Page last updated: 2024-08-05 15:16:19

antiprotozoal drug

Any antimicrobial drug which is used to treat or prevent protozoal infections.

ChEBI ID: 35820

Members (26)

MemberDefinitionClass
amphotericin bA macrolide antibiotic used to treat potentially life-threatening fungal infections.amphotericin B
ascochlorinA dihydroxybenzaldehyde that is 2,4-dihydroxybenzaldehyde which is substituted by a (1E,3E)-3-methyl-1-[(1R,2R,6R)-1,2,6-trimethyl-3-oxocyclohexyl]penta-1,3-dien-5-yl group at position 3, chlorine at position 5, and a methyl group at position 6. A meroterpenoid produced by several fungi including Ascochyta viciae . It exhibits anticancer, antifungal and antiprotozoal activities.ascochlorin
ascofuranoneA dihydroxybenzaldehyde that is 2,4-dihydroxybenzaldehyde which is substituted by a (2E,6E)-7-[(2S)-5,5-dimethyl-4-oxotetrahydrofuran-2-yl]-3-methylocta-2,6-dien-1-yl group at position 3, chlorine at position 5, and a methyl group at position 6. A meroterpenoid produced by the soil fungus, Acremonium sclerotigenum. It is a promising drug candidate against the tropical disease, African trypanosomiasis.ascofuranone
benzonidazoleA monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2-nitroimidazol-1-yl)acetic acid with the aromatic amino group of benzylamine. Used for treatment of Chagas disease.benznidazole
bortezomibL-Phenylalaninamide substituted at the amide nitrogen by a 1-(dihydroxyboranyl)-3-methylbutyl group and at N(alpha) by a pyrazin-2-ylcarbonyl group. It is a dipeptidyl boronic acid that reversibly inhibits the 26S proteasome.bortezomib
chlorquinaldolA monohydroxyquinoline that is quinolin-8-ol which is substituted by a methyl group at position 2 and by chlorine at positions 5 and 7. An antifungal and antibacterial, it was formerly used for topical treatment of skin conditions and vaginal infections.chlorquinaldol
clioquinolA monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 are replaced by chlorine and iodine, respectively. It has antibacterial and atifungal properties, and is used in creams for the treatment of skin infections. It has also been investigated as a chelator of copper and zinc ions for the possible treatment of Alzheimer's disease.5-chloro-7-iodoquinolin-8-ol
cycloguanilA triazine in which a 1,6-dihydro-1,3,5-triazine ring is substituted at N-1 by a 4-chlorophenyl group, at C-2 and -4 by amino groups and at C-6 by gem-dimethyl groups. A dihydrofolate reductase inhibitor, it is a metabolite of the antimalarial drug proguanil.cycloguanil
dehydroemetineA pyridoisoquinoline which was developed in response to the cardiovascular toxicity associated with emetine and results from the dehydrogenation of the heterotricylic ring of emetine. It is an antiprotozoal agent and displays antimalarial, antiamoebic, and antileishmanial properties.dehydroemetine
diallyl trisulfideAn organic trisulfide that is trisulfane in which both of the hydrogens are replaced by allyl groups. A component of the essential oil of garlic and a major component of the traditional Chinese medicine allitridium, it exhibits antifungal, antitumour and antioxidant activitydiallyl trisulfide
dimetridazoleA C-nitro compound that is 5-nitroimidazole in which the hydrogens at positions 1 and 2 are replaced by methyl groups. An antiprotozoal drug, it has been banned by both the Government of Canada and the European Union as a livestock feed additive owing to suspicions of it being carcinogenic.dimetridazole
emetineA pyridoisoquinoline comprising emetam having methoxy substituents at the 6'-, 7'-, 10- and 11-positions. It is an antiprotozoal agent and emetic. It inhibits SARS-CoV2, Zika and Ebola virus replication and displays antimalarial, antineoplastic and antiamoebic properties.emetine
emetine dihydrochlorideThe dihydrochloride salt of emetine.emetine dihydrochloride
fumagillinA meroterpenoid resulting from the formal condensation of the hydroxy group of fumagillol with the carboxylic acid group of (all-E)-deca-2,4,6,8-tetraenedioic acid. Originally isolated from the fungus Aspergillus fumigatus, it is used for the control of Nosema infection in honey bees.fumagillin
imidocarbimidocarb
iodoquinolA monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 are replaced by iodine. It is considered the drug of choice for treating asymptomatic or moderate forms of amoebiasis.iodoquinol
miltefosineA phospholipid that is the hexadecyl monoester of phosphocholine.miltefosine
nitarsoneAn organoarsonic acid where the organyl group is 4-nitrophenyl.nitarsone
ornidazoleA C-nitro compound that is 5-nitroimidazole in which the hydrogens at positions 1 and 2 are replaced by 3-chloro-2-hydroxypropyl and methyl groups, respectively. It is used in the treatment of susceptible protozoal infections and for the treatment of anaerobic bacterial infections.ornidazole
paromomycinAn amino cyclitol glycoside that is the 1-O-(2-amino-2-deoxy-alpha-D-glucopyranoside) and the 3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranoside of 4,6-diamino-2,3-dihydroxycyclohexane (the 1R,2R,3S,4R,6S diastereoisomer). It is obtained from various Streptomyces species. A broad-spectrum antibiotic, it is used (generally as the sulfate salt) for the treatment of acute and chronic intestinal protozoal infections, but is not effective for extraintestinal protozoal infections. It is also used as a therapeutic against visceral leishmaniasis.paromomycin
proguanilA biguanide compound which has isopropyl and p-chlorophenyl substituents on the terminal N atoms. A prophylactic antimalarial drug, it works by inhibiting the enzyme dihydrofolate reductase, which is involved in the reproduction of the malaria parasites Plasmodium falciparum and P. vivax within the red blood cells.proguanil
psi-baptigeninA member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone and in which the phenyl group at position 3 is replaced by a 1,3-benzodioxol-5-yl group.pseudobaptigenin
pyrimethamineAn aminopyrimidine that is pyrimidine-2,4-diamine which is substituted at position 5 by a p-chlorophenyl group and at position 6 by an ethyl group. It is a folic acid antagonist used as an antimalarial or with a sulfonamide to treat toxoplasmosis.pyrimethamine
ronidazoleA carbamate ester that is 5-nitroimidazole in which the hydrogens at positions 1 and 2 are replaced by methyl and (carbamoyloxy)methyl groups, respectively. An antiprotozoal agent, it is used in veterinary medicine for the treatment of histomoniasis and swine dysentery.ronidazole
sulfadiazineA sulfonamide consisting of pyrimidine with a 4-aminobenzenesulfonamido group at the 2-position.sulfadiazine
tinidazole1H-imidazole substituted at C-1 by a (2-ethylsulfonyl)ethyl group, at C-2 by a methyl group and at C-5 by a nitro group. It is used as an antiprotozoal, antibacterial agent.tinidazole

Research

Studies (39,331)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-199011,701 (29.75)18.7374
1990's4,999 (12.71)18.2507
2000's8,244 (20.96)29.6817
2010's11,112 (28.25)24.3611
2020's3,275 (8.33)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials3,380 (7.67%)5.53%
Reviews3,926 (8.90%)6.00%
Case Studies7,344 (16.65%)4.05%
Observational131 (0.30%)0.25%
Other29,315 (66.48%)84.16%

Protein Targets (414)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1Homo sapiens (human)Potency31.762613
15-lipoxygenase, partialHomo sapiens (human)Potency24.230813
67.9K proteinVaccinia virusPotency21.6862212
acetylcholinesteraseHomo sapiens (human)Potency0.776211
activating transcription factor 6Homo sapiens (human)Potency12.319524
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency26.590415
Alpha-synucleinHomo sapiens (human)Potency4.007512
apical membrane antigen 1, AMA1Plasmodium falciparum 3D7Potency1.778312
AR proteinHomo sapiens (human)Potency17.99171164
aryl hydrocarbon receptorHomo sapiens (human)Potency24.467137
ATAD5 protein, partialHomo sapiens (human)Potency11.400333
Ataxin-2Homo sapiens (human)Potency11.5588210
ATPase family AAA domain-containing protein 5Homo sapiens (human)Potency8.6678214
Bloom syndrome protein isoform 1Homo sapiens (human)Potency17.782822
bromodomain adjacent to zinc finger domain 2BHomo sapiens (human)Potency39.810711
caspase 7, apoptosis-related cysteine proteaseHomo sapiens (human)Potency34.505112
caspase-3Cricetulus griseus (Chinese hamster)Potency15.369012
caspase-3Homo sapiens (human)Potency34.505112
Caspase-7Cricetulus griseus (Chinese hamster)Potency15.369012
Cellular tumor antigen p53Homo sapiens (human)Potency14.8284325
cellular tumor antigen p53 isoform aHomo sapiens (human)Potency14.024727
Chain A, 2-oxoglutarate OxygenaseHomo sapiens (human)Potency27.211215
Chain A, Beta-lactamaseEscherichia coli K-12Potency8.484513
Chain A, CruzipainTrypanosoma cruziPotency21.990817
Chain A, Ferritin light chainEquus caballus (horse)Potency25.118911
Chain A, HADH2 proteinHomo sapiens (human)Potency32.184123
Chain A, JmjC domain-containing histone demethylation protein 3AHomo sapiens (human)Potency67.833412
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency32.945925
Chain A, TYROSYL-DNA PHOSPHODIESTERASEHomo sapiens (human)Potency19.678015
Chain B, HADH2 proteinHomo sapiens (human)Potency32.184123
chromobox protein homolog 1Homo sapiens (human)Potency86.339814
cytochrome P450 2D6Homo sapiens (human)Potency25.601812
cytochrome P450 2D6 isoform 1Homo sapiens (human)Potency8.971612
cytochrome P450 3A4 isoform 1Homo sapiens (human)Potency22.723729
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency15.6020210
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency13.762618
Disintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)Potency1.298813
DNA dC->dU-editing enzyme APOBEC-3F isoform aHomo sapiens (human)Potency14.348412
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency85.894313
estrogen nuclear receptor alphaHomo sapiens (human)Potency18.21361189
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency21.6727211
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency14.4991965
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency25.249616
EWS/FLI fusion proteinHomo sapiens (human)Potency2.692248
farnesoid X nuclear receptorHomo sapiens (human)Potency28.6621412
flap endonuclease 1Homo sapiens (human)Potency30.821214
Fumarate hydrataseHomo sapiens (human)Potency20.086314
GABA theta subunitRattus norvegicus (Norway rat)Potency23.613615
GALC proteinHomo sapiens (human)Potency0.707912
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)Potency23.613615
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)Potency23.613615
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)Potency23.613615
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)Potency23.613615
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)Potency23.613615
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)Potency23.613615
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)Potency23.613615
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)Potency23.613615
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)Potency23.613615
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)Potency23.613615
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)Potency23.613615
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)Potency23.613615
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)Potency23.613615
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)Potency23.613615
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)Potency23.613615
gemininHomo sapiens (human)Potency12.9259420
GLI family zinc finger 3Homo sapiens (human)Potency16.2225323
glp-1 receptor, partialHomo sapiens (human)Potency13.191114
GLS proteinHomo sapiens (human)Potency26.632012
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency12.0218417
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency25.0543111
Glycoprotein hormones alpha chainHomo sapiens (human)Potency3.162311
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)Homo sapiens (human)Potency40.990313
heat shock protein beta-1Homo sapiens (human)Potency7.449527
histone acetyltransferase KAT2A isoform 1Homo sapiens (human)Potency31.099012
Histone H2A.xCricetulus griseus (Chinese hamster)Potency37.7730214
huntingtin isoform 2Homo sapiens (human)Potency17.706714
hypoxia-inducible factor 1 alpha subunitHomo sapiens (human)Potency19.351816
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)Homo sapiens (human)Potency3.298837
IDH1Homo sapiens (human)Potency3.362414
importin subunit beta-1 isoform 1Homo sapiens (human)Potency44.668411
Integrin alpha-IIbHomo sapiens (human)Potency23.110313
Integrin beta-3Homo sapiens (human)Potency23.110313
Interferon betaHomo sapiens (human)Potency3.970329
interleukin 8Homo sapiens (human)Potency47.307911
lamin isoform A-delta10Homo sapiens (human)Potency5.7879213
LuciferasePhotinus pyralis (common eastern firefly)Potency40.533411
Microtubule-associated protein tauHomo sapiens (human)Potency23.819523
mitogen-activated protein kinase 1Homo sapiens (human)Potency22.749623
muscleblind-like protein 1 isoform 1Homo sapiens (human)Potency21.450912
neuropeptide S receptor isoform AHomo sapiens (human)Potency2.511911
nonstructural protein 1Influenza A virus (A/WSN/1933(H1N1))Potency4.227813
NPC intracellular cholesterol transporter 1 precursorHomo sapiens (human)Potency58.047911
Nrf2Homo sapiens (human)Potency22.387211
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency22.2373428
nuclear factor erythroid 2-related factor 2 isoform 2Homo sapiens (human)Potency12.047213
nuclear factor NF-kappa-B p105 subunit isoform 1Homo sapiens (human)Potency17.782811
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency33.620412
Nuclear receptor ROR-gammaHomo sapiens (human)Potency42.845813
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency1.1060212
nuclear receptor subfamily 1, group I, member 2Rattus norvegicus (Norway rat)Potency2.835414
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency16.9965328
parathyroid hormone/parathyroid hormone-related peptide receptor precursorHomo sapiens (human)Potency89.125111
ParkinHomo sapiens (human)Potency9.200011
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1Homo sapiens (human)Potency84.921411
peripheral myelin protein 22Rattus norvegicus (Norway rat)Potency11.087829
peripheral myelin protein 22 isoform 1Homo sapiens (human)Potency0.075711
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency22.2804522
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency29.4716514
phosphopantetheinyl transferaseBacillus subtilisPotency50.246214
plasminogen precursorMus musculus (house mouse)Potency0.707911
polyproteinZika virusPotency20.086314
polyunsaturated fatty acid lipoxygenase ALOX12Homo sapiens (human)Potency0.707911
potassium voltage-gated channel subfamily H member 2 isoform dHomo sapiens (human)Potency16.432416
PPM1D proteinHomo sapiens (human)Potency0.350014
pregnane X nuclear receptorHomo sapiens (human)Potency28.3045212
pregnane X receptorRattus norvegicus (Norway rat)Potency50.118711
progesterone receptorHomo sapiens (human)Potency9.157929
RAR-related orphan receptor gammaMus musculus (house mouse)Potency20.8349222
ras-related protein Rab-9AHomo sapiens (human)Potency18.356411
regulator of G-protein signaling 4Homo sapiens (human)Potency70.794611
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency26.6321321
retinoid X nuclear receptor alphaHomo sapiens (human)Potency8.7140311
serine/threonine-protein kinase mTOR isoform 1Homo sapiens (human)Potency3.530622
serine/threonine-protein kinase PLK1Homo sapiens (human)Potency23.778111
signal transducer and activator of transcription 6, interleukin-4 inducedHomo sapiens (human)Potency25.278333
SMAD family member 2Homo sapiens (human)Potency30.521422
SMAD family member 3Homo sapiens (human)Potency30.521422
Smad3Homo sapiens (human)Potency24.850214
snurportin-1Homo sapiens (human)Potency44.668411
Spike glycoproteinSevere acute respiratory syndrome-related coronavirusPotency24.569415
survival motor neuron protein isoform dHomo sapiens (human)Potency17.099018
TAR DNA-binding protein 43Homo sapiens (human)Potency23.780514
TDP1 proteinHomo sapiens (human)Potency7.9578232
thioredoxin glutathione reductaseSchistosoma mansoniPotency56.607212
thioredoxin reductaseRattus norvegicus (Norway rat)Potency34.309715
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency11.4308327
thyroid stimulating hormone receptorHomo sapiens (human)Potency26.714245
thyrotropin-releasing hormone receptorHomo sapiens (human)Potency26.972411
transcriptional regulator ERG isoform 3Homo sapiens (human)Potency11.220211
tumor necrosis factorHomo sapiens (human)Potency42.163211
ubiquitin carboxyl-terminal hydrolase 2 isoform aHomo sapiens (human)Potency1.298813
urokinase plasminogen activator surface receptor precursorMus musculus (house mouse)Potency0.707911
urokinase-type plasminogen activator precursorMus musculus (house mouse)Potency0.707911
USP1 protein, partialHomo sapiens (human)Potency59.621812
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency20.2120213
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency12.865549
vitamin D3 receptor isoform VDRAHomo sapiens (human)Potency38.846814
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency25.0543111
VprHuman immunodeficiency virus 1Potency10.000011

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
26S proteasome complex subunit SEM1Homo sapiens (human)IC500.533544
26S proteasome non-ATPase regulatory subunit 1Homo sapiens (human)IC500.533544
26S proteasome non-ATPase regulatory subunit 11Homo sapiens (human)IC500.533544
26S proteasome non-ATPase regulatory subunit 12Homo sapiens (human)IC500.533544
26S proteasome non-ATPase regulatory subunit 13Homo sapiens (human)IC500.533544
26S proteasome non-ATPase regulatory subunit 14Homo sapiens (human)IC500.533544
26S proteasome non-ATPase regulatory subunit 2Homo sapiens (human)IC500.533544
26S proteasome non-ATPase regulatory subunit 3Homo sapiens (human)IC500.533544
26S proteasome non-ATPase regulatory subunit 4Homo sapiens (human)IC500.533544
26S proteasome non-ATPase regulatory subunit 6Homo sapiens (human)IC500.533544
26S proteasome non-ATPase regulatory subunit 7Homo sapiens (human)IC500.533544
26S proteasome non-ATPase regulatory subunit 8Homo sapiens (human)IC500.533544
26S proteasome regulatory subunit 10BHomo sapiens (human)IC500.533544
26S proteasome regulatory subunit 4Homo sapiens (human)IC500.533544
26S proteasome regulatory subunit 6AHomo sapiens (human)IC500.533544
26S proteasome regulatory subunit 6BHomo sapiens (human)IC500.533544
26S proteasome regulatory subunit 7Homo sapiens (human)IC500.533544
26S proteasome regulatory subunit 8Homo sapiens (human)IC500.533544
30S ribosomal protein S1Escherichia coli K-12IC500.035522
30S ribosomal protein S10Escherichia coli K-12IC500.035522
30S ribosomal protein S11Escherichia coli K-12IC500.035522
30S ribosomal protein S12Escherichia coli K-12IC500.035522
30S ribosomal protein S13Escherichia coli K-12IC500.035522
30S ribosomal protein S14Escherichia coli K-12IC500.035522
30S ribosomal protein S15Escherichia coli K-12IC500.035522
30S ribosomal protein S16Escherichia coli K-12IC500.035522
30S ribosomal protein S17Escherichia coli K-12IC500.035522
30S ribosomal protein S18Escherichia coli K-12IC500.035522
30S ribosomal protein S19Escherichia coli K-12IC500.035522
30S ribosomal protein S2Escherichia coli K-12IC500.035522
30S ribosomal protein S20Escherichia coli K-12IC500.035522
30S ribosomal protein S21Escherichia coli K-12IC500.035522
30S ribosomal protein S3Escherichia coli K-12IC500.035522
30S ribosomal protein S4Escherichia coli K-12IC500.035522
30S ribosomal protein S5Escherichia coli K-12IC500.035522
30S ribosomal protein S6Escherichia coli K-12IC500.035522
30S ribosomal protein S7Escherichia coli K-12IC500.035522
30S ribosomal protein S8Escherichia coli K-12IC500.035522
30S ribosomal protein S9Escherichia coli K-12IC500.035522
50S ribosomal protein L1Escherichia coli K-12IC500.035522
50S ribosomal protein L10Escherichia coli K-12IC500.035522
50S ribosomal protein L11Escherichia coli K-12IC500.035522
50S ribosomal protein L13Escherichia coli K-12IC500.035522
50S ribosomal protein L14Escherichia coli K-12IC500.035522
50S ribosomal protein L15Escherichia coli K-12IC500.035522
50S ribosomal protein L16Escherichia coli K-12IC500.035522
50S ribosomal protein L17Escherichia coli K-12IC500.035522
50S ribosomal protein L18Escherichia coli K-12IC500.035522
50S ribosomal protein L19Escherichia coli K-12IC500.035522
50S ribosomal protein L2Escherichia coli K-12IC500.035522
50S ribosomal protein L20Escherichia coli K-12IC500.035522
50S ribosomal protein L21Escherichia coli K-12IC500.035522
50S ribosomal protein L22Escherichia coli K-12IC500.035522
50S ribosomal protein L23Escherichia coli K-12IC500.035522
50S ribosomal protein L24Escherichia coli K-12IC500.035522
50S ribosomal protein L25Escherichia coli K-12IC500.035522
50S ribosomal protein L27Escherichia coli K-12IC500.035522
50S ribosomal protein L28Escherichia coli K-12IC500.035522
50S ribosomal protein L29Escherichia coli K-12IC500.035522
50S ribosomal protein L3Escherichia coli K-12IC500.035522
50S ribosomal protein L30Escherichia coli K-12IC500.035522
50S ribosomal protein L31Escherichia coli K-12IC500.035522
50S ribosomal protein L31 type BEscherichia coli K-12IC500.035522
50S ribosomal protein L32Escherichia coli K-12IC500.035522
50S ribosomal protein L33Escherichia coli K-12IC500.035522
50S ribosomal protein L34Escherichia coli K-12IC500.035522
50S ribosomal protein L35Escherichia coli K-12IC500.035522
50S ribosomal protein L36Escherichia coli K-12IC500.035522
50S ribosomal protein L36 2Escherichia coli K-12IC500.035522
50S ribosomal protein L4Escherichia coli K-12IC500.035522
50S ribosomal protein L5Escherichia coli K-12IC500.035522
50S ribosomal protein L6Escherichia coli K-12IC500.035522
50S ribosomal protein L7/L12Escherichia coli K-12IC500.035522
90-kda heat shock protein beta HSP90 beta, partialHomo sapiens (human)IC5050.000011
AcetylcholinesteraseHomo sapiens (human)IC500.590011
Adenosine receptor A3Homo sapiens (human)IC500.933011
Adenosine receptor A3Homo sapiens (human)Ki0.527011
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)IC500.933011
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)Ki0.527011
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)IC500.933011
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)Ki0.527011
Alpha-2A adrenergic receptorHomo sapiens (human)IC500.038011
Alpha-2A adrenergic receptorHomo sapiens (human)Ki0.014011
Alpha-2C adrenergic receptorHomo sapiens (human)IC500.182011
Alpha-2C adrenergic receptorHomo sapiens (human)Ki0.026011
Alternative oxidase, mitochondrialTrypanosoma brucei bruceiIC500.002011
Alternative oxidase, mitochondrialTrypanosoma brucei bruceiKi0.000111
Amyloid-beta precursor proteinHomo sapiens (human)IC5039.866733
ATP-binding cassette sub-family C member 3Homo sapiens (human)IC50133.000017
ATP-dependent Clp protease proteolytic subunitStaphylococcus aureus subsp. aureus NCTC 8325IC505.300011
ATP-dependent translocase ABCB1Homo sapiens (human)IC5072.757177
Aurora kinase AHomo sapiens (human)IC5021.000011
Aurora kinase BHomo sapiens (human)IC50100.000013
Beta-carbonic anhydrase 1Mycobacterium tuberculosis H37RvKi7.300011
Beta-hexosaminidase subunit alphaHomo sapiens (human)IC5011.083366
Beta-hexosaminidase subunit betaHomo sapiens (human)IC5010.228677
Bifunctional dihydrofolate reductase-thymidylate synthaseCryptosporidium parvumIC501,000.000011
Bifunctional dihydrofolate reductase-thymidylate synthasePlasmodium falciparum 3D7IC502.480011
Bifunctional dihydrofolate reductase-thymidylate synthasePlasmodium falciparum K1IC5028.29881014
Bifunctional dihydrofolate reductase-thymidylate synthaseToxoplasma gondiiIC500.32171111
Bifunctional dihydrofolate reductase-thymidylate synthasePlasmodium falciparum 3D7Ki0.000811
Bifunctional dihydrofolate reductase-thymidylate synthasePlasmodium falciparum K1Ki0.26392340
Bifunctional dihydrofolate reductase-thymidylate synthasePlasmodium vivax (malaria parasite P. vivax)Ki0.001612
Bile salt export pumpHomo sapiens (human)IC50338.5462313
Botulinum neurotoxin type A Clostridium botulinumIC5015.200012
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)IC50122.500022
Calcium-dependent protein kinase 1Plasmodium falciparum 3D7IC501.000011
Calcium-dependent protein kinase 4Plasmodium falciparum 3D7IC501.000011
cAMP-specific 3',5'-cyclic phosphodiesterase 4DHomo sapiens (human)IC5010.000022
Canalicular multispecific organic anion transporter 1Homo sapiens (human)IC50133.000017
Carbonic anhydrase 1Homo sapiens (human)IC5012.720313
Carbonic anhydrase 1Homo sapiens (human)Ki1.290022
Carbonic anhydrase 12Homo sapiens (human)Ki5.870011
Carbonic anhydrase 13Homo sapiens (human)Ki8.450011
Carbonic anhydrase 14Homo sapiens (human)Ki3.280011
Carbonic anhydrase 15Mus musculus (house mouse)Ki2.505022
Carbonic anhydrase 2Homo sapiens (human)IC5012.720313
Carbonic anhydrase 2Homo sapiens (human)Ki1.160022
Carbonic anhydrase 3Homo sapiens (human)Ki4.570011
Carbonic anhydrase 4Homo sapiens (human)Ki6.510011
Carbonic anhydrase 5A, mitochondrialHomo sapiens (human)Ki6.920011
Carbonic anhydrase 5B, mitochondrialHomo sapiens (human)Ki6.830011
Carbonic anhydrase 6Homo sapiens (human)IC5012.720313
Carbonic anhydrase 6Homo sapiens (human)Ki4.380011
Carbonic anhydrase 7Homo sapiens (human)Ki6.940011
Carbonic anhydrase 9Homo sapiens (human)Ki3.380011
Catechol O-methyltransferaseRattus norvegicus (Norway rat)IC505.204912
Cathepsin BHomo sapiens (human)IC5030.000011
Cathepsin GHomo sapiens (human)IC501.810022
Cathepsin GHomo sapiens (human)Ki0.630011
Cdk-related protein kinase 6Plasmodium falciparum (malaria parasite P. falciparum)IC501.000011
cGMP-dependent 3',5'-cyclic phosphodiesteraseHomo sapiens (human)IC5039.650012
Chain H, Proteasome component PUP1Saccharomyces cerevisiae (brewer's yeast)Ki0.000611
Chain I, Proteasome component PUP3Saccharomyces cerevisiae (brewer's yeast)Ki0.000611
Chain K, Proteasome component PRE2Saccharomyces cerevisiae (brewer's yeast)Ki0.000612
Chain L, Proteasome component C5Saccharomyces cerevisiae (brewer's yeast)Ki0.000612
ChymaseHomo sapiens (human)IC501.190011
Chymotrypsinogen ABos taurus (cattle)Ki2.400011
Chymotrypsinogen BHomo sapiens (human)Ki0.320011
Cyclin-dependent kinase 1Homo sapiens (human)IC501,000.000011
Cytochrome P450 1A2Homo sapiens (human)IC50100.000013
Cytochrome P450 2C19Homo sapiens (human)IC5098.666713
Cytochrome P450 2C9 Homo sapiens (human)IC50100.000013
Cytochrome P450 2C9 Homo sapiens (human)Ki51.500011
Cytochrome P450 2D6Homo sapiens (human)IC5092.600013
Cytochrome P450 3A4Homo sapiens (human)IC5099.400013
delta-type opioid receptorHomo sapiens (human)IC5032.000011
Dihydrofolate reductaseCandida albicansIC505.000011
Dihydrofolate reductaseEscherichia coli K-12IC509.836733
Dihydrofolate reductaseHomo sapiens (human)IC503.105777
Dihydrofolate reductasePneumocystis cariniiIC502.938989
Dihydrofolate reductaseRattus norvegicus (Norway rat)IC501.90921112
Dihydrofolate reductaseEscherichia coli K-12Ki0.223066
Dihydrofolate reductaseGallus gallus (chicken)Ki0.112211
Dihydrofolate reductaseHomo sapiens (human)Ki3.70921012
Dihydrofolate reductaseLacticaseibacillus caseiKi17.378011
Dihydrofolate reductasePneumocystis cariniiKi27.285734
Dihydrofolate reductase Bos taurus (cattle)IC500.100722
Dihydroorotate dehydrogenase Leishmania majorIC501,037.000012
Dihydroorotate dehydrogenase (quinone), mitochondrialHomo sapiens (human)IC503.350012
Dipeptidyl peptidase 4Homo sapiens (human)IC500.390011
dual specificity protein phosphatase 3Homo sapiens (human)IC5080.000022
Endothelial PAS domain-containing protein 1Homo sapiens (human)IC500.096522
Epidermal growth factor receptorHomo sapiens (human)IC501.889011
Fatty acid synthaseGallus gallus (chicken)IC508.370022
Glucose transporterLeishmania mexicanaIC506.040512
Glyceraldehyde-3-phosphate dehydrogenaseHomo sapiens (human)IC5050.000011
heat shock protein HSP 90-alpha isoform 2Homo sapiens (human)IC5050.000011
Hexose transporter 1 Plasmodium falciparum (malaria parasite P. falciparum)IC506.045012
Histone deacetylase 1Homo sapiens (human)IC5066.3880215
Histone deacetylase 11 Homo sapiens (human)IC5071.0857114
Histone deacetylase 2Homo sapiens (human)IC5066.4000215
Histone deacetylase 3Homo sapiens (human)IC5066.4253215
Histone deacetylase 4Homo sapiens (human)IC5071.0857114
Histone deacetylase 5Homo sapiens (human)IC5071.0857114
Histone deacetylase 6Homo sapiens (human)IC5070.9760215
Histone deacetylase 7Homo sapiens (human)IC5071.0857114
Histone deacetylase 8Homo sapiens (human)IC5066.3515215
Histone deacetylase 9Homo sapiens (human)IC5071.0857114
Hypoxia-inducible factor 1-alphaHomo sapiens (human)IC500.096522
kappa-type opioid receptor isoform 1Homo sapiens (human)IC5018.895022
Lon protease homolog, mitochondrialHomo sapiens (human)IC500.183011
Low molecular weight phosphotyrosine protein phosphataseHomo sapiens (human)IC5015.615022
low molecular weight phosphotyrosine protein phosphatase isoform cHomo sapiens (human)IC5028.250022
Lysine--tRNA ligase Plasmodium falciparum 3D7IC502.500011
Lysosomal protective proteinHomo sapiens (human)IC509.200011
M-phase inducer phosphatase 1Homo sapiens (human)IC5025.000011
Methionine aminopeptidaseEscherichia coli K-12IC50100.000011
Methionine aminopeptidase 1Saccharomyces cerevisiae S288CIC50100.000011
Methionine aminopeptidase 2Homo sapiens (human)IC500.008244
Mitogen-activated protein kinase Plasmodium falciparum (malaria parasite P. falciparum)IC501.000011
Mitogen-activated protein kinase 1Homo sapiens (human)IC500.294011
Mitogen-activated protein kinase 14Homo sapiens (human)IC500.364011
Mitogen-activated protein kinase 3 Homo sapiens (human)IC505.264011
Multidrug and toxin extrusion protein 1Mus musculus (house mouse)Ki0.145011
Multidrug resistance-associated protein 4Homo sapiens (human)IC50133.000017
NACHT, LRR and PYD domains-containing protein 3 Mus musculus (house mouse)IC500.040711
Neutrophil elastaseHomo sapiens (human)Ki2.300011
Nuclear factor NF-kappa-B p100 subunit Homo sapiens (human)IC500.085011
Nuclear factor NF-kappa-B p105 subunitHomo sapiens (human)IC500.085011
Platelet-activating factor receptorCavia porcellus (domestic guinea pig)IC50200.000011
Polyamine deacetylase HDAC10Homo sapiens (human)IC5071.0857114
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)IC50100.000013
Proline--tRNA ligasePlasmodium falciparum 3D7IC502.500011
Proteasomal ubiquitin receptor ADRM1Homo sapiens (human)IC500.533544
Proteasome subunit alpha type-1Homo sapiens (human)IC500.321377
Proteasome subunit alpha type-2Homo sapiens (human)IC500.321377
Proteasome subunit alpha type-3Homo sapiens (human)IC500.321377
Proteasome subunit alpha type-4Homo sapiens (human)IC500.321377
Proteasome subunit alpha type-5Homo sapiens (human)IC500.321377
Proteasome subunit alpha type-6Homo sapiens (human)IC500.321377
Proteasome subunit alpha type-7Homo sapiens (human)IC500.321377
Proteasome subunit alpha-type 8Homo sapiens (human)IC500.321377
Proteasome subunit beta type-1Homo sapiens (human)IC500.21491818
Proteasome subunit beta type-10Homo sapiens (human)IC500.53591010
Proteasome subunit beta type-11Homo sapiens (human)IC500.321377
Proteasome subunit beta type-2Homo sapiens (human)IC502.98601919
Proteasome subunit beta type-3Homo sapiens (human)IC500.321377
Proteasome subunit beta type-4Homo sapiens (human)IC500.321377
Proteasome subunit beta type-5Homo sapiens (human)IC5015,084.28363234
Proteasome subunit beta type-5Homo sapiens (human)Ki0.006733
Proteasome subunit beta type-6Homo sapiens (human)IC500.284288
Proteasome subunit beta type-7Homo sapiens (human)IC501.877288
Proteasome subunit beta type-8Homo sapiens (human)IC500.16811414
Proteasome subunit beta type-8Mus musculus (house mouse)IC500.016811
Proteasome subunit beta type-9Homo sapiens (human)IC500.20591111
Protein kinase domain-containing proteinPlasmodium falciparum (malaria parasite P. falciparum)IC501.000011
ProthrombinHomo sapiens (human)Ki13.000011
Pteridine reductase 1Leishmania majorIC5013.600011
RAC-alpha serine/threonine-protein kinaseHomo sapiens (human)IC509.600011
Receptor tyrosine-protein kinase erbB-2Homo sapiens (human)IC508.577011
Serine hydrolase RBBP9Homo sapiens (human)IC507.800011
Solute carrier family 2, facilitated glucose transporter member 1Homo sapiens (human)IC506.054012
Solute carrier family 22 member 1Mus musculus (house mouse)Ki3.600011
Solute carrier family 22 member 1 Homo sapiens (human)IC5013.570011
Spike glycoproteinSevere acute respiratory syndrome coronavirus 2IC505.600011
Substance-K receptorRattus norvegicus (Norway rat)Ki0.071711
Transcription factor p65Homo sapiens (human)IC500.085011
Tyrosine-protein kinase FynHomo sapiens (human)IC501.571011
Tyrosine-protein kinase LckHomo sapiens (human)IC502.461011
tyrosine-protein phosphatase non-receptor type 22 isoform 1Homo sapiens (human)IC5080.000022
Tyrosyl-DNA phosphodiesterase 1Homo sapiens (human)IC5021,000.000011

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)EC5031.500011
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)EC5031.500011
Alpha-1D adrenergic receptorRattus norvegicus (Norway rat)EC5031.500011
Angiotensin-converting enzyme 2 Homo sapiens (human)EC500.032512
ATP-dependent Clp protease proteolytic subunitStaphylococcus aureus subsp. aureus NCTC 8325EC5023.500011
Beta-galactosidaseEscherichia coliEC5031.500011
citrate synthase 2, partialSaccharomyces cerevisiae (brewer's yeast)EC50166.300011
delta-type opioid receptorHomo sapiens (human)EC5032.000011
Dihydrofolate reductaseEscherichia coli K-12Kd2.360455
Estrogen receptorRattus norvegicus (Norway rat)EC50150.000012
Estrogen receptor betaRattus norvegicus (Norway rat)EC50150.000012
LAP4Saccharomyces cerevisiae (brewer's yeast)EC5040.317734
MEP2Saccharomyces cerevisiae (brewer's yeast)EC50182,505.000022
mu opioid receptor, partialHomo sapiens (human)EC5032.000011
NS5 Zika virusEC500.030822
Peroxisome proliferator-activated receptor alphaHomo sapiens (human)EC508.900033
Peroxisome proliferator-activated receptor deltaHomo sapiens (human)EC5022.340011
Peroxisome proliferator-activated receptor gammaHomo sapiens (human)EC5026.940033
Procathepsin LHomo sapiens (human)EC500.032512
Replicase polyprotein 1aSevere acute respiratory syndrome-related coronavirusEC500.032512
Replicase polyprotein 1abBetacoronavirus England 1EC500.032512
Replicase polyprotein 1abHuman coronavirus 229EEC500.032512
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2EC500.032512
Replicase polyprotein 1abSevere acute respiratory syndrome-related coronavirusEC500.032512
RPL19ASaccharomyces cerevisiae (brewer's yeast)EC5014.740011
Spike glycoproteinBetacoronavirus England 1EC500.032512
Spike glycoproteinSevere acute respiratory syndrome-related coronavirusEC500.032512
streptokinase A precursorStreptococcus pyogenes M1 GASEC5076.996022
Trace amine-associated receptor 1Homo sapiens (human)EC5010.000011
Trace amine-associated receptor 1Mus musculus (house mouse)EC505.400011
Trace amine-associated receptor 5Mus musculus (house mouse)EC5010.000013
Transient receptor potential cation channel subfamily A member 1Homo sapiens (human)EC500.490011
Transmembrane protease serine 2Homo sapiens (human)EC500.032512

Other Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
aryl hydrocarbon receptor nuclear translocatorHomo sapiens (human)AC507.460011
ATP-dependent translocase ABCB1Homo sapiens (human)Km6.000011
Beta-hexosaminidase subunit alphaHomo sapiens (human)Activity30.000011
Carbonic anhydrase 1Homo sapiens (human)Kinact6.600011
Carbonic anhydrase 12Homo sapiens (human)Kinact8.100011
Carbonic anhydrase 13Mus musculus (house mouse)Kinact4.900011
Carbonic anhydrase 14Homo sapiens (human)Kinact5.000011
Carbonic anhydrase 2Homo sapiens (human)Kinact6.500011
Carbonic anhydrase 3Homo sapiens (human)Kinact3.300011
Carbonic anhydrase 4Homo sapiens (human)Kinact5.400011
Carbonic anhydrase 5A, mitochondrialHomo sapiens (human)Kinact8.300011
Carbonic anhydrase 6Homo sapiens (human)Kinact5.300011
Carbonic anhydrase 7Homo sapiens (human)Kinact16.000011
Carbonic anhydrase 9Homo sapiens (human)Kinact5.600011
Dihydrofolate reductaseEscherichia coli K-12Ratio0.000944
Endothelial PAS domain-containing protein 1Homo sapiens (human)MIC0.300011
Estrogen receptorHomo sapiens (human)MEC1.000011
Estrogen receptor betaHomo sapiens (human)MEC1.000011
Glutathione reductase, mitochondrialHomo sapiens (human)Km160.000011
heat shock protein 90, putativePlasmodium falciparum 3D7AC500.466512
heat shock protein HSP 90-alpha isoform 2Homo sapiens (human)AC500.774512
HSP40, subfamily A [Plasmodium falciparum 3D7]Plasmodium falciparum 3D7AbsAC1000_uM0.629011
Hypoxia-inducible factor 1-alphaHomo sapiens (human)MIC0.300011
Nuclear receptor subfamily 1 group I member 2Homo sapiens (human)MEC2.000012
PAX8Homo sapiens (human)AC504.870011
Proteasome subunit beta type-1Homo sapiens (human)Ki500.025022
Proteasome subunit beta type-2Homo sapiens (human)Ki501.075022
Proteasome subunit beta type-5Homo sapiens (human)Ki500.010022
transforming acidic coiled-coil-containing protein 3Homo sapiens (human)AC507.460011