EC 5.3.3.5 (cholestenol Delta-isomerase) inhibitor

An EC 5.3.3.* (intramolecular oxidase transposing C=C bonds) inhibitor that interferes with the action of a cholestenol Delta-isomerase (EC 5.3.3.5).

ChEBI ID: 86385

Members (4)

Member	Definition	Class
cupric chloride	An inorganic chloride of copper in which the metal is in the +2 oxidation state.	copper(II) chloride
loceryl	A member of the class of morpholines that is cis-2,6-dimethylmorpholine in which the hydrogen attached to the nitrogen is replaced by a racemic 2-methyl-3-[p-(2-methylbutan-2-yl)phenyl]propyl group. An inhibitor of the action of squalene monooxygenase, Delta(14) reductase and D7-D8 isomerase and an antifungal agent, it is used (generally as its hydrochloride salt) for the topical treatment of fungal nail and skin infections.	amorolfine
trifluoperazine	A member of the class of phenothiazines that is phenothiazine having a trifluoromethyl subsitituent at the 2-position and a 3-(4-methylpiperazin-1-yl)propyl group at the N-10 position.	trifluoperazine
zinc chloride	A compound of zinc and chloride ions in the ratio 1:2. It exists in four crystalline forms, in each of which the Zn(2+) ions are trigonal planar coordinated to four chloride ions.	zinc dichloride

Research

Studies (5,669)

Timeframe	Studies, Drugs with This Role(%)	All Drugs %
pre-1990	2,556 (45.09)	18.7374
1990's	1,117 (19.70)	18.2507
2000's	927 (16.35)	29.6817
2010's	933 (16.46)	24.3611
2020's	136 (2.40)	2.80

Study Types

Publication Type	Studies, Drugs with this Role (%)	All Drugs (%)
Trials	241 (3.97%)	5.53%
Reviews	118 (1.94%)	6.00%
Case Studies	240 (3.96%)	4.05%
Observational	1 (0.02%)	0.25%
Other	5,468 (90.11%)	84.16%

Protein Targets (140)

Potency Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
15-lipoxygenase, partial	Homo sapiens (human)	Potency	19.9526	1	1
67.9K protein	Vaccinia virus	Potency	15.9109	2	3
activating transcription factor 6	Homo sapiens (human)	Potency	23.9145	1	1
aldehyde dehydrogenase 1 family, member A1	Homo sapiens (human)	Potency	39.8107	1	1
apical membrane antigen 1, AMA1	Plasmodium falciparum 3D7	Potency	11.2202	1	1
AR protein	Homo sapiens (human)	Potency	27.3441	5	5
aryl hydrocarbon receptor	Homo sapiens (human)	Potency	29.8493	1	1
ATAD5 protein, partial	Homo sapiens (human)	Potency	17.7649	2	3
Ataxin-2	Homo sapiens (human)	Potency	17.7828	1	1
atrial natriuretic peptide receptor 2 precursor	Homo sapiens (human)	Potency	16.4816	1	1
Cellular tumor antigen p53	Homo sapiens (human)	Potency	29.8493	1	1
cellular tumor antigen p53 isoform a	Homo sapiens (human)	Potency	17.9008	2	2
Chain A, HADH2 protein	Homo sapiens (human)	Potency	0.1995	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	Homo sapiens (human)	Potency	15.8489	1	1
Chain B, HADH2 protein	Homo sapiens (human)	Potency	0.1995	1	1
chromobox protein homolog 1	Homo sapiens (human)	Potency	55.5278	2	2
cytochrome P450 2C19 precursor	Homo sapiens (human)	Potency	7.5093	1	3
cytochrome P450 2C9, partial	Homo sapiens (human)	Potency	24.5454	1	1
cytochrome P450 2D6	Homo sapiens (human)	Potency	4.8975	1	1
cytochrome P450 2D6 isoform 1	Homo sapiens (human)	Potency	1.1038	1	3
cytochrome P450 3A4 isoform 1	Homo sapiens (human)	Potency	13.5093	2	5
cytochrome P450 family 3 subfamily A polypeptide 4	Homo sapiens (human)	Potency	15.4871	1	1
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	Homo sapiens (human)	Potency	33.4915	1	1
D(1A) dopamine receptor	Homo sapiens (human)	Potency	0.5106	2	2
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	Homo sapiens (human)	Potency	22.3872	1	1
DNA polymerase kappa isoform 1	Homo sapiens (human)	Potency	18.8876	1	1
estrogen nuclear receptor alpha	Homo sapiens (human)	Potency	29.2153	6	6
estrogen-related nuclear receptor alpha	Homo sapiens (human)	Potency	25.7565	3	3
euchromatic histone-lysine N-methyltransferase 2	Homo sapiens (human)	Potency	17.9162	1	3
EWS/FLI fusion protein	Homo sapiens (human)	Potency	14.8210	4	4
Fumarate hydratase	Homo sapiens (human)	Potency	23.4850	1	1
G	Vesicular stomatitis virus	Potency	24.5454	1	1
GABA theta subunit	Rattus norvegicus (Norway rat)	Potency	13.8993	1	3
Gamma-aminobutyric acid receptor subunit alpha-1	Rattus norvegicus (Norway rat)	Potency	13.8993	1	3
Gamma-aminobutyric acid receptor subunit alpha-2	Rattus norvegicus (Norway rat)	Potency	13.8993	1	3
Gamma-aminobutyric acid receptor subunit alpha-3	Rattus norvegicus (Norway rat)	Potency	13.8993	1	3
Gamma-aminobutyric acid receptor subunit alpha-4	Rattus norvegicus (Norway rat)	Potency	13.8993	1	3
Gamma-aminobutyric acid receptor subunit alpha-5	Rattus norvegicus (Norway rat)	Potency	13.8993	1	3
Gamma-aminobutyric acid receptor subunit alpha-6	Rattus norvegicus (Norway rat)	Potency	13.8993	1	3
Gamma-aminobutyric acid receptor subunit beta-1	Rattus norvegicus (Norway rat)	Potency	13.8993	1	3
Gamma-aminobutyric acid receptor subunit beta-2	Rattus norvegicus (Norway rat)	Potency	13.8993	1	3
Gamma-aminobutyric acid receptor subunit beta-3	Rattus norvegicus (Norway rat)	Potency	13.8993	1	3
Gamma-aminobutyric acid receptor subunit delta	Rattus norvegicus (Norway rat)	Potency	13.8993	1	3
Gamma-aminobutyric acid receptor subunit epsilon	Rattus norvegicus (Norway rat)	Potency	13.8993	1	3
Gamma-aminobutyric acid receptor subunit gamma-1	Rattus norvegicus (Norway rat)	Potency	13.8993	1	3
Gamma-aminobutyric acid receptor subunit gamma-2	Rattus norvegicus (Norway rat)	Potency	13.8993	1	3
Gamma-aminobutyric acid receptor subunit gamma-3	Rattus norvegicus (Norway rat)	Potency	13.8993	1	3
Gamma-aminobutyric acid receptor subunit pi	Rattus norvegicus (Norway rat)	Potency	13.8993	1	3
geminin	Homo sapiens (human)	Potency	23.0367	2	4
GLI family zinc finger 3	Homo sapiens (human)	Potency	26.6032	2	2
glp-1 receptor, partial	Homo sapiens (human)	Potency	8.9125	1	1
glucocerebrosidase	Homo sapiens (human)	Potency	25.1189	1	1
glucocorticoid receptor [Homo sapiens]	Homo sapiens (human)	Potency	22.6142	2	2
Glycoprotein hormones alpha chain	Homo sapiens (human)	Potency	14.1254	1	2
Guanine nucleotide-binding protein G	Homo sapiens (human)	Potency	25.1189	1	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	Homo sapiens (human)	Potency	52.1194	1	1
Histamine H2 receptor	Cavia porcellus (domestic guinea pig)	Potency	12.5893	1	2
histone acetyltransferase KAT2A isoform 1	Homo sapiens (human)	Potency	15.8489	1	1
Histone H2A.x	Cricetulus griseus (Chinese hamster)	Potency	49.1940	1	1
HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)	Potency	24.5454	1	1
hypoxia-inducible factor 1 alpha subunit	Homo sapiens (human)	Potency	26.8325	2	2
Inositol hexakisphosphate kinase 1	Homo sapiens (human)	Potency	24.5454	1	2
Inositol monophosphatase 1	Rattus norvegicus (Norway rat)	Potency	1.4125	1	1
Integrin alpha-IIb	Homo sapiens (human)	Potency	19.9526	1	1
Integrin beta-3	Homo sapiens (human)	Potency	19.9526	1	1
Interferon beta	Homo sapiens (human)	Potency	24.5454	1	1
lamin isoform A-delta10	Homo sapiens (human)	Potency	11.2202	1	1
lethal factor (plasmid)	Bacillus anthracis str. A2012	Potency	17.5594	1	2
M-phase phosphoprotein 8	Homo sapiens (human)	Potency	37.6858	1	1
Microtubule-associated protein tau	Homo sapiens (human)	Potency	40.0748	1	2
mitogen-activated protein kinase 1	Homo sapiens (human)	Potency	25.1189	1	1
muscarinic acetylcholine receptor M1	Rattus norvegicus (Norway rat)	Potency	10.0000	2	2
NFKB1 protein, partial	Homo sapiens (human)	Potency	11.2202	2	2
NPC intracellular cholesterol transporter 1 precursor	Homo sapiens (human)	Potency	58.0479	1	1
nuclear factor erythroid 2-related factor 2 isoform 1	Homo sapiens (human)	Potency	30.7312	2	2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	Homo sapiens (human)	Potency	26.8325	1	1
nuclear receptor ROR-gamma isoform 1	Mus musculus (house mouse)	Potency	31.6228	1	1
peripheral myelin protein 22	Rattus norvegicus (Norway rat)	Potency	18.1056	1	1
peroxisome proliferator activated receptor gamma	Homo sapiens (human)	Potency	23.9145	1	1
phosphopantetheinyl transferase	Bacillus subtilis	Potency	44.1073	1	2
polyprotein	Zika virus	Potency	23.4850	1	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	Homo sapiens (human)	Potency	12.5893	1	1
potassium voltage-gated channel subfamily H member 2 isoform d	Homo sapiens (human)	Potency	12.5893	1	1
pregnane X nuclear receptor	Homo sapiens (human)	Potency	11.2202	1	1
ras-related protein Rab-9A	Homo sapiens (human)	Potency	58.0479	1	1
regulator of G-protein signaling 4	Homo sapiens (human)	Potency	18.8876	1	1
retinoic acid nuclear receptor alpha variant 1	Homo sapiens (human)	Potency	28.2262	2	2
retinoid X nuclear receptor alpha	Homo sapiens (human)	Potency	2.3914	1	1
serine/threonine-protein kinase mTOR isoform 1	Homo sapiens (human)	Potency	15.8841	3	3
Smad3	Homo sapiens (human)	Potency	35.4813	1	1
Spike glycoprotein	Severe acute respiratory syndrome-related coronavirus	Potency	39.8107	1	1
survival motor neuron protein isoform d	Homo sapiens (human)	Potency	31.6228	1	1
TDP1 protein	Homo sapiens (human)	Potency	15.5088	2	8
Thrombopoietin	Homo sapiens (human)	Potency	15.8489	2	2
thyroid hormone receptor beta isoform 2	Rattus norvegicus (Norway rat)	Potency	12.3572	2	2
thyroid stimulating hormone receptor	Homo sapiens (human)	Potency	30.4405	3	3
USP1 protein, partial	Homo sapiens (human)	Potency	48.9252	2	5
v-jun sarcoma virus 17 oncogene homolog (avian)	Homo sapiens (human)	Potency	15.6992	2	2
vitamin D3 receptor isoform VDRA	Homo sapiens (human)	Potency	56.2341	1	1

Inhibition Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	Homo sapiens (human)	Ki	0.0080	1	1
Alpha-1A adrenergic receptor	Rattus norvegicus (Norway rat)	IC50	0.3500	1	1
Alpha-1B adrenergic receptor	Rattus norvegicus (Norway rat)	IC50	0.3500	1	1
Alpha-1D adrenergic receptor	Rattus norvegicus (Norway rat)	IC50	0.3500	1	1
Angiotensin-converting enzyme	Oryctolagus cuniculus (rabbit)	IC50	6.2260	1	1
Angiotensin-converting enzyme	Oryctolagus cuniculus (rabbit)	Ki	5.1008	1	1
ATP-dependent translocase ABCB1	Homo sapiens (human)	IC50	8.1333	3	3
ATP-dependent translocase ABCB1	Homo sapiens (human)	Ki	6.5000	1	1
Beta-glucuronidase	Rattus norvegicus (Norway rat)	IC50	7.8000	1	1
Bile salt export pump	Homo sapiens (human)	IC50	10.0000	2	2
C-8 sterol isomerase	Saccharomyces cerevisiae S288C	Ki	0.5000	1	1
Calcium-dependent protein kinase 4	Plasmodium falciparum 3D7	Ki	150.0000	1	1
D(2) dopamine receptor	Rattus norvegicus (Norway rat)	IC50	0.0160	1	1
DNA-dependent protein kinase catalytic subunit	Homo sapiens (human)	IC50	100.0000	1	1
Emopamil-binding protein-like	Homo sapiens (human)	Ki	0.0039	1	1
Genome polyprotein		IC50	0.7000	1	1
Lysozyme C-1	Rattus norvegicus (Norway rat)	IC50	9.0000	1	1
NADPH oxidase 1	Homo sapiens (human)	IC50	17.0000	1	1
Nuclear receptor subfamily 3 group C member 3	Bos taurus (cattle)	IC50	6.2260	1	1
Nuclear receptor subfamily 3 group C member 3	Bos taurus (cattle)	Ki	5.1008	1	1
Pleiotropic ABC efflux transporter of multiple drugs	Saccharomyces cerevisiae S288C	IC50	1.4000	1	1
Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)	IC50	6.2260	1	1
Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)	Ki	5.1008	1	1
Protein kinase C alpha type	Rattus norvegicus (Norway rat)	IC50	500.0000	1	1
Protein kinase C beta type	Rattus norvegicus (Norway rat)	IC50	500.0000	1	1
Protein kinase C delta type	Rattus norvegicus (Norway rat)	IC50	500.0000	1	1
Protein kinase C epsilon type	Rattus norvegicus (Norway rat)	IC50	500.0000	1	1
Protein kinase C eta type	Rattus norvegicus (Norway rat)	IC50	500.0000	1	1
Protein kinase C gamma type	Rattus norvegicus (Norway rat)	IC50	500.0000	1	1
Protein kinase C theta type	Rattus norvegicus (Norway rat)	IC50	500.0000	1	1
Protein kinase C zeta type	Rattus norvegicus (Norway rat)	IC50	500.0000	1	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	Oryctolagus cuniculus (rabbit)	IC50	45.0000	1	1
Sigma non-opioid intracellular receptor 1	Homo sapiens (human)	Ki	0.0150	1	1
Trypanothione reductase	Trypanosoma cruzi	IC50	72.0000	1	1
Trypanothione reductase	Trypanosoma cruzi	Ki	23.0000	1	1
Ubiquitin carboxyl-terminal hydrolase 1	Homo sapiens (human)	IC50	8.0000	1	1
WD repeat-containing protein 48	Homo sapiens (human)	IC50	8.0000	1	1

Activation Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
5-hydroxytryptamine receptor 2A	Rattus norvegicus (Norway rat)	Kd	0.0010	1	1
5-hydroxytryptamine receptor 2B	Rattus norvegicus (Norway rat)	Kd	0.0010	1	1
5-hydroxytryptamine receptor 2C	Rattus norvegicus (Norway rat)	Kd	0.0010	1	1
Albumin	Rattus norvegicus (Norway rat)	Kd	14.0000	1	1
Calmodulin	Bos taurus (cattle)	Kd	3.4000	1	1
Calmodulin-1	Homo sapiens (human)	Kd	1.0000	1	1
D(2) dopamine receptor	Rattus norvegicus (Norway rat)	Kd	0.0005	1	1

Other Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
DNA repair protein RAD52 homolog isoform a	Homo sapiens (human)	AC50	13.0000	1	1
Pleiotropic ABC efflux transporter of multiple drugs	Saccharomyces cerevisiae S288C	INH	8.3000	1	1
Snq2p	Saccharomyces cerevisiae EC1118	INH	6.9000	1	1