucei | IC50 | 0.0020 | 1 | 1 |
| Alternative oxidase, mitochondrial | Trypanosoma brucei brucei | Ki | 0.0001 | 1 | 1 |
| Amyloid-beta precursor protein | Homo sapiens (human) | IC50 | 39.8667 | 3 | 3 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 7 |
| ATP-dependent Clp protease proteolytic subunit | Staphylococcus aureus subsp. aureus NCTC 8325 | IC50 | 5.3000 | 1 | 1 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | IC50 | 72.7571 | 7 | 7 |
| Aurora kinase A | Homo sapiens (human) | IC50 | 21.0000 | 1 | 1 |
| Aurora kinase B | Homo sapiens (human) | IC50 | 100.0000 | 1 | 3 |
| Beta-carbonic anhydrase 1 | Mycobacterium tuberculosis H37Rv | Ki | 7.3000 | 1 | 1 |
| Beta-hexosaminidase subunit alpha | Homo sapiens (human) | IC50 | 11.0833 | 6 | 6 |
| Beta-hexosaminidase subunit beta | Homo sapiens (human) | IC50 | 10.2286 | 7 | 7 |
| Bifunctional dihydrofolate reductase-thymidylate synthase | Cryptosporidium parvum | IC50 | 1,000.0000 | 1 | 1 |
| Bifunctional dihydrofolate reductase-thymidylate synthase | Plasmodium falciparum 3D7 | IC50 | 2.4800 | 1 | 1 |
| Bifunctional dihydrofolate reductase-thymidylate synthase | Plasmodium falciparum K1 | IC50 | 28.2988 | 10 | 14 |
| Bifunctional dihydrofolate reductase-thymidylate synthase | Toxoplasma gondii | IC50 | 0.3217 | 11 | 11 |
| Bifunctional dihydrofolate reductase-thymidylate synthase | Plasmodium falciparum 3D7 | Ki | 0.0008 | 1 | 1 |
| Bifunctional dihydrofolate reductase-thymidylate synthase | Plasmodium falciparum K1 | Ki | 0.2639 | 23 | 40 |
| Bifunctional dihydrofolate reductase-thymidylate synthase | Plasmodium vivax (malaria parasite P. vivax) | Ki | 0.0016 | 1 | 2 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 338.5462 | 3 | 13 |
| Botulinum neurotoxin type A | Clostridium botulinum | IC50 | 15.2000 | 1 | 2 |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 | Homo sapiens (human) | IC50 | 122.5000 | 2 | 2 |
| Calcium-dependent protein kinase 1 | Plasmodium falciparum 3D7 | IC50 | 1.0000 | 1 | 1 |
| Calcium-dependent protein kinase 4 | Plasmodium falciparum 3D7 | IC50 | 1.0000 | 1 | 1 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4D | Homo sapiens (human) | IC50 | 10.0000 | 2 | 2 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 7 |
| Carbonic anhydrase 1 | Homo sapiens (human) | IC50 | 12.7203 | 1 | 3 |
| Carbonic anhydrase 1 | Homo sapiens (human) | Ki | 1.2900 | 2 | 2 |
| Carbonic anhydrase 12 | Homo sapiens (human) | Ki | 5.8700 | 1 | 1 |
| Carbonic anhydrase 13 | Homo sapiens (human) | Ki | 8.4500 | 1 | 1 |
| Carbonic anhydrase 14 | Homo sapiens (human) | Ki | 3.2800 | 1 | 1 |
| Carbonic anhydrase 15 | Mus musculus (house mouse) | Ki | 2.5050 | 2 | 2 |
| Carbonic anhydrase 2 | Homo sapiens (human) | IC50 | 12.7203 | 1 | 3 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 1.1600 | 2 | 2 |
| Carbonic anhydrase 3 | Homo sapiens (human) | Ki | 4.5700 | 1 | 1 |
| Carbonic anhydrase 4 | Homo sapiens (human) | Ki | 6.5100 | 1 | 1 |
| Carbonic anhydrase 5A, mitochondrial | Homo sapiens (human) | Ki | 6.9200 | 1 | 1 |
| Carbonic anhydrase 5B, mitochondrial | Homo sapiens (human) | Ki | 6.8300 | 1 | 1 |
| Carbonic anhydrase 6 | Homo sapiens (human) | IC50 | 12.7203 | 1 | 3 |
| Carbonic anhydrase 6 | Homo sapiens (human) | Ki | 4.3800 | 1 | 1 |
| Carbonic anhydrase 7 | Homo sapiens (human) | Ki | 6.9400 | 1 | 1 |
| Carbonic anhydrase 9 | Homo sapiens (human) | Ki | 3.3800 | 1 | 1 |
| Catechol O-methyltransferase | Rattus norvegicus (Norway rat) | IC50 | 5.2049 | 1 | 2 |
| Cathepsin B | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
| Cathepsin G | Homo sapiens (human) | IC50 | 1.8100 | 2 | 2 |
| Cathepsin G | Homo sapiens (human) | Ki | 0.6300 | 1 | 1 |
| Cdk-related protein kinase 6 | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 1.0000 | 1 | 1 |
| cGMP-dependent 3',5'-cyclic phosphodiesterase | Homo sapiens (human) | IC50 | 39.6500 | 1 | 2 |
| Chain H, Proteasome component PUP1 | Saccharomyces cerevisiae (brewer's yeast) | Ki | 0.0006 | 1 | 1 |
| Chain I, Proteasome component PUP3 | Saccharomyces cerevisiae (brewer's yeast) | Ki | 0.0006 | 1 | 1 |
| Chain K, Proteasome component PRE2 | Saccharomyces cerevisiae (brewer's yeast) | Ki | 0.0006 | 1 | 2 |
| Chain L, Proteasome component C5 | Saccharomyces cerevisiae (brewer's yeast) | Ki | 0.0006 | 1 | 2 |
| Chymase | Homo sapiens (human) | IC50 | 1.1900 | 1 | 1 |
| Chymotrypsinogen A | Bos taurus (cattle) | Ki | 2.4000 | 1 | 1 |
| Chymotrypsinogen B | Homo sapiens (human) | Ki | 0.3200 | 1 | 1 |
| Cyclin-dependent kinase 1 | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| Cytochrome P450 1A2 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 3 |
| Cytochrome P450 2C19 | Homo sapiens (human) | IC50 | 98.6667 | 1 | 3 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 3 |
| Cytochrome P450 2C9 | Homo sapiens (human) | Ki | 51.5000 | 1 | 1 |
| Cytochrome P450 2D6 | Homo sapiens (human) | IC50 | 92.6000 | 1 | 3 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 99.4000 | 1 | 3 |
| delta-type opioid receptor | Homo sapiens (human) | IC50 | 32.0000 | 1 | 1 |
| Dihydrofolate reductase | Candida albicans | IC50 | 5.0000 | 1 | 1 |
| Dihydrofolate reductase | Escherichia coli K-12 | IC50 | 9.8367 | 3 | 3 |
| Dihydrofolate reductase | Homo sapiens (human) | IC50 | 3.1057 | 7 | 7 |
| Dihydrofolate reductase | Pneumocystis carinii | IC50 | 2.9389 | 8 | 9 |
| Dihydrofolate reductase | Rattus norvegicus (Norway rat) | IC50 | 1.9092 | 11 | 12 |
| Dihydrofolate reductase | Escherichia coli K-12 | Ki | 0.2230 | 6 | 6 |
| Dihydrofolate reductase | Gallus gallus (chicken) | Ki | 0.1122 | 1 | 1 |
| Dihydrofolate reductase | Homo sapiens (human) | Ki | 3.7092 | 10 | 12 |
| Dihydrofolate reductase | Lacticaseibacillus casei | Ki | 17.3780 | 1 | 1 |
| Dihydrofolate reductase | Pneumocystis carinii | Ki | 27.2857 | 3 | 4 |
| Dihydrofolate reductase | Bos taurus (cattle) | IC50 | 0.1007 | 2 | 2 |
| Dihydroorotate dehydrogenase | Leishmania major | IC50 | 1,037.0000 | 1 | 2 |
| Dihydroorotate dehydrogenase (quinone), mitochondrial | Homo sapiens (human) | IC50 | 3.3500 | 1 | 2 |
| Dipeptidyl peptidase 4 | Homo sapiens (human) | IC50 | 0.3900 | 1 | 1 |
| dual specificity protein phosphatase 3 | Homo sapiens (human) | IC50 | 80.0000 | 2 | 2 |
| Endothelial PAS domain-containing protein 1 | Homo sapiens (human) | IC50 | 0.0965 | 2 | 2 |
| Epidermal growth factor receptor | Homo sapiens (human) | IC50 | 1.8890 | 1 | 1 |
| Fatty acid synthase | Gallus gallus (chicken) | IC50 | 8.3700 | 2 | 2 |
| Glucose transporter | Leishmania mexicana | IC50 | 6.0405 | 1 | 2 |
| Glyceraldehyde-3-phosphate dehydrogenase | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| heat shock protein HSP 90-alpha isoform 2 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Hexose transporter 1 | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 6.0450 | 1 | 2 |
| Histone deacetylase 1 | Homo sapiens (human) | IC50 | 66.3880 | 2 | 15 |
| Histone deacetylase 11 | Homo sapiens (human) | IC50 | 71.0857 | 1 | 14 |
| Histone deacetylase 2 | Homo sapiens (human) | IC50 | 66.4000 | 2 | 15 |
| Histone deacetylase 3 | Homo sapiens (human) | IC50 | 66.4253 | 2 | 15 |
| Histone deacetylase 4 | Homo sapiens (human) | IC50 | 71.0857 | 1 | 14 |
| Histone deacetylase 5 | Homo sapiens (human) | IC50 | 71.0857 | 1 | 14 |
| Histone deacetylase 6 | Homo sapiens (human) | IC50 | 70.9760 | 2 | 15 |
| Histone deacetylase 7 | Homo sapiens (human) | IC50 | 71.0857 | 1 | 14 |
| Histone deacetylase 8 | Homo sapiens (human) | IC50 | 66.3515 | 2 | 15 |
| Histone deacetylase 9 | Homo sapiens (human) | IC50 | 71.0857 | 1 | 14 |
| Hypoxia-inducible factor 1-alpha | Homo sapiens (human) | IC50 | 0.0965 | 2 | 2 |
| kappa-type opioid receptor isoform 1 | Homo sapiens (human) | IC50 | 18.8950 | 2 | 2 |
| Lon protease homolog, mitochondrial | Homo sapiens (human) | IC50 | 0.1830 | 1 | 1 |
| Low molecular weight phosphotyrosine protein phosphatase | Homo sapiens (human) | IC50 | 15.6150 | 2 | 2 |
| low molecular weight phosphotyrosine protein phosphatase isoform c | Homo sapiens (human) | IC50 | 28.2500 | 2 | 2 |
| Lysine--tRNA ligase | Plasmodium falciparum 3D7 | IC50 | 2.5000 | 1 | 1 |
| Lysosomal protective protein | Homo sapiens (human) | IC50 | 9.2000 | 1 | 1 |
| M-phase inducer phosphatase 1 | Homo sapiens (human) | IC50 | 25.0000 | 1 | 1 |
| Methionine aminopeptidase | Escherichia coli K-12 | IC50 | 100.0000 | 1 | 1 |
| Methionine aminopeptidase 1 | Saccharomyces cerevisiae S288C | IC50 | 100.0000 | 1 | 1 |
| Methionine aminopeptidase 2 | Homo sapiens (human) | IC50 | 0.0082 | 4 | 4 |
| Mitogen-activated protein kinase | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 1.0000 | 1 | 1 |
| Mitogen-activated protein kinase 1 | Homo sapiens (human) | IC50 | 0.2940 | 1 | 1 |
| Mitogen-activated protein kinase 14 | Homo sapiens (human) | IC50 | 0.3640 | 1 | 1 |
| Mitogen-activated protein kinase 3 | Homo sapiens (human) | IC50 | 5.2640 | 1 | 1 |
| Multidrug and toxin extrusion protein 1 | Mus musculus (house mouse) | Ki | 0.1450 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 7 |
| NACHT, LRR and PYD domains-containing protein 3 | Mus musculus (house mouse) | IC50 | 0.0407 | 1 | 1 |
| Neutrophil elastase | Homo sapiens (human) | Ki | 2.3000 | 1 | 1 |
| Nuclear factor NF-kappa-B p100 subunit | Homo sapiens (human) | IC50 | 0.0850 | 1 | 1 |
| Nuclear factor NF-kappa-B p105 subunit | Homo sapiens (human) | IC50 | 0.0850 | 1 | 1 |
| Platelet-activating factor receptor | Cavia porcellus (domestic guinea pig) | IC50 | 200.0000 | 1 | 1 |
| Polyamine deacetylase HDAC10 | Homo sapiens (human) | IC50 | 71.0857 | 1 | 14 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 3 |
| Proline--tRNA ligase | Plasmodium falciparum 3D7 | IC50 | 2.5000 | 1 | 1 |
| Proteasomal ubiquitin receptor ADRM1 | Homo sapiens (human) | IC50 | 0.5335 | 4 | 4 |
| Proteasome subunit alpha type-1 | Homo sapiens (human) | IC50 | 0.3213 | 7 | 7 |
| Proteasome subunit alpha type-2 | Homo sapiens (human) | IC50 | 0.3213 | 7 | 7 |
| Proteasome subunit alpha type-3 | Homo sapiens (human) | IC50 | 0.3213 | 7 | 7 |
| Proteasome subunit alpha type-4 | Homo sapiens (human) | IC50 | 0.3213 | 7 | 7 |
| Proteasome subunit alpha type-5 | Homo sapiens (human) | IC50 | 0.3213 | 7 | 7 |
| Proteasome subunit alpha type-6 | Homo sapiens (human) | IC50 | 0.3213 | 7 | 7 |
| Proteasome subunit alpha type-7 | Homo sapiens (human) | IC50 | 0.3213 | 7 | 7 |
| Proteasome subunit alpha-type 8 | Homo sapiens (human) | IC50 | 0.3213 | 7 | 7 |
| Proteasome subunit beta type-1 | Homo sapiens (human) | IC50 | 0.2149 | 18 | 18 |
| Proteasome subunit beta type-10 | Homo sapiens (human) | IC50 | 0.5359 | 10 | 10 |
| Proteasome subunit beta type-11 | Homo sapiens (human) | IC50 | 0.3213 | 7 | 7 |
| Proteasome subunit beta type-2 | Homo sapiens (human) | IC50 | 2.9860 | 19 | 19 |
| Proteasome subunit beta type-3 | Homo sapiens (human) | IC50 | 0.3213 | 7 | 7 |
| Proteasome subunit beta type-4 | Homo sapiens (human) | IC50 | 0.3213 | 7 | 7 |
| Proteasome subunit beta type-5 | Homo sapiens (human) | IC50 | 15,084.2836 | 32 | 34 |
| Proteasome subunit beta type-5 | Homo sapiens (human) | Ki | 0.0067 | 3 | 3 |
| Proteasome subunit beta type-6 | Homo sapiens (human) | IC50 | 0.2842 | 8 | 8 |
| Proteasome subunit beta type-7 | Homo sapiens (human) | IC50 | 1.8772 | 8 | 8 |
| Proteasome subunit beta type-8 | Homo sapiens (human) | IC50 | 0.1681 | 14 | 14 |
| Proteasome subunit beta type-8 | Mus musculus (house mouse) | IC50 | 0.0168 | 1 | 1 |
| Proteasome subunit beta type-9 | Homo sapiens (human) | IC50 | 0.2059 | 11 | 11 |
| Protein kinase domain-containing protein | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 1.0000 | 1 | 1 |
| Prothrombin | Homo sapiens (human) | Ki | 13.0000 | 1 | 1 |
| Pteridine reductase 1 | Leishmania major | IC50 | 13.6000 | 1 | 1 |
| RAC-alpha serine/threonine-protein kinase | Homo sapiens (human) | IC50 | 9.6000 | 1 | 1 |
| Receptor tyrosine-protein kinase erbB-2 | Homo sapiens (human) | IC50 | 8.5770 | 1 | 1 |
| Serine hydrolase RBBP9 | Homo sapiens (human) | IC50 | 7.8000 | 1 | 1 |
| Solute carrier family 2, facilitated glucose transporter member 1 | Homo sapiens (human) | IC50 | 6.0540 | 1 | 2 |
| Solute carrier family 22 member 1 | Mus musculus (house mouse) | Ki | 3.6000 | 1 | 1 |
| Solute carrier family 22 member 1 | Homo sapiens (human) | IC50 | 13.5700 | 1 | 1 |
| Spike glycoprotein | Severe acute respiratory syndrome coronavirus 2 | IC50 | 5.6000 | 1 | 1 |
| Substance-K receptor | Rattus norvegicus (Norway rat) | Ki | 0.0717 | 1 | 1 |
| Transcription factor p65 | Homo sapiens (human) | IC50 | 0.0850 | 1 | 1 |
| Tyrosine-protein kinase Fyn | Homo sapiens (human) | IC50 | 1.5710 | 1 | 1 |
| Tyrosine-protein kinase Lck | Homo sapiens (human) | IC50 | 2.4610 | 1 | 1 |
| tyrosine-protein phosphatase non-receptor type 22 isoform 1 | Homo sapiens (human) | IC50 | 80.0000 | 2 | 2 |
| Tyrosyl-DNA phosphodiesterase 1 | Homo sapiens (human) | IC50 | 21,000.0000 | 1 | 1 |
Activation Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | EC50 | 31.5000 | 1 | 1 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | EC50 | 31.5000 | 1 | 1 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | EC50 | 31.5000 | 1 | 1 |
| Angiotensin-converting enzyme 2 | Homo sapiens (human) | EC50 | 0.0325 | 1 | 2 |
| ATP-dependent Clp protease proteolytic subunit | Staphylococcus aureus subsp. aureus NCTC 8325 | EC50 | 23.5000 | 1 | 1 |
| Beta-galactosidase | Escherichia coli | EC50 | 31.5000 | 1 | 1 |
| citrate synthase 2, partial | Saccharomyces cerevisiae (brewer's yeast) | EC50 | 166.3000 | 1 | 1 |
| delta-type opioid receptor | Homo sapiens (human) | EC50 | 32.0000 | 1 | 1 |
| Dihydrofolate reductase | Escherichia coli K-12 | Kd | 2.3604 | 5 | 5 |
| Estrogen receptor | Rattus norvegicus (Norway rat) | EC50 | 150.0000 | 1 | 2 |
| Estrogen receptor beta | Rattus norvegicus (Norway rat) | EC50 | 150.0000 | 1 | 2 |
| LAP4 | Saccharomyces cerevisiae (brewer's yeast) | EC50 | 40.3177 | 3 | 4 |
| MEP2 | Saccharomyces cerevisiae (brewer's yeast) | EC50 | 182,505.0000 | 2 | 2 |
| mu opioid receptor, partial | Homo sapiens (human) | EC50 | 32.0000 | 1 | 1 |
| NS5 | Zika virus | EC50 | 0.0308 | 2 | 2 |
| Peroxisome proliferator-activated receptor alpha | Homo sapiens (human) | EC50 | 8.9000 | 3 | 3 |
| Peroxisome proliferator-activated receptor delta | Homo sapiens (human) | EC50 | 22.3400 | 1 | 1 |
| Peroxisome proliferator-activated receptor gamma | Homo sapiens (human) | EC50 | 26.9400 | 3 | 3 |
| Procathepsin L | Homo sapiens (human) | EC50 | 0.0325 | 1 | 2 |
| Replicase polyprotein 1a | Severe acute respiratory syndrome-related coronavirus | EC50 | 0.0325 | 1 | 2 |
| Replicase polyprotein 1ab | Betacoronavirus England 1 | EC50 | 0.0325 | 1 | 2 |
| Replicase polyprotein 1ab | Human coronavirus 229E | EC50 | 0.0325 | 1 | 2 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | EC50 | 0.0325 | 1 | 2 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | EC50 | 0.0325 | 1 | 2 |
| RPL19A | Saccharomyces cerevisiae (brewer's yeast) | EC50 | 14.7400 | 1 | 1 |
| Spike glycoprotein | Betacoronavirus England 1 | EC50 | 0.0325 | 1 | 2 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | EC50 | 0.0325 | 1 | 2 |
| streptokinase A precursor | Streptococcus pyogenes M1 GAS | EC50 | 76.9960 | 2 | 2 |
| Trace amine-associated receptor 1 | Homo sapiens (human) | EC50 | 10.0000 | 1 | 1 |
| Trace amine-associated receptor 1 | Mus musculus (house mouse) | EC50 | 5.4000 | 1 | 1 |
| Trace amine-associated receptor 5 | Mus musculus (house mouse) | EC50 | 10.0000 | 1 | 3 |
| Transient receptor potential cation channel subfamily A member 1 | Homo sapiens (human) | EC50 | 0.4900 | 1 | 1 |
| Transmembrane protease serine 2 | Homo sapiens (human) | EC50 | 0.0325 | 1 | 2 |
Other Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| aryl hydrocarbon receptor nuclear translocator | Homo sapiens (human) | AC50 | 7.4600 | 1 | 1 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | Km | 6.0000 | 1 | 1 |
| Beta-hexosaminidase subunit alpha | Homo sapiens (human) | Activity | 30.0000 | 1 | 1 |
| Carbonic anhydrase 1 | Homo sapiens (human) | Kinact | 6.6000 | 1 | 1 |
| Carbonic anhydrase 12 | Homo sapiens (human) | Kinact | 8.1000 | 1 | 1 |
| Carbonic anhydrase 13 | Mus musculus (house mouse) | Kinact | 4.9000 | 1 | 1 |
| Carbonic anhydrase 14 | Homo sapiens (human) | Kinact | 5.0000 | 1 | 1 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Kinact | 6.5000 | 1 | 1 |
| Carbonic anhydrase 3 | Homo sapiens (human) | Kinact | 3.3000 | 1 | 1 |
| Carbonic anhydrase 4 | Homo sapiens (human) | Kinact | 5.4000 | 1 | 1 |
| Carbonic anhydrase 5A, mitochondrial | Homo sapiens (human) | Kinact | 8.3000 | 1 | 1 |
| Carbonic anhydrase 6 | Homo sapiens (human) | Kinact | 5.3000 | 1 | 1 |
| Carbonic anhydrase 7 | Homo sapiens (human) | Kinact | 16.0000 | 1 | 1 |
| Carbonic anhydrase 9 | Homo sapiens (human) | Kinact | 5.6000 | 1 | 1 |
| Dihydrofolate reductase | Escherichia coli K-12 | Ratio | 0.0009 | 4 | 4 |
| Endothelial PAS domain-containing protein 1 | Homo sapiens (human) | MIC | 0.3000 | 1 | 1 |
| Estrogen receptor | Homo sapiens (human) | MEC | 1.0000 | 1 | 1 |
| Estrogen receptor beta | Homo sapiens (human) | MEC | 1.0000 | 1 | 1 |
| Glutathione reductase, mitochondrial | Homo sapiens (human) | Km | 160.0000 | 1 | 1 |
| heat shock protein 90, putative | Plasmodium falciparum 3D7 | AC50 | 0.4665 | 1 | 2 |
| heat shock protein HSP 90-alpha isoform 2 | Homo sapiens (human) | AC50 | 0.7745 | 1 | 2 |
| HSP40, subfamily A [Plasmodium falciparum 3D7] | Plasmodium falciparum 3D7 | AbsAC1000_uM | 0.6290 | 1 | 1 |
| Hypoxia-inducible factor 1-alpha | Homo sapiens (human) | MIC | 0.3000 | 1 | 1 |
| Nuclear receptor subfamily 1 group I member 2 | Homo sapiens (human) | MEC | 2.0000 | 1 | 2 |
| PAX8 | Homo sapiens (human) | AC50 | 4.8700 | 1 | 1 |
| Proteasome subunit beta type-1 | Homo sapiens (human) | Ki50 | 0.0250 | 2 | 2 |
| Proteasome subunit beta type-2 | Homo sapiens (human) | Ki50 | 1.0750 | 2 | 2 |
| Proteasome subunit beta type-5 | Homo sapiens (human) | Ki50 | 0.0100 | 2 | 2 |
| transforming acidic coiled-coil-containing protein 3 | Homo sapiens (human) | AC50 | 7.4600 | 1 | 1 |