ascorbic-acid and Disseminated-Intravascular-Coagulation

The analysis of the literature on communication of a hemostasis and vitamin C has allowed to assert, that its deficiency accelerates lipid peroxidation and reduces potential at porpoises, and it conducts to activation platelets, to acceleration of continuous intravascular blood coagulation of and to reduction in tolerance to thrombin. High dozes of vitamin C influences a hemostasis strengthens lipid peroxidation similarly to prooxidizers. Entering high dozes of vitamin C at the statuses menacing weith thromboses, it is desirable to supervise a level of markers of intravascular blood coagulation in plasma.

Topics: Animals; Ascorbic Acid; Ascorbic Acid Deficiency; Blood Coagulation; Blood Platelets; Disseminated Intravascular Coagulation; Homeostasis; Humans; Lipid Peroxidation; Platelet Activation; Thrombin; Thrombosis

Lyophilized plasma (LP) is as safe and effective as fresh frozen plasma (FFP) for resuscitation after severe trauma.. Multicenter animal study.. Animal laboratories, 2 level I trauma centers.. Thirty-two Yorkshire crossbred swine.. Lyophilized plasma was analyzed for factor levels and clotting activity before lyophilization and after reconstitution. Swine were subjected to complex multiple trauma including extremity fracture, hemorrhage, severe liver injury, acidosis, and hypothermia. They were then resuscitated with FFP, LP, FFP and packed red blood cells (PRBCs) in a ratio of 1:1, or 1:1 LP and PRBCs.. Residual clotting activity of LP after reconstitution, swine mortality, hemodynamic measures, total blood loss, coagulation profiles, and inflammatory measures.. Lyophilization decreased clotting factor activity by an average of 14%. Survival and heart rate were similar between all groups. Swine resuscitated with LP had equivalent or higher mean arterial pressures. Swine treated with LP had similar coagulation profiles, plasma lactate levels, and postinjury blood loss compared with those treated with FFP. Swine treated with 1:1 FFP-PRBCs were similar to those treated with 1:1 LP-PRBCs. Resuscitation with LP resulted in a reduction in postresuscitation interleukin 6 expression compared with resuscitation with FFP.. The process of lyophilization and reconstitution of plasma reduces coagulation factor activity by 14%, without acute differences in blood loss. Lyophilized plasma can be used for resuscitation in a severe multiple trauma and hemorrhagic shock swine model with efficacy equal to that of FFP and with decreased interleukin 6 production.

Topics: Animals; Antioxidants; Ascorbic Acid; Disease Models, Animal; Disseminated Intravascular Coagulation; Fluid Therapy; Freeze Drying; Plasma; Plasma Substitutes; Resuscitation; Shock, Hemorrhagic; Swine; Wounds and Injuries

Topics: Adult; Aged; Anticoagulants; Ascorbic Acid; Atropine; Autopsy; Disseminated Intravascular Coagulation; Female; Glucocorticoids; Humans; Iatrogenic Disease; Male; Middle Aged; Peptic Ulcer; Peptic Ulcer Hemorrhage; Reserpine; Respiration, Artificial; Resuscitation