Page last updated: 2024-08-05 15:26:25
androgen
A sex hormone that stimulates or controls the development and maintenance of masculine characteristics in vertebrates by binding to androgen receptors.
ChEBI ID: 50113
Members (38)
| Member | Definition | Class |
|---|---|---|
| 11 beta-hydroxyandrosterone | 3alpha,11beta-Dihydroxy-5alpha-androstane-17-one | |
| 11-hydroxyandrostenedione | 11-Hydroxyandrostenedione | |
| 11-ketoetiocholanolone | 11-Ketoetiocholanolone | |
| 11-ketotestosterone | A 3-oxo Delta(4)-steroid that is testosterone carrying an additional oxo substituent at position 11. | 11-oxotestosterone |
| 15-hydroxytestosterone | An androstanoid that is testosterone substituted by a alpha-hydroxy group at position 15. A natural product found in Daphnia magna exposed to the biocide tributyltin. | 15alpha-hydroxytestosterone |
| 16-hydroxytestosterone | A C19-steroid that is testosterone in which the hydrogen at the 16alpha position has been replaced by a hydroxy group. | 16alpha-hydroxytestosterone |
| 3beta-hydroxy-17-(1h-benzimidazole-1-yl)androsta-5,16-diene | Galeterone | |
| 4-androstene-3,17-diol | 4-Androstenediol | |
| 5-androstene-3,16,17-triol | 5-Androstenetriol | |
| adrenosterone | A 3-oxo Delta(4)-steroid that is androst-4-ene carrying three oxo-substituents at positions 3, 11 and 17. | adrenosterone |
| androstan-3-ol | 5alpha-Androstan-3beta-ol | |
| androstenediol | A 3beta-hydroxy-Delta(5)-steroid that is 3beta-hydroxyandrost-5-ene carrying an additional hydroxy group at position 17beta. | androst-5-ene-3beta,17beta-diol |
| androstenedione | A 3-oxo Delta(4)-steroid that is androst-4-ene substituted by oxo groups at positions 3 and 17. It is a steroid hormone synthesized in the adrenal glands and gonads. | androst-4-ene-3,17-dione |
| androsterone | An androstanoid that is 5alpha-androstane having a hydroxy substituent at the 3alpha-position and an oxo group at the 17-position. It is a metabolite of dehydroepiandrosterone . | androsterone |
| bolasterone | Bolasterone | |
| calusterone | calusterone | |
| clostebol | clostebol | |
| d-4-chloro-17 beta-hydroxy-3-oxo-17 alpha-methylandrosta-1,4-diene | 4-Chloromethandienone | |
| dehydroepiandrosterone | An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands. | dehydroepiandrosterone |
| dihydrotestosterone | A 17beta-hydroxy steroid that is testosterone in which the 4,5 double bond has been reduced to a single bond with alpha-configuration at position 5. | 17beta-hydroxy-5alpha-androstan-3-one |
| dimethisterone | Dimethisterone | |
| epiandrosterone | A 3beta-hydroxy steroid that is (5alpha)-androstane substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. | epiandrosterone |
| epietiocholanolone | A 3beta-hydroxy steroid that is 5beta-androstane substituted by a hydroxy group at position 3beta and an oxo group at position 17. It is a metabolite of testosterone. | epietiocholanolone |
| medroxyprogesterone acetate | An acetate ester resulting from the formal condensation of the 17alpha-hydroxy group of medroxyprogesterone with the carboxy group of acetic acid. A widely used progestin in menopausal hormone therapy and in progestogen-only birth control. | medroxyprogesterone acetate |
| methandriol | Methandriol | |
| methenolone | methenolone | |
| methyltestosterone | A 17beta-hydroxy steroid that is testosterone bearing a methyl group at the 17alpha position. | methyltestosterone |
| metribolone | A synthetic non-aromatisable androgen and anabolic steroid. It binds strongly to the androgen receptor and has therefore also been used as an affinity label for this receptor in the prostate and in prostatic tumors. | 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one |
| mibolerone | An androgen that is nalandrone carrying two methyl substituents at positions 7alpha and 17. | mibolerone |
| nandrolone phenpropionate | nandrolone phenpropionate | |
| oxandrolone | oxandrolone | |
| pregna-4,17-diene-3,16-dione | E-Guggulsterone | |
| quinbolone | quinbolone | |
| stanozolol | An organic heteropentacyclic compound resulting from the formal condensation of the 3-keto-aldehyde moiety of oxymetholone with hydrazine. Like oxymetholone, it is a synthetic anabolic steroid. It has both anabolic and androgenic properties, and has been used to treat hereditary angioedema and various vascular disorders. It has also been widely abused by professional athletes. | stanozolol |
| stenbolone | Stenbolone | |
| testosterone | 17-hydroxy-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one | |
| testosterone enanthate | testosterone enanthate | |
| tipredane | Tipredane |
Research
Studies (33,528)
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 13,639 (40.68) | 18.7374 |
| 1990's | 6,307 (18.81) | 18.2507 |
| 2000's | 6,749 (20.13) | 29.6817 |
| 2010's | 5,408 (16.13) | 24.3611 |
| 2020's | 1,425 (4.25) | 2.80 |
Study Types
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 2,952 (7.36%) | 5.53% |
| Reviews | 2,338 (5.83%) | 6.00% |
| Case Studies | 1,367 (3.41%) | 4.05% |
| Observational | 66 (0.16%) | 0.25% |
| Other | 33,367 (83.23%) | 84.16% |
Protein Targets (194)
Potency Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| acetylcholinesterase | Homo sapiens (human) | Potency | 53.3259 | 3 | 7 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 27.4411 | 1 | 2 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 25.7672 | 1 | 4 |
| Alpha-synuclein | Homo sapiens (human) | Potency | 4.3666 | 1 | 4 |
| AR protein | Homo sapiens (human) | Potency | 8.3881 | 12 | 140 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 8.6349 | 1 | 1 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 29.0810 | 1 | 1 |
| Ataxin-2 | Homo sapiens (human) | Potency | 21.6899 | 1 | 1 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 21.6899 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 251.1890 | 2 | 2 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 68.3804 | 1 | 1 |
| caspase-3 | Cricetulus griseus (Chinese hamster) | Potency | 26.8346 | 1 | 1 |
| caspase-3 | Homo sapiens (human) | Potency | 68.3804 | 1 | 1 |
| Caspase-7 | Cricetulus griseus (Chinese hamster) | Potency | 26.8346 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 30.2832 | 2 | 9 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 25.2171 | 2 | 3 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 39.8107 | 1 | 1 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 26.7449 | 2 | 4 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 17.7828 | 1 | 1 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 26.7449 | 2 | 4 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 91.7731 | 1 | 5 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 14.0033 | 1 | 5 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 22.4637 | 1 | 4 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 10.8993 | 2 | 6 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 11.6356 | 1 | 7 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 7.5909 | 1 | 14 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 4.4668 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 32.3042 | 1 | 3 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 13.0417 | 12 | 122 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 11.9596 | 3 | 33 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 35.3432 | 8 | 90 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 6.2560 | 1 | 2 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 29.7251 | 4 | 18 |
| G | Vesicular stomatitis virus | Potency | 14.0033 | 1 | 5 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 10.8993 | 1 | 3 |
| GALC protein | Homo sapiens (human) | Potency | 0.7079 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 10.8993 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 10.8993 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 10.8993 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 10.8993 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 10.8993 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 10.8993 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 10.8993 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 10.8993 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 10.8993 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 10.8993 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 10.8993 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 10.8993 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 10.8993 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 10.8993 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 10.8993 | 1 | 3 |
| geminin | Homo sapiens (human) | Potency | 16.4621 | 2 | 11 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 16.6687 | 3 | 38 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 19.7636 | 2 | 3 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 20.5324 | 1 | 3 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 10.5747 | 5 | 36 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 34.8674 | 1 | 7 |
| GTP-binding nuclear protein Ran isoform 1 | Homo sapiens (human) | Potency | 6.5131 | 1 | 1 |
| Guanine nucleotide-binding protein G | Homo sapiens (human) | Potency | 14.4617 | 2 | 3 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 22.8351 | 2 | 8 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 24.3616 | 1 | 2 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 61.7929 | 2 | 12 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 14.0033 | 1 | 5 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 29.4449 | 2 | 3 |
| IDH1 | Homo sapiens (human) | Potency | 17.1332 | 1 | 2 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 6.5131 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 14.0033 | 1 | 10 |
| Interferon beta | Homo sapiens (human) | Potency | 13.8785 | 2 | 6 |
| interleukin 8 | Homo sapiens (human) | Potency | 70.9011 | 1 | 4 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 22.7406 | 1 | 2 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 31.6228 | 1 | 1 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 35.7168 | 1 | 2 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 0.4956 | 1 | 2 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 1.3815 | 1 | 2 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 18.2149 | 1 | 3 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 34.5587 | 4 | 31 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 0.2214 | 1 | 2 |
| nuclear factor NF-kappa-B p105 subunit isoform 1 | Homo sapiens (human) | Potency | 40.8708 | 1 | 2 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 35.9521 | 1 | 6 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 29.0775 | 1 | 6 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 19.1498 | 1 | 2 |
| nuclear receptor subfamily 1, group I, member 2 | Rattus norvegicus (Norway rat) | Potency | 1.2589 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 19.9257 | 3 | 8 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| Parkin | Homo sapiens (human) | Potency | 40.8708 | 1 | 2 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 21.1892 | 1 | 2 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 84.9214 | 1 | 1 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 30.2725 | 5 | 15 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 31.3275 | 5 | 30 |
| PINK1 | Homo sapiens (human) | Potency | 40.8708 | 1 | 2 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 12.5893 | 1 | 1 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 29.1274 | 1 | 4 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 29.5168 | 3 | 23 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 16.8951 | 1 | 4 |
| progesterone receptor | Homo sapiens (human) | Potency | 7.1207 | 3 | 35 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 26.4540 | 2 | 34 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 0.0060 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 36.2589 | 3 | 30 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 24.7696 | 4 | 36 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 21.8657 | 2 | 14 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 21.8657 | 2 | 14 |
| Smad3 | Homo sapiens (human) | Potency | 6.3096 | 1 | 1 |
| snurportin-1 | Homo sapiens (human) | Potency | 6.5131 | 1 | 1 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 21.8113 | 1 | 3 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 7.3866 | 1 | 4 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 26.4217 | 1 | 6 |
| TDP1 protein | Homo sapiens (human) | Potency | 21.7278 | 2 | 26 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 70.7946 | 1 | 1 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 29.1858 | 2 | 28 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 22.7798 | 1 | 2 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 12.1892 | 3 | 4 |
| thyrotropin-releasing hormone receptor | Homo sapiens (human) | Potency | 17.6081 | 2 | 2 |
| transcriptional regulator ERG isoform 3 | Homo sapiens (human) | Potency | 12.4464 | 1 | 3 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 12.5893 | 1 | 1 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 12.5893 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 23.7849 | 2 | 15 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 27.0068 | 5 | 23 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 34.8674 | 1 | 7 |
Inhibition Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | IC50 | 1.1970 | 1 | 1 |
| Adenosine receptor A3 | Homo sapiens (human) | IC50 | 8.3250 | 1 | 1 |
| Adenosine receptor A3 | Homo sapiens (human) | Ki | 4.7050 | 1 | 1 |
| Aldo-keto reductase family 1 member C1 | Homo sapiens (human) | IC50 | 1.8000 | 1 | 1 |
| Aldo-keto reductase family 1 member C2 | Homo sapiens (human) | IC50 | 4.0405 | 2 | 2 |
| Aldo-keto reductase family 1 member C3 | Homo sapiens (human) | IC50 | 1.4059 | 2 | 2 |
| ALK tyrosine kinase receptor | Homo sapiens (human) | Ki | 0.0002 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 8.3250 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 4.7050 | 1 | 1 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 8.3250 | 1 | 1 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 4.7050 | 1 | 1 |
| Alpha-synuclein | Homo sapiens (human) | IC50 | 85.9000 | 1 | 1 |
| Androgen receptor | Homo sapiens (human) | IC50 | 3.6629 | 35 | 36 |
| Androgen receptor | Mus musculus (house mouse) | IC50 | 0.0010 | 1 | 1 |
| Androgen receptor | Rattus norvegicus (Norway rat) | IC50 | 2.6893 | 12 | 26 |
| Androgen receptor | Homo sapiens (human) | Ki | 0.0128 | 27 | 27 |
| Androgen receptor | Rattus norvegicus (Norway rat) | Ki | 0.0026 | 7 | 11 |
| Aromatase | Homo sapiens (human) | IC50 | 0.2800 | 2 | 2 |
| Aromatase | Homo sapiens (human) | Ki | 0.4562 | 4 | 4 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Beta-glucuronidase | Escherichia coli K-12 | IC50 | 253.9500 | 1 | 2 |
| Beta-glucuronidase | Homo sapiens (human) | IC50 | 77.9000 | 1 | 1 |
| Bile acid receptor | Homo sapiens (human) | IC50 | 27.4778 | 9 | 9 |
| Bile acid receptor | Mus musculus (house mouse) | IC50 | 66.5000 | 2 | 6 |
| Bile acid receptor | Homo sapiens (human) | Ki | 5.0000 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 12.8500 | 2 | 2 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Cannabinoid receptor 2 | Mus musculus (house mouse) | Ki | 0.0002 | 1 | 1 |
| Chain A, retinol dehydratase | Spodoptera frugiperda (fall armyworm) | Ki | 0.1100 | 1 | 1 |
| Cholinesterase | Homo sapiens (human) | IC50 | 1.5500 | 1 | 1 |
| Corticosteroid-binding globulin | Homo sapiens (human) | Ki | 5.0790 | 1 | 5 |
| Cytochrome P450 2C19 | Homo sapiens (human) | IC50 | 0.0480 | 1 | 1 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 1.1276 | 1 | 1 |
| Cytochrome P450 2D6 | Homo sapiens (human) | IC50 | 9.2740 | 1 | 1 |
| Estrogen receptor | Homo sapiens (human) | IC50 | 9.9073 | 7 | 7 |
| Estrogen receptor | Homo sapiens (human) | Ki | 2.5160 | 2 | 2 |
| Estrogen receptor beta | Homo sapiens (human) | IC50 | 1.3736 | 5 | 5 |
| Estrogen receptor beta | Homo sapiens (human) | Ki | 5.0000 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | IC50 | 1.3670 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | IC50 | 1.3670 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | IC50 | 1.3670 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | IC50 | 1.3670 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | IC50 | 1.3670 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | IC50 | 0.7885 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | IC50 | 1.3670 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | IC50 | 1.3670 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | IC50 | 1.3670 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | IC50 | 0.7885 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | IC50 | 1.3670 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | IC50 | 1.3670 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | IC50 | 1.3670 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | IC50 | 0.7885 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | IC50 | 1.3670 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | IC50 | 1.3670 | 1 | 1 |
| Glucocorticoid receptor | Homo sapiens (human) | IC50 | 14.8803 | 6 | 7 |
| Glucocorticoid receptor | Rattus norvegicus (Norway rat) | IC50 | 13.3341 | 3 | 3 |
| Glucocorticoid receptor | Homo sapiens (human) | Ki | 0.1274 | 8 | 9 |
| Glucose-6-phosphate 1-dehydrogenase | Homo sapiens (human) | IC50 | 39.8229 | 4 | 7 |
| Glucose-6-phosphate 1-dehydrogenase | Homo sapiens (human) | Ki | 5.3750 | 2 | 4 |
| Glucose-6-phosphate 1-dehydrogenase | Trypanosoma brucei | Ki | 0.9375 | 2 | 4 |
| Glycine receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | IC50 | 0.9310 | 1 | 2 |
| Glycine receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Ki | 0.4233 | 1 | 2 |
| Glycine receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | IC50 | 0.9310 | 1 | 2 |
| Glycine receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Ki | 0.4233 | 1 | 2 |
| Glycine receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | IC50 | 0.9310 | 1 | 2 |
| Glycine receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Ki | 0.4233 | 1 | 2 |
| Glycine receptor subunit beta | Rattus norvegicus (Norway rat) | IC50 | 0.9310 | 1 | 2 |
| Glycine receptor subunit beta | Rattus norvegicus (Norway rat) | Ki | 0.4233 | 1 | 2 |
| Histamine H2 receptor | Homo sapiens (human) | IC50 | 27.9200 | 1 | 1 |
| Histamine H2 receptor | Homo sapiens (human) | Ki | 27.4530 | 1 | 1 |
| Mineralocorticoid receptor | Rattus norvegicus (Norway rat) | IC50 | 2.1000 | 2 | 2 |
| Mineralocorticoid receptor | Homo sapiens (human) | IC50 | 0.8785 | 6 | 6 |
| Mineralocorticoid receptor | Homo sapiens (human) | Ki | 0.0198 | 2 | 2 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 22.5000 | 1 | 1 |
| Muscarinic acetylcholine receptor | Cavia porcellus (domestic guinea pig) | Ki | 0.0002 | 1 | 1 |
| Nuclear receptor subfamily 1 group I member 2 | Homo sapiens (human) | IC50 | 50.0012 | 2 | 2 |
| Oxysterols receptor LXR-alpha | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Oxysterols receptor LXR-beta | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Peroxisome proliferator-activated receptor alpha | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| Peroxisome proliferator-activated receptor delta | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Peroxisome proliferator-activated receptor gamma | Homo sapiens (human) | IC50 | 27.0000 | 1 | 1 |
| Plasma kallikrein | Homo sapiens (human) | IC50 | 0.0031 | 1 | 1 |
| Progesterone receptor | Homo sapiens (human) | IC50 | 16.9332 | 7 | 7 |
| Progesterone receptor | Oryctolagus cuniculus (rabbit) | IC50 | 0.4400 | 2 | 2 |
| Progesterone receptor | Homo sapiens (human) | Ki | 0.0205 | 10 | 10 |
| Retinoic acid receptor alpha | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Retinoic acid receptor beta | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Retinoic acid receptor gamma | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Retinoic acid receptor RXR-alpha | Homo sapiens (human) | IC50 | 33.0000 | 1 | 1 |
| Sex hormone-binding globulin | Homo sapiens (human) | IC50 | 0.0038 | 1 | 1 |
| Sex hormone-binding globulin | Rattus norvegicus (Norway rat) | IC50 | 0.0134 | 2 | 2 |
| Solute carrier organic anion transporter family member 1A1 | Rattus norvegicus (Norway rat) | Ki | 10.6000 | 1 | 1 |
| Steroid 17-alpha-hydroxylase/17,20 lyase | Homo sapiens (human) | IC50 | 0.2530 | 6 | 6 |
| Steroid 21-hydroxylase | Homo sapiens (human) | IC50 | 0.1626 | 2 | 2 |
| Testosterone 17-beta-dehydrogenase 3 | Homo sapiens (human) | IC50 | 0.5693 | 6 | 6 |
| Thyroid hormone receptor alpha | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Thyroid hormone receptor beta | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Vitamin D3 receptor | Homo sapiens (human) | IC50 | 2.0000 | 1 | 1 |
Activation Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Androgen receptor | Homo sapiens (human) | EC50 | 0.0649 | 31 | 32 |
| Androgen receptor | Mus musculus (house mouse) | EC50 | 0.0054 | 3 | 3 |
| Androgen receptor | Rattus norvegicus (Norway rat) | EC50 | 0.0019 | 2 | 2 |
| Androgen receptor | Homo sapiens (human) | Kd | 0.0009 | 12 | 12 |
| Angiotensin-converting enzyme | Rattus norvegicus (Norway rat) | EC50 | 0.0060 | 2 | 7 |
| Bile acid receptor | Homo sapiens (human) | EC50 | 14.5514 | 7 | 7 |
| Bile acid receptor | Mus musculus (house mouse) | EC50 | 34.6000 | 2 | 3 |
| Chain A, androgen receptor | Homo sapiens (human) | Kd | 0.0005 | 1 | 4 |
| Chain A, Sex Hormone-Binding Globulin | Homo sapiens (human) | Kd | 0.0009 | 1 | 1 |
| Estrogen receptor | Homo sapiens (human) | EC50 | 25.2440 | 4 | 4 |
| Estrogen receptor beta | Homo sapiens (human) | EC50 | 0.3119 | 3 | 3 |
| G-protein coupled bile acid receptor 1 | Homo sapiens (human) | EC50 | 3.9720 | 1 | 5 |
| Glucocorticoid receptor | Homo sapiens (human) | EC50 | 25.0075 | 4 | 4 |
| heat shock protein 90 | Candida albicans | EC50 | 5.6500 | 1 | 1 |
| Mineralocorticoid receptor | Homo sapiens (human) | EC50 | 100.0000 | 1 | 1 |
| NPC1-like intracellular cholesterol transporter 1 | Homo sapiens (human) | EC50 | 10.0000 | 1 | 1 |
| Nuclear receptor subfamily 1 group I member 2 | Homo sapiens (human) | EC50 | 2.5000 | 1 | 1 |
| Oxysterols receptor LXR-alpha | Homo sapiens (human) | EC50 | 100.0000 | 1 | 1 |
| Oxysterols receptor LXR-beta | Homo sapiens (human) | EC50 | 3.6000 | 1 | 1 |
| Peroxisome proliferator-activated receptor alpha | Homo sapiens (human) | EC50 | 100.0000 | 1 | 1 |
| Peroxisome proliferator-activated receptor delta | Homo sapiens (human) | EC50 | 100.0000 | 1 | 1 |
| Peroxisome proliferator-activated receptor gamma | Homo sapiens (human) | EC50 | 100.0000 | 1 | 1 |
| Progesterone receptor | Homo sapiens (human) | EC50 | 1.1169 | 18 | 18 |
| Retinoic acid receptor alpha | Homo sapiens (human) | EC50 | 100.0000 | 1 | 1 |
| Retinoic acid receptor beta | Homo sapiens (human) | EC50 | 100.0000 | 1 | 1 |
| Retinoic acid receptor gamma | Homo sapiens (human) | EC50 | 100.0000 | 1 | 1 |
| Retinoic acid receptor RXR-alpha | Homo sapiens (human) | EC50 | 100.0000 | 1 | 1 |
| Sex hormone-binding globulin | Homo sapiens (human) | Kd | 0.0770 | 1 | 10 |
| Thyroid hormone receptor alpha | Homo sapiens (human) | EC50 | 100.0000 | 1 | 1 |
| Thyroid hormone receptor beta | Homo sapiens (human) | EC50 | 100.0000 | 1 | 1 |
| Vitamin D3 receptor | Homo sapiens (human) | EC50 | 100.0000 | 1 | 1 |
Other Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Androgen receptor | Homo sapiens (human) | Activity | 0.0080 | 2 | 2 |
| Androgen receptor | Homo sapiens (human) | DC50 | 10.4100 | 1 | 1 |
| Androgen receptor | Homo sapiens (human) | EC150 | 0.0005 | 1 | 1 |
| Aromatase | Homo sapiens (human) | Km | 0.0421 | 4 | 4 |
| Aromatase | Homo sapiens (human) | Ks | 0.1050 | 1 | 1 |
| Corticosteroid-binding globulin | Homo sapiens (human) | Log Ki | 5,000.0000 | 1 | 1 |
| Gastrin/cholecystokinin type B receptor | Rattus norvegicus (Norway rat) | Km | 0.0575 | 1 | 1 |
| Glucocorticoid receptor | Homo sapiens (human) | EC150 | 0.0005 | 1 | 1 |
| Neuropeptide FF receptor 2 | Rattus norvegicus (Norway rat) | Activity | 0.0080 | 1 | 1 |