| Excerpt | Reference |
|---|
| "Maternal alcohol abuse is difficult to assess by laboratory tests." | ( Halmesmäki, E; Roine, R; Salaspuro, M, 1992) |
| "Alcohol dependence is a major public health problem." | ( Linnoila, M; Wozniak, KM, 1992) |
| "We conclude that alcohol abuse is an important, though often undetected, seizure etiology carrying a poor prognosis." | ( Hillbom, ME; Pieninkeroinen, IP; Telakivi, TM, 1992) |
| "An animal model of alcohol dependence is being produced by selecting mice for differences in severity of ethanol withdrawal seizures." | ( Berta, J; Wilson, JR, 1992) |
| "Comorbid alcohol use disorders are common in schizophrenia." | ( Beaudett, MS; Drake, RE; Hurlbut, SC; Noordsy, DL; Osher, FC; Paskus, TS; Teague, GB, 1991) |
| "Alcoholism and alcohol abuse are serious health problems." | ( Gianoulakis, C, 1989) |
| "Alcohol abuse is consequently a major health problem affecting 1-1." | ( Palmer, TN, 1989) |
| "Alcohol abuse is a commonly associated disorder in femoral neck fractures in men, but little attention is given to such an association in women." | ( Menashe, L; Schnitzler, CM; Sutton, CG; Sweet, MB, 1988) |
| "Alcohol dependence is characterized by reduced cAMP content in the majority of brain structures studied, sharply decreased met-enkephalin levels in limbic cortex and hypothalamus, and diminished cAMP and cGMP content in hypothalamus." | ( Balakleevskiĭ, AI; Maslova, IV; Petrenko, SV; Surikov, PM, 1986) |
| "Alcohol abuse is often difficult to diagnose in the early stages in the absence of physical manifestations and where patients are unaware of their alcohol dependence." | ( Barr, GD; Mistilis, SP, 1981) |
| "Alcohol abuse is the single most important aggravating factor in trauma and the severity of injuries sustained therefrom." | ( Maull, KI, 1982) |
| "Chronic alcohol abuse is responsible for several organic brain disorders." | ( Den Bulk, A; Kornreich, C; Le Bon, O; Mampunza, S; Martin, P; Paternot, J; Pelc, I; Verbanck, P; Verhas, M, 1995) |
| "Preinjury habitual alcohol abuse is frequent in head-injured patients." | ( Dikmen, SS; Donovan, DM; Machamer, JE; Temkin, NR; Winn, HR, 1995) |
| "Alcohol dependence is considered to be divisible into two types (although the divisions between these are indistinct)." | ( Little, H; Littleton, J, 1994) |
| "Alcohol abuse is associated with an increased risk of readmission for new trauma." | ( Gurney, JG; Jurkovich, GJ; Koepsell, TD; Rivara, FP; Soderberg, R, 1993) |
| "The consequences of alcohol abuse are both physical and psychic, thus therapeutic approaches must take into account these two points." | ( Costa, R; Marino, A, 1993) |
| "Alcohol abuse is known to cause disturbances to iron homeostasis in man and is associated with elevated serum ferritin levels." | ( Loney, LA; Potter, BJ; Zhang, H, 1993) |
| "Chronic alcohol abuse is frequent in patients admitted to the intensive care unit with acute drug overdose." | ( Köppel, C; Müller, C; Wrobel, N, 1996) |
| "Since alcohol addiction is frequently denied, determination of carbohydrate deficient transferrin may be useful for its early diagnosis but the sensitivity of this parameter requires further evaluation." | ( Köppel, C; Müller, C; Wrobel, N, 1996) |
| "Alcohol abuse is one of the most serious problems in public health and the Wernicke-Korsakoff syndrome is one of the gravest consequences of alcoholism." | ( Fernandes, JG; Rodnight, R; Zubaran, C, 1997) |
| "Patients with alcohol addiction are analyzed after one year from the beginning of therapy." | ( Becagli, A; Cecchetti, E; Cimarosti, P; Costella, V; Santonastaso, M; Tagliamento, A; Zanatta, N, 1997) |
| "Alcohol abuse is often accompanied by cognitive impairment." | ( Korbo, L, 1999) |
| "Alcohol abuse is commonly associated with reduced bone mass and osteoporosis as a consequence of both systemic and direct cellular effects." | ( Girasole, G; Giuliani, N; Passeri, G; Pedrazzoni, M; Vescovi, PP, 1999) |
| "Alcohol abuse is one of the most common causes of seizures in adults." | ( D'Onofrio, G; Fish, SS; Freedland, ES; Rathlev, NK; Ulrich, AS, 1999) |
| "Chronic alcohol abuse is associated with energy wasting and inhibition of adipose tissue accumulation." | ( Harris, MM; Levine, JA; Morgan, MY, 2000) |
| "Alcohol abuse is roughly twice as common as alcohol dependence." | ( Gillet, C; Loisequx-Meunier, MN; Maradeix, B; Planche, F; Reynaud, M; Schellenberg, F; Schwan, R, 2000) |
| "Long-term alcohol abuse is known to target specific areas of the brain such as the superior frontal cortex (SFC), resulting in neuronal cell loss." | ( Buckley, ST; Dodd, PR; Eckert, AL, 2000) |
| "Alcohol abuse is an essential factor promoting an excessive reduction of bone mass during the normal male aging." | ( Jankowska, EA; Medraś, M, 2000) |
| "Ethanol abuse is also associated with abnormalities in carbohydrate (as well as lipid) metabolism in skeletal muscle." | ( Dhillon, AS; Mantle, D; Paice, A; Palmer, TN; Peters, TJ; Preedy, VR, 2001) |
| "Paternal history of alcohol dependence is associated with greater discount rates among women." | ( Kirby, KN; Kranzler, HR; Petry, NM, 2002) |
| "Chronic alcohol abuse is associated with both an altered response to infection and deranged iron homeostasis." | ( Potter, BJ; Wang, F, 2002) |
| "Alcohol abuse is a common cause of hyperhomocysteinemia that often fluctuates and is sometimes severe." | ( Carmel, R; James, SJ, 2002) |
| "Drug and alcohol abuse is one of the United States' most expensive and damaging health risk." | ( Steiner, GG, 2001) |
| "Alcohol dependence is a prevalent psychiatric disorder affecting approximately 12% of the adult population at some point in their lifetime." | ( Baker, RP; Boislard, J; Campbell, W; Cunningham, GM; Jovey, RD; Landry, M; Lemire, E; McKay, C; Mercier, C; Pépin, JM; Perreault, J; Romach, MK; Ryan, D; Sellers, EM; Somer, GR, 2002) |
| "Chronic alcohol abuse is associated with an increased incidence of ARDS and the severity of multiple organ dysfunction." | ( Burnham, EL; Moss, M, 2003) |
| "Alcohol dependence is one of the most pervasive diseases of the Western world." | ( Heinz, A; Mann, K; Wilwer, M, 2003) |
| "Alcohol abuse is the third leading preventable cause of death in the United States." | ( , 2004) |
| "Alcohol dependence is characterized by the development of tolerance, withdrawal symptoms, and craving for alcohol." | ( Gallinat, J; Goldman, D; Heinz, A; Puls, I; Schumann, G, 2004) |
| "Although alcohol abuse is known to cause a wide array of adverse effects on blood cell formation, the molecular mechanisms by which alcohol exerts its toxic actions have remained poorly defined." | ( Niemelä, O; Parkkila, S, 2004) |
| "Alcohol abuse is the major cause of morbidity and mortality in western countries." | ( Guiducci, MS; Mancinelli, R, 2004) |
| "Alcohol abuse is often associated with acute pancreatitis." | ( Clemens, DL; Jerrells, TR, 2004) |
| "Alcohol abuse is a very common problem all over the world." | ( Boşgelmez, II; Doğan, YB; Güvendik, G; Idiz, N; Ilhan, I; Söylemezoğlu, T, 2004) |
| "Alcohol dependence is associated with an increased incidence of hypertension and cardiac arrhythmias, but the triggering mechanisms are not known." | ( Irwin, MR; Ziegler, M, 2005) |
| "Alcohol dependence is a common disorder associated with significant morbidity and mortality." | ( Ehrich, EW; Garbutt, JC; Gastfriend, DR; Kranzler, HR; Loewy, JW; O'Malley, SS; Pettinati, HM; Silverman, BL, 2005) |
| "Alcohol abuse is common in patients with squamous cell cancer of the head and neck." | ( Gourin, CG; Neyman, KM; Terris, DJ, 2005) |
| "Comorbid alcohol dependence is common in patients with schizophrenia and is associated with a variety of serious adverse consequences." | ( Beyazyürek, M; Kalyoncu, A; Mirsal, H; Pektas, O; Tan, D; Unsalan, N, 2005) |
| "Severe alcohol dependence is associated with markedly raised plasma homocysteine levels in both females and males." | ( Beasley, R; Narasimhan, S; Robinson, G; Weatherall, M, 2005) |
| "Chronic alcohol abuse is a ubiquitous health and societal problem, with a growing prevalence in the older population." | ( Adalsteinsson, E; Pfefferbaum, A; Sullivan, EV, 2006) |
| "Alcohol abuse is associated with menstrual irregularities related to the inhibition of progesterone secretion involved in regulation of the menstrual cycle." | ( Cerny, I; Cibula, D; Havlikova, H; Hill, M; Kancheva, L; Kancheva, R; Meloun, M; Popov, P; Pouzar, V; Starka, L; Vrbikova, J, 2005) |
| "The duration of alcohol dependence is significantly correlated with the levels of MDA." | ( Chen, CC; Huang, MC; Kuo, TL; Peng, FC; Tang, SH; Yin, SJ, 2005) |
| "Alcohol dependence is a progressive chronic disease that is associated with changes in neuroanatomy, neurophysiology, neural gene expression, psychology, and behavior." | ( Buckley, T; Crews, FT; Dodd, PR; Ende, G; Foley, N; Harper, C; He, J; Innes, D; Loh, el-W; Pfefferbaum, A; Sullivan, EV; Zou, J, 2005) |
| "Alcohol dependence is characterized by frequent, compulsive and uncontrolled consumption of alcohol associated with behavior of maladaption and destruction." | ( Lesch, KP, 2005) |
| "Alcohol abuse is associated with increases in both the incidence of fractures and complications in fracture healing." | ( Chakkalakal, DA; Donohue, TM; Fritz, ED; Garvin, KL; McGuire, MH; McVicker, DL; Mollner, TJ; Novak, JR, 2005) |
| "Alcohol dependence is a common, complex disorder, which affects millions of people worldwide and causes considerable burden in terms of interpersonal and societal costs." | ( Bierut, LJ; Dick, DM, 2006) |
| "Alcohol dependence is a chronic disorder that results from a variety of genetic, psychosocial, and environmental factors." | ( Jung, YC; Namkoong, K, 2006) |
| "Alcohol dependence is characterized by excessive alcohol consumption, loss of control over intake, and the presence of a withdrawal syndrome, which includes both motivational and physical symptoms." | ( Funk, CK; Koob, GF; Lee, MJ; Rice, KC; Zorrilla, EP, 2007) |
| "Once alcohol dependence is established, alcohol-associated cues may induce dopamine release in the reward system, which is accompanied by alcohol craving and may lead to relapse." | ( Braus, DF; Flor, H; Georgi, A; Heinz, A; Hermann, D; Klein, S; Mann, K; Nikitopoulos, J; Smolka, MN; Wrase, J, 2006) |
| "Alcohol dependence is associated with time-dependent changes in brain GABA(A) receptor density and subunit gene expression levels that contribute to a withdrawal-related deficit in GABA(A) receptor function." | ( Gelernter, J; Harris, RA; Kaufman, J; Krystal, JH; Lappalainen, J; Mason, G; Petrakis, IL; Staley, J, 2006) |
| "Alcohol dependence is one of the leading causes of morbidity worldwide, yet only a minority of those afflicted engages in treatment." | ( Berrettini, WH; O'Brien, CP; Oslin, DW, 2006) |
| "Alcohol abuse is even more difficult to assess: the border between acceptable convivial and excessive consumption is not clear-cut, except during pregnancy where there should be no alcohol consumption." | ( Commenges-Ducos, M, 2006) |
| "Alcoholism, or alcohol dependence, is a complex disorder with withdrawal symptoms that are often problematic for those trying to recover from their dependence." | ( Devaud, LL; Risinger, FO; Selvage, D, 2006) |
| "Alcohol abuse is associated with increased fibronectin mRNA expression in alveolar macrophages and increased fibronectin-inducing activity in the ELF." | ( Burnham, EL; Moss, M; Ritzenthaler, JD; Roman, J, 2007) |
| "Alcohol dependence is a common, debilitating disorder." | ( Bankes, L; Brown, TM; Guzik, P, 2007) |
| "Alcohol abuse is a major cause of liver cirrhosis as well as chronic liver disease." | ( Bagos, P; Boufidou, F; Chatzipanagiotou, S; Liappas, IA; Nicolaou, C; Papageorgiou, C; Piperi, C; Soldatos, CR; Tzavellas, EO, 2007) |
| "Alcohol dependence is characterized by excessive consumption, loss of control over intake and the presence of a withdrawal syndrome, including both motivational and physical symptoms." | ( Funk, CK; Koob, GF, 2007) |
| "Alcohol abuse is a risk factor for bone fractures." | ( Hardin, K; Ho, E; Hunter, JC; Iwaniec, UT; Menagh, PJ; Pfaff, JE; Trevisiol, CH; Turner, RT, 2007) |
| "Alcohol dependence is a common disorder with a heterogenous etiology." | ( Köhnke, MD, 2008) |
| "Alcohol abuse is the major cause of chronic inflammation of the pancreas (i." | ( Apte, MV; Pirola, RC; Vonlaufen, A; Wilson, JS, 2007) |
| "Alcohol dependence is a chronic disorder in which withdrawal symptoms often persist after detoxification." | ( Weiss, F; Zhao, Y; Zorrilla, EP, 2007) |
| "Alcohol dependence is a major public health challenge in need of new treatments." | ( Brandt, JE; Gehlert, DR; George, DT; Geyer, C; Gilman, J; Heilig, M; Herion, D; Hersh, J; Hommer, D; Hunt, SP; Kielbasa, W; Peng, X; Rawlings, R; Tauscher, JT; Thorsell, A, 2008) |
| "A review about alcohol dependence is warranted, not only as prevalence of this disease is high, but also because of recent significant improvement in caring for these patients." | ( Blanc, F; Perney, P; Rigole, H, 2008) |
| "Alcohol dependence is extremely common in patients with bipolar disorder, and it is associated with unfavorable outcomes, including treatment nonadherence, violence, and cognitive impairment." | ( Brown, ES; Carmody, TJ; Garza, M, 2008) |
| "In conclusion alcohol abuse is associated with an accelerated progression of liver injury, leading to an earlier development of cirrhosis, higher incidence of hepatocellular carcinoma, and higher mortality." | ( Andreone, P; Bernardi, M; Conti, F; Gitto, S; Micco, L, 2009) |
| "Alcohol addiction is typically associated with intense alcohol craving triggered by internal or environmental cues linked with past alcohol use." | ( Beblo, T; Driessen, M; Kunz, S; Woermann, F, 2008) |
| "Alcohol dependence is frequently associated with anxiety disorders." | ( Levin, FR; Mariani, JJ, 2008) |
| "Alcohol dependence is a chronic disease whose treatment begins with detoxification, followed by rehabilitation." | ( Ballester, AH; Climent Diaz, B; Garcia Escriva, D; Gonzalez Valles, V; Guijarro Agustin, MJ; Herrera de Pablo, P; Perez-Silvestre, J, 2008) |
| "As prolonged alcohol abuse is known to impair response inhibition, alcohol abusers may benefit from interventions that increase response inhibition, thereby restoring inhibitory control over automatic impulses." | ( Houben, K; Wiers, RW, 2009) |
| "Alcohol abuse is a global problem due to the financial burden on society and the healthcare system." | ( Dolganiuc, A; Szabo, G, 2009) |
| "Although chronic alcohol abuse is known to cause osteopenia, little is known about the effects of binge drinking on bone metabolism." | ( Brownson, K; Callaci, JJ; Himes, R; Lauing, K; Wezeman, FH, 2009) |
| "Alcohol dependence is often associated with impulsivity, which may be correlated with dysfunction of the brain reward system." | ( Beck, A; Hägele, C; Hein, J; Heinz, A; Kahnt, T; Kienast, T; Knutson, B; Schlagenhauf, F; Schmack, K; Wrase, J; Wüstenberg, T, 2009) |
| "Alcohol dependence is a widespread psychiatric disorder." | ( Rösner, S; Soyka, M, 2008) |
| "Alcohol dependence is extremely common in patients with bipolar disorder and is associated with unfavorable outcomes including treatment nonadherence, violence, increased hospitalization, and decreased quality of life." | ( Adinoff, B; Brown, ES; Caetano, R; Carmody, TJ; John Rush, A; Schmitz, JM; Swann, AC, 2009) |
| "Alcohol abuse is the second most common mental disorder worldwide." | ( Flatscher-Bader, T; Wilce, PA, 2009) |
| "Alcohol addiction is a common affliction with a strong genetic component [1]." | ( Devineni, AV; Heberlein, U, 2009) |
| "Alcohol use disorder is often associated with suicidal behavior." | ( Arango, V; Cooper, TB; Hungund, BL; Kassir, SA; Mann, JJ; Vinod, KY, 2010) |
| "Alcohol addiction is a complex brain disease caused by alterations in crucial neurotransmitter systems, including gamma-aminobutyric acid (GABA) and glutamate." | ( Bergmann, J; Caleri, F; Golaszewski, S; Kronbichler, M; Ladurner, G; Lochner, P; Nardone, R; Tezzon, F, 2010) |
| "Alcohol dependence is a major disease burden of adults in modern society worldwide." | ( He, SM; Li, Y; Liang, J; Wang, LL; Yang, AK; Zhou, SF; Zhou, ZW, 2010) |
| "Alcohol dependence is a major health problem worldwide." | ( De Sousa, A, 2010) |
| "Alcohol dependence is a costly and socially devastating illness." | ( Anton, RF; Vergne, DE, 2010) |
| "Abstract Alcohol abuse is a major cause of abnormal liver function throughout the world." | ( Alatalo, P; Niemelä, O, 2010) |
| "Alcohol abuse is a major public health problem and one of the leading causes of preventable death." | ( Ejilemele, AA; Orluwene, CG, 2010) |
| "Alcohol addiction is associated with alterations of central nervous dopaminergic and serotonergic functions." | ( Bandelow, B; Engel, K; Falkai, P; Havemann-Reinecke, U; Herchenhein, T; Kirchhainer, J; Malchow, B; Wedekind, D, 2010) |
| "Alcohol abuse is a serious medical and social problem." | ( Guo, R; Ren, J, 2010) |
| "The development of alcohol dependence is posited to involve numerous changes in brain chemistry (i." | ( Bhave, SV; Clapp, P; Hoffman, PL, 2008) |
| "Alcohol dependence is frequently associated with aggressive and suicidal behaviour." | ( Borovecki, F; Muck-Seler, D; Nedic, G; Nikolac, M; Pivac, N; Sviglin, KN, 2011) |
| "Alcohol dependence is correlated with a wide spectrum of medical, psychological, behavioral, and social problems." | ( Manzo-Avalos, S; Saavedra-Molina, A, 2010) |
| "Alcohol abuse is a leading cause of pancreatitis, accounting for 30% of acute cases and 70-90% of chronic cases, yet the mechanisms leading to alcohol-associated pancreatic injury are unclear." | ( Ahmad, A; Husain, SZ; Luo, Y; Mahmood, SM; Muili, K; Orabi, AI; Reed, A; Shah, AU, 2011) |
| "Alcohol dependence is the third leading cause of preventable death in the USA." | ( Bond, C; Breslin, FJ; Johnson, BA; Lynch, WJ, 2011) |
| "Alcohol abuse is a major global health problem, but there is still much uncertainty about the mechanisms of action." | ( Ebisui, E; Ferdek, P; Gerasimenko, JV; Gerasimenko, OV; Lur, G; Mikoshiba, K; Petersen, OH; Sherwood, MW; Tepikin, AV, 2011) |
| "Alcohol dependence is associated with high rates of recidivism." | ( Crane, NA; Goodell, V; Higley, AE; Mason, BJ; Quello, SB; Spadoni, AD, 2011) |
| "Khat use and ethanol abuse are increasingly becoming global health concerns especially among many disadvantaged social groups." | ( Alele, PE; Rujumba, JB, 2011) |
| "Tobacco and alcohol dependence are characterized by continued use despite deleterious health, social and occupational consequences, implying that addicted individuals pay a high price for their use." | ( De Vries, TJ; Diergaarde, L; Pattij, T; Schoffelmeer, AN; van Mourik, Y, 2012) |
| "Chronic smoking in alcohol dependence is associated with abnormalities in brain morphology and metabolite levels in large lobar regions (e." | ( Durazzo, TC; Gazdzinski, S; Meyerhoff, DJ; Mon, A, 2013) |
| "Alcohol dependence is associated with neurocognitive deficits related to neuropathological changes in structure, metabolism, and function of the brain." | ( Katwal, SB; Martin, PR; Nickel, MK; Parks, MH; Rogers, BP, 2012) |
| "Alcohol dependence is associated with a wide array of physical and psychiatric complications and is a major cause of morbidity and mortality worldwide." | ( Currie, J; Jones, DM; Pastor, A, 2012) |
| "Alcohol addiction is a chronically relapsing disorder characterized by compulsive alcohol seeking and use." | ( Martin-Fardon, R; Weiss, F, 2013) |
| "Chronic alcohol abuse is a comorbid variable of acute respiratory distress syndrome." | ( Brown, LA; Harris, FL; Hart, CM; Yeligar, SM, 2012) |
| "Alcohol abuse is associated with increased lung infections." | ( Raju, SV; Wang, G, 2012) |
| "Alcohol dependence is a common neuropsychiatric disorder with high heritability." | ( Buitelaar, JK; Cools, A; de Jong, CA; Ellenbroek, B; Franke, B; Schellekens, AF; Verkes, RJ, 2012) |
| "Alcohol abuse is a risk factor for both liver cirrhosis and chronic pancreatitis." | ( Balakrishnan, V; Rajesh, G; Sundaram, KR; Varghese, J; Veena, AB, 2012) |
| "Alcohol dependence is a complex psychiatric disorder demanding development of novel pharmacotherapies." | ( Lawrence, AJ; Liang, JH; Liu, Q; Qin, WJ; Wang, WP; Wen, RT; Zhang, HT; Zhang, M, 2012) |
| "Alcohol dependence is a disorder with an impulsive and compulsive "drive" toward alcohol consumption and an inability to inhibit alcohol consumption." | ( Camchong, J; Fein, G; Stenger, A, 2013) |
| "Alcohol dependence is associated with increased mortality, but it is not clear whether certain laboratory abnormalities on admission predict premature death in discharged alcoholic patients." | ( Ahn, MH; Choi, SH; Hong, JP; Park, S, 2013) |
| "Alcohol dependence is a chronically relapsing disorder characterized by compulsive drug seeking and drug taking, loss of control in limiting intake, and the emergence of a withdrawal syndrome in the absence of the drug." | ( Gilpin, NW; Roberto, M; Siggins, GR, 2012) |
| "Alcohol dependence is associated with increased corticotropin releasing factor (CRF) influence on CeA GABA release and CRF type 1 receptor (CRF(1)) antagonists prevent the excessive alcohol consumption associated with dependence." | ( Ciccocioppo, R; Heilig, M; Herman, MA; Kallupi, M; Koob, GF; Luu, G; Oleata, CS; Roberto, M, 2013) |
| "Alcohol use disorder is a compulsive behavior driven by motivational systems and by a poor control of consummatory behavior." | ( Aguilar-Roblero, R; Caynas Rojas, S; Gómez Armas, D; Méndez-Díaz, M; Prospéro-García, O; Ruiz-Contreras, AE, 2013) |
| "Alcohol use disorders are chronic disabling conditions for which existing pharmacotherapies have only modest efficacy." | ( de Wit, H; Heilig, M; Shaham, Y; Zorrilla, EP, 2013) |
| "Alcohol abuse is also associated with a higher incidence of sepsis or pneumonia resulting in a higher rate of admittance to intensive care, longer inpatient stays, higher healthcare costs, and a 2-4 times greater mortality rate." | ( Brown, LA; Liang, Y; Yeligar, SM, 2012) |
| "Chronic alcohol abuse is associated with deficits in cognitive control functions." | ( Dom, G; Goudriaan, AE; Joos, L; Krüse, AM; Schmaal, L; van den Brink, W; Veltman, DJ, 2013) |
| "A key deficit in alcohol dependence is disrupted prefrontal function leading to excessive alcohol seeking, but the molecular events underlying the emergence of addictive responses remain unknown." | ( Bauder-Wenz, C; Drescher, KU; Hansson, AC; Harper, C; Heilig, M; Meinhardt, MW; Perreau-Lenz, S; Sommer, WH; Spanagel, R; Stählin, O, 2013) |
| "Alcohol addiction is a complex, unique human disease." | ( Atkinson, NS; Robinson, BG, 2013) |
| "Alcohol dependence is associated with a number of adverse individual and societal consequences and high rates of morbidity and mortality." | ( Montoya, ID, 2013) |
| "Alcohol abuse is a common problem in society; however, the technical capabilities of evaluating individual alcohol consumption using objective biomarkers are rather limited at present." | ( Büchner, M; Gapert, R; Hartwig, S; Hastedt, M; Heinz, A; Herre, S; Kienast, T; Krumbiegel, F; Rothe, M; Tsokos, M, 2013) |
| "Long term alcohol abuse is associated with deficiencies in essential nutrients and minerals that can cause a variety of medical consequences including accumulation of toxic metals." | ( Attilia, ML; Barlocci, E; Ceccanti, M; Ciprotti, M; Draisci, R; Fidente, RM; Fiore, M; Mancinelli, R; Senofonte, O; Vitali, M, 2013) |
| "Chronic alcohol abuse is associated with increased risk of osteoporosis while light-to-moderate alcohol intake correlates with reduced osteoporosis risk." | ( Iwaniec, UT; Turner, RT, 2013) |
| "Alcohol dependence is a chronic relapsing disorder characterized by neuroadaptations that may result in the emergence of negative affective states and stress responses upon discontinuation of alcohol use." | ( Higley, AE; Koob, GF; Mason, BJ, 2012) |
| "Alcohol dependence is associated with impaired control over emotionally motivated actions, possibly associated with abnormalities in the frontoparietal executive control network and midbrain nodes of the reward network associated with automatic attention." | ( Hawkes, WC; Jung, YC; Müller-Oehring, EM; Pfefferbaum, A; Schulte, T; Sullivan, EV, 2013) |
| "Alcohol dependence is a chronic, progressive neurobiological brain disorder." | ( Bhaskar, LV; Kumar, KP; Pardhasaradhi, G; Rao, VR; Singh, L; Thangaraj, K, 2013) |
| "Alcohol addiction is one of the most common and devastating diseases in the world." | ( Berrettini, W, 2013) |
| "Alcohol dependence is a complex disease caused by a confluence of environmental and genetic factors." | ( Hao, W; Li, W; Liao, Y; Miao, Q; Tang, J; Zhang, R; Zhao, R, 2013) |
| "Alcohol addiction is a major social and health concern." | ( Chen, X; Cheng, Y; Guan, Y; Kuzhikandathil, EV; Li, J; Li, W; Liu, X; Liu, Y; Qin, S; Wang, S; Xiong, M; Ye, JH; Zhang, C, 2013) |
| "Alcohol use disorders are well recognized to be common, debilitating, and the risk of developing them is influenced by family history (FH)." | ( Arias, AJ; Kerfoot, K; Koretski, J; Limoncelli, D; Newcomb, J; Petrakis, IL; Pittman, B; Ralevski, E, 2013) |
| "Alcohol dependence is a heterogeneous disorder where several signalling systems play important roles." | ( Engel, JA; Fredriksson, I; Jerlhag, E; Steensland, P; Suchankova, P, 2013) |
| "Alcohol dependence is associated with severe nutritional and vitamin deficiency." | ( Butler, MG; Campbell, J; He, J; Manzardo, AM; Penick, EC; Poje, A, 2013) |
| "Alcohol use disorder is one of the leading causes of disability worldwide." | ( Ingram, E; Lantinga, LJ; Lynch, KG; Maisto, SA; McKay, JR; Oslin, DW; Possemato, K; Wierzbicki, M, 2014) |
| "Alcohol dependence is a complex disorder affecting all social and ethnic groups." | ( Awofala, AA, 2013) |
| "Alcohol dependence is a severe, chronic illness." | ( , 2013) |
| "Alcoholism (alcohol dependence) is characterized by a compulsion to seek and ingest alcohol (ethanol), loss of control over intake, and the emergence of a negative emotional state during withdrawal." | ( Roberts, AJ; Vendruscolo, LF, 2014) |
| "Alcohol dependence is a major public health problem that is characterised by recidivism and a host of medical and psychosocial complications." | ( Maremmani, I; Pacini, M; Pani, PP; Trogu, E, 2014) |
| "Alcohol addiction is a major psychiatric disease, and yet, the underlying molecular adaptations in the brain remain unclear." | ( Biermann, T; Desrivières, S; Easton, AC; Fernandes, C; Fernández-Medarde, A; Kornhuber, J; Lourdusamy, A; Müller, CP; Rotter, A; Santos, E; Schumann, G, 2014) |
| "Alcohol addiction is a chronic relapsing disorder that presents a substantial public health problem, and is frequently co-morbid with posttraumatic stress disorder (PTSD)." | ( George, DT; Heilig, M; Hommer, DW; Kwako, LE; Ramchandani, VA; Schwandt, ML; Sells, JR; Sinha, R, 2015) |
| "Alcohol dependence is a risk factor for the refeeding syndrome." | ( Gilmour, M; Manning, S; Robinson, GM; Weatherall, M, 2014) |
| "Alcohol dependence is a complex condition with clear genetic factors." | ( Harris, RA; Mayfield, J; Messing, RO; Trudell, JR, 2014) |
| "Alcohol dependence is common in bipolar disorder (BPD) and associated with treatment nonadherence, violence, and hospitalization." | ( Adinoff, B; Bret, ME; Brown, ES; Caetano, R; Carmody, TJ; Davila, D; Holmes, T; Lo, A; Nakamura, A; Rush, AJ; Sunderajan, P; Swann, AC, 2014) |
| "Individuals with alcohol dependence are known to make disadvantageous decisions, possibly caused by alterations in either reward or punishment sensitivity, which lead to persistent alcohol use despite its adverse consequences." | ( Clark, L; Goudriaan, AE; van den Brink, W; van Holst, RJ; Veltman, DJ, 2014) |
| "Alcohol dependence is a chronic, severe and sometimes fatal disease." | ( , 2014) |
| "Alcohol addiction is a widespread societal problem, for which there are few treatments." | ( Bettinger, JC; Davies, AG; Mathies, LD; Raabe, RC, 2014) |
| "Alcohol addiction is a common problem in daily life as well as in medicine." | ( Grehl, O, 2014) |
| "The development of alcohol dependence is a complex and dynamic process that ultimately reflects a maladaptive neurophysiologic state." | ( Becker, HC; Mulholland, PJ, 2014) |
| "Alcohol dependence is one of the leading contributors to the burden of disease in the world." | ( Friedel, E; Hägele, C; Kiefer, F; Kienast, T, 2014) |
| "Alcohol use disorder is also very common: 5." | ( Bendimerad, P; Blecha, L, 2014) |
| "Alcohol abuse is a widespread and serious problem." | ( Austin, MK; Bettinger, JC; Blackwell, GG; Davies, AG; Edwards, AC; Mathies, LD; Riley, BP, 2015) |
| "Alcohol use disorder is one of the leading causes of disability worldwide." | ( Berrettini, W; Gordon, AJ; Leong, SH; Lynch, KG; O'Brien, CP; Oslin, DW; Rukstalis, M, 2015) |
| "Alcohol use disorders are common, but only a small minority of patients receive adequate treatment." | ( Lieb, M; Soyka, M, 2015) |
| "Alcohol use disorder is a chronic relapsing brain disease characterized by the loss of ability to control alcohol (ethanol) intake despite knowledge of detrimental health or personal consequences." | ( Ball, LE; Gass, JT; Griffin, WC; McGuier, NS; Mulholland, PJ; Uys, JD, 2016) |
| "Alcoholism, or alcohol use disorder, is a major public health concern that is a considerable risk factor for morbidity and disability; therefore, effective treatments are urgently needed." | ( Belanoff, JK; Edwards, S; Estey, D; George, O; Goodell, V; Hunt, HJ; Koob, GF; Logrip, ML; Macshane, LG; Mason, BJ; McGinn, MA; Sanna, PP; Schlosburg, JE; Vendruscolo, LF; Zamora-Martinez, ER, 2015) |
| "Harmful effects of alcohol abuse are well documented for drinkers, and adverse effects are also reported for the physical and emotional well-being of family members, with evidence often originating from either drinkers or their families in clinic-based settings." | ( Dhillon, PK; Ebrahim, S; Gupta, A; Gupta, R; Jha, DK; Priya, B; Sharma, M; Williams, J, 2015) |
| "Alcohol addiction is considered maladaptive learning and memory processes." | ( Ben Hamida, S; Cheng, Y; Gil, H; Ma, T; Roltsch Hellard, E; Ron, D; Wang, J; Wang, X, 2015) |
| "Alcohol abuse is a major risk factor for somatic and neuropsychiatric diseases." | ( Gulbins, E; Hönig, S; Kleuser, B; Kornhuber, J; Liebisch, G; Lüth, A; Reichel, M; Schmitz, G, 2015) |
| "Alcohol dependence is characterized by a reduction in reward threshold, development of a negative affective state, and significant cognitive impairments." | ( Burnett, EJ; Chandler, LJ; Trantham-Davidson, H, 2016) |
| "Alcohol dependence is known to be associated with steep discounting of delayed rewards, but its relation to the discounting of delayed losses and probabilistic rewards is unclear." | ( Green, L; Grucza, RA; Myerson, J; van den Berk-Clark, C, 2015) |
| "Alcohol dependence is a devastating illness affecting a large population, and new pharmacological treatments with good efficacy are greatly needed." | ( Asanovska, G; de Bejczy, A; Franck, J; Guterstam, J; Hammarberg, A; Isaksson, A; Löf, E; Söderpalm, B; Walther, L, 2015) |
| "Alcohol use disorders are associated with deficits in adaptive behavior." | ( Barker, JM; Chandler, LJ; Lench, DH, 2016) |
| "Alcohol dependence is thought to result from an overactive neural motivation system and a deficient cognitive control system, and rebalancing these systems may mitigate excessive alcohol use." | ( Goudriaan, AE; Jansen, JM; van den Brink, W; van Wingen, G, 2015) |
| "Alcohol dependence is associated with a dysregulated dopamine system modulating reward, craving and cognition." | ( Beck, O; Carlsson, A; Franck, J; Guterstam, J; Jayaram-Lindström, N; Khemiri, L; Steensland, P, 2015) |
| "Diagnosis of alcohol use disorders is based on the formal criteria of ICD-10 and DSM-V." | ( Sivolap, YP, 2015) |
| "Ethanol abuse is linked to several acute and chronic injuries that can lead to health problems." | ( Fernandes-Santos, J; Marin, MT; Morais-Silva, G; Moreira-Silva, D, 2016) |
| "Alcohol addiction is one of the most common and devastating diseases in the world." | ( Berrettini, W, 2016) |
| "Alcohol addiction is a major unmet medical and economic issue for which very few efficacious pharmacological treatment options are currently available." | ( Facciol, A; Gerlai, R; Tran, S, 2016) |
| "Alcohol dependence is a public health problem worldwide, commonly associated with withdrawal symptoms for which diazepam is a frequently used drug." | ( Adithan, S; Chandrasekaran, A; Jose, M; Kattimani, S; Mathaiyan, J, 2016) |
| "Alcohol addiction is a heterogeneous psychiatric disorder according to both phenotype and etiology." | ( Cicin-Šain, L; Kovak-Mufić, A; Marušić, S; Matošić, A; Vidrih, B, 2016) |
| "Alcohol dependence is a progressive chronic disorder characterized by narrowing of the drinking repertoire, salience of drinking, tolerance and withdrawal phenomenon, compulsion to drink, and frequent relapses." | ( Arora, S; Elwadhi, D; Gupta, M; Rastogi, R; Verma, P, 2017) |
| "Alcohol use disorders are common in Australia and are often unrecognised." | ( Freyer, CH; Haber, PS; Morley, KC, 2016) |
| "Club drugs and alcohol abuse are prevalent among methadone maintenance treatment (MMT) patients." | ( Andrew, B; Gu, J; Hao, C; Hao, Y; Jiao, M; Liu, D; Xu, H; Zhang, X; Zhao, Y, 2017) |
| "Alcohol use disorders are frequently associated with self-intoxication in attempted suicide." | ( Cardona, F; de Haro, L; Franchitto, N; Pelissier, F; Picot, C; Puskarczyk, E; Sapori, JM; Tournoud, C, 2017) |
| "The development of alcohol dependence is associated with significant morbidity and mortality." | ( Goh, ET; Morgan, MY, 2017) |
| "Worldwide, alcohol abuse is a burgeoning problem." | ( Brandner, B; Lawn, W; McAndrew, A; Morgan, CJ; Porffy, L; Stevens, T, 2017) |
| "Alcohol dependence is more prevalent in men than in women." | ( Beckmann, MW; Behrens, J; Bouna-Pyrrou, P; Braun, B; Eichler, A; Engel, A; Fasching, PA; Goecke, TW; Heinrich, H; Hoppe, U; Huber, SE; Kornhuber, J; Kubis, S; Lenz, B; Mikolaiczik, K; Moll, GH; Mühle, C; Müller, CP; Muschler, MR; Saigali, S; Sibach, M; Tanovska, P; Weinland, C, 2017) |
| "Alcohol dependence is often untreated." | ( Anton, R; Falk, D; Hasin, DS; Kranzler, HR; Litten, R; Mann, K; O'Malley, SS; Robinson, RL; Scodes, J; Wall, M; Witkiewitz, K, 2017) |
| "Alcohol dependence is a major public health issue with a need for new pharmacological treatments." | ( Aubin, HJ; Dano, C; Dematteis, M; Detilleux, M; Paille, F; Reynaud, M; Trinquet, F; Trojak, B; Zakine, B, 2017) |
| "Alcohol dependence is linked to dysregulation of the hypothalamic-pituitary-adrenal axis." | ( Contet, C; Fannon, MJ; Guevara, J; Mandyam, CD; Nguyen, TB; Schmeichel, BE; Sidhu, H; Somkuwar, SS; Vendruscolo, LF; Zorrilla, EP, 2017) |
| "Alcohol use disorders are a leading cause of preventable deaths worldwide, and stress is a major trigger of relapse." | ( Gundlach, AL; Kastman, HE; Krstew, EV; Lawrence, AJ; Walker, LC, 2017) |
| "Alcohol use disorders are associated with patterns of impulsive/risky decision making on behavioral economic decision tasks, but little is known about the factors affecting drinking-related decisions." | ( Bogg, T; Finn, PR; Gerst, K; Lake, A, 2017) |
| "Alcohol addiction is characterized by broad and persistent changes in brain function, but the underlying neural adaptations remain largely unknown." | ( Barbier, E; Heilig, M, 2017) |
| "Given that alcohol use disorder is so often associated with early traumatic experiences, the author is proposing in a current on-going UK-based study that patients with alcohol use disorder who have undergone a medical detoxification from alcohol might benefit from a course of MDMA-assisted psychotherapy." | ( Sessa, B, 2018) |
| "Alcohol addiction is accompanied by aberrant neural activity." | ( De Ridder, D; Huang, Y; Mohan, A; Sunaert, S; Vanneste, S, 2018) |
| "Alcohol use disorders are chronic debilitating diseases characterized by severe withdrawal symptoms that contribute to morbidity and relapse." | ( Besheer, J; Bohnsack, JP; Edokpolor, K; Hughes, BA; Morrow, AL; O'Buckley, TK, 2018) |
| "Alcohol addiction is a chronic neuropsychiatric disorder that represents one of the most serious global public health problems." | ( He, B; Ren, H; Shi, Z; Su, H; Wan, JB; Wang, M; Xie, Y; Yao, X; Yuan, TF, 2019) |
| "Because BD-II and alcohol dependence are neurodegenerative disorders, agents with anti-inflammatory and neurotrophic effects might provide effective therapy." | ( Chang, YH; Chen, KC; Chen, PS; Chen, SL; Hong, JS; Huang, SY; Lee, IH; Lee, SY; Lu, RB; Tzeng, NS; Wang, LJ; Wang, TY; Yang, YK, 2018) |
| "Alcohol use disorders are a leading public health concern, engendering enormous costs in terms of both economic loss and human suffering." | ( Holleran, KM; Jones, SR; Karkhanis, AN; Melchior, JR; Siciliano, CA, 2018) |
| "Alcohol use disorders are characterized by a complex behavioral symptomatology, which includes the loss of control over alcohol consumption and the emergence of a negative affective state when alcohol is not consumed." | ( Contet, C; Kreifeldt, M; Sidhu, H, 2018) |
| "Alcohol dependence is characterised by persistent drinking despite health, social and economic costs." | ( Hardy, L; Hogarth, L, 2018) |
| "Alcohol use disorder is one of the most important factors contributing to dementia." | ( Chang, YH; Chen, YY; Chou, WP; Ko, CH; Lin, HC, 2019) |
| "Alcohol dependence is a major public health problem." | ( Antonsen, KK; Becker, U; Benveniste, H; Brunchmann, AS; Ekstrøm, C; Fahmy, TP; Fink-Jensen, A; Fisher, PM; Jensen, ME; Klausen, MK; Knudsen, GM; le Dous, N; Miskowiak, KW; Rindom, H; Thomsen, GK; Vilsbøll, T; Volkow, ND; Vollstaedt-Klein, S, 2018) |
| "Alcohol use disorder is a persistent condition and relapse rates following successful remission are high." | ( Frye, CCJ; Galizio, A; Haynes, JM; Nall, RW; Odum, AL; Rung, JM, 2018) |
| "Alcohol use disorder is a widespread mental illness characterized by periods of abstinence followed by recidivism, and stress is the primary trigger of relapse." | ( Bertholomey, ML; Logrip, ML; Milivojevic, V; Torregrossa, MM, 2018) |
| "Alcohol dependence is a global public health problem, yet the mechanisms of alcohol dependence are incompletely understood." | ( Fan, Y; Ji-Dong, W; Meng-Yu, M; Rui-Ling, Z; Ya-E, Z; Ya-Lun, S; Ying, Z; Yu-Fan, L, 2018) |
| "Alcohol use disorder is a major societal and individual burden that exacerbates health outcomes, decreases quality of life, and negatively affects U." | ( Brown, ES; Escalante, C; Holmes, T; Ivleva, EI; Kulikova, A; Nakamura, A; Van Enkevort, E, 2019) |
| "Alcohol use disorder is a significant global burden." | ( Cuzon Carlson, VC; Grant, KA; Herman, MA; Jimenez, VA; Roberto, M; Walter, NA, 2019) |
| "Tobacco use and alcohol abuse are associated with higher risk of tuberculosis (TB) infection, progression to active TB and adverse treatment outcomes among patients with TB." | ( Anand, T; Isaakidis, P; Jeyashree, K; Madhukeshwar, AK; Navya, N; Nayarmoole, BM; Nirgude, AS, 2019) |
| "Alcohol abuse is a well-known cause of imbalance in trace element levels and oxidant/antioxidant status of individuals with long time consumption." | ( Akyolcu, MC; Hocaoglu-Emre, FS; Karaman, F; Mırsal, H; Saribal, D, 2020) |
| "Alcohol dependence is frequently comorbid with bipolar I disorder." | ( Hashimoto, T; Kurata, T; Suzuki, H, 2019) |
| "Alcohol use disorder is a serious illness marked by uncontrollable drinking and a negative withdrawal state when not using." | ( Bagdas, D; Bettinger, JC; Damaj, MI; Miles, MF; Wolstenholme, JT; Younis, RM, 2019) |
| "Alcohol use disorder is highly heterogeneous." | ( Baskerville, WA; Bujarski, S; Grodin, EN; Jentsch, JD; Nieto, SJ; Ray, LA; Venegas, A, 2019) |
| "Family history of alcohol use disorder is linked to structural and functional variations including brain regions involved in reward processes." | ( Airagnes, G; Artiges, E; Dubol, M; Filippi, I; Frère, P; Guérin-Langlois, C; Guillon, F; Hoertel, N; Lemaître, H; Limosin, F; Martinot, JL; Rahim, M; Seigneurie, AS, 2019) |
| "Alcohol use disorder is a destructive compulsion characterized by chronic relapse and poor recovery outcomes." | ( Kareken, DA; Oberlin, BG; Shen, YI, 2020) |
| "Alcohol addiction is one of the highly prevalent neurological disorders and a major threat to public health in the 21st century." | ( Agrawal, S; Chouhan, D; Gadepalli, A; Purohit, N; Roy, TK; Shaw, S; Tiwari, V; Uniyal, A, 2020) |
| "Alcohol dependence is one of the psychiatric disorders affecting over 1 million people in Japan." | ( Ohgi, Y, 2020) |
| "Alcohol use disorder is a complex neuropsychiatric disorder affecting both males and females worldwide; however, the efficacy of current pharmacotherapies varies." | ( Egecioglu, E; Jerlhag, E; Kalafateli, AL; Raun, K; Vestlund, J, 2021) |
| "Alcohol dependence is a chronic and severe health problem which puts a heavy burden on society." | ( Huang, Y; Li, JX; Liu, J; Wang, K; Wu, R; Zhang, Y, 2020) |
| "Alcohol abuse is the cause of many liver diseases, such as steatosis, alcoholic steatohepatitis, fibrosis, cirrhosis, and, potentially, hepatocellular cancer." | ( Baburina, Y; Krestinina, O; Odinokova, I, 2020) |
| "The role of alcohol abuse is common in the onset of cancer of the upper aerodigestive tract, especially that affecting the tongue, floor of the mouth, palatine tonsil and piriform sinus." | ( Crescenzi, D; Croce, A; Laus, M; Radici, M; Trignani, M, 2020) |
| "Alcohol use disorder is highly comorbid with other neuropsychiatric disorders such as depression and anxiety." | ( Bloch, S; Marcus, MM; Mulholland, PJ; Rinker, JA, 2020) |
| "Rates of alcohol use disorders are increasing in women, and there is growing evidence that both the cognitive and biological consequences of alcohol dependence are distinct in women as compared to men." | ( Barker, JM; Chandran, K; Figueroa, LA; Giacometti, LL, 2020) |
| "Alcohol dependence is a significant issue contributing to disease burden." | ( Coleman, R; Coulton, S; Donoghue, K; Drummond, C; Little, H; Milward, J; Philips, T; Rose, A, 2020) |
| "Chronic alcohol abuse is common and a leading cause of alcoholic liver disease (ALD)." | ( Kim, SH; Park, KH, 2020) |
| "Alcohol use disorders are chronic and highly relapsing disorders, thus alcoholic patients have a high rate of recidivism for drug use even after long periods of abstinence." | ( Cano-Cebrián, MJ; Fernández-Rodríguez, S; Granero, L; Hipólito, L; Polache, A; Zornoza, T, 2021) |
| "Alcohol use disorder is a common and devastating mental illness for which satisfactory treatments are still lacking." | ( Bach, P; Bumb, JM; Dinter, C; Hermann, D; Karl, D; Kiefer, F; Koopmann, A; Mann, K; Vollstädt-Klein, S, 2021) |
| "The etiology of alcohol dependence is not completely understood." | ( Ding, Y; Ishaq, HM; Li, D; Lu, Y; Shen, M; Wang, Q; Wei, J; Yan, D; Yang, F; Zhang, R, 2021) |
| "Alcohol use disorder is a multifactorial undertreated chronic disorder influenced by genetic, psychological, and environmental factors." | ( Harries, B; Harries, J; Motluk, L; Szelest, I, 2021) |
| "Alcohol dependence is a chronic relapsing mental disorder with heterogeneous and complex underlying biology." | ( Bektic Hodzic, J; Kozumplik, O; Mimica, N; Nedic Erjavec, G; Nikolac Perkovic, M; Pivac, N; Repovecki, S; Svob Strac, D; Tudor, L; Uzun, S, 2021) |
| "Many patients with alcohol use disorders are challenged by cravings leading to repeated relapses." | ( Larsen, MB; Mejldal, A; Mellentin, AI; Nielsen, AS; Nielsen, B; Nielsen, DG; Sibbersen, C; Stenager, E; Stryhn, L, 2022) |
| "Alcohol use disorder is argued to be a highly complex disorder influenced by a multitude of factors on different levels." | ( Goudriaan, AE; Huth, KBS; Luigjes, J; Marsman, M; van Holst, RJ, 2022) |
| "Alcohol use disorders are prevalent in the USA and throughout the world." | ( Bleiweis, M; Jones, JT; Lewis, B; Mason, D; Reisfield, GM; Teitelbaum, SA, 2023) |
| "In addition to DM, alcohol abuse is also a risk factor for many cancers." | ( Lam, BQ; Morvant, J; Shankar, S; Srivastava, R; Srivastava, RK, 2021) |
| "Stigma towards alcohol use disorders is prevalent in India and can lead to social exclusion and hamper treatment access and outcomes." | ( Kumar, S; Nadkarni, A; Schess, J; Velleman, R, 2022) |
| "Alcohol use disorders are complex, multifactorial phenomena with a large footprint within the global burden of diseases." | ( Claridge-Chang, A; Goel, T; Kibat, C; Mathuru, AS; Nathan, FM; Stewart, J, 2022) |
| "Alcohol use disorder is characterised by disrupted reward learning, underpinned by dysfunctional cortico-striatal reward pathways, although relatively little is known about the biology of reward processing in populations who engage in risky alcohol use." | ( Cao, Z; Fouragnan, EF; Ganis, G; Komarnyckyj, M; Murphy, A; Retzler, C; Whelan, R, 2022) |
| "Chronic alcohol abuse is now recognized as a factor complicating the course of acute respiratory distress syndrome and increasing mortality." | ( Catravas, JD; Colunga Biancatelli, RML; Solopov, PA, 2022) |
| "Alcohol abuse is 1 of the most significant public health problems in the world." | ( Cong, Y; Hou, X; Rong, C; Song, S; Zhang, HT; Zhang, Q, 2023) |
| "Alcohol use disorder is highly prevalent and has important economical, societal, psychiatric, and medical consequences." | ( Garel, N; Greenway, KT; Jutras-Aswad, D; Lesperance, P; McAnulty, C; Miron, JP; Rej, S; Richard-Devantoy, S, 2022) |
| "Alcohol use disorder is a major public health concern in the United States." | ( Catavero, CM; Downs, AM; Kasten, MR; McElligott, ZA, 2023) |
| "Alcohol use disorder is a difficult-to-treat psychiatric disorder and a major burden on public health." | ( Ekstrøm, CT; Fink-Jensen, A; Fisher, PM; Jensen, ME; Juul, TS; Knudsen, GM; Stenbæk, DS, 2022) |
| "Alcohol dependence is associated with difficulties in processing emotional stimuli, which can lead to interpersonal problems." | ( Aamo, TO; Gråwe, RW; Melby, K; Quintana, DS; Spigset, O, 2022) |
| "Alcohol use disorder is a major cause of morbidity, which requires newer treatment approaches." | ( Bajaj, JS; Cheng, PC; Fagan, A; Gillevet, PM; González-Maeso, J; Herzog, J; Hylemon, PB; Kang, JD; Peña-Rodríguez, M; Sartor, RB; Saunders, JM; Shamsaddini, A; Sikaroodi, M; Smith, M; Su, L; Tai, YL; Wolstenholme, JT; Zhao, D; Zheng, J; Zhou, H, 2022) |
| "Alcohol addiction is one of the most common health problems." | ( Bieńkowski, P; Jakubczyk, A; Mierzejewski, P; Samochowiec, J; Silczuk, A; Wojnar, M, 2022) |
| "Ethanol abuse is a major public issue globally and withdrawal of ethanol after chronic exposure contributes to the development of behavioural changes." | ( Du, L; Huang, J; Xiao, L; Zou, C, 2022) |
| "Ethanol abuse is a major public issue globally and withdrawal of ethanol after chronic exposure contributes to the development of behavioural changes." | ( Du, L; Huang, J; Xiao, L; Zou, C, 2022) |
| "Ethanol abuse is a major public issue globally and withdrawal of ethanol after chronic exposure contributes to the development of behavioural changes." | ( Du, L; Huang, J; Xiao, L; Zou, C, 2022) |
| "Alcohol use disorder is associated with altered neuron function including those in orbitofrontal cortex (OFC) and basolateral amygdala (BLA) that send glutamatergic inputs to areas of the dorsal striatum (DS) that mediate goal and habit directed actions." | ( Gioia, D; Glaser, CM; Lopez, MF; Nimitvilai-Roberts, S; Woodward, JJ, 2023) |
| "Alcohol use disorder is prevalent globally and in Kenya, and is associated with significant health and socio-economic consequences." | ( Andale, T; Aruasa, WK; Gakinya, B; Jaguga, F; Kerema, J; Kinyanjui, D; Kirwa, P; Kwobah, C; Kwobah, EK; Manji, I; Mwangi, F; Songok, J; Temet, E; Werunga, K, 2023) |
| "Indeed, their alcohol dependence is associated with numerous physical and mental health problems along with strikingly high rates of alcohol-related mortality." | ( Brulotte, A; Flores-Aranda, J; Incio-Serra, N; Motta-Ochoa, R, 2023) |
| "Alcohol use disorder is a chronic situation characterized by a protracted low-grade inflammation." | ( Fernández-Rodríguez, CM; Godoy-Reyes, AM; González-Navarrete, L; González-Reimers, E; Martín-González, C; Martínez-Riera, A; Pérez-Hernández, O; Ribot-Hernández, I; Rodríguez-Gaspar, M, 2023) |
| "Alcohol dependence is a chronic, relapsing encephalopathy characterized by compulsive craving for alcohol, loss of control over alcohol use, and the presence of negative emotions and physical discomfort when alcohol is unavailable." | ( Bai, S; Huang, X; Li, X; Qi, X; Sun, G; Wu, C; Zhao, H; Zheng, Y; Zhu, X, 2023) |
| "Alcohol dependence is characterized by a gradual reduction in cognitive control and inflexibility to contingency changes." | ( Bach, P; Canals, S; De Santis, S; Ghorbanzad-Ghaziany, Z; Halli, P; Kiefer, F; Kirsch, P; Marcos, E; Moratal, D; Pérez-Cervera, L; Pérez-Ramírez, Ú; Pfarr, S; Selim, MK; Sommer, WH; Trouvé-Carpena, A, 2023) |
| "Alcohol dependence is characterized by the abnormal release of dopamine in the brain reward-related areas." | ( Bulska, E; Frycz, BA; Hoener, MC; Kaczmarek, L; Konopka, A; Nowicka, K; Stefaniuk, M, 2023) |
| "Alcohol dependence is a chronic condition impacting millions of individuals worldwide." | ( Conigrave, JH; Conigrave, KM; Lee, KSK; Purcell-Khodr, G; Vnuk, J, 2023) |
| "Alcohol Use Disorder is a complex genetic disorder, involving genetic, neural, and environmental factors, and their interactions." | ( Agrawal, A; Bucholz, KK; Dick, D; Edenberg, HJ; Gameiro-Ros, I; Goate, AM; Hart, RP; Kamarajan, C; Liu, Y; Pang, ZP; Popova, D; Porjesz, B; Prytkova, I; Slesinger, PA; Tischfield, JA; Xuei, X, 2023) |
| "Patients with alcohol use disorders are commonly identified and managed in the emergency department." | ( Gorchynski, J; Knight-Dunn, L, 2023) |
| "A key facet of alcohol use disorder is continuing to drink alcohol despite negative consequences (so called "aversion-resistant drinking")." | ( Ardinger, CE; Kruger, R; Lapish, CC; Timme, NM; Weir, SDC; Zelaya-Escobar, R, 2024) |
| Excerpt | Reference |
|---|
| "Forty patients with a history of alcohol abuse were treated with a 2% solution of methacholine to determine the prevalence of iridic parasympathetic denervation." | ( Myers, W; Reeves, A; Willis, K, 1979) |
| "A treatment population of 1,544 drug/alcohol abusers at 10 combined treatment centers was studied to determine the various patterns of sequential use and their corresponding policy implications." | ( Greene, BT, 1979) |
| "Evidence exists that alcohol abuse frequently coexists with narcotic addiction and methadone maintenance treatment, and it is the major factor in the development of cirrhosis and liver failure." | ( Anand, OP; Gelb, AM; Richman, BL, 1978) |
| "In treatment of alcohol dependence, disulfiram is most useful in conjunction with a structured, supervised, aftercare program." | ( Larson, EW; Morse, RM; Olincy, A; Rummans, TA, 1992) |
| "The results for both alcohol dependence and cocaine dependence were positive, but there was no evidence of a significant advantage for one treatment environment over the other." | ( Alterman, A; Childress, AR; McLellan, AT; O'Brien, CP, 1992) |
| "If untreated, alcohol abuse, which often results from alcohol craving, causes major metabolic abnormalities, altered life-styles, lost productivity, and eventually death." | ( Biery, JR; McMullen, EA; Williford, JH, 1991) |
| "The diagnosis of other drug and alcohol dependence in cocaine dependence and in family members of cocaine dependents has important impact on etiology, prognosis and treatment." | ( Belkin, BM; Gold, MS; Klahr, AL; Miller, NS, 1989) |
| "Mixed opioid and alcohol abusers did poorly in standard alcohol abstinence treatment, compared to matched alcoholics without opiate abuse histories." | ( Cushman, P, 1987) |
| "Correction of obesity and alcohol abuse are confirmed methods of treating hypertension." | ( Borgman, RF, 1985) |
| "When alcohol abuse occurs with depression, both the substance abuse and the mood disorder necessitate treatment." | ( Lippmann, S; Pary, R; Tobias, CR, 1988) |
| "Not one patient was referred for alcohol abuse evaluation or treatment." | ( Astrachan, BM; Chang, G, 1988) |
| "Recently detoxified men with alcohol dependence (n = 15) and healthy volunteers (n = 14) were administered oral and intravenous imipramine and desipramine." | ( Barnhill, JG; Ciraulo, DA; Jaffe, JH, 1988) |
| "When alcohol abuse occurs in association with anxiety, depression, or schizophrenia, treatment with the anxiolytic, antidepressant, and neuroleptic drugs, respectively, may facilitate the alcoholic's ability to participate in other programs." | ( Annis, A; Peachey, JE, 1984) |
| "Alcohol intake was monitored daily and alcohol dependence (ADS) and problems (MAST) were assessed at intake and post-treatment." | ( Bremner, KE; Lanctôt, KL; Naranjo, CA, 1995) |
| "Detecting and treating alcohol abuse, depression, or life stress may then make it easier to motivate the patient to quit smoking." | ( Randolph, JF; Timmreck, TC, 1993) |
| "Thirteen of these patients with alcohol abuse were treated postoperatively with IV clonidine for prevention of alcohol withdrawal syndrome." | ( Goeters, C; Kuhmann, M; Mertes, N; Zander, JF, 1996) |
| "Major depression secondary to alcohol dependence that is diagnosed after at least 1 week of abstinence can remain stable in some placebo-treated alcoholics and can respond to desipramine." | ( Cutler, RB; Kocsis, JH; Mason, BJ; Ritvo, EC, 1996) |
| "The neurobehavioural model of alcohol dependence implies that combinations of medications may lead to more effective treatment; thus, identifying subtypes of alcoholic patients will be important in determining which therapies or combinations of therapy will be most effective in treating alcohol dependence." | ( Anton, RF, 1996) |
| "Standard treatment for alcohol abuse may include pharmacotherapy to alleviate withdrawal symptoms followed by psychotherapy in inpatient and/or outpatient settings." | ( Mann, K, 1996) |
| "Twenty-eight male patients with severe alcohol dependence (mean pretreatment consumption of 18." | ( Kabel, DI; Petty, F, 1996) |
| "Pharmacological treatments for alcohol dependence have focused increasingly on agents that reduce alcohol craving and consumption or that treat psychiatric disorders associated with drinking relapse." | ( Mason, BJ, 1996) |
| "Patients with alcohol addiction are analyzed after one year from the beginning of therapy." | ( Becagli, A; Cecchetti, E; Cimarosti, P; Costella, V; Santonastaso, M; Tagliamento, A; Zanatta, N, 1997) |
| "The neurobehavioural model of alcohol dependence implies that combinations of medications may lead to more effective treatment; thus, identifying subtypes of alcoholic patients will be important in determining which therapies or combinations of therapy will be most effective in treating alcohol dependence." | ( Anton, RF, 1996) |
| "Standard treatment for alcohol abuse may include pharmacotherapy to alleviate withdrawal symptoms followed by psychotherapy in inpatient and/or outpatient settings." | ( Mann, K, 1996) |
| "Motivated individuals with moderate alcohol dependence can be treated with greater effectiveness when naltrexone is used in conjunction with weekly outpatient cognitive behavioral therapy." | ( Anton, RF; Dias, JK; Latham, PK; Malcolm, RJ; Moak, DH; Waid, LR, 1999) |
| "Cross-sectional study with a group of alcohol abusers in treatment (n = 259, 56 women) at the Bergen Clinics Foundation, Norway." | ( Skutle, A, 1999) |
| "However, the development of alcohol dependence has not been explored in rats that self-administer ethanol for less than 15-20 weeks." | ( Gause, L; Kampov-Polevoy, AB; Matthews, DB; Morrow, AL; Overstreet, DH, 2000) |
| "NTX has some benefits for patients with alcohol dependence, but patients' adherence to treatment should be of concern." | ( Jarusuraisin, N; Srisurapanont, M, 2000) |
| "Subtyping those with alcohol dependence on the basis of the absence versus the presence of a lifetime depressive disorder may help to resolve conflicting findings in the literature on the treatment of alcohol dependence with serotonergic medications." | ( Cnaan, A; Kranzler, HR; Luck, G; Pettinati, HM; Rukstalis, MR; Volpicelli, JR, 2001) |
| "The Drive for Thinness scale, the Alcohol Use Disorders Identification Test and the BIS/BAS scales were administered to 232 high school girls." | ( Dawe, S; Loxton, NJ, 2001) |
| "Naltrexone treatment of alcohol dependence is associated with adverse events that may limit its effectiveness." | ( Kranzler, HR; Oncken, C; Van Kirk, J, 2001) |
| "Therefore, pharmacologic treatments for alcohol dependence may be targeted to numerous pathways." | ( Anton, RF, 2001) |
| "105 patients with severe alcohol dependence, who were treated in 13 centers in Switzerland, took part in this open study." | ( Fuchs, WJ; Riebenfeld, D, 2002) |
| "NMF has no role for the treatment of alcohol dependence in clinical practice." | ( Jarusuraisin, N; Srisurapanont, M, 2002) |
| "Individuals with alcohol dependence (n = 8) and alcohol abuse (n = 4) who were not seeking treatment were recruited by advertisement and participated in two test days, 1 week apart." | ( Boutros, NN; Buonopane, A; Cermik, O; Krystal, JH; Limoncelli, D; O'Malley, S; Petrakis, IL; Trevisan, L, 2002) |
| "Smokers with a history of alcohol dependence may have more difficulty quitting, might relapse to alcohol use, and might especially benefit from nicotine replacement therapy for smoking cessation." | ( Callas, PW; Hatsukami, DK; Hughes, JR; Jensen, J; Novy, P, 2003) |
| "In 1997, the National Institute on Alcohol Abuse and Alcoholism recruited 11 sites and a coordinating center for a large-scale (1,375 subjects), randomized placebo controlled trial to test 16 weeks of active treatment using naltrexone and acamprosate alone and in combination." | ( , 2003) |
| "In several studies, patients with alcohol dependence treated with the opioid antagonist naltrexone have shown fewer relapses to heavy drinking than those receiving placebo." | ( Balldin, J; Bendtsen, P; Berglund, M; Borg, S; Franck, J; Gustafsson, L; Halldin, J; Månsson, M; Nilsson, LH; Stolt, G; Willander, A, 2003) |
| "The development of treatments for alcohol dependence has been significantly complicated by the multiple actions of ethanol at the neurotransmitter level, heterogeneity among patients with alcohol dependence, the complexity of defining and measuring the phenomenon of craving, and the challenge of quantifying alcohol intake in patients." | ( Johnson, BA, 2004) |
| "The early identification of alcohol abuse could increase the possibility of a favorable treatment outcome and reduce health care costs." | ( Chrostek, L; Cylwik, B; Szmitkowski, M, 2004) |
| "The neurobiological basis of alcohol dependence, established pharmacotherapies for alcohol dependence, pharmacotherapies under investigation, and obstacles to treatment are discussed." | ( Kenna, GA; McGeary, JE; Swift, RM, 2004) |
| "A 19-y-o man with a history of alcohol abuse ingested a 10 mL bottle of "Soluto Vital" (tartar emetic, 50 mg/mL), produced in Guatemala for treatment of alcohol abuse." | ( Hoffman, RS; Khan, Y; Nelson, LS; Tarabar, AF, 2004) |
| "For the National Institute on Alcohol Abuse and Alcoholism COMBINE Study, testing the safety and efficacy of naltrexone and acamprosate, both alone and in combination, in the treatment of alcohol dependence, we adapted a standardized instrument--the Systematic Assessment for Treatment Emergent Events (SAFTEE)--for assessing adverse events in these Phase 2- to Phase 3-type studies." | ( Ait-Daoud, N; Johnson, BA; Roache, JD, 2005) |
| "Medications for treating alcohol dependence primarily have been adjunctive interventions, and only three medications--disulfiram, naltrexone, and acamprosate--are approved for this indication by the U." | ( Williams, SH, 2005) |
| "We examined 172 patients with alcohol dependence (137 men, 35 women) during withdrawal treatment." | ( Bayerlein, K; Bleich, S; Bönsch, D; Frieling, H; Hillemacher, T; Kornhuber, J; von Ahsen, N; Wilhelm, J; Ziegenbein, M, 2005) |
| "%CDT is used as a marker of both alcohol use disorder severity and treatment outcome both clinically and in treatment trials." | ( Anton, RF; Youngblood, M, 2006) |
| "In the treatment of alcohol dependence, we found that 19 (70%) of 27 clinical trials that measured reductions in "heavy or excessive drinking" demonstrated an advantage for prescribing naltrexone over placebo, whereas only 9 (36%) of 25 clinical trials that measured abstinence or "any drinking" found an advantage for medication over placebo." | ( Dackis, CA; Kampman, KM; O'Brien, CP; Oslin, DW; Pettinati, HM; Rabinowitz, AR; Wortman, SP, 2006) |
| "Pharmacotherapy of alcohol dependence (AD) is at an early stage of development; currently available medications have limited efficacy." | ( Cramer, J; Gelernter, J; Gueorguieva, R; Kranzler, HR; Krystal, JH; Rosenheck, R; Zhang, H, 2007) |
| "One of the difficulties in treating alcohol dependence is its adverse effect on the brain, as higher aspects of cortical function necessary to maintain abstinence are eroded by alcohol." | ( Bankes, L; Brown, TM; Guzik, P, 2007) |
| "One of the most severe consequences of alcohol dependence is the withdrawal syndrome, for which benzodiazepines are the most popular current treatment." | ( Gillman, MA; Lichtigfeld, FJ; Young, TN, 2007) |
| "Benefits in the treatment of alcohol dependence might be optimized by matching the efficacy profiles of specific antidipsotropics with the motivational status of alcohol-dependent patients." | ( Lehert, P; Leucht, S; Rösner, S; Soyka, M, 2008) |
| "Naltrexone hydrochloride treatment for alcohol dependence works for some individuals but not for everyone." | ( Anton, RF; Couper, D; Goldman, D; O'Malley, S; Oroszi, G; Pettinati, H; Swift, R, 2008) |
| "The National Institute on Alcohol Abuse and Alcoholism COMBINE (Combining Medications and Behavioral Interventions) study, a randomized controlled double-blind trial of 1,383 alcohol-dependent patients, compared combinations of medications (acamprosate [Campral] and naltrexone [ReVia]) and behavioral therapy (medical management and specialist-delivered behavioral therapy) for alcohol dependence." | ( Hosking, JD; Locastro, JS; O'malley, SS; Swift, R; Weiss, RD, 2008) |
| "Women treated for alcohol addiction have mortality rates three to five times those of women from the general population (GP)." | ( Franck, J; Gjestad, R; Haver, B; Lindberg, S, 2009) |
| "First-time-treated women with alcohol addiction have a substantially lower mortality than reported previously from clinical samples, except for the youngest group." | ( Franck, J; Gjestad, R; Haver, B; Lindberg, S, 2009) |
| "Effective treatment choices for alcohol dependence have existed for long, but only a minor proportion of those dependent on alcohol seeks medical care and receives effective treatment." | ( Alho, H; Hyytiä, P, 2009) |
| "In the pharmacological treatment of alcohol dependence long-lasting benzodiazepines or clomethiazole for alcohol withdrawal, and acamprosate or naltrexone for relapse prevention are preferable." | ( Walter, M; Wiesbeck, GA, 2009) |
| "Improved treatment of alcohol dependence is a high priority, including defining subtypes that might respond differently." | ( Anton, RF; Baros, AM; Latham, PK; Malcolm, R; Myrick, H; Randall, PK; Stewart, SH; Waid, R; Wright, TM, 2009) |
| "Recently, TP has been used to treat alcohol dependence, but it is still not known whether the effects of TP on alcohol consumption are related with its action on impulsivity." | ( Manzanares, J; Martínez-Gras, I; Rubio, G, 2009) |
| "Eligible patients are diagnosed with alcohol abuse or dependence, are newly diagnosed with TB, and initiating treatment in the TOTBS with Directly Observed Therapy-Short Course (DOTS) for TB." | ( Connery, HS; Fitzmaurice, G; Greenfield, SF; Lastimoso, CS; Livchits, V; Mathew, TA; Mishustin, SP; Shields, A; Shin, S; Strelis, AK; Yanov, SA, 2010) |
| "Alcoholism and other alcohol use disorders are major public health problems, and the success rates of non-pharmacological treatment of these disorders such as psychotherapy, cognitive-behavioral therapy, group therapy, or residential treatment programs,remain only modest at best." | ( Olive, MF, 2010) |
| "At least 60% of those treated for an alcohol use disorder will relapse." | ( Buckley, S; Durazzo, TC; Fryer, SL; Gazdzinski, S; Meyerhoff, DJ; Mon, A; Tosun, D, 2011) |
| "Empirically-supported treatments for alcohol dependence exist, yet understanding of influences contributing to the intended behavior change is limited." | ( Donovan, D; Hartzler, B; Villarroel, N; Witkiewitz, K, 2011) |
| "Treatment of alcohol use disorders (AUD) is based on the application of combined approaches, including pharmacological intervention directed to different molecular targets." | ( Coveñas, R; Rodriguez, FD, 2011) |
| "The lack of satisfactory results of alcohol dependence treatment force us to search for new directions of research." | ( Dunaj, A; Piątkowska, K; Pietrzak, B, 2011) |
| "Pharmacotherapy studies in alcohol dependence (AD) are generally of short duration and do not include post-treatment follow-up." | ( Armeli, S; Kranzler, HR; Tennen, H, 2012) |
| "Comorbid alcohol use disorder was associated with an increased risk of natural death, whereas administration of antipsychotic drugs was not associated with lowered risk." | ( Chen, CC; Chen, WJ; Conwell, Y; Huang, MC; Kuo, CJ; Lee, WC; Liao, YT; Lin, SK; Tsai, SY, 2012) |
| "20 patients suffering from alcohol addictions starting a detoxification therapy have been included in a prospective, randomized, double blind study." | ( Boben-Bardutzky, D; Hafner, M; Ihan, A; Jukić, T; Rojc, B, 2011) |
| "Cigarette smoking predicts more severe alcohol dependence and poorer treatment response in general." | ( Fucito, LM; Gueorguieva, RV; Gulliver, SB; Mattson, ME; O'Malley, SS; Park, A, 2012) |
| "Patients with alcohol dependence in intensive day treatment (n=165) were participating in a randomized trial of naltrexone versus placebo and adjunctive communication and coping skills training or a control treatment." | ( Dolan, SL; Martin, RA; Monti, PM; Rohsenow, DJ, 2013) |
| "The acute and maintenance treatment of alcohol addiction represents the clinical challenge." | ( Horacek, J; Janu, L; Rackova, S, 2012) |
| "All participants got alcohol dependence rehabilitation treatment for 30 days, and then we compared changes in BDNF, ghrelin, and leptin between pre- and post-alcohol abstinence." | ( Cheon, YH; Ju, A; K, M; Kim, DJ; Kim, JH; Kim, SJ; Lee, SS; Lee, WY, 2013) |
| "Comorbid chronic stress and alcohol dependence may lead to a complicated and potentially severe treatment profile." | ( Bahi, A, 2013) |
| "There is a large treatment gap in alcohol dependence, and current treatments are only moderately effective in preventing relapse." | ( Bladström, A; Gual, A; Mann, K; Torup, L; van den Brink, W, 2013) |
| "In Poland the main treatment method of alcohol addiction is psychotherapy practiced in the rehab centers." | ( Kuźniar-Placek, J; Panasiuk, L; Szponar, J, 2012) |
| "Adult men with a diagnosis of alcohol dependence (n = 18) were recruited from outpatient treatment units for alcoholism." | ( Balldin, J; Berggren, U; Berglund, KJ; Fahlke, C; Gerdner, A, 2013) |
| "Given the high prevalence of alcohol dependence in our view disulfiram is used very little, although the use of disulfiram in the context of structured, multi-modal outpatient treatment programs are considered to be safe." | ( Kiefer, F; Mutschler, J, 2013) |
| "Total of 239 patients treated from alcohol addiction in Addiction Treatment Center (OTU) Parzymiechy, Poland were included in the study." | ( Goniewicz, J; Goniewicz, MŁ; Kośmider, L; Kozar-Konieczna, A; Olszowy, Z; Ptak, M; Sobczak, A; Szołtysek-Boldys, I; Słodczyk, E, 2012) |
| "Developing pharmacotherapies to treat alcohol dependence and associated health problems traditionally has been based on gaining a better understanding of the neuroscience underlying alcohol-drinking behavior." | ( Krishnan-Sarin, S; Krystal, JH; O'Malley, S, 2008) |
| "The efficacy of medications for alcohol dependence remains modest, and there are no strong clinical predictors of treatment response." | ( Franck, J; Jayaram-Lindström, N, 2013) |
| "In this study of patients with alcohol dependence and PTSD, naltrexone treatment resulted in a decrease in the percentage of days drinking." | ( Bux, DA; Foa, EB; Imms, P; McLean, CP; O'Brien, CP; Oslin, D; Riggs, DS; Suvak, MK; Volpicelli, J; Yusko, DA, 2013) |
| "Effective treatments for alcohol use disorders in those with significant liver disease are critically lacking." | ( Baillie, A; Haber, PS; Leung, S; Morley, KC, 2013) |
| "Individuals with alcohol dependence (n = 32) completed a randomized, single-blinded, intravenous alcohol administration in the laboratory in which subjective responses to the alcohol were measured, followed by a visit to the laboratory 1 month later to complete the DAQ." | ( Ashenhurst, J; Bacio, G; Bujarski, S; Courtney, KE; Hartwell, E; Moallem, N; Ray, LA, 2013) |
| "In the alcohol dependence group, median duration of baclofen treatment was 143." | ( Dupouy, J; Fournier, JP; Jouanjus, É; Lapeyre-Mestre, M; Oustric, S; Palmaro, A; Poutrain, JC, 2014) |
| "Disulfiram treatment for alcohol dependence is used with acceptable outcomes." | ( Amuchastegui, M; Amuchastegui, T; Donohue, T, 2014) |
| "Several treatments for alcohol dependence have been tested in randomized controlled trials, giving rise to systematic reviews with a network of evidence structure, or mixed treatment comparisons (MTCs)." | ( DeSantis, SM; Zhu, H, 2014) |
| "Naltrexone is effective to treat alcohol dependence (decreased length and frequency of drinking bouts), but its severe side effects, including withdrawal symptoms, are difficult to overcome." | ( Liang, J; Olsen, RW, 2014) |
| "Evidence suggests that alcohol dependence may be influenced by a genetic interaction that may be gender-specific with temporal changes making pharmacological treatment with serotonergic drugs complex." | ( Beaucage, K; Brickley, M; Clifford, JS; Fricchione, S; Haass-Koffler, CL; Kenna, GA; Leggio, L; McGeary, JE; Shoaff, JR; Swift, RM; Zywiak, WH, 2014) |
| "Individuals with alcohol use disorders (AUDs) have deficits in cognitive control, but how they change with treatment is unclear." | ( Bogenschutz, MP; Cumbo, H; Dekonenko, C; Ling, J; Mayer, AR; Wilcox, CE, 2015) |
| "Decreasing stigmatisation of alcohol use disorder through public service announcements, in addition to more flexible physician attitudes concerning personal alcohol intake objectives may be key in getting increased numbers of patients into treatment programmes." | ( Bendimerad, P; Blecha, L, 2014) |
| "Depression commonly co-occurs with alcohol use disorders but predictors of depression treatment outcome in patients with both conditions are not well established." | ( Adamson, SJ; Boden, JM; Douglas Sellman, J; Foulds, JA; Joyce, PR; Mulder, RT, 2015) |
| "Ten volunteers with DSM-IV alcohol dependence received orally administered psilocybin in one or two supervised sessions in addition to Motivational Enhancement Therapy and therapy sessions devoted to preparation for and debriefing from the psilocybin sessions." | ( Barbosa, PC; Bogenschutz, MP; Forcehimes, AA; Pommy, JA; Strassman, RJ; Wilcox, CE, 2015) |
| "Forty adults with co-occurring alcohol dependence and serious mental illnesses submitted 1068 urine samples over a 16-week alcohol treatment study." | ( Angelo, FA; Leickly, E; Lowe, JM; McDonell, MG; McPherson, S; Ries, RK; Roll, JM; Srebnik, D; Vilardaga, R, 2015) |
| "Most treatment programs for alcohol dependence have prioritized alcohol abstinence as the primary treatment goal." | ( Collins, SE; Dean, PE; Grazioli, VS; Greenleaf, SM; Haelsig, L; Hatsukami, AS; Herndon, P; Hoffman, GE; Jones, CB; Koker, MJ; Taylor, EM; Torres, NI; Zhu, MD, 2015) |
| "New strategies for the treatment of alcohol dependence are a pressing need, and recent evidence suggests that targeting enzymes involved in epigenetic mechanisms seems to have great potential." | ( Alaux-Cantin, S; Jeanblanc, J; Jeanblanc, V; Lemoine, S; Naassila, M, 2015) |
| "The treatment of alcohol dependence (AD) with sodium oxybate (SMO) was introduced in Italy and Austria more than 20 years and 15 years ago respectively, and it is now widely employed." | ( Addolorato, G; Bernardi, M; Caputo, F; Ceccanti, M; Cibin, M; Domenicali, M; Maremmani, I; Mirijello, A; Mosti, A, 2015) |
| "Insomnia in patients with alcohol dependence has increasingly become a target of treatment due to its prevalence, persistence, and associations with relapse and suicidal thoughts, as well as randomized controlled studies demonstrating efficacy with behavior therapies and non-addictive medications." | ( Brower, KJ, 2015) |
| "The treatment of alcohol dependence (AD) is a complex activity as the variables are numerous; however, those which must necessarily be taken into account are the type of AD, the internal comorbidities and the presence of any psychiatric comorbidity." | ( Borro, P; Leone, S; Testino, G, 2016) |
| "Alcoholism, or alcohol use disorder, is a major public health concern that is a considerable risk factor for morbidity and disability; therefore, effective treatments are urgently needed." | ( Belanoff, JK; Edwards, S; Estey, D; George, O; Goodell, V; Hunt, HJ; Koob, GF; Logrip, ML; Macshane, LG; Mason, BJ; McGinn, MA; Sanna, PP; Schlosburg, JE; Vendruscolo, LF; Zamora-Martinez, ER, 2015) |
| "While pharmacological treatments for alcohol dependence and relapse targeting the glutamatergic system have shown great promise in preclinical models, more research is needed to uncover novel, possibly circuit-specific, therapeutic targets that exhibit improved efficacy and reduced side effects." | ( Burnett, EJ; Chandler, LJ; Trantham-Davidson, H, 2016) |
| "32 patients with alcohol dependence had been randomized into one of two treatment groups (16 patients in each): patients of the 1st group were treated with baclofen (50 mg/day) for 3 months while patients of the 2nd one received identically looking placebo." | ( Alexeeva, YV; Berntsev, VA; Chekhlaty, EI; Kiselev, AS; Krupitsky, EM; Neznanov, NG; Popov, YV; Rybakova, KV; Zubova, EY, 2015) |
| "A total of 121 adults with alcohol use disorders and co-occurring psychiatric disorders took part in an alcohol treatment study." | ( Battalio, S; Leickly, E; McDonell, MG; McPherson, S; Nepom, JR; Ries, RK; Roll, J; Skalisky, J; Srebnik, D, 2015) |
| "Nalmefene is a recent option in alcohol dependence treatment." | ( Bellissant, E; Boussageon, R; Laviolle, B; Naudet, F; Palpacuer, C; Reymann, JM, 2015) |
| "The value of nalmefene for treatment of alcohol addiction is not established." | ( Bellissant, E; Boussageon, R; Laviolle, B; Naudet, F; Palpacuer, C; Reymann, JM, 2015) |
| "Disproportionately high rates of alcohol use disorders are present in many American Indian/Alaska Native (AI/AN) communities, yet little information exists regarding the effectiveness of alcohol treatments in AI/AN populations." | ( Buchwald, D; Calhoun, D; Donovan, D; Echo-Hawk, A; Hirchak, K; Leickly, E; McDonell, MG; Nepom, JR; Ries, R; Roll, J; Schwartz, SM; Suchy-Dicey, A, 2016) |
| "Two patients with a diagnosis of alcohol use disorder were treated with nalmefene." | ( Martelli, A; Mattioli, F; Milano, G; Natta, WM; Zavan, V, 2016) |
| "The treatment of alcohol use disorder still remains a challenge." | ( Addolorato, G; Bernardi, M; Caputo, F; D'Amore, A; Domenicali, M; Maremmani, AG; Maremmani, I; Zoli, G, 2016) |
| "The treatment of alcohol use disorder (AUD) with sodium oxybate (SMO) or gamma-hydroxybutyric acid (GHB) was introduced in Italy and Austria more than 20 years and 15 years ago, respectively, and it is now widely employed to treat alcohol withdrawal syndrome (AWS) and to maintain alcohol abstinence." | ( Addolorato, G; Bernardi, M; Caputo, F; Domenicali, M; Tarli, C; Vignoli, T; Zoli, G, 2016) |
| "Current pharmacological treatments for alcohol dependence have focused on reducing alcohol consumption, but to date there are few treatments that also address the negative affective symptoms during acute and protracted alcohol withdrawal which are often exacerbated in people with comorbid anxiety and depression." | ( Kash, TL; Lowery-Gionta, EG; Marcinkiewcz, CA, 2016) |
| "Forty-one participants with DSM-IV alcohol dependence who also met syndromal criteria for anxiety disorder with or without co-occurring major depressive syndrome initiated treatment with lorazepam (starting dose 0." | ( Bhatt, S; Bogenschutz, MP; Bohan, J; Foster, B; Romo, P; Tonigan, JS; Wilcox, CE, 2016) |
| "The effective management of alcohol use disorder entails psychosocial or pharmacological treatments or a combination of both." | ( Freyer, CH; Haber, PS; Morley, KC, 2016) |
| "Club drugs and alcohol abuse are prevalent among methadone maintenance treatment (MMT) patients." | ( Andrew, B; Gu, J; Hao, C; Hao, Y; Jiao, M; Liu, D; Xu, H; Zhang, X; Zhao, Y, 2017) |
| "The original approach to treat alcohol use disorder, by altering ethanol pharmacokinetics has been much less investigated." | ( Akhlaghi, F; Haass-Koffler, CL; Leggio, L; Swift, RM, 2017) |
| "One hundred and one patients with alcohol dependence (AD) attending the Drug De-addiction and Treatment Centre and 50 healthy controls were evaluated in this cross-sectional study." | ( Grover, S; Mattoo, SK; Pendharkar, S, 2016) |
| "Pharmacotherapy for alcohol dependence has been shown to be moderately efficacious with few safety concerns, but it is substantially underutilised." | ( Goh, ET; Morgan, MY, 2017) |
| "To evaluate drug therapy for alcohol dependence in the 12 months after first diagnosis in UK primary care." | ( Ashcroft, DM; Owens, L; Pirmohamed, M; Thompson, A; van Staa, TP, 2017) |
| "Our data show that treatment for alcohol dependence is haphazard, and there is an urgent need to explore strategies for improving clinical management of this patient group." | ( Ashcroft, DM; Owens, L; Pirmohamed, M; Thompson, A; van Staa, TP, 2017) |
| "Among US military veterans, alcohol use disorder (AUD) is prevalent and in severe cases patients need intensive AUD treatment beyond outpatient care." | ( Bowe, TR; Burden, JL; Ellerbe, LS; Finlay, AK; Gupta, S; Harris, AHS; Rubinsky, AD; Timko, C; Wong, JJ, 2017) |
| "Patients (n = 3589) with alcohol dependence receiving treatment in an alcohol clinical trial were primarily male (73." | ( Hallgren, KA; Heather, N; Kirouac, M; Maisto, SA; Montes, KS; Pearson, MR; Roos, CR; Wilson, AD; Witkiewitz, K, 2017) |
| "Two hundred two patients with alcohol dependence, who received baclofen treatment for drinking reduction, were followed up for 1 year." | ( Auffret, M; Bordet, R; Cottencin, O; Deheul, S; Duhamel, A; Gautier, S; Labreuche, J; Pignon, B; Rolland, B; Simioni, N, 2017) |
| "Precision medicine for alcohol use disorder (AUD) allows optimal treatment of the right patient with the right drug at the right time." | ( Biernacka, JM; Choi, DS; Geske, JR; Hinton, DJ; Hitschfeld, MJ; Ho, AMC; Karpyak, VM; Vázquez, MS, 2017) |
| "The average duration of alcohol dependence was less than a decade before seeking treatment." | ( Chand, PK; Malik, K; Marimuthu, P; Suman, LN, 2017) |
| "Abstinence-based approaches to treating alcohol use disorder (AUD) are highly prevalent, but abstinence from chronic drinking may exacerbate subsequent levels of alcohol intake in relapse." | ( Allen, DC; Gonzales, SW; Grant, KA, 2018) |
| "Approved pharmacological treatments for alcohol use disorder are limited in their effectiveness, and new drugs that can easily be translated into the clinic are warranted." | ( Bühler, S; Ciccocioppo, R; Domi, E; Froemke, RC; Grinevich, V; Hansson, AC; Kiefer, F; Kiessling, E; Koopmann, A; Sommer, WH; Spanagel, R; Uhrig, S; Vollstädt-Klein, S, 2018) |
| "Given that alcohol use disorder is so often associated with early traumatic experiences, the author is proposing in a current on-going UK-based study that patients with alcohol use disorder who have undergone a medical detoxification from alcohol might benefit from a course of MDMA-assisted psychotherapy." | ( Sessa, B, 2018) |
| "To investigate if treatment for alcohol dependence in primary care is as effective as specialist addiction care." | ( Andreasson, S; Hammarberg, A; Wallhed Finn, S, 2018) |
| "Treatment for alcohol dependence in primary care is a promising approach, especially for individuals with low to moderate dependence." | ( Andreasson, S; Hammarberg, A; Wallhed Finn, S, 2018) |
| "Individuals with alcohol use disorder (AUD) do not always respond to currently available treatments, and evaluation of new candidate pharmacotherapies is indicated." | ( Baker, NL; Book, GA; Gray, KM; McClure, EA; Squeglia, LM; Tomko, RL, 2018) |
| "As a treatment for alcohol use disorders, baclofen is associated with higher rates of abstinence than placebo." | ( Jones, A; Rose, AK, 2018) |
| "Because BD-II and alcohol dependence are neurodegenerative disorders, agents with anti-inflammatory and neurotrophic effects might provide effective therapy." | ( Chang, YH; Chen, KC; Chen, PS; Chen, SL; Hong, JS; Huang, SY; Lee, IH; Lee, SY; Lu, RB; Tzeng, NS; Wang, LJ; Wang, TY; Yang, YK, 2018) |
| "BD-II comorbid with alcohol dependence might benefit from add-on memantine treatment, which significantly reduced clinical severity, alcohol use, and plasma cytokine levels, and increased BDNF levels." | ( Chang, YH; Chen, KC; Chen, PS; Chen, SL; Hong, JS; Huang, SY; Lee, IH; Lee, SY; Lu, RB; Tzeng, NS; Wang, LJ; Wang, TY; Yang, YK, 2018) |
| "A CM intervention for alcohol use disorders should be in alignment with existing cultural and community practices such as alcohol abstinence, is more likely to be successful when Elders and community leaders are champions of the intervention, the intervention is compatible with counseling or treatment methodologies, and the intervention provides rewards that are both culturally specific and practical." | ( Avey, JP; Buchwald, D; Dirks, LG; Donovan, D; Herron, J; Hirchak, KA; Leickly, E; McDonell, MG; McPherson, S; Nepom, J; Shaw, J; Skalisky, J, 2018) |
| "Drug misuse is associated with worse alcohol use disorder (AUD) treatment outcomes, yet no studies have investigated the role of opioid misuse in AUD treatment outcomes." | ( Kranzler, HR; Votaw, VR; Vowles, KE; Witkiewitz, K, 2018) |
| "During acute withdrawal, following alcohol dependence induction, there was an upregulation in Oprk1 mRNA expression in alcohol self-administering animals, but not non-alcohol self-administering animals, that confirmed dysregulation of the KOR/DYN system within the BNST." | ( Erikson, CM; Walker, BM; Wei, G, 2018) |
| "Current treatments for alcohol use disorders have limited efficacy and there is a high degree of variability in treatment response." | ( Baillie, A; Haber, PS; Kranzler, HR; Luquin, N; Morley, KC; Shanahan, M; Teesson, M; Trent, R, 2018) |
| "Adherence to medications for treating alcohol use disorder (AUD) is poor." | ( Dermody, SS; Hendershot, CS; Stoner, SA; Wardell, JD, 2018) |
| "Pharmacological treatments for alcohol use disorder show a modest effect, and they are unavailable in certain countries." | ( Chompookham, P; Kalayasiri, R; Nilaban, S; Rukngan, W; Suwanmajo, S; Yoosom, P, 2018) |
| "Treatment-seeking men with alcohol use disorder (AUD) classically exhibit a blunted hypothalamic-pituitary-adrenal (HPA) axis response to pharmacologic and behavioral provocations during the early phases of abstinence from alcohol." | ( Adinoff, B; Frazier, IR; Javors, MA; Lewis, B; Nixon, SJ; Price, JL; Walker, R, 2019) |
| "Patients with alcohol dependence treated in primary care with nalmefene, taken as needed, in conjunction with simple psychosocial support, significantly reduced their alcohol consumption." | ( Brix Schou, M; Brotons, C; Castera, P; Großkopf, J; Meulien, D; Steiniger Brach, B; Stewart, E; Zhang, D, 2018) |
| "We examined if NMR changes during alcohol use disorder (AUD) treatment and how changes in NMR relate to reductions in drinking." | ( Andrade, AK; Dermody, SS; Hendershot, CS; Novalen, M; Tyndale, RF, 2020) |
| "Three weeks of alcohol use disorder treatment among daily smokers coincided with a significant reduction in both alcohol use and NMR for men; however, neither drinking level nor NMR changed for women." | ( Andrade, AK; Dermody, SS; Hendershot, CS; Novalen, M; Tyndale, RF, 2020) |
| "Tobacco use and alcohol abuse are associated with higher risk of tuberculosis (TB) infection, progression to active TB and adverse treatment outcomes among patients with TB." | ( Anand, T; Isaakidis, P; Jeyashree, K; Madhukeshwar, AK; Navya, N; Nayarmoole, BM; Nirgude, AS, 2019) |
| "Effective medications for treating alcohol use disorders (AUD) are available but underutilized." | ( Harris, AHS; Matson, TE; Williams, EC, 2019) |
| "Outcomes of alcohol use disorder management are improved with evidence-based psychosocial therapy, but there is no support for preferring one specific evidence-based therapy over another." | ( Warren, D, 2019) |
| "Ethanol administration induced alcohol dependence behaviors, with more time spent in the ethanol-paired compartment." | ( Li, C; Li, Q; Lu, G; Ma, H; Sun, H; Sun, L; Wang, L; Wang, M; Wang, Y; Zhang, X; Zhou, J, 2019) |
| "Alcohol relapse is a treatment goal for alcohol dependence and the target for medications' development." | ( Kreek, MJ; Zhou, Y, 2019) |
| "Despite the increasing burden of alcohol dependence, treatment resources in low- and middle-income countries such as India are concentrated in poorly accessible tertiary care facilities." | ( Bhatia, U; D'souza, E; Fernandes, G; Murthy, P; Nadkarni, A; Velleman, R, 2020) |
| "Because alcohol use disorders (AUDs) in patients living with HIV/AIDS are associated with a reduction in therapeutic outcomes and increases the risk of morbidity/mortality, finding an appropriate pharmacotherapy treatment for this disorder is necessary." | ( Farhadian, M; Farhadian, N; Farnia, V; Moradi, S; Rezaeian, S; Shahlaei, M; Zamanian, MH, 2020) |
| "The efficacy of naltrexone to treat alcohol use disorder (AUD) is modest." | ( de Laat, B; Froehlich, JC; Huang, Y; Krishnan-Sarin, S; Morris, ED; Nabulsi, N; O'Malley, SS, 2021) |
| "The comorbidity between alcohol use disorder and post-traumatic stress disorder represents a serious health care burden with few effective treatment options." | ( Becker, HC; Carper, BA; Lopez, MF; Nolen, TL; Reasons, SE; Williams, RL, 2020) |
| "Medication is integral in treating alcohol use disorder." | ( Hong, TK; Huh, SY; Kim, SG, 2020) |
| "Participants had a current diagnosis of alcohol dependence, high trait anxiety score, and were not seeking treatment for alcohol dependence or anxiety." | ( Battista, JT; Deschaine, SL; Farokhnia, M; Lee, MR; Leggio, L; Li, X; Portelli, J; Ron, D, 2020) |
| "Surgical treatment of patients with alcohol use disorder can lead to disturbances (withdrawal syndrome, delirium) which require intensive care treatment." | ( Facklam, J; Schumacher, D; Stuppe, M, 2020) |
| "To compare nontreatment seekers with alcohol dependence (AD) from 4 human laboratory studies conducted at Brown University (N = 240; 65." | ( Haass-Koffler, CL; Kenna, GA; Lee, MR; Leggio, L; Li, X; Long, VM; Piacentino, D; Swift, RM, 2020) |
| "Alcohol craving is a key symptom of alcohol use disorder (AUD) and a significant cause of poor treatment outcome and frequent relapse." | ( Odenwald, M; Rockstroh, B; Sehrig, S, 2021) |
| "Pharmacotherapy for Alcohol Dependence (AD) is underutilized." | ( Agabio, R; Balia, S; Gessa, GL; Pani, PP, 2021) |
| "Pharmacotherapy for alcohol use disorder (AUD) is recommendable, but under-used, possibly due to deficient knowledge of medications." | ( Heikkinen, M; Lähteenvuo, M; Mittendorfer-Rutz, E; Taipale, H; Tanskanen, A; Tiihonen, J, 2021) |
| "The 2018 guideline for the treatment of alcohol dependence in Japan recommends abstinence as the primary goal, but reduction of alcohol consumption is described as an appropriate treatment goal in some patients." | ( Tamaki, K, 2021) |
| "Harmful alcohol use and alcohol use disorders (AUD) result in major health and community burden worldwide, yet treatment options are limited." | ( Haber, PS; Logge, WB; Morley, KC, 2022) |
| "Pharmacological treatment in alcohol use disorder suffers from modest effect sizes." | ( Bach, P; Hermann, D; Hoffmann, S; Kiefer, F; Mann, K; Pompili, E; Sommer, WH; Vollstädt-Klein, S; Weil, G, 2021) |
| "The treatment gap for alcohol use disorders (AUD) in India is the highest among all mental health and substance use disorders." | ( Catalano, A; Chaudhuri, N; Costa, S; D'Souza, E; Fernandes, D; Gupta, D; Heath, A; Houde, A; Hussain, F; Nadkarni, A; Pednekar, S; Sambari, S; Velleman, R, 2021) |
| "Further, alcohol dependence was associated with decreased likelihood of treatment with buprenorphine (AOR 0." | ( Bierut, LJ; Grucza, RA; Hartz, SM; Mintz, CM; Presnall, NJ; Sahrmann, JM; Xu, KY, 2021) |
| "Identification of alcohol use disorder, a brief intervention, and initiation of naltrexone resulted in a 15% follow-up rate in formal addiction treatment." | ( Anderson, ES; Chamberlin, M; D'Onofrio, G; Hawk, K; Herring, AA; McCormack, R; Ullal, M; Zuluaga, M, 2021) |
| "Because alcohol use disorder (AUD) is heterogeneous, research aimed at characterizing features associated with treatment response could advance personalized pharmacotherapy." | ( Donato, S; Green, R; Ray, LA, 2021) |
| "Pharmacotherapy for alcohol use disorders (AUD) is effective." | ( Danielsson, AK; Lundin, A; Sjöqvist, H; Wallhed Finn, S, 2021) |
| "Because XR-NTX reduces drinking in alcohol use disorder (AUD), we conducted a secondary analysis of the X:BOT sample of patients successfully inducted onto treatment to determine whether XR-NTX (n = 204) was superior to BUP-NX (n = 270) in reducing drinking or heavy drinking in patients with OUD." | ( Campbell, A; Choo, TH; Kermack, AS; Nunes, EV; Pavlicova, M; Peavy, M; Roache, JD; Rotrosen, J, 2021) |
| "In Study 1, patients with Alcohol Use Disorder (AUD) (N = 45) with varying AW levels at treatment entry were assessed to examine AW effects on corticostriatal responses to stress, alcohol cue and neutral visual images with functional magnetic resonance imaging (fMRI)." | ( Angarita, G; Fogelman, N; Hermes, G; Seo, D; Sinha, R; Wemm, S, 2022) |
| "We recommend vigorous screening for alcohol use disorder in liver disease patients, followed by psychosocial intervention and complemented by pharmaceutical therapy." | ( Askgaard, G; Nielsen, AS; Thiele, M, 2022) |
| "Stigma towards alcohol use disorders is prevalent in India and can lead to social exclusion and hamper treatment access and outcomes." | ( Kumar, S; Nadkarni, A; Schess, J; Velleman, R, 2022) |
| "Anxiety, depression, and co-morbid alcohol use disorder (AUD) are frequent and often difficult to diagnose and treat accurately." | ( Andersen, K; Nielsen, B, 2022) |
| "Although alcohol dependence (AD) is highly prevalent, only few medications are approved for its treatment." | ( Bach, P; Kiefer, F; Klose, C; Koopmann, A; Krisam, J; Lenz, B; Limprecht, R; Pourbaix, M; Ries, M; Stenger, M; Thomas, BC; Vollstaedt-Klein, S; Zimmermann, S, 2022) |
| "Data from trials of medications for alcohol use disorder (AUD) can be used to identify predictors of drinking outcomes regardless of treatment, which can inform the design of future trials with heterogeneous populations." | ( Gueorguieva, R; O'Malley, SS; Phan, H; Wallach, JD; Witkiewitz, K; Wu, R, 2022) |
| "While alcohol use disorder (AUD) is a well-established risk factor for intimate partner aggression (IPA), effective treatments for co-occurring AUD and IPA (AUD/IPA) are lacking." | ( Back, SE; Brower, J; Flanagan, JC; Hogan, JN; Jarnecke, AM; Kirby, C; Massa, AA; Nietert, PJ; Parrott, D; Sippel, L, 2022) |
| "PKD mediates effect of alcohol abuse on pathological process of pancreatitis and constitutes a novel therapeutic target to treat this disease." | ( Chheda, C; Elmadbouh, O; Pandol, SJ; Tan, G; Yuan, J, 2022) |
| "We enrolled 120 patients with alcohol use disorder who were randomly assigned to either treatment with vigabatrin (2g/day for 4 days) or placebo." | ( Bonomo, Y; Collins, L; Lloyd-Jones, M; Norman, A; O'Neill, H; Ogden, E; Pastor, A; Williams, J, 2023) |
| "In the full model, alcohol use disorder (AUD), past-year PER visits, and treatment modality (telephone visits) continued to be significantly associated with COVID-19 PER use, while past-year PER visits correlated with Re-entry PER use." | ( DeViva, J; Farook, M; Gross, G; Levina, V; Meshberg-Cohen, S, 2023) |
| "Craving alcohol is a core symptom of alcohol use disorder (AUD) and an important target for treatment." | ( Gehlenborg, J; Göritz, AS; Kühn, S; Moritz, S, 2023) |
| "Craving alcohol is a core symptom of alcohol use disorder (AUD) and an important target for treatment." | ( Gehlenborg, J; Göritz, AS; Kühn, S; Moritz, S, 2023) |
| "IDENTIFYING AND TREATING ALCOHOL USE DISORDERS IN THE ELDERLY Aging does not prevent the occurrence of alcohol use disorders, the frequency of which declines little with age." | ( Broyer, P; Menecier, P, 2022) |
| "IDENTIFYING AND TREATING ALCOHOL USE DISORDERS IN THE ELDERLY Aging does not prevent the occurrence of alcohol use disorders, the frequency of which declines little with age." | ( Broyer, P; Menecier, P, 2022) |
| "Treatment options for alcohol use disorders (AUDs) have minimally advanced since 2004, while the annual deaths and economic toll have increased alarmingly." | ( Aziz, HC; Becker, HC; Beneze, A; Bess, J; Crabbe, JC; Eisenstein, TK; Firsick, EJ; Grigsby, KB; Light, JM; Lopez, MF; Mangieri, RA; Mason, BJ; Meissler, JJ; Metten, P; Miller, J; Morrisett, RA; Ozburn, AR; Quello, S; Roberto, M; Roberts, AJ; Shadan, F; Skinner, M; Townsley, KG, 2023) |
| "Treatment resistance in alcohol use disorders (AUD) is a major problem for affected individuals and for society." | ( Bach, P; Baldermann, JC; Bogerts, B; Jakobs, M; Kiening, K; Kuhn, J; Luderer, M; Lux, A; Mann, K; Müller, UJ; Visser-Vandewalle, V; Voges, J, 2023) |
| "No single effective therapy for alcohol abuse has been found, despite it being a serious sociological and economic problem for hundreds of years." | ( Gorczyca, P; Piegza, M; Pudlo, R; Stokłosa, I; Stokłosa, M; Więckiewicz, G, 2023) |
| "To address this aspect of alcohol use disorder, 102 active-duty soldiers participating in command-mandated Army outpatient alcohol treatment were randomized to also receive the brain-penetrant alpha-1 adrenergic receptor antagonist prazosin or placebo for 13 weeks." | ( Crews, L; Daniels, C; Darnell, J; Goke, K; Hart, K; Hendrickson, R; Holmes, H; Mayer, C; Peskind, ER; Poupore, EL; Raskind, MA; Rasmussen, D; Saxon, A; Simpson, T; Terry, G; Thomas, RG; Williams, T, 2023) |
| "Current treatments for adolescent alcohol use disorder (AUD) are mainly psychosocial and limited in their efficacy." | ( Brady, KT; Browning, BD; Ferguson, PL; Gray, KM; Green, R; Kirkland, AE; Liu, H; Maralit, AM; Meyerhoff, DJ; Miranda, R; Prisciandaro, JJ; Squeglia, LM; Tomko, RL, 2023) |
| "The overall prevalence of alcohol use disorders and drug use disorders in adolescents has been declining in recent years, yet little is known about treatment use for these disorders among adolescents." | ( Goodwin, RD; Lu, W; Muñoz-Laboy, M; Sohler, N; Xu, L, 2023) |
| "Although varenicline has been used for alcohol dependence (AD) treatment, its efficacy for this condition remains controversial." | ( Paitoon, P; Phimarn, W; Sakhancord, R; Saramunee, K; Sungthong, B, 2023) |
| "In order to evaluate alcohol abuse as a possible trigger for CD and its effect on PKS activation, naïve mice were administered (oral-gavage) with ethanol for 10 consecutive days." | ( Amodeo, G; Franchi, S; Galimberti, G; Sacerdote, P, 2023) |
| "Medium-term inpatient treatment of alcohol addiction leads to one year of abstinence in 34% to 76% of patients." | ( Beniš, M; Miovský, M; Popov, P; Skorkovský, T; Vevera, J, 2023) |