Any drug found useful in the symptomatic treatment of diarrhoea.
| Member | Definition | Class |
|---|
| bicozamycin | A commercially important azabicyclic antibiotic obtained from Streptomyces sapporonensis. It inhibits the Rho protein of E. coli. | bicozamycin |
| difenoxin | A piperidinemonocarboxylic acid that is 4-phenylpiperidine-4-carboxylic acid in which the hydrogen attached to the nitrogen atom is substituted by a 3-cyano-3,3-diphenylpropyl group. | difenoxin |
| diphenoxylate | A piperidinecarboxylate ester that is the ethyl ester of difenoxin. | diphenoxylate |
| diphenoxylate hydrochloride | The hydrochloride salt of diphenoxylate. | diphenoxylate hydrochloride |
| isovanillin | A member of the class of benzaldehydes that is 4-methoxybenzaldehyde substituted by a hydroxy group at position 3. It is an inhibitor of aldehyde oxidase. | isovanillin |
| kaolinite | An aluminosilicate soft white mineral named after the hill in China (Kao-ling) from which it was mined for centuries. In its natural state kaolin is a white, soft powder consisting principally of the mineral kaolinite, and varying amounts of other minerals such as muscovite, quartz, feldspar, and anatase. It is used in the manufacture of china and porcelain and also widely used in the production of paper, rubber, paint, drying agents, and many other products. | kaolin |
| loperamide | A synthetic piperidine derivative, effective against diarrhoea resulting from gastroenteritis or inflammatory bowel disease. | loperamide |
| loperamide hydrochloride | A hydrochloride obtained by combining loperamide with one equivalent of hydrochloric acid. Used for treatment of diarrhoea resulting from gastroenteritis or inflammatory bowel disease. | loperamide hydrochloride |
| tectochrysin | A monohydroxyflavone that is flavone substituted by a hydroxy group at position 4 and a methoxy group at position 7 respectively. | tectochrysin |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 17.7828 | 1 | 1 |
| Alpha-synuclein | Homo sapiens (human) | Potency | 6.3096 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 23.0884 | 9 | 22 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 6.6824 | 2 | 2 |
| arylsulfatase A | Homo sapiens (human) | Potency | 0.9528 | 1 | 1 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 14.2388 | 3 | 3 |
| Ataxin-2 | Homo sapiens (human) | Potency | 19.3931 | 2 | 2 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 18.8336 | 1 | 1 |
| atrial natriuretic peptide receptor 2 precursor | Homo sapiens (human) | Potency | 23.2809 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 0.0013 | 2 | 2 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 33.4915 | 1 | 1 |
| caspase-3 | Homo sapiens (human) | Potency | 33.4915 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 16.7462 | 2 | 6 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 25.7877 | 1 | 2 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 19.9526 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 8.9125 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 100.0000 | 1 | 1 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 0.3981 | 1 | 1 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 2.5119 | 1 | 1 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 15.2684 | 1 | 3 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 3.8025 | 1 | 3 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 11.7116 | 1 | 3 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 7.5060 | 2 | 4 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 1.6976 | 2 | 3 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 28.2276 | 1 | 2 |
| D(1A) dopamine receptor | Sus scrofa (pig) | Potency | 18.4927 | 1 | 1 |
| Disintegrin and metalloproteinase domain-containing protein 17 | Homo sapiens (human) | Potency | 5.0119 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| endonuclease IV | Escherichia coli | Potency | 7.0795 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 24.5485 | 9 | 19 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 4.7308 | 1 | 1 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 13.8582 | 8 | 13 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 5.3540 | 1 | 2 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 19.2857 | 4 | 4 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 18.0197 | 1 | 2 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 6.3096 | 1 | 1 |
| G | Vesicular stomatitis virus | Potency | 15.2684 | 1 | 3 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 7.5060 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 7.5060 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 7.5060 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 7.5060 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 7.5060 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 7.5060 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 7.5060 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 7.5060 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 7.5060 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 7.5060 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 7.5060 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 7.5060 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 7.5060 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 7.5060 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 7.5060 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 7.5060 | 1 | 2 |
| geminin | Homo sapiens (human) | Potency | 17.2735 | 4 | 12 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 23.9980 | 2 | 3 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 4.7394 | 1 | 2 |
| GLS protein | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 34.0561 | 3 | 6 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 29.8493 | 1 | 1 |
| Guanine nucleotide-binding protein G | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 14.9589 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 12.0145 | 2 | 9 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 15.2684 | 1 | 3 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 6.0070 | 1 | 1 |
| IDH1 | Homo sapiens (human) | Potency | 18.3564 | 1 | 1 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 15.2684 | 1 | 6 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1 | 1 |
| Interferon beta | Homo sapiens (human) | Potency | 30.9406 | 2 | 6 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 10.8504 | 1 | 3 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 15.1014 | 1 | 1 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 0.8913 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 2.7944 | 1 | 2 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 17.9008 | 2 | 2 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| NPC intracellular cholesterol transporter 1 precursor | Homo sapiens (human) | Potency | 5.6234 | 1 | 1 |
| Nrf2 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 10.5901 | 2 | 2 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 29.0929 | 1 | 1 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 21.3138 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 13.1842 | 1 | 2 |
| nuclear receptor subfamily 1, group I, member 2 | Rattus norvegicus (Norway rat) | Potency | 10.0000 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 15.0596 | 3 | 3 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 47.3936 | 1 | 2 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 16.2437 | 1 | 2 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 33.8078 | 1 | 1 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 29.1808 | 3 | 5 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 2.0864 | 1 | 2 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 9.4494 | 1 | 2 |
| polyprotein | Zika virus | Potency | 6.3096 | 1 | 1 |
| polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 16.7658 | 1 | 3 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 0.3837 | 1 | 3 |
| PPM1D protein | Homo sapiens (human) | Potency | 46.6128 | 1 | 2 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 2.2356 | 2 | 2 |
| progesterone receptor | Homo sapiens (human) | Potency | 4.7308 | 1 | 1 |
| Rap guanine nucleotide exchange factor 3 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 14.3251 | 2 | 3 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 58.0479 | 1 | 2 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 21.1317 | 1 | 2 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 25.3315 | 1 | 1 |
| serine/threonine-protein kinase mTOR isoform 1 | Homo sapiens (human) | Potency | 17.1425 | 4 | 4 |
| Single-stranded DNA cytosine deaminase | Homo sapiens (human) | Potency | 100.0000 | 1 | 1 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 10.6822 | 1 | 1 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 10.6822 | 1 | 1 |
| snurportin-1 | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 14.1254 | 1 | 1 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 33.0488 | 1 | 3 |
| TDP1 protein | Homo sapiens (human) | Potency | 14.1147 | 2 | 17 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 0.7519 | 1 | 1 |
| Thrombopoietin | Homo sapiens (human) | Potency | 12.5893 | 2 | 2 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 11.1250 | 2 | 6 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 18.4878 | 2 | 4 |
| ubiquitin carboxyl-terminal hydrolase 2 isoform a | Homo sapiens (human) | Potency | 5.0119 | 1 | 1 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 9.4494 | 1 | 2 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 9.4494 | 1 | 2 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 4.4668 | 1 | 1 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 29.8493 | 1 | 1 |