Compounds > 2,5-diketogluconic acid
Page last updated: 2024-12-07

2,5-diketogluconic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

2,5-Diketogluconic acid (2,5-DKG) is a dicarboxylic acid derived from glucose. It is a potent chelator of metal ions, particularly iron, and has shown promise as a potential therapeutic agent for iron overload disorders. 2,5-DKG is synthesized through the oxidation of glucose using various enzymatic or chemical methods. Its ability to chelate iron has been investigated for its potential in treating iron overload conditions such as hemochromatosis and thalassemia. Additionally, 2,5-DKG exhibits antimicrobial activity against certain bacteria. Ongoing research focuses on exploring its potential applications in medicine, agriculture, and other fields.'

2,5-diketogluconic acid: RN given refers to (D-threo)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID102287
CHEBI ID18281
SCHEMBL ID379863
MeSH IDM0101693

Synonyms (18)

Synonym
2,5-dioxo-d-gluconic acid
CHEBI:18281
d-threo-hexo-2,5-diulosonic acid
2,5-didehydro-d-gluconic acid
2,5-diketo-d-gluconic acid
d-threo-2,5-hexodiulosonic acid
2595-33-7
C02780 ,
2,5-diketogluconic acid
hexo-2,5-diulosonic acid
(3s,4s)-3,4,6-trihydroxy-2,5-dioxohexanoic acid
einecs 219-992-3
RXMWXENJQAINCC-DMTCNVIQSA-N
SCHEMBL379863
LMFA01050471
DTXSID30936065
Q27102964
(3s,4s)-3,4,6-trihydroxy-2,5-dioxohexanoicacid
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
Escherichia coli metaboliteAny bacterial metabolite produced during a metabolic reaction in Escherichia coli.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
diketoaldonic acidDioxo carboxylic acids formally derived from aldoses by replacement of two secondary CHOH groups by carbonyl groups.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (50.00)18.7374
1990's1 (16.67)18.2507
2000's2 (33.33)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.23

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.23 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.18 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.23)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
provitamin c
provitamin C: RN given refers to parent cpd; NM refers to (L-xylo)-isomer; structure		210hexose
beta-glucono-1,5-lactone
beta-glucono-1,5-lactone: structure. D-glucono-1,5-lactone : An aldono-1,5-lactone obtained from D-gluconic acid.		210aldono-1,5-lactone;
gluconolactone		animal metabolite;
mouse metabolite
gluconic acid
gluconic acid: zinc gluconate has anti-inflammatory activity; RN given refers to (D)-isomer; all RRs refers to (D)-isomer unless otherwise noted. ketogluconic acid : A gluconic acid that contains a ketonic carbonyl group.. D-gluconic acid : A gluconic acid having D-configuration.		2.4120gluconic acidchelator;
Penicillium metabolite
copper gluconate
Gluconates: Derivatives of gluconic acid (the structural formula HOCH2(CHOH)4COOH), including its salts and esters.		3.2260organic molecular entity
2,3-diketogulonic acid
2,3-Diketogulonic Acid: Metabolite of ASCORBIC ACID and the oxidized form of the lactone DEHYDROASCORBIC ACID.. 2,3-diketogulonic acid : A carbohydrate acid formally derived from gulonic acid by oxidation of the -OH groups at positions 2 and 3 to keto groups.		2.3720
dehydroerythorbic acid
dehydroerythorbic acid: structure given in first source		1.9610
dehydroascorbic acid
Dehydroascorbic Acid: The reversibly oxidized form of ascorbic acid. It is the lactone of 2,3-DIKETOGULONIC ACID and has antiscorbutic activity in man on oral ingestion.. L-dehydroascorbate : An organic anion and the conjugate base of L-dehydroascorbic acid, arising from deprotonation of the acidic C2-position.. L-dehydroascorbic acid : Dehydroascorbic acid having the L-configuration.		2.3720dehydroascorbic acid;
vitamin C		coenzyme;
mouse metabolite
nadp
[no description available]		210
ascorbic acid
Ascorbic Acid: A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.. L-ascorbic acid : The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.. L-ascorbate : The L-enantiomer of ascorbate and conjugate base of L-ascorbic acid, arising from selective deprotonation of the 3-hydroxy group. Required for a range of essential metabolic reactions in all animals and plants.. vitamin C : Any member of a group of vitamers that belong to the chemical structural class called butenolides that exhibit biological activity against vitamin C deficiency in animals. The vitamers include L-ascorbic acid and its salt, ionized and oxidized forms.		2.3720ascorbic acid;
vitamin C		coenzyme;
cofactor;
flour treatment agent;
food antioxidant;
food colour retention agent;
geroprotector;
plant metabolite;
skin lightening agent
isoascorbic acid
isoascorbic acid: food antioxidant; (L)-isomer is ascorbic acid; RN given refers to (D)-isomer; structure		2.3720ascorbic acid
ConditionIndicatedRelationship StrengthStudiesTrials