An EC 1.11.1.* (peroxidases) inhibitor that inhibits the action of L-ascorbate peroxidase (EC 1.11.1.11).
ChEBI ID: 73181
| Member | Definition | Class |
|---|---|---|
| 2,6-dichloroisonicotinic acid | A member of the class of pyridines that is isonicotinic acid which is substituted by chlorine at positions 2 and 6. | 2,6-dichloroisonicotinic acid |
| salicylic acid | A monohydroxybenzoic acid that is benzoic acid with a hydroxy group at the ortho position. It is obtained from the bark of the white willow and wintergreen leaves. | salicylic acid |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 5,099 (23.94) | 18.7374 |
| 1990's | 2,739 (12.86) | 18.2507 |
| 2000's | 4,174 (19.60) | 29.6817 |
| 2010's | 6,414 (30.12) | 24.3611 |
| 2020's | 2,871 (13.48) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 771 (3.37%) | 5.53% |
| Reviews | 1,469 (6.41%) | 6.00% |
| Case Studies | 5,974 (26.08%) | 4.05% |
| Observational | 68 (0.30%) | 0.25% |
| Other | 14,621 (63.84%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 29.9033 | 1 | 2 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 2 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| chaperonin-containing TCP-1 beta subunit homolog | Homo sapiens (human) | Potency | 70.7946 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 2.5004 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 1.9953 | 1 | 1 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 41.2733 | 2 | 2 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 63.0957 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Acetylcholinesterase | Homo sapiens (human) | IC50 | 346.0000 | 1 | 1 |
| Albumin | Homo sapiens (human) | Ki | 5,888,440,000.0000 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| Bile salt export pump | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| Carbonic anhydrase | Dicentrarchus labrax (European seabass) | Ki | 324.0000 | 1 | 1 |
| Carbonic anhydrase 1 | Homo sapiens (human) | IC50 | 560.0000 | 1 | 1 |
| Carbonic anhydrase 1 | Homo sapiens (human) | Ki | 170.9424 | 5 | 17 |
| Carbonic anhydrase 12 | Homo sapiens (human) | Ki | 161.7929 | 2 | 14 |
| Carbonic anhydrase 13 | Mus musculus (house mouse) | Ki | 165.9500 | 2 | 14 |
| Carbonic anhydrase 14 | Homo sapiens (human) | Ki | 164.7214 | 2 | 14 |
| Carbonic anhydrase 15 | Mus musculus (house mouse) | Ki | 7.2000 | 1 | 1 |
| Carbonic anhydrase 2 | Homo sapiens (human) | IC50 | 680.0000 | 1 | 1 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 177.5071 | 5 | 17 |
| Carbonic anhydrase 3 | Homo sapiens (human) | Ki | 224.3786 | 2 | 14 |
| Carbonic anhydrase 4 | Homo sapiens (human) | Ki | 161.9571 | 2 | 14 |
| Carbonic anhydrase 5A, mitochondrial | Homo sapiens (human) | Ki | 209.5929 | 2 | 14 |
| Carbonic anhydrase 5B, mitochondrial | Homo sapiens (human) | Ki | 186.5214 | 2 | 14 |
| Carbonic anhydrase 6 | Homo sapiens (human) | Ki | 305.8800 | 3 | 15 |
| Carbonic anhydrase 7 | Homo sapiens (human) | Ki | 167.0286 | 2 | 14 |
| Carbonic anhydrase 9 | Homo sapiens (human) | Ki | 160.9133 | 3 | 15 |
| Cystathionine gamma-lyase | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| Nicotinate phosphoribosyltransferase | Homo sapiens (human) | Ki | 0.0002 | 1 | 1 |
| Polyphenol oxidase 2 | Agaricus bisporus | IC50 | 100.0000 | 1 | 1 |
| Prolyl 4-hydroxylase subunit alpha-1 | Gallus gallus (chicken) | Ki | 2,300.0000 | 1 | 1 |
| Prostaglandin G/H synthase 1 | Homo sapiens (human) | IC50 | 270.0000 | 2 | 2 |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| Solute carrier family 22 member 20 | Mus musculus (house mouse) | Ki | 43.8258 | 1 | 2 |
| Solute carrier family 22 member 6 | Homo sapiens (human) | IC50 | 280.0000 | 1 | 1 |
| Solute carrier family 22 member 6 | Mus musculus (house mouse) | Ki | 144.7720 | 1 | 2 |
| Solute carrier family 22 member 6 | Rattus norvegicus (Norway rat) | Ki | 670.5000 | 2 | 2 |
| Solute carrier family 22 member 8 | Homo sapiens (human) | Ki | 1,020.0000 | 1 | 1 |
| Tyrosine-protein phosphatase non-receptor type 1 | Homo sapiens (human) | Ki | 19,400.0000 | 1 | 1 |
| Tyrosine-protein phosphatase YopH | Yersinia pseudotuberculosis IP 32953 | Ki | 1,000.0000 | 1 | 1 |
| Ubiquitin-like domain-containing CTD phosphatase 1 | Homo sapiens (human) | IC50 | 66,000.0000 | 1 | 1 |
| Xanthine dehydrogenase/oxidase | Bos taurus (cattle) | Ki | 100,000.0000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| High mobility group protein B1 | Homo sapiens (human) | Kd | 1.0000 | 2 | 2 |
| Polymerase acidic protein | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) | EC50 | 250.0000 | 1 | 1 |
| Stromelysin-1 | Homo sapiens (human) | Kd | 25,000.0000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 5'-AMP-activated protein kinase catalytic subunit alpha-1 | Homo sapiens (human) | A0.5 | 1,000.0000 | 1 | 1 |
| 5'-AMP-activated protein kinase catalytic subunit alpha-2 | Homo sapiens (human) | A0.5 | 1,000.0000 | 1 | 1 |
| 5'-AMP-activated protein kinase subunit beta-1 | Homo sapiens (human) | A0.5 | 1,000.0000 | 1 | 1 |
| 5'-AMP-activated protein kinase subunit beta-2 | Homo sapiens (human) | A0.5 | 1,000.0000 | 1 | 1 |
| 5'-AMP-activated protein kinase subunit gamma-1 | Homo sapiens (human) | A0.5 | 1,000.0000 | 1 | 1 |
| 5'-AMP-activated protein kinase subunit gamma-2 | Homo sapiens (human) | A0.5 | 1,000.0000 | 1 | 1 |
| 5'-AMP-activated protein kinase subunit gamma-3 | Homo sapiens (human) | A0.5 | 1,000.0000 | 1 | 1 |
| Estrogen receptor | Mus musculus (house mouse) | Kis | 19,400.0000 | 1 | 4 |
| Estrogen receptor beta | Mus musculus (house mouse) | Kis | 19,400.0000 | 1 | 4 |
| Inhibitor of nuclear factor kappa-B kinase subunit beta | Homo sapiens (human) | INH | 1,000.0000 | 1 | 1 |
| Polyphenol oxidase 2 | Agaricus bisporus | ID50 | 3,900.0000 | 1 | 1 |
| Solute carrier family 22 member 7 | Rattus norvegicus (Norway rat) | Km | 85.0000 | 2 | 2 |
| Tyrosine-protein phosphatase non-receptor type 1 | Homo sapiens (human) | Activity | 19,400.0000 | 1 | 1 |
| Tyrosine-protein phosphatase non-receptor type 1 | Homo sapiens (human) | Kis | 19,400.0000 | 1 | 1 |