oneirogen

Any substance that produces or enhances dream-like states of consciousness.

ChEBI ID: 146270

Members (6)

Member	Definition	Class
dextromethorphan	A 6-methoxy-11-methyl-1,3,4,9,10,10a-hexahydro-2H-10,4a-(epiminoethano)phenanthrene in which the sterocenters at positions 4a, 10 and 10a have S-configuration. It is a prodrug of dextrorphan and used as an antitussive drug for suppressing cough.	dextromethorphan
diphenhydramine	An ether that is the benzhydryl ether of 2-(dimethylamino)ethanol. It is a H1-receptor antagonist used as a antipruritic and antitussive drug.	diphenhydramine
harmaline	A harmala alkaloid in which the harman skeleton is methoxy-substituted at C-7 and has been reduced across the 3,4 bond.	harmaline
mirtazapine		mirtazapine
muscimol	A member of the class of isoxazoles that is 1,2-oxazol-3(2H)-one substituted by an aminomethyl group at position 5. It has been isolated from mushrooms of the genus Amanita.	muscimol
salvinorin a		salvinorin A

Research

Studies (12,390)

Timeframe	Studies, Drugs with This Role(%)	All Drugs %
pre-1990	3,869 (31.23)	18.7374
1990's	2,408 (19.44)	18.2507
2000's	2,935 (23.69)	29.6817
2010's	2,552 (20.60)	24.3611
2020's	626 (5.05)	2.80

Study Types

Publication Type	Studies, Drugs with this Role (%)	All Drugs (%)
Trials	1,099 (8.27%)	5.53%
Reviews	590 (4.44%)	6.00%
Case Studies	1,197 (9.01%)	4.05%
Observational	13 (0.10%)	0.25%
Other	10,384 (78.18%)	84.16%

Protein Targets (209)

Potency Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	Homo sapiens (human)	Potency	32.9090	1	3
aldehyde dehydrogenase 1 family, member A1	Homo sapiens (human)	Potency	30.8679	1	4
alpha-galactosidase	Homo sapiens (human)	Potency	35.4813	1	1
AR protein	Homo sapiens (human)	Potency	28.4224	1	1
arylsulfatase A	Homo sapiens (human)	Potency	2.3934	1	1
ATAD5 protein, partial	Homo sapiens (human)	Potency	9.2000	1	1
Ataxin-2	Homo sapiens (human)	Potency	39.8107	1	1
ATP-dependent phosphofructokinase	Trypanosoma brucei brucei TREU927	Potency	0.7569	1	1
Bloom syndrome protein isoform 1	Homo sapiens (human)	Potency	35.4813	1	1
caspase-1 isoform alpha precursor	Homo sapiens (human)	Potency	12.5893	1	2
Caspase-7	Homo sapiens (human)	Potency	11.2947	1	2
Cellular tumor antigen p53	Homo sapiens (human)	Potency	26.7721	2	3
Chain A, 2-oxoglutarate Oxygenase	Homo sapiens (human)	Potency	26.8282	1	4
Chain A, ATP-DEPENDENT DNA HELICASE Q1	Homo sapiens (human)	Potency	33.2418	2	3
Chain A, Beta-lactamase	Escherichia coli K-12	Potency	0.3162	1	1
Chain A, Cruzipain	Trypanosoma cruzi	Potency	10.0000	1	1
Chain A, Ferritin light chain	Equus caballus (horse)	Potency	35.4813	1	1
Chain A, HADH2 protein	Homo sapiens (human)	Potency	32.1841	2	3
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	Homo sapiens (human)	Potency	34.8936	1	2
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	Homo sapiens (human)	Potency	6.3096	1	1
Chain B, HADH2 protein	Homo sapiens (human)	Potency	32.1841	2	3
cytochrome P450 2C19 precursor	Homo sapiens (human)	Potency	19.9304	1	2
cytochrome P450 2C9 precursor	Homo sapiens (human)	Potency	0.0501	1	1
cytochrome P450 2D6	Homo sapiens (human)	Potency	4.3649	1	1
cytochrome P450 2D6 isoform 1	Homo sapiens (human)	Potency	4.7129	1	5
cytochrome P450 3A4 isoform 1	Homo sapiens (human)	Potency	19.9526	2	2
cytochrome P450 family 3 subfamily A polypeptide 4	Homo sapiens (human)	Potency	15.8489	1	1
DNA polymerase beta	Homo sapiens (human)	Potency	35.4813	1	1
DNA polymerase kappa isoform 1	Homo sapiens (human)	Potency	22.3872	1	1
estrogen nuclear receptor alpha	Homo sapiens (human)	Potency	29.4325	4	4
euchromatic histone-lysine N-methyltransferase 2	Homo sapiens (human)	Potency	44.8976	1	2
EWS/FLI fusion protein	Homo sapiens (human)	Potency	23.0786	4	4
GABA theta subunit	Rattus norvegicus (Norway rat)	Potency	19.9526	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	Rattus norvegicus (Norway rat)	Potency	19.9526	1	1
Gamma-aminobutyric acid receptor subunit alpha-2	Rattus norvegicus (Norway rat)	Potency	19.9526	1	1
Gamma-aminobutyric acid receptor subunit alpha-3	Rattus norvegicus (Norway rat)	Potency	19.9526	1	1
Gamma-aminobutyric acid receptor subunit alpha-4	Rattus norvegicus (Norway rat)	Potency	19.9526	1	1
Gamma-aminobutyric acid receptor subunit alpha-5	Rattus norvegicus (Norway rat)	Potency	19.9526	1	1
Gamma-aminobutyric acid receptor subunit alpha-6	Rattus norvegicus (Norway rat)	Potency	19.9526	1	1
Gamma-aminobutyric acid receptor subunit beta-1	Rattus norvegicus (Norway rat)	Potency	19.9526	1	1
Gamma-aminobutyric acid receptor subunit beta-2	Rattus norvegicus (Norway rat)	Potency	19.9526	1	1
Gamma-aminobutyric acid receptor subunit beta-3	Rattus norvegicus (Norway rat)	Potency	19.9526	1	1
Gamma-aminobutyric acid receptor subunit delta	Rattus norvegicus (Norway rat)	Potency	19.9526	1	1
Gamma-aminobutyric acid receptor subunit epsilon	Rattus norvegicus (Norway rat)	Potency	19.9526	1	1
Gamma-aminobutyric acid receptor subunit gamma-1	Rattus norvegicus (Norway rat)	Potency	19.9526	1	1
Gamma-aminobutyric acid receptor subunit gamma-2	Rattus norvegicus (Norway rat)	Potency	19.9526	1	1
Gamma-aminobutyric acid receptor subunit gamma-3	Rattus norvegicus (Norway rat)	Potency	19.9526	1	1
Gamma-aminobutyric acid receptor subunit pi	Rattus norvegicus (Norway rat)	Potency	19.9526	1	1
geminin	Homo sapiens (human)	Potency	16.1720	2	4
glp-1 receptor, partial	Homo sapiens (human)	Potency	10.0000	1	1
GLS protein	Homo sapiens (human)	Potency	26.3763	2	3
glucocorticoid receptor [Homo sapiens]	Homo sapiens (human)	Potency	26.8325	1	1
GTP-binding nuclear protein Ran isoform 1	Homo sapiens (human)	Potency	1.2995	1	1
Histamine H2 receptor	Cavia porcellus (domestic guinea pig)	Potency	0.0501	1	3
histone acetyltransferase KAT2A isoform 1	Homo sapiens (human)	Potency	22.3872	1	1
huntingtin isoform 2	Homo sapiens (human)	Potency	25.6651	1	2
importin subunit beta-1 isoform 1	Homo sapiens (human)	Potency	1.2995	1	1
Inositol monophosphatase 1	Rattus norvegicus (Norway rat)	Potency	10.0000	1	1
lamin isoform A-delta10	Homo sapiens (human)	Potency	21.2804	1	2
lethal factor (plasmid)	Bacillus anthracis str. A2012	Potency	25.1189	1	1
Luciferase	Photinus pyralis (common eastern firefly)	Potency	14.3818	1	1
lysosomal alpha-glucosidase preproprotein	Homo sapiens (human)	Potency	22.3872	2	2
Microtubule-associated protein tau	Homo sapiens (human)	Potency	16.3608	1	3
muscarinic acetylcholine receptor M1	Rattus norvegicus (Norway rat)	Potency	10.5318	2	5
muscleblind-like protein 1 isoform 1	Homo sapiens (human)	Potency	28.1838	1	1
Neuronal acetylcholine receptor subunit alpha-4	Rattus norvegicus (Norway rat)	Potency	22.3872	1	1
Neuronal acetylcholine receptor subunit beta-2	Rattus norvegicus (Norway rat)	Potency	22.3872	1	1
nuclear receptor ROR-gamma isoform 1	Mus musculus (house mouse)	Potency	12.5893	1	1
phosphopantetheinyl transferase	Bacillus subtilis	Potency	89.1251	1	1
potassium voltage-gated channel subfamily H member 2 isoform d	Homo sapiens (human)	Potency	28.1838	1	1
pregnane X nuclear receptor	Homo sapiens (human)	Potency	22.3872	1	1
regulator of G-protein signaling 4	Homo sapiens (human)	Potency	0.1889	1	1
serine-protein kinase ATM isoform a	Homo sapiens (human)	Potency	35.4813	1	1
snurportin-1	Homo sapiens (human)	Potency	1.2995	1	1
Spike glycoprotein	Severe acute respiratory syndrome-related coronavirus	Potency	39.8107	1	1
TAR DNA-binding protein 43	Homo sapiens (human)	Potency	0.3548	1	1
TDP1 protein	Homo sapiens (human)	Potency	18.4940	2	6
Thrombopoietin	Homo sapiens (human)	Potency	0.0631	2	2
thyroid hormone receptor beta isoform 2	Rattus norvegicus (Norway rat)	Potency	24.3980	2	4
thyroid stimulating hormone receptor	Homo sapiens (human)	Potency	22.8443	2	9
USP1 protein, partial	Homo sapiens (human)	Potency	39.8107	1	1
v-jun sarcoma virus 17 oncogene homolog (avian)	Homo sapiens (human)	Potency	23.0310	2	2
vitamin D3 receptor isoform VDRA	Homo sapiens (human)	Potency	89.1251	1	1

Inhibition Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
5-hydroxytryptamine receptor 1A	Homo sapiens (human)	Ki	0.0180	2	2
5-hydroxytryptamine receptor 1B	Oryctolagus cuniculus (rabbit)	IC50	100.0000	1	1
5-hydroxytryptamine receptor 2A	Homo sapiens (human)	IC50	1.2950	1	1
5-hydroxytryptamine receptor 2A	Homo sapiens (human)	Ki	0.1491	3	3
5-hydroxytryptamine receptor 2A	Rattus norvegicus (Norway rat)	Ki	0.0020	1	1
5-hydroxytryptamine receptor 2B	Homo sapiens (human)	IC50	1.1180	1	1
5-hydroxytryptamine receptor 2B	Homo sapiens (human)	Ki	0.7110	1	1
5-hydroxytryptamine receptor 2C	Homo sapiens (human)	IC50	0.9800	1	1
5-hydroxytryptamine receptor 2C	Homo sapiens (human)	Ki	0.2760	2	2
5-hydroxytryptamine receptor 2C	Rattus norvegicus (Norway rat)	Ki	0.0055	1	1
5-hydroxytryptamine receptor 3A	Homo sapiens (human)	Ki	2.9000	1	1
5-hydroxytryptamine receptor 4	Cavia porcellus (domestic guinea pig)	IC50	0.9800	1	1
5-hydroxytryptamine receptor 4	Cavia porcellus (domestic guinea pig)	Ki	0.5130	1	1
5-hydroxytryptamine receptor 5A	Homo sapiens (human)	Ki	10.0000	1	1
5-hydroxytryptamine receptor 7	Homo sapiens (human)	Ki	0.2650	1	1
Acetylcholinesterase	Electrophorus electricus (electric eel)	IC50	4.9000	1	1
Acetylcholinesterase	Homo sapiens (human)	IC50	23.7000	1	1
Aldo-keto reductase family 1 member B1	Rattus norvegicus (Norway rat)	IC50	3.5420	1	1
Aldo-keto reductase family 1 member B1	Rattus norvegicus (Norway rat)	Ki	3.5130	1	1
Alpha-1A adrenergic receptor	Homo sapiens (human)	IC50	3.1623	1	1
Alpha-1A adrenergic receptor	Rattus norvegicus (Norway rat)	IC50	0.2239	1	1
Alpha-1A adrenergic receptor	Rattus norvegicus (Norway rat)	Ki	0.8290	2	2
Alpha-1B adrenergic receptor	Rattus norvegicus (Norway rat)	IC50	0.2239	1	1
Alpha-1B adrenergic receptor	Rattus norvegicus (Norway rat)	Ki	0.8290	2	2
Alpha-1D adrenergic receptor	Rattus norvegicus (Norway rat)	IC50	0.2239	1	1
Alpha-1D adrenergic receptor	Rattus norvegicus (Norway rat)	Ki	0.8290	2	2
Alpha-2A adrenergic receptor	Homo sapiens (human)	IC50	0.0851	1	1
Alpha-2A adrenergic receptor	Homo sapiens (human)	Ki	0.0200	1	1
Alpha-2B adrenergic receptor	Homo sapiens (human)	IC50	0.2239	1	1
Alpha-2C adrenergic receptor	Homo sapiens (human)	IC50	0.1995	1	1
Alpha-2C adrenergic receptor	Homo sapiens (human)	Ki	0.0180	1	1
Amine oxidase [flavin-containing] A	Homo sapiens (human)	IC50	0.0329	1	1
Amine oxidase [flavin-containing] A	Rattus norvegicus (Norway rat)	IC50	0.0120	1	2
Amine oxidase [flavin-containing] B	Homo sapiens (human)	IC50	100.0000	1	1
Amine oxidase [flavin-containing] B	Rattus norvegicus (Norway rat)	IC50	150.0000	1	2
Angiotensin-converting enzyme	Oryctolagus cuniculus (rabbit)	IC50	31.8590	1	1
Angiotensin-converting enzyme	Oryctolagus cuniculus (rabbit)	Ki	26.1013	1	1
Angiotensin-converting enzyme	Rattus norvegicus (Norway rat)	Ki	0.0180	1	3
ATP-binding cassette sub-family C member 3	Homo sapiens (human)	IC50	133.0000	1	1
Bile salt export pump	Homo sapiens (human)	IC50	134.0000	2	2
Calcium release-activated calcium channel protein 1	Homo sapiens (human)	IC50	500.0000	2	2
Canalicular multispecific organic anion transporter 1	Homo sapiens (human)	IC50	133.0000	1	1
Cytochrome P450 2C9	Homo sapiens (human)	IC50	50.0000	1	2
Cytochrome P450 2D1	Rattus norvegicus (Norway rat)	IC50	264.0000	1	1
Cytochrome P450 2D26	Rattus norvegicus (Norway rat)	IC50	5.6000	1	1
Cytochrome P450 2D3	Rattus norvegicus (Norway rat)	IC50	18.6000	1	1
Cytochrome P450 2D4	Rattus norvegicus (Norway rat)	IC50	136.0000	1	1
Cytochrome P450 2D6	Homo sapiens (human)	IC50	2.1768	5	5
Cytochrome P450 2J2	Homo sapiens (human)	IC50	50.0000	1	2
D	Rattus norvegicus (Norway rat)	Ki	4.1670	1	1
D-amino-acid oxidase	Sus scrofa (pig)	IC50	100.0000	2	2
D(2) dopamine receptor	Homo sapiens (human)	Ki	5.4540	1	1
D(2) dopamine receptor	Rattus norvegicus (Norway rat)	Ki	1.4600	1	2
D(3) dopamine receptor	Homo sapiens (human)	Ki	2.8715	2	2
D(4) dopamine receptor	Homo sapiens (human)	Ki	0.0250	1	1
Delta-type opioid receptor	Homo sapiens (human)	Ki	8.1360	8	10
Delta-type opioid receptor	Mus musculus (house mouse)	Ki	7.0000	4	4
GABA theta subunit	Rattus norvegicus (Norway rat)	IC50	0.0054	5	8
GABA theta subunit	Rattus norvegicus (Norway rat)	Ki	0.0040	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	Homo sapiens (human)	IC50	0.0160	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	Rattus norvegicus (Norway rat)	IC50	0.0054	5	8
Gamma-aminobutyric acid receptor subunit alpha-1	Homo sapiens (human)	Ki	0.0085	2	2
Gamma-aminobutyric acid receptor subunit alpha-1	Rattus norvegicus (Norway rat)	Ki	0.0040	1	1
Gamma-aminobutyric acid receptor subunit alpha-2	Homo sapiens (human)	IC50	0.0160	1	1
Gamma-aminobutyric acid receptor subunit alpha-2	Rattus norvegicus (Norway rat)	IC50	0.0054	5	8
Gamma-aminobutyric acid receptor subunit alpha-2	Homo sapiens (human)	Ki	0.0085	2	2
Gamma-aminobutyric acid receptor subunit alpha-2	Rattus norvegicus (Norway rat)	Ki	0.0040	1	1
Gamma-aminobutyric acid receptor subunit alpha-3	Homo sapiens (human)	IC50	0.0160	1	1
Gamma-aminobutyric acid receptor subunit alpha-3	Rattus norvegicus (Norway rat)	IC50	0.0054	5	8
Gamma-aminobutyric acid receptor subunit alpha-3	Homo sapiens (human)	Ki	0.0085	2	2
Gamma-aminobutyric acid receptor subunit alpha-3	Rattus norvegicus (Norway rat)	Ki	0.0040	1	1
Gamma-aminobutyric acid receptor subunit alpha-4	Homo sapiens (human)	IC50	0.0160	1	1
Gamma-aminobutyric acid receptor subunit alpha-4	Rattus norvegicus (Norway rat)	IC50	0.0054	5	8
Gamma-aminobutyric acid receptor subunit alpha-4	Homo sapiens (human)	Ki	0.0085	2	2
Gamma-aminobutyric acid receptor subunit alpha-4	Rattus norvegicus (Norway rat)	Ki	0.0040	1	1
Gamma-aminobutyric acid receptor subunit alpha-5	Homo sapiens (human)	IC50	0.0160	1	1
Gamma-aminobutyric acid receptor subunit alpha-5	Rattus norvegicus (Norway rat)	IC50	0.0054	5	8
Gamma-aminobutyric acid receptor subunit alpha-5	Homo sapiens (human)	Ki	0.0085	2	2
Gamma-aminobutyric acid receptor subunit alpha-5	Rattus norvegicus (Norway rat)	Ki	0.0040	1	1
Gamma-aminobutyric acid receptor subunit alpha-6	Homo sapiens (human)	IC50	0.0160	1	1
Gamma-aminobutyric acid receptor subunit alpha-6	Rattus norvegicus (Norway rat)	IC50	0.0054	5	8
Gamma-aminobutyric acid receptor subunit alpha-6	Homo sapiens (human)	Ki	0.0085	2	2
Gamma-aminobutyric acid receptor subunit alpha-6	Rattus norvegicus (Norway rat)	Ki	0.0040	1	1
Gamma-aminobutyric acid receptor subunit beta-1	Homo sapiens (human)	IC50	0.0160	1	1
Gamma-aminobutyric acid receptor subunit beta-1	Rattus norvegicus (Norway rat)	IC50	0.0054	5	8
Gamma-aminobutyric acid receptor subunit beta-1	Homo sapiens (human)	Ki	0.0085	2	2
Gamma-aminobutyric acid receptor subunit beta-1	Rattus norvegicus (Norway rat)	Ki	0.0040	1	1
Gamma-aminobutyric acid receptor subunit beta-2	Homo sapiens (human)	IC50	0.0160	1	1
Gamma-aminobutyric acid receptor subunit beta-2	Rattus norvegicus (Norway rat)	IC50	0.0054	5	8
Gamma-aminobutyric acid receptor subunit beta-2	Homo sapiens (human)	Ki	0.0085	2	2
Gamma-aminobutyric acid receptor subunit beta-2	Rattus norvegicus (Norway rat)	Ki	0.0040	1	1
Gamma-aminobutyric acid receptor subunit beta-3	Homo sapiens (human)	IC50	0.0160	1	1
Gamma-aminobutyric acid receptor subunit beta-3	Rattus norvegicus (Norway rat)	IC50	0.0054	5	8
Gamma-aminobutyric acid receptor subunit beta-3	Homo sapiens (human)	Ki	0.0085	2	2
Gamma-aminobutyric acid receptor subunit beta-3	Rattus norvegicus (Norway rat)	Ki	0.0040	1	1
Gamma-aminobutyric acid receptor subunit delta	Homo sapiens (human)	IC50	0.0160	1	1
Gamma-aminobutyric acid receptor subunit delta	Rattus norvegicus (Norway rat)	IC50	0.0054	5	8
Gamma-aminobutyric acid receptor subunit delta	Homo sapiens (human)	Ki	0.0085	2	2
Gamma-aminobutyric acid receptor subunit delta	Rattus norvegicus (Norway rat)	Ki	0.0040	1	1
Gamma-aminobutyric acid receptor subunit epsilon	Homo sapiens (human)	IC50	0.0160	1	1
Gamma-aminobutyric acid receptor subunit epsilon	Rattus norvegicus (Norway rat)	IC50	0.0054	5	8
Gamma-aminobutyric acid receptor subunit epsilon	Homo sapiens (human)	Ki	0.0085	2	2
Gamma-aminobutyric acid receptor subunit epsilon	Rattus norvegicus (Norway rat)	Ki	0.0040	1	1
Gamma-aminobutyric acid receptor subunit gamma-1	Homo sapiens (human)	IC50	0.0160	1	1
Gamma-aminobutyric acid receptor subunit gamma-1	Rattus norvegicus (Norway rat)	IC50	0.0055	6	9
Gamma-aminobutyric acid receptor subunit gamma-1	Homo sapiens (human)	Ki	0.0085	2	2
Gamma-aminobutyric acid receptor subunit gamma-1	Rattus norvegicus (Norway rat)	Ki	0.0040	1	1
Gamma-aminobutyric acid receptor subunit gamma-2	Homo sapiens (human)	IC50	0.0160	1	1
Gamma-aminobutyric acid receptor subunit gamma-2	Rattus norvegicus (Norway rat)	IC50	0.0054	5	8
Gamma-aminobutyric acid receptor subunit gamma-2	Homo sapiens (human)	Ki	0.0085	2	2
Gamma-aminobutyric acid receptor subunit gamma-2	Rattus norvegicus (Norway rat)	Ki	0.0040	1	1
Gamma-aminobutyric acid receptor subunit gamma-3	Homo sapiens (human)	IC50	0.0160	1	1
Gamma-aminobutyric acid receptor subunit gamma-3	Rattus norvegicus (Norway rat)	IC50	0.0054	5	8
Gamma-aminobutyric acid receptor subunit gamma-3	Homo sapiens (human)	Ki	0.0085	2	2
Gamma-aminobutyric acid receptor subunit gamma-3	Rattus norvegicus (Norway rat)	Ki	0.0040	1	1
Gamma-aminobutyric acid receptor subunit pi	Homo sapiens (human)	IC50	0.0160	1	1
Gamma-aminobutyric acid receptor subunit pi	Rattus norvegicus (Norway rat)	IC50	0.0054	5	8
Gamma-aminobutyric acid receptor subunit pi	Homo sapiens (human)	Ki	0.0085	2	2
Gamma-aminobutyric acid receptor subunit pi	Rattus norvegicus (Norway rat)	Ki	0.0040	1	1
Gamma-aminobutyric acid receptor subunit theta	Homo sapiens (human)	IC50	0.0160	1	1
Gamma-aminobutyric acid receptor subunit theta	Homo sapiens (human)	Ki	0.0085	2	2
Glutamate receptor ionotropic, NMDA 1	Homo sapiens (human)	Ki	1.6800	1	1
Glutamate receptor ionotropic, NMDA 1	Rattus norvegicus (Norway rat)	Ki	2.2460	1	1
Glutamate receptor ionotropic, NMDA 2A	Homo sapiens (human)	Ki	1.6800	1	1
Glutamate receptor ionotropic, NMDA 2A	Rattus norvegicus (Norway rat)	Ki	2.2460	1	1
Glutamate receptor ionotropic, NMDA 2B	Homo sapiens (human)	Ki	1.6800	1	1
Glutamate receptor ionotropic, NMDA 2B	Rattus norvegicus (Norway rat)	Ki	2.2460	1	1
Glutamate receptor ionotropic, NMDA 2C	Homo sapiens (human)	Ki	1.6800	1	1
Glutamate receptor ionotropic, NMDA 2C	Rattus norvegicus (Norway rat)	Ki	2.2460	1	1
Glutamate receptor ionotropic, NMDA 2D	Homo sapiens (human)	Ki	1.6800	1	1
Glutamate receptor ionotropic, NMDA 2D	Rattus norvegicus (Norway rat)	Ki	2.2460	1	1
Glutamate receptor ionotropic, NMDA 3A	Homo sapiens (human)	Ki	1.6800	1	1
Glutamate receptor ionotropic, NMDA 3A	Rattus norvegicus (Norway rat)	Ki	2.2460	1	1
Glutamate receptor ionotropic, NMDA 3B	Homo sapiens (human)	Ki	1.6800	1	1
Glutamate receptor ionotropic, NMDA 3B	Rattus norvegicus (Norway rat)	Ki	2.2460	1	1
Histamine H1 receptor	Homo sapiens (human)	IC50	0.1710	1	1
Histamine H1 receptor	Homo sapiens (human)	Ki	0.0121	3	3
Histamine H4 receptor	Homo sapiens (human)	Ki	42.6579	1	1
Kappa-type opioid receptor	Homo sapiens (human)	Ki	0.3451	20	49
Kappa-type opioid receptor	Mus musculus (house mouse)	Ki	0.0187	1	1
Kappa-type opioid receptor	Rattus norvegicus (Norway rat)	Ki	0.4921	22	23
Mu-type opioid receptor	Homo sapiens (human)	Ki	5.4156	7	9
Mu-type opioid receptor	Rattus norvegicus (Norway rat)	Ki	7.0000	4	4
Multidrug resistance-associated protein 4	Homo sapiens (human)	IC50	133.0000	1	1
Muscarinic acetylcholine receptor M1	Homo sapiens (human)	IC50	0.3460	1	1
Muscarinic acetylcholine receptor M1	Homo sapiens (human)	Ki	0.0830	1	1
Muscarinic acetylcholine receptor M2	Homo sapiens (human)	IC50	1.0500	1	1
Muscarinic acetylcholine receptor M2	Homo sapiens (human)	Ki	0.3730	1	1
Muscarinic acetylcholine receptor M2	Rattus norvegicus (Norway rat)	Ki	10.0000	1	1
Muscarinic acetylcholine receptor M3	Homo sapiens (human)	IC50	0.6470	1	1
Muscarinic acetylcholine receptor M3	Homo sapiens (human)	Ki	0.1370	1	1
Muscarinic acetylcholine receptor M4	Homo sapiens (human)	IC50	0.3720	1	1
Muscarinic acetylcholine receptor M4	Homo sapiens (human)	Ki	0.0520	1	1
Muscarinic acetylcholine receptor M5	Homo sapiens (human)	IC50	0.1620	1	1
Muscarinic acetylcholine receptor M5	Homo sapiens (human)	Ki	0.1160	1	1
Neuronal acetylcholine receptor subunit alpha-3	Rattus norvegicus (Norway rat)	IC50	11.0500	1	1
Neuronal acetylcholine receptor subunit beta-4	Rattus norvegicus (Norway rat)	IC50	11.0500	1	1
Nuclear receptor subfamily 3 group C member 3	Bos taurus (cattle)	IC50	31.8590	1	1
Nuclear receptor subfamily 3 group C member 3	Bos taurus (cattle)	Ki	26.1013	1	1
Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)	IC50	20.0626	6	6
Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)	Ki	26.1013	1	1
Protein orai-2	Homo sapiens (human)	IC50	500.0000	2	2
Protein orai-3	Homo sapiens (human)	IC50	500.0000	2	2
Sigma non-opioid intracellular receptor 1	Cavia porcellus (domestic guinea pig)	IC50	0.1236	2	2
Sigma non-opioid intracellular receptor 1	Cavia porcellus (domestic guinea pig)	Ki	0.0365	2	2
Sigma non-opioid intracellular receptor 1	Homo sapiens (human)	Ki	0.3480	1	1
Sigma non-opioid intracellular receptor 1	Rattus norvegicus (Norway rat)	Ki	5.0700	1	1
Sodium channel protein type 1 subunit alpha	Rattus norvegicus (Norway rat)	IC50	5.6500	2	2
Sodium channel protein type 2 subunit alpha	Rattus norvegicus (Norway rat)	IC50	5.6500	2	2
Sodium channel protein type 3 subunit alpha	Rattus norvegicus (Norway rat)	IC50	5.6500	2	2
Sodium channel protein type 5 subunit alpha	Homo sapiens (human)	IC50	41.0000	1	1
Sodium- and chloride-dependent betaine transporter	Rattus norvegicus (Norway rat)	IC50	0.0032	1	1
Sodium- and chloride-dependent GABA transporter 1	Rattus norvegicus (Norway rat)	IC50	0.0032	1	1
Sodium- and chloride-dependent GABA transporter 2	Rattus norvegicus (Norway rat)	IC50	0.0032	1	1
Sodium- and chloride-dependent GABA transporter 3	Rattus norvegicus (Norway rat)	IC50	0.0032	1	1
Sodium-dependent dopamine transporter	Rattus norvegicus (Norway rat)	IC50	1.0000	1	3
Sodium-dependent noradrenaline transporter	Homo sapiens (human)	IC50	3.5420	1	1
Sodium-dependent noradrenaline transporter	Homo sapiens (human)	Ki	3.5130	1	1
Sodium-dependent serotonin transporter	Homo sapiens (human)	IC50	0.0027	1	1
Sodium-dependent serotonin transporter	Rattus norvegicus (Norway rat)	IC50	0.7000	2	3
Sodium-dependent serotonin transporter	Homo sapiens (human)	Ki	0.0014	1	1
Solute carrier family 22 member 1	Rattus norvegicus (Norway rat)	IC50	24.0000	1	1
Solute carrier family 22 member 1	Homo sapiens (human)	IC50	12.7250	2	2
Solute carrier family 22 member 2	Rattus norvegicus (Norway rat)	IC50	32.0000	1	1
Transporter	Rattus norvegicus (Norway rat)	IC50	0.5067	2	3
Transporter	Rattus norvegicus (Norway rat)	Ki	1.6400	1	1
Type-2 angiotensin II receptor	Rattus norvegicus (Norway rat)	Ki	0.0180	1	1

Activation Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
5-hydroxytryptamine receptor 1A	Homo sapiens (human)	Kd	5.0119	1	1
Adenosine receptor A2a	Homo sapiens (human)	EC50	0.0038	1	2
Adenosine receptor A2b	Homo sapiens (human)	EC50	0.0038	1	2
Delta-type opioid receptor	Homo sapiens (human)	EC50	10.0000	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	Homo sapiens (human)	EC50	5.8308	3	5
Gamma-aminobutyric acid receptor subunit alpha-2	Homo sapiens (human)	EC50	5.7270	3	5
Gamma-aminobutyric acid receptor subunit alpha-3	Homo sapiens (human)	EC50	5.5695	3	5
Gamma-aminobutyric acid receptor subunit alpha-4	Homo sapiens (human)	EC50	27.0000	1	1
Gamma-aminobutyric acid receptor subunit alpha-5	Homo sapiens (human)	EC50	27.0000	1	1
Gamma-aminobutyric acid receptor subunit alpha-6	Homo sapiens (human)	EC50	27.0000	1	1
Gamma-aminobutyric acid receptor subunit beta-1	Homo sapiens (human)	EC50	27.0000	1	1
Gamma-aminobutyric acid receptor subunit beta-2	Homo sapiens (human)	EC50	2.4336	7	13
Gamma-aminobutyric acid receptor subunit beta-3	Homo sapiens (human)	EC50	27.0000	1	1
Gamma-aminobutyric acid receptor subunit gamma-2	Homo sapiens (human)	EC50	0.3864	6	12
Gamma-aminobutyric acid receptor subunit rho-1	Homo sapiens (human)	EC50	1.0806	4	6
Gamma-aminobutyric acid receptor subunit rho-1	Homo sapiens (human)	Kd	2.3000	1	1
Gamma-aminobutyric acid receptor subunit rho-2	Homo sapiens (human)	Kd	1.4000	1	1
Kappa-type opioid receptor	Homo sapiens (human)	EC50	0.0184	33	60
Kappa-type opioid receptor	Mus musculus (house mouse)	EC50	0.0554	2	2
Mu-type opioid receptor	Homo sapiens (human)	EC50	7.6200	3	3
Taste receptor type 2 member 46	Homo sapiens (human)	EC50	31.0000	1	1

Other Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
Cytochrome P450 2D6	Homo sapiens (human)	Km	1.4000	1	1
Delta-type opioid receptor	Homo sapiens (human)	Ke	5.0000	1	1
dual specificity tyrosine-phosphorylation-regulated kinase 1A	Rattus norvegicus (Norway rat)	AC50	1.2360	1	1
Histamine H1 receptor	Cavia porcellus (domestic guinea pig)	K0.5	0.0061	1	1
Histamine H2 receptor	Cavia porcellus (domestic guinea pig)	K0.5	0.0041	1	7
Histamine H3 receptor	Cavia porcellus (domestic guinea pig)	K0.5	0.0061	1	1
Histamine N-methyltransferase	Homo sapiens (human)	Activity	0.0100	1	1
Kappa-type opioid receptor	Homo sapiens (human)	ED50	0.0400	1	1
Mu-type opioid receptor	Homo sapiens (human)	Ke	5.0000	1	1
STE24	Saccharomyces cerevisiae (brewer's yeast)	AC50	2.7660	1	1