neurotransmitter

An endogenous compound that is used to transmit information across the synapse between a neuron and another cell.

ChEBI ID: 25512

Members (17)

Member	Definition	Class
3-tyramine	A primary amino compound that is 2-phenylethanamine substituted by a hydroxy group at position 3.	m-tyramine
5-hydroxytryptophan	A tryptophan derivative that is tryptophan substituted by a hydroxy group at position 5.	5-hydroxytryptophan
anandamide	An N-acylethanolamine 20:4 resulting from the formal condensation of carboxy group of arachidonic acid with the amino group of ethanolamine.	anandamide
aspartic acid	The L-enantiomer of aspartic acid.	L-aspartic acid
beta-alanine	A naturally-occurring beta-amino acid comprising propionic acid with the amino group in the 3-position.	beta-alanine zwitterion; beta-alanine
carbon monoxide	A one-carbon compound in which the carbon is joined only to a single oxygen. It is a colourless, odourless, tasteless, toxic gas.	carbon monoxide
choline	A choline that is the parent compound of the cholines class, consisting of ethanolamine having three methyl substituents attached to the amino function.	choline
enkephalin, leucine	A pentapeptide comprising L-tyrosine, glycine, glycine, L-phenylalanine and L-leucine residues joined in sequence by peptide linkages. It is an endogenous opioid peptide produced in vertebrate species, including rodents, primates and humans that results from decomposition of proenkephalin or dynorphin and exhibits antinociceptive properties.	Leu-enkephalin zwitterion; Leu-enkephalin
gamma-aminobutyric acid	A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.	gamma-aminobutyric acid zwitterion; gamma-aminobutyric acid
glutamic acid	An optically active form of glutamic acid having L-configuration.	L-glutamic acid
glycine	The simplest (and the only achiral) proteinogenic amino acid, with a hydrogen atom as its side chain.	glycine zwitterion; glycine
histamine	A member of the class of imidazoles that is 1H-imidazole substituted at position C-4 by a 2-aminoethyl group.	histamine
neurotensin	A 13 amino acid peptide hormone which is found in the central nervous system and the gastrointestinal tract. It behaves as a neurotransmitter in the brain, as a hormone in the gut, and also as a neuromodulator. It is implicated in the pathophysiology of several CNS disorders (including schizophrenia, Parkinson's disease, drug abuse, pain, cancer, inflammation, eating disorders and central control of blood pressure) due to its association with a wide variety of neurotransmitter systems such as dopaminergic, sertonergic, glutamatergic, GABAergic, and cholinergic systems.	neurotensin
octopamine	A member of the class of phenylethanolamines that is phenol which is substituted at the para- position by a 2-amino-1-hydroxyethyl group. A biogenic phenylethanolamine which has been found to act as a neurotransmitter, neurohormone or neuromodulator in invertebrates.	octopamine
pterostilbene	A stilbenol that consists of trans-stilbene bearing a hydroxy group at position 4 as well as two methoxy substituents at positions 3' and 5'.	pterostilbene
substance p	A neuropeptide consisting of 11-amino acids. It preferentially activates neurokinin-1 receptors, exterting excitatory effects on central and peripheral neurons and involved in pain transmission.	substance P
tyramine	A primary amino compound obtained by formal decarboxylation of the amino acid tyrosine.	tyramine

Research

Studies (233,160)

Timeframe	Studies, Drugs with This Role(%)	All Drugs %
pre-1990	82,111 (35.22)	18.7374
1990's	45,750 (19.62)	18.2507
2000's	49,038 (21.03)	29.6817
2010's	43,525 (18.67)	24.3611
2020's	12,736 (5.46)	2.80

Study Types

Publication Type	Studies, Drugs with this Role (%)	All Drugs (%)
Trials	6,698 (2.51%)	5.53%
Reviews	17,464 (6.54%)	6.00%
Case Studies	4,616 (1.73%)	4.05%
Observational	260 (0.10%)	0.25%
Other	238,098 (89.13%)	84.16%

Protein Targets (404)

Potency Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
aldehyde dehydrogenase 1 family, member A1	Homo sapiens (human)	Potency	24.6335	1	4
apical membrane antigen 1, AMA1	Plasmodium falciparum 3D7	Potency	5.0119	1	1
AR protein	Homo sapiens (human)	Potency	23.7681	3	4
arylsulfatase A	Homo sapiens (human)	Potency	6.0158	1	3
ATAD5 protein, partial	Homo sapiens (human)	Potency	1.4575	1	2
ATP-dependent phosphofructokinase	Trypanosoma brucei brucei TREU927	Potency	19.0512	1	2
beta-2 adrenergic receptor	Homo sapiens (human)	Potency	20.5962	1	1
Bloom syndrome protein isoform 1	Homo sapiens (human)	Potency	8.5169	2	5
BRCA1	Homo sapiens (human)	Potency	17.7828	1	1
bromodomain adjacent to zinc finger domain 2B	Homo sapiens (human)	Potency	40.0319	1	2
Chain A, 2-oxoglutarate Oxygenase	Homo sapiens (human)	Potency	30.3001	1	2
Chain A, Beta-lactamase	Escherichia coli K-12	Potency	3,162.2800	1	1
Chain A, Ferritin light chain	Equus caballus (horse)	Potency	29.4592	2	4
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	Homo sapiens (human)	Potency	22.7170	1	2
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	Homo sapiens (human)	Potency	76.1104	1	2
cytochrome P450 2C19 precursor	Homo sapiens (human)	Potency	32.4648	1	2
cytochrome P450 2D6	Homo sapiens (human)	Potency	13.8029	1	1
cytochrome P450 family 3 subfamily A polypeptide 4	Homo sapiens (human)	Potency	27.5404	1	1
D(1A) dopamine receptor	Homo sapiens (human)	Potency	4.1092	1	1
D(3) dopamine receptor isoform e	Homo sapiens (human)	Potency	28.1838	1	1
DNA polymerase iota isoform a (long)	Homo sapiens (human)	Potency	89.1251	1	1
DNA polymerase kappa isoform 1	Homo sapiens (human)	Potency	30.5015	1	2
dopamine D1 receptor	Homo sapiens (human)	Potency	14.3978	1	2
estrogen nuclear receptor alpha	Homo sapiens (human)	Potency	19.5160	3	3
euchromatic histone-lysine N-methyltransferase 2	Homo sapiens (human)	Potency	9.7241	1	10
EWS/FLI fusion protein	Homo sapiens (human)	Potency	14.6921	2	2
GALC protein	Homo sapiens (human)	Potency	0.7079	1	1
geminin	Homo sapiens (human)	Potency	2.5836	2	3
glp-1 receptor, partial	Homo sapiens (human)	Potency	7.1060	2	2
GLS protein	Homo sapiens (human)	Potency	8.4139	2	6
glucocorticoid receptor [Homo sapiens]	Homo sapiens (human)	Potency	6.3735	1	2
Histamine H2 receptor	Cavia porcellus (domestic guinea pig)	Potency	0.1413	1	2
histone acetyltransferase KAT2A isoform 1	Homo sapiens (human)	Potency	39.8107	1	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	Homo sapiens (human)	Potency	0.0794	1	1
Inositol monophosphatase 1	Rattus norvegicus (Norway rat)	Potency	31.6228	1	2
lamin isoform A-delta10	Homo sapiens (human)	Potency	10.5010	2	4
lethal factor (plasmid)	Bacillus anthracis str. A2012	Potency	6.9241	1	2
lethal(3)malignant brain tumor-like protein 1 isoform I	Homo sapiens (human)	Potency	12.5893	1	1
Luciferase	Photinus pyralis (common eastern firefly)	Potency	13.4591	1	1
lysosomal alpha-glucosidase preproprotein	Homo sapiens (human)	Potency	11.2202	1	1
M-phase phosphoprotein 8	Homo sapiens (human)	Potency	37.6858	1	1
Microtubule-associated protein tau	Homo sapiens (human)	Potency	11.2202	1	1
mitogen-activated protein kinase 1	Homo sapiens (human)	Potency	39.8107	1	1
muscarinic acetylcholine receptor M1	Rattus norvegicus (Norway rat)	Potency	8.9165	1	2
neuropeptide S receptor isoform A	Homo sapiens (human)	Potency	31.6228	1	1
NPC intracellular cholesterol transporter 1 precursor	Homo sapiens (human)	Potency	2.5119	1	1
nuclear receptor ROR-gamma isoform 1	Mus musculus (house mouse)	Potency	6.4468	2	2
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Homo sapiens (human)	Potency	8.4921	1	1
peripheral myelin protein 22	Rattus norvegicus (Norway rat)	Potency	8.0970	1	2
phosphopantetheinyl transferase	Bacillus subtilis	Potency	32.4517	1	7
Polyunsaturated fatty acid lipoxygenase ALOX15B	Homo sapiens (human)	Potency	0.1413	1	1
potassium voltage-gated channel subfamily H member 2 isoform d	Homo sapiens (human)	Potency	28.1838	1	1
ras-related protein Rab-9A	Homo sapiens (human)	Potency	3.1623	1	1
regulator of G-protein signaling 4	Homo sapiens (human)	Potency	1.6233	1	9
retinoid X nuclear receptor alpha	Homo sapiens (human)	Potency	16.9301	2	2
TAR DNA-binding protein 43	Homo sapiens (human)	Potency	31.8326	1	2
TDP1 protein	Homo sapiens (human)	Potency	18.3688	2	5
thioredoxin reductase	Rattus norvegicus (Norway rat)	Potency	14.8118	2	4
thyroid hormone receptor beta isoform 2	Rattus norvegicus (Norway rat)	Potency	33.4915	1	1
thyroid hormone receptor beta isoform a	Homo sapiens (human)	Potency	41.5242	1	2
thyroid stimulating hormone receptor	Homo sapiens (human)	Potency	31.6228	2	3
transcriptional regulator ERG isoform 3	Homo sapiens (human)	Potency	1.1220	1	1
USP1 protein, partial	Homo sapiens (human)	Potency	44.6684	1	1
vitamin D3 receptor isoform VDRA	Homo sapiens (human)	Potency	70.7946	1	1

Inhibition Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
Acetylcholinesterase	Homo sapiens (human)	IC50	3,013.0100	1	1
Alpha-1A adrenergic receptor	Rattus norvegicus (Norway rat)	Ki	0.0720	1	1
Alpha-ketoglutarate-dependent dioxygenase FTO	Homo sapiens (human)	IC50	1,000.0000	1	1
ATP-citrate synthase	Rattus norvegicus (Norway rat)	Ki	300.0000	1	1
ATP-dependent translocase ABCB1	Homo sapiens (human)	IC50	42.0000	1	1
Bifunctional aspartokinase/homoserine dehydrogenase 1	Escherichia coli K-12	Ki	38,000.0000	1	2
Bile salt export pump	Homo sapiens (human)	IC50	1,000.0000	1	1
Breakpoint cluster region protein	Homo sapiens (human)	IC50	10.0000	1	1
Cannabinoid receptor 1	Homo sapiens (human)	Ki	0.1834	22	23
Cannabinoid receptor 1	Mus musculus (house mouse)	Ki	1.8470	3	3
Cannabinoid receptor 1	Rattus norvegicus (Norway rat)	Ki	0.6393	11	12
Cannabinoid receptor 2	Mus musculus (house mouse)	Ki	0.5260	2	2
Cannabinoid receptor 2	Rattus norvegicus (Norway rat)	Ki	0.5393	3	3
Cannabinoid receptor 2	Homo sapiens (human)	Ki	0.2699	10	11
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	Escherichia coli	Ki	15.0000	1	1
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	Rattus norvegicus (Norway rat)	IC50	0.8210	1	2
Chain B, Glutamate Receptor Subunit 2	Rattus norvegicus (Norway rat)	IC50	0.8210	1	1
Corticotropin-releasing factor receptor 2	Homo sapiens (human)	Ki	0.1680	1	1
Cytochrome P450 1A1	Homo sapiens (human)	Ki	0.5700	1	2
Cytochrome P450 1B1	Homo sapiens (human)	Ki	0.9100	1	1
Cytochrome P450 3A4	Homo sapiens (human)	IC50	2,818.3800	1	1
D(1A) dopamine receptor	Homo sapiens (human)	Ki	219.0000	1	4
D(2) dopamine receptor	Homo sapiens (human)	Ki	90.0000	1	2
Delta-type opioid receptor	Mus musculus (house mouse)	IC50	0.0142	5	7
Delta-type opioid receptor	Homo sapiens (human)	Ki	0.0062	7	9
Delta-type opioid receptor	Mus musculus (house mouse)	Ki	0.0046	3	3
Delta-type opioid receptor	Rattus norvegicus (Norway rat)	Ki	0.0032	4	4
Excitatory amino acid transporter 1	Homo sapiens (human)	IC50	82.6667	5	11
Excitatory amino acid transporter 1	Homo sapiens (human)	Ki	33.3114	1	2
Excitatory amino acid transporter 2	Homo sapiens (human)	IC50	48.5752	3	7
Excitatory amino acid transporter 2	Homo sapiens (human)	Ki	62.5478	1	2
Excitatory amino acid transporter 3	Homo sapiens (human)	IC50	33.9961	2	6
Excitatory amino acid transporter 3	Homo sapiens (human)	Ki	25.0848	1	2
Excitatory amino acid transporter 4	Rattus norvegicus (Norway rat)	IC50	12.1228	2	6
Fatty acid-binding protein, liver	Mus musculus (house mouse)	Ki	0.1110	1	1
Fatty-acid amide hydrolase 1	Homo sapiens (human)	IC50	3.7500	2	2
Fatty-acid amide hydrolase 1	Rattus norvegicus (Norway rat)	IC50	11.7490	1	1
Fatty-acid amide hydrolase 1	Homo sapiens (human)	Ki	10.0000	1	1
Fatty-acid amide hydrolase 1	Rattus norvegicus (Norway rat)	Ki	0.2850	2	2
GABA theta subunit	Rattus norvegicus (Norway rat)	IC50	0.0333	9	11
GABA theta subunit	Rattus norvegicus (Norway rat)	Ki	700.0247	3	3
Gamma-aminobutyric acid receptor subunit alpha-1	Rattus norvegicus (Norway rat)	IC50	0.0333	9	11
Gamma-aminobutyric acid receptor subunit alpha-1	Homo sapiens (human)	Ki	0.1165	2	2
Gamma-aminobutyric acid receptor subunit alpha-1	Rattus norvegicus (Norway rat)	Ki	700.0247	3	3
Gamma-aminobutyric acid receptor subunit alpha-2	Rattus norvegicus (Norway rat)	IC50	0.0323	9	12
Gamma-aminobutyric acid receptor subunit alpha-2	Homo sapiens (human)	Ki	0.1165	2	2
Gamma-aminobutyric acid receptor subunit alpha-2	Rattus norvegicus (Norway rat)	Ki	700.0247	3	3
Gamma-aminobutyric acid receptor subunit alpha-3	Rattus norvegicus (Norway rat)	IC50	0.0333	9	11
Gamma-aminobutyric acid receptor subunit alpha-3	Homo sapiens (human)	Ki	0.1165	2	2
Gamma-aminobutyric acid receptor subunit alpha-3	Rattus norvegicus (Norway rat)	Ki	700.0247	3	3
Gamma-aminobutyric acid receptor subunit alpha-4	Rattus norvegicus (Norway rat)	IC50	0.0333	9	11
Gamma-aminobutyric acid receptor subunit alpha-4	Homo sapiens (human)	Ki	0.1165	2	2
Gamma-aminobutyric acid receptor subunit alpha-4	Rattus norvegicus (Norway rat)	Ki	700.0247	3	3
Gamma-aminobutyric acid receptor subunit alpha-5	Rattus norvegicus (Norway rat)	IC50	0.0333	9	11
Gamma-aminobutyric acid receptor subunit alpha-5	Homo sapiens (human)	Ki	0.1165	2	2
Gamma-aminobutyric acid receptor subunit alpha-5	Rattus norvegicus (Norway rat)	Ki	700.0247	3	3
Gamma-aminobutyric acid receptor subunit alpha-6	Rattus norvegicus (Norway rat)	IC50	0.0333	9	11
Gamma-aminobutyric acid receptor subunit alpha-6	Homo sapiens (human)	Ki	0.1165	2	2
Gamma-aminobutyric acid receptor subunit alpha-6	Rattus norvegicus (Norway rat)	Ki	700.0247	3	3
Gamma-aminobutyric acid receptor subunit beta-1	Rattus norvegicus (Norway rat)	IC50	0.0333	9	11
Gamma-aminobutyric acid receptor subunit beta-1	Homo sapiens (human)	Ki	0.1165	2	2
Gamma-aminobutyric acid receptor subunit beta-1	Rattus norvegicus (Norway rat)	Ki	700.0247	3	3
Gamma-aminobutyric acid receptor subunit beta-2	Rattus norvegicus (Norway rat)	IC50	0.0333	9	11
Gamma-aminobutyric acid receptor subunit beta-2	Homo sapiens (human)	Ki	0.1165	2	2
Gamma-aminobutyric acid receptor subunit beta-2	Rattus norvegicus (Norway rat)	Ki	700.0247	3	3
Gamma-aminobutyric acid receptor subunit beta-3	Rattus norvegicus (Norway rat)	IC50	0.0333	9	11
Gamma-aminobutyric acid receptor subunit beta-3	Homo sapiens (human)	Ki	0.1165	2	2
Gamma-aminobutyric acid receptor subunit beta-3	Rattus norvegicus (Norway rat)	Ki	700.0247	3	3
Gamma-aminobutyric acid receptor subunit delta	Rattus norvegicus (Norway rat)	IC50	0.0333	9	11
Gamma-aminobutyric acid receptor subunit delta	Homo sapiens (human)	Ki	0.1165	2	2
Gamma-aminobutyric acid receptor subunit delta	Rattus norvegicus (Norway rat)	Ki	700.0247	3	3
Gamma-aminobutyric acid receptor subunit epsilon	Rattus norvegicus (Norway rat)	IC50	0.0333	9	11
Gamma-aminobutyric acid receptor subunit epsilon	Homo sapiens (human)	Ki	0.1165	2	2
Gamma-aminobutyric acid receptor subunit epsilon	Rattus norvegicus (Norway rat)	Ki	700.0247	3	3
Gamma-aminobutyric acid receptor subunit gamma-1	Rattus norvegicus (Norway rat)	IC50	0.0333	10	12
Gamma-aminobutyric acid receptor subunit gamma-1	Homo sapiens (human)	Ki	0.1165	2	2
Gamma-aminobutyric acid receptor subunit gamma-1	Rattus norvegicus (Norway rat)	Ki	700.0247	3	3
Gamma-aminobutyric acid receptor subunit gamma-2	Rattus norvegicus (Norway rat)	IC50	0.0333	9	11
Gamma-aminobutyric acid receptor subunit gamma-2	Homo sapiens (human)	Ki	0.1165	2	2
Gamma-aminobutyric acid receptor subunit gamma-2	Rattus norvegicus (Norway rat)	Ki	700.0247	3	3
Gamma-aminobutyric acid receptor subunit gamma-3	Rattus norvegicus (Norway rat)	IC50	0.0333	9	11
Gamma-aminobutyric acid receptor subunit gamma-3	Homo sapiens (human)	Ki	0.1165	2	2
Gamma-aminobutyric acid receptor subunit gamma-3	Rattus norvegicus (Norway rat)	Ki	700.0247	3	3
Gamma-aminobutyric acid receptor subunit pi	Rattus norvegicus (Norway rat)	IC50	0.0333	9	11
Gamma-aminobutyric acid receptor subunit pi	Homo sapiens (human)	Ki	0.1165	2	2
Gamma-aminobutyric acid receptor subunit pi	Rattus norvegicus (Norway rat)	Ki	700.0247	3	3
Gamma-aminobutyric acid receptor subunit theta	Homo sapiens (human)	Ki	0.1165	2	2
Gamma-aminobutyric acid type B receptor subunit 1	Rattus norvegicus (Norway rat)	IC50	0.0292	4	4
Gamma-aminobutyric acid type B receptor subunit 2	Rattus norvegicus (Norway rat)	IC50	0.0292	4	4
Glutamate carboxypeptidase 2	Homo sapiens (human)	IC50	428.0000	2	2
Glutamate receptor 1	Homo sapiens (human)	IC50	0.6130	1	1
Glutamate receptor 1	Rattus norvegicus (Norway rat)	IC50	0.5885	4	4
Glutamate receptor 1	Homo sapiens (human)	Ki	1.3607	3	3
Glutamate receptor 1	Rattus norvegicus (Norway rat)	Ki	0.6345	2	2
Glutamate receptor 2	Homo sapiens (human)	IC50	0.6130	1	1
Glutamate receptor 2	Rattus norvegicus (Norway rat)	IC50	0.5885	4	4
Glutamate receptor 2	Homo sapiens (human)	Ki	0.9400	3	3
Glutamate receptor 2	Rattus norvegicus (Norway rat)	Ki	0.4452	4	5
Glutamate receptor 3	Homo sapiens (human)	IC50	0.6130	1	1
Glutamate receptor 3	Rattus norvegicus (Norway rat)	IC50	0.5885	4	4
Glutamate receptor 3	Rattus norvegicus (Norway rat)	Ki	2.3122	4	4
Glutamate receptor 4	Homo sapiens (human)	IC50	0.6130	1	1
Glutamate receptor 4	Rattus norvegicus (Norway rat)	IC50	0.5885	4	4
Glutamate receptor 4	Homo sapiens (human)	Ki	0.8680	3	3
Glutamate receptor 4	Rattus norvegicus (Norway rat)	Ki	0.7270	2	2
Glutamate receptor ionotropic, kainate 1	Rattus norvegicus (Norway rat)	IC50	0.3800	3	5
Glutamate receptor ionotropic, kainate 1	Homo sapiens (human)	Ki	0.7010	2	2
Glutamate receptor ionotropic, kainate 1	Rattus norvegicus (Norway rat)	Ki	0.1284	5	7
Glutamate receptor ionotropic, kainate 2	Rattus norvegicus (Norway rat)	IC50	0.3800	3	5
Glutamate receptor ionotropic, kainate 2	Homo sapiens (human)	Ki	1.1060	2	2
Glutamate receptor ionotropic, kainate 2	Rattus norvegicus (Norway rat)	Ki	0.9566	7	9
Glutamate receptor ionotropic, kainate 3	Rattus norvegicus (Norway rat)	IC50	0.3800	3	5
Glutamate receptor ionotropic, kainate 3	Homo sapiens (human)	Ki	0.7890	2	2
Glutamate receptor ionotropic, kainate 3	Rattus norvegicus (Norway rat)	Ki	0.4201	4	6
Glutamate receptor ionotropic, kainate 4	Rattus norvegicus (Norway rat)	IC50	0.3800	3	5
Glutamate receptor ionotropic, kainate 4	Rattus norvegicus (Norway rat)	Ki	0.0630	1	1
Glutamate receptor ionotropic, kainate 5	Rattus norvegicus (Norway rat)	IC50	0.3800	3	5
Glutamate receptor ionotropic, kainate 5	Homo sapiens (human)	Ki	0.7337	3	3
Glutamate receptor ionotropic, kainate 5	Rattus norvegicus (Norway rat)	Ki	0.0630	1	1
Glutamate receptor ionotropic, NMDA 1	Homo sapiens (human)	IC50	0.0700	2	2
Glutamate receptor ionotropic, NMDA 1	Rattus norvegicus (Norway rat)	IC50	2.7397	10	12
Glutamate receptor ionotropic, NMDA 1	Rattus norvegicus (Norway rat)	Ki	7.3057	6	7
Glutamate receptor ionotropic, NMDA 2A	Homo sapiens (human)	IC50	0.0700	2	2
Glutamate receptor ionotropic, NMDA 2A	Rattus norvegicus (Norway rat)	IC50	1.6474	8	9
Glutamate receptor ionotropic, NMDA 2A	Rattus norvegicus (Norway rat)	Ki	7.3057	6	7
Glutamate receptor ionotropic, NMDA 2B	Homo sapiens (human)	IC50	0.0700	2	2
Glutamate receptor ionotropic, NMDA 2B	Rattus norvegicus (Norway rat)	IC50	1.6474	8	9
Glutamate receptor ionotropic, NMDA 2B	Rattus norvegicus (Norway rat)	Ki	7.3057	6	7
Glutamate receptor ionotropic, NMDA 2C	Homo sapiens (human)	IC50	0.0700	2	2
Glutamate receptor ionotropic, NMDA 2C	Rattus norvegicus (Norway rat)	IC50	1.6474	8	9
Glutamate receptor ionotropic, NMDA 2C	Rattus norvegicus (Norway rat)	Ki	7.3057	6	7
Glutamate receptor ionotropic, NMDA 2D	Homo sapiens (human)	IC50	0.0700	2	2
Glutamate receptor ionotropic, NMDA 2D	Rattus norvegicus (Norway rat)	IC50	1.6474	8	9
Glutamate receptor ionotropic, NMDA 2D	Rattus norvegicus (Norway rat)	Ki	7.3057	6	7
Glutamate receptor ionotropic, NMDA 3A	Homo sapiens (human)	IC50	0.0700	2	2
Glutamate receptor ionotropic, NMDA 3A	Rattus norvegicus (Norway rat)	IC50	1.6474	8	9
Glutamate receptor ionotropic, NMDA 3A	Rattus norvegicus (Norway rat)	Ki	7.3057	6	7
Glutamate receptor ionotropic, NMDA 3B	Homo sapiens (human)	IC50	0.0700	2	2
Glutamate receptor ionotropic, NMDA 3B	Rattus norvegicus (Norway rat)	IC50	1.6474	8	9
Glutamate receptor ionotropic, NMDA 3B	Rattus norvegicus (Norway rat)	Ki	7.3057	6	7
Glutaminyl-peptide cyclotransferase	Homo sapiens (human)	Ki	850.0000	1	1
Glutathione reductase, mitochondrial	Homo sapiens (human)	IC50	53.7000	1	1
Glutathione reductase, mitochondrial	Homo sapiens (human)	Ki	42.7000	1	1
guanine nucleotide-binding protein subunit alpha-15	Homo sapiens (human)	IC50	29.9020	1	1
High affinity choline transporter 1	Mus musculus (house mouse)	IC50	1.6000	1	1
Histamine H1 receptor	Homo sapiens (human)	IC50	0.1585	1	2
Histamine H1 receptor	Rattus norvegicus (Norway rat)	IC50	0.1585	1	3
Histamine H1 receptor	Cavia porcellus (domestic guinea pig)	Ki	12.5892	1	1
Histamine H1 receptor	Homo sapiens (human)	Ki	1,440,809,206.6944	11	11
Histamine H1 receptor	Rattus norvegicus (Norway rat)	Ki	15,848,900,000.0000	1	1
Histamine H2 receptor	Homo sapiens (human)	Ki	13.7162	7	7
Histamine H3 receptor	Cavia porcellus (domestic guinea pig)	Ki	0.0001	1	1
Histamine H3 receptor	Homo sapiens (human)	Ki	0.0801	16	16
Histamine H3 receptor	Mus musculus (house mouse)	Ki	0.0680	1	1
Histamine H4 receptor	Homo sapiens (human)	Ki	0.0144	18	18
Histamine H4 receptor	Mus musculus (house mouse)	Ki	0.0607	2	2
Histamine H4 receptor	Rattus norvegicus (Norway rat)	Ki	0.0996	2	2
Histamine H4 receptor	Cavia porcellus (domestic guinea pig)	Ki	0.0060	1	1
Histamine N-methyltransferase	Rattus norvegicus (Norway rat)	Ki	0.0144	1	1
Histone deacetylase 1	Homo sapiens (human)	Ki	8.1900	1	1
Histone deacetylase 11	Homo sapiens (human)	Ki	8.1900	1	1
Histone deacetylase 2	Homo sapiens (human)	Ki	8.1900	1	1
Histone deacetylase 3	Homo sapiens (human)	Ki	8.1900	1	1
Histone deacetylase 4	Homo sapiens (human)	Ki	8.1900	1	1
Histone deacetylase 5	Homo sapiens (human)	Ki	8.1900	1	1
Histone deacetylase 6	Homo sapiens (human)	Ki	8.1900	1	1
Histone deacetylase 7	Homo sapiens (human)	Ki	8.1900	1	1
Histone deacetylase 8	Homo sapiens (human)	Ki	8.1900	1	1
Histone deacetylase 9	Homo sapiens (human)	Ki	8.1900	1	1
Kappa-type opioid receptor	Mus musculus (house mouse)	IC50	0.0417	2	2
Kappa-type opioid receptor	Cavia porcellus (domestic guinea pig)	Ki	10.0000	1	2
Kappa-type opioid receptor	Homo sapiens (human)	Ki	1.0000	1	1
Kappa-type opioid receptor	Rattus norvegicus (Norway rat)	Ki	10.0000	1	2
Lanosterol 14-alpha demethylase	Homo sapiens (human)	IC50	200.0000	1	1
Large neutral amino acids transporter small subunit 1	Homo sapiens (human)	IC50	200.0000	1	1
Macrophage migration inhibitory factor	Homo sapiens (human)	IC50	73.6000	1	1
Macrophage migration inhibitory factor	Homo sapiens (human)	Ki	62.0000	1	1
Metabotropic glutamate receptor 1	Homo sapiens (human)	Ki	3.6067	3	3
Metabotropic glutamate receptor 1	Rattus norvegicus (Norway rat)	Ki	0.3400	1	1
Metabotropic glutamate receptor 2	Homo sapiens (human)	Ki	7.6500	4	4
Metabotropic glutamate receptor 3	Homo sapiens (human)	Ki	9.0000	1	1
Metabotropic glutamate receptor 4	Homo sapiens (human)	Ki	5.6000	4	4
Metabotropic glutamate receptor 4	Rattus norvegicus (Norway rat)	Ki	3.4000	2	2
Metabotropic glutamate receptor 5	Homo sapiens (human)	Ki	4.3167	3	3
Metabotropic glutamate receptor 5	Rattus norvegicus (Norway rat)	Ki	0.0052	1	1
Metabotropic glutamate receptor 6	Homo sapiens (human)	Ki	38.0000	1	1
Metabotropic glutamate receptor 7	Homo sapiens (human)	Ki	5,400.0000	1	1
Metabotropic glutamate receptor 8	Homo sapiens (human)	IC50	0.0057	1	1
Metabotropic glutamate receptor 8	Homo sapiens (human)	Ki	9.5000	1	1
Metabotropic glutamate receptor 8	Rattus norvegicus (Norway rat)	Ki	3.4000	2	2
Mu-type opioid receptor	Cavia porcellus (domestic guinea pig)	IC50	0.2460	1	1
Mu-type opioid receptor	Homo sapiens (human)	IC50	9.5000	1	1
Mu-type opioid receptor	Mus musculus (house mouse)	IC50	0.0308	3	4
Mu-type opioid receptor	Cavia porcellus (domestic guinea pig)	Ki	0.3800	1	1
Mu-type opioid receptor	Danio rerio (zebrafish)	Ki	1.3170	1	1
Mu-type opioid receptor	Homo sapiens (human)	Ki	1.2148	3	4
Mu-type opioid receptor	Rattus norvegicus (Norway rat)	Ki	0.0143	3	3
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	Homo sapiens (human)	Ki	600.0000	1	1
NACHT, LRR and PYD domains-containing protein 3	Mus musculus (house mouse)	IC50	10.0000	1	1
Neuromedin-K receptor	Homo sapiens (human)	IC50	0.1250	1	1
Neuronal acetylcholine receptor subunit alpha-10	Rattus norvegicus (Norway rat)	Ki	42.0000	1	2
Neuronal acetylcholine receptor subunit alpha-2	Rattus norvegicus (Norway rat)	Ki	34.0000	2	3
Neuronal acetylcholine receptor subunit alpha-3	Rattus norvegicus (Norway rat)	Ki	42.2500	3	4
Neuronal acetylcholine receptor subunit alpha-4	Rattus norvegicus (Norway rat)	IC50	0.8200	1	1
Neuronal acetylcholine receptor subunit alpha-4	Rattus norvegicus (Norway rat)	Ki	38.7500	3	4
Neuronal acetylcholine receptor subunit alpha-5	Rattus norvegicus (Norway rat)	Ki	42.0000	1	2
Neuronal acetylcholine receptor subunit alpha-6	Rattus norvegicus (Norway rat)	Ki	42.0000	1	2
Neuronal acetylcholine receptor subunit alpha-7	Rattus norvegicus (Norway rat)	Ki	42.0000	1	2
Neuronal acetylcholine receptor subunit alpha-9	Rattus norvegicus (Norway rat)	Ki	42.0000	1	2
Neuronal acetylcholine receptor subunit beta-2	Rattus norvegicus (Norway rat)	IC50	0.8200	1	1
Neuronal acetylcholine receptor subunit beta-2	Rattus norvegicus (Norway rat)	Ki	35.2000	4	5
Neuronal acetylcholine receptor subunit beta-3	Rattus norvegicus (Norway rat)	Ki	42.0000	1	2
Neuronal acetylcholine receptor subunit beta-4	Rattus norvegicus (Norway rat)	Ki	41.5000	3	4
Neurotensin receptor type 1	Homo sapiens (human)	IC50	0.0013	11	11
Neurotensin receptor type 1	Homo sapiens (human)	Ki	0.0017	6	6
Neurotensin receptor type 1	Rattus norvegicus (Norway rat)	Ki	0.0014	2	2
Neurotensin receptor type 2	Rattus norvegicus (Norway rat)	IC50	0.0582	3	3
Neurotensin receptor type 2	Homo sapiens (human)	Ki	0.0046	3	3
Neurotensin receptor type 2	Rattus norvegicus (Norway rat)	Ki	0.0226	3	3
Opioid receptor homologue	Danio rerio (zebrafish)	Ki	0.0730	1	1
Opioid receptor, delta 1b	Danio rerio (zebrafish)	Ki	0.1750	1	1
Phenylethanolamine N-methyltransferase	Bos taurus (cattle)	Ki	772.0000	1	2
Polyamine deacetylase HDAC10	Homo sapiens (human)	Ki	8.1900	1	1
Polyunsaturated fatty acid 5-lipoxygenase	Homo sapiens (human)	IC50	4.5867	3	3
Potassium channel subfamily K member 2	Bos taurus (cattle)	IC50	1.0000	1	1
Potassium channel subfamily K member 3	Homo sapiens (human)	IC50	3.0000	1	1
Prolyl 4-hydroxylase	Paramecium bursaria Chlorella virus 1	IC50	1,000.0000	1	1
Prostaglandin G/H synthase 1	Homo sapiens (human)	IC50	0.7000	1	1
Prostaglandin G/H synthase 2	Homo sapiens (human)	IC50	0.8200	1	1
Proton-coupled amino acid transporter 1	Homo sapiens (human)	Ki	3,833.3333	1	3
Ribosyldihydronicotinamide dehydrogenase [quinone]	Homo sapiens (human)	IC50	5.1000	1	1
Serine racemase	Homo sapiens (human)	Ki	366.0000	1	1
Sodium- and chloride-dependent betaine transporter	Homo sapiens (human)	IC50	15.8771	30	57
Sodium- and chloride-dependent betaine transporter	Mus musculus (house mouse)	IC50	331.1310	1	1
Sodium- and chloride-dependent betaine transporter	Rattus norvegicus (Norway rat)	IC50	0.0200	1	1
Sodium- and chloride-dependent creatine transporter 1	Rattus norvegicus (Norway rat)	IC50	1.6000	1	1
Sodium- and chloride-dependent GABA transporter 1	Homo sapiens (human)	IC50	5.2623	4	5
Sodium- and chloride-dependent GABA transporter 1	Mus musculus (house mouse)	IC50	933.5483	6	9
Sodium- and chloride-dependent GABA transporter 1	Rattus norvegicus (Norway rat)	IC50	2.1520	5	15
Sodium- and chloride-dependent GABA transporter 2	Homo sapiens (human)	IC50	111.6667	3	3
Sodium- and chloride-dependent GABA transporter 2	Mus musculus (house mouse)	IC50	477.0552	5	8
Sodium- and chloride-dependent GABA transporter 2	Rattus norvegicus (Norway rat)	IC50	2.5100	2	2
Sodium- and chloride-dependent GABA transporter 3	Homo sapiens (human)	IC50	15.6259	6	7
Sodium- and chloride-dependent GABA transporter 3	Mus musculus (house mouse)	IC50	223.9832	4	7
Sodium- and chloride-dependent GABA transporter 3	Rattus norvegicus (Norway rat)	IC50	0.0200	1	1
Sodium- and chloride-dependent glycine transporter 1	Homo sapiens (human)	IC50	68.8000	2	2
Sodium- and chloride-dependent glycine transporter 2	Homo sapiens (human)	IC50	128.0000	1	1
Sodium- and chloride-dependent taurine transporter	Homo sapiens (human)	IC50	354.0000	1	1
Solute carrier family 22 member 1	Mus musculus (house mouse)	IC50	55.0000	1	1
Solute carrier family 22 member 1	Rattus norvegicus (Norway rat)	IC50	925.0000	2	2
Solute carrier family 22 member 1	Rattus norvegicus (Norway rat)	Ki	770.5000	2	2
Solute carrier family 22 member 2	Mus musculus (house mouse)	IC50	217.0000	1	1
Solute carrier family 22 member 2	Rattus norvegicus (Norway rat)	IC50	804.5000	2	2
Solute carrier family 22 member 2	Rattus norvegicus (Norway rat)	Ki	280.5000	2	2
Solute carrier family 22 member 3	Homo sapiens (human)	Ki	140.0000	1	1
Sortilin	Homo sapiens (human)	IC50	0.3600	1	1
Substance-K receptor	Homo sapiens (human)	IC50	0.2455	1	1
Substance-K receptor	Mesocricetus auratus (golden hamster)	IC50	0.1480	1	1
Substance-K receptor	Rattus norvegicus (Norway rat)	IC50	0.2000	1	1
Substance-K receptor	Homo sapiens (human)	Ki	0.1020	1	1
Substance-K receptor	Oryctolagus cuniculus (rabbit)	Ki	0.1020	1	2
Substance-P receptor	Homo sapiens (human)	IC50	0.0011	8	8
Substance-P receptor	Rattus norvegicus (Norway rat)	IC50	0.0005	4	4
Substance-P receptor	Cavia porcellus (domestic guinea pig)	Ki	0.0505	1	1
Substance-P receptor	Homo sapiens (human)	Ki	0.0016	1	1
Substance-P receptor	Rattus norvegicus (Norway rat)	Ki	0.0011	1	1
trace amine-associated receptor 1	Homo sapiens (human)	IC50	0.8818	1	1
Transient receptor potential cation channel subfamily A member 1	Rattus norvegicus (Norway rat)	IC50	7.5000	1	1
Transient receptor potential cation channel subfamily V member 1	Homo sapiens (human)	IC50	10.0000	1	1
Transient receptor potential cation channel subfamily V member 2	Rattus norvegicus (Norway rat)	IC50	4.7800	2	2
Tyrosine-protein kinase ABL1	Homo sapiens (human)	IC50	10.0000	1	1

Activation Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
5-hydroxytryptamine receptor 1A	Rattus norvegicus (Norway rat)	Kd	8.5114	1	2
5-hydroxytryptamine receptor 1B	Rattus norvegicus (Norway rat)	Kd	8.5114	1	2
5-hydroxytryptamine receptor 1D	Rattus norvegicus (Norway rat)	Kd	8.5114	1	2
5-hydroxytryptamine receptor 1F	Rattus norvegicus (Norway rat)	Kd	8.5114	1	2
5-hydroxytryptamine receptor 2A	Rattus norvegicus (Norway rat)	Kd	8.5114	1	2
5-hydroxytryptamine receptor 2B	Rattus norvegicus (Norway rat)	Kd	8.3220	2	3
5-hydroxytryptamine receptor 2C	Rattus norvegicus (Norway rat)	Kd	8.5114	1	2
5-hydroxytryptamine receptor 3A	Homo sapiens (human)	EC50	13.0120	1	2
5-hydroxytryptamine receptor 3A	Rattus norvegicus (Norway rat)	Kd	8.5114	1	2
5-hydroxytryptamine receptor 3B	Rattus norvegicus (Norway rat)	Kd	8.5114	1	2
5-hydroxytryptamine receptor 4	Rattus norvegicus (Norway rat)	Kd	8.5114	1	2
5-hydroxytryptamine receptor 5A	Rattus norvegicus (Norway rat)	Kd	8.5114	1	2
5-hydroxytryptamine receptor 5B	Rattus norvegicus (Norway rat)	Kd	8.5114	1	2
5-hydroxytryptamine receptor 6	Rattus norvegicus (Norway rat)	Kd	8.5114	1	2
5-hydroxytryptamine receptor 7	Rattus norvegicus (Norway rat)	Kd	8.5114	1	2
Beta-secretase 1	Homo sapiens (human)	Kd	2,000.0000	1	1
Cannabinoid receptor 1	Rattus norvegicus (Norway rat)	EC50	11.9039	3	4
Chain A, Acetylcholinesterase	Mus musculus (house mouse)	Kd	930.0000	1	7
Chain A, CARBONIC ANHYDRASE II	Homo sapiens (human)	Kd	125.0000	1	1
Chain A, Choline-binding protein	Bacillus subtilis subsp. subtilis str. JH642	Kd	30.5000	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	Bacillus subtilis	Kd	28.0000	1	4
Chain A, Protein (female-specific Histamine Binding Protein 2)	Rhipicephalus appendiculatus	Kd	0.0017	1	1
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein	Sinorhizobium meliloti	Kd	2.3000	1	2
Chain A, Slr1257 protein	Synechocystis sp. PCC 6803 substr. Kazusa	Kd	0.2400	1	1
D(2) dopamine receptor	Rattus norvegicus (Norway rat)	EC50	0.0010	1	1
Delta-type opioid receptor	Homo sapiens (human)	EC50	0.0246	7	8
Delta-type opioid receptor	Mus musculus (house mouse)	EC50	0.0740	1	1
Fatty acid-binding protein 5	Mus musculus (house mouse)	Kd	0.1003	1	1
Gamma-aminobutyric acid	Mus musculus (house mouse)	EC50	14.3000	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	Homo sapiens (human)	EC50	20.7620	9	13
Gamma-aminobutyric acid receptor subunit alpha-1	Mus musculus (house mouse)	EC50	14.3000	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	Rattus norvegicus (Norway rat)	EC50	6.1500	2	2
Gamma-aminobutyric acid receptor subunit alpha-2	Homo sapiens (human)	EC50	10.1514	6	8
Gamma-aminobutyric acid receptor subunit alpha-2	Mus musculus (house mouse)	EC50	14.3000	1	1
Gamma-aminobutyric acid receptor subunit alpha-3	Homo sapiens (human)	EC50	8.7818	6	8
Gamma-aminobutyric acid receptor subunit alpha-3	Mus musculus (house mouse)	EC50	14.3000	1	1
Gamma-aminobutyric acid receptor subunit alpha-4	Homo sapiens (human)	EC50	16.0009	5	6
Gamma-aminobutyric acid receptor subunit alpha-4	Mus musculus (house mouse)	EC50	14.3000	1	1
Gamma-aminobutyric acid receptor subunit alpha-5	Homo sapiens (human)	EC50	7.0091	5	6
Gamma-aminobutyric acid receptor subunit alpha-5	Mus musculus (house mouse)	EC50	14.3000	1	1
Gamma-aminobutyric acid receptor subunit alpha-6	Homo sapiens (human)	EC50	10.0225	4	4
Gamma-aminobutyric acid receptor subunit alpha-6	Mus musculus (house mouse)	EC50	14.3000	1	1
Gamma-aminobutyric acid receptor subunit beta-1	Homo sapiens (human)	EC50	24.8496	4	5
Gamma-aminobutyric acid receptor subunit beta-1	Mus musculus (house mouse)	EC50	14.3000	1	1
Gamma-aminobutyric acid receptor subunit beta-2	Homo sapiens (human)	EC50	5.3824	13	22
Gamma-aminobutyric acid receptor subunit beta-2	Rattus norvegicus (Norway rat)	EC50	2.3000	1	1
Gamma-aminobutyric acid receptor subunit beta-3	Homo sapiens (human)	EC50	26.7878	9	9
Gamma-aminobutyric acid receptor subunit beta-3	Mus musculus (house mouse)	EC50	14.3000	1	1
Gamma-aminobutyric acid receptor subunit delta	Mus musculus (house mouse)	EC50	14.3000	1	1
Gamma-aminobutyric acid receptor subunit gamma-1	Mus musculus (house mouse)	EC50	14.3000	1	1
Gamma-aminobutyric acid receptor subunit gamma-2	Homo sapiens (human)	EC50	13.6289	17	27
Gamma-aminobutyric acid receptor subunit gamma-2	Mus musculus (house mouse)	EC50	14.3000	1	1
Gamma-aminobutyric acid receptor subunit gamma-2	Rattus norvegicus (Norway rat)	EC50	2.3000	1	1
Gamma-aminobutyric acid receptor subunit gamma-3	Mus musculus (house mouse)	EC50	14.3000	1	1
Gamma-aminobutyric acid receptor subunit pi	Mus musculus (house mouse)	EC50	14.3000	1	1
Gamma-aminobutyric acid receptor subunit rho-1	Homo sapiens (human)	EC50	0.5275	6	9
Gamma-aminobutyric acid receptor subunit rho-1	Homo sapiens (human)	Kd	1.7000	1	1
Gamma-aminobutyric acid receptor subunit rho-2	Homo sapiens (human)	Kd	1.7000	1	1
Gamma-aminobutyric acid receptor subunit rho-3	Homo sapiens (human)	Kd	1.7000	1	1
Gamma-aminobutyric acid receptor subunit theta	Mus musculus (house mouse)	EC50	14.3000	1	1
Gamma-aminobutyric acid type B receptor subunit 1	Homo sapiens (human)	EC50	1.1150	2	2
Gamma-aminobutyric acid type B receptor subunit 2	Homo sapiens (human)	EC50	0.5300	1	1
Glutamate receptor 1	Homo sapiens (human)	EC50	792,445,056.0762	12	20
Glutamate receptor 1	Rattus norvegicus (Norway rat)	EC50	25.9385	7	8
Glutamate receptor 2	Homo sapiens (human)	EC50	722,116,393.1444	8	11
Glutamate receptor 2	Rattus norvegicus (Norway rat)	EC50	1,235,516,758.4248	5	6
Glutamate receptor 3	Homo sapiens (human)	EC50	2,264,128,594.8718	5	7
Glutamate receptor 3	Rattus norvegicus (Norway rat)	EC50	49.2397	6	7
Glutamate receptor 4	Homo sapiens (human)	EC50	9,952,675,009.4244	2	4
Glutamate receptor 4	Rattus norvegicus (Norway rat)	EC50	18.1741	5	6
Glutamate receptor ionotropic, kainate 1	Homo sapiens (human)	EC50	57.3333	3	3
Glutamate receptor ionotropic, kainate 1	Rattus norvegicus (Norway rat)	EC50	129.1633	2	3
Glutamate receptor ionotropic, kainate 2	Homo sapiens (human)	EC50	25.0000	2	2
Glutamate receptor ionotropic, kainate 2	Rattus norvegicus (Norway rat)	EC50	65.9615	2	3
Glutamate receptor ionotropic, NMDA 1	Rattus norvegicus (Norway rat)	EC50	0.8959	12	13
Glutamate receptor ionotropic, NMDA 2A	Rattus norvegicus (Norway rat)	EC50	1.1223	6	7
Glutamate receptor ionotropic, NMDA 2B	Rattus norvegicus (Norway rat)	EC50	0.4856	5	5
Glutamate receptor ionotropic, NMDA 2C	Rattus norvegicus (Norway rat)	EC50	0.3196	5	5
Glutamate receptor ionotropic, NMDA 2D	Rattus norvegicus (Norway rat)	EC50	0.1858	5	5
Glutamate receptor ionotropic, NMDA 3A	Rattus norvegicus (Norway rat)	EC50	0.1293	3	3
Glutamate receptor ionotropic, NMDA 3B	Rattus norvegicus (Norway rat)	EC50	0.1293	3	3
Glutamate transporter homolog	Pyrococcus horikoshii OT3	Kd	0.0010	1	1
Glycine receptor subunit alpha-1	Homo sapiens (human)	EC50	94.7496	1	2
Growth hormone secretagogue receptor type 1	Homo sapiens (human)	EC50	0.0660	1	1
guanine nucleotide-binding protein subunit alpha-15	Homo sapiens (human)	EC50	29.9020	1	1
Histamine H1 receptor	Cavia porcellus (domestic guinea pig)	EC50	0.1622	1	1
Histamine H1 receptor	Homo sapiens (human)	EC50	0.1511	8	8
Histamine H1 receptor	Rattus norvegicus (Norway rat)	EC50	4.4668	1	1
Histamine H1 receptor	Cavia porcellus (domestic guinea pig)	Kd	0.0008	1	3
Histamine H1 receptor	Homo sapiens (human)	Kd	0.0045	1	1
Histamine H2 receptor	Cavia porcellus (domestic guinea pig)	EC50	0.8074	5	5
Histamine H2 receptor	Homo sapiens (human)	EC50	1.8055	15	15
Histamine H2 receptor	Homo sapiens (human)	Kd	0.0122	1	1
Histamine H3 receptor	Homo sapiens (human)	EC50	0.0615	17	17
Histamine H3 receptor	Homo sapiens (human)	Kd	0.0030	1	1
Histamine H4 receptor	Homo sapiens (human)	EC50	0.1124	20	20
Histamine H4 receptor	Mus musculus (house mouse)	EC50	2.8596	5	5
Histamine H4 receptor	Rattus norvegicus (Norway rat)	EC50	14.1624	4	4
Histamine H4 receptor	Homo sapiens (human)	Kd	0.0105	2	2
Histamine H4 receptor	Mus musculus (house mouse)	Kd	0.0420	1	1
Histamine H4 receptor	Rattus norvegicus (Norway rat)	Kd	0.1340	1	1
Hsf1 protein	Mus musculus (house mouse)	EC50	195.0000	1	1
Integrin alpha-IIb	Homo sapiens (human)	EC50	7.4000	1	1
Integrin beta-3	Homo sapiens (human)	EC50	7.4000	1	1
Kappa-type opioid receptor	Homo sapiens (human)	EC50	0.0800	3	3
Mas-related G-protein coupled receptor member X2	Homo sapiens (human)	EC50	3.1000	2	2
Metabotropic glutamate receptor 1	Homo sapiens (human)	EC50	236.1900	4	5
Metabotropic glutamate receptor 1	Rattus norvegicus (Norway rat)	EC50	13.1512	10	12
Metabotropic glutamate receptor 2	Homo sapiens (human)	EC50	78.2859	12	14
Metabotropic glutamate receptor 2	Rattus norvegicus (Norway rat)	EC50	8.7450	8	10
Metabotropic glutamate receptor 3	Homo sapiens (human)	EC50	2.8572	5	5
Metabotropic glutamate receptor 3	Rattus norvegicus (Norway rat)	EC50	1.6294	3	4
Metabotropic glutamate receptor 4	Homo sapiens (human)	EC50	14.9333	3	3
Metabotropic glutamate receptor 4	Rattus norvegicus (Norway rat)	EC50	6.3776	8	10
Metabotropic glutamate receptor 5	Homo sapiens (human)	EC50	163.5500	4	4
Metabotropic glutamate receptor 5	Rattus norvegicus (Norway rat)	EC50	5.5081	9	12
Metabotropic glutamate receptor 6	Homo sapiens (human)	EC50	323.7250	3	4
Metabotropic glutamate receptor 6	Rattus norvegicus (Norway rat)	EC50	35.7000	5	5
Metabotropic glutamate receptor 7	Homo sapiens (human)	EC50	625.2950	4	4
Metabotropic glutamate receptor 7	Rattus norvegicus (Norway rat)	EC50	800.0000	2	3
Metabotropic glutamate receptor 8	Mus musculus (house mouse)	EC50	0.0220	1	1
Metabotropic glutamate receptor 8	Rattus norvegicus (Norway rat)	EC50	14.4933	3	3
Mu-type opioid receptor	Homo sapiens (human)	EC50	0.5895	5	6
Myelin basic protein	Mus musculus (house mouse)	Kd	0.0006	1	1
Neuromedin-K receptor	Homo sapiens (human)	EC50	0.7930	1	1
Neuromedin-K receptor	Rattus norvegicus (Norway rat)	EC50	7.5000	1	1
Neurotensin receptor type 1	Homo sapiens (human)	EC50	0.0632	5	5
Neurotensin receptor type 1	Mus musculus (house mouse)	EC50	0.0020	1	1
Neurotensin receptor type 1	Rattus norvegicus (Norway rat)	EC50	0.0000	1	1
Neurotensin receptor type 1	Homo sapiens (human)	Kd	0.0006	2	2
Neurotensin receptor type 2	Homo sapiens (human)	EC50	0.1100	1	1
Neurotensin receptor type 2	Rattus norvegicus (Norway rat)	EC50	0.1000	1	1
Olfactory receptor 51E2	Homo sapiens (human)	EC50	0.0580	1	1
Platelet glycoprotein VI	Homo sapiens (human)	Kd	0.0411	1	1
Proenkephalin-B	Homo sapiens (human)	Kd	0.0071	1	1
Prothrombin	Homo sapiens (human)	EC50	7.4000	1	1
Sterol O-acyltransferase 1	Mus musculus (house mouse)	EC50	14.3000	1	1
Substance-K receptor	Rattus norvegicus (Norway rat)	EC50	0.1670	1	1
Substance-P receptor	Homo sapiens (human)	EC50	0.0006	4	4
trace amine-associated receptor 1	Homo sapiens (human)	EC50	0.6756	4	6
Trace amine-associated receptor 1	Mus musculus (house mouse)	EC50	0.2800	1	1
Trace amine-associated receptor 1	Rattus norvegicus (Norway rat)	EC50	0.4663	2	3
Transient receptor potential cation channel subfamily A member 1	Rattus norvegicus (Norway rat)	EC50	3.6000	1	1
Transient receptor potential cation channel subfamily V member 1	Homo sapiens (human)	EC50	0.3072	5	5

Other Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
4-aminobutyrate aminotransferase, mitochondrial	Homo sapiens (human)	Km	1,950.0000	2	2
4-aminobutyrate aminotransferase, mitochondrial	Sus scrofa (pig)	Km	1,875.0000	4	4
5-hydroxytryptamine receptor 1A	Rattus norvegicus (Norway rat)	AC50	85.0000	1	1
5-hydroxytryptamine receptor 1D	Homo sapiens (human)	KA	127.5000	1	2
Adenosine receptor A1	Rattus norvegicus (Norway rat)	KA	125.0000	1	1
Adenosine receptor A2a	Rattus norvegicus (Norway rat)	KA	125.0000	1	2
Amine oxidase [flavin-containing] A	Homo sapiens (human)	Km	514.0000	1	1
Amine oxidase [flavin-containing] B	Homo sapiens (human)	Km	104.7000	1	1
aryl hydrocarbon receptor nuclear translocator	Homo sapiens (human)	AC50	23.0800	1	1
ATP-dependent translocase ABCB1	Homo sapiens (human)	AC50	85.0000	1	1
Breakpoint cluster region protein	Homo sapiens (human)	AC50	45.0000	1	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	Homo sapiens (human)	AC50	45.0000	1	1
Cannabinoid receptor 1	Homo sapiens (human)	Log Ki	0.0020	1	1
Cannabinoid receptor 2	Homo sapiens (human)	Log Ki	0.0026	1	1
Carbonic anhydrase	Candida albicans SC5314	KA	18.4000	1	1
Carbonic anhydrase	Methanosarcina thermophila	KA	63.0000	1	1
Carbonic anhydrase	Methanothermobacter thermautotrophicus str. Delta H	Ka	76.0000	1	1
Carbonic anhydrase	Saccharomyces cerevisiae S288C	Ka	20.4000	2	2
Carbonic anhydrase	Candida albicans SC5314	Km	8,200.0000	1	1
Carbonic anhydrase	Methanothermobacter thermautotrophicus str. Delta H	Km	1,700.0000	1	1
Carbonic anhydrase	Saccharomyces cerevisiae S288C	Km	9,500.0000	1	1
Carbonic anhydrase	Cryptococcus neoformans var. grubii	KA	33.2000	1	1
Carbonic anhydrase	Nakaseomyces glabratus CBS 138	Ka	27.4000	1	1
Carbonic anhydrase	Cryptococcus neoformans var. grubii	Km	9,000.0000	1	1
Carbonic anhydrase	Nakaseomyces glabratus CBS 138	Km	7,900.0000	1	1
Carbonic anhydrase 1	Homo sapiens (human)	KA	4.2117	21	24
Carbonic anhydrase 12	Homo sapiens (human)	KA	27.9250	4	4
Carbonic anhydrase 13	Homo sapiens (human)	KA	4.6000	1	1
Carbonic anhydrase 13	Mus musculus (house mouse)	KA	4.6000	2	2
Carbonic anhydrase 14	Homo sapiens (human)	KA	0.3880	5	5
Carbonic anhydrase 15	Mus musculus (house mouse)	KA	18.5000	1	1
Carbonic anhydrase 2	Homo sapiens (human)	KA	116.9808	23	26
Carbonic anhydrase 2	Homo sapiens (human)	Km	9,300.0000	1	1
Carbonic anhydrase 3	Homo sapiens (human)	KA	36.9250	4	4
Carbonic anhydrase 4	Bos taurus (cattle)	KA	44.8000	4	5
Carbonic anhydrase 4	Homo sapiens (human)	KA	24.7043	7	7
Carbonic anhydrase 5A, mitochondrial	Homo sapiens (human)	KA	0.6325	4	4
Carbonic anhydrase 5B, mitochondrial	Homo sapiens (human)	KA	3.5133	3	3
Carbonic anhydrase 6	Homo sapiens (human)	KA	14.2750	4	4
Carbonic anhydrase 7	Homo sapiens (human)	KA	31.4000	6	6
Carbonic anhydrase 9	Homo sapiens (human)	KA	35.0667	3	3
Carbonic anhydrase-like protein, putative	Trypanosoma cruzi strain CL Brener	KA	40.4767	1	3
Carboxylic ester hydrolase	Rattus norvegicus (Norway rat)	KA	32.7000	2	2
Choline O-acetyltransferase	Rattus norvegicus (Norway rat)	Km	290.0000	1	1
D(1A) dopamine receptor	Homo sapiens (human)	KL	219.0000	1	2
Delta-type opioid receptor	Mus musculus (house mouse)	Ke	0.0059	1	1
Dopamine beta-hydroxylase	Bos taurus (cattle)	Km	2,000.0000	1	1
Equilibrative nucleoside transporter 4	Homo sapiens (human)	K0.5	10,000.0000	2	2
Excitatory amino acid transporter 1	Homo sapiens (human)	Km	8.5500	2	2
Excitatory amino acid transporter 2	Homo sapiens (human)	Km	21.0000	2	2
Excitatory amino acid transporter 3	Homo sapiens (human)	Km	17.4500	2	2
Excitatory amino acid transporter 3	Rattus norvegicus (Norway rat)	Ks	5.1000	1	1
FAD-linked sulfhydryl oxidase ALR	Homo sapiens (human)	AC50	0.7780	1	1
Fatty-acid amide hydrolase 1	Mus musculus (house mouse)	Km	15.0000	1	1
Fatty-acid amide hydrolase 1	Rattus norvegicus (Norway rat)	Km	2.7800	1	1
Glutamate racemase	Enterococcus faecalis V583	Km	1,200.0000	1	1
Glutamate racemase	Helicobacter pylori 26695	Km	5,176.6667	3	3
Glutamate receptor ionotropic, NMDA 1	Rattus norvegicus (Norway rat)	KA	37.5000	1	1
Glutamate receptor ionotropic, NMDA 2A	Rattus norvegicus (Norway rat)	KA	37.5000	1	1
Glutamate receptor ionotropic, NMDA 2B	Rattus norvegicus (Norway rat)	KA	37.5000	1	1
Glutamate receptor ionotropic, NMDA 2C	Rattus norvegicus (Norway rat)	KA	37.5000	1	1
Glutamate receptor ionotropic, NMDA 2D	Rattus norvegicus (Norway rat)	KA	37.5000	1	1
Glutamate receptor ionotropic, NMDA 3A	Rattus norvegicus (Norway rat)	KA	37.5000	1	1
Glutamate receptor ionotropic, NMDA 3B	Rattus norvegicus (Norway rat)	KA	37.5000	1	1
Histamine H3 receptor	Rattus norvegicus (Norway rat)	Km	104.7000	1	1
Metabotropic glutamate receptor 1	Homo sapiens (human)	Activity	1.0000	1	1
Metabotropic glutamate receptor 2	Homo sapiens (human)	Activity	4.0000	1	1
Metabotropic glutamate receptor 3	Homo sapiens (human)	Activity	9.0000	1	1
Metabotropic glutamate receptor 4	Homo sapiens (human)	Activity	12.0000	1	1
Metabotropic glutamate receptor 5	Homo sapiens (human)	Activity	4.0000	1	1
Metabotropic glutamate receptor 6	Homo sapiens (human)	Activity	20.0000	1	1
Metabotropic glutamate receptor 7	Homo sapiens (human)	Activity	5,400.0000	1	1
Neurotensin receptor type 1	Homo sapiens (human)	Activity	0.0002	1	1
Neurotensin receptor type 2	Homo sapiens (human)	Activity	0.0011	1	1
Plasma kallikrein	Homo sapiens (human)	KA	3.5200	1	1
Polyphenol oxidase 2	Agaricus bisporus	Km	540.0000	1	1
POU domain, class 2, transcription factor 1	Homo sapiens (human)	Km	388.6000	1	1
Solute carrier family 22 member 1	Mus musculus (house mouse)	Km	42.0000	1	1
Solute carrier family 22 member 1	Rattus norvegicus (Norway rat)	Km	409.1000	6	6
Solute carrier family 22 member 1	Homo sapiens (human)	Activity	2,218.0000	1	3
Solute carrier family 22 member 2	Homo sapiens (human)	Km	450.5000	4	4
Solute carrier family 22 member 2	Rattus norvegicus (Norway rat)	Km	772.6000	4	5
Solute carrier family 22 member 3	Homo sapiens (human)	Km	180.0000	1	1
transforming acidic coiled-coil-containing protein 3	Homo sapiens (human)	AC50	23.0800	1	1
Transient receptor potential cation channel subfamily V member 1	Homo sapiens (human)	Activity	1.0000	1	1
Tyrosine-protein kinase ABL1	Homo sapiens (human)	AC50	45.0000	1	1