Any substance which blocks the painful sensation of heat caused by capsaicin acting on the TRPV1 ion channel.
| Member | Definition | Class |
|---|
| arachidonoylserotonin | An N-acylserotonin obtained by formal condensation of the carboxy group of arachidonic acid with the primary amino group of serotonin. | N-arachidonoylserotonin |
| capsazepine | A benzazepine that is 2,3,4,5-tetrahydro-1H-2-benzazepine which is substituted by hydroxy groups at positions 7 and 8 and on the nitrogen atom by a 2-(p-chlorophenyl)ethylaminothiocarbonyl group. A synthetic analogue of capsaicin, it was the first reported capsaicin receptor antagonist. | capsazepine |
| tramadol | A 2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol in which both stereocentres have R-configuration; the (R,R)-enantiomer of the racemic opioid analgesic tramadol, it exhibits ten-fold higher analgesic potency than the (S,S)-enantiomer. | (R,R)-tramadol |
| tramadol hydrochloride | A hydrochloride resulting from the reaction of (R,R)-tramadol with 1 molar equivalent of hydrogen chloride; the (R,R)-enantiomer of the racemic opioid analgesic tramadol hydrochloride, it exhibits ten-fold higher analgesic potency than the (S,S)-enantiomer. | (R,R)-tramadol hydrochloride |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 19.6222 | 1 | 2 |
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 2.5119 | 1 | 1 |
| 67.9K protein | Vaccinia virus | Potency | 37.6188 | 2 | 2 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 17.2168 | 1 | 3 |
| arylsulfatase A | Homo sapiens (human) | Potency | 0.0054 | 1 | 1 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 26.6086 | 2 | 2 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 8.8317 | 2 | 3 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 19.9526 | 2 | 2 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 33.9972 | 1 | 2 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 8.9125 | 1 | 1 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 28.1838 | 1 | 1 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 6.0216 | 2 | 3 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 25.0594 | 1 | 1 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 6.0216 | 2 | 3 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 47.3936 | 2 | 2 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 2.6640 | 1 | 2 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 6.9906 | 1 | 2 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 1.7377 | 1 | 1 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 22.1060 | 1 | 2 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 3.1623 | 2 | 2 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 1.1132 | 2 | 2 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| endonuclease IV | Escherichia coli | Potency | 25.1189 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 15.0890 | 1 | 1 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 19.6830 | 3 | 3 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 8.8517 | 2 | 4 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 141.2540 | 1 | 1 |
| G | Vesicular stomatitis virus | Potency | 1.7377 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 4.5141 | 3 | 3 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 6.3096 | 1 | 1 |
| GLS protein | Homo sapiens (human) | Potency | 18.8600 | 2 | 2 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 10.6822 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 8.3902 | 2 | 8 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 1.7377 | 1 | 1 |
| hypothetical protein, conserved | Trypanosoma brucei | Potency | 24.4702 | 2 | 2 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 5.0119 | 2 | 2 |
| IDH1 | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 1.7377 | 1 | 2 |
| Interferon beta | Homo sapiens (human) | Potency | 1.7377 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 9.1498 | 2 | 2 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 14.2191 | 1 | 2 |
| lethal(3)malignant brain tumor-like protein 1 isoform I | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 12.7503 | 1 | 3 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 3.9811 | 2 | 2 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 28.1838 | 1 | 1 |
| Parkin | Homo sapiens (human) | Potency | 20.5962 | 1 | 1 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 33.4889 | 1 | 1 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 50.4512 | 1 | 2 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 0.8913 | 1 | 1 |
| polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 16.8336 | 1 | 1 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 5.6234 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 7.3644 | 2 | 7 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 66.8968 | 1 | 2 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 51.0514 | 2 | 4 |
| Thrombopoietin | Homo sapiens (human) | Potency | 10.0000 | 2 | 2 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 25.7877 | 2 | 4 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 0.8913 | 1 | 1 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 0.8913 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |