An EC 4.3.1.* (ammonia-lyase) inhibitor that interferes with the action of serine-sulfate ammonia-lyase (EC 4.3.1.10).
ChEBI ID: 77090
| Member | Definition | Class |
|---|---|---|
| hydrazine | hydrazine | |
| hydroxylamine | The simplest hydroxylamine, consisting of ammonia bearing a hydroxy substituent. It is an intermediate in the biological nitrification by microbes like bacteria. | hydroxylamine |
| plasmenylserine | The L-enantiomer of O-phosphoserine. | O-phospho-L-serine |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 5,463 (41.82) | 18.7374 |
| 1990's | 1,490 (11.41) | 18.2507 |
| 2000's | 2,285 (17.49) | 29.6817 |
| 2010's | 2,849 (21.81) | 24.3611 |
| 2020's | 975 (7.46) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 333 (2.42%) | 5.53% |
| Reviews | 506 (3.67%) | 6.00% |
| Case Studies | 241 (1.75%) | 4.05% |
| Observational | 17 (0.12%) | 0.25% |
| Other | 12,686 (92.04%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 3.5481 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 26.8325 | 2 | 2 |
| arylsulfatase A | Homo sapiens (human) | Potency | 37.9330 | 1 | 1 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 29.0810 | 1 | 1 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 0.0120 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 0.0028 | 2 | 2 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 5.0119 | 1 | 1 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 39.7164 | 1 | 1 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 70.7946 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 0.0060 | 1 | 1 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 0.7943 | 2 | 2 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 0.4253 | 1 | 1 |
| endonuclease IV | Escherichia coli | Potency | 10.0000 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 33.4915 | 1 | 1 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 26.6032 | 1 | 1 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 0.7943 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 0.7943 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 0.7943 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 0.7943 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 0.7943 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 0.7943 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 0.7943 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 0.7943 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 0.7943 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 0.7943 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 0.7943 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 0.7943 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 0.7943 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 0.7943 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 0.7943 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 0.7943 | 1 | 1 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 0.0282 | 1 | 1 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 15.8489 | 2 | 2 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 39.8107 | 1 | 1 |
| Single-stranded DNA cytosine deaminase | Homo sapiens (human) | Potency | 49.2215 | 2 | 4 |
| TDP1 protein | Homo sapiens (human) | Potency | 18.9624 | 2 | 2 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 0.5302 | 1 | 3 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 420.0000 | 1 | 1 |
| Carbonic anhydrase 4 | Homo sapiens (human) | Ki | 4,260.0000 | 1 | 1 |
| Carbonic anhydrase 5A, mitochondrial | Homo sapiens (human) | Ki | 360.0000 | 1 | 1 |
| Carbonic anhydrase 9 | Homo sapiens (human) | Ki | 920.0000 | 1 | 1 |
| Glutamate carboxypeptidase 2 | Homo sapiens (human) | IC50 | 523.0000 | 2 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Metabotropic glutamate receptor 4 | Homo sapiens (human) | EC50 | 1.1500 | 2 | 2 |
| Metabotropic glutamate receptor 4 | Rattus norvegicus (Norway rat) | EC50 | 52.0000 | 2 | 2 |
| Metabotropic glutamate receptor 6 | Rattus norvegicus (Norway rat) | EC50 | 2.7000 | 1 | 1 |
| Metabotropic glutamate receptor 7 | Homo sapiens (human) | EC50 | 200.0000 | 1 | 1 |
| Metabotropic glutamate receptor 7 | Rattus norvegicus (Norway rat) | EC50 | 160.0000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Carbonic anhydrase 1 | Homo sapiens (human) | KA | 100.0000 | 1 | 1 |