Roles > antidiarrhoeal drug
Page last updated: 2024-08-05 15:23:11

antidiarrhoeal drug

Any drug found useful in the symptomatic treatment of diarrhoea.

ChEBI ID: 55323

Members (9)

MemberDefinitionClass
bicozamycinA commercially important azabicyclic antibiotic obtained from Streptomyces sapporonensis. It inhibits the Rho protein of E. coli.bicozamycin
difenoxinA piperidinemonocarboxylic acid that is 4-phenylpiperidine-4-carboxylic acid in which the hydrogen attached to the nitrogen atom is substituted by a 3-cyano-3,3-diphenylpropyl group.difenoxin
diphenoxylateA piperidinecarboxylate ester that is the ethyl ester of difenoxin.diphenoxylate
diphenoxylate hydrochlorideThe hydrochloride salt of diphenoxylate.diphenoxylate hydrochloride
isovanillinA member of the class of benzaldehydes that is 4-methoxybenzaldehyde substituted by a hydroxy group at position 3. It is an inhibitor of aldehyde oxidase.isovanillin
kaoliniteAn aluminosilicate soft white mineral named after the hill in China (Kao-ling) from which it was mined for centuries. In its natural state kaolin is a white, soft powder consisting principally of the mineral kaolinite, and varying amounts of other minerals such as muscovite, quartz, feldspar, and anatase. It is used in the manufacture of china and porcelain and also widely used in the production of paper, rubber, paint, drying agents, and many other products.kaolin
loperamideA synthetic piperidine derivative, effective against diarrhoea resulting from gastroenteritis or inflammatory bowel disease.loperamide
loperamide hydrochlorideA hydrochloride obtained by combining loperamide with one equivalent of hydrochloric acid. Used for treatment of diarrhoea resulting from gastroenteritis or inflammatory bowel disease.loperamide hydrochloride
tectochrysinA monohydroxyflavone that is flavone substituted by a hydroxy group at position 4 and a methoxy group at position 7 respectively.tectochrysin

Research

Studies (4,258)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-19901,365 (32.06)18.7374
1990's443 (10.40)18.2507
2000's854 (20.06)29.6817
2010's1,110 (26.07)24.3611
2020's486 (11.41)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials286 (6.25%)5.53%
Reviews196 (4.29%)6.00%
Case Studies219 (4.79%)4.05%
Observational7 (0.15%)0.25%
Other3,866 (84.52%)84.16%

Protein Targets (163)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
15-lipoxygenase, partialHomo sapiens (human)Potency15.848911
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency17.782811
Alpha-synucleinHomo sapiens (human)Potency6.309611
AR proteinHomo sapiens (human)Potency23.0884922
aryl hydrocarbon receptorHomo sapiens (human)Potency6.682422
arylsulfatase AHomo sapiens (human)Potency0.952811
ATAD5 protein, partialHomo sapiens (human)Potency14.238833
Ataxin-2Homo sapiens (human)Potency19.393122
ATPase family AAA domain-containing protein 5Homo sapiens (human)Potency18.833611
atrial natriuretic peptide receptor 2 precursorHomo sapiens (human)Potency23.280911
Bloom syndrome protein isoform 1Homo sapiens (human)Potency0.001322
caspase 7, apoptosis-related cysteine proteaseHomo sapiens (human)Potency33.491511
caspase-3Homo sapiens (human)Potency33.491511
Cellular tumor antigen p53Homo sapiens (human)Potency16.746226
cellular tumor antigen p53 isoform aHomo sapiens (human)Potency25.787712
Chain A, Ferritin light chainEquus caballus (horse)Potency19.952611
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency8.912511
chromobox protein homolog 1Homo sapiens (human)Potency100.000011
cytochrome P450 2C19 precursorHomo sapiens (human)Potency0.398111
cytochrome P450 2C9 precursorHomo sapiens (human)Potency2.511911
cytochrome P450 2C9, partialHomo sapiens (human)Potency15.268413
cytochrome P450 2D6Homo sapiens (human)Potency3.802513
cytochrome P450 2D6 isoform 1Homo sapiens (human)Potency11.711613
cytochrome P450 3A4 isoform 1Homo sapiens (human)Potency7.506024
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency1.697623
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency28.227612
D(1A) dopamine receptorSus scrofa (pig)Potency18.492711
Disintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)Potency5.011911
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency89.125111
endonuclease IVEscherichia coliPotency7.079511
estrogen nuclear receptor alphaHomo sapiens (human)Potency24.5485919
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency4.730811
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency13.8582813
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency5.354012
EWS/FLI fusion proteinHomo sapiens (human)Potency19.285744
farnesoid X nuclear receptorHomo sapiens (human)Potency18.019712
Fumarate hydrataseHomo sapiens (human)Potency6.309611
GVesicular stomatitis virusPotency15.268413
GABA theta subunitRattus norvegicus (Norway rat)Potency7.506012
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)Potency7.506012
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)Potency7.506012
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)Potency7.506012
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)Potency7.506012
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)Potency7.506012
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)Potency7.506012
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)Potency7.506012
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)Potency7.506012
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)Potency7.506012
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)Potency7.506012
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)Potency7.506012
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)Potency7.506012
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)Potency7.506012
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)Potency7.506012
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)Potency7.506012
gemininHomo sapiens (human)Potency17.2735412
GLI family zinc finger 3Homo sapiens (human)Potency23.998023
glp-1 receptor, partialHomo sapiens (human)Potency4.739412
GLS proteinHomo sapiens (human)Potency35.481311
glucocerebrosidaseHomo sapiens (human)Potency28.183811
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency34.056136
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency29.849311
Guanine nucleotide-binding protein GHomo sapiens (human)Potency50.118711
heat shock protein beta-1Homo sapiens (human)Potency14.958911
Histamine H2 receptorCavia porcellus (domestic guinea pig)Potency12.014529
HLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)Potency15.268413
huntingtin isoform 2Homo sapiens (human)Potency39.810711
hypoxia-inducible factor 1 alpha subunitHomo sapiens (human)Potency6.007011
IDH1Homo sapiens (human)Potency18.356411
importin subunit beta-1 isoform 1Homo sapiens (human)Potency50.118711
Inositol hexakisphosphate kinase 1Homo sapiens (human)Potency15.268416
Inositol monophosphatase 1Rattus norvegicus (Norway rat)Potency3.162311
Interferon betaHomo sapiens (human)Potency30.940626
lamin isoform A-delta10Homo sapiens (human)Potency10.850413
LuciferasePhotinus pyralis (common eastern firefly)Potency15.101411
M-phase phosphoprotein 8Homo sapiens (human)Potency0.891311
Microtubule-associated protein tauHomo sapiens (human)Potency2.794412
muscarinic acetylcholine receptor M1Rattus norvegicus (Norway rat)Potency17.900822
neuropeptide S receptor isoform AHomo sapiens (human)Potency10.000011
NPC intracellular cholesterol transporter 1 precursorHomo sapiens (human)Potency5.623411
Nrf2Homo sapiens (human)Potency35.481311
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency10.590122
nuclear factor erythroid 2-related factor 2 isoform 2Homo sapiens (human)Potency29.092911
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency21.313811
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency13.184212
nuclear receptor subfamily 1, group I, member 2Rattus norvegicus (Norway rat)Potency10.000011
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency15.059633
parathyroid hormone/parathyroid hormone-related peptide receptor precursorHomo sapiens (human)Potency47.393612
peripheral myelin protein 22Rattus norvegicus (Norway rat)Potency16.243712
peripheral myelin protein 22 isoform 1Homo sapiens (human)Potency33.807811
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency29.180835
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency2.086412
plasminogen precursorMus musculus (house mouse)Potency9.449412
polyproteinZika virusPotency6.309611
polyunsaturated fatty acid lipoxygenase ALOX12Homo sapiens (human)Potency39.810711
Polyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)Potency16.765813
potassium voltage-gated channel subfamily H member 2 isoform dHomo sapiens (human)Potency0.383713
PPM1D proteinHomo sapiens (human)Potency46.612812
pregnane X nuclear receptorHomo sapiens (human)Potency2.235622
progesterone receptorHomo sapiens (human)Potency4.730811
Rap guanine nucleotide exchange factor 3Homo sapiens (human)Potency39.810711
RAR-related orphan receptor gammaMus musculus (house mouse)Potency14.325123
ras-related protein Rab-9AHomo sapiens (human)Potency58.047912
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency21.131712
retinoid X nuclear receptor alphaHomo sapiens (human)Potency25.331511
serine/threonine-protein kinase mTOR isoform 1Homo sapiens (human)Potency17.142544
Single-stranded DNA cytosine deaminaseHomo sapiens (human)Potency100.000011
SMAD family member 2Homo sapiens (human)Potency10.682211
SMAD family member 3Homo sapiens (human)Potency10.682211
snurportin-1Homo sapiens (human)Potency50.118711
Spike glycoproteinSevere acute respiratory syndrome-related coronavirusPotency14.125411
survival motor neuron protein isoform dHomo sapiens (human)Potency33.048813
TDP1 proteinHomo sapiens (human)Potency14.1147217
thioredoxin reductaseRattus norvegicus (Norway rat)Potency0.751911
ThrombopoietinHomo sapiens (human)Potency12.589322
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency11.125026
thyroid stimulating hormone receptorHomo sapiens (human)Potency18.487824
ubiquitin carboxyl-terminal hydrolase 2 isoform aHomo sapiens (human)Potency5.011911
urokinase plasminogen activator surface receptor precursorMus musculus (house mouse)Potency9.449412
urokinase-type plasminogen activator precursorMus musculus (house mouse)Potency9.449412
USP1 protein, partialHomo sapiens (human)Potency4.466811
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency29.849311

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
5-hydroxytryptamine receptor 2BHomo sapiens (human)IC504.105011
5-hydroxytryptamine receptor 2BHomo sapiens (human)Ki2.613011
5-hydroxytryptamine receptor 7Cavia porcellus (domestic guinea pig)IC5023.700012
Aldehyde oxidaseHomo sapiens (human)IC5015.000011
ATP-dependent translocase ABCB1Homo sapiens (human)IC502.500011
Beta-2 adrenergic receptorHomo sapiens (human)IC503.005011
Beta-2 adrenergic receptorHomo sapiens (human)Ki2.066011
Bile salt export pumpHomo sapiens (human)IC5067.000011
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)IC503.000011
Calmodulin Bos taurus (cattle)IC5012.000011
Cocaine esteraseHomo sapiens (human)IC505.700022
Cocaine esteraseHomo sapiens (human)Ki1.500011
Cytochrome P450 2D6Homo sapiens (human)IC502.000011
D(2) dopamine receptorHomo sapiens (human)Ki5.790011
D(3) dopamine receptorHomo sapiens (human)IC501.337011
D(3) dopamine receptorHomo sapiens (human)Ki1.197022
D(4) dopamine receptorHomo sapiens (human)Ki1.850011
Delta-type opioid receptorHomo sapiens (human)IC500.509522
Delta-type opioid receptorHomo sapiens (human)Ki0.316011
Delta-type opioid receptorRattus norvegicus (Norway rat)Ki0.050111
Histamine H2 receptorHomo sapiens (human)IC503.081011
Histamine H2 receptorHomo sapiens (human)Ki3.030011
Kappa-type opioid receptorHomo sapiens (human)IC501.640022
Kappa-type opioid receptorHomo sapiens (human)Ki1.250011
MeninHomo sapiens (human)IC5069.000011
Mu-type opioid receptorHomo sapiens (human)IC500.001522
Mu-type opioid receptorHomo sapiens (human)Ki0.003434
Mu-type opioid receptorRattus norvegicus (Norway rat)Ki0.000211
neuropeptide Y receptor type 1Homo sapiens (human)IC5035.000011
neuropeptide Y receptor type 2Homo sapiens (human)IC5035.000011
Nociceptin receptorHomo sapiens (human)Ki10.000011
Polyphenol oxidase 2Agaricus bisporusIC50500.000011
Potassium voltage-gated channel subfamily A member 3Homo sapiens (human)IC505.000011
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)IC500.033011
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2IC509.270011
Sigma non-opioid intracellular receptor 1Homo sapiens (human)IC500.628011
Sigma non-opioid intracellular receptor 1Homo sapiens (human)Ki0.264011
Sodium channel protein type 5 subunit alphaHomo sapiens (human)IC500.239011
Sodium-dependent serotonin transporterHomo sapiens (human)IC502.202011
Sodium-dependent serotonin transporterHomo sapiens (human)Ki1.170011
Solute carrier family 22 member 1 Homo sapiens (human)IC5023.700011
Xanthine dehydrogenase/oxidaseHomo sapiens (human)IC5050.000011

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Angiopoietin-1 receptorHomo sapiens (human)Kd5.900011
Angiotensin-converting enzyme 2 Homo sapiens (human)EC505.080015
ATP-dependent translocase ABCB1Homo sapiens (human)Kd6.309611
Calmodulin Bos taurus (cattle)Kd3.500011
Delta-type opioid receptorHomo sapiens (human)EC500.156011
Mu-type opioid receptorCavia porcellus (domestic guinea pig)EC500.058011
Procathepsin LHomo sapiens (human)EC505.080015
Replicase polyprotein 1aSevere acute respiratory syndrome-related coronavirusEC505.080015
Replicase polyprotein 1abBetacoronavirus England 1EC505.080015
Replicase polyprotein 1abHuman coronavirus 229EEC505.080015
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2EC505.080015
Replicase polyprotein 1abSevere acute respiratory syndrome-related coronavirusEC505.080015
Spike glycoproteinBetacoronavirus England 1EC505.080015
Spike glycoproteinSevere acute respiratory syndrome-related coronavirusEC505.080015
Transmembrane protease serine 2Homo sapiens (human)EC505.080015

Other Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
ATP-dependent translocase ABCB1Homo sapiens (human)Km13.800011
Histamine H2 receptorCavia porcellus (domestic guinea pig)K0.52.000017
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