A DNA polymerase inhibitor that interferes with the action of a RNA-directed RNA polymerase (EC 2.7.7.48).
ChEBI ID: 170010
| Member | Definition | Class |
|---|---|---|
| 3-deoxyguanosine | A 3'-deoxyribonucleoside having guanine as the nucleobase. | 3'-deoxyguanosine |
| baicalin | The glycosyloxyflavone which is the 7-O-glucuronide of baicalein. It is an active ingredient of Chinese herbal medicine Scutellaria baicalensis. | baicalin |
| favipiravir | A member of the class of pyrazines that is pyrazine substituted by aminocarbonyl, hydroxy and fluoro groups at positions 2, 3 and 6, respectively. It is an anti-viral agent that inhibits RNA-dependent RNA polymerase of several RNA viruses and is approved for the treatment of influenza in Japan. | favipiravir |
| ribavirin 5'-triphosphate | A 1-ribosyltriazole that is ribavirin in which the hydroxy group at the 5'-position is replaced by a triphosphate group. It is the active metabolite of the antiviral agent ribavirin. | ribavirin 5'-triphosphate |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 9 (0.45) | 18.7374 |
| 1990's | 61 (3.02) | 18.2507 |
| 2000's | 316 (15.64) | 29.6817 |
| 2010's | 907 (44.90) | 24.3611 |
| 2020's | 727 (35.99) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 62 (3.00%) | 5.53% |
| Reviews | 157 (7.60%) | 6.00% |
| Case Studies | 62 (3.00%) | 4.05% |
| Observational | 13 (0.63%) | 0.25% |
| Other | 1,773 (85.78%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 7 | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| Aurora kinase B | Homo sapiens (human) | IC50 | 12.1900 | 1 | 1 |
| Canalicular multispecific organic anion transporter 1 | Rattus norvegicus (Norway rat) | Ki | 7.9500 | 1 | 1 |
| Cyclin-dependent kinase 1 | Homo sapiens (human) | IC50 | 14.3600 | 1 | 1 |
| Dipeptidyl peptidase 4 | Homo sapiens (human) | IC50 | 225.0000 | 1 | 1 |
| G2/mitotic-specific cyclin-B1 | Homo sapiens (human) | IC50 | 14.3600 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Homo sapiens (human) | Ki | 77.6247 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Homo sapiens (human) | Ki | 77.6247 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Homo sapiens (human) | Ki | 77.6247 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Homo sapiens (human) | Ki | 77.6247 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Homo sapiens (human) | Ki | 77.6247 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Homo sapiens (human) | Ki | 77.6247 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Homo sapiens (human) | Ki | 77.6247 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Homo sapiens (human) | Ki | 77.6247 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Homo sapiens (human) | Ki | 77.6247 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | Homo sapiens (human) | Ki | 77.6247 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | Homo sapiens (human) | Ki | 77.6247 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Homo sapiens (human) | Ki | 77.6247 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Homo sapiens (human) | Ki | 77.6247 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Homo sapiens (human) | Ki | 77.6247 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | Homo sapiens (human) | Ki | 77.6247 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit theta | Homo sapiens (human) | Ki | 77.6247 | 1 | 1 |
| Genome polyprotein | IC50 | 180.0000 | 1 | 1 | |
| Lysine-specific histone demethylase 1A | Homo sapiens (human) | IC50 | 3.1900 | 3 | 3 |
| Prolyl endopeptidase | Homo sapiens (human) | IC50 | 12.1500 | 2 | 2 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | IC50 | 6.4104 | 4 | 5 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | IC50 | 6.4100 | 1 | 1 |
| RNA-directed RNA polymerase | IC50 | 0.6000 | 1 | 1 | |
| Serine/threonine-protein kinase PLK1 | Homo sapiens (human) | IC50 | 3.6100 | 1 | 1 |
| Trypsin-1 | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| Trypsin-2 | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| Trypsin-3 | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Chain A, NDP kinase | Dictyostelium discoideum | Kd | 24.0000 | 1 | 1 |
| Histamine H1 receptor | Cavia porcellus (domestic guinea pig) | EC50 | 50.0000 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | EC50 | 10.2700 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | Kd | 11.9500 | 2 | 2 |
| RNA-directed RNA polymerase | EC50 | 50.0000 | 1 | 1 |