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bile acid
Any member of a group of hydroxy-5beta-cholanic acids occuring in bile, where they are present as the sodium salts of their amides with glycine or taurine. In mammals bile acids almost invariably have 5beta-configuration.
ChEBI ID: 3098
Members (17)
| Member | Definition | Role |
|---|---|---|
| 12-ketolithocholic acid | 12-ketolithocholic acid | |
| 3,7,12-trihydroxycholest-24-enoic acid | 3alpha,7alpha,12alpha-Trihydroxy-5beta-24E-cholesten-26-oic acid | |
| 7-ketolithocholic acid | A bile acid that is lithocholic acid carrying an additional oxo substituent at position 7. | 7-oxolithocholic acid |
| antcin k | antcin K | |
| chenodeoxycholic acid | A dihydroxy-5beta-cholanic acid that is (5beta)-cholan-24-oic acid substituted by hydroxy groups at positions 3 and 7 respectively. | chenodeoxycholic acid |
| cholic acid | A bile acid that is 5beta-cholan-24-oic acid bearing three alpha-hydroxy substituents at position 3, 7 and 12. | cholic acid |
| dehydroeburicoic acid | Dehydroeburicoic acid | |
| deoxycholic acid | A bile acid that is 5beta-cholan-24-oic acid substituted by hydroxy groups at positions 3 and 12 respectively. | deoxycholic acid |
| hyodeoxycholic acid | A member of the class of 5beta-cholanic acids that is (5beta)-cholan-24-oic acid substituted by alpha-hydroxy groups at positions 3 and 6. | hyodeoxycholic acid |
| lithocholic acid | A monohydroxy-5beta-cholanic acid with a alpha-hydroxy substituent at position 3. It is a bile acid obtained from chenodeoxycholic acid by bacterial action. | lithocholic acid |
| methyl cholate | Cholic Acid Methyl Ester | |
| msi 1436 | trodusquemine | |
| muricholic acid | A group of trihydroxy-5beta-cholanic acids that are the 6,7-diastereoisomers of 3alpha,6,7-trihydroxy-5beta-cholan-24-oic acid. | muricholic acids |
| norcholate | Norcholic acid | |
| squalamine | Squalamine | |
| ursocholic acid | A bile acid that is 5beta-cholan-24-oic acid bearing three hydroxy substituents at positions 3alpha, 7beta and 12alpha. | ursocholic acid |
| ursodeoxycholic acid | A bile acid found in the bile of bears (Ursidae) as a conjugate with taurine. Used therapeutically, it prevents the synthesis and absorption of cholesterol and can lead to the dissolution of gallstones. | ursodeoxycholic acid |
Research
Studies (13,021)
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 4,291 (32.95) | 18.7374 |
| 1990's | 2,207 (16.95) | 18.2507 |
| 2000's | 2,326 (17.86) | 29.6817 |
| 2010's | 3,089 (23.72) | 24.3611 |
| 2020's | 1,108 (8.51) | 2.80 |
Study Types
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 1,096 (6.57%) | 5.53% |
| Reviews | 1,423 (8.53%) | 6.00% |
| Case Studies | 795 (4.77%) | 4.05% |
| Observational | 42 (0.25%) | 0.25% |
| Other | 13,326 (79.88%) | 84.16% |