A neurotransmitter transporter modulator that activates glutamate transporters.
ChEBI ID: 64370
| Member | Definition | Class |
|---|---|---|
| carbamazepine | A dibenzoazepine that is 5H-dibenzo[b,f]azepine carrying a carbamoyl substituent at the azepine nitrogen, used as an anticonvulsant. | carbamazepine |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 2,756 (25.05) | 18.7374 |
| 1990's | 2,297 (20.87) | 18.2507 |
| 2000's | 2,556 (23.23) | 29.6817 |
| 2010's | 2,642 (24.01) | 24.3611 |
| 2020's | 753 (6.84) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 1,128 (9.41%) | 5.53% |
| Reviews | 1,217 (10.15%) | 6.00% |
| Case Studies | 2,747 (22.91%) | 4.05% |
| Observational | 45 (0.38%) | 0.25% |
| Other | 6,855 (57.16%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| acetylcholinesterase | Homo sapiens (human) | Potency | 35.4002 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 5.4728 | 6 | 6 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 0.3548 | 1 | 1 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 6.3096 | 1 | 1 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 3.7578 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 4.3639 | 2 | 2 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 51.4518 | 3 | 3 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 0.0224 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 1.4488 | 2 | 3 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 12.0053 | 4 | 4 |
| IDH1 | Homo sapiens (human) | Potency | 1.0323 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 0.0040 | 1 | 1 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 0.1000 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 32.6427 | 1 | 1 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 44.8436 | 2 | 2 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 0.2371 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 30.4821 | 1 | 2 |
| TDP1 protein | Homo sapiens (human) | Potency | 29.0929 | 1 | 1 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 0.4467 | 1 | 1 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 6.3096 | 2 | 2 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| Vpr | Human immunodeficiency virus 1 | Potency | 0.8913 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 711.0000 | 3 | 3 |
| Bile salt export pump | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Cytochrome P450 2J2 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| P2X purinoceptor 4 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | IC50 | 104.7130 | 1 | 1 |
| Sodium channel protein type 1 subunit alpha | Rattus norvegicus (Norway rat) | IC50 | 167.0000 | 1 | 2 |
| Sodium channel protein type 2 subunit alpha | Rattus norvegicus (Norway rat) | IC50 | 167.0000 | 1 | 2 |
| Sodium channel protein type 3 subunit alpha | Rattus norvegicus (Norway rat) | IC50 | 167.0000 | 1 | 2 |
| Sodium channel protein type 4 subunit alpha | Homo sapiens (human) | Ki | 52.0000 | 1 | 1 |
| Sodium channel protein type 9 subunit alpha | Homo sapiens (human) | IC50 | 22.0000 | 1 | 1 |
| Sodium channel protein type 9 subunit alpha | Homo sapiens (human) | Ki | 32.7000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Albumin | Rattus norvegicus (Norway rat) | Kd | 103.0000 | 1 | 1 |
| Cytochrome P450 2B6 | Homo sapiens (human) | EC50 | 145.0000 | 1 | 1 |
| Frizzled-8 | Mus musculus (house mouse) | Kd | 16.8000 | 1 | 1 |
| Major prion protein | Homo sapiens (human) | EC50 | 10.0000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Sodium channel protein type 4 subunit alpha | Homo sapiens (human) | Kr | 720.0000 | 1 | 1 |
| UDP-glucuronosyltransferase 2B7 | Homo sapiens (human) | Km | 214.0000 | 1 | 1 |