Page last updated: 2024-08-05 14:50:28
MRI contrast agent
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ChEBI ID: 37335
Members (5)
| Member | Definition | Class |
|---|---|---|
| dimethyl sulfoxide | A 2-carbon sulfoxide in which the sulfur atom has two methyl substituents. | dimethyl sulfoxide |
| gadolinium dtpa | gadopentetate | |
| gadoteridol | A non-ionic gadolinium chelate having a macrocyclic tetraamine framework. It is used as a paramagnetic contrast agent in magnetic resonance imaging (MRI). | gadoteridol |
| manganese chloride | A hydrate that is the tetrahydrate form of manganese(II) chloride. | manganese(II) chloride tetrahydrate |
| tempo carboxylic acid | A member of the class of aminoxyls that is TEMPO carrying a carboxy group at position 4. | 4-carboxy-TEMPO |
Research
Studies (26,208)
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 6,154 (23.48) | 18.7374 |
| 1990's | 5,359 (20.45) | 18.2507 |
| 2000's | 6,501 (24.81) | 29.6817 |
| 2010's | 6,577 (25.10) | 24.3611 |
| 2020's | 1,617 (6.17) | 2.80 |
Study Types
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 960 (3.38%) | 5.53% |
| Reviews | 1,042 (3.66%) | 6.00% |
| Case Studies | 1,896 (6.67%) | 4.05% |
| Observational | 81 (0.28%) | 0.25% |
| Other | 24,464 (86.01%) | 84.16% |
Protein Targets (10)
Potency Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 18.0161 | 3 | 3 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 68.5896 | 2 | 2 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 61.1306 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 61.5362 | 2 | 2 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 19,952.6000 | 1 | 1 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 0.0138 | 1 | 1 |
Inhibition Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Cereblon isoform 4 | Magnetospirillum gryphiswaldense | IC50 | 20.8000 | 1 | 1 |
| Cereblon isoform 4 | Magnetospirillum gryphiswaldense | Ki | 5,570.2333 | 3 | 3 |
| Choline O-acetyltransferase | Rattus norvegicus (Norway rat) | Ki | 25,000.0000 | 1 | 1 |
| Protein cereblon | Homo sapiens (human) | IC50 | 264.0000 | 1 | 1 |
| Protein cereblon | Homo sapiens (human) | Ki | 68,568.5000 | 2 | 2 |
Activation Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Insulin-like growth factor-binding protein 5 | Homo sapiens (human) | Kd | 696,000.0000 | 7 | 7 |