Roles > iron chelator
Page last updated: 2024-08-05 14:56:54

iron chelator

null

ChEBI ID: 38157

Members (13)

MemberDefinitionClass
beta-citrylglutamic acidAn N-acyl-L-glutamic acid in which the acyl group is specified as beta-citryl.beta-citrylglutamic acid
curcuminA beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.curcumin
deferasiroxA member of the class of triazoles, deferasirox is 1,2,4-triazole substituted by a 4-carboxyphenyl group at position 1 and by 2-hydroxyphenyl groups at positions 3 and 5. An orally active iron chelator, it is used to manage chronic iron overload in patients receiving long-term blood transfusions.deferasirox
deferiproneA member of the class of 4-pyridones that is pyridin-4(1H)-one substituted at positions 1 and 2 by methyl groups and at position 3 by a hydroxy group. A lipid-soluble iron-chelator used for treatment of thalassaemia.deferiprone
deferoxamineAn acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.desferrioxamine B
desferrioxamine b mesylateA methanesulfonate salt obtained by reaction of desferrioxamine B with one molar equivalent of methanesulfonic acid. It is an iron-chelating medicine used to remove excess iron from the body. It binds to iron in the blood, which is then passed out in the urine.desferrioxamine B mesylate
ibuproxamA hydroxamic acid obtained by formal condensation of the carboxy group of ibuprofen with the amino group of hydroxylamine. Used for treatment of pain and inflammation associated with musculoskeletal and joint disorders.ibuproxam
my 12-62cA quinolone consisting of quinolin-4(1H)-one carrying a heptyl substituent at position 2.2-heptyl-4-hydroxyquinoline; 2-heptyl-4-quinolone
my 12-62cA monohydroxyquinoline that is 4-hydroxyquinoline bearing an additional heptyl substituent at position 2.2-heptyl-4-hydroxyquinoline; 2-heptyl-4-quinolone
oxyquinolineA monohydroxyquinoline that is quinoline substituted by a hydroxy group at position 8. Its fungicidal properties are used for the control of grey mould on vines and tomatoes.quinolin-8-ol
pyridoxamineA monohydroxypyridine that is pyridine substituted by a hydroxy group at position 3, an aminomethyl group at position 4, a hydroxymethyl group at position 5 and a methyl group at position 2. The 4-aminomethyl form of vitamin B6, it is used (in the form of the hydrochloride salt) for treatment of diabetic nephropathy.pyridoxamine
pyridoxamine dihydrochlorideA hydrochloride obtained by combining pyridoxamine with two molar equivalents of hydrochloric acid. Used for treatment of diabetic nephropathy.pyridoxamine dihydrochloride
xanthurenic acidA quinolinemonocarboxylic acid that is quinoline-2-carboxylic acid substituted by hydroxy groups at C-4 and C-8.xanthurenic acid

Research

Studies (25,904)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-19902,933 (11.32)18.7374
1990's2,627 (10.14)18.2507
2000's4,316 (16.66)29.6817
2010's10,851 (41.89)24.3611
2020's5,177 (19.99)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials1,156 (4.19%)5.53%
Reviews2,545 (9.22%)6.00%
Case Studies847 (3.07%)4.05%
Observational46 (0.17%)0.25%
Other23,000 (83.35%)84.16%

Protein Targets (278)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1Homo sapiens (human)Potency26.968012
15-lipoxygenase, partialHomo sapiens (human)Potency14.219112
67.9K proteinVaccinia virusPotency22.016412
acetylcholinesteraseHomo sapiens (human)Potency54.384846
activating transcription factor 6Homo sapiens (human)Potency17.884124
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency18.548212
Alpha-synucleinHomo sapiens (human)Potency20.942413
apical membrane antigen 1, AMA1Plasmodium falciparum 3D7Potency7.425914
AR proteinHomo sapiens (human)Potency15.6440941
aryl hydrocarbon receptorHomo sapiens (human)Potency29.823737
ATAD5 protein, partialHomo sapiens (human)Potency26.980123
Ataxin-2Homo sapiens (human)Potency52.298813
ATPase family AAA domain-containing protein 5Homo sapiens (human)Potency52.413625
bromodomain adjacent to zinc finger domain 2BHomo sapiens (human)Potency33.572414
caspase 7, apoptosis-related cysteine proteaseHomo sapiens (human)Potency30.289113
caspase-1 isoform alpha precursorHomo sapiens (human)Potency23.735812
caspase-3Cricetulus griseus (Chinese hamster)Potency2.180011
caspase-3Homo sapiens (human)Potency30.289113
Caspase-7Cricetulus griseus (Chinese hamster)Potency2.180011
Caspase-7Homo sapiens (human)Potency12.589311
Cellular tumor antigen p53Homo sapiens (human)Potency20.4577314
cellular tumor antigen p53 isoform aHomo sapiens (human)Potency39.810722
Chain A, 2-oxoglutarate OxygenaseHomo sapiens (human)Potency16.312219
Chain A, Breast cancer type 1 susceptibility proteinHomo sapiens (human)Potency5.011913
Chain A, CruzipainTrypanosoma cruziPotency31.622811
Chain A, Ferritin light chainEquus caballus (horse)Potency5.120912
Chain A, HADH2 proteinHomo sapiens (human)Potency17.802022
Chain A, JmjC domain-containing histone demethylation protein 3AHomo sapiens (human)Potency36.463214
Chain A, Putative fructose-1,6-bisphosphate aldolaseGiardia intestinalisPotency12.027716
Chain A, TYROSYL-DNA PHOSPHODIESTERASEHomo sapiens (human)Potency18.114314
Chain B, HADH2 proteinHomo sapiens (human)Potency17.802022
chromobox protein homolog 1Homo sapiens (human)Potency69.637513
cytochrome P450 2C19 precursorHomo sapiens (human)Potency3.162311
cytochrome P450 2C9 precursorHomo sapiens (human)Potency2.511911
cytochrome P450 3A4 isoform 1Homo sapiens (human)Potency14.219124
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency2.789912
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency21.954117
DNA dC->dU-editing enzyme APOBEC-3F isoform aHomo sapiens (human)Potency22.387211
DNA dC->dU-editing enzyme APOBEC-3G isoform 1Homo sapiens (human)Potency22.011424
DNA polymerase betaHomo sapiens (human)Potency44.668411
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency52.076413
DNA polymerase kappa isoform 1Homo sapiens (human)Potency57.902312
estrogen nuclear receptor alphaHomo sapiens (human)Potency28.88151035
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency12.073327
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency16.54691034
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency6.726214
EWS/FLI fusion proteinHomo sapiens (human)Potency17.112644
farnesoid X nuclear receptorHomo sapiens (human)Potency25.989149
flap endonuclease 1Homo sapiens (human)Potency60.456612
Fumarate hydrataseHomo sapiens (human)Potency25.673312
GABA theta subunitRattus norvegicus (Norway rat)Potency14.219112
GALC proteinHomo sapiens (human)Potency1.584911
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)Potency14.219112
gemininHomo sapiens (human)Potency8.937329
GLI family zinc finger 3Homo sapiens (human)Potency11.4836311
GLS proteinHomo sapiens (human)Potency15.707414
glucocerebrosidaseHomo sapiens (human)Potency32.464812
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency22.3949412
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency27.297414
GTP-binding nuclear protein Ran isoform 1Homo sapiens (human)Potency35.481311
Guanine nucleotide-binding protein GHomo sapiens (human)Potency40.074822
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)Homo sapiens (human)Potency17.782811
heat shock protein beta-1Homo sapiens (human)Potency9.362526
hemoglobin subunit betaHomo sapiens (human)Potency39.810711
Histamine H2 receptorCavia porcellus (domestic guinea pig)Potency5.615627
histone acetyltransferase KAT2A isoform 1Homo sapiens (human)Potency31.622811
Histone H2A.xCricetulus griseus (Chinese hamster)Potency33.877228
histone-lysine N-methyltransferase 2A isoform 2 precursorHomo sapiens (human)Potency14.125411
huntingtin isoform 2Homo sapiens (human)Potency3.548111
hypoxia-inducible factor 1 alpha subunitHomo sapiens (human)Potency19.273226
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)Homo sapiens (human)Potency6.309622
IDH1Homo sapiens (human)Potency12.780012
importin subunit beta-1 isoform 1Homo sapiens (human)Potency25.665122
Integrin alpha-IIbHomo sapiens (human)Potency39.810711
Integrin beta-3Homo sapiens (human)Potency39.810711
interleukin 8Homo sapiens (human)Potency71.842012
lamin isoform A-delta10Homo sapiens (human)Potency13.388814
lethal factor (plasmid)Bacillus anthracis str. A2012Potency0.539712
LuciferasePhotinus pyralis (common eastern firefly)Potency37.815135
lysosomal alpha-glucosidase preproproteinHomo sapiens (human)Potency24.753412
Microtubule-associated protein tauHomo sapiens (human)Potency3.548112
mitogen-activated protein kinase 1Homo sapiens (human)Potency35.716812
muscleblind-like protein 1 isoform 1Homo sapiens (human)Potency39.810711
neuropeptide S receptor isoform AHomo sapiens (human)Potency0.316211
nonstructural protein 1Influenza A virus (A/WSN/1933(H1N1))Potency5.768212
Nrf2Homo sapiens (human)Potency22.387211
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency22.6285416
nuclear factor erythroid 2-related factor 2 isoform 2Homo sapiens (human)Potency12.451812
nuclear factor NF-kappa-B p105 subunit isoform 1Homo sapiens (human)Potency50.118711
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency2.213715
Nuclear receptor ROR-gammaHomo sapiens (human)Potency18.420312
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency14.8197214
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency20.6931311
ParkinHomo sapiens (human)Potency22.387211
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1Homo sapiens (human)Potency19.952611
peripheral myelin protein 22Rattus norvegicus (Norway rat)Potency20.314811
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency25.4906513
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency16.3759510
phosphopantetheinyl transferaseBacillus subtilisPotency45.725418
PINK1Homo sapiens (human)Potency22.387211
plasminogen precursorMus musculus (house mouse)Potency9.053212
polyproteinZika virusPotency25.673312
polyunsaturated fatty acid lipoxygenase ALOX12Homo sapiens (human)Potency19.952611
Polyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)Potency7.943312
potassium voltage-gated channel subfamily H member 2 isoform dHomo sapiens (human)Potency3.814612
pregnane X nuclear receptorHomo sapiens (human)Potency19.229224
pregnane X receptorRattus norvegicus (Norway rat)Potency79.432811
progesterone receptorHomo sapiens (human)Potency23.359325
pyruvate kinase PKM isoform aHomo sapiens (human)Potency28.183822
RAR-related orphan receptor gammaMus musculus (house mouse)Potency18.0105211
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency12.3571313
retinoid X nuclear receptor alphaHomo sapiens (human)Potency13.3482410
serine/threonine-protein kinase PLK1Homo sapiens (human)Potency26.679511
SMAD family member 2Homo sapiens (human)Potency35.665523
SMAD family member 3Homo sapiens (human)Potency35.665523
Smad3Homo sapiens (human)Potency20.472213
snurportin-1Homo sapiens (human)Potency25.665122
Spike glycoproteinSevere acute respiratory syndrome-related coronavirusPotency19.149812
survival motor neuron protein isoform dHomo sapiens (human)Potency17.488212
TAR DNA-binding protein 43Homo sapiens (human)Potency35.481311
TDP1 proteinHomo sapiens (human)Potency15.9596222
thioredoxin glutathione reductaseSchistosoma mansoniPotency39.810711
thioredoxin reductaseRattus norvegicus (Norway rat)Potency50.118711
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency16.9797317
thyroid hormone receptor beta isoform aHomo sapiens (human)Potency52.131533
thyroid stimulating hormone receptorHomo sapiens (human)Potency24.5980612
thyrotropin-releasing hormone receptorHomo sapiens (human)Potency12.518723
transcriptional regulator ERG isoform 3Homo sapiens (human)Potency15.848911
tumor susceptibility gene 101 proteinHomo sapiens (human)Potency19.952611
urokinase plasminogen activator surface receptor precursorMus musculus (house mouse)Potency9.053212
urokinase-type plasminogen activator precursorMus musculus (house mouse)Potency9.053212
USP1 protein, partialHomo sapiens (human)Potency7.550622
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency4.929826
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency21.2792511
vitamin D3 receptor isoform VDRAHomo sapiens (human)Potency66.896812
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency27.297414

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform aHomo sapiens (human)IC509.699522
10 kDa chaperonin Escherichia coliIC503.000022
10 kDa heat shock protein, mitochondrialHomo sapiens (human)IC508.300011
17-beta-hydroxysteroid dehydrogenase type 2Homo sapiens (human)IC501.730011
26S proteasome non-ATPase regulatory subunit 14Homo sapiens (human)IC50100.000011
60 kDa chaperoninEscherichia coli K-12IC50250.000011
60 kDa chaperonin Escherichia coliIC503.000022
60 kDa heat shock protein, mitochondrialHomo sapiens (human)IC508.300011
72 kDa type IV collagenaseHomo sapiens (human)IC50130.000011
90-kda heat shock protein beta HSP90 beta, partialHomo sapiens (human)IC5050.000011
AcetylcholinesteraseElectrophorus electricus (electric eel)IC50132.130022
AcetylcholinesteraseHomo sapiens (human)IC502.550022
alkaline phosphatase, germ cell type preproproteinHomo sapiens (human)IC50100.000011
alkaline phosphatase, intestinalHomo sapiens (human)IC50100.000011
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproproteinHomo sapiens (human)IC50100.000011
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)IC505.400011
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)IC505.400011
Alpha-1D adrenergic receptorRattus norvegicus (Norway rat)IC505.400011
Alpha-synucleinHomo sapiens (human)IC5081.010022
Amine oxidase [flavin-containing] AHomo sapiens (human)IC503.500033
Amine oxidase [flavin-containing] AHomo sapiens (human)Ki0.710011
Amine oxidase [flavin-containing] BHomo sapiens (human)IC502.573333
Amine oxidase [flavin-containing] BHomo sapiens (human)Ki21.500011
Aminopeptidase NHomo sapiens (human)IC5015.500011
Aminopeptidase NSus scrofa (pig)IC5015.500011
Amyloid-beta precursor proteinHomo sapiens (human)IC509.85413030
ATP-binding cassette sub-family C member 3Homo sapiens (human)IC50133.000011
Beta lactamase (plasmid)Pseudomonas aeruginosaIC507.751011
Beta-secretase 1Homo sapiens (human)IC50343.000011
Bile salt export pumpHomo sapiens (human)IC50529.200022
Botulinum neurotoxin type A Clostridium botulinumIC5016.950022
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)IC501.630011
Canalicular multispecific organic anion transporter 1Homo sapiens (human)IC50133.000011
Catechol O-methyltransferaseHomo sapiens (human)IC502.373622
Catechol O-methyltransferaseRattus norvegicus (Norway rat)IC5021.379611
CDGSH iron-sulfur domain-containing protein 1Homo sapiens (human)IC502.360011
CDGSH iron-sulfur domain-containing protein 1Homo sapiens (human)Ki0.101011
Chain A, Bacterial leucyl aminopeptidaseVibrio proteolyticusKi0.580011
CholinesteraseEquus caballus (horse)IC50300.000011
CholinesteraseHomo sapiens (human)IC502.550022
CREB-binding proteinHomo sapiens (human)IC5025.000044
Cysteine protease Trypanosoma brucei rhodesienseIC507.750011
D-amino-acid oxidaseSus scrofa (pig)IC501.070022
Deoxyhypusine hydroxylaseHomo sapiens (human)IC505.000012
Glutaminyl-peptide cyclotransferaseHomo sapiens (human)IC50208.000011
Glutathione S-transferase PHomo sapiens (human)IC5069.000011
Glycogen synthase kinase-3 betaHomo sapiens (human)IC5017.950011
Glycogen synthase kinase-3 betaRattus norvegicus (Norway rat)IC500.066011
heat shock protein HSP 90-alpha isoform 2Homo sapiens (human)IC5050.000011
Heme oxygenase 1 Rattus norvegicus (Norway rat)IC5010.000011
Heme oxygenase 2Rattus norvegicus (Norway rat)IC5010.000011
Histone acetyltransferase p300Homo sapiens (human)IC5021.916766
Histone deacetylase 1Homo sapiens (human)IC50187.000011
Histone deacetylase 1Homo sapiens (human)Ki50.790011
Histone deacetylase 11 Homo sapiens (human)IC50187.000011
Histone deacetylase 2Homo sapiens (human)IC50187.000011
Histone deacetylase 2Homo sapiens (human)Ki97.670011
Histone deacetylase 3Homo sapiens (human)IC50187.000011
Histone deacetylase 4Homo sapiens (human)IC50187.000011
Histone deacetylase 5Homo sapiens (human)IC50187.000011
Histone deacetylase 6Homo sapiens (human)IC50187.000011
Histone deacetylase 7Homo sapiens (human)IC50187.000011
Histone deacetylase 8Homo sapiens (human)IC50187.000011
Histone deacetylase 8Homo sapiens (human)Ki64.980011
Histone deacetylase 9Homo sapiens (human)IC50187.000011
hypothetical protein SA1422Staphylococcus aureus subsp. aureus N315IC5042.900022
Indoleamine 2,3-dioxygenase 1Homo sapiens (human)IC50750.000011
intestinal alkaline phosphatase precursorMus musculus (house mouse)IC5018.700011
Lactoylglutathione lyaseHomo sapiens (human)Ki0.005011
Lysine-specific demethylase 2AHomo sapiens (human)IC506.800011
Lysine-specific demethylase 2BHomo sapiens (human)IC508.100011
Lysine-specific demethylase 4AHomo sapiens (human)IC503.487137
Lysine-specific demethylase 5AHomo sapiens (human)IC505.000011
Lysine-specific demethylase 5CHomo sapiens (human)IC505.600011
Lysine-specific demethylase 6AHomo sapiens (human)IC504.200011
Lysine-specific demethylase 6BHomo sapiens (human)IC503.950011
Lysine-specific histone demethylase 1AHomo sapiens (human)IC509.600011
Methionine aminopeptidase 1Homo sapiens (human)IC5016.466733
Methionine aminopeptidase 2Homo sapiens (human)IC502.966733
Methylcytosine dioxygenase TET2Homo sapiens (human)IC5046.000011
Microtubule-associated protein tauHomo sapiens (human)IC5054.875044
Multidrug resistance-associated protein 4Homo sapiens (human)IC5036.500011
NACHT, LRR and PYD domains-containing protein 3 Homo sapiens (human)IC5024.200011
Neuronal proto-oncogene tyrosine-protein kinase Src Mus musculus (house mouse)IC502.200011
perilipin-1Homo sapiens (human)IC509.167011
perilipin-5Homo sapiens (human)IC5010.232011
Phospholipase A2Homo sapiens (human)IC5011.100011
Polyamine deacetylase HDAC10Homo sapiens (human)IC50187.000011
Polyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)IC5030.000011
Polyunsaturated fatty acid 5-lipoxygenaseRattus norvegicus (Norway rat)IC5019.062244
Potassium voltage-gated channel subfamily D member 3Homo sapiens (human)IC5050.118711
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)IC503,981.070011
Prostaglandin E synthaseHomo sapiens (human)IC501.800033
Prostaglandin G/H synthase 1Ovis aries (sheep)IC5063.835012
Prostaglandin G/H synthase 1 Rattus norvegicus (Norway rat)IC5010.000011
Prostaglandin G/H synthase 2Homo sapiens (human)IC5063.835012
Prostaglandin G/H synthase 2 Rattus norvegicus (Norway rat)IC5010.000011
Proteasome subunit beta type-5Homo sapiens (human)IC5010.000022
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2IC5031.750012
Replicase polyprotein 1abSevere acute respiratory syndrome-related coronavirusIC5031.750012
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1Oryctolagus cuniculus (rabbit)IC503.000011
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1Oryctolagus cuniculus (rabbit)Ki5.800011
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2Homo sapiens (human)IC507.000011
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2Homo sapiens (human)Ki53.000011
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 Rattus norvegicus (Norway rat)Ki5.800011
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3Homo sapiens (human)IC507.000011
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3Homo sapiens (human)Ki8.600011
Serine/threonine-protein kinase PAK 1Homo sapiens (human)IC5016.000011
Sodium channel protein type 5 subunit alphaHomo sapiens (human)IC50290.309922
Sortase AStreptococcus mutansIC5010.200011
ThermolysinBacillus thermoproteolyticusIC50350.000012
ThermolysinBacillus thermoproteolyticusKi214.000011
Thioredoxin reductase 1, cytoplasmicHomo sapiens (human)IC5040.466733
Thioredoxin reductase 2, mitochondrialHomo sapiens (human)IC5040.466733
Thioredoxin reductase 3Homo sapiens (human)IC5040.466733
Thiosulfate sulfurtransferaseHomo sapiens (human)IC5056.000011
Tissue factorHomo sapiens (human)IC500.013211
toll-like receptor 9Homo sapiens (human)IC508.362011
TPA: protein transporter TIM10Saccharomyces cerevisiae S288CIC5019.700011
TyrosinaseHomo sapiens (human)IC505.000011
Vesicular glutamate transporter 3Rattus norvegicus (Norway rat)Ki190.000011
Voltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)IC501,000.000011
Voltage-dependent L-type calcium channel subunit alpha-1CRattus norvegicus (Norway rat)IC50100.000011
Voltage-dependent L-type calcium channel subunit alpha-1DRattus norvegicus (Norway rat)IC50100.000011
Voltage-dependent L-type calcium channel subunit alpha-1SRattus norvegicus (Norway rat)IC50100.000011

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
5-hydroxytryptamine receptor 4Homo sapiens (human)EC5010.000011
Alpha-synucleinHomo sapiens (human)Kd3.500044
calcineurin A1, putativeCandida dubliniensis CD36EC50180.000011
Flavin reductase (NADPH)Homo sapiens (human)Kd1.704112
heat shock protein 90Candida albicansEC50112.681834
Histone deacetylase 8Homo sapiens (human)EC5011.100011
Hypoxia-inducible factor 1-alphaHomo sapiens (human)EC5017.800011
Lymphocyte antigen 96Homo sapiens (human)Kd379.000011
Lysine-specific demethylase 4AHomo sapiens (human)EC5040.500011
Nuclear factor erythroid 2-related factor 2Homo sapiens (human)EC5021.000011
regulator of G-protein signaling 16Homo sapiens (human)EC501.850011
regulator of G-protein signaling 19Homo sapiens (human)EC504.090011
regulator of G-protein signaling 4Homo sapiens (human)EC501.570011
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2EC5010.000011
Replicase polyprotein 1abSevere acute respiratory syndrome-related coronavirusEC5010.000011
RGS7, partialHomo sapiens (human)EC501.240011
Sodium/bile acid cotransporterHomo sapiens (human)Kd64.300011

Other Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Amyloid-beta precursor proteinHomo sapiens (human)DC500.755022
EWS/FLI fusion proteinHomo sapiens (human)AbsAC35_uM40.250011
Microtubule-associated protein tauHomo sapiens (human)DC50200.000011
Pyridoxal kinaseHomo sapiens (human)Km130.000011
ThermolysinBacillus thermoproteolyticusKm1,576.400011