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phenylethanolamines
An ethanolamine compound having a phenyl (substituted or unsubstituted) group on the carbon bearing the hydroxy substituent.
ChEBI ID: 25990
Members (14)
| Member | Definition | Role |
|---|---|---|
| 2-hydroxyphenethylamine | The simplest member of the class of phenylethanolamines that is 2-aminoethanol bearing a phenyl substituent at the 1-position. The parent of the phenylethanolamine class. | phenylethanolamine |
| albuterol | A member of the class of phenylethanolamines that is 4-(2-amino-1-hydroxyethyl)-2-(hydroxymethyl)phenol having a tert-butyl group attached to the nirogen atom. It acts as a beta-adrenergic agonist used in the treatment of asthma and chronic obstructive pulmonary disease (COPD). | albuterol |
| bambuterol | A carbamate ester that is terbutaline in which both of the phenolic hydroxy groups have been protected as the corresponding N,N-dimethylcarbamates. A long acting beta-adrenoceptor agonist used in the treatment of asthma, it is a prodrug for terbutaline. | bambuterol |
| bambuterol hydrochloride | The hydrochloride salt of bambuterol. A long acting beta-adrenoceptor agonist used in the treatment of asthma, it is a prodrug for terbutaline. | bambuterol hydrochloride |
| ephedrine | A phenethylamine alkaloid that is 2-phenylethanamine substituted by a methyl group at the amino nitrogen and a methyl and a hydroxy group at position 2 and 1 respectively. | (-)-ephedrine |
| formoterol fumarate | A phenylethanoloamine having 4-hydroxy and 3-formamido substituents on the phenyl ring and an N-(4-methoxyphenyl)propan-2-yl substituent. | N-[2-hydroxy-5-(1-hydroxy-2-{[1-(4-methoxyphenyl)propan-2-yl]amino}ethyl)phenyl]formamide |
| L-isoprenaline | An optically active phenylethanolamine compound having an isopropyl substituent attached to the nitrogen atom. | L-isoprenaline |
| metaproterenol | 5-[1-hydroxy-2-(isopropanylamino)ethyl]benzene-1,3-diol; metaproterenol | |
| metaraminol | A member of the class of phenylethanolamines that is 2-amino-1-phenylethanol substituted by a methyl group at position 2 and a phenolic hydroxy group at position 1. A sympathomimetic agent , it is used in the treatment of hypotension. | metaraminol |
| n-methylphenylethanolamine | An alkaloid that is ethanolamine having the phenyl group at the 1-position and a methyl group attached to the nitrogen. It has been isolated from Halostachys caspica. | N-methylphenylethanolamine |
| octopamine | A member of the class of phenylethanolamines that is phenol which is substituted at the para- position by a 2-amino-1-hydroxyethyl group. A biogenic phenylethanolamine which has been found to act as a neurotransmitter, neurohormone or neuromodulator in invertebrates. | octopamine |
| phenylephrine | A member of the class of the class of phenylethanolamines that is (1R)-2-(methylamino)-1-phenylethan-1-ol carrying an additional hydroxy substituent at position 3 on the phenyl ring. | phenylephrine |
| pseudoephedrine | A member of the class of the class of phenylethanolamines that is (1S)-2-(methylamino)-1-phenylethan-1-ol in which the pro-S hydrogen at position 2 is replaced by a methyl group. | pseudoephedrine |
| terbutaline | A member of the class of phenylethanolamines that is catechol substituted at position 5 by a 2-(tert-butylamino)-1-hydroxyethyl group. | terbutaline |
Research
Studies (33,073)
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 12,300 (37.19) | 18.7374 |
| 1990's | 7,576 (22.91) | 18.2507 |
| 2000's | 7,155 (21.63) | 29.6817 |
| 2010's | 4,886 (14.77) | 24.3611 |
| 2020's | 1,156 (3.50) | 2.80 |
Study Types
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 5,939 (16.08%) | 5.53% |
| Reviews | 1,376 (3.73%) | 6.00% |
| Case Studies | 1,756 (4.76%) | 4.05% |
| Observational | 83 (0.22%) | 0.25% |
| Other | 27,772 (75.21%) | 84.16% |