Page last updated: 2024-08-05 15:14:17

radiosensitizing agent

A drug that makes increases the sensitivity of tumour cells to radiation therapy.

ChEBI ID: 132992

Members (17)

MemberDefinitionClass
buforminA member of the class of biguanides that is biguanide substituted by a butyl group at position 1. It is an antidiabetic drug with potential antitumor effect.buformin
buteinA chalcone that is (E)-chalcone bearing four additional hydroxy substituents at positions 2', 3, 4 and 4'.butein
dihydroouabainA cardenolide glycoside that is ouabain in which the double bond in the lactone ring has been reduced to a single bond. It is a cardiac glycoside and a derivative of ouabain which is used as a sodium pump antagonist and exhibits ionotropic effects.dihydroouabain
etanidazoleA monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2-nitro-1H-imidazol-1-yl)acetic acid with the amino group of ethanolamine. Used as a radiosensitising agent for hypoxic tumour cells.etanidazole
floxuridineA pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.floxuridine
fluorouracilA nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.5-fluorouracil
gemcitabineA 2'-deoxycytidine having geminal fluoro substituents in the 2'-position. An inhibitor of ribonucleotide reductase, gemcitabine is used in the treatment of various carcinomas, particularly non-small cell lung cancer, pancreatic cancer, bladder cancer and breast cancer.gemcitabine
gemcitabine hydrochlorideA 2'-deoxycytidine hydrochloriode having geminal fluoro substituents in the 2'-position. An inhibitor of ribonucleotide reductase, gemcitabine hydrochloride is used in the treatment of various carcinomas, including non-small cell lung cancer, pancreatic cancer, bladder cancer and breast cancer.gemcitabine hydrochloride
gsk 2126458A member of the class of quinolines that is quinoline which is substituted by pyridazin-4-yl and 5-[(2,4-difluorobenzene-1-sulfonyl)amino]-6-methoxypyridin-3-yl groups at positions 4 and 6, respectively. It is a highly potent inhibitor of PI3K and mTOR developed by GlaxoSmithKline and was previously in human phase 1 clinical trials for the treatment of idiopathic pulmonary fibrosis and solid tumors.omipalisib
l 778,123The hydrochloride salt of L-778,123. It is a dual inhibitor of FPTase and GGPTase-I (IC50 of 2nM and 98nm, respectively) and exhibits anti-cancer properties.L-778,123 hydrochloride
metronidazoleA member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.metronidazole
niraparibA 2-[4-(piperidin-3-yl)phenyl]-2H-indazole-7-carboxamide that has S-configuration. It is a potent inhibitor of PARP1 and PARP2 (IC50 of 3.8 and 2.1 nM, respectively) and approved as a first-line maintenance treatment for women with advanced ovarian cancer after responding to platinum-based chemotherapy.niraparib
saracatinibA member of the class of quinazolines that is quinazoline substituted by (5-chloro-2H-1,3-benzodioxol-4-yl)amino, (oxan-4-yl)oxy and 2-(4-methylpiperazin-1-yl)ethoxy groups at positions 4, 5 and 7, respectively. It is a dual inhibitor of the tyrosine kinases c-Src and Abl (IC50 = 2.7 and 30 nM, respectively). Saracatinib was originally developed by AstraZeneca for the treatment of cancer but in 2019 it was granted orphan drug designation by the US Food and Drug Administration for the treatment of idiopathic pulmonary fibrosis (IPF), a type of lung disease that results in scarring (fibrosis) of the lungs.saracatinib
sm 164A potent cell-permeable and bivalent Smac mimetic which binds to XIAP, cIAP-1 and cIAP-2 proteins (Ki = 0.56 nM, 0.31 nM and 1.1 nM, respectively). It induces apoptosis and tumor regression in cancer xenograft models.SM-164
statticA member of the class of 1-benzothiophenes that is 1-benzothiophene-1,1-dioxide substituted at position 6 by a nitro group. Used as a radiosensitising agent for esophageal squamous cell carcinoma.stattic
undecylprodigiosinA member of the class of tripyrroles that is 1H-pyrrole substituted by (4'-methoxy-1H,5'H-[2,2'-bipyrrol]-5'-ylidene)methyl and undecyl groups at positions 2 and 5, respectively. It is a pigment produced by Stveptomyces coelicolor.undecylprodigiosin
wortmanninwortmannin

Research

Studies (73,934)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-199014,219 (19.23)18.7374
1990's11,629 (15.73)18.2507
2000's19,585 (26.49)29.6817
2010's22,076 (29.86)24.3611
2020's6,425 (8.69)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials15,462 (19.05%)5.53%
Reviews6,849 (8.44%)6.00%
Case Studies8,427 (10.38%)4.05%
Observational297 (0.37%)0.25%
Other50,125 (61.76%)84.16%

Protein Targets (523)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
67.9K proteinVaccinia virusPotency5.509227
acetylcholinesteraseHomo sapiens (human)Potency20.774311
activating transcription factor 6Homo sapiens (human)Potency0.213111
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency27.748113
Alpha-synucleinHomo sapiens (human)Potency12.804012
Amyloid-beta precursor proteinHomo sapiens (human)Potency12.080612
AR proteinHomo sapiens (human)Potency16.011199
arylsulfatase AHomo sapiens (human)Potency13.457312
ATAD5 protein, partialHomo sapiens (human)Potency4.90151011
Ataxin-2Homo sapiens (human)Potency13.442325
ATP-dependent phosphofructokinaseTrypanosoma brucei brucei TREU927Potency6.633812
ATPase family AAA domain-containing protein 5Homo sapiens (human)Potency7.819326
atrial natriuretic peptide receptor 1 precursorHomo sapiens (human)Potency10.691011
atrial natriuretic peptide receptor 2 precursorHomo sapiens (human)Potency5.847911
Cellular tumor antigen p53Homo sapiens (human)Potency7.0566313
Chain A, ATP-DEPENDENT DNA HELICASE Q1Homo sapiens (human)Potency35.481311
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency10.720514
chromobox protein homolog 1Homo sapiens (human)Potency72.594323
cytochrome P450 2C19 precursorHomo sapiens (human)Potency5.011911
cytochrome P450 2D6Homo sapiens (human)Potency29.294912
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency25.283212
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency10.590911
D(1A) dopamine receptorSus scrofa (pig)Potency1.849311
DNA dC->dU-editing enzyme APOBEC-3G isoform 1Homo sapiens (human)Potency17.782811
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency89.125111
DNA polymerase kappa isoform 1Homo sapiens (human)Potency21.192311
endonuclease IVEscherichia coliPotency8.912511
estrogen nuclear receptor alphaHomo sapiens (human)Potency17.1638921
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency11.398123
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency14.7226920
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency12.157815
EWS/FLI fusion proteinHomo sapiens (human)Potency11.5304421
farnesoid X nuclear receptorHomo sapiens (human)Potency13.268634
flap endonuclease 1Homo sapiens (human)Potency0.150011
Fumarate hydrataseHomo sapiens (human)Potency10.339215
gemininHomo sapiens (human)Potency5.0458210
GLI family zinc finger 3Homo sapiens (human)Potency4.257522
glp-1 receptor, partialHomo sapiens (human)Potency11.220211
GLS proteinHomo sapiens (human)Potency3.548111
glucocerebrosidaseHomo sapiens (human)Potency10.000011
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency5.570523
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency12.995412
GTP-binding nuclear protein Ran isoform 1Homo sapiens (human)Potency28.638412
Guanine nucleotide-binding protein GHomo sapiens (human)Potency11.220211
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)Homo sapiens (human)Potency24.404212
hemoglobin subunit betaHomo sapiens (human)Potency23.110333
histone acetyltransferase KAT2A isoform 1Homo sapiens (human)Potency14.342512
Histone H2A.xCricetulus griseus (Chinese hamster)Potency34.188227
huntingtin isoform 2Homo sapiens (human)Potency1.995311
hypoxia-inducible factor 1 alpha subunitHomo sapiens (human)Potency11.381911
IDH1Homo sapiens (human)Potency4.400714
importin subunit beta-1 isoform 1Homo sapiens (human)Potency28.638412
Inositol monophosphatase 1Rattus norvegicus (Norway rat)Potency28.183811
Interferon betaHomo sapiens (human)Potency10.914519
interleukin 8Homo sapiens (human)Potency66.824211
lamin isoform A-delta10Homo sapiens (human)Potency2.5695210
LuciferasePhotinus pyralis (common eastern firefly)Potency41.450211
Microtubule-associated protein tauHomo sapiens (human)Potency14.955923
mitogen-activated protein kinase 1Homo sapiens (human)Potency12.380712
muscleblind-like protein 1 isoform 1Homo sapiens (human)Potency87.680213
nonstructural protein 1Influenza A virus (A/WSN/1933(H1N1))Potency2.081212
NPC intracellular cholesterol transporter 1 precursorHomo sapiens (human)Potency47.409012
Nrf2Homo sapiens (human)Potency12.648322
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency17.589038
nuclear factor erythroid 2-related factor 2 isoform 2Homo sapiens (human)Potency4.059014
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency10.291822
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency6.5032312
parathyroid hormone/parathyroid hormone-related peptide receptor precursorHomo sapiens (human)Potency56.234111
ParkinHomo sapiens (human)Potency23.109311
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1Homo sapiens (human)Potency67.455511
peripheral myelin protein 22Rattus norvegicus (Norway rat)Potency5.027124
peripheral myelin protein 22 isoform 1Homo sapiens (human)Potency4.775511
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency28.856622
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency19.940711
phosphopantetheinyl transferaseBacillus subtilisPotency33.552012
plasminogen precursorMus musculus (house mouse)Potency0.014111
polyproteinZika virusPotency10.339215
PPM1D proteinHomo sapiens (human)Potency10.914516
pregnane X nuclear receptorHomo sapiens (human)Potency27.207126
pregnane X receptorRattus norvegicus (Norway rat)Potency56.234111
progesterone receptorHomo sapiens (human)Potency17.495622
RAR-related orphan receptor gammaMus musculus (house mouse)Potency1.636226
ras-related protein Rab-9AHomo sapiens (human)Potency29.730212
regulator of G-protein signaling 4Homo sapiens (human)Potency19.487612
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency1.922734
retinoid X nuclear receptor alphaHomo sapiens (human)Potency18.140624
serine/threonine-protein kinase mTOR isoform 1Homo sapiens (human)Potency6.985334
Smad3Homo sapiens (human)Potency12.062712
snurportin-1Homo sapiens (human)Potency28.638412
Spike glycoproteinSevere acute respiratory syndrome-related coronavirusPotency1.361124
survival motor neuron protein isoform dHomo sapiens (human)Potency8.423226
TAR DNA-binding protein 43Homo sapiens (human)Potency4.471612
TDP1 proteinHomo sapiens (human)Potency11.7682220
thioredoxin glutathione reductaseSchistosoma mansoniPotency35.481311
thioredoxin reductaseRattus norvegicus (Norway rat)Potency1.296634
ThrombopoietinHomo sapiens (human)Potency0.012622
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency1.8899210
thyroid hormone receptor beta isoform aHomo sapiens (human)Potency22.122024
thyroid stimulating hormone receptorHomo sapiens (human)Potency8.321624
transcriptional regulator ERG isoform 3Homo sapiens (human)Potency15.649812
tyrosine-protein kinase YesHomo sapiens (human)Potency11.502023
urokinase plasminogen activator surface receptor precursorMus musculus (house mouse)Potency0.014111
urokinase-type plasminogen activator precursorMus musculus (house mouse)Potency0.014111
USP1 protein, partialHomo sapiens (human)Potency50.118711
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency16.077411
vitamin D3 receptor isoform VDRAHomo sapiens (human)Potency34.1621510
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency12.995412
VprHuman immunodeficiency virus 1Potency13.891412
WRNHomo sapiens (human)Potency14.125411

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
17-beta-hydroxysteroid dehydrogenase type 2Homo sapiens (human)IC507.300011
3-phosphoinositide-dependent protein kinase 1Homo sapiens (human)IC5010.000011
5-hydroxytryptamine receptor 2ARattus norvegicus (Norway rat)IC500.002111
5-hydroxytryptamine receptor 2ARattus norvegicus (Norway rat)Ki0.004011
Alpha-2A adrenergic receptorRattus norvegicus (Norway rat)IC500.001211
Alpha-2B adrenergic receptorRattus norvegicus (Norway rat)IC500.001211
Alpha-2C adrenergic receptorRattus norvegicus (Norway rat)IC500.001211
Angiotensin-converting enzymeOryctolagus cuniculus (rabbit)IC50243,576.910033
AromataseHomo sapiens (human)IC500.630011
ATP-binding cassette sub-family C member 3Homo sapiens (human)IC50133.000014
Aurora kinase BHomo sapiens (human)IC5010.000011
Baculoviral IAP repeat-containing protein 2Homo sapiens (human)IC500.004044
Baculoviral IAP repeat-containing protein 2Homo sapiens (human)Ki0.001033
Baculoviral IAP repeat-containing protein 3Homo sapiens (human)IC500.008522
Baculoviral IAP repeat-containing protein 3Homo sapiens (human)Ki0.002022
Beta-secretase 1Homo sapiens (human)IC502.370011
Bile salt export pumpHomo sapiens (human)IC50223.028637
cAMP-dependent protein kinase catalytic subunit alphaHomo sapiens (human)IC5010.000011
cAMP-dependent protein kinase catalytic subunit betaHomo sapiens (human)IC5010.000011
cAMP-dependent protein kinase catalytic subunit gammaHomo sapiens (human)IC5010.000011
Canalicular multispecific organic anion transporter 1Homo sapiens (human)IC50111.275014
Chain A, DEOXYNUCLEOSIDE KINASEDrosophila melanogaster (fruit fly)IC500.760011
Chain A, Proto-oncogene tyrosine-protein kinase SrcHomo sapiens (human)IC500.002711
Chain A, Uracil PhosphoribosyltransferaseToxoplasma gondiiKi25.000011
Cyclin-dependent kinase 2Homo sapiens (human)IC5010.000011
Cytochrome P450 1A2Homo sapiens (human)IC500.001212
Cytochrome P450 3A4Homo sapiens (human)IC500.001623
D(2) dopamine receptorRattus norvegicus (Norway rat)IC500.002111
D(2) dopamine receptorRattus norvegicus (Norway rat)Ki0.004011
DNA-dependent protein kinase catalytic subunitHomo sapiens (human)Ki0.120022
Dual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)IC5014.000011
Dual specificity mitogen-activated protein kinase kinase 2Homo sapiens (human)IC5014.000011
E3 ubiquitin-protein ligase XIAPHomo sapiens (human)IC500.060566
E3 ubiquitin-protein ligase XIAPHomo sapiens (human)Ki0.023544
Enoyl-[acyl-carrier-protein] reductase [NADH] FabIEscherichia coli K-12IC5030.000011
Enoyl-acyl-carrier protein reductase Plasmodium falciparum (malaria parasite P. falciparum)IC5012.500011
Enoyl-acyl-carrier protein reductase Plasmodium falciparum (malaria parasite P. falciparum)Ki2.828033
Epidermal growth factor receptorHomo sapiens (human)IC504.595177
Equilibrative nucleoside transporter 1Homo sapiens (human)IC500.190011
Fibroblast growth factor receptor 1Homo sapiens (human)IC5010.000011
Glycogen synthase kinase-3 betaHomo sapiens (human)IC5010.000011
Hypoxia-inducible factor 1-alphaHomo sapiens (human)IC500.043011
Integrase Human immunodeficiency virus 1IC5019.976322
Kruppel-like factor 5Homo sapiens (human)IC503.854011
Lanosterol 14-alpha demethylaseHomo sapiens (human)IC50200.000011
Mast/stem cell growth factor receptor KitHomo sapiens (human)IC500.200033
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinaseHomo sapiens (human)IC505.209022
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinaseHomo sapiens (human)Ki2.619922
Metabotropic glutamate receptor 1Rattus norvegicus (Norway rat)IC500.008522
Mitogen-activated protein kinase 10Homo sapiens (human)IC5010.000011
Mitogen-activated protein kinase 8Homo sapiens (human)IC5010.000011
Mitogen-activated protein kinase 9Homo sapiens (human)IC5010.000011
Mu-type opioid receptorCavia porcellus (domestic guinea pig)IC5016.000011
Multidrug resistance-associated protein 4Homo sapiens (human)IC50115.550014
Muscarinic acetylcholine receptor M1Rattus norvegicus (Norway rat)IC503.854011
Myosin light chain kinase, smooth muscleGallus gallus (chicken)IC500.260011
Myosin light chain kinase, smooth muscleHomo sapiens (human)IC502.356733
Nuclear factor NF-kappa-B p100 subunit Homo sapiens (human)IC5038.000011
Nuclear factor NF-kappa-B p105 subunitHomo sapiens (human)IC5038.000011
Phosphatidylinositol 3-kinase regulatory subunit alphaHomo sapiens (human)IC5014,700.1894710
Phosphatidylinositol 3-kinase regulatory subunit alphaHomo sapiens (human)Ki0.000233
Phosphatidylinositol 4-kinase alphaHomo sapiens (human)IC500.280011
Phosphatidylinositol 4-kinase betaHomo sapiens (human)IC500.440011
Phosphatidylinositol 4-kinase type 2-alphaHomo sapiens (human)IC5030.000011
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformHomo sapiens (human)IC505,444.79142427
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformHomo sapiens (human)Ki0.040033
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoformHomo sapiens (human)IC5012,250.0251912
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoformHomo sapiens (human)Ki0.000322
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformHomo sapiens (human)IC5012,250.0238912
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformHomo sapiens (human)Ki0.000022
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Homo sapiens (human)IC509,803.69311215
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Homo sapiens (human)Ki0.000322
Phosphoinositide 3-kinase regulatory subunit 5Homo sapiens (human)IC500.019011
Platelet-derived growth factor receptor alphaHomo sapiens (human)IC5010.000011
Platelet-derived growth factor receptor betaHomo sapiens (human)IC505.000011
Poly [ADP-ribose] polymerase 1Homo sapiens (human)IC500.02781517
Poly [ADP-ribose] polymerase 1Homo sapiens (human)Ki0.003211
Poly [ADP-ribose] polymerase 2Homo sapiens (human)IC500.230678
Poly [ADP-ribose] polymerase 2Homo sapiens (human)Ki0.004011
Poly [ADP-ribose] polymerase tankyrase-1Homo sapiens (human)IC5011.317334
Poly [ADP-ribose] polymerase tankyrase-2Homo sapiens (human)IC505.129312
Polyunsaturated fatty acid 5-lipoxygenaseRattus norvegicus (Norway rat)IC500.004611
Protein mono-ADP-ribosyltransferase PARP10Homo sapiens (human)IC502.615324
Protein mono-ADP-ribosyltransferase PARP12Homo sapiens (human)IC500.436712
Protein mono-ADP-ribosyltransferase PARP14Homo sapiens (human)IC509.518912
Protein mono-ADP-ribosyltransferase PARP15Homo sapiens (human)IC5029.020212
Protein mono-ADP-ribosyltransferase PARP3Homo sapiens (human)IC500.379745
Protein mono-ADP-ribosyltransferase PARP4Homo sapiens (human)IC500.407623
Proto-oncogene tyrosine-protein kinase SrcHomo sapiens (human)IC5010.06751315
Rapamycin-insensitive companion of mTORHomo sapiens (human)IC500.000211
Serine/threonine-protein kinase mTORHomo sapiens (human)IC500.004999
Serine/threonine-protein kinase pim-1Homo sapiens (human)IC5010.000011
Serine/threonine-protein kinase PLK1Homo sapiens (human)IC500.443333
Serine/threonine-protein kinase PLK1Homo sapiens (human)Ki6.825014
Serine/threonine-protein kinase PLK2Homo sapiens (human)Ki6.825014
Serine/threonine-protein kinase PLK3Homo sapiens (human)IC500.105733
Serine/threonine-protein kinase PLK3Homo sapiens (human)Ki6.825014
Serine/threonine-protein kinase PLK4Homo sapiens (human)Ki6.825014
Signal transducer and activator of transcription 3Homo sapiens (human)IC505.100033
Sodium-dependent dopamine transporterRattus norvegicus (Norway rat)IC500.002111
Sodium-dependent dopamine transporterRattus norvegicus (Norway rat)Ki0.004011
Sodium/nucleoside cotransporter 2Homo sapiens (human)IC501,000.000011
Solute carrier family 15 member 1Homo sapiens (human)IC5012,210.000011
Target of rapamycin complex 2 subunit MAPKAP1Homo sapiens (human)IC500.000211
Target of rapamycin complex subunit LST8Homo sapiens (human)IC500.000211
Thioredoxin glutathione reductase Schistosoma mansoniIC502.010011
Thioredoxin reductase Entamoeba histolyticaKi3.300011
Thymidylate synthaseMus musculus (house mouse)IC505.04671420
Transcription factor p65Homo sapiens (human)IC5038.000011
Tyrosine-protein kinase ABL1Homo sapiens (human)IC500.030033
Tyrosine-protein kinase CSKHomo sapiens (human)IC500.840033
Tyrosine-protein kinase LckHomo sapiens (human)IC500.004033
Tyrosine-protein kinase YesHomo sapiens (human)IC500.003855
Vascular endothelial growth factor receptor 1 Homo sapiens (human)IC50100.000011
Vascular endothelial growth factor receptor 2Homo sapiens (human)IC5015.700734
Vascular endothelial growth factor receptor 3Homo sapiens (human)IC5010.000011
Voltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)IC50177.900011
Voltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)IC50177.900011
Voltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)IC50177.900011
Voltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)IC50177.900011
Xanthine dehydrogenase/oxidaseBos taurus (cattle)IC501.300011

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
26S proteasome regulatory subunit 6BHomo sapiens (human)Kd30.000012
5'-AMP-activated protein kinase catalytic subunit alpha-1Homo sapiens (human)Kd30.000012
5'-AMP-activated protein kinase subunit gamma-1Homo sapiens (human)Kd30.000012
5'-AMP-activated protein kinase subunit gamma-2Homo sapiens (human)Kd30.000012
AarF domain-containing protein kinase 1Homo sapiens (human)Kd30.000012
Actin-related protein 2Homo sapiens (human)Kd30.000012
Actin-related protein 3Homo sapiens (human)Kd30.000012
Activated CDC42 kinase 1Homo sapiens (human)Kd17.325012
Activin receptor type-1Homo sapiens (human)Kd15.002012
Activin receptor type-1BHomo sapiens (human)Kd15.071012
Activin receptor type-2BHomo sapiens (human)Kd16.939012
Acyl-CoA dehydrogenase family member 10Homo sapiens (human)Kd30.000011
Acyl-CoA dehydrogenase family member 11Homo sapiens (human)Kd30.000012
Adenine phosphoribosyltransferaseHomo sapiens (human)Kd30.000011
Adenosine kinaseHomo sapiens (human)Kd30.000012
Adenylate kinase 2, mitochondrialHomo sapiens (human)Kd30.000013
ADP/ATP translocase 2Homo sapiens (human)Kd30.000012
ADP/ATP translocase 3Homo sapiens (human)Kd30.000012
ALK tyrosine kinase receptorHomo sapiens (human)Kd30.000011
Angiotensin-converting enzyme 2 Homo sapiens (human)EC503.020013
AP2-associated protein kinase 1Homo sapiens (human)Kd30.000013
ATP-dependent 6-phosphofructokinase, platelet typeHomo sapiens (human)Kd30.000012
ATP-dependent RNA helicase DDX1Homo sapiens (human)Kd30.000012
ATP-dependent RNA helicase DDX3XHomo sapiens (human)Kd30.000012
ATP-dependent RNA helicase DDX42Homo sapiens (human)Kd30.000011
ATP-dependent RNA helicase DHX30Homo sapiens (human)Kd30.000012
Atypical kinase COQ8A, mitochondrialHomo sapiens (human)Kd20.091713
Aurora kinase AHomo sapiens (human)Kd30.000012
Aurora kinase BHomo sapiens (human)Kd30.000012
Beta-adrenergic receptor kinase 1Homo sapiens (human)Kd30.000012
BMP-2-inducible protein kinaseHomo sapiens (human)Kd30.000013
Bone morphogenetic protein receptor type-1AHomo sapiens (human)Kd15.030012
Bone morphogenetic protein receptor type-1BHomo sapiens (human)Kd15.014512
Bone morphogenetic protein receptor type-2Homo sapiens (human)Kd30.000012
Breakpoint cluster region proteinHomo sapiens (human)Kd15.008012
Calcium/calmodulin-dependent protein kinase kinase 2Homo sapiens (human)Kd30.000013
Calcium/calmodulin-dependent protein kinase type II subunit deltaHomo sapiens (human)Kd30.000012
Calcium/calmodulin-dependent protein kinase type II subunit gammaHomo sapiens (human)Kd30.000012
Calcium/calmodulin-dependent protein kinase type IVHomo sapiens (human)Kd30.000012
cAMP-dependent protein kinase catalytic subunit alphaHomo sapiens (human)Kd30.000012
cAMP-dependent protein kinase catalytic subunit betaHomo sapiens (human)Kd30.000012
cAMP-dependent protein kinase catalytic subunit gammaHomo sapiens (human)Kd30.000012
cAMP-dependent protein kinase type II-alpha regulatory subunitHomo sapiens (human)Kd30.000012
Casein kinase I isoform alphaHomo sapiens (human)Kd30.000013
Casein kinase I isoform deltaHomo sapiens (human)Kd30.000012
Casein kinase I isoform epsilonHomo sapiens (human)Kd30.000012
Casein kinase I isoform gamma-1Homo sapiens (human)Kd30.000012
Casein kinase I isoform gamma-2Homo sapiens (human)Kd30.000011
Casein kinase I isoform gamma-3Homo sapiens (human)Kd30.000012
Casein kinase II subunit alpha'Homo sapiens (human)Kd30.000012
Cell division cycle 7-related protein kinaseHomo sapiens (human)Kd30.000011
cGMP-dependent protein kinase 1 Homo sapiens (human)Kd30.000013
Chromodomain-helicase-DNA-binding protein 4Homo sapiens (human)Kd30.000012
Citron Rho-interacting kinaseHomo sapiens (human)Kd30.000013
Cyclin-dependent kinase 1Homo sapiens (human)Kd30.000012
Cyclin-dependent kinase 10Homo sapiens (human)Kd30.000011
Cyclin-dependent kinase 12Homo sapiens (human)Kd30.000012
Cyclin-dependent kinase 13Homo sapiens (human)Kd30.000012
Cyclin-dependent kinase 16Homo sapiens (human)Kd30.000012
Cyclin-dependent kinase 17Homo sapiens (human)Kd30.000012
Cyclin-dependent kinase 2Homo sapiens (human)Kd53.333323
Cyclin-dependent kinase 3Homo sapiens (human)Kd30.000012
Cyclin-dependent kinase 4Homo sapiens (human)Kd30.000012
Cyclin-dependent kinase 6Homo sapiens (human)Kd30.000012
Cyclin-dependent kinase 7Homo sapiens (human)Kd30.000012
Cyclin-dependent kinase 9Homo sapiens (human)Kd30.000012
Cyclin-dependent-like kinase 5 Homo sapiens (human)Kd30.000012
Cyclin-G-associated kinaseHomo sapiens (human)Kd15.054012
Cytochrome c1, heme protein, mitochondrialHomo sapiens (human)Kd30.000012
Cytochrome P450 1A2 Rattus norvegicus (Norway rat)EC500.004011
dCTP pyrophosphatase 1Homo sapiens (human)Kd30.000012
Delta(24)-sterol reductaseHomo sapiens (human)Kd30.000012
Deoxycytidine kinaseHomo sapiens (human)Kd30.000013
Discoidin domain-containing receptor 2Homo sapiens (human)Kd36.140012
DNA replication licensing factor MCM4Homo sapiens (human)Kd30.000013
DNA topoisomerase 2-alphaHomo sapiens (human)Kd30.000012
DNA topoisomerase 2-betaHomo sapiens (human)Kd30.000012
DnaJ homolog subfamily A member 1Homo sapiens (human)Kd30.000012
Dual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)Kd30.000012
Dual specificity mitogen-activated protein kinase kinase 2Homo sapiens (human)Kd30.000012
Dual specificity mitogen-activated protein kinase kinase 3Homo sapiens (human)Kd30.000012
Dual specificity mitogen-activated protein kinase kinase 4Homo sapiens (human)Kd30.000011
Dual specificity mitogen-activated protein kinase kinase 5Homo sapiens (human)Kd30.000012
Dual specificity mitogen-activated protein kinase kinase 6Homo sapiens (human)Kd30.000012
Dual specificity protein kinase CLK1Homo sapiens (human)Kd30.000012
Dual specificity protein kinase CLK2Homo sapiens (human)Kd30.000012
Dual specificity protein kinase CLK3Homo sapiens (human)Kd30.000011
Dual specificity protein kinase CLK4Homo sapiens (human)Kd30.000012
Dual specificity protein kinase TTKHomo sapiens (human)Kd30.000012
Dual specificity testis-specific protein kinase 1Homo sapiens (human)Kd30.000012
Dual specificity tyrosine-phosphorylation-regulated kinase 1AHomo sapiens (human)Kd30.000013
Dynamin-like 120 kDa protein, mitochondrialHomo sapiens (human)Kd30.000013
E3 ubiquitin-protein ligase XIAPHomo sapiens (human)EC500.257522
EKC/KEOPS complex subunit TP53RKHomo sapiens (human)Kd30.000012
Electron transfer flavoprotein subunit betaHomo sapiens (human)Kd30.000011
Elongation factor Tu, mitochondrialHomo sapiens (human)Kd30.000012
endoribonuclease toxin MazFEscherichia coli str. K-12 substr. MG1655EC5099.000022
Ephrin type-A receptor 1Homo sapiens (human)Kd0.010011
Ephrin type-A receptor 2Homo sapiens (human)Kd10.355723
Ephrin type-A receptor 4Homo sapiens (human)Kd15.458512
Ephrin type-A receptor 5Homo sapiens (human)Kd16.190512
Ephrin type-A receptor 7Homo sapiens (human)Kd30.000012
Ephrin type-B receptor 2Homo sapiens (human)Kd19.707512
Ephrin type-B receptor 3Homo sapiens (human)Kd30.000012
Ephrin type-B receptor 4Homo sapiens (human)Kd16.939012
Ephrin type-B receptor 6Homo sapiens (human)Kd16.801012
Epidermal growth factor receptorHomo sapiens (human)Kd30.000012
Epithelial discoidin domain-containing receptor 1Homo sapiens (human)Kd17.200512
Eukaryotic translation initiation factor 2-alpha kinase 1Homo sapiens (human)Kd30.000012
Eukaryotic translation initiation factor 5BHomo sapiens (human)Kd30.000011
Exosome RNA helicase MTR4Homo sapiens (human)Kd30.000012
Ferrochelatase, mitochondrialHomo sapiens (human)Kd30.000012
Fibroblast growth factor receptor 1Homo sapiens (human)Kd30.000012
Focal adhesion kinase 1Homo sapiens (human)Kd30.000012
G protein-coupled receptor kinase 6Homo sapiens (human)Kd30.000012
General transcription and DNA repair factor IIH helicase subunit XPDHomo sapiens (human)Kd30.000012
Glycine--tRNA ligaseHomo sapiens (human)Kd30.000012
Glycogen phosphorylase, brain formHomo sapiens (human)Kd30.000012
Glycogen phosphorylase, liver formHomo sapiens (human)Kd30.000012
Glycogen synthase kinase-3 alphaHomo sapiens (human)Kd30.000013
Glycogen synthase kinase-3 betaHomo sapiens (human)Kd30.000012
GTP-binding nuclear protein RanHomo sapiens (human)Kd30.000013
Guanine nucleotide-binding protein G(i) subunit alpha-2Homo sapiens (human)Kd30.000011
Heme oxygenase 2Homo sapiens (human)Kd30.000012
Hepatocyte growth factor receptorHomo sapiens (human)Kd30.000011
High affinity nerve growth factor receptorHomo sapiens (human)Kd30.000012
Inhibitor of nuclear factor kappa-B kinase subunit epsilonHomo sapiens (human)Kd30.000013
Inosine-5'-monophosphate dehydrogenase 2Homo sapiens (human)Kd30.000012
Insulin receptorHomo sapiens (human)Kd30.000012
Insulin-like growth factor 1 receptorHomo sapiens (human)Kd30.000013
Integrin-linked protein kinaseHomo sapiens (human)Kd30.000012
Interleukin-1 receptor-associated kinase 1Homo sapiens (human)Kd30.000012
Interleukin-1 receptor-associated kinase 3Homo sapiens (human)Kd16.516512
Interleukin-1 receptor-associated kinase 4Homo sapiens (human)Kd30.000013
Isoleucine--tRNA ligase, mitochondrialHomo sapiens (human)Kd30.000011
LIM domain kinase 1Homo sapiens (human)Kd30.000012
LIM domain kinase 2Homo sapiens (human)Kd30.000012
Long-chain-fatty-acid--CoA ligase 5Homo sapiens (human)Kd30.000012
Macrophage-stimulating protein receptorHomo sapiens (human)Kd30.000012
MAP kinase-activated protein kinase 2Homo sapiens (human)Kd30.000012
MAP kinase-activated protein kinase 3Homo sapiens (human)Kd30.000011
MAP kinase-activated protein kinase 5Homo sapiens (human)Kd30.000012
MAP/microtubule affinity-regulating kinase 3Homo sapiens (human)Kd30.000012
MAP/microtubule affinity-regulating kinase 4Homo sapiens (human)Kd30.000013
Mast/stem cell growth factor receptor KitHomo sapiens (human)Kd30.000011
Maternal embryonic leucine zipper kinaseHomo sapiens (human)Kd30.000012
Membrane-associated progesterone receptor component 1Homo sapiens (human)Kd30.000011
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinaseHomo sapiens (human)Kd20.939023
MidasinHomo sapiens (human)Kd30.000012
Misshapen-like kinase 1Homo sapiens (human)Kd30.000012
Mitogen-activated protein kinase 1Homo sapiens (human)Kd30.000012
Mitogen-activated protein kinase 10Homo sapiens (human)Kd30.000012
Mitogen-activated protein kinase 11Homo sapiens (human)Kd30.000012
Mitogen-activated protein kinase 14Homo sapiens (human)Kd30.000012
Mitogen-activated protein kinase 15Homo sapiens (human)Kd30.000014
Mitogen-activated protein kinase 3 Homo sapiens (human)Kd30.000012
Mitogen-activated protein kinase 7Homo sapiens (human)Kd30.000012
Mitogen-activated protein kinase 8Homo sapiens (human)Kd30.000012
Mitogen-activated protein kinase 9Homo sapiens (human)Kd30.000012
Mitogen-activated protein kinase kinase kinase 1Homo sapiens (human)Kd30.000012
Mitogen-activated protein kinase kinase kinase 11Homo sapiens (human)Kd30.000012
Mitogen-activated protein kinase kinase kinase 2Homo sapiens (human)Kd30.000013
Mitogen-activated protein kinase kinase kinase 20Homo sapiens (human)Kd16.492512
Mitogen-activated protein kinase kinase kinase 3Homo sapiens (human)Kd30.000012
Mitogen-activated protein kinase kinase kinase 4Homo sapiens (human)Kd30.000012
Mitogen-activated protein kinase kinase kinase 5Homo sapiens (human)Kd30.000012
Mitogen-activated protein kinase kinase kinase 6Homo sapiens (human)Kd30.000013
Mitogen-activated protein kinase kinase kinase kinase 1Homo sapiens (human)Kd30.000013
Mitogen-activated protein kinase kinase kinase kinase 2Homo sapiens (human)Kd30.000012
Mitogen-activated protein kinase kinase kinase kinase 3Homo sapiens (human)Kd30.000012
Mitogen-activated protein kinase kinase kinase kinase 4Homo sapiens (human)Kd15.560512
Mitogen-activated protein kinase kinase kinase kinase 5Homo sapiens (human)Kd28.544012
Mitotic checkpoint serine/threonine-protein kinase BUB1Homo sapiens (human)Kd30.000011
Multifunctional protein ADE2Homo sapiens (human)Kd30.000012
Myosin light chain kinase 3Homo sapiens (human)Kd30.000013
Myosin light chain kinase, smooth muscleHomo sapiens (human)Kd30.000012
Myosin-10Homo sapiens (human)Kd30.000012
Myosin-14Homo sapiens (human)Kd30.000012
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13Homo sapiens (human)Kd30.000012
Non-receptor tyrosine-protein kinase TNK1Homo sapiens (human)Kd30.000012
Non-receptor tyrosine-protein kinase TYK2Homo sapiens (human)Kd30.000012
NUAK family SNF1-like kinase 2Homo sapiens (human)Kd30.000012
Nucleolar GTP-binding protein 1Homo sapiens (human)Kd30.000011
Nucleoside diphosphate kinase BHomo sapiens (human)Kd30.000012
Obg-like ATPase 1Homo sapiens (human)Kd30.000011
PAS domain-containing serine/threonine-protein kinaseHomo sapiens (human)Kd30.000012
Peroxisomal acyl-coenzyme A oxidase 1Homo sapiens (human)Kd30.000011
Peroxisomal acyl-coenzyme A oxidase 3Homo sapiens (human)Kd30.000012
Phenylalanine--tRNA ligase beta subunitHomo sapiens (human)Kd30.000012
Phosphatidylethanolamine-binding protein 1Homo sapiens (human)Kd30.000011
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformHomo sapiens (human)Kd0.005411
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoformHomo sapiens (human)Kd0.007611
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformHomo sapiens (human)Kd0.005511
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Homo sapiens (human)Kd0.015011
Phosphatidylinositol 5-phosphate 4-kinase type-2 alphaHomo sapiens (human)Kd30.000012
Phosphatidylinositol 5-phosphate 4-kinase type-2 gammaHomo sapiens (human)Kd15.686012
Phosphorylase b kinase gamma catalytic chain, liver/testis isoformHomo sapiens (human)Kd30.000012
Platelet-derived growth factor receptor betaHomo sapiens (human)Kd15.315512
Poly [ADP-ribose] polymerase 1Homo sapiens (human)EC507.802044
Poly [ADP-ribose] polymerase 1Homo sapiens (human)Kd0.001011
Poly [ADP-ribose] polymerase 2Homo sapiens (human)EC500.004022
Poly [ADP-ribose] polymerase 2Homo sapiens (human)Kd0.078011
Poly [ADP-ribose] polymerase tankyrase-2Homo sapiens (human)Kd10.000011
Probable ATP-dependent RNA helicase DDX6Homo sapiens (human)Kd30.000012
Procathepsin LHomo sapiens (human)EC503.020013
Protein kinase C alpha typeHomo sapiens (human)Kd30.000012
Protein kinase C beta typeHomo sapiens (human)Kd30.000013
Protein kinase C delta typeHomo sapiens (human)Kd30.000012
Protein kinase C iota typeHomo sapiens (human)Kd30.000012
Protein kinase C theta typeHomo sapiens (human)Kd30.000012
Protein kinase C zeta typeHomo sapiens (human)Kd30.000013
Protein mono-ADP-ribosyltransferase PARP10Homo sapiens (human)Kd5.000011
Protein mono-ADP-ribosyltransferase PARP11Homo sapiens (human)Kd10.000011
Protein mono-ADP-ribosyltransferase PARP12Homo sapiens (human)Kd10.000011
Protein mono-ADP-ribosyltransferase PARP14Homo sapiens (human)Kd10.000011
Protein mono-ADP-ribosyltransferase PARP16Homo sapiens (human)Kd10.000011
Protein mono-ADP-ribosyltransferase PARP3Homo sapiens (human)EC500.004022
Protein mono-ADP-ribosyltransferase PARP4Homo sapiens (human)Kd0.272011
Protein-tyrosine kinase 2-betaHomo sapiens (human)Kd30.000012
Protein-tyrosine kinase 6Homo sapiens (human)Kd15.283012
Proto-oncogene tyrosine-protein kinase receptor RetHomo sapiens (human)Kd15.089012
Proto-oncogene tyrosine-protein kinase SrcHomo sapiens (human)Kd15.066012
Putative heat shock protein HSP 90-beta 2Homo sapiens (human)Kd30.000013
Putative nucleoside diphosphate kinaseHomo sapiens (human)Kd30.000011
Pyridoxal kinaseHomo sapiens (human)Kd30.000012
Rab-like protein 3Homo sapiens (human)Kd30.000012
RAC-alpha serine/threonine-protein kinaseHomo sapiens (human)Kd30.000012
RAC-beta serine/threonine-protein kinaseHomo sapiens (human)Kd30.000012
RAC-gamma serine/threonine-protein kinaseHomo sapiens (human)Kd30.000012
Ras-related protein Rab-10Homo sapiens (human)Kd30.000012
Ras-related protein Rab-27AHomo sapiens (human)Kd30.000012
Ras-related protein Rab-6AHomo sapiens (human)Kd30.000012
Receptor-interacting serine/threonine-protein kinase 2Homo sapiens (human)Kd15.001012
Receptor-interacting serine/threonine-protein kinase 3Homo sapiens (human)Kd15.884012
Receptor-type tyrosine-protein kinase FLT3Homo sapiens (human)Kd15.070012
Replicase polyprotein 1aSevere acute respiratory syndrome-related coronavirusEC503.020013
Replicase polyprotein 1abBetacoronavirus England 1EC503.020013
Replicase polyprotein 1abHuman coronavirus 229EEC503.020013
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2EC503.020013
Replicase polyprotein 1abSevere acute respiratory syndrome-related coronavirusEC503.020013
Rho-associated protein kinase 1Homo sapiens (human)Kd30.000012
Rho-associated protein kinase 2Homo sapiens (human)Kd30.000012
Ribosomal protein S6 kinase alpha-1Homo sapiens (human)Kd30.000012
Ribosomal protein S6 kinase alpha-3Homo sapiens (human)Kd30.000012
Ribosomal protein S6 kinase alpha-4Homo sapiens (human)Kd30.000012
Ribosomal protein S6 kinase alpha-5Homo sapiens (human)Kd30.000012
Ribosomal protein S6 kinase alpha-6Homo sapiens (human)Kd30.000013
Ribosomal protein S6 kinase beta-1Homo sapiens (human)Kd30.000012
Ribosyldihydronicotinamide dehydrogenase [quinone]Homo sapiens (human)Kd30.000013
RNA cytidine acetyltransferaseHomo sapiens (human)Kd30.000012
S-adenosylmethionine synthase isoform type-2Homo sapiens (human)Kd30.000012
Septin-9Homo sapiens (human)Kd30.000012
Serine/threonine-protein kinase 10Homo sapiens (human)Kd20.840512
Serine/threonine-protein kinase 16Homo sapiens (human)Kd30.000012
Serine/threonine-protein kinase 24Homo sapiens (human)Kd30.000012
Serine/threonine-protein kinase 26Homo sapiens (human)Kd30.000012
Serine/threonine-protein kinase 3Homo sapiens (human)Kd30.000012
Serine/threonine-protein kinase 38Homo sapiens (human)Kd30.000011
Serine/threonine-protein kinase 38-likeHomo sapiens (human)Kd30.000011
Serine/threonine-protein kinase 4Homo sapiens (human)Kd30.000012
Serine/threonine-protein kinase A-RafHomo sapiens (human)Kd30.000012
Serine/threonine-protein kinase ATRHomo sapiens (human)Kd30.000012
Serine/threonine-protein kinase B-rafHomo sapiens (human)Kd30.000012
Serine/threonine-protein kinase Chk1Homo sapiens (human)Kd30.000012
Serine/threonine-protein kinase D2Homo sapiens (human)Kd30.000012
Serine/threonine-protein kinase D3Homo sapiens (human)Kd30.000012
Serine/threonine-protein kinase ICKHomo sapiens (human)Kd30.000012
Serine/threonine-protein kinase LATS1Homo sapiens (human)Kd30.000012
Serine/threonine-protein kinase MARK2Homo sapiens (human)Kd30.000012
Serine/threonine-protein kinase MRCK alphaHomo sapiens (human)Kd30.000012
Serine/threonine-protein kinase MRCK betaHomo sapiens (human)Kd30.000012
Serine/threonine-protein kinase MRCK gammaHomo sapiens (human)Kd30.000012
Serine/threonine-protein kinase mTORHomo sapiens (human)Kd9.200011
Serine/threonine-protein kinase N1Homo sapiens (human)Kd30.000012
Serine/threonine-protein kinase N2Homo sapiens (human)Kd30.000012
Serine/threonine-protein kinase N3Homo sapiens (human)Kd30.000011
Serine/threonine-protein kinase Nek1Homo sapiens (human)Kd30.000012
Serine/threonine-protein kinase Nek2Homo sapiens (human)Kd30.000013
Serine/threonine-protein kinase Nek3Homo sapiens (human)Kd30.000012
Serine/threonine-protein kinase Nek7Homo sapiens (human)Kd30.000012
Serine/threonine-protein kinase Nek9Homo sapiens (human)Kd30.000012
Serine/threonine-protein kinase NLKHomo sapiens (human)Kd30.000012
Serine/threonine-protein kinase PAK 2Homo sapiens (human)Kd30.000011
Serine/threonine-protein kinase PAK 4Homo sapiens (human)Kd30.000013
Serine/threonine-protein kinase PAK 6Homo sapiens (human)Kd30.000011
Serine/threonine-protein kinase pim-1Homo sapiens (human)EC505.005022
Serine/threonine-protein kinase pim-1Homo sapiens (human)Kd30.000012
Serine/threonine-protein kinase pim-2Homo sapiens (human)EC505.005022
Serine/threonine-protein kinase pim-2Homo sapiens (human)Kd30.000011
Serine/threonine-protein kinase pim-3Homo sapiens (human)EC505.005022
Serine/threonine-protein kinase PLK1Homo sapiens (human)Kd30.000012
Serine/threonine-protein kinase PLK4Homo sapiens (human)Kd30.000012
Serine/threonine-protein kinase SIK2Homo sapiens (human)Kd15.703512
Serine/threonine-protein kinase SIK3Homo sapiens (human)Kd17.425512
Serine/threonine-protein kinase STK11Homo sapiens (human)Kd30.000013
Serine/threonine-protein kinase TAO1Homo sapiens (human)Kd30.000012
Serine/threonine-protein kinase TAO2Homo sapiens (human)Kd30.000012
Serine/threonine-protein kinase TAO3Homo sapiens (human)Kd30.000012
Serine/threonine-protein kinase TBK1Homo sapiens (human)Kd30.000012
Serine/threonine-protein kinase ULK1Homo sapiens (human)Kd30.000012
Serine/threonine-protein kinase ULK3Homo sapiens (human)Kd30.000012
Serine/threonine-protein kinase/endoribonuclease IRE1Homo sapiens (human)Kd30.000012
Serine/threonine-protein kinase/endoribonuclease IRE2Homo sapiens (human)Kd30.000012
Signal recognition particle receptor subunit alphaHomo sapiens (human)Kd30.000012
Signal transducer and activator of transcription 3Homo sapiens (human)Kd1.528011
Spike glycoproteinBetacoronavirus England 1EC503.020013
Spike glycoproteinSevere acute respiratory syndrome-related coronavirusEC503.020013
STE20-like serine/threonine-protein kinase Homo sapiens (human)Kd30.856512
STE20-related kinase adapter protein alphaHomo sapiens (human)Kd30.000012
streptokinase A precursorStreptococcus pyogenes M1 GASEC500.689011
Structural maintenance of chromosomes protein 1AHomo sapiens (human)Kd30.000012
Structural maintenance of chromosomes protein 2Homo sapiens (human)Kd30.000012
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrialHomo sapiens (human)Kd30.000011
TGF-beta receptor type-1Homo sapiens (human)Kd15.098512
TGF-beta receptor type-2Homo sapiens (human)Kd30.000012
Thyroid hormone receptor-associated protein 3Homo sapiens (human)Kd30.000011
TRAF2 and NCK-interacting protein kinaseHomo sapiens (human)Kd15.687512
Transmembrane protease serine 2Homo sapiens (human)EC503.020013
Tyrosine--tRNA ligase, cytoplasmicHomo sapiens (human)Kd30.000012
Tyrosine-protein kinase ABL1Homo sapiens (human)Kd15.026512
Tyrosine-protein kinase ABL2Homo sapiens (human)Kd15.045512
Tyrosine-protein kinase BTKHomo sapiens (human)Kd20.076512
Tyrosine-protein kinase CSKHomo sapiens (human)Kd34.776512
Tyrosine-protein kinase FerHomo sapiens (human)Kd30.000012
Tyrosine-protein kinase Fes/FpsHomo sapiens (human)Kd30.000012
Tyrosine-protein kinase FgrHomo sapiens (human)Kd0.956011
Tyrosine-protein kinase FRKHomo sapiens (human)Kd16.165012
Tyrosine-protein kinase FynHomo sapiens (human)Kd15.049012
Tyrosine-protein kinase HCKHomo sapiens (human)Kd15.050012
Tyrosine-protein kinase JAK1Homo sapiens (human)Kd30.000012
Tyrosine-protein kinase JAK2Homo sapiens (human)Kd30.000011
Tyrosine-protein kinase LckHomo sapiens (human)Kd15.004512
Tyrosine-protein kinase LynHomo sapiens (human)Kd15.056512
Tyrosine-protein kinase SYKHomo sapiens (human)Kd30.000012
Tyrosine-protein kinase TecHomo sapiens (human)Kd30.000012
Tyrosine-protein kinase YesHomo sapiens (human)Kd15.047512
U5 small nuclear ribonucleoprotein 200 kDa helicaseHomo sapiens (human)Kd30.000012
UMP-CMP kinase Homo sapiens (human)Kd30.000011
Uncharacterized aarF domain-containing protein kinase 5Homo sapiens (human)Kd30.000011
Uncharacterized protein FLJ45252Homo sapiens (human)Kd30.000012
Very long-chain specific acyl-CoA dehydrogenase, mitochondrialHomo sapiens (human)Kd30.000012
Wee1-like protein kinaseHomo sapiens (human)Kd30.000012

Other Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
AAA family ATPase Staphylococcus aureusKm192.000011
Cytidine deaminaseHomo sapiens (human)Km600.666733
Cytochrome P450 1A2 Rattus norvegicus (Norway rat)EC900.045011
Deoxycytidine kinaseHomo sapiens (human)Km1.775022
FlavodoxinHelicobacter pylori 26695MIC67.300033
heat shock protein 90, putativePlasmodium falciparum 3D7AC500.215011
heat shock protein HSP 90-alpha isoform 2Homo sapiens (human)AC500.363011
HSP40, subfamily A [Plasmodium falciparum 3D7]Plasmodium falciparum 3D7AbsAC1000_uM0.562011
interferon gamma precursorHomo sapiens (human)AC500.346011
PAX8Homo sapiens (human)AC505.380011
Poly [ADP-ribose] polymerase 1Homo sapiens (human)EC900.045011
Poly [ADP-ribose] polymerase 1Homo sapiens (human)IC900.049333
Poly [ADP-ribose] polymerase 2Homo sapiens (human)EC900.045011
Poly [ADP-ribose] polymerase 2Homo sapiens (human)IC900.049333
Protein mono-ADP-ribosyltransferase PARP3Homo sapiens (human)EC900.045011
Protein mono-ADP-ribosyltransferase PARP3Homo sapiens (human)IC900.049333
Skn7pSaccharomyces cerevisiae (brewer's yeast)AbsAC40_uM9.320011
Solute carrier family 22 member 1Rattus norvegicus (Norway rat)Km48.800011
Solute carrier family 22 member 8Mus musculus (house mouse)Km0.053911
Thymidine kinaseVaccinia virus WRKm113.000011
Thymidine phosphorylaseHomo sapiens (human)Km631.000011